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See detailIndirect comparison of bazedoxifene vs oral bisphosphonates for the prevention of vertebral fractures in postmenopausal osteoporotic women.
Ellis, Alexandra G.; Reginster, Jean-Yves ULg; Luo, Xuemei et al

in Current medical research and opinion (in press)

Abstract Objective: Compare the efficacy of bazedoxifene with oral bisphosphonates for reduction of vertebral fracture risk in postmenopausal osteoporotic (PMO) women and in higher-risk patients based on ... [more ▼]

Abstract Objective: Compare the efficacy of bazedoxifene with oral bisphosphonates for reduction of vertebral fracture risk in postmenopausal osteoporotic (PMO) women and in higher-risk patients based on evidence from randomized controlled trials (RCTs). Methods: Eight RCTs assessing vertebral fracture risk reduction with oral bisphosphonates (n = 7) or bazedoxifene (n = 1) were identified by a systematic literature review. Individual study results were pooled in a network meta-analysis (NMA) to indirectly compare treatment effects for overall PMO women and a higher-risk subgroup (FRAX >/= 20%). Three sets of NMA analyses were conducted: aggregate data (AD) from the bisphosphonate RCTs and bazedoxifene RCT for the full population or the FRAX >/=20% subgroup (NMA AD); bisphosphonate AD and bazedoxifene AD from each FRAX subgroup adjusted for baseline risk (NMA AD meta-regression); and bisphosphonate AD and bazedoxifene individual patient data (IPD) adjusted for baseline risk/FRAX (NMA AD/IPD meta-regression). Results: For the overall population, bisphosphonates had lower fracture risks versus bazedoxifene although there is considerable uncertainty in supporting one intervention over another. The relative risk reduction (RRR) for bazedoxifene was -0.23 (95% CrI: -1.11, 0.27) versus ibandronate, -0.17 (-0.76, 0.22) versus alendronate, and -0.06 (-0.62, 0.30) versus risedronate. Results from the meta-regression analyses were similar. For the FRAX >/=20% population, estimated fracture rates with bazedoxifene were lower than with bisphosphonates, but again the uncertainty limits strong interpretation. The RRR for bazedoxifene was 0.51 (-0.31, 0.83) versus ibandronate, 0.53 (-0.18, 0.83) versus alendronate, and 0.57 (-0.07, 0.85) versus risedronate. The meta-regression analyses showed comparable findings. Conclusion: The analyses only considered vertebral fractures for oral bisphosphonates versus bazedoxifene, and IPD was available only for bazedoxifene. In light of this, bazedoxifene is comparable to bisphosphonates in the overall PMO population and at least as effective as bisphosphonates for preventing vertebral fractures among higher-risk PMO patients. The findings suggest bazedoxifene performs better in higher-risk PMO than in the overall PMO. [less ▲]

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See detailLe rôle des ecclésiastiques dans les armées françaises d’Italie à l’époque du Grand Schisme d’Occident (1382-1411)
Masson, Christophe ULg

in Actes du colloque Armée et religion, XVe–XIXe siècles (in press)

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See detailMesurer les distances entre des textes pré-carolingiens linguistiquement non-normés: le cas de la Passion de sainte Marine
Philippart de Foy, Caroline ULg; Goullet, Monique

in Etudes Classiques (Namur, Belgium) (in press)

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See detailChronique bibliographique - Supplément 2005-2008
Veymiers, Richard ULg; Bricault, Laurent; Malaise, Michel et al

in Bricault, Laurent; Veymiers, Richard (Eds.) Bibliotheca Isiaca III (in press)

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See detailGismondi, Ernesto
Prina, Daniela ULg

in Atkinson, Harriet; Edwards, Clive; Kettley, Sarah (Eds.) et al Encyclopedia of Design (in press)

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See detailMendini, Alessandro
Prina, Daniela ULg

in Atkinson, Harriet; Edwards, Clive; Kettley, Sarah (Eds.) et al Encyclopedia of Design (in press)

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See detailDynamic single-cell analysis of Saccharomyces cerevisiae under process perturbation: comparison of different methods for monitoring the intensity of population heterogeneity
Delvigne, Frank ULg; Baert, Jonathan ULg; Gofflot, Sébastien et al

in Journal of Chemical Technology & Biotechnology (in press)

BACKGROUND: Single cell biology has attracted a lot of attention these past few years and has led to numerous fundamental results pointing out the heterogeneity of clonal cell populations. In this context ... [more ▼]

BACKGROUND: Single cell biology has attracted a lot of attention these past few years and has led to numerous fundamental results pointing out the heterogeneity of clonal cell populations. In this context, microbial phenotypic heterogeneity under bioprocessing conditions needs to be further investigated. In this study, yeast based processes have been investigated by using on-line flow cytometry in combination with a fluorescent transcriptional reporter (GFP) and viability fluorescence tags (propidium iodide, PI). Methods aiming at expressing the dispersion of these fluorescence tags among the yeast populations have been investigated for different bioreactor operating conditions. RESULTS: Yeast viability was determined on the basis of PI uptake. Segregation between PI negative and positive subpopulations could be efficiently quantified on the basis of the mean-to-median ratio or the amplitude of the interquartile range. On the other hand, the same quantification could not be made for the segregation occurring at the level of GFP synthesis. Indeed, when cells were exposed to sub-lethal or mild stresses (such as in scale-down reactors) two GFP subpopulations could be visualized by real-time FC, but quantification by one of the above-mentioned methods was not possible. CONCLUSIONS: Yeast population heterogeneity was observed in representative bioreactor operating conditions. Difficulties for the determination of segregation at the level of GFP synthesis point out the fact that one needs to understand the segregation mechanisms for the applied fluorescent reporters, to judge whether simple mathematical tools may be applied or if more sophisticated computational tools are needed for the quantification of the microbial population segregation. [less ▲]

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See detailLes "nouvelles" règles générales d'exécution des marchés publics. Commentaire de l'arrêté royal du 14 janvier 2013
Kohl, Benoît ULg; Leroy, S.

in Durviaux, Ann-Lawrence (Ed.) La réforme du droit des marchés publics (in press)

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See detailMaison Magnette
Prina, Daniela ULg

in Charlier, Sébastien; Moor, Thomas (Eds.) Guide d’architecture moderne et contemporaine à Liège (in press)

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See detailHigh TMEM45A expression is correlated to epidermal keratinization
Hayez, Aurélie; Malaisse, Jérémy; Rogiers, Edith et al

in Experimental Dermatology (in press)

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See detailHigh concentrations of Myeloperoxidase in the equine uterus as an indicator of endometritis
Parrilla Hernandez, Sonia ULg; Ponthier, Jérôme ULg; Franck, Thierry ULg et al

in Theriogenology (in press)

Intra-luminal fluid and excessive abnormal hyper-edema are regularly used for the diagnosis of endometritis in the mare, which is routinely confirmed by the presence of neutrophils on endometrial smears ... [more ▼]

Intra-luminal fluid and excessive abnormal hyper-edema are regularly used for the diagnosis of endometritis in the mare, which is routinely confirmed by the presence of neutrophils on endometrial smears. Studies show a relation between neutrophils and myeloperoxidase (MPO), an enzyme contained in and released by neutrophils during degranulation or after cell lysis. This enzyme has been found in many fluids and tissues and associated with different inflammatory pathologies in the horse. The aims of this study were to assess the presence and concentration of MPO in the equine uterus, and to investigate its relation with neutrophils, and other clinical signs of endometritis. Mares (n=51) were evaluated for presence of intra-luminal fluid and excessive endometrial edema before breeding, and a small volume lavage and cytology samples were obtained. From 69 cycles, supernatant of the uterine flushes was analysed with a specific equine MPO ELISA assay to measure MPO concentration. Cytology samples were used for the diagnosis of endometritis. MPO was present in the uterus of all estrus mares in highly variable concentrations. MPO concentrations were significantly (p<0.05) higher in samples with positive cytologies and in presence of intra-luminal fluid. Occasionally, some samples with negative cytologies showed high MPO concentration, but the opposite was never observed. Cycles presenting hyper-edema weren’t associated to high concentration of MPO, intra-luminal fluid or positive cytology making it a poor diagnostic tool of endometritis. [less ▲]

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See detailCarte géologique 34/5, Tongres
Mottequin, Bernard ULg; Marion, Jean-Marc ULg

Cartographic material (in press)

New version of the geological map of the sheet Tongeren-Herderen (no. 107) previously published at the scale of 1/40000 by Van den Broeck (1903)

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See detailCombining magnetic and seismic studies to constrain processes in massive stars
Neiner, C.; Degroote, P.; Coste, B. et al

in IAUS 302 - Magnetic Fields Throughout Stellar Evolution (in press)

The presence of pulsations influences the local parameters at the surface of massive stars and thus it modifies the Zeeman magnetic signatures. Therefore it makes the characterisation of a magnetic field ... [more ▼]

The presence of pulsations influences the local parameters at the surface of massive stars and thus it modifies the Zeeman magnetic signatures. Therefore it makes the characterisation of a magnetic field in pulsating stars more difficult and the characterisation of pulsations is thus required for the study of magnetic massive stars. Conversely, the presence of a magnetic field can inhibit differential rotation and mixing in massive stars and thus provides important constraints for seismic modelling based on pulsation studies. As a consequence, it is necessary to combine spectropolarimetric and seismic studies for all massive classical pulsators. Below we show examples of such combined studies and the interplay between physical processes. [less ▲]

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See detailAllogeneic stem cell transplantation for advanced cutaneous T-cell lymphomas: a study from the French Society of Bone Marrow Transplantation and French Study Group on Cutaneous Lymphomas
de Masson, Adele; Beylot-Barry, Marie; Bouaziz, Jean-David et al

in Haematologica (in press)

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See detailThe Role of Memory Traces Quality in Directed Forgetting: A Comparison of Young and Older Participants
Collette, Fabienne ULg; Grandjean, Julien; Lorant, Caroline ULg et al

in Psychologica Belgica (in press)

The presence of a reduced directed-forgetting (DF) effect in normal aging has been frequently observed with the item method. These results were interpreted as age-related difficulties in inhibiting the ... [more ▼]

The presence of a reduced directed-forgetting (DF) effect in normal aging has been frequently observed with the item method. These results were interpreted as age-related difficulties in inhibiting the processing of irrelevant information. However, since the performance of older adults is usually lower on items to remember, the age effect on DF abilities could also be interpreted as reflecting memory problems. Consequently, the present study aimed at investigating the influence of memory traces quality on the magnitude of the DF effects in normal aging. We predicted that increasing the quality of memory traces (by increasing presentation times at encoding) would be associated with attenuated DF effects in older participants due to the increased difficulty of inhibiting highly activated memory traces. A classical item-method DF paradigm was administered to 48 young and 48 older participants under short and long encoding conditions. Memory performance for information to memorize and to suppress was assessed with recall and recognition procedures, as well as with a Remember/Know/Guess (RKG) paradigm. The results indicated that, when memory traces are equated between groups, DF effects observed with the recall, recognition and RKG procedures are of similar amplitude in both groups (all ps>0.05). This suggests that the decreased DF effect previously observed in older adults might not actually depend on their inhibitory abilities but may rather reflect quantitative and qualitative differences in episodic memory functioning. [less ▲]

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See detailPassage Lemonnier
Prina, Daniela ULg

in Charlier, Sébastien; Moor, Thomas (Eds.) Guide d’architecture moderne et contemporaine à Liège (in press)

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See detailEffets d’amendements carbonatés et organiques sur la culture de deux légumes sur sol contaminé à Lubumbashi (RD Congo)
Mpundu Mubemba, Michel; Useni, Yannick; Nyembo, Lucien et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (in press)

Given the risks of contamination of the vegetables grown in gardens in the city of Lubumbashi due to soil pollution, agronomic solutions to reduce these risks have been experimented. The choice of ... [more ▼]

Given the risks of contamination of the vegetables grown in gardens in the city of Lubumbashi due to soil pollution, agronomic solutions to reduce these risks have been experimented. The choice of appropriate amendments (type and quantity) and the selection of plant varieties able to restrict transfers of trace metals (TM) from the soil to plant edible organs are part of the most conventional remediation techniques. Amaranth and spinach beet have been cultivated in pot trials according to randomized complete blocks with four replications on a contaminated soil that received different doses of liming and/or organic products and slightly contaminated soil. Along with an effect on soil chemistry, the amendments have been effective in reducing the transfer of trace metals from soil to plant. The lime-based treatments were more effective than compost. TM levels in plants however remained high whatever the application of amendments and the question of food chain contamination remains posed. [less ▲]

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