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See detailEvaluation of the impact of 6-month training by whole body vibration on the risk of falls among nursing home residents, observed over a 12-month period: a single blind, randomized controlled trial.
Buckinx, Fanny ULg; Beaudart, Charlotte ULg; Maquet, Didier ULg et al

in Aging clinical and experimental research (in press)

BACKGROUND: We have previously shown that short sessions of whole body vibration (WBV) were not able to significantly improve fall risk among nursing home residents but some trends towards an improvement ... [more ▼]

BACKGROUND: We have previously shown that short sessions of whole body vibration (WBV) were not able to significantly improve fall risk among nursing home residents but some trends towards an improvement of motor capacity were observed. OBJECTIVE: The objective of the present study was to evaluate the impact of 6-month training by WBV on functional and motor abilities among nursing home residents observed over a 12-month period. METHODS: Patients were randomized into two groups: the WBV group which received three training sessions every week composed of five series of 15 s of vibration at 30 Hz intensity for a period of 6 months and a control group with normal daily life. The impact of this training on the risk of falls was assessed blindly after 6 and 12 months by the Tinetti Test, the "Timed Up and Go" test and a quantitative evaluation of a 10-s walk performed with a tri-axial accelerometer. The occurrence of falls was also observed. RESULTS: 62 elderly healthy volunteers, (47 women and 15 men, mean age 83.2 +/- 7.9 years) were included in this study. There was no significant difference between the two groups regarding the Tinetti test (p = 0.75), the "Timed Up and Go" test (p = 0.19) and the Locometrix(R) test, except for the step length, measured by dual task (p < 0.01). No significant inter-group difference in the frequency of falls was observed during the 12 months of research. A total of 42 falls were recorded during the first 6 months of experimentation: 24 falls in the treated group and 18 in the control group (p = 0.60). During the next 6 months, 19 falls occurred: 8 falls in the treated group and 11 in the control group (p = 0.52). CONCLUSION: This study failed to establish the effectiveness of low doses of WBV, under the conditions used in our study, on functional and motor abilities of institutionalized elderly patients. However, given the positive results of other studies, further investigations, with modified therapeutic protocols, seem necessary to clarify the effects of WBV in the elderly. [less ▲]

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See detailLa participation politique des chrétiens d’origine congolaise (RDC) à Bruxelles
Demart, Sarah ULg

in Mazzochetti, Jacinthe (Ed.) Présences subsahariennes en Belgique : un état des lieux (in press)

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See detailRemarques au sujet de la perméabilité dénominationnelle des Eglises congolaises (RDC) en migration
Demart, Sarah ULg

in Plaideau, Charlotte; Servais, Olivier; Hermesse, Julie (Eds.) Dynamiques contemporaines de la mouvance pentecôtiste". Une analyse croisée Amérique-Afrique-Europe (in press)

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See detailProteins in the gas phase
Meyer, Tim; Gabelica, Valérie ULg; Grubmüller, Helmut et al

in Wiley Interdisciplinary Reviews: Computational Molecular Science (in press)

Proteins are complex macromolecules that evolved over billions of years to be active in aqueous solution. Water is a key element that stabilizes their structure, and most structural studies on proteins ... [more ▼]

Proteins are complex macromolecules that evolved over billions of years to be active in aqueous solution. Water is a key element that stabilizes their structure, and most structural studies on proteins have thus been carried out in aqueous environment. However, recent experimental approaches have opened the possibility to gain structural information on proteins from gas-phase measurements. The obtained results revealed significant structural memory in proteins when transferred from water to the gas phase. However, after several years of experimental and theoretical research, the nature of the structural changes induced by vaporization, the exact characteristics of proteins in the gas phase, and the physicochemical forces stabilizing dehydrated proteins are still unclear. We will review here these issues using both experimental and theoretical sources of information. [less ▲]

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See detailOn the asymptotic standard error of a class of robust estimators of ability in dichotomous item response models
Magis, David ULg

in British Journal of Mathematical & Statistical Psychology (in press)

In item response theory, the classical estimators of ability are highly sensitive to response disturbances and can return strongly biased estimates of the true underlying ability level. Robust methods ... [more ▼]

In item response theory, the classical estimators of ability are highly sensitive to response disturbances and can return strongly biased estimates of the true underlying ability level. Robust methods were introduced to lessen the impact of such aberrant responses onto the estimation process. The computation of asymptotic (i.e., large sample) standard errors (ASE) for these robust estimators, however, has not been fully considered yet. This paper focuses on a broad class of robust ability estimators, defined by an appropriate selection of the weight function and the residual measure, for which the ASE is derived from the theory of estimating equations. The maximum likelihood (ML) and the robust estimators, together with their estimated ASE, are then compared through a simulation study. It is concluded that both the estimators and their ASE perform similarly in absence of response disturbances, while the robust estimator and its estimated ASE are less biased and outperform their ML counterparts in presence of response disturbances with large impact on the item response process. [less ▲]

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See detailProcedural Law in Tax Law – Belgian Report
Richelle, Isabelle ULg

in Procedural Law in Tax Law (in press)

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See detailLa légation des Pays-Bas en cour de Rome au temps de l’agent Laurent du Blioul (1573-1598): Une légation au cœur des réseaux de la monarchie de Philippe II
Regibeau, Julien ULg

in Actes du neuvième congrès de l'Association des Cercles francophones d'Histoire et d'Archéologie de Belgique (in press)

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See detailDie Neubegründung der Aufklärung. Zu den Begriffen der Referenz und der dreifachen Verknüpfung des Biologischen, des Sozialen und des Sujektiven bei Pierre Legendre
Seba, Jean-Renaud ULg

in Mein, Georg; Schneider, Manfred (Eds.) Die Zivilisation des Interpreten (in press)

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See detailDevelopmental defects in zebrafish for classification of EGF pathway inhibitors.
Pruvot, Benoist ULg; Curé, Yoann ULg; Djiotsa, Joachim et al

in Toxicology and Applied Pharmacology (in press)

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See detailFondements et enjeux de la politique dans l'oeuvre de Jacques-Joseph Duguet
Vanhoorne, Frédérick ULg

in Aventurier, Gérard; McKenna, Anthony (Eds.) Jacques-Jospeh Duguet (1649-1733) : actes du colloque de Montbrison, 1er avril 2006 (in press)

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See detailL'espace transitionnel winnicotien et l'_Urraum_ kantien
Seba, Jean-Renaud ULg

in Revista Natureza Humana (in press)

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See detailL'anthropologie de Kant entre finitude et finalité
Seba, Jean-Renaud ULg

in Cormann, Grégory (Ed.) La question anthropologique et la phénoménologie (in press)

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See detailEnhancing a CH-pi interaction to increase the affinity for 5-HT1A receptors
Liégeois, Jean-François ULg; Lespagnard, Marc; Meneses Salas, Elsa et al

in ACS Medicinal Chemistry Letters (in press)

An electrostatic interaction related to a favourable position of the distal phenyl ring and a phenylalanine residue in the binding pocket would explain the higher 5-HT1A affinity of a 4-phenyl-1,2,3,6 ... [more ▼]

An electrostatic interaction related to a favourable position of the distal phenyl ring and a phenylalanine residue in the binding pocket would explain the higher 5-HT1A affinity of a 4-phenyl-1,2,3,6-tetrahydropyridine (THP) analogue compared to the corresponding 4-phenylpiperazine analogue. To explore a possible reinforcement of this interaction to increase the affinity for 5-HT1A receptors, different 4-substituted-phenyl analogues were synthesized and tested. The most important increase of affinity is obtained with two electron-donating methyl groups in position 3 and 5 [less ▲]

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See detailMODEL PREDICTIVE CONTROL OF CONGESTION AND VOLTAGE PROBLEMS IN ACTIVE DISTRIBUTION NETWORKS
Soleimani Bidgoli, Hamid ULg; Glavic, Mevludin ULg; Van Cutsem, Thierry ULg

in Proc. of CIRED Workshop 2014 (in press)

This paper presents a centralized control scheme, inspired of Model Predictive Control (MPC), to manage thermal overloads and correct abnormal voltages in real-time. The control scheme is able to smoothly ... [more ▼]

This paper presents a centralized control scheme, inspired of Model Predictive Control (MPC), to manage thermal overloads and correct abnormal voltages in real-time. The control scheme is able to smoothly bring the system within the desired limits, taking into account its near-future evolution. The control method effectiveness is illustrated on a 20-kV, 32-bus network hosting four distributed generation units. [less ▲]

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See detailConcentration, Activity and Biochemical Characterization of Myeloperoxidase in Fresh and Post-thaw equine semen and their Implication on Freezability
Ponthier, Jérôme ULg; Franck, Thierry ULg; Parrilla Hernandez, Sonia ULg et al

in Reproduction in Domestic Animals (in press)

Myeloperoxidase (MPO) is a pro-oxidant enzyme associated with decreased motility in thawed equine semen. This study aimed to describe MPO concentration, activity and subunits in raw and thawed semen and ... [more ▼]

Myeloperoxidase (MPO) is a pro-oxidant enzyme associated with decreased motility in thawed equine semen. This study aimed to describe MPO concentration, activity and subunits in raw and thawed semen and to correlate these data with motilities in raw and thawed semen. Semen samples from five stallions were collected four times. Motilities were assessed in raw and thawed semen. MPO assays were performed in raw seminal plasma, raw sperm-rich pellet and thawed semen. Total and active MPO concentrations were, respectively, assayed by enzyme-linked immunosorbent assay and specific immunological extraction followed by enzymatic detection. MPO subunits present in semen were characterized by Western 3 blot. Purified active MPO was added in PBS and freezing extender to control its activity during freezing procedure. Differences between medians were determined using Kruskal– Wallis test, and correlations were determined using Spearman’s test for nonparametric data. Active MPO concentration was low in seminal plasma and thawed semen, but high in pellet (p = 0.0058), as the opposite relation was observed for total MPO concentration (p < 0.0001). In seminal plasma and post- thaw semen, inactive 86-kDa MPO precursor was mainly observed. Purified MPO activity was decreased in the extender (p = 0.0286). MPO activity in pellet was highly correlated with thawed progressive motility (r = 􏰑0.5576, p = 0.0086). Inac- tive MPO precursor and unknown low molecular weight inactive MPO precursor subunits explain low MPO activity in semen. Major MPO activity was observed in pellet, and post- thaw loss of activity is partially explained by MPO inactiva- tion in extender. Thawed semen motility was negatively correlated with MPO activity in pellet, becoming a potential freezability predictor. [less ▲]

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See detailRelaxations for multi-period optimal power flow problems with discrete decision variables
Gemine, Quentin ULg; Ernst, Damien ULg; Louveaux, Quentin ULg et al

in Proceedings of the 18th Power Systems Computation Conference (PSCC'14) (in press)

We consider a class of optimal power flow (OPF) applications where some loads offer a modulation service in exchange for an activation fee. These applications can be modeled as multi-period formulations ... [more ▼]

We consider a class of optimal power flow (OPF) applications where some loads offer a modulation service in exchange for an activation fee. These applications can be modeled as multi-period formulations of the OPF with discrete variables that define mixed-integer non-convex mathematical programs. We propose two types of relaxations to tackle these problems. One is based on a Lagrangian relaxation and the other is based on a network flow relaxation. Both relaxations are tested on several benchmarks and, although they provide a comparable dual bound, it appears that the constraints in the solutions derived from the network flow relaxation are significantly less violated. [less ▲]

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See detailUn témoignage sur les éclegmes: PSI 6.718
Marganne, Marie-Hélène ULg

in Boehm, Isabelle; Rousseau, Nathalie (Eds.) L'expressivité du lexique médical en Grèce et à Rome. Hommages à Françoise Skoda (in press)

Édité à deux reprises, le PSI 6.718 (Hermopolis, première moitié du IVe siècle de notre ère, parchemin, 5,6 x 7,7 cm) conserve les restes d'un recueil de nature géoponique, dont la troisième recette ... [more ▼]

Édité à deux reprises, le PSI 6.718 (Hermopolis, première moitié du IVe siècle de notre ère, parchemin, 5,6 x 7,7 cm) conserve les restes d'un recueil de nature géoponique, dont la troisième recette, jamais vraiment élucidée jusqu'ici, est en réalité relative à un éclegme. Après avoir réédité la recette, on s'interroge sur ce type de médicament, sur les mots grecs qui le désignent, sur son utilisation dans le monde gréco-romain, ainsi que sur son histoire. [less ▲]

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See detailRapid control of reproductive behaviour by locally synthesised oestrogens: focus on aromatase.
Cornil, Charlotte ULg; Seredynski, Aurore ULg; de Bournonville, Catherine ULg et al

in Journal of Neuroendocrinology (in press)

Oestrogens activate nucleus- and membrane-initiated signalling. Nucleus-initiated events control a wide array of physiological and behavioural responses. These effects generally take place within ... [more ▼]

Oestrogens activate nucleus- and membrane-initiated signalling. Nucleus-initiated events control a wide array of physiological and behavioural responses. These effects generally take place within relatively long periods of time (several hours to days). By contrast, membrane-initiated signalling affects a multitude of cellular functions in a much shorter timeframe (seconds to minutes). However, much less is known about their functional significance. Furthermore, the origin of the oestrogens able to trigger these acute effects is rarely examined. Finally, these two distinct types of oestrogenic actions have often been studied independently such that we do not exactly know how they cooperate to control the same response. The present review presents a synthesis of recent work carried out in our laboratory that aimed to address these issues in the context of the study of male sexual behaviour in Japanese quail, which is a considered as a suitable species for tackling these issues. The first section presents data indicating that 17b-oestradiol, or its membrane impermeable analogues, acutely enhances measures of male sexual motivation but does not affect copulatory behaviour. These effects depend on the activation of membrane-initiated events and local oestrogen production. The second part of this review discusses the regulation of brain oestrogen synthesis through post-translational modifications of the enzyme aromatase. Initially discovered in vitro, these rapid and reversible enzymatic modulations occur in vivo following variations in the social and environment context and therefore provide a mechanism of acute regulation of local oestrogen provision with a spatial and time resolution compatible with the rapid effects observed on male sexual behaviour. Finally, we discuss how these distinct modes of oestrogenic action (membrane- versus nucleus-initiated) acting in different time frames (short- versus long-term) interact to control different components (motivation versus performance) of the same behavioural response and improve reproductive fitness. [less ▲]

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