References of "Acta Cardiologica"
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See detailPractical recommendations on the use of echocardiography to assess pulmonary arterial hypertension--a Belgian expert consensus endorsed by the Working Group on Non-Invasive Cardiac Imaging.
LANCELLOTTI, Patrizio ULg; Budts, Werner; de Wolf, Daniel et al

in Acta Cardiologica (2013), 68(1), 59-69

Pulmonary hypertension (PH) is defined by a sustained increase in mean pulmonary arterial pressure > 25 mmHg. Due to its widespread availability, echocardiography (ECHO) is used as the first-line imaging ... [more ▼]

Pulmonary hypertension (PH) is defined by a sustained increase in mean pulmonary arterial pressure > 25 mmHg. Due to its widespread availability, echocardiography (ECHO) is used as the first-line imaging modality to detect pulmonary PH and assess right ventricular (RV) function in daily routine. As such, ECHO is the key examination to detect the presence of PH, to provide valuable prognostic information and to give an orientation to therapeutic strategies. In addition to detection and screening, ECHO also provides clues for the differential diagnosis of PH. The present document, based on a consensus of experts, provides practical recommendations for the use of ECHO in the evaluation of PH and of its consequences on the right ventricle. [less ▲]

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See detailThe quest for evidence "Beauty is truth, truth beauty"--that is all ye know on earth, and all ye need to know.
Ector, Hugo; LANCELLOTTI, Patrizio ULg

in Acta Cardiologica (2012), 67(1), 1-2

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See detailAortic coarctation treated by extraanatomic aortic bypass.
GARWEG, Christophe ULg; MELON, Pierre ULg; LANCELLOTTI, Patrizio ULg

in Acta Cardiologica (2010), 65(3), 365

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See detailAn alien in the heart: giant infective endocarditis.
Bataille, Yoann ULg; Moonen, Marie ULg; Lancellotti, Patrizio ULg

in Acta Cardiologica (2009), 64(6), 807-9

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See detailBelgian Society of Cardiology position paper on heart centres in Belgium.
Berkenboom, Guy; Budts, Werner; Claeys, Marc et al

in Acta Cardiologica (2009), 64(4), 537-9

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See detailSafety of ultrasound contrast agents: "Primum non nocere"?
Cosyns, Bernard; Pasquet, Agnes; Van Camp, Guy et al

in Acta Cardiologica (2009), 64(4), 547-52

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See detailBelgian expert opinion: how to reduce the residual risk in atherogenic dyslipidaemic patients: place of fibrates.
Ducobu, Jean; Scheen, André ULg; Van Gaal, Luc et al

in Acta Cardiologica (2008), 63(2), 235-48

The demographics of dyslipidaemia have changed towards a more complex atherogenic dyslipidaemia involving increased levels of LDL-C, in particular highly atherogenic small dense particles ... [more ▼]

The demographics of dyslipidaemia have changed towards a more complex atherogenic dyslipidaemia involving increased levels of LDL-C, in particular highly atherogenic small dense particles, hypertriglyceridaemia and low HDL, together with increased levels of markers of cardiovascular inflammation, thrombogenesis and endothelial dysfunction. Statins were shown to significantly lower cardiovascular morbidity and mortality, but there still remains a high residual risk in dyslipidaemic patients, in particular with metabolic syndrome, type 2 diabetes, or low HDL levels. Fibrates have been shown to reduce plasma triglycerides and increase HDL-C, while improving inflammation, thrombogenesis and endothelial dysfunction. Clinical trials with fibrates have demonstrated their potential to reduce cardiovascular morbidity and mortality too, often through other mechanisms than these of statins. Combination trials of statins with fibrates have shown a more complete improvement of lipid profile and risk markers than each class separately. In contrast with gemfibrozil, fenofibrate does not interact significantly with the pharmacokinetics of statins, and up to now its combination with statins has been shown to have a low risk of muscular side effects or liver toxicity. The ACCORD outcome trial is exploring the possible benefits of the combination of fenofibrate with statins on morbidity and mortality of patients with atherogenic dyslipidaemia. [less ▲]

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See detailEchocardiographic assessment of patients with heart failure: a practical checklist.
De Sutter, Johan; Herbots, Lieven; LANCELLOTTI, Patrizio ULg

in Acta Cardiologica (2008), 63(6), 783-9

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See detailEuropean National Society Cardiovascular Journals. Background, rationale and mission statement of the "Editors' Club" (Task Force of the European Society of Cardiology).
Alfonso, Fernando; Ambrosio, Giuseppe; Pinto, Fausto J. et al

in Acta Cardiologica (2008), 63(3), 281-7

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See detailDiagnostic accuracy of computed tomography coronary angiography in routine practice
Davin, Laurent ULg; LANCELLOTTI, Patrizio ULg; Bruyere, P. J. et al

in Acta Cardiologica (2007), 62(4), 339-344

Objectives - The recent newer advances in computed tomography have dramatically changed our approach to imaging cardiac disease. This study sought to compare the diagnostic value of 16-multi-detector ... [more ▼]

Objectives - The recent newer advances in computed tomography have dramatically changed our approach to imaging cardiac disease. This study sought to compare the diagnostic value of 16-multi-detector spiral computed tomography (MSCT) for detecting coronary artery stenosis. Methods - A total of 88 consecutive patients (52 men, mean age 68 +/- 8 years) with atypical chest pain, stable angina or suspicion of ischaemia at stress test were studied by MSCT and invasive coronary angiography (ICA). The MSCT images and multiplanar reconstructions were analysed regarding the presence of >= 50% coronary artery lesion. Results - All 88 scans obtained at a mean heart rate of 68 8 beats/min were interpretable. Sixteen coronary segments were evaluated in each patient. Of the 1320 segments examined, 148 (11 %) showed poor image quality. A total of 150 significant lesions were detected using ICA, and 80 of 150 (53%) were detected by MSCT Sensitivity, specificity, positive and negative predictive values were as follows: 53%, 97%, 68%, and 94%. Fifty-four patients had >= 50% coronary stenosis. The diagnosis was confirmed by MSCT in 42 patients and correctly ruled out in 30. By patient-based analysis, positive and negative predictive values were 91 % and 71 %. Conclusion - Although its specificity is high, the sensitivity of 16-slice MSCT for detecting 2: 50% coronary stenosis in non-selected patients submitted to ICA is rather low suggesting that for daily practice the diagnostic value of this technique should be improved. [less ▲]

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See detailQuantitative analysis of semi-supine exercise echocardiography - influence of age on myocardial Doppler imaging indices
Petropoulou, E.; LANCELLOTTI, Patrizio ULg; Pierard, L. A.

in Acta Cardiologica (2006), 61(3), 271-277

Objectives - This study was performed to evaluate the feasibility of quantitative analysis of exercise echocardiography using pulsed wave Doppler myocardial imaging (DMI) and to examine the relation ... [more ▼]

Objectives - This study was performed to evaluate the feasibility of quantitative analysis of exercise echocardiography using pulsed wave Doppler myocardial imaging (DMI) and to examine the relation between age and DMI parameters at rest and during graded exercise in normal subjects. Methods and results - Seventy-two healthy volunteers were divided into three age groups (group 1, age :5 40 years, group 11, age 41 - 59 years and group 111, age : 60 years), and underwent a semisupine exercise echocardiogram. Peak systolic velocity (SV), time to peak SV (TPV), systolic velocity time integral (VTI) and peak diastolic velocities (V-E and V-A) were measured off-line. There was a heterogeneity in DMI parameters between different myocardial walls and a gradient was found between basal and mid segments. Both persisted during exercise. Group I had significantly higher TPV than groups II and III. Increase in workload was accompanied by an increase in velocities, while TPV decreased. Differences between groups persisted throughout exercise. Conclusions - Off-line measurements of DMI parameters are feasible during exercise. SV and E decline as age increases while A increases. SV already increases at low charge exercise and may serve as a quantitative marker for the detection of myocardial viability. Change of the absolute DMI velocity values during exercise may provide a better indicator of ischaemia or viability than the absolute values themselves. [less ▲]

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See detailElectrocardiographic changes during dobutamine stress testing in patients with recent myocardial infarction: relation with residual infarct artery stenosis and contractile recovery
Lancellotti, Patrizio ULg; Mipinda, J. B.; Pierard, L. A.

in Acta Cardiologica (2004), 59(1), 11-16

OBJECTIVE: The identification of viable but jeopardized myocardium after acute myocardial infarction (AMI) is of great importance for selecting patients who could benefit from a revascularization ... [more ▼]

OBJECTIVE: The identification of viable but jeopardized myocardium after acute myocardial infarction (AMI) is of great importance for selecting patients who could benefit from a revascularization procedure. The aim of the study was to determine the accuracy of the dobutamine stress electrocardiogram (ECG) 1) for detecting significant stenosis of the infarct-related artery and 2) for predicting the occurrence of contractile recovery. METHODS AND RESULTS: Ninety-four patients underwent dobutamine stress ECG and quantitative angiography within the first week after AMI. A follow-up resting echocardiogram was obtained in all patients at 1 month. Significant stenosis of the infarct-related artery was detected in 76 patients and functional recovery occurred in 56 patients. Dobutamine stress induced ST-segment elevation in 44 patients, ST-segment depression in 17 and T-wave normalization in 34. Increase in QT dispersion and dobutamine ST elevation were more sensitive than chest pain and ST-segment depression (79% and 53% vs. 24% and 17%, respectively; p<0.05) for detecting significant infarct-related artery stenosis. Four independent variables were selected for predicting contractile recovery: > or = 20 ms increase in QT dispersion from baseline to low-dose dobutamine (p = 0.00016), dobutamine-induced ST-segment elevation (p = 0.0009), elective angioplasty of the infarct-related artery (p = 0.001) and T-wave normalization (p = 0.005). CONCLUSIONS: The analysis of predischarge dobutamine stress ECG is useful for predicting residual stenosis of the infarct-related artery and contractile recovery in the affected area. QT dispersion changes during the test are the most accurate parameter. [less ▲]

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See detailIdentification of viable myocardium early after acute myocardial infarction using closed-loop arbutamine echocardiography: comparison with positron emission tomography
PIERARD, Luc ULg; MELON, Pierre ULg; LANCELLOTTI, Patrizio ULg et al

in Acta Cardiologica (2001), 56(6), 387-394

Objective -This study sought to evaluate the safety and efficacy of arbutamine echocardiography in identifying contractile reserve and predicting functional improvement early after acute myocardial ... [more ▼]

Objective -This study sought to evaluate the safety and efficacy of arbutamine echocardiography in identifying contractile reserve and predicting functional improvement early after acute myocardial infarction (AMI). Methods and results - Seventeen patients with first AMI underwent arbutamine echocardiography 48 to 96 hours after AMI. Arbutamine was infused by a closed-loop delivery device. The heart rate slope was 4 beats/min and the heart rate target was 20 beats/min above baseline heart rate. A follow-up echocardiogram was obtained one month later. N- 13 ammonia and F- 18 FDG positron emission tomographic (PET) imaging were performed 6 2 days after AMI, before coronary angiography. Mean duration of arbutamine infusion was 6 2 min. There was no complication and there were no major side effects. Myocardial viability was identified with PET in 15 of the 17 patients. Contractile reserve was observed in 10 patients during arbutamine infusion. Functional recovery was identified in 12 patients. Sensitivity, specificity and accuracy of PET and arbutamine echocardiography for predicting functional recovery were 100%, 40%, 76% and 67%, 80%, 84%, respectively. Conclusions - Low-dose arbutamine stress testing is safe early after AMI. Contractile reserve can be rapidly identified by echo cardiography and is specific, but moderately sensitive for predicting reversible dysfunction. [less ▲]

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See detailAcute St-Segment Elevation in Neisseria Meningitis
Gach, Olivier ULg; LANCELLOTTI, Patrizio ULg; Pierard, L. A.

in Acta Cardiologica (2001), 56(5), 327-9

Meningitis due to Neisseria meningitidis occurred in a young man. On admission, he was in septic shock and the electrocardiogram revealed convex upwards ST-segment elevation in inferior and lateral leads ... [more ▼]

Meningitis due to Neisseria meningitidis occurred in a young man. On admission, he was in septic shock and the electrocardiogram revealed convex upwards ST-segment elevation in inferior and lateral leads. Rapid and complete normalisation of the ECG was observed and the patient had a favourable evolution with intensive therapy.The mechanisms of the ECG abnormalities in this disease are unclear. In this patient, ST-segment elevation was probably related to severe transmural ischaemia or prolonged coronary artery spasm as suggested by increase and decrease of cardiac enzymes and transient echocardiographic wall motion abnormalities without pericarditis. However, myocarditis could not be completely ruled out. [less ▲]

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See detailIncreased aortic compliance and energetic cost of cardiac ejection
Kolh, Philippe ULg; LAMBERMONT, Bernard ULg; GERARD, P et al

in Acta Cardiologica (1999), 53(6), 387

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See detailThe clinical signification of troponin T, troponin I, CK and CK-MB after coronary angioplsaty
Marechal, P.; Legrand, Victor ULg; Chapelle, Jean-Paul ULg et al

in Acta Cardiologica (1998), 53

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See detailAdverse effect of hyperinsulinemia on cardiovascular risk profile in middle-aged belgian population
Saint-Remy, Annie ULg; Scheen, André ULg; Jeanjean, Michel et al

in Acta Cardiologica (1998), 53(5), 299

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See detailTotal cholesterol levels during adolescence: results of a Belgian MONICA population
Paulus, D.; Saint-Remy, Annie ULg; Rorive, Georges ULg et al

in Acta Cardiologica (1997), 52(2), 182-183

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See detailHypertension and left ventricular hypertrophy
Krzesinski, Jean-Marie ULg; Rorive, Georges ULg; Van Cauwenberge, Henry

in Acta Cardiologica (1996), 51(2), 143-154

In response to high blood pressure, left ventricular hypertrophy develops. But in hypertension, the myocardial hypertrophied structure is abnormal. The prevalence of this hypertrophy is influenced by age ... [more ▼]

In response to high blood pressure, left ventricular hypertrophy develops. But in hypertension, the myocardial hypertrophied structure is abnormal. The prevalence of this hypertrophy is influenced by age, gender, weight, race, genetics and the severity of high blood pressure. By echocardiography, it has been possible to detect non invasively and more precisely this hypertrophy and its anatomical pattern which is not uniform. This cardiac response is influenced by hemodynamic but also by non hemodynamic factors, but the exact mechanisms are not yet well understood. The humoral and tropic factors particularly affect the cardiac remodeling. Left ventricular hypertrophy has been noted by itself to be an independent risk factor for sudden death, ventricular arrhythmias, myocardial ischemia, and heart failure. Very early hypertension, diastolic dysfunction is noted. The progression to systolic failure in moderate hypertension usually occurs over several decades. According to the worse prognosis of left ventricular hypertrophy, it has been suggested that the reversibility of this anatomical modification by antihypertensive treatment is beneficial. Preliminary data support this idea. [less ▲]

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