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See detailMémoire épisodique dans la maladie d’Alzheimer : déclin de la recollection et de la familiarité ?
Simon, Jessica ULg; Bastin, Christine ULg

in Medecine Sciences : M/S (in press)

According to the dual-process recognition models, the retrieval of information from long-term memory is supported by recollection and familiarity. Alzheimer’s disease is consistently found to affect ... [more ▼]

According to the dual-process recognition models, the retrieval of information from long-term memory is supported by recollection and familiarity. Alzheimer’s disease is consistently found to affect recollection. As for familiarity, however, no consensus has been reached so far. Some studies are in favor of an early impairment of familiarity, while others are in favor of a preservation of familiarity in the mild and moderate stages of the disease. This lack of consensus can be partly explained by methodological differences between studies. We discuss three methodological dimensions: the type of recognition test, the type of paradigm for estimating familiarity and recollection, and the nature of the material used. These differences reveal the complex nature of familiarity which would be underlied by different mechanisms that may be selectively altered or preserved in the disease. [less ▲]

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See detailA European survey on attitudes towards pain and end-of-life issues in locked-in syndrome
Demertzi, Athina ULg; Jox, Ralf J; Racine, Eric et al

in Brain Injury (in press)

Objectives: Patients with locked-in syndrome often self-report a higher quality of life than generally expected. This study reports third-person attitudes towards several salient issues on locked-in ... [more ▼]

Objectives: Patients with locked-in syndrome often self-report a higher quality of life than generally expected. This study reports third-person attitudes towards several salient issues on locked-in syndrome. Methods: Close-ended survey among conference attendees from 33 European countries. Analysis included chi-square tests and logistic regressions. Results: From the 3332 respondents (33% physicians, 18% other clinicians, 49% other professions; 47% religious), 90% agreed that patients with locked-in syndrome can feel pain. The majority (75%) disagreed with treatment withdrawal, but 56% did not wish to be kept alive if they imagined themselves in this condition (p50.001). Religious and southern Europeans opposed to treatment withdrawal more often than non-religious (p50.001) and participants from the North (p¼0.001). When the locked-in syndrome was compared to disorders of consciousness, more respondents endorsed that being in a chronic locked-in syndrome was worse than being in a vegetative state or minimally conscious state for patients (59%) than they thought for families (40%, p50.001). Conclusions: Personal characteristics mediate opinions about locked-in syndrome. The dissociation between personal preferences and general opinions underlie the difference in perspective in disability. Ethical responses to dilemmas involving patients with locked-in syndrome should consider the diverging ethical attitudes of stakeholders. [less ▲]

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See detailOrganic Rankine Cycles including fluid selection
Lemort, Vincent ULg; Declaye, Sébastien ULg; Quoilin, Sylvain ULg

in Handbook of Clean Energy Systems (in press)

An Organic Rankine Cycle (ORC) is similar to a steam Rankine cycle, except that the working fluid is not water but an organic compound, such as a refrigerant or a hydrocarbon, characterized by a lower ... [more ▼]

An Organic Rankine Cycle (ORC) is similar to a steam Rankine cycle, except that the working fluid is not water but an organic compound, such as a refrigerant or a hydrocarbon, characterized by a lower ebullition temperature than that of water. Hence lower temperature heat sources can be exploited such as solar energy, geothermal energy and waste heat recovery from many different processes. During the design phase of an ORC system, the selection of the working fluid must be conducted in parallel with the selection and the sizing of the components (mainly the expansion machine, the pump and the heat exchangers) and with the definition of the cycle architecture. This approach allows taking into consideration all technical constraints. Relevant properties of working fluids that should be considered during their selection are listed. Major characteristics of available displacement and turbo-expander technologies are described. The impact of the pump performance on the overall performance is discussed and strategies to increase the available NPSH are proposed. Finally, improved cycle architectures are introduced. Major applications of ORC systems are described: geothermal power plants, biomass CHP plants, waste heat recovery in industry, waste heat recovery on internal combustion engines and solar power plants. All these applications differ by the nature of the heat source and heat sink, the integration of the ORC with these sources and sinks, and the range of installed capacities. These differences yield specific designs, which are described. Performance achieved by systems in operation or prototypes are presented. [less ▲]

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See detailEnjeux politiques et critiques d'une philosophie des normes
Caeymaex, Florence ULg; Pieron, Julien ULg

in Dissensus (in press), 6(printemps 2014),

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See detailIdentité territoriale et schizophrénie
Englebert, Jérôme ULg

in Gauthier, Jean-Marie; Weber, Yves; Vermeylen, Françoise (Eds.) et al Le corps partagé (in press)

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See detailCardiac concerns associated with strontium ranelate.
Reginster, Jean-Yves ULg

in Expert opinion on drug safety (in press)

Introduction: Strontium ranelate is proven to reduce vertebral and non-vertebral fracture risk in osteoporosis. Concerns about cardiac safety have led to a new contraindication to strontium ranelate in ... [more ▼]

Introduction: Strontium ranelate is proven to reduce vertebral and non-vertebral fracture risk in osteoporosis. Concerns about cardiac safety have led to a new contraindication to strontium ranelate in patients with uncontrolled hypertension and/or current or past history of ischaemic heart disease, peripheral arterial disease and/or cerebrovascular disease. Areas covered: A literature search was performed; data were also collected from the European Medicines Agency website. Randomised controlled trial (RCT) data indicate a higher incidence of non-adjudicated myocardial infarction (MI) with strontium ranelate versus placebo (1.7 vs 1.1%; odds ratio [OR]: 1.6; 95% CI: 1.07 - 2.38; p = 0.020) (Mantel-Haenzel estimate of the OR). There was no increase in cardiovascular mortality. MI risk was mitigated by excluding patients with cardiovascular contraindications (OR: 0.99; 95% CI: 0.48 - 2.04; p = 0.988). Three observational studies performed in the context of real-life medical practice in the UK and Denmark did not report a signal. Expert opinion: The increased risk for cardiac events with strontium ranelate has been detected in RCTs but not in real life. Excluding patients with cardiovascular contraindications appears to be an effective measure for controlling the risk of MI. Strontium ranelate remains a useful therapeutic alternative in patients with severe osteoporosis without cardiovascular contraindications who are unable to take another osteoporosis treatment. [less ▲]

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See detailManagement of osteoporosis of the oldest old.
Rizzoli, R.; Branco, J.; Brandi, M.-L. et al

in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (in press)

This consensus article reviews the diagnosis and treatment of osteoporosis in geriatric populations. Specifically, it reviews the risk assessment and intervention thresholds, the impact of nutritional ... [more ▼]

This consensus article reviews the diagnosis and treatment of osteoporosis in geriatric populations. Specifically, it reviews the risk assessment and intervention thresholds, the impact of nutritional deficiencies, fall prevention strategies, pharmacological treatments and their safety considerations, the risks of sub-optimal treatment adherence and strategies for its improvement. INTRODUCTION: This consensus article reviews the therapeutic strategies and management options for the treatment of osteoporosis of the oldest old. This vulnerable segment (persons over 80 years of age) stands to gain substantially from effective anti-osteoporosis treatment, but the under-prescription of these treatments is frequent. METHODS: This report is the result of an ESCEO (European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis) expert working group, which explores some of the reasons for this and presents the arguments to counter these beliefs. The risk assessment of older individuals is briefly reviewed along with the differences between some intervention guidelines. The current evidence on the impact of nutritional deficiencies (i.e. calcium, protein and vitamin D) is presented, as are strategies to prevent falls. One possible reason for the under-prescription of pharmacological treatments for osteoporosis in the oldest old is the perception that anti-fracture efficacy requires long-term treatment. However, a review of the data shows convincing anti-fracture efficacy already by 12 months. RESULTS: The safety profiles of these pharmacological agents are generally satisfactory in this patient segment provided a few precautions are followed. CONCLUSION: These patients should be considered for particular consultation/follow-up procedures in the effort to convince on the benefits of treatment and to allay fears of adverse drug reactions, since poor adherence is a major problem for the success of a strategy for osteoporosis and limits cost-effectiveness. [less ▲]

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See detailDescribing the ‘elusive’ : Availability, Preparation and Use of Anthocyanin Colourants in Mediaeval European Illuminators’ Workshops
Neven, Sylvie ULg; Sanyova, Jana

in Dubois, Hélène; Eyb-Green, Sigrid; Kroustallis, Stephanos (Eds.) et al Making and transforming art : changes in artists’ materials and practice (in press)

Anthocyanins are colorants which provide most of the blue, red and violet colours in numerous plants and fruits. Because of their great sensitivity to the slightest changes in pH and their instability in ... [more ▼]

Anthocyanins are colorants which provide most of the blue, red and violet colours in numerous plants and fruits. Because of their great sensitivity to the slightest changes in pH and their instability in ordinary daylight, it is generally thought that these colorants were used only to dye everyday clothes in a domestic context. However, medieval artists’ recipe books not only describe these elusive substances, but also indicate their use in illumination. This is notably the case for the texts of the so-called ‘Strasbourg Tradition’, written in the south of Germany and the north of France between 1400 and 1560, and partly composed from an older Alsatian treatise on illumination. Departing from these sources, this paper details the methods employed to prepare these colorants and (re)evaluates their diverse uses in painting and illuminating techniques. This technical data subsequently served as a basis upon which to make reconstructions. Finally, an attempt to correlate the information provided by these recipe books with specific artistic practices was carried out by collating the descriptions with the results of analyses from contemporary illuminations by an Alsatian workshop active in the same geographical area. [less ▲]

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See detailPSI Mehler reaction is the main alternative photosynthetic electron pathway in Symbiodinium sp., symbiotic dinoflagellates of cnidarians
Roberty, Stéphane ULg; Bailleul, Benjamin ULg; Berne, Nicolas et al

in New Phytologist (in press)

• Photosynthetic organisms have evolved various photoprotective and regulatory mechanisms to cope with changing and high light intensities. The nature and relative amplitude of these mechanisms is matter ... [more ▼]

• Photosynthetic organisms have evolved various photoprotective and regulatory mechanisms to cope with changing and high light intensities. The nature and relative amplitude of these mechanisms is matter of debate in dinoflagellates that live in symbiosis with cnidarians. In this work, the amplitude of photosynthetic alternative electron flows to oxygen (chlororespiration, Mehler reaction, mitochondrial respiration) and PSI cyclic electron flow were investigated in Symbiodinium clades A1, B1 and F1. • Cultured Symbiodinium strains were maintained semi-continuously under identical environmental conditions. Joint measurements of oxygen evolution, fluorescence emission, and absorption changes at specific wavelengths were used to evaluate PSI and PSII electron transfer rates (ETR). • A light-dependent and O2-dependent ETR was observed in all strains. This ETR involved PSII and PSI and was insensitive to addition of mitochondrial and carbon fixation inhibitors. • These results demonstrate that photoreduction of oxygen downstream of PSI by the so-called Mehler reaction is the main alternative electron sink at the onset and steady state of photosynthesis in all strains. This mechanism in Symbiodinium sustains significant levels of photosynthetic electron flux under high light, thus acting as a photoprotective mechanism and increasing the ATP/NADPH ratio by the electron transfer chain. [less ▲]

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See detailBrazil – EU Partnership: from high expectations to limited results
Santander, Sébastian ULg; Saraiva, Miriam

in European Journal of International Relations (in press)

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See detailMeteorological variation in daily travel behaviour: evidence from revealed preference data from the Netherlands
Creemers, Lieve; Wets, Geert; Cools, Mario ULg

in Theoretical & Applied Climatology (in press)

This study investigates the meteorological variation in revealed preference travel data. The main objective of this study is to investigate the impact of weather conditions on daily activity participation ... [more ▼]

This study investigates the meteorological variation in revealed preference travel data. The main objective of this study is to investigate the impact of weather conditions on daily activity participation (trip motives) and daily modal choices in the Netherlands. To this end, data from the Dutch National Travel Household Survey of 2008 were matched to hourly weather data provided by the Royal Dutch Meteorological Institute and were complemented with thermal indices to indicate the level of thermal comfort and additional variables to indicate the seasonality of the weather conditions. Two multinomial logit–generalised estimation equations (MNL-GEE) models were constructed, one to assess the impact of weather conditions on trip motives and one to assess the effect of weather conditions on modal choice. The modelling results indicate that, depending on the travel attribute of concern, other factors might play a role. Nonetheless, the thermal component, as well as the aesthetical component and the physical component of weather play a significant role. Moreover, the parameter estimates indicate significant differences in the impact of weather conditions when different time scales are considered (e.g. daily versus hourly based). The fact that snow does not play any role at all was unexpected. This finding can be explained by the relatively low occurrence of this weather type in the study area. It is important to consider the effects of weather in travel demand modelling frameworks because this will help to achieve higher accuracy and more realistic traffic forecasts. These will in turn allow policy makers to make better long-term and short-term decisions to achieve various political goals, such as progress towards a sustainable transportation system. Further research in this respect should emphasise the role of weather conditions and activityscheduling attributes. [less ▲]

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See detailTrifles for 'Unflemings'. Teaching Dutch Literary History in Nineteenth-Century Wallonia
Steyaert, Kris ULg

in Van Kalmthout, T.; Zuidervaart, H. (Eds.) The Practice of Philology in the Nineteenth-Century Netherlands (in press)

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See detailLes jugements de Dominique Lampson sur Jan Gossart et Lambert Lombard
Allart, Dominique ULg

in Delfosse, Annick; Glesener, Thomas (Eds.) Ecrire, lire et éduquer à la Renaissance, Hommage en l’honneur de Franz Bierlaire (in press)

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See detailCOMMENT JE TRAITE ... L’arrêt cardio-respiratoire extrahospitalier : la fenêtre du centraliste 112
STIPULANTE, Samuel ULg; ZANDONA, Régine; EL-FASSI, Mehdi ULg et al

in Revue Médicale de Liège (in press), 69

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See detailSophistique et Philosophie: Platon, héritier de Protagoras
Gavray, Marc-Antoine ULg

Book published by Vrin (in press)

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See detailA relaxation scheme to combine Phasor-Mode and Electromagnetic Transients Simulations
Plumier, Frédéric ULg; Aristidou, Petros ULg; Geuzaine, Christophe ULg et al

in Proceedings of the 18th Power System Computation Conference (in press)

This paper deals with a new scheme for coupling phasor-mode and electromagnetic transients simulations. In each simulation, an iteratively updated linear equivalent is used to represent the effect of the ... [more ▼]

This paper deals with a new scheme for coupling phasor-mode and electromagnetic transients simulations. In each simulation, an iteratively updated linear equivalent is used to represent the effect of the subsystem treated by the other simulation. Time interpolation and phasor extraction methods adapted to this scheme are presented and compared to existing methods. Finally, simulation results obtained with a 74-bus test system are reported. [less ▲]

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See detailAmour tordu de la patrie. Érotique et politique dans Pompes funèbres de Jean Genet
Denis, Benoît ULg

in Dubois, Jacques (Ed.) Érotique et politique dans la prose française du XXe-XXIe siècle (in press)

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See detailAn algorithm recommendation for the management of knee osteoarthritis in Europe and internationally: A report from a task force of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)
Bruyère, Olivier ULg; Cooper, C; Pelletier, JP et al

in Seminars in Arthritis & Rheumatism (in press)

Objectives: Existing practice guidelines for osteoarthritis (OA) analyze the evidence behind each proposed treatment but do not prioritize the interventions in a given sequence. The objective was to ... [more ▼]

Objectives: Existing practice guidelines for osteoarthritis (OA) analyze the evidence behind each proposed treatment but do not prioritize the interventions in a given sequence. The objective was to develop a treatment algorithm recommendation that is easier to interpret for the prescribing physician based on the available evidence and that is applicable in Europe and internationally. The knee was used as the model OA joint. Methods: ESCEO assembled a task force of 13 international experts (rheumatologists, clinical epidemiologists, and clinical scientists). Existing guidelines were reviewed; all interventions listed and recent evidence were retrieved using established databases. A first schematic flow chart with treatment prioritization was discussed in a 1-day meeting and shaped to the treatment algorithm. Fine-tuning occurred by electronic communication and three consultation rounds until consensus. Results: Basic principles consist of the need for a combined pharmacological and non-pharmacological treatment with a core set of initial measures, including information access/education, weight loss if overweight, and an appropriate exercise program. Four multimodal steps are then established. Step 1 consists of background therapy, either non-pharmacological (referral to a physical therapist for re-alignment treatment if needed and sequential introduction of further physical interventions initially and at any time thereafter) or pharmacological. The latter consists of chronic Symptomatic Slow-Acting Drugs for OA (e.g., prescription glucosamine sulfate and/or chondroitin sulfate) with paracetamol at-need; topical NSAIDs are added in the still symptomatic patient. Step 2 consists of the advanced pharmacological management in the persistent symptomatic patient and is centered on the use of oral COX-2 selective or non-selective NSAIDs, chosen based on concomitant risk factors, with intra-articular corticosteroids or hyaluronate for further symptom relief if insufficient. In Step 3, the last pharmacological attempts before surgery are represented by weak opioids and other central analgesics. Finally, Step 4 consists of end-stage disease management and surgery, with classical opioids as a difficult-to-manage alternative when surgery is contraindicated. Conclusions: The proposed treatment algorithm may represent a new framework for the development of future guidelines for the management of OA, more easily accessible to physicians. © 2014 The Authors. [less ▲]

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See detailMollino, Carlo
Prina, Daniela ULg

in Atkinson, Harriet; Kettley, Sarah; Edwards, Clive (Eds.) et al Encyclopedia of Design (in press)

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See detailHis cognitis vs. His cognitis rebus : ordre des constituants et bornage de l’Ablatif absolu
Longrée, Dominique ULg; Philippart de Foy, Caroline ULg; Purnelle, Gérald ULg

in Haverling, Gerd (Ed.) Proceedings of the 16th Int. Coll. on Latin Linguistics, Uppsala, 6-12 juin 2011 (in press)

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