References of "2012"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailComment j'explore une atteinte des nerfs crâniens ?
WANG, François-Charles ULg; LOZZA, Alessandro

Conference (2012)

Detailed reference viewed: 24 (8 ULg)
Full Text
Peer Reviewed
See detailHeart rate and use of beta-blockers in stable outpatients with coronary artery disease.
Steg, Ph Gabriel; Ferrari, Roberto; Ford, Ian et al

in PLoS ONE (2012), 7(5), 36284

BACKGROUND: Heart rate (HR) is an emerging risk factor in coronary artery disease (CAD). However, there is little contemporary data regarding HR and the use of HR-lowering medications, particularly beta ... [more ▼]

BACKGROUND: Heart rate (HR) is an emerging risk factor in coronary artery disease (CAD). However, there is little contemporary data regarding HR and the use of HR-lowering medications, particularly beta-blockers, among patients with stable CAD in routine clinical practice. The goal of the present analysis was to describe HR in such patients, overall and in relation to beta-blocker use, and to describe the determinants of HR. METHODS AND FINDINGS: CLARIFY is an international, prospective, observational, longitudinal registry of outpatients with stable CAD, defined as prior myocardial infarction or revascularization procedure, evidence of coronary stenosis of >50%, or chest pain associated with proven myocardial ischemia. A total of 33,438 patients from 45 countries in Europe, the Americas, Africa, Middle East, and Asia/Pacific were enrolled between November 2009 and July 2010. Most of the 33,177 patients included in this analysis were men (77.5%). Mean (SD) age was 64.2 (10.5) years, HR by pulse was 68.3 (10.6) bpm, and by electrocardiogram was 67.2 (11.4) bpm. Overall, 44.0% had HR >/= 70 bpm. Beta-blockers were used in 75.1% of patients and another 14.4% had intolerance or contraindications to beta-blocker therapy. Among 24,910 patients on beta-blockers, 41.1% had HR >/= 70 bpm. HR >/= 70 bpm was independently associated with higher prevalence and severity of angina, more frequent evidence of myocardial ischemia, and lack of use of HR-lowering agents. CONCLUSIONS: Despite a high rate of use of beta-blockers, stable CAD patients often have resting HR >/= 70 bpm, which was associated with an overall worse health status, more frequent angina and ischemia. Further HR lowering is possible in many patients with CAD. Whether it will improve symptoms and outcomes is being tested. [less ▲]

Detailed reference viewed: 8 (0 ULg)
Full Text
Peer Reviewed
See detailToll- and NOD-like receptor mRNA expression in canine sino-nasal aspergillosis and idiopathic lymphoplasmacytic rhinitis
Mercier, Elise ULg; Peters, Iain; Clercx, Cécile ULg et al

in Veterinary Immunology and Immunopathology (2012), 145(3-4), 618-624

The pathogenesis of canine sino-nasal aspergillosis (SNA) and lymphoplasmacytic rhinitis (LPR) remains poorly understood. The innate immune system is implicated in the etiology of human chronic ... [more ▼]

The pathogenesis of canine sino-nasal aspergillosis (SNA) and lymphoplasmacytic rhinitis (LPR) remains poorly understood. The innate immune system is implicated in the etiology of human chronic rhinosinusitis. Therefore, we hypothesized that dysfunction in innate immunity could be implicated in the pathogenesis of SNA and LPR. Expression of messenger RNA (mRNA) encoding Toll-like receptors (TLRs) 1 to 10 and NOD-like receptors (NODs) 1 and 2 in nasal mucosal biopsies from SNA or LPR dogs was compared with mucosa from healthy controls. Gene expression was quantified using quantitative real-time reverse transcriptase polymerase chain reaction normalized against multiple housekeeper genes. All TLR and NOD genes were quantified in all samples. SNA was associated with significantly increased expression of TLRs 1, 2, 3, 4, 6, 7, 8, 9 and 10; and NOD2, relative to controls. LPR was associated with significantly increased expression of TLRs 1, 2, 6, 7 and 8, relative to controls. There was significantly more expression of TLRs 1, 4, 6, 7, 8, 9, 10 and NOD2 in SNA dogs than in LPR dogs. The significance of these differences in the pathogenesis of these diseases is yet to be determined. [less ▲]

Detailed reference viewed: 33 (15 ULg)
Full Text
Peer Reviewed
See detailSb2Te3 and Bi2Te3 Thin Films Grown by Room-Temperature MBE
Aabdin, Z.; Peranio, N.; Winkler, M. et al

in Journal of Electronic Materials (2012), 41(6), 1493-1497

Sb2Te3 and Bi2Te3 thin films were grown on SiO2 and BaF2 substrates at room temperature using molecular beam epitaxy. Metallic layers with thicknesses of 0.2 nm were alternately deposited at room ... [more ▼]

Sb2Te3 and Bi2Te3 thin films were grown on SiO2 and BaF2 substrates at room temperature using molecular beam epitaxy. Metallic layers with thicknesses of 0.2 nm were alternately deposited at room temperature and the films were subsequently annealed at 250A degrees C for 2 h. x-Ray diffraction and energy-filtered transmission electron microscopy (TEM) combined with high-accuracy energy-dispersive x-ray spectrometry revealed stoichiometric films, grain sizes of less than 500 nm, and a texture. High-quality in-plane thermoelectric properties were obtained for Sb2Te3 films at room temperature, i.e., low charge carrier density (2.6 x 10(19) cm(-3)), large thermopower (130 V K-1), large charge carrier mobility (402 cm(2) V-1 s(-1)), and resulting large power factor (29 W cm(-1) K-2). Bi2Te3 films also showed low charge carrier density (2.7 x 10(19) cm(-3)), moderate thermopower (-153 V K-1), but very low charge carrier mobility (80 cm(2) V-1 s(-1)), yielding low power factor (8 W cm(-1) K-2). The low mobilities were attributed to Bi-rich grain boundary phases identified by analytical energy-filtered TEM. [less ▲]

Detailed reference viewed: 22 (0 ULg)
Full Text
Peer Reviewed
See detailRecommandations 2012 en diabetologie Prise en charge de l’hyperglycémie dans le diabète de type 2 : une approche centrée sur le patient
SCHEEN, André ULg; Mathieu, Chantal

in Revue Médicale de Liège (2012), 67(12), 623-631

The pharmacological therapy of type 2 diabetes has become increasingly complex and the goals are now more diverse and, in general, more stringent. The glycaemic target (glycated haemoglobin or HbA1c ) and ... [more ▼]

The pharmacological therapy of type 2 diabetes has become increasingly complex and the goals are now more diverse and, in general, more stringent. The glycaemic target (glycated haemoglobin or HbA1c ) and the medications to be prescribed to reach it should be selected according to the individual characteristics of the patient and, if possible, in agreement with him/her. The most relevant criteria to be taken into account are the glucose-lowering efficacy, the risk of hypoglycaemia, the effect on body weight, the side effects and the costs. We summarize here the strategy proposed in the joint «position statement» published in 2012 by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). We will more particularly focus our attention on the practical aspects useful for the clinician [less ▲]

Detailed reference viewed: 57 (9 ULg)
Full Text
Peer Reviewed
See detailInteractions of the antifungal mycosubtilin with ergosterol-containing interfacial monolayers
Nasir, Mehmet Nail ULg; Besson, Françoise

in Biochimica et Biophysica Acta - Biomembranes (2012), 1818(5), 1302-1318

Mycosubtilin, an antimicrobial lipopeptide produced by Bacillus subtilis, is characterized by strong antifungal activities. The molecular mechanisms of its biological activities on the membranes of the ... [more ▼]

Mycosubtilin, an antimicrobial lipopeptide produced by Bacillus subtilis, is characterized by strong antifungal activities. The molecular mechanisms of its biological activities on the membranes of the sensitive yeasts or fungi have not yet been clearly elucidated. Our purpose was to mimic the mycosubtilin interactions with these membranes using various Langmuir monolayers. Since the major sterol of yeasts or fungi is ergosterol, the interactions of mycosubtilin with monolayers constituted by ergosterol, DPPC/ergosterol or DPPC/sphingomyelin/ergosterol were examined at different initial surface pressures (Πi). Plotting the mycosubtilin-induced surface pressure increases versus Πi allowed to determine that the exclusion pressures of mycosubtilin from these different monolayers is higher than the surface prevailing within the biological membranes. However, this behavior was lost when mycosubtilin was interacting with ergosteryl acetate-containing monolayers. This suggests the involvement of the sterol alcohol group in the mycosubtilin interactions within membranes. Furthermore, the behavior of mycosubtilin with stigmasterol, similar to that observed with ergosterol, differs from that previously observed with cholesterol, suggesting a role of the alkyl side chain of the sterols. The adsorption of mycosubtilin to ergosterol monolayers induced changes in the lipopeptide orientation at the air-water interface as revealed by polarization modulation infrared reflection absorption spectroscopy (PM-IRRAS). Moreover, imaging the air-water interface by Brewster angle microscopy (BAM) indicates that mycosubtilin induced changes in the organization and morphology of monolayers containing pure ergosterol with the appearance of small condensed dots, suggesting again that the target of mycosubtilin might be the ergosterol present in the membranes of the sensitive yeasts or fungi. [less ▲]

Detailed reference viewed: 20 (4 ULg)
Full Text
Peer Reviewed
See detailSmouldering malignant melanoma and metastatic dormancy: an update and review.
PIERARD, Gérald ULg; PIERARD-FRANCHIMONT, Claudine ULg; REGINSTER, Marie-Annick ULg et al

in Dermatology Research and Practice (2012), 2012

The fund of knowledge regarding the versatility of presentation of MM metastases is still quite incomplete. The recent literature pertaining to the current understanding of the mechanisms underlying two ... [more ▼]

The fund of knowledge regarding the versatility of presentation of MM metastases is still quite incomplete. The recent literature pertaining to the current understanding of the mechanisms underlying two special features of MM metastasis is reviewed. On the one hand, a long disease-free interval (MM dormancy) may occur before the surge of overt metastases. On the other hand, the so-called MM smouldering phenomenon refers to the condition where regional metastases wax and wane for long periods of time on restricted skin regions. It is important to emphasize that local micrometastases often predict sentinel lymph node involvement but may not reflect progression of the primary MM to full-blown visceral metastatic competence. It is likely that a combination of factors impacts the versatile MM metastasic progression. Among the main factors, one has to mention the phenotypic heterogeneity and variability in the phenotype of MM cells, the presence of MM stem cells and MM cells engaged in an amplification proliferation pool, as well as the host immune response, and possibly the induction of a particular stromal structure and vascularity. [less ▲]

Detailed reference viewed: 19 (5 ULg)
Full Text
See detailMultiple Migrations, Displacements and Land Transfers at Ta Kream in Northwest Cambodia
Pilgrim, John; Ngin, Chanrith; Diepart, Jean-Christophe ULg

in Hecht, Susanna; Kandel, Susan; Morales, Abelardo (Eds.) Migration, Rural Livelihoods and Natural Resource Management (2012)

The Cambodian case examines migration, land tenure and land management, in a context of conflict and the use of force in land transfers since the time of the Khmer Rouge regime to the present, by studying ... [more ▼]

The Cambodian case examines migration, land tenure and land management, in a context of conflict and the use of force in land transfers since the time of the Khmer Rouge regime to the present, by studying five agro-ecological zones close to the Kamping Pouy irrigation system in Battambang Province. The study combines analysis of demographic and socioeconomic characteristics of household use of land and labor with a historical and ethnographic review of conflict and institutional factors in successive land administrations. Continuing in-migration is reflected in population increases in Battambang and other provinces of Northwest Cambodia in conditions of limited land availability and landlordism, and conflict over expropriation of land by armed groups and business interests. Land transfers to a growing wealthy class of businessmen and government officials have contributed to the creation of a subclass of very poor, landless households whose livelihoods depend on agricultural wage labor, locally and in Thailand, and access to the commons. Access to land for a substantial proportion of the community depends on either tenancy, sharecropping or wage labor on the land of wealthier farmers. Three problematic processes that run counter to the Cambodian Constitution and Land Law are systemic: 1) the usurpation of land rights by locally operating armed groups; 2) legitimation of such land acquisition by military-business-government officials by corrupt officeholders and local government officials; and 3) the capture of rents or profits by agencies responsible for safeguarding natural resources. [less ▲]

Detailed reference viewed: 67 (0 ULg)
See detailEtude de l'implication de cellulases dans la synthèse de cellulose bactérienne
Delsaute, Maud ULg

Scientific conference (2012)

Detailed reference viewed: 20 (10 ULg)
Full Text
Peer Reviewed
See detailSweaty skin, background and assessments.
Noel, Fanchon; Franchimont, Claudine ULg; PIERARD, Gérald ULg et al

in International Journal of Dermatology (2012), 51(6), 647-55

Overproduction of sweat, sweaty skin, and body malodors are felt unpleasant by many people in diverse social groups. This review summarizes the functional aspects of the eccrine, apocrine, and apoeccrine ... [more ▼]

Overproduction of sweat, sweaty skin, and body malodors are felt unpleasant by many people in diverse social groups. This review summarizes the functional aspects of the eccrine, apocrine, and apoeccrine sweat glands as encountered in health and disease. A series of measuring methods are conveniently used to explore any trouble in sweat production. These include the gravimetric method, water evaporation quantification, skin staining procedures, dye injections, casting replicas, average electrometric assessments, and skin capacitance mapping / imaging (SCM). Qualitative assessment is provided by collection of sweat and volatile compounds followed by chromatographic analysis. At present, SCM appears to be the most valuable method for assessing the number of active glands and their individual sweat production by the eccrine and apoeccrine glands. [less ▲]

Detailed reference viewed: 28 (3 ULg)
Full Text
Peer Reviewed
See detailPh Ib/II study of BKM120 plus trastuzumab in patients with trastuzumab-resistant HER2+ advanced breast cancer
Pistilli, Barbara; Urruticoechea, Ander; Chan Stephen et al

in Annals of Oncology (2012), 23(supplément 9), 116

Detailed reference viewed: 42 (7 ULg)
Full Text
Peer Reviewed
See detailIschemic mitral regurgitation: Not only a bystander
Unger, P.; Magne, Julien ULg; Dedobbeleer, C. et al

in Current Cardiology Reports (2012), 14(2), 180-189

Detailed reference viewed: 19 (0 ULg)
Peer Reviewed
See detailExercise testing in aortic stenosis and in mitral regurgitation
LANCELLOTTI, Patrizio ULg; Magne, Julien ULg

in Cardiac valvular medicine (2012)

Detailed reference viewed: 20 (5 ULg)
Full Text
See detailLANDSAFE: LANDING SITE RISK ANALYSIS SOFTWARE FRAMEWORK
Schmidt, Ralph; Bostelmann, Jonas; Cornet, Yves ULg et al

in International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences (2012), XXXIX(B4), 505-510

The European Space Agency (ESA) is planning a Lunar Lander mission in the 2018 timeframe that will demonstrate precise soft landing at the polar regions of the Moon. To ensure a safe and successful ... [more ▼]

The European Space Agency (ESA) is planning a Lunar Lander mission in the 2018 timeframe that will demonstrate precise soft landing at the polar regions of the Moon. To ensure a safe and successful landing a careful risk analysis has to be carried out. This is comprised of identifying favorable target areas and evaluating the surface conditions in these areas. Features like craters, boulders, steep slopes, rough surfaces and shadow areas have to be identified in order to assess the risk associated to a landing site in terms of a successful touchdown and subsequent surface operation of the lander. In addition, global illumination conditions at the landing site have to be simulated and analyzed. The Landing Site Risk Analysis software framework (LandSAfe) is a system for the analysis, selection and certification of safe landing sites on the lunar surface. LandSAfe generates several data products including high resolution digital terrain models (DTMs), hazard maps, illumination maps, temperature maps and surface reflectance maps which assist the user in evaluating potential landing site candidates. This paper presents the LandSAfe system and describes the methods and products of the different modules. For one candidate landing site on the rim of Shackleton crater at the south pole of the Moon a high resolution DTM is showcased. * Corresponding [less ▲]

Detailed reference viewed: 55 (8 ULg)
Full Text
Peer Reviewed
See detailImpairment of assets (IAS 36), a consistent application, to what extent?
Yammine, Mira ULg

Conference (2012)

The objective of this paper is to determine whether the application of impairment of assets -IAS 36- is consistent among companies and countries. The study covers 302 companies in 16 countries which ... [more ▼]

The objective of this paper is to determine whether the application of impairment of assets -IAS 36- is consistent among companies and countries. The study covers 302 companies in 16 countries which mandate the application of IFRS for listed and consolidated companies. A descriptive analysis was performed on information obtained from financial statements for the reporting year 2008. This same information was used for linear and logistic regressions that were conducted on a number of variables that are determined from the literature to have an impact on the impairment recognition and magnitude. Some of these variables such as return, market to book ratio and leverage were found to have an impact on the impairment decision and magnitude. The impact of these variables was different whether we consider all countries pooled together or whether we put European and Non-European countries in separate groups. If we go further and treat each country individually, when enough companies are available, we notice that the impact of these variables still is different. In addition, the study showed differences in percentage of non-explained variables embedded in the residuals obtained from the regressions performed on individual and grouped countries. These differences are an indication of the presence of factors that affect the consistent application of IFRS. Some of these factors are difference in interpretation, influence of domestic accounting standards, culture and enforcement bodies. [less ▲]

Detailed reference viewed: 8 (1 ULg)
Peer Reviewed
See detailLa Domus dei Bucrani e il sistema decorativo dell’oecus dei Nani
Morard, Thomas ULg; Girard, Thibault

in Bocherens, Christophe (Ed.) Nani in Festa. Iconografia, religione e politica a Ostia durante il secondo triumvirato (2012)

Detailed reference viewed: 36 (0 ULg)
Full Text
Peer Reviewed
See detailA panel of biological tests reveals developmental effects of pharmaceutical pollutants on late stage zebrafish embryos.
Pruvot, Benoist ULg; Quiroz O' Donova, Yobhana ULg; Voncken, Audrey ULg et al

in Reproductive Toxicology (2012)

Standard toxicological assays using the zebrafish model system evaluate lethality and teratogenicity upon exposure during the first two days after fertilization. We tested the biological effects of ... [more ▼]

Standard toxicological assays using the zebrafish model system evaluate lethality and teratogenicity upon exposure during the first two days after fertilization. We tested the biological effects of several widely used drugs on zebrafish by acute treatment for 24hours starting at late embryonic stages, between 48 and 72hours post-fertilization. For 4 out of 6 compounds, we observed a higher sensitivity of late stage zebrafish embryos for general toxicity (lethality) compared to younger embryos. Morphological defects such as edema, body curvature, delayed growth, decreased heart rate and locomotion were observed for each of the compounds tested, often at sublethal concentrations. Gene expression studies on a set of four selected genes revealed a specific regulatory pattern for the different compounds tested. Our results allow us to compare various toxicological endpoints and may contribute to the design of a rational high throughput approach using the zebrafish model. [less ▲]

Detailed reference viewed: 83 (54 ULg)