Adult-like neurobehavioral changes induced by a GABA-A agonist in infant and weanling mice

in Developmental Brain Research (1991), 61(2), 207-215

Neurobehavioral responsivity to peripherally injected muscimol, a gamma-aminobutyric acid-A (GABA-A) agonist, was assessed in infant (14-day-old), weanling (20-day-old), and young adult (53-day-old ... [more ▼]

Neurobehavioral responsivity to peripherally injected muscimol, a gamma-aminobutyric acid-A (GABA-A) agonist, was assessed in infant (14-day-old), weanling (20-day-old), and young adult (53-day-old) outbred male mice. In Exp 1, relatively high doses of muscimol (0.05-0.40 mg/kg in developing and 0.50-3 mg/kg in adult Ss) were found to dose-dependently induce solid catalepsy and ataxia. In Exp 2, the GABA agonist was injected in dose ranges that included relatively small concentrations to assess its excitatory properties, observable in adults, on rearing and locomotion in developing mice. Levels of rearing and especially locomotion were enhanced at low doses (0.025-0.050 mg/kg in developing and 1.3-2.9 mg/kg in adult mice) and inhibited at higher ones (0.150 mg/kg in developing and 1.9 and 2.5 mg/kg in adult mice). ((c) 1997 APA/PsycINFO, all rights reserved) [less ▲]

dynamic structure of the radial glial fiber system of the developing murine cerebral wall.an immunocytochemical analysis

in Developmental Brain Research (1989), 50

mitotic cycling of radial glial cells of the fetal murine cerebral wall: a combined autoradiographic and immunohistochemical study.

in Developmental Brain Research (1988), 38