Comment écrire pour transmettre ? Modalités argumenatives chez Ferdinand de Saussure

in Genesis (2012), 35

This article aims to examine and highlight what appears to have been the typical approach whereby Saussure built his arguments. We focus on the genesis of a theme addressed by the linguist in the ... [more ▼]

This article aims to examine and highlight what appears to have been the typical approach whereby Saussure built his arguments. We focus on the genesis of a theme addressed by the linguist in the preparation of a report on a book published by J. Schmidt (1895), namely the many anomalies of the (generally assumed) “theory of sonorants”. Seeking the multiple reformulations of this idea throughout this dossier (relatively complete, which is rare in Saussure), we try to highlight some characteristics specifi c to the theoretical arguments in the humanities. [less ▲]

Modulating skeletal muscle mass by postnatal, muscle-specific inactivation of the myostatin gene

in Genesis (2003), 35(4), 227-238

By using a conditional gene targeting approach exploiting the cre-lox system, we show that postnatal inactivation of the myostatin gene in striated muscle is sufficient to cause a generalized muscular ... [more ▼]

By using a conditional gene targeting approach exploiting the cre-lox system, we show that postnatal inactivation of the myostatin gene in striated muscle is sufficient to cause a generalized muscular hypertrophy of the same magnitude as that observed for constitutive myostatin knockout mice. This formally demonstrates that striated muscle is the production site of functional myostatin and that this member of the TGFbeta family of growth and differentiation factors regulates muscle mass not only during early embryogenesis but throughout development. It indicates that myostatin antagonist could be used to treat muscle wasting and to promote muscle growth in man and animals. (C) 2003 Wiley-Liss, Inc. [less ▲]