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See detailPotential use of estetrol in sensorineural hearing loss protection
DELHEZ, Amandine ULg; Manfroid, Isabelle ULg; LEFEBVRE, Philippe ULg et al

in B-ENT (2017)

Introduction and Aims: Estrogens have a positive impact on the auditory function. Indeed, estradiol (E2) treatment in animals protects against acoustic trauma and aminoglycoside toxicity and its depletion ... [more ▼]

Introduction and Aims: Estrogens have a positive impact on the auditory function. Indeed, estradiol (E2) treatment in animals protects against acoustic trauma and aminoglycoside toxicity and its depletion can contribute to age-related hearing loss. However, estradiol is not suitable in clinical practice, given the increased risk of cancer and thromboembolic events. There is a need to find new treatments that present a higher benefit/risk ratio. In this work, we studied a new natural estrogen derivative, estetrol (E4), that was shown to act as a Selective Estrogen Receptor Modulator (SERM). Estetrol is thus able to display estrogen-like as well as antiestrogen activity depending on the target tissue. Interestingly, E4 allows the prevention of menopause symptoms such as osteoporosis or hot flushes through an agonistic action, whereas it exerts anti-estrogenic effects on the mammary gland. These preclinical data suggest that E4 presents a safer profile than E2. Material and Methods: To investigate whether this molecule presents otoprotective actions, we exposed P2 cultured organs of Corti to gentamicin, with or without estetrol (E4). After 48 hours of culture, hair cell survival was evaluated following anti-myosin VII Immunohistochemistry. We next moved on to in vivo studies using young zebrafish larvae (5dpf), since they constitute a highly effective model to determine the potential ototoxicity of drugs and to screen for candidates of hair cell protective agents. We monitored the survival of hair cells within neuromasts following chronic or acute exposure to gentamicin. Results: In cochlear culture, gentamicin-induced hair cell loss was significantly reduced by E4. Interestingly, the toxicity of aminoglycoside was also reduced in vivo upon treatment of zebrafish larvae with E4. Conclusion: The survival rate of hair cells was increased in the presence of estetrol both in vitro and in vivo indicating that estetrol constitutes an interesting protective drug against hearing loss. [less ▲]

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See detailFunctional respiratory imagning-aided virtual preoperative planning in nasal surgery: towards a personalized approach.
Ansari, Edward; Vos, Wim; Van Holsbeke, Cedric et al

in B-ENT (2016)

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See detailValidation of the Dutch version of the Sino-Nasal Outcome Test-22 (SNOT-22) Questionnaire
Cox, Caroline; Vanderveken, Olivier; Wouters, K et al

in B-ENT (2014)

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See detailSudden sensorineural hearing loss: when ophthalmology meets otolaryngology.
Karelle, S.; Demanez, L.; Zangerle, P. F. et al

in B-ENT (2012), 8(2), 135-9

OBJECTIVES: Sudden sensorineural hearing loss is a perplexing entity in otology. Susac's syndrome (also called retinocochleocerebral vasculopathy) is a rare disorder that consists of microangiopathy of ... [more ▼]

OBJECTIVES: Sudden sensorineural hearing loss is a perplexing entity in otology. Susac's syndrome (also called retinocochleocerebral vasculopathy) is a rare disorder that consists of microangiopathy of the brain, retina, and inner ear, and usually affects women in young adulthood. We describe the clinical aspects, radiographic findings, and management of one such case. CASE REPORT: A 30-year-old woman was admitted to the hospital because of sudden onset of bilateral deafness and headache. During her hospitalization, she developed discrete right hemiparesis and hypoesthesia. RESULTS: Magnetic resonance imaging revealed multiple signal hyperintensities and atrophy of the corpus callosum. The differential diagnosis was a myelinating condition, such as multiple sclerosis or acute demyelinating encephalomyelitis. CONCLUSION: Retinal fluorescein angiography helped the diagnosis of Susac's syndrome. [less ▲]

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See detailPosteroanterior Cephalometry in Obstructive Sleep Apnoea
POIRRIER, Anne-Lise ULg; Pire, Sylvie; Raskin, Sylviane et al

in B-ENT (2011)

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See detailType III frontal sinusotomy: surgical technique, indications, outcomes, a multi-university retrospective study of 120 cases.
Eloy, P.; Vlaminck, S.; Jorissen, M. et al

in B-ENT (2011), 7 Suppl 17

Draf in 1991. The procedure--which is also known as the modified endoscopic Lothrop procedure--aims to create the largest possible anteroposterior and lateral to lateral opening between both frontal ... [more ▼]

Draf in 1991. The procedure--which is also known as the modified endoscopic Lothrop procedure--aims to create the largest possible anteroposterior and lateral to lateral opening between both frontal sinuses and the nasal cavities. This requires the resection of the medial floor of both frontal sinuses, the intersinus septum and the superior nasal septum. The authors present a retrospective study including a cohort of 120 patients who underwent surgery in six Belgian university ENT departments. Mean follow-up was 24.6 months (range: 5-36 months). This paper describes the surgical procedure and reviews the indications, comorbidities, outcomes and complications of the type III frontal sinusotomy. Some correlations are also established with the data published in the worldwide literature. The authors conclude that the Draf III is a demanding procedure requiring considerable expertise in endoscopic sinus surgery. The procedure is effective with a success rate of 87.5%. Indeed, 12.5% of patients only experienced closure of the neoostium while 20% of all the patients had unchanged or worse symptomatology. The percentage of post-operative complications is 7.5%. All complications were managed successfully. [less ▲]

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See detailPertussis in adulthood.
POIRRIER, Anne-Lise ULg; TROMME, Noelle ULg; LEFEBVRE, Philippe ULg et al

in B-ENT (2009)

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See detailTreating allergic rhinitis: continuous versus on-demand regime? Executive summary of the Supportive Initiatives for the Global Management of Allergy (SIGMA): report from the Belgian Working Group
Church, M. K.; Watelet, J. B.; Cataldo, Didier ULg et al

in B-ENT (2009), 5(12), 1-25

This Supportive Initiative for the Global Management of Allergy (SIGMA) initiative gathered together four multidisciplinary and inter-university groups of Belgian experts in the treatment of allergic ... [more ▼]

This Supportive Initiative for the Global Management of Allergy (SIGMA) initiative gathered together four multidisciplinary and inter-university groups of Belgian experts in the treatment of allergic rhinitis to review the literature and come to a consensus opinion on the global management of allergy. Their conclusions were as follows. Group 1 concluded that in children suffering from allergic rhinitis, there is sufficient expert opinion in favour of continuous treatment with both H1-antihistamines and corticosteroids for controlling symptoms during periods of allergen exposure, but not to support continuous treatment during periods when symptoms are negligible in an attempt to prevent the development of new allergic diseases. Group 2 came to similar conclusions in adults. Group 3 considered adults with concomitant asthma and stressed the crucial necessity to screen each asthmatic for allergic rhinitis and institute appropriate therapy for both conditions. Even though efficacious treatment algorithms are available for both rhinitis and asthma, an integrated management of these frequently concomitant diseases is not always prescribed even though there is a proven clinical advantage of adequate treatment of the nose of asthmatics. Group 4 concluded that for both H1-antihistamines and nasal corticosteroids, safety data indicate that continuous treatment may be given without fears of adverse consequences. With regard to the cost implications of continuous therapy versus on-demand therapy, there are indications that effective treatment of allergic rhinitis by continuous treatment reduces overall drug costs, particularly that of escape medication and indirect costs in the form of days absent from work and school. [less ▲]

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See detailEricksonian hypnosis in tinnitus therapy.
Maudoux, Audrey ULg; Bonnet, Sophie ULg; Lhonneux-Ledoux, F. et al

in B-ENT (2007), 3 Suppl 7

OBJECTIVE: To evaluate the effect of Ericksonian therapy on tinnitus STUDY DESIGN: Non-randomised, prospective longitudinal study. SETTING: Tertiary referral centre. PATIENTS: A total of 49 patients ... [more ▼]

OBJECTIVE: To evaluate the effect of Ericksonian therapy on tinnitus STUDY DESIGN: Non-randomised, prospective longitudinal study. SETTING: Tertiary referral centre. PATIENTS: A total of 49 patients underwent hypnosis therapy. Fourteen patients failed to finish the therapy (drop-out rate: 35%). Of the 35 patients who completed the therapy, 20 were male and 15 female. The average age was 46.3 years (range 17-78). INTERVENTION: The treatment is based on the principles and approaches of Ericksonian hypnosis. The first session was mainly dedicated to the evaluation of the impact of tinnitus on the patient's life and to an explanation of hypnosis therapy. The next sessions were "learning sessions" based on relaxation and mental imaging. Exercises were first based on all senses other than hearing. Then they focused on hearing, teaching patients how to modulate sound intensity, and finally how to modulate tinnitus intensity. Patients also learnt self-hypnosis. MAIN OUTCOME MEASURE(S): To evaluate the effect of the treatment, tinnitus was assessed with the Tinnitus Handicap Inventory questionnaire before and after the therapy. Results: After 5 to 10 sessions (mean: 8.09 + -1.92) of Ericksonian hypnosis therapy, the 35 patients were capable of self-hypnosis with the aim of modulating their tinnitus, and the measured THI score fell for all patients. The global score improved significantly from 60:23 before EH therapy to 16.9 at discharge. Within the group, the initial score was distributed as follows: 0% slight, 14% mild, 31% moderate, 31% severe and 23% catastrophic. The t-test for dependent variables revealed significant improvements in all subgroups (p < or = 0.005). CONCLUSIONS: The results of this clinical trial demonstrate that Ericksonian hypnosis, in particular using self-hypnosis, is a promising technique for treating patients with tinnitus. [less ▲]

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See detailSudden deafness : a diagnosis can hide another one.
POIRRIER, Anne-Lise ULg; DEMANEZ, Laurent CH P ULg; Zangerle, Pierre François et al

in B-ENT (2006)

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See detailSpeech discrimination and intelligibility: outcome of deaf children fitted with hearing aids or cochlear implants.
Lejeune, Brigitte ULg; Demanez, Laurent

in B-ENT (2006), 2(2), 63-68

We retrospectively studied outcome of a sample of 36 congenitally deaf children who were fitted with either a conventional hearing aid or a cochlear implant and who received many years of audio-phonatory ... [more ▼]

We retrospectively studied outcome of a sample of 36 congenitally deaf children who were fitted with either a conventional hearing aid or a cochlear implant and who received many years of audio-phonatory training.To rate auditory capacity and speech intelligibility, we used commonly used metrics: CAP and SIR. At the end of the 5-Years period, CAP and SIR scores of cochlear implant children are significantly higher than those of conventional hearing aid children. This study is one of few that evaluates outcome of conventional hearing aid and cochlear implant fitting with age matched congenitally deaf children anno 2000. [less ▲]

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See detailSynovial sarcoma of the larynx: case report and literature review.
Boniver, V.; MOREAU, Pierre ULg; Lefèbvre, Philippe ULg

in B-ENT (2005), 1(1), 47-51

Synovial sarcoma is a rare mesenchymal malignancy which represents 8.5% of all soft tissue sarcomas and usually occurs in the lower extremities of young adults. Because the incidence in the head and neck ... [more ▼]

Synovial sarcoma is a rare mesenchymal malignancy which represents 8.5% of all soft tissue sarcomas and usually occurs in the lower extremities of young adults. Because the incidence in the head and neck region is very low, only 13 patients with endolaryngeal localisation have been reported so far. We present here a case of aryepiglottic synovial sarcoma. The tumour was completely resected, under suspension micro-laryngoscopy, using a CO2 laser. No recurrence was observed three years after the surgery. Complete surgical excision is the treatment of choice. The role of chemotherapy and radiotherapy is still debated. However, this tumour has a poor prognosis because of the occurrence of distant metastasis. [less ▲]

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