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See detailManagement of osteoporosis of the oldest old.
Rizzoli, R.; Branco, J.; Brandi, M.-L. et al

in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (in press)

This consensus article reviews the diagnosis and treatment of osteoporosis in geriatric populations. Specifically, it reviews the risk assessment and intervention thresholds, the impact of nutritional ... [more ▼]

This consensus article reviews the diagnosis and treatment of osteoporosis in geriatric populations. Specifically, it reviews the risk assessment and intervention thresholds, the impact of nutritional deficiencies, fall prevention strategies, pharmacological treatments and their safety considerations, the risks of sub-optimal treatment adherence and strategies for its improvement. INTRODUCTION: This consensus article reviews the therapeutic strategies and management options for the treatment of osteoporosis of the oldest old. This vulnerable segment (persons over 80 years of age) stands to gain substantially from effective anti-osteoporosis treatment, but the under-prescription of these treatments is frequent. METHODS: This report is the result of an ESCEO (European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis) expert working group, which explores some of the reasons for this and presents the arguments to counter these beliefs. The risk assessment of older individuals is briefly reviewed along with the differences between some intervention guidelines. The current evidence on the impact of nutritional deficiencies (i.e. calcium, protein and vitamin D) is presented, as are strategies to prevent falls. One possible reason for the under-prescription of pharmacological treatments for osteoporosis in the oldest old is the perception that anti-fracture efficacy requires long-term treatment. However, a review of the data shows convincing anti-fracture efficacy already by 12 months. RESULTS: The safety profiles of these pharmacological agents are generally satisfactory in this patient segment provided a few precautions are followed. CONCLUSION: These patients should be considered for particular consultation/follow-up procedures in the effort to convince on the benefits of treatment and to allay fears of adverse drug reactions, since poor adherence is a major problem for the success of a strategy for osteoporosis and limits cost-effectiveness. [less ▲]

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See detailDescribing the ‘elusive’ : Availability, Preparation and Use of Anthocyanin Colourants in Mediaeval European Illuminators’ Workshops
Neven, Sylvie ULg; Sanyova, Jana

in Dubois, Hélène; Eyb-Green, Sigrid; Kroustallis, Stephanos (Eds.) et al Making and transforming art : changes in artists’ materials and practice (in press)

Anthocyanins are colorants which provide most of the blue, red and violet colours in numerous plants and fruits. Because of their great sensitivity to the slightest changes in pH and their instability in ... [more ▼]

Anthocyanins are colorants which provide most of the blue, red and violet colours in numerous plants and fruits. Because of their great sensitivity to the slightest changes in pH and their instability in ordinary daylight, it is generally thought that these colorants were used only to dye everyday clothes in a domestic context. However, medieval artists’ recipe books not only describe these elusive substances, but also indicate their use in illumination. This is notably the case for the texts of the so-called ‘Strasbourg Tradition’, written in the south of Germany and the north of France between 1400 and 1560, and partly composed from an older Alsatian treatise on illumination. Departing from these sources, this paper details the methods employed to prepare these colorants and (re)evaluates their diverse uses in painting and illuminating techniques. This technical data subsequently served as a basis upon which to make reconstructions. Finally, an attempt to correlate the information provided by these recipe books with specific artistic practices was carried out by collating the descriptions with the results of analyses from contemporary illuminations by an Alsatian workshop active in the same geographical area. [less ▲]

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See detailBrazil – EU Partnership: from high expectations to limited results
Santander, Sébastian ULg; Saraiva, Miriam

in European Journal of International Relations (in press)

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See detailMeteorological variation in daily travel behaviour: evidence from revealed preference data from the Netherlands
Creemers, Lieve; Wets, Geert; Cools, Mario ULg

in Theoretical & Applied Climatology (in press)

This study investigates the meteorological variation in revealed preference travel data. The main objective of this study is to investigate the impact of weather conditions on daily activity participation ... [more ▼]

This study investigates the meteorological variation in revealed preference travel data. The main objective of this study is to investigate the impact of weather conditions on daily activity participation (trip motives) and daily modal choices in the Netherlands. To this end, data from the Dutch National Travel Household Survey of 2008 were matched to hourly weather data provided by the Royal Dutch Meteorological Institute and were complemented with thermal indices to indicate the level of thermal comfort and additional variables to indicate the seasonality of the weather conditions. Two multinomial logit–generalised estimation equations (MNL-GEE) models were constructed, one to assess the impact of weather conditions on trip motives and one to assess the effect of weather conditions on modal choice. The modelling results indicate that, depending on the travel attribute of concern, other factors might play a role. Nonetheless, the thermal component, as well as the aesthetical component and the physical component of weather play a significant role. Moreover, the parameter estimates indicate significant differences in the impact of weather conditions when different time scales are considered (e.g. daily versus hourly based). The fact that snow does not play any role at all was unexpected. This finding can be explained by the relatively low occurrence of this weather type in the study area. It is important to consider the effects of weather in travel demand modelling frameworks because this will help to achieve higher accuracy and more realistic traffic forecasts. These will in turn allow policy makers to make better long-term and short-term decisions to achieve various political goals, such as progress towards a sustainable transportation system. Further research in this respect should emphasise the role of weather conditions and activityscheduling attributes. [less ▲]

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See detailTrifles for 'Unflemings'. Teaching Dutch Literary History in Nineteenth-Century Wallonia
Steyaert, Kris ULg

in Van Kalmthout, T.; Zuidervaart, H. (Eds.) The Practice of Philology in the Nineteenth-Century Netherlands (in press)

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See detailCapacitated Vehicle Routing Problem With Sequence Based Pallet Loading and Axle Weight Constraints
Pollaris, Hanne; Braekers, Kris; Caris, An et al

in EURO Journal on Transportation and Logistics (in press)

In this paper, we introduce and study the capacitated vehicle routing problem with sequence based pallet loading and axle weight constraints. To the best of our knowledge, it is the rst time that axle ... [more ▼]

In this paper, we introduce and study the capacitated vehicle routing problem with sequence based pallet loading and axle weight constraints. To the best of our knowledge, it is the rst time that axle weight restrictions are incorporated in a vehicle routing model. The aim of this paper is to demonstrate that incorporating axle weight restrictions in a vehicle routing model is possible and necessary for a feasible route planning. Axle weight limits impose a great challenge for transportation companies. Trucks with overloaded axles represent a signi cant threat for tra c safety and may cause serious damage to the road surface. Transporters face high nes when violating these limits. A mixed integer linear programming formulation for the capacitated vehicle routing problem with sequence based pallet loading and axle weight constraints is provided. Results of the model are compared to results of the model without axle weight restrictions. Computational experiments demonstrate that the model performs adequately and that the integration of axle weight constraints in vehicle routing models is required for a feasible route planning. [less ▲]

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See detailLes jugements de Dominique Lampson sur Jan Gossart et Lambert Lombard
Allart, Dominique ULg

in Delfosse, Annick; Glesener, Thomas (Eds.) Ecrire, lire et éduquer à la Renaissance, Hommage en l’honneur de Franz Bierlaire (in press)

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See detailSophistique et Philosophie: Platon, héritier de Protagoras
Gavray, Marc-Antoine ULg

Book published by Vrin (in press)

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See detailThe extension of Early Upper Palaeolithic with blade leaf-points (Lincombian-Ranisian-Jerzmanowician): the issue of Kostenki 8 level I
Flas, Damien ULg

in Ashton, Nick (Ed.) No Stone Unturned: Papers in Honour of Roger Jacobi (in press)

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See detailAmour tordu de la patrie. Érotique et politique dans Pompes funèbres de Jean Genet
Denis, Benoît ULg

in Dubois, Jacques (Ed.) Érotique et politique dans la prose française du XXe-XXIe siècle (in press)

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See detailSurfactant-assisted ultrasonic spray pyrolysis of nickel oxide and lithium-doped nickel oxide thin films, towards electrochromic applications
Denayer, Jessica ULg; Bister, Geoffroy; Simonis, Priscilla et al

in Applied Surface Science (in press)

Lithium-doped nickel oxide and undoped nickel oxide thin films have been deposited on FTO/glass substrates by a surfactant-assisted ultrasonic spray pyrolysis. The addition of polyethylene glycol in the ... [more ▼]

Lithium-doped nickel oxide and undoped nickel oxide thin films have been deposited on FTO/glass substrates by a surfactant-assisted ultrasonic spray pyrolysis. The addition of polyethylene glycol in the sprayed solution has led to improved uniformity and reduced light scattering compared to films made without surfactant. Furthermore, the presence of lithium ions in NiO films has resulted in improved electrochromic performances (coloration contrast and efficiency), but with a slight decrease of the electrochromic switching kinetics. [less ▲]

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See detailThe role of olfaction in wireworms: a review on foraging behavior and sensory apparatus
Barsics, Fanny ULg; Haubruge, Eric ULg; Francis, Frédéric ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (in press)

Introduction Integrated management of wireworms (Coleoptera: Elateridae) depends upon approaches applied both above- and belowground, and over several spatial scales. While foraging, these soil pests use ... [more ▼]

Introduction Integrated management of wireworms (Coleoptera: Elateridae) depends upon approaches applied both above- and belowground, and over several spatial scales. While foraging, these soil pests use biotic and abiotic signals to orientate towards target plant organs. Development of efficient techniques for implementation in integrated strategies relies upon improved knowledge of this process. In particular, an important step consists of elucidating the role of volatile organic compounds (VOC), emitted by belowground plant organs, in wireworm chemical ecology. This would have a positive impact on push-pull strategies and varietal selection developed against these insects. Literature In this work, we summarized the available data regarding wireworm foraging behavior as well as variables that should be considered when studying the potential role of plant-produced volatile semiochemicals. This includes CO2 gradients and other host-related cues, temperature, relative humidity and soil moisture, and wireworm physiological stage. We also review what is known of the sensory apparatus of wireworms, since this is involved in every step of the foraging process. Conclusion Some baseline data for studying VOC related wireworm foraging behavior exists. Using it as a tool in applied entomology should result in discovery of the semiochemicals that underpin trophic interactions involving these pests. However, most of the key pest species are not fully described with regards to the parameters detailed here. Obtaining accurate information to fill the current knowledge gaps will be needed in order to devise new integrated management strategies. [less ▲]

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See detailAn algorithm recommendation for the management of knee osteoarthritis in Europe and internationally: A report from a task force of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)
Bruyère, Olivier ULg; Cooper, C; Pelletier, JP et al

in Seminars in Arthritis & Rheumatism (in press)

Objectives: Existing practice guidelines for osteoarthritis (OA) analyze the evidence behind each proposed treatment but do not prioritize the interventions in a given sequence. The objective was to ... [more ▼]

Objectives: Existing practice guidelines for osteoarthritis (OA) analyze the evidence behind each proposed treatment but do not prioritize the interventions in a given sequence. The objective was to develop a treatment algorithm recommendation that is easier to interpret for the prescribing physician based on the available evidence and that is applicable in Europe and internationally. The knee was used as the model OA joint. Methods: ESCEO assembled a task force of 13 international experts (rheumatologists, clinical epidemiologists, and clinical scientists). Existing guidelines were reviewed; all interventions listed and recent evidence were retrieved using established databases. A first schematic flow chart with treatment prioritization was discussed in a 1-day meeting and shaped to the treatment algorithm. Fine-tuning occurred by electronic communication and three consultation rounds until consensus. Results: Basic principles consist of the need for a combined pharmacological and non-pharmacological treatment with a core set of initial measures, including information access/education, weight loss if overweight, and an appropriate exercise program. Four multimodal steps are then established. Step 1 consists of background therapy, either non-pharmacological (referral to a physical therapist for re-alignment treatment if needed and sequential introduction of further physical interventions initially and at any time thereafter) or pharmacological. The latter consists of chronic Symptomatic Slow-Acting Drugs for OA (e.g., prescription glucosamine sulfate and/or chondroitin sulfate) with paracetamol at-need; topical NSAIDs are added in the still symptomatic patient. Step 2 consists of the advanced pharmacological management in the persistent symptomatic patient and is centered on the use of oral COX-2 selective or non-selective NSAIDs, chosen based on concomitant risk factors, with intra-articular corticosteroids or hyaluronate for further symptom relief if insufficient. In Step 3, the last pharmacological attempts before surgery are represented by weak opioids and other central analgesics. Finally, Step 4 consists of end-stage disease management and surgery, with classical opioids as a difficult-to-manage alternative when surgery is contraindicated. Conclusions: The proposed treatment algorithm may represent a new framework for the development of future guidelines for the management of OA, more easily accessible to physicians. © 2014 The Authors. [less ▲]

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See detailDramatic osteonecrosis of the jaw associated with oral bisphosphonates, periodontitis and dental implant removal
Ayora, A F; HERION, Francine ULg; ROMPEN, Eric ULg et al

in Journal of Clinical Periodontology (in press)

Osteoporosis affects millions of elderly patients, and anti-resorptive drugs (ARD) such as bisphosphonates (BP) represent the first-line therapy. Despite the benefits related to the use of these ... [more ▼]

Osteoporosis affects millions of elderly patients, and anti-resorptive drugs (ARD) such as bisphosphonates (BP) represent the first-line therapy. Despite the benefits related to the use of these medications, osteonecrosis of the jaw is a significant complication in a subset of patients receiving these drugs. CASE PRESENTATION: This report documents a case of dramatic bisphosphonate-related osteonecrosis associated with periodontitis and dental implant removal in an osteoporotic patient treated with per os bisphosphonates for an uninterrupted period of 15 years. CONCLUSION: The aim of this report was to discuss the administration period of BP in the treatment of osteoporosis, the decision-making and clinical management of severe MRONJ and the indications for dental implant placement in these specific patients. [less ▲]

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See detailDocument Kinetic study of volatile oil of Curcuma longa L. rhizome and Carum carvi L. fruits extracted by microwave-assisted techniques using the cryogrinding
Akloul, R; Benkaci-Ali, F; Eppe, Gauthier ULg

in Journal of Essential Oil Research (in press)

Hydrodistillation assisted by microwave (HDAM) and steam distillation assisted by microwave (SDAM) of Curcuma longa L. rhizome (CL) and Carum carvi fruits (CC) were investigated. The effect of the ... [more ▼]

Hydrodistillation assisted by microwave (HDAM) and steam distillation assisted by microwave (SDAM) of Curcuma longa L. rhizome (CL) and Carum carvi fruits (CC) were investigated. The effect of the cryogrinding (CG) showed differences in yields and composition of volatile oils compared with classical grinding. HDAM–CG (CL: 1.20%, CC: 1.25%) and SDAM–CG (CL: 1.45%, CC: 1.75%) allowed extraction of substantial amounts of volatile oils in less time compared with HDAM (CL: 0.6%, CC: 1.00%) and SDAM (CL: 0.90%, CC: 1.00%). In addition, the major amounts of volatile oils were globally obtained during the first 5 and 10 minutes of extraction for CL and CC, respectively. A kinetic study of essential oils extraction from CL and CC was quantitatively performed. The composition of the major components and family classes present a significant variation with the extraction time. Essential oils extracted by these two methods were quantitatively (yield) and qualitatively [aromatic profile by gas chromatography (GC) and GC–mass spectrometry (GC–MS)] analyzed. There were differences, especially in the major compounds ar-turmerone (HDAM: 46.00–57.96%, HDAM–CG: 30.85–60.32%) and β-turmerone (HDAM: 14.43–16.74%, HDAM–CG: 10.46–15.77%) for CL, and limonene (HDAM: 23.61–56.97%, HDAM–CG: 38.04–43.00%) and carvone (HDAM: 36.19–64.54%, CC–CG: 53.65–56.31%) for CC. [less ▲]

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See detailHis cognitis vs. His cognitis rebus : ordre des constituants et bornage de l’Ablatif absolu
Longrée, Dominique ULg; Philippart de Foy, Caroline ULg; Purnelle, Gérald ULg

in Haverling, Gerd (Ed.) Proceedings of the 16th Int. Coll. on Latin Linguistics, Uppsala, 6-12 juin 2011 (in press)

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See detailPortrait dévotionnel et ascension spirituelle dans la peinture flamande du XVe siècle : le cas de la Vierge d’Exeter de Petrus Christus
Falque, Ingrid ULg

in BERGMANS, Luc (Ed.) La contempplation dans la peinture flamande (14e-16e siècles). Actes de la journée d'études organisée au Centre d'études supérieures de Tours (in press)

Consacré à la célèbre Vierge d’Exeter de Petrus Christus (Berlin, Gemäldegalerie), cet article vise à montrer que le tableau – commandé par le chartreux Jan Vos qui y apparaît en prière devant la Vierge – ... [more ▼]

Consacré à la célèbre Vierge d’Exeter de Petrus Christus (Berlin, Gemäldegalerie), cet article vise à montrer que le tableau – commandé par le chartreux Jan Vos qui y apparaît en prière devant la Vierge – comporte des références au thème de l’ascension spirituelle et visualise ainsi le progrès spirituel de Jan Vos. Ce dernier est représenté à l’entrée du palais céleste, où il est introduit par sa sainte patronne et accueilli par la Vierge. Il s’apprête ainsi à délaisser le monde terrestre, symbolisé par la ville représentée en contrebas, pour rejoindre le Christ et atteindre la béatitude éternelle, comme le préconise Gérard Zerbolt van Zutphen dans son De spiritualibus ascensionibus. Les données historiques relatives au dévot m’ont permis de découvrir qu’il a eu accès à plusieurs ouvrages traitant de l’évolution de la vie intérieure et plus précisément au texte de Zerbolt pendant son séjour long de plusieurs années à la chartreuse de Nieuwlicht. Le lien entre le tableau et le traité de Gérard Zerbolt est ainsi patent. [less ▲]

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See detailTrunk muscle profile in elite tennis players with and without low back pain
GROSDENT, Stéphanie ULg; Demoulin, Christophe ULg; Souchet, Matthieu et al

in Journal of Sports Medicine & Physical Fitness (in press)

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See detailDevelopment and validation of the French version of a tool assessing patient's expectations in lower limb osteoarthritis
NEUPREZ, Audrey ULg; Delcour, JP; Fatemi, F et al

in Journal of Orthopaedics (in press)

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See detailAn atomistic view of DNA dynamics and its interaction with small binders: insights from Molecular Dynamics and Principal Component Analysis
Fresch, Barbara ULg; Remacle, Françoise ULg

in Joachim, Christian (Ed.) Advances in Atom and Single Molecule Machines (in press)

DNA oligomers are promising building blocks for the development of bottom-up nano-devices and molecular logic machines. To control and exploit their unique capabilities of self-assembling and molecular ... [more ▼]

DNA oligomers are promising building blocks for the development of bottom-up nano-devices and molecular logic machines. To control and exploit their unique capabilities of self-assembling and molecular recognition a deep understanding of their dynamical properties is essential. We theoretically investigate the dynamics of a DNA dodecamer and its complexes with two common ligands, Hoechst33258 and the ethidium cation, by means of classical Molecular Dynamics (MD) simulations and Principal Component Analysis (PCA). We study the structural relation between the flexibility of the double helix and the binding process. The dynamics of a terminal base pair unbinding is also analysed as an example of process that involves multiple energy minima in the underlying free energy landscape. [less ▲]

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