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See detailA Systematic Review of Cost-Effectiveness Analyses of Drugs for Postmenopausal Osteoporosis.
Hiligsmann, Mickaël ULg; Evers, Silvia M.; Ben Sedrine, Wafa et al

in PharmacoEconomics (in press)

BACKGROUND: Given the limited availability of healthcare resources and the recent introduction of new anti-osteoporosis drugs, the interest in the cost effectiveness of drugs in postmenopausal ... [more ▼]

BACKGROUND: Given the limited availability of healthcare resources and the recent introduction of new anti-osteoporosis drugs, the interest in the cost effectiveness of drugs in postmenopausal osteoporosis remains and even increases. OBJECTIVE: This study aims to identify all recent economic evaluations on drugs for postmenopausal osteoporosis, to critically appraise the reporting quality, and to summarize the results. METHODS: A literature search using Medline, the National Health Service Economic Evaluation database and the Cost-Effectiveness Analysis Registry was undertaken to identify original articles published between January 1, 2008 and December 31, 2013. Studies that assessed cost effectiveness of drugs in postmenopausal osteoporosis were included. The Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement was used to assess the quality of reporting of these articles. RESULTS: Of 1,794 articles identified, 39 studies fulfilled the inclusion criteria. They were conducted in 14 different countries and nine active interventions were assessed. When compared with no treatment, active osteoporotic drugs were generally cost effective in postmenopausal women aged over 60-65 years with low bone mass, especially those with prior vertebral fractures. Key drivers of cost effectiveness included individual fracture risk, medication adherence, selected comparators and country-specific analyses. Quality of reporting varied between studies with an average score of 17.9 out of 24 (range 7-21.5). CONCLUSION: This review found a substantial number of published cost-effectiveness analyses of drugs in osteoporosis in the last 6 years. Results and critical appraisal of these articles can help decision makers when prioritizing health interventions and can inform the development of future economic evaluations. [less ▲]

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See detailTémoignages sur l’art vétérinaire dans les lettres conservées sur papyrus, sur ostraca et sur tablettes (IIIe s. avant notre ère – VIIe s. de notre ère)
Ricciardetto, Antonio ULg

in Doyen-Higuet, Anne-Marie; Van den Abeele, Baudouin (Eds.) « Chevaux, chiens, faucons : l’art vétérinaire antique et médiéval à travers les sources écrites, archéologiques et iconographiques ». Actes du IIIe Colloque international sur l’art vétérinaire antique et médiéval (Université Catholique de Louvain, Louvain-la-Neuve, 24-26 mars 2011) (in press)

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See detailExpression microarray as a tool to identify candidate blood biomarkers in horses suffering from inflammatory airway disease
Ramery, Eve ULg; Fraipont, Audrey ULg; Art, Tatiana ULg et al

in Veterinary Clinical Pathology (in press)

Background: Inflammatory airway disease (IAD) affects performance and well-being in horses. Diagnosis is primarily reached by bronchoalveolar lavage (BAL) cytology but this is invasive and requires ... [more ▼]

Background: Inflammatory airway disease (IAD) affects performance and well-being in horses. Diagnosis is primarily reached by bronchoalveolar lavage (BAL) cytology but this is invasive and requires sedation. Objectives: The purpose of this study was to identify candidate blood biomarkers of IAD using species-specific expression microarrays. Methods: Horse Gene Expression Microarrays were used to investigate global mRNA expression in circulating leukocytes from healthy and IAD-affected standardbreds and endurance horses. Results: Nine genes were significantly differentially regulated in standardbreds and 61 in endurance horses (P < 0.001). These genes were mainly related to inflammation (eg. ALOX15B, PLA2G12B and PENK), oxidant/antioxidant balance (eg. DUOXA2 and GSTO1-1) and stress (eg. V1aR, GRLF1, Homer-2 and MAOB). DUOXA2, ALOX15B, PLA2G12B, MAOB and GRLF1 variations of expression were further validated by RT-qPCR. The deregulation of the oxidant/antioxidant balance was demonstrated at the protein level by an increase of glutathione peroxidase (GPx) activity in heparinised whole blood of IAD-affected standardbreds (P = 0.0025) and endurance horses (P = 0.0028). There was good correlation (r = 0.7354) between BAL neutrophil percentage and whole blood GPx activity in all horses. Conclusions: There is accumulating evidence that, even when systemic clinical signs are not evident, circulating leukocyte gene expression can reflect responses of other tissues, leading to potential diagnostic applications in the future. Although not specific for IAD, whole blood GPx activity appears to reflect BAL neutrophil percentage. This finding should be further assessed by testing a larger number of horses. [less ▲]

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See detailToponymie et anthroponymie dans l'Atlas linguistique de la Wallonie
Baiwir, Esther ULg

in Germain, Jean; Tamine, Michel (Eds.) Actes du XVIe Colloque d'Onomastique de la Société française d’onomastique (SFO) (in press)

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See detailMethIS V. La valeur de la science. Pourquoi évaluer la recherche
Cormann, Grégory ULg; Dozo, Björn-Olav ULg; Polis, Stéphane ULg

Book published by Presses universitaires de Liège (in press)

Actes du colloque du 10 et 11 décembre 2009 qui s'est tenu à Liège à l'initiative du personnel scientifique

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See detailFlow bi-stability around stay cable's sheath: Impact of roughness and circularity defect in the critical regime
Benidir, Adel; Flamand, Olivier; Gaillet, Laurent et al

in Journal of Wind Engineering & Industrial Aerodynamics (in press)

The stay cables on cable-stayed bridges have been the subject of considerable research in order to understand the origins of the dry galloping phenomenon. Surface irregularity is one of the last ... [more ▼]

The stay cables on cable-stayed bridges have been the subject of considerable research in order to understand the origins of the dry galloping phenomenon. Surface irregularity is one of the last parameters that have not been thoroughly examined. This paper focuses on static wind tunnel tests on original High Density Polyethylene cable covers in a range of Reynolds numbers from the sub-critical regime to the critical, corresponding to values ranging from Re = 9.6x104 to Re = 3.3x105. The experiment consists in testing cable covers of various diameters in order to investigate the effect of surface irregularity (roughness and circularity defect) on the mechanism of dry galloping excitation. Previous studies reported that dry galloping is caused by the appearance of a negative pressure bubble on one side of the circular cylinder at the critical Reynolds number range, leading to a rapid drop in the drag coefficient and the appearance of a non-negligible lift force. The results of the present investigation demonstrate that there is a clear correlation between the single bubble pressure pattern and the circularity defect along the tube. They further show that surface roughness has little effect on the location of the bubble. The paper also treats the spatial and temporal correlation of the instantaneous pressure pattern along the tube with respect to the circularity defect. [less ▲]

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See detailGenetic parameters for mid-infrared methane indicators based on milk fatty acids in dairy cows
Kandel, Purna Bhadra ULg; Gengler, Nicolas ULg; Soyeurt, Hélène ULg

in Journal of Applied Animal Research (in press)

Dairy production is identified as a major source of methane (CH4) emissions. Selective breeding canbe one method used to mitigate CH4 emissions but practical and cheap measurement of this trait is not ... [more ▼]

Dairy production is identified as a major source of methane (CH4) emissions. Selective breeding canbe one method used to mitigate CH4 emissions but practical and cheap measurement of this trait is not currently available. The mid-infrared (MIR) prediction of milk fatty acids is relevant in this context. Five MIR methane indicators were derived from the literature and were calibrated from 600 samples analyzed by gas chromatography. Genetic parameters for these traits were estimated using single trait random regression test-day models from 619,265 records collected from 2007 to 2011 on 71,188 Holstein cows in their first three lactations. For the published indicator showing the highest relationship with the methane data (R2 = 0.88), the average daily heritability was 0.34±0.01, 0.37±0.01 and 0.34±0.01 for the first three lactations, respectively. The methane emission (g/day) was increased from beginning of lactation, reached at the highest in peak of lactation and decreased towards end of lactation. The largest differences between estimated breeding values (EBV) of sires having daughters in production eructing the highest and the lowest methane content was 21.80, 22.75 and 24.89 kg per lactation for the first three parities. Positive genetic correlations were estimated between indicator traits and milk fat and protein content. Low negative correlation was observed with milk yield. In conclusion, this study shows the feasibility to predict methane indicator traits by MIR. Moreover, the estimated genetic parameters suggest also a potential genetic variability of the quantity of methane eructed by dairy cows. [less ▲]

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See detailAssessment of Toll-like receptor 2, 4 and 9 SNP genotypes in canine sino-nasal aspergillosis
Mercier; Peters, Iain; Farnir, Frédéric ULg et al

in BMC Veterinary Research (in press)

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See detailGold nanorods coated with mesoporous silica shell as drug delivery system for remote near infrared light-activated release and potential phototherapy
Liu, Ji; Detrembleur, Christophe ULg; De Pauw-Gillet, Marie-Claire ULg et al

in Small (Weinheim an der Bergstrasse, Germany) (in press)

In this study, we report the synthesis of a nanoscaled drug delivery system, which is composed of a gold nanorod-like core and a mesoporous silica shell (GNR@MSNP) and partially uploaded with phase ... [more ▼]

In this study, we report the synthesis of a nanoscaled drug delivery system, which is composed of a gold nanorod-like core and a mesoporous silica shell (GNR@MSNP) and partially uploaded with phase-changing molecules (1-tetradecanol, TD, Tm 39 degrees C) as gatekeepers, as well as its ability to regulate the release of doxorubicin (DOX). Indeed, a nearly zero premature release is evidenced at physiological temperature (37 degrees C), whereas the DOX release is efficiently achieved at higher temperature not only upon external heating, but also via internal heating generated by the GNR core under near infrared irradiation. When tagged with folate moieties, GNR@MSNPs target specifically to KB cells, which are known to overexpress the folate receptors. Such a precise control over drug release, combining with the photothermal effect of GNR cores, provides promising opportunity for localized synergistic photothermal ablation and chemotherapy. Moreover, the performance in killing the targeted cancer cells is more efficient compared with the single phototherapeutic modality of GNR@MSNPs. This versatile combination of local heating, phototherapeutics, chemotherapeutics and gating components opens up the possibilities for designing multifunctional drug delivery systems. [less ▲]

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See detailAre Children Conservative, Liberal or Metacognitive? Preliminary Evidence for the Involvement of the Distinctiveness Heuristic in Decision Making
Geurten, Marie ULg; Willems, Sylvie ULg; Meulemans, Thierry ULg

in Journal of Experimental Child Psychology (in press)

The present experiment investigates whether young children are able to reduce their false recognition rate after distinctive encoding by implementing a strategic metacognitive rule. Seventy-two children ... [more ▼]

The present experiment investigates whether young children are able to reduce their false recognition rate after distinctive encoding by implementing a strategic metacognitive rule. Seventy-two children, aged 4, 6, and 9 years, studied two lists of unrelated items. One of these lists was visually displayed (picture condition) while the other was presented auditorily (word condition). After each study phase, participants completed recognition tests. Finally, they answered questions about their explicit knowledge of the distinctive-encoding effect. The results revealed that even the youngest children in our sample showed a smaller proportion of intrusions in the picture condition than in the word condition. Furthermore, the results of the signal detection analyses were consistent with the hypothesis that the lower rate of false recognitions after picture encoding results from the implementation of a conservative response criterion based on metacognitive expectations (distinctiveness heuristic). Moreover, the absence of correlation between children’s explicit knowledge of the distinctiveness rule and their effective use of this metacognitive heuristic seems to indicate that its involvement in memory decisions could be mediated by implicit mechanisms. [less ▲]

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See detailThey were Soldiers. Civil War, Lieux de Mémoire, and Anonymity through Aeschylus’ Persae and Seven against Thebes.
Caneva, Stefano ULg

in Hanratty, Conor; Ioannidou, Eleftheria (Eds.) Epidaurus Encounters II. Greek Drama, Ancient Theatre and Modern Performance (in press)

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See detailMagie et pharmacopée : l’utilisation des végétaux dans les papyrus iatromagiques grecs
de Haro Sanchez, Magali ULg

in Mythos (in press)

The iatromagical papyri, subgenus of the magical papyri, come from Egypt. From the 1st BC to AD the 7th, they appear in the form of formularies, spells copied from them, amulets and a private letter. For ... [more ▼]

The iatromagical papyri, subgenus of the magical papyri, come from Egypt. From the 1st BC to AD the 7th, they appear in the form of formularies, spells copied from them, amulets and a private letter. For many years, the study of these texts has been part of a research program of the Centre de Documentation de Papyrologie Littéraire (CeDoPaL) of the University of Liège. We will present here the results from the analysis of the content of the prescriptions with plants attested in the Greek iatromagical formularies. [less ▲]

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See detailLa fin du Paléolithique moyen dans le Nord de l’Europe : la question des origines du Lincombien-Ranisien-Jerzmanowicien
Flas, Damien ULg

in Depaepe, Pascal; Goval, Emilie; Koehler, Héloïse (Eds.) et al Les plaines du Nord-Ouest : carrefour de l’Europe au Paléolithique moyen ? (in press)

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See detailThe soundtrack of RR Lyrae in Omega Cen at high-frequency
Calamida, A.S.; Randall, S.K.; Monelli, M. et al

in Memorie della Società Astronomica Italiana : Journal of the Italian Astronomical Society (in press)

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See detailThe Gaia-ESO Survey and Massive Stars
Blomme, R.; Fremat, Y.; Gosset, Eric ULg et al

in IAU Symposium 307 (in press)

As part of the Gaia-ESO Survey (GES), a number of clusters will be observed that were chosen speci cally for their massive-star content. We report on the procedures we followed to determine the stellar ... [more ▼]

As part of the Gaia-ESO Survey (GES), a number of clusters will be observed that were chosen speci cally for their massive-star content. We report on the procedures we followed to determine the stellar parameters from the massive-star spectra of this survey. We intercompare the results from the di erent techniques used by the nodes of our group to determine these parameters and discuss some of the problems encountered. We present preliminary results for NGC 6705, NGC 3293, and Trumpler 14. We study microturbulence in A-type stars, we use the repeat observation to investigate binarity, and we determine cluster membership from the radial velocity information. The large number of massive-star spectra obtained by the Gaia-ESO Survey will allow us to critically test stellar evolution modelling [less ▲]

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See detailThe BNP and the FN. Between Islamophobia and the “defence” of democratic values
Jamin, Jérôme ULg

in Jackson, Paul (Ed.) The British Far Right in Transition: 1945 to Today (in press)

In this article Jérôme Jamin examines the ideological development of the British National Party (BNP) and the Front National (FN) since 9/11. He argues that if both parties have evolved towards discourses ... [more ▼]

In this article Jérôme Jamin examines the ideological development of the British National Party (BNP) and the Front National (FN) since 9/11. He argues that if both parties have evolved towards discourses more in line with democracy and liberal values, it can be explained by the opportunity the “threat” of Islam offered. After a reminder of the birth and the electoral evolution of the two parties, Jamin focuses on the perception and the definition of democracy as depicted in their manifestos and main public speeches. The study reveals an ethnic-styled perception of democracy at the BNP in opposition with a more civic perception at the FN, even if the analysis shows an ambiguity behind the use of the concept of “people” in the FN rhetoric mixing frequently “demos” and “ethnos”. The author confronts the combination of this new democratic rhetoric with the birth of Islam as a threat incompatible with “British democracy” in the United Kingdom and “Republican secularism” in France. In both parties, stereotypes of Islam are used to portray the BNP and the FN as defenders of a true and legitimate democracy and to a great extent, Jamin argues, “Islam” provided an unexpected opportunity to replace migrants, foreigners and Arabs with a new stereotype: the Muslim who threatens the separation between state and religion, equality between men and women, freedom of speech, and so on. Jamin concludes by emphasising that both parties required time to identify this new scapegoat. [less ▲]

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See detailEvaluation des processus de mise en oeuvre des plans de cohésion sociale: rapport final
Italiano, Patrick ULg; Fallon, Catherine ULg; Thiry, Aline ULg et al

Report (in press)

Ce rapport synthétise la recherche d'évaluation des plans de cohésion sociale de la région Wallonne quant à leur mise en oeuvre locale. Il couvre les aspects de gouvernance locale, de construction de ... [more ▼]

Ce rapport synthétise la recherche d'évaluation des plans de cohésion sociale de la région Wallonne quant à leur mise en oeuvre locale. Il couvre les aspects de gouvernance locale, de construction de partenariats public-associatif, d'évaluation participative, et d'une manière plus générale de l'articulation entre politique régionale et autonomie communale [less ▲]

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