References of "Advanced Engineering Materials"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailSystematic processing of β – tricalcium phosphate for efficient protein loading and in vitro analysis of antigen uptake
Ozhukil Kollath, Vinayaraj ULg; De Geest, Bruno; Mullens, Steven et al

in Advanced Engineering Materials (2013), 15(4), 295-301

Microparticulate calcium phosphate (CaP) powders are promising drug carriers because of their biocompatibility and degradability under physiological conditions. The adsorption capability of CaP ... [more ▼]

Microparticulate calcium phosphate (CaP) powders are promising drug carriers because of their biocompatibility and degradability under physiological conditions. The adsorption capability of CaP microparticles makes them interesting candidates, within the inorganic carrier materials, for delivering protein antigens to professional antigen presenting cells (APC) for vaccination purpose. However, in order to bind and deliver a sufficient amount of protein, the challenge is to effectively increase the binding capacity of this material. In this study, b-tricalcium phosphate (b-TCP) powder is engineered to obtain microparticles with increased protein loading, using bovine serum albumin as a model antigen. The decrease in particle size and increase in specific surface area of carrier is shown to strongly affect protein adsorption. Finally, we demonstrate that the processed b-TCP is capable of delivering its protein payload in vitro to dendritic cells, which are professional APCs and the target cell population for microparticulate vaccines. [less ▲]

Detailed reference viewed: 38 (13 ULg)
Full Text
Peer Reviewed
See detailHigh-Resolution Microfocus X-Ray Computed Tomography for 3D Surface Roughness Measurements of Additive Manufactured Porous Materials
Kerckhofs, Greet ULg; Pyka, Grzegorz; Moesen, Maarten et al

in ADVANCED ENGINEERING MATERIALS (2013), 15(3), 153-158

Since commercially available profiling systems fail when determining the surface roughness of porous materials, we propose a novel protocol for surface roughness quantification of 3D additive manufactured ... [more ▼]

Since commercially available profiling systems fail when determining the surface roughness of porous materials, we propose a novel protocol for surface roughness quantification of 3D additive manufactured porous structures based on high-resolution microfocus X-ray computed tomography (micro-CT) images. It allows to non-destructively assess the roughness of these porous materials at the outer surface as well as inside the structure. The noise in the images and the spatial image resolution both have a significant effect on the accuracy of the micro-CT-based roughness measurements. Comparing the roughness parameters of flat substrates determined both with commercially available (optical and contact) profiling systems and the micro-CT-based roughness measurement protocol shows that micro-CT can be applied accurately and in a robust manner for surface roughness quantification of 3D additive manufactured porous materials with a micro-scale roughness. Depending on the dimensions of the roughness, the micro-CT acquisition parameters, i.e., frame averaging and spatial image resolution, need to be fine-tuned. Submicron-scale roughness can currently not be quantified. [less ▲]

Detailed reference viewed: 15 (4 ULg)
Full Text
Peer Reviewed
See detailSurface Modification of Ti6Al4V Open Porous Structures Produced by Additive Manufacturing
Pyka, Grzegorz; Burakowski, Andrzej; Kerckhofs, Greet ULg et al

in ADVANCED ENGINEERING MATERIALS (2012), 14(6), 363-370

Additive manufacturing techniques can be used to produce micro-porous structures with global morphological properties that are highly controlled through robust computer design. Despite these advantages ... [more ▼]

Additive manufacturing techniques can be used to produce micro-porous structures with global morphological properties that are highly controlled through robust computer design. Despite these advantages, most of these techniques still hold several functional constraints, resulting from present technical device limits and consequently the inability to control surface morphology at a microscale level. In this study, a novel protocol for surface modification of 3D titanium alloy-based open porous structures is developed, which applies a combination of chemical etching (CHE) and electrochemical polishing (ECP) using HF-based solutions. This protocol achieves significant and controllable roughness reduction of additive manufactured 3D Ti6Al4V open porous structures. Chemical etching mainly removes the attached powder grains, while ECP further decreases the roughness. In this way the heterogeneity of the strut surface roughness throughout the full 3D structure is effectively removed. [less ▲]

Detailed reference viewed: 13 (0 ULg)
Full Text
Peer Reviewed
See detailDip-coating of fibrous natural materials for alumina tube manufacturing
Gaydardzhiev, Stoyan ULg; Wilker, Viola; Scheffler, Michael

in Advanced Engineering Materials (2008), 10(3), 223-226

Results from preliminary studies for development of hollow ceramic tubes by dip-coating of fibrous plants with water based gel-casting slurries are presented. Hemp and coconut fibres have been tested as ... [more ▼]

Results from preliminary studies for development of hollow ceramic tubes by dip-coating of fibrous plants with water based gel-casting slurries are presented. Hemp and coconut fibres have been tested as templates reflecting in different macro and micro structures of the obtained ceramic tubes. Good correlation between the diameters of the template fibres and the developed channels has been documented, the ordering of the channels inside the tubes being function of the mode of fibres implementation: as singles or as bundles. By coating hemp fibres in bundle, multi channel pattern has been developed, resulting from splitting of the bundle. By using single coconut fibre as template, uniform mono channels with 250 – 400 µm in diameter were observed. The developed tubes have been characterized by good end finish. The observed differences in their microstructure offer possibilities for adjusting the physical properties towards prospective application niches. [less ▲]

Detailed reference viewed: 134 (33 ULg)