References of "Acta Clinica Belgica. Supplementum"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailRevue des cas d'intoxication mortelle a la methadone: observations recensees au CHU de Liege
Denooz, Raphael ULg; Charlier, Corinne ULg

in Acta Clinica Belgica. Supplementum (2006), 61(Suppl. 1), 32-36

All methadone-associated deaths from October 2002 to April 2005 are analysed. A regular increase in these fatal intoxications has been recorded, in Belgium as in other countries, due, in particular, to an ... [more ▼]

All methadone-associated deaths from October 2002 to April 2005 are analysed. A regular increase in these fatal intoxications has been recorded, in Belgium as in other countries, due, in particular, to an intensified prescription of this product, of which illicit use as street dope becomes problematic. Over the 30 months period covered by the study, 26 deaths related to methadone were listed, of which 3 occurred in accidental circumstances. In the other 23 cases, methadone can be found, yet always associated with psychotropic substances, mainly benzodiazepines (18 cases), narcotics (15 cases) and finally alcohol (5 cases). Based upon the nature of the products combined with methadone, records have been divided in two groups: In the first group (17 observations), xenobiotics at (infra)therapeutic levels are detected. In the other group (6 observations), xenobiotics at high and toxic levels are detected. Blood methadone concentrations are not so different between the 2 groups of individuals since the median values and the extreme values are worth respectively 308, and 110-11300 microg/L, for the first group and 776 and 93-2080 microg/L for the second group.There is thus an important overlap between the therapeutic blood methadone concentrations (150-400 microg/L) and blood concentrations observed in fatalities.Thus, it is necessary that all information and post-mortem results must be examined in a critical way to identify and justify cause of the death. [less ▲]

Detailed reference viewed: 112 (23 ULg)
Full Text
Peer Reviewed
See detailComparaison de trois approches pour l'estimation de l'incertitude.
Marini Djang'Eing'A, Roland ULg; Chiap, Patrice ULg; Boulanger, Bruno ULg et al

in Acta Clinica Belgica. Supplementum (2006), (1), 60-2

Three different approaches for the estimation of uncertainty measurements using the same analytical method were compared, namely validation, robustness and inter-laboratory studies. The uncertainty ... [more ▼]

Three different approaches for the estimation of uncertainty measurements using the same analytical method were compared, namely validation, robustness and inter-laboratory studies. The uncertainty obtained with the robustness study! predicted well the uncertainty of the inter-laboratory study. On the other hand, the uncertainty estimation obtained with the validation study is lower than those obtained with the two other approaches but is still acceptable as long as the analytical method will be used in a single laboratory. [less ▲]

Detailed reference viewed: 44 (7 ULg)
Full Text
Peer Reviewed
See detailHarmonisation des strategies de validation et estimation de l'incertitude associee dans le cadre de l'accreditation des laboratoires d'essais
Hubert, Philippe ULg; Rozet, Eric ULg; Boulanger, Bruno ULg et al

in Acta Clinica Belgica. Supplementum (2006), S1(1), 53-55

In order to achieve the harmonization of validation strategies, the interpretation of several validation criteria is proposed. Furthermore, a simple and visual decision tool to assess the validity of an ... [more ▼]

In order to achieve the harmonization of validation strategies, the interpretation of several validation criteria is proposed. Furthermore, a simple and visual decision tool to assess the validity of an analytical procedure is described: the accuracy profile based on the estimation of the total error of the measurements. This profile build with beta-expectation tolerance intervals can also compute with efficiency the uncertainty related to the results of a laboratory, which is an essential parameter for the accreditation of laboratories under ISO 17025. [less ▲]

Detailed reference viewed: 83 (18 ULg)
Full Text
Peer Reviewed
See detailLe transfert d'une methode de dosage automatisee de la noradrenaline dans l'urine humaine: utilisation de l'erreur totale comme critere de decision
Rozet, Eric ULg; Dewé, Walthère ULg; Chiap, Patrice ULg et al

in Acta Clinica Belgica. Supplementum (2006), (1), 57-9

Two new statistical approaches based on the total error of measurements were applied to the transfer of an automated method for the determination of noradrenalin in human urine by LC-ECD coupled on-line ... [more ▼]

Two new statistical approaches based on the total error of measurements were applied to the transfer of an automated method for the determination of noradrenalin in human urine by LC-ECD coupled on-line to SPE. They showed that the receiving laboratory was mastering the analytical procedure allowing it to use the method in routine. Furthermore the risk based approach gave guarantee that the risk to have future measurements out of specification in the receiving laboratory was smaller than 5%, therefore being a risk management tool. [less ▲]

Detailed reference viewed: 79 (9 ULg)
Full Text
Peer Reviewed
See detailEffets perturbateurs endocriniens des pesticides organochlorés
Charlier, Corinne ULg; Plomteux, Guy ULg

in Acta Clinica Belgica. Supplementum (2002), (1), 2-7

Xenoestrogens such organochlorine pesticides are known to induce changes in reproductive development, function or behaviour in wildlife. Because these compounds are able to modify the estrogens metabolism ... [more ▼]

Xenoestrogens such organochlorine pesticides are known to induce changes in reproductive development, function or behaviour in wildlife. Because these compounds are able to modify the estrogens metabolism, or to compete with estradiol for binding to the estrogen receptor, it may be possible that these products affect the risk of developing impaired fertility, precocious puberty or some kinds of cancer in man. [less ▲]

Detailed reference viewed: 156 (13 ULg)
Full Text
Peer Reviewed
See detailComparison of the stratus CS and Axsym analysers for determination of cardiac troponin I in plasma
Chapelle, Jean-Paul ULg; Aldenhoff, Marie-Claire ULg; Pierard, Luc ULg et al

in Acta Clinica Belgica. Supplementum (2000), (suppl.1), 14

Detailed reference viewed: 17 (0 ULg)
Full Text
Peer Reviewed
See detailAn association demonstrated between homocysteine, CRP and troponin levels in PTCA patients
Lutteri, Laurence ULg; Chapelle, Jean-Paul ULg; Gielen, Jacques

in Acta Clinica Belgica. Supplementum (1999), (suppl.1), 15

Detailed reference viewed: 7 (0 ULg)
Peer Reviewed
See detail"CAPCIL". Adaptation posologique des traitements par aminoglycosides
Gougnard, Thierry; Charlier, Corinne ULg; Plomteux, Guy ULg

in Acta Clinica Belgica. Supplementum (1999), 1

The objectives of the therapeutic drug monitoring are to assume the efficacy and inocuity of a medical treatment and the patient's observance. The administration of a drug to a patient is not always ... [more ▼]

The objectives of the therapeutic drug monitoring are to assume the efficacy and inocuity of a medical treatment and the patient's observance. The administration of a drug to a patient is not always performed in the same conditions and therefore treatment has to be adapted. When necessary, this one is very often based on empiric or very approximative notions and, more seldom, on results of plasmatic concentrations of the drug. The CAPCIL program allows the possibility to objectivate the medical decision and adapt the posology on the basis of two kinetic parameters: the biological half-life and the distribution volume. Indeed, most of pharmacokinetics modifications (drug interactions, diseases, ...) are affecting the two parameters. With basic informations so as height and weight, posology, treatment objectives and peak/trough plasmatic concentrations of the drug, the program is proposing several posology adaptation schemes. The example of a once-a-day administration of amikacin is discussed. [less ▲]

Detailed reference viewed: 33 (0 ULg)
Full Text
Peer Reviewed
See detailConcentrations plasmatiques de la vitamine K1 et de l'acenocoumarol en fonction du temps de quick (I.N.R.)
Gougnard, Thierry; Charlier, Corinne ULg; David, Jean-Louis ULg et al

in Acta Clinica Belgica. Supplementum (1999), S1

Reduced vitamins K are acting as cofactors of glutamic carboxylation of procoagulant factors (II, VII, IX and X). The reduction of these vitamins is inhibited by oral anticoagulants. The response to ... [more ▼]

Reduced vitamins K are acting as cofactors of glutamic carboxylation of procoagulant factors (II, VII, IX and X). The reduction of these vitamins is inhibited by oral anticoagulants. The response to antivitamins K is individual and may change during the treatment of a patient. The determinations of plasmatic vitamin K and acenocoumarol may help to explain the mechanism of a resistance to the anticoagulant therapy. Quantifications of vitamin K1 are realized after liquid-liquid extraction with liquid chromatography and fluorescence detection after post-column reduction. For acenocoumarol, plasma concentration is measured, after liquid-liquid extraction, by liquid chromatograph, with ion trap mass spectrometer detector. [less ▲]

Detailed reference viewed: 65 (3 ULg)
Peer Reviewed
See detailFrom obesity to type 2 diabetes.
Scheen, André ULg

in Acta Clinica Belgica. Supplementum (1992), 14

Obesity is a well-known risk factor for the development of non-insulin-dependent diabetes mellitus (NIDDM). Both insulin resistance and concomitant B-cell dysfunction are necessary for the development of ... [more ▼]

Obesity is a well-known risk factor for the development of non-insulin-dependent diabetes mellitus (NIDDM). Both insulin resistance and concomitant B-cell dysfunction are necessary for the development of NIDDM. Insulin resistance, probably genetically determined but worsened by obesity, appears to be the primary defect that leads to impaired glucose tolerance. However, B-cell dysfunction plays a critical role during progressive deterioration from mild impaired glucose tolerance to severe NIDDM. [less ▲]

Detailed reference viewed: 16 (0 ULg)