References of "Joint Bone Spine"
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See detailDoes signalling pathways inhibition hold therapeutic promise for osteoarthritis?
Henrotin, Yves ULg

in Joint Bone Spine (2014), 81

Signalling pathways inhibition hold promise as therapeutic targets in osteoarthritis but safety concern may limit their use to the more sevre form of the disease.

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See detailDistinctive aspects of laboratory testing to evaluate mineral and bone metabolism in patients with chronic kidney disease
Souberbielle, Jean-Claude; Cheriet, Sarah; CAVALIER, Etienne ULg

in Joint Bone Spine (2012), 79(suppl 2), 99-103

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See detailCryotherapy in rheumatic diseases
Demoulin, Christophe ULg; Vanderthommen, Marc ULg

in Joint Bone Spine (2012), 79

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See detailIs volition the missing link in the management of low back pain?
Broonen, Jean-Paul ULg; Marty, Marc; Legout, Virgine et al

in Joint Bone Spine (2011), 78

Patients with nonspecific chronic low back pain are typically prescribed a regimen of regular physical exercises to improve pain and function, increase workability, and prevent pain recurrence. However ... [more ▼]

Patients with nonspecific chronic low back pain are typically prescribed a regimen of regular physical exercises to improve pain and function, increase workability, and prevent pain recurrence. However, adherence to home exercise programs is often partial at best. Patients often fail to translate their intention to exercise (motivation) into action (implementation). Volition is the mental activity by which intentions are implemented. In this review, we argue that volition may be crucial to the successful rehabilitation of patients with low back pain. Obstacles to the implementation of intentions are described, as well as factors that promote implementation, most notably the conscious formation of implementation intentions. [less ▲]

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See detailOsteochondral plate angiogenesis: A new treatment target in osteoarthritis.
Pesesse, Laurence ULg; Sanchez, Christelle ULg; Henrotin, Yves ULg

in Joint Bone Spine (2011), 78

Healthy adult joint cartilage contains neither blood vessels nor nerves. Osteoarthritic cartilage, in contrast, may be invaded by blood vessels from the subchondral bone. The mechanisms underlying ... [more ▼]

Healthy adult joint cartilage contains neither blood vessels nor nerves. Osteoarthritic cartilage, in contrast, may be invaded by blood vessels from the subchondral bone. The mechanisms underlying cartilage angiogenesis in osteoarthritis are unclear but may involve hypertrophic chondrocyte differentiation. Active research is under way to identify the factors involved in cartilage angiogenesis. Here, we discuss the pathophysiological mechanisms of osteoarthritic cartilage angiogenesis based on evidence from a systematic literature review of articles retrieved via PubMed and ISI Web of Knowledge. Our conclusions suggest new research perspectives and treatment options. [less ▲]

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See detailUpdate in cartilage bio-engineering.
Gabay, Odile; Sanchez, Christelle ULg; Taboas, Juan M

in Joint Bone Spine (2010), 77(4), 283-6

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See detailFibromyalgia and related conditions: Electromyogram profile during isometric muscle contraction
Maquet, Didier ULg; Croisier, Jean-Louis ULg; Dupont, Catherine ULg et al

in Joint Bone Spine (2010), 77

Objectives: To evaluate electromyogram (EMG) profiles in patients with three related conditions: fibromyalgia, chronic fatigue syndrome, and depression. Methods: We studied 44 healthy volunteers, 22 ... [more ▼]

Objectives: To evaluate electromyogram (EMG) profiles in patients with three related conditions: fibromyalgia, chronic fatigue syndrome, and depression. Methods: We studied 44 healthy volunteers, 22 patients with fibromyalgia, 11 patients with chronic fatigue syndrome, and 10 patients admitted for depression. The trapezius electromyogram was recorded during maximally sustained, bilateral, 90◦ abduction of the shoulders. EMG signal frequency and amplitude were measured throughout the test. Results: In the fibromyalgia group, isometric contraction duration was significantly shorter than in the other two patient groups (P < 0.001) and the EMG frequency and amplitude pattern indicated premature discontinuation of the muscle contraction. Findings in the chronic fatigue patients were similar to those in the healthy controls. The patients with depression had a distinctive EMG profile characterized by excessive initial motor-unit recruitment with a shift in the frequency spectrum. Conclusions: Fibromyalgia was associated with a specific EMG pattern indicating premature discontinuation of the muscle contraction. Therefore, maximal voluntary muscle contraction tests may be of limited value for assessing function in fibromyalgia patients. Chronic fatigue syndrome patients had similar EMG findings to those in the healthy controls. The EMG alterations in the patients with depression were consistent with manifestations of psychomotor retardation. [less ▲]

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See detailEffectiveness of a semi-intensive multidisciplinary outpatient rehabilitation program in chronic low back pain
Demoulin, Christophe ULg; Grosdent, Stéphanie ULg; Capron, Lucile et al

in Joint Bone Spine (2010), 77

Objectives: To evaluate the efficacy of a semi-intensive multidisciplinary outpatient program complying with the requirements of the Belgian National Institute for Health and Disability Insurance and ... [more ▼]

Objectives: To evaluate the efficacy of a semi-intensive multidisciplinary outpatient program complying with the requirements of the Belgian National Institute for Health and Disability Insurance and intended for patients with chronic low back pain. Methods: Weincluded 262 patients with nonspecific chronic low back pain, amongwhom136 (73women and 63 men) with a mean pain duration of 11.3 years completed the outpatient program (36 sessions each lasting 2 h). The program consisted of education about back-sparing techniques, interventions by an occupational therapist and psychologist, and physical reconditioning. Three sessions (sessions 1, 18, and 36) were used to evaluate pain intensity, functional impairment, kinesiophobia, cognitive knowledge, knowledge of appropriate spinal movement technique, and physical performance (trunk muscle strength and endurance, mobility of the pelvis and lumbar spine, and aerobic capacity). Results: All study variables were significantly improved at study completion compared to baseline: pain intensity was decreased by 44%, functional impairment by 40%, and kinesiophobia by 11% whereas knowledge was improved by 59%, back-sparing technique by 95%, trunk muscle strength by 40% on average, trunk extensor muscle endurance by 90%, mobility by 8%, and aerobic capacity by 18%. Conclusions: A semi-intensive multidisciplinary outpatient program was beneficial in patients with chronic low back pain. Careful patient selection and increased patient involvement in the program may help to improve adherence. [less ▲]

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See detailInformation for patients with low back pain: from research to clinical practice.
Marty, Marc; Henrotin, Yves ULg

in Joint Bone Spine (2009), 76(6), 621-2

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See detailOARSI recommendations on knee and hip osteoarthritis: use with discernment.
Chevalier, Xavier; Henrotin, Yves ULg

in Joint Bone Spine (2009), 76(5), 455-7

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See detailVitamin D inadequacy in French osteoporotic and osteopenic women.
De Cock, Caroline; Bruyère, Olivier ULg; Collette, Julien ULg et al

in Joint Bone Spine (2008), 75(5), 567-72

OBJECTIVE: Studies have shown that low serum vitamin D levels are associated with secondary hyperparathyroidism, which decreases bone strength and increases fracture risk, most notably after 50 years of ... [more ▼]

OBJECTIVE: Studies have shown that low serum vitamin D levels are associated with secondary hyperparathyroidism, which decreases bone strength and increases fracture risk, most notably after 50 years of age. The objective of this study was to evaluate the vitamin D status of postmenopausal women in France. METHODS: We conducted a cross-sectional observational study of 1292 menopausal women with osteoporosis or osteopenia. The age range was 52-94 years. Serum 25-OH-vitamin D was assayed in each patient. Based on data in the literature, we used four 25-OH-D cutoffs to define vitamin D deficiency: 30, 50, 75, and 80 nmol/L (<12, <20, <30, and <32 ng/ml). RESULTS: Mean serum 25-OH-D was 51.5+/-26.1 nmol/L (about 20.6+/-10.4 ng/ml). In the 343 (26.5%) patients taking supplemental vitamin D with or without supplemental calcium, the mean serum 25-OH-D level was significantly higher than in the other patients (65.0+/-26.0 ng/ml vs. 46.6+/-18.6 ng/ml; P<0.001). In the subgroup not taking vitamin D supplements, the prevalence of vitamin D deficiency was 27.3%, 54.1%, 89.9%, and 93.2% with the 30, 50, 75, and 80 nmol/L cutoffs, respectively. The mean 25-OH-D level varied across seasons (P<0.001), with the highest value being obtained in summer (53.4+/-18.7 nmol/L; about 21.3+/-7.5 ng/ml). CONCLUSION: Vitamin D deficiency is common among postmenopausal women with osteoporosis or osteopenia in France. [less ▲]

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See detailOsteoarthritis and obesity: Experimental models.
Gabay, Odile; Hall, David; Berenbaum, Francis et al

in Joint Bone Spine (2008), 75

Osteoarthritis (OA) is a multifactorial disease. Different risk factors have been identified such as aging and obesity and different models have been used to study the impact of obesity and overweight in ... [more ▼]

Osteoarthritis (OA) is a multifactorial disease. Different risk factors have been identified such as aging and obesity and different models have been used to study the impact of obesity and overweight in this pathology. The field the more studied is in vitro cartilage submitted to mechanical stresses. Four different stresses can be applied on this tissue: shear stress, loading, tensile stress (stretching) and hydrostatic pressure. The signal transduction to the chondrocyte and to the nucleus of the cell is a large field of investigation named mechano-transduction. The response of cartilage depends on quality of subchondral bone as well. So, more and more teams are studying the impact of mechanical stresses on bone, mainly by stretching osteoblasts or by submitting them to a fluid shear stress. Recently, a new model of bone compression has been set up, with osteoblasts in their own extracellular matrix. Finally the third field studied is the role of adipokines, mediators playing a key role in obesity, on the aetiology of OA. Adipokines like leptin, resistin, adiponectin and visfatin, seems to play a pro-inflammatory role in arthritis. Studying the role of obesity in OA could be more complex than expected. The link between OA and obesity may not simply be due to high mechanical stresses applied on the tissues, but soluble mediators may play an important role in the onset of OA in obese patients. [less ▲]

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See detailSpinal muscle evaluation in healthy individuals and low-back-pain patients: A literature review
Demoulin, Christophe ULg; Crielaard, Jean-Michel ULg; Vanderthommen, Marc ULg

in Joint Bone Spine (2007), 74

This article reviews available techniques for spinal muscle investigation, as well as data on spinal muscles in healthy individuals and in patients with low back pain. In patients with chronic low back ... [more ▼]

This article reviews available techniques for spinal muscle investigation, as well as data on spinal muscles in healthy individuals and in patients with low back pain. In patients with chronic low back pain, medical imaging studies show paraspinal muscle wasting with reductions in cross-sectional surface area and fiber density. In healthy individuals, the paraspinal muscles contain a high proportion of slow-twitch fibers (Type I), reflecting their role in maintaining posture. The proportion of Type I fibers is higher in females, leading to better adaptation to aerobic exertion compared to males. Abnormalities seen in paraspinal muscles from patients with chronic low back pain include marked Type II fiber atrophy, conversion of Type I to Type II fibers, and an increased number of nonspecific abnormalities. Limited data are available from magnetic resonance spectroscopy used to investigate muscle metabolism and from near infrared spectroscopy used to measure oxygen uptake by the paraspinal muscles. Surface electromyography in patients with chronic low back pain shows increased paraspinal muscle fatigability, often with abolition of the flexion-relaxation phenomenon. [less ▲]

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See detailSpinal muscle evaluation using the Sorensen test: a critical appraisal of the literature
Demoulin, Christophe ULg; Vanderthommen, Marc ULg; Duysens, Christophe ULg et al

in Joint Bone Spine (2006), 73

The first test for evaluating the isometric endurance of trunk extensor muscles was described by Hansen in 1964. In 1984, following a study by Biering-Sorensen, this test became known as the “Sorensen ... [more ▼]

The first test for evaluating the isometric endurance of trunk extensor muscles was described by Hansen in 1964. In 1984, following a study by Biering-Sorensen, this test became known as the “Sorensen test” and gained considerable popularity as a tool reported to predict low back pain within the next year in males. The test consists in measuring the amount of time a person can hold the unsupported upper body in a horizontal prone position with the lower body fixed to the examining table. This test has been used in many studies, either in its original version or as variants. Although its discriminative validity, reproducibility, and safety seem good, debate continues to surround its ability to predict low back pain; in addition, the gender-related difference in position-holding time remains unexplained and the influence of body weight unclear. A contribution of the hip extensor muscles to position holding has been established, but its magnitude remains unknown. The influence of personal factors such as motivation complicates the interpretation of the results. Despite these drawbacks, the Sorensen test has become the tool of reference for evaluating muscle performance in patients with low back pain, most notably before and after rehabilitation programs. [less ▲]

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See detailMuscle performance in patients with fibromyalgia
Maquet, Didier ULg; Croisier, Jean-Louis ULg; Renard, Cindy ULg et al

in Joint Bone Spine (2002), 69(3), 293-299

Objectives. To compare muscle performance in women with fibromyalgia and in healthy women. Patients and methods. Sixteen women with fibromyalgia syndrome (FMS) and 85 healthy women who were physically ... [more ▼]

Objectives. To compare muscle performance in women with fibromyalgia and in healthy women. Patients and methods. Sixteen women with fibromyalgia syndrome (FMS) and 85 healthy women who were physically inactive or engaged in recreational sports underwent measurements of four parameters: maximal concentric isokinetic muscle strength of the knee extensors and flexors in the dominant limb, isometric grip strength on a Colin dynamometer, muscle fatigue resistance during 30 maximal concentric isokinetic contractions of the dominant knee flexors and extensors at 180° angular velocity, and static endurance during posture maintenance. Results. All muscle variables were decreased in the FMS patients as compared to the controls.The decreases were more marked during aerobic than during anaerobic exercise.Mean decreases were 39% (P<0.001) for muscle strength, 40% (P<0.0001) for fatigue resistance, and 81% (P<0.0001) for static endurance. Pain during exercise as evaluated using a visual analog scale was more marked in the FMS patients. Conclusion. This study of the three pathways supplying energy to muscle confirms that muscle function is globally impaired in FMS patients.The results suggest that the impairment predominates on aerobic processes. [less ▲]

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