References of "Early Human Development"
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See detailOnce-a-day administration of amikacin in neonates: clinical evidence of the validity of a pharmacokinetic according to the gestational age
Battisti, Oreste ULg; Wallemacq P; Langhendries JP

in Early Human Development (1994), 38

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See detailCerebral hyperperfusion following episodes of bradycardia in the preterm infant
RAMAEKERS, Vincent ULg; Casaer, P.; Daniels, H.

in Early human development (1993), 34(3), 199-208

The alterations in cerebral hemodynamics during and following 39 episodes with bradycardia of different severity have been studied by analysis of Doppler flow velocity waveforms amongst 16 stable preterm ... [more ▼]

The alterations in cerebral hemodynamics during and following 39 episodes with bradycardia of different severity have been studied by analysis of Doppler flow velocity waveforms amongst 16 stable preterm infants (range of conceptional age at the time of study 33-39 weeks; weight 1730-2820 g). Each episode with bradycardia has been classified as mild on seven occasions (heart rate between 100-120 beats/min), moderate on 15 occasions (80-100), or severe on 17 occasions (heart rate below 80) Depending on the severity of the bradycardia, the time-averaged mean flow velocity (V) could decrease by 80% below the preexistent baseline value and the end-diastolic velocity (D) dropped towards the zero line, whereas peak systolic velocities did not change The magnitude of the percentage decrease of V correlated positively with the severity of bradycardia, indicating a progressive decline of cerebral blood flow (CBF). Following bradycardia, V could increase up to 75% above the preexistent baseline value. Simultaneously, an increase of mean arterial blood pressure and D could be documented. Peak systolic velocities remained unaltered. The magnitude of the percentage increase of V following bradycardia depended both on the severity of bradycardia as well as on the drop in transcutaneous oxygen during the preceding bradycardia. Interpretation of these findings suggested that the transient cerebral hyperperfusion following bradycardia compensates for the hypoxic-ischemic episode, sustained during the preceding epoch of apnea and bradycardia. [less ▲]

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See detailThe influence of blood transfusion on brain blood flow autoregulation among stable preterm infants.
RAMAEKERS, Vincent ULg; Casaer, P.; Daniels, H. et al

in Early human development (1992), 30(3), 211-20

Prior to and 24 h following blood transfusion serial determinations of both cerebral artery flow velocity waveforms and mean arterial blood pressure have been used to reconstruct the autoregulatory curve ... [more ▼]

Prior to and 24 h following blood transfusion serial determinations of both cerebral artery flow velocity waveforms and mean arterial blood pressure have been used to reconstruct the autoregulatory curve and its upper blood pressure limit among five stable preterm infants. Prior to transfusion the autoregulatory range of cerebral blood flow (CBF) was narrow due to a relatively low-set upper blood pressure limit. At 24 h after transfusion each individual has been re-examined. Following correction of anemia both a significant reduction of CBF velocities as well as a concomitant rise of the Pulsatility Index (PI) occurred over the entire range of blood pressures indicating a reduction of CBF after transfusion. In addition a right-sided shift of the upper limit towards higher mean blood pressures occurred after transfusion and resulted in an extension of the autoregulatory plateau of CBF. These favourable effects of blood transfusion ameliorating autoregulation of brain blood flow particularly at higher blood pressures might well bear important therapeutic perspectives in our effort to prevent intracranial haemorrhage among sick preterm infants. [less ▲]

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See detailUpper limits of brain blood flow autoregulation in stable infants of various conceptional age.
RAMAEKERS, Vincent ULg; Casaer, P.; Daniels, H. et al

in Early human development (1990), 24(3), 249-58

In healthy adults cerebral blood flow is autoregulated and kept constant over a wide range of mean arterial blood pressures (MAP) between 60 and 150 mmHg. In 27 stable infants with different conceptional ... [more ▼]

In healthy adults cerebral blood flow is autoregulated and kept constant over a wide range of mean arterial blood pressures (MAP) between 60 and 150 mmHg. In 27 stable infants with different conceptional ages ranging from 33 to 50 weeks, Doppler measurements of mean flow velocity at the anterior cerebral artery have been recorded simultaneously with mean arterial blood pressures (MAP) during a period of 6 h. The range of autoregulation and its upper limit could thus be determined. The upper limit was found to increase with advancing age. In the infants with conceptional ages between 33 and 35 weeks, the upper limit of autoregulation varied between 45 and 60 mmHg, while the upper limit shifted to a MAP of 100 mmHg at 47 weeks conceptional age. A significant positive linear relationship existed between the upper limit of autoregulation and conceptional age. [less ▲]

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See detailThe influence of behavioural states on cerebral blood flow velocity patterns in stable preterm infants.
RAMAEKERS, Vincent ULg; Casaer, P.; Daniels, H. et al

in Early human development (1989), 20(3-4), 229-46

Previous Doppler ultrasound studies assessing cerebral blood flow velocities in the anterior cerebral artery (ACA) among healthy term and preterm infants, showed a widespread range for the calculated flow ... [more ▼]

Previous Doppler ultrasound studies assessing cerebral blood flow velocities in the anterior cerebral artery (ACA) among healthy term and preterm infants, showed a widespread range for the calculated flow indices. However, only one of these studies accounted for the infant's behavioural state. In the present study a stable pattern of the cerebral blood flow velocity tracings and of the Pulsatility Index (PI) was observed during state 1, whereas marked fluctuations in cerebral blood flow velocity and PI were found during state 4 or active wakefulness. During state 2, minor variations of cerebral blood flow velocity and PI occurred though tended to be less pronounced than during active wakefulness. Thus at the time of Doppler assessment the cerebral blood flow velocity pattern and its variability will be better understood by taking into account the behavioural state of the infant. [less ▲]

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See detailBrain growth in sick preterm neonates: a real time ultrasound study
Battisti, Oreste ULg; Bachy, A.; Gérard, P.

in Early Human Development (1986), 13

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See detailChanging of blood culture isolates in neonates
Battisti, Oreste ULg; Oto, A.; Mitchison, R. et al

in Early Human Development (1980)

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