References of "European Neuropsychopharmacology"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailConcomitant manipulation of NMDA- and AMPA-receptors to produce pro-cognitive drug effects
Vignisse, Julie ULg; Steinbusch, Harry W.M.; Grigoriev, Vladimir et al

in European Neuropsychopharmacology (2014), 24

Bifunctional drug therapy targeting distinct receptor signaling systems can generate increased efficacy at lower concentrations compared to monofunctional therapy. Non-competitive blockade of the NMDA ... [more ▼]

Bifunctional drug therapy targeting distinct receptor signaling systems can generate increased efficacy at lower concentrations compared to monofunctional therapy. Non-competitive blockade of the NMDA receptors or the potentiation of AMPA receptors is well documented to result in memory enhancement. Here, we compared the efficacy of the low-affinity NMDA receptor blocker memantine or the positive modulator of AMPA receptor QXX (in C57BL/6J at 1 or 5 mg/kg, ip) with new derivatives of isothiourea (0.5-1 mg/kg, ip) that have bifunctional efficacy. Low-affinity NMDA blockade by these derivatives was achieved by introducing greater flexibility into the molecule, and AMPA receptor stimulation was produced by a sulfamide-containing derivative of isothiourea. Contextual learning was examined in a step-down avoidance task and extinction of contextual memory was studied in a fear-conditioning paradigm. Memantine enhanced contextual learning while QXX facilitated memory extinction; both drugs were effective at 5 mg/kg. The new derivative IPAC-5 elevated memory scores in both tasks at the dose 0.5 mg/Kg and exhibited the lowest IC50 values of NMDA receptor blockade and highest potency of AMPA receptor stimulation. Thus, among the new drugs tested, IPAC-5 plicated the properties of memantine and QXX in one administration with increased potency. Our data suggest that a concomitant manipulation of NMDA- and AMPA-receptors results in pro-cognitive effects and supports the concept bifunctional drug therapy as a promising strategy to replace monofunctional therapies with greater efficacy and improved compliance. [less ▲]

Detailed reference viewed: 5 (2 ULg)
Full Text
Peer Reviewed
See detailObjective: remission of depression in primary care The Oreon Study.
Ansseau, Marc ULg; Demyttenaere, Koen; Heyrman, Jan et al

in European Neuropsychopharmacology (2009), 19(3), 169-76

OBJECTIVE: Treatment of depression should result in the absence of symptoms, i.e. remission, in order to restore the functional status of the patient and reduce the risk for relapse. The study assessed ... [more ▼]

OBJECTIVE: Treatment of depression should result in the absence of symptoms, i.e. remission, in order to restore the functional status of the patient and reduce the risk for relapse. The study assessed the current remission rates in primary care and determined the influencing factors. METHODS: 10 consecutive depressive patients treated by antidepressants for at least 3 months and not more than 12 months were screened by each investigator. Remission rates were defined using the Hamilton-Depression scale 7 items (score of 3 or less) as well as the Carroll self rating scale (score of 7 or less). In addition, patients completed the Sheehan Disability Scale (SDS). Initial severity of depression, type of treatment and socio-economic factors were collected. RESULTS: 292 general practitioners screened a total of 2630 patients. Results indicated low remission rates: 28.3% according to the clinician and 17.1% according to the patient. Absence of remission was associated with higher impairment in work, social and family life. The most frequently reported residual symptoms in nonremitters were general somatic symptoms (92%), depressed mood (92%), psychic anxiety (91%) and impaired work and activities (89%). No differences were observed in remission rates between men and women. Remission rates were significantly lower in patients living alone as compared to those living in couple or family (25.1% vs 30.2%, p=0.03), in patients with lower education (21.3% vs 32.3%, p<0.001), in patients speaking French as compared to Dutch (24.0% vs 34.0% p<0.001), and unemployed patients compared to patients having an occupation (17.1% vs 39.0%, p<0.001). Higher initial severity and number of previous episodes decreased remission rates (p<0.001). CONCLUSION: This study shows low remission rates in depressed patients treated in general practice. The absence of remission is associated with impairment in work, social and family life. Special attention should be given to identify patients who do not reach remission. [less ▲]

Detailed reference viewed: 64 (16 ULg)
Full Text
Peer Reviewed
See detailA cross-sectional study of adiponectin in patients with schizophrenia
Hanssens, L.; De Hert, M.; Van Eyck, D. et al

in European Neuropsychopharmacology (2006, September), 16(Suppl. 4), 430-431

Detailed reference viewed: 18 (5 ULg)
Full Text
Peer Reviewed
See detailEvaluation of the metabolic safety of aripiprazole
De Hert, M.; Van Eyck, D.; Hanssens, L. et al

in European Neuropsychopharmacology (2006, September), 16(Suppl. 4), 399

Detailed reference viewed: 8 (4 ULg)
Full Text
Peer Reviewed
See detailScreening for metabolic abnormalities in patients with schizophrenia treated with antipsychotics: are we doing enough?
Van Winkel, R.; De Hert, M.; Van Eyck, D. et al

in European Neuropsychopharmacology (2006, September), 16(Suppl. 4), 398

Detailed reference viewed: 9 (4 ULg)
Full Text
Peer Reviewed
See detailOXYTOCIN, VASOPRESSIN AND ANXIETY IN MAJOR DEPRESSION: AGO-ANTAGONIST NEUROHROMONES
Scantamburlo, Gabrielle ULg; Hansenne, Michel ULg; Fuchs, Sonia et al

in European Neuropsychopharmacology (2006), 16

Detailed reference viewed: 32 (1 ULg)
Full Text
Peer Reviewed
See detailRapid diabetes onset and its reversal among patients treated with second generation antipsychotics
De Hert, M.; Van Eyck, D.; Hanssens, L. et al

in European Neuropsychopharmacology (2005, October), 15(Suppl. 3), 483-484

Detailed reference viewed: 24 (6 ULg)
Full Text
Peer Reviewed
See detailSix-month incidence of diabetes among schizophrenic patients in Belgium
Hanssens, L.; De Hert, M.; Van Eyck, D. et al

in European Neuropsychopharmacology (2005, October), 15(Suppl. 3), 483

Detailed reference viewed: 14 (6 ULg)
Full Text
Peer Reviewed
See detailPlasma oxytocin and anxiety in depressed patients
Scantamburlo, Gabrielle ULg; Fuchs, Sonia; Pitchot, William ULg et al

in European Neuropsychopharmacology (2005, October), 15(Suppl. 3), 430

Detailed reference viewed: 12 (2 ULg)
Full Text
Peer Reviewed
See detailNeurophysins response to apomorphine and clonidine in major depression
Scantamburlo, Gabrielle ULg; Ansseau, Marc ULg; Legros, Jean-Jacques ULg

in European Neuropsychopharmacology (2005, March), 15(Suppl. 1), 77-78

Detailed reference viewed: 5 (4 ULg)
Full Text
Peer Reviewed
See detailDissociation between the locomotor and anxiolytic effects of acetaldehyde in the elevated plus-maze : evidence that acetaldehyde is not involved in the anxiolytic effects of ethanol in mice
Tambour, Sophie ULg; Didone, Vincent ULg; Tirelli, Ezio ULg et al

in European Neuropsychopharmacology (2005), 15(6), 655-662

Acetaldehyde, the first product of ethanol metabolism, has been suggested to play a major role in many behavioral effects of ethanol. However, very few studies have directly tested the behavioral effects ... [more ▼]

Acetaldehyde, the first product of ethanol metabolism, has been suggested to play a major role in many behavioral effects of ethanol. However, very few studies have directly tested the behavioral effects of the acute administration of acetaldehyde. In particular, the role of this metabolite in ethanol-induced anxiolytic effects has never been extensively tested. The aim of the present study was to characterize the anxiolytic effects of acetaldehyde in two strains of mice, C57BL/6J and CD1 mice with the elevated plus-maze procedure. The results show that acute injections of ethanol (1-2 g/kg) induced significant dose-dependent anxiolytic effects in both strains of mice. In contrast, acetaldehyde failed to produce any anxiolytic effect, although it induced a significant hypolocomotor effect at the highest doses. In an independent experiment, cyanamide, an aldehyde dehydrogenase inhibitor, prevented the locomotor stimulant effects of ethanol, although it failed to alter its anxiolytic effects. Together, the results of the present study indicate that acetaidehyde is not involved in ethanol-induced anxiolytic effects, although it may be involved in its sedative/hypolocomotor effects. (c) 2005 Elsevier BX and ECNP. All fights reserved. [less ▲]

Detailed reference viewed: 35 (8 ULg)
Peer Reviewed
See detailSubacute effects of sertraline on attentional and executive functions in major depression
Constant, E. L.; Adam, Stéphane ULg; Gillain, B. et al

in European Neuropsychopharmacology (2004, October), 14(Suppl. 3), 198-199

Detailed reference viewed: 25 (6 ULg)
Full Text
Peer Reviewed
See detailNeurohypophyseal response to apomorphine and clonidine stimulation in major depression
Scantamburlo, Gabrielle ULg; Fuchs, Sonia; Pitchot, William ULg et al

in European Neuropsychopharmacology (2004, October), 14(Suppl. 3), 291-292

Detailed reference viewed: 9 (2 ULg)
See detailTherapeutic application of right prefrontal low repetitive transcranial magnetic stimulation on depressed patients
Fuchs, S.; Reggers, Jean ULg; Pinto, Emmanuel ULg et al

in European Neuropsychopharmacology (2004, October), 14(Suppl. 3), 226

Detailed reference viewed: 19 (5 ULg)
Full Text
Peer Reviewed
See detailEffects of acute and repeated administration of a cholinesterase inhibitor on timing behaviour
Bouger, P. C.; Spowart-Manning, L.; Ferrara, André ULg et al

in European Neuropsychopharmacology (2004), 14(4), 285-294

It has been hypothesised that a leftward shift in the response distribution obtained in the peak interval (PI) procedure is a characteristic of cognitive enhancement in which mental processes are speeded ... [more ▼]

It has been hypothesised that a leftward shift in the response distribution obtained in the peak interval (PI) procedure is a characteristic of cognitive enhancement in which mental processes are speeded. Metrifonate, a cholinesterase inhibitor with reported cognitive enhancing properties in many animal models of learning and memory, was tested in the PI procedure. Acute administration of 3 and 60 mg/kg but not 1 and 30 mg/kg in fully trained rats shifted the response distribution to the right, whereas subchronic administration of 10, 30 or 50 mg/kg during task acquisition had no effect on timing behaviour. On the basis of the present data, it can be concluded that the effects of a cognition enhancer in the PI procedure cannot be predicted from the scalar expectancy theory (SET). Furthermore, SET does not appear to be an appropriate tool for analysing the acquisition of timing behaviour. (C) 2003 Elsevier B.V/ECNP. All rights reserved. [less ▲]

Detailed reference viewed: 9 (3 ULg)
Full Text
Peer Reviewed
See detailRelationships between DRD2 and DAT polymorphisms and personality traits in healthy subjects
Pinto, Emmanuel ULg; Reggers, Jean ULg; Adam, Martine ULg et al

in European Neuropsychopharmacology (2003, September), 13(Suppl. 4), 427-428

Detailed reference viewed: 26 (2 ULg)
Full Text
Peer Reviewed
See detailSensitised locomotion does not predict conditioned locomotion in cocaine-treated mice: further evidence against the excitatory conditioning model of context-dependent sensitisation
Tirelli, Ezio ULg; Tambour, Sophie ULg; Michel, Anne

in European Neuropsychopharmacology (2003), 13(4), 289-296

The excitatory conditioning model of contextual sensitisation proposes that the progressive emergence of the locomotion-activating effect of cocaine (or any other stimulant drug) characterising that ... [more ▼]

The excitatory conditioning model of contextual sensitisation proposes that the progressive emergence of the locomotion-activating effect of cocaine (or any other stimulant drug) characterising that phenomenon is due to a growing conditioned response (the test context cues) that mimics the unchanging unconditioned response (the drug effect). The present study aimed at verifying whether the relationship between the amplitude of sensitisation and the size of the conditioned response was positive, a direct implication of that view. Sensitisation to the locomotion-activating effect of cocaine (10 mg/kg, s.c.) was firstly generated over 10 daily sessions in 25 mice (strain C57131/6J), another lot of 25 mice receiving the same dose of cocaine outside of the testing context. Conditioned locomotion was assessed 24 h later. No significant linear correlations were found between the magnitude of the conditioned response and the magnitude of the sensitised response (delta scores), the rate of sensitisation (individual regression coefficients) or the magnitude of the initial unconditioned response to cocaine (scores in the first session of sensitisation treatment). Accordingly, there was no significant correlation between the magnitude of the initial unconditioned response and the magnitude of the sensitised response or that of the initial unconditioned response. Therefore, the conditioned response is neither necessary nor sufficient for the development of context-dependent sensitisation of the locomotion-activating effect of cocaine, a conclusion that refutes the excitatory conditioning model of that chronic effect. (C) 2003 Elsevier B.V./ECNP. All rights reserved. [less ▲]

Detailed reference viewed: 8 (1 ULg)
Full Text
Peer Reviewed
See detailTaurine and ethanol preference : a microdialysis study using Sardinian alcohol-preferring and non-preferring rats
Quertemont, Etienne ULg; Lallemand, Frédéric; Colombo, Giancarlo et al

in European Neuropsychopharmacology (2000), 10

Recent intracerebral microdialysis studies of different rat brain regions have shown that an acute ethanol injection induced a rapid dose-dependent increase in taurine microdialysate content during the ... [more ▼]

Recent intracerebral microdialysis studies of different rat brain regions have shown that an acute ethanol injection induced a rapid dose-dependent increase in taurine microdialysate content during the first 60-min period. In taurine-supplemented rats, a reduced aversion for high ethanol doses was observed in a place conditioning paradigm, suggesting that taurine may be implicated in the regulation of some adverse effects of ethanol. The present study compares the effects of acute ethanol injections (1.0 and 2.0 g/ kg, i.p.) on taurine nucleus accumbens microdialysate content in Sardinian ethanol-preferring (sP) and Sardinian ethanol-non preferring (sNP) rats. While neither saline nor 1.0 g/kg ethanol injections had significant effect on taurine microdialysate concentration, 2.0 g/kg ethanol administration induced a rapid and significant increase in taurine microdialysate content in both sP and sNP rats. However, this ethanol-induced taurine release was significantly reduced in sP rats by comparison to sNP rats. As taurine is suggested to be released by brain cells to modulate different ethanol adverse effects, this lower taurine responsiveness to ethanol in sP rats by comparison to both sNP and Wistar rats may be a relevant indicator of reduced ethanol aversive effects in such animals and therefore be related to their higher alcohol consumption. [less ▲]

Detailed reference viewed: 13 (1 ULg)
Full Text
Peer Reviewed
See detailInterregional correlation of cerebral glucose metabolism in unmedicated schizophrenia
Biver, Françoise; Goldman, Serge; De Maertelaer, Viviane et al

in European Neuropsychopharmacology (1996), 6(2), 141-147

To investigate metabolic relationships between different brain regions in schizophrenia, we measured regional brain metabolism using positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG) in ... [more ▼]

To investigate metabolic relationships between different brain regions in schizophrenia, we measured regional brain metabolism using positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG) in 15 unmedicated schizophrenic patients and 15 healthy subjects. We analyzed correlations between glucose metabolism data of multiple brain regions using factorial analysis and correlation coefficient comparisons. Absolute regional intercorrelations in schizophrenic brains were found to be significantly stronger than in controls, in relationship to the greater variability of metabolic rates in schizophrenic patients. Variability of normalized metabolic rates and regional intercorrelations were not significantly different between schizophrenic patients and control subjects. We conclude that a global metabolic factor accounts for the variability of metabolic data in untreated schizophrenia. [less ▲]

Detailed reference viewed: 16 (1 ULg)