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See detailP2X1 expressed on polymorphonuclear neutrophils and platelets is required for thrombosis in mice
Darbousset, Roxane; Delierneux, Céline ULg; Mezouar, Soraya et al

in Blood (in press)

Adenosine Triphosphate (ATP) and its metabolite, adenosine, are key regulators of polymorphonuclear neutrophils (PMNs) functions. PMNs have recently been implicated in the initiation of thrombosis. We ... [more ▼]

Adenosine Triphosphate (ATP) and its metabolite, adenosine, are key regulators of polymorphonuclear neutrophils (PMNs) functions. PMNs have recently been implicated in the initiation of thrombosis. We investigated the role of ATP and adenosine in PMN activation and recruitment at the site of endothelial injury. Following binding to the injured vessel wall, PMNs are activated and release elastase. The recruitment of PMNs and the subsequent fibrin generation and thrombus formation are strongly affected in mice deficient in the P2X1-ATP receptor and in wild-type mice treated with CGS 21680, an agonist of the A2A adenosine receptor or NF449 a P2X1 antagonist. Infusion of wild-type PMNs into P2X1-deficient mice increases fibrin generation but not thrombus formation. Restoration of thrombosis requires infusion of both platelets and PMNs from wild-type mice. In vitro, ATP activates PMNs, whereas CGS 21680 prevents their binding to activated endothelial cells. These data indicate that ATP contributes to PMN activation leading to their adhesion at the site of laser-induced endothelial injury, a necessary step leading to the generation of fibrin and subsequent platelet-dependent thrombus formation. Altogether, our study identifies previously unknown mechanisms by which ATP and adenosine are key molecules involved in thrombosis by regulating the activation state of PMNs. [less ▲]

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See detailLes mentions d'auteurs antiques dans les chansons de geste françaises
Henrard, Nadine ULg

in Haugeard, Philippe; Ribémont, Bernard (Eds.) Chanson de geste et savoirs savants (in press)

Les origines savantes ou populaires des épopées françaises médiévales ont longtemps fait débat. Il s'avère que ces textes contiennent un très grand nombre de références à des personnages issus de ... [more ▼]

Les origines savantes ou populaires des épopées françaises médiévales ont longtemps fait débat. Il s'avère que ces textes contiennent un très grand nombre de références à des personnages issus de l’Antiquité qui témoignent d’une formation scolaire chez les auteurs des chansons. Sur la base d'un examen de l'ensemble du corpus, cette étude s'intéresse plus particulièrement aux mentions explicites faites à des auteurs antiques, qu'ils soient grecs (Homère, Aristote, Platon) ou latins (Virgile, Ovide, César, Caton, Sénèque). En tenant de déterminer les traditions qui ont pu nourrir l'inspiration des auteurs des chansons de geste, elle s'emploie à définir les situations dans lesquelles les références en question apparaissent, et s’interroge sur les finalités que poursuivent les poètes à travers l’évocation des auteurs antiques, dont certains, comme César ou Virgile, sont davantage restés dans les mémoires pour des éléments réels ou imaginaires de leur vie plutôt que pour leur œuvre. [less ▲]

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See detailOn the asymptotic standard error of a class of robust estimators of ability in dichotomous item response models
Magis, David ULg

in British Journal of Mathematical & Statistical Psychology (in press)

In item response theory, the classical estimators of ability are highly sensitive to response disturbances and can return strongly biased estimates of the true underlying ability level. Robust methods ... [more ▼]

In item response theory, the classical estimators of ability are highly sensitive to response disturbances and can return strongly biased estimates of the true underlying ability level. Robust methods were introduced to lessen the impact of such aberrant responses onto the estimation process. The computation of asymptotic (i.e., large sample) standard errors (ASE) for these robust estimators, however, has not been fully considered yet. This paper focuses on a broad class of robust ability estimators, defined by an appropriate selection of the weight function and the residual measure, for which the ASE is derived from the theory of estimating equations. The maximum likelihood (ML) and the robust estimators, together with their estimated ASE, are then compared through a simulation study. It is concluded that both the estimators and their ASE perform similarly in absence of response disturbances, while the robust estimator and its estimated ASE are less biased and outperform their ML counterparts in presence of response disturbances with large impact on the item response process. [less ▲]

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See detailUrban governance adaptation in an old industrial city: Liège (Belgium)
Breuer, Christophe ULg; Halleux, Jean-Marie ULg; Teller, Jacques ULg

in Francese, Dora (Ed.) Napoli Citta Metropolitana (in press)

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See detailReduced Order Analysis of Aeroelastic Systems with Freeplay using an Augmented Modal Basis
Silva, Gustavo H. C.; Dal Ben Rossetto, Gustavo; Dimitriadis, Grigorios ULg

in Journal of Aircraft (in press)

Freeplay in aircraft control surface actuators is a common source of nonlinearity that can cause undesirable aeroelastic phenomena and, as a consequence, certification authorities place strict limits on ... [more ▼]

Freeplay in aircraft control surface actuators is a common source of nonlinearity that can cause undesirable aeroelastic phenomena and, as a consequence, certification authorities place strict limits on the size of the deadband gaps of actuators. In recent years many authors have worked on determining the effects of freeplay on the dynamic behavior of aeroelastic systems; these efforts have yielded significant improvements in the understanding of the phenomena, but have concentrated on simple models. Investigations of industry-relevant aeroelastic models of complete aircraft with freeplay in the actuators have been much rarer, the main difficulty being the selection of an appropriate modal basis that can represent the full range of possible dynamic phenomena. This work presents a novel implementation of the residual vectors approach to create consistent and numerically stable reduced order models suitable for industrial-standard aeroelastic models of aircraft. The methodology relies on the piecewise linear nature of freeplay to create a single reduction basis that represents the dynamics of the system both inside and outside the freeplay deadband gap. The method is demonstrated on an Embraer generic test bench aircraft, showing that the resulting reduced order model is efficient and effective. Nonlinear analysis is carried out using equivalent linearization as well as time integrations of the full nonlinear system. It is shown that, while equivalent linearization is an indispensable tool for a preliminary mapping of the main aeroelastic instabilities, the time integration-based nonlinear analysis is an essential complementary tool to confirm the characteristics of the system behavior. [less ▲]

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See detailLe Roman en prose de Guillaume d'Orange
Henrard, Nadine ULg

in Colombo-Timelli, Maria; Ferrari, Barbara (Eds.) Nouveau répertoire des mises en prose (in press)

Ce répertoire des mises en prose françaises des XVe et XVIe siècles résulte d'un projet collectif lancé à l'Université de Milan par Maria Colombo-Timelli et Barbara Ferrari en 2008, dont l'objectif était ... [more ▼]

Ce répertoire des mises en prose françaises des XVe et XVIe siècles résulte d'un projet collectif lancé à l'Université de Milan par Maria Colombo-Timelli et Barbara Ferrari en 2008, dont l'objectif était de mettre à jour et de compléter l'ouvrage classique de Georges Doutrepont, toujours incontournable mais vieux de 80 ans et périmé sur plusieurs points. Il est constitué de notices rédigées par les spécialistes des œuvres concernées; une première partie est consacrée aux mises en prose de romans ; la seconde tranche porte sur les proses issues de chansons de geste. Le volume papier permettra l'accès à la totalité des données, dont une partie est accessible en ligne à l'adresse http://users2.unimi.it/lavieenproses/ [less ▲]

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See detailL'intentionnalité cognitive et ses modes. Reinach critique de Brentano
Dewalque, Arnaud ULg

in Philosophie (in press)

Dans cet article, je suggère que la théorie reinachienne du jugement peut être vue comme une contribution à une théorie générale de l’intentionnalité cognitive et de ses modes. À cette fin, je focaliserai ... [more ▼]

Dans cet article, je suggère que la théorie reinachienne du jugement peut être vue comme une contribution à une théorie générale de l’intentionnalité cognitive et de ses modes. À cette fin, je focaliserai mon attention sur certaines divergences significatives entre Reinach et Brentano. Après quelques réflexions introductives (§§ 1-2), j’examinerai plus exactement les questions suivantes : quels sont les motifs théoriques qui ont conduit Reinach à s’écarter de la théorie brentanienne du jugement (§§ 3-4) ? Et que retenir de ses analyses aujourd’hui (§§ 5-6) ? [less ▲]

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See detailProcedural Law in Tax Law – Belgian Report
Richelle, Isabelle ULg

in Procedural Law in Tax Law (in press)

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See detailComparative biogeochemistry-ecosystem-human interactions on dynamic continental margins
Levin, Lisa A.; Liu, Kon-Kee; Kay-Christian, Emeis et al

in Journal of Marine Systems (in press)

The ocean’s continental margins face strong and rapid change, forced by a combination of direct human activity, anthropogenic CO2-induced climate change, and natural variability. Stimulated by discussions ... [more ▼]

The ocean’s continental margins face strong and rapid change, forced by a combination of direct human activity, anthropogenic CO2-induced climate change, and natural variability. Stimulated by discussions in Goa, India at the IMBER IMBIZO III, we (1) provide an overview of the drivers of biogeochemical variation and change on margins, (2) compare temporal trends in hydrographic and biogeochemical data across different margins (3) review ecosystem responses to these changes, (4) highlight the importance of margin time series for detecting and attributing change and (5) examine societal responses to changing margin biogeochemistry and ecosystems. We synthesize information over a wide range of margin settings in order to identify the commonalities and distinctions among continental margin ecosystems. Key drivers of biogeochemical variation include long-term climate cycles, CO2-induced warming, acidification, and deoxygenation, as well as sea level rise, eutrophication, hydrologic and water cycle alteration, changing land use, fishing, and species invasion. Ecosystem responses are complex and impact major margin services including primary production, fisheries production, nutrient cycling, shoreline protection, chemical buffering, and biodiversity. Despite regional differences, the societal consequences of these changes are unarguably large and mandate coherent actions to reduce, mitigate and adapt to multiple stressors on continental margins. [less ▲]

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See detailFondements et enjeux de la politique dans l'oeuvre de Jacques-Joseph Duguet
Vanhoorne, Frédérick ULg

in Aventurier, Gérard; McKenna, Anthony (Eds.) Jacques-Jospeh Duguet (1649-1733) : actes du colloque de Montbrison, 1er avril 2006 (in press)

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See detailExiste-t-il des phénomènes mentaux?
Dewalque, Arnaud ULg; Seron, Denis ULg

in Philosophie (in press), 124

This paper offers a critical discussion of the so-called argument from the transparency of experience. We recall of the argument against the historical background of phenomenal anti-dualism (Natorp, Wundt ... [more ▼]

This paper offers a critical discussion of the so-called argument from the transparency of experience. We recall of the argument against the historical background of phenomenal anti-dualism (Natorp, Wundt, Russell) and identify three difficulties of it. Eventually, we propose an alternative view, which we call phenomenological dualism. On the proposed view, there is a sense in which our mental states may be said to appear to us, hence there is a sense to say that there are mental phenomena. [less ▲]

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See detailComposantes métacognitives ; Définitions et outils d’évaluation
Frenkel, Stéphanie ULg

in Enfance : Psychologie, Pédagogie, Neuropsychiatrie, Sociologie (in press)

Many tools have been developed since the 1970s in order to assess metacognition and its first implementations. Over time, questionnaires, tests, interviews, observations, computer programmes, and other ... [more ▼]

Many tools have been developed since the 1970s in order to assess metacognition and its first implementations. Over time, questionnaires, tests, interviews, observations, computer programmes, and other methods have become more and more based on self-regulated learning theories. At the same time, for the last fifteen years or so, the number of students with learning difficulties linked to the way they learn seems to be increasing slowly but steadily. Therefore, it seems essential to enable these learners develop a more efficient learning behaviour. Similarly, we see that professional field workers are increasingly asking for efficient and adapted tools in this field. The purpose of this paper is twofold: it provides a review of the above-mentioned assessment tools, and it discusses them in order to contribute to the creation of new tools with a wider scope. Following an analysis of the abundant literature on the subject, two classifications were developed. Thirty-five tools were kept and categorised: first, according to a developmental perspective (preschool, primary school, secondary school and/or adult), second, according to the metacognitive component they assess (metacognitive knowledge, strategies and/or experiences). However, no existing tool covers the whole period of compulsory education. Moreover, in order to assess the learners’ metacognitive abilities fully, it is necessary to combine online and offline assessments in concrete situations. There are still some needs to be met in this regard. [less ▲]

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See detailKeys to the identification of prehension and hafting traces
Rots, Veerle ULg

in Marreiros, Juan; Gibaja, Juan; Bicho, Nuno (Eds.) Use-Wear and Residue Analysis in Archaeology (in press)

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See detailProjectiles and hafting technology
Rots, Veerle ULg

in Iovita, Radu; Sano, Katsuhiro (Eds.) Multidisciplinary Approaches to the Study of Stone Age Weaponry (in press)

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See detailTowards a more behavioral approach: the contribution of wear studies
Rots, Veerle ULg

in Shott, Michael (Ed.) Works in Stone (in press)

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See detailFranz Brentano. Vol. 2. Intentionality and Philosophy of Mind
Boccaccini, Federico ULg; Antonelli, Mauro

Book published by Routledge (in press)

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See detailFranz Brentano vol 1. Sources and Legacy
Boccaccini, Federico ULg; Antonelli, Mauro

Book published by Routledge (in press)

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See detailConcentration, Activity and Biochemical Characterization of Myeloperoxidase in Fresh and Post-thaw equine semen and their Implication on Freezability
Ponthier, Jérôme ULg; Franck, Thierry ULg; Parrilla Hernandez, Sonia ULg et al

in Reproduction in Domestic Animals (in press)

Myeloperoxidase (MPO) is a pro-oxidant enzyme associated with decreased motility in thawed equine semen. This study aimed to describe MPO concentration, activity and subunits in raw and thawed semen and ... [more ▼]

Myeloperoxidase (MPO) is a pro-oxidant enzyme associated with decreased motility in thawed equine semen. This study aimed to describe MPO concentration, activity and subunits in raw and thawed semen and to correlate these data with motilities in raw and thawed semen. Semen samples from five stallions were collected four times. Motilities were assessed in raw and thawed semen. MPO assays were performed in raw seminal plasma, raw sperm-rich pellet and thawed semen. Total and active MPO concentrations were, respectively, assayed by enzyme-linked immunosorbent assay and specific immunological extraction followed by enzymatic detection. MPO subunits present in semen were characterized by Western 3 blot. Purified active MPO was added in PBS and freezing extender to control its activity during freezing procedure. Differences between medians were determined using Kruskal– Wallis test, and correlations were determined using Spearman’s test for nonparametric data. Active MPO concentration was low in seminal plasma and thawed semen, but high in pellet (p = 0.0058), as the opposite relation was observed for total MPO concentration (p < 0.0001). In seminal plasma and post- thaw semen, inactive 86-kDa MPO precursor was mainly observed. Purified MPO activity was decreased in the extender (p = 0.0286). MPO activity in pellet was highly correlated with thawed progressive motility (r = 􏰑0.5576, p = 0.0086). Inac- tive MPO precursor and unknown low molecular weight inactive MPO precursor subunits explain low MPO activity in semen. Major MPO activity was observed in pellet, and post- thaw loss of activity is partially explained by MPO inactiva- tion in extender. Thawed semen motility was negatively correlated with MPO activity in pellet, becoming a potential freezability predictor. [less ▲]

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