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See detailBone sialoprotein: a key mediator of the angiogenic activity of hypertrophic osteoarthritic chondrocytes
Pesesse, Laurence ULg; Sanchez, Christelle ULg; Baudouin, Caroline et al

in Osteoarthritis and Cartilage (2012), 20(S), 122-123

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See detailCultivars, culture conditions and harvest time influence phenolic and ascorbic acid contents and antioxidant capacity of strawberry (Fragaria x ananassa)
Pincemail, Joël ULg; Kevers, Claire ULg; Tabart, Jessica ULg et al

in Journal of Food Science (2012), 77

Strawberries are a good source of micronutrients, especially antioxidant phenolics. More information is needed to better exploit the health-promoting effect of such fruits. Several studies focused on the ... [more ▼]

Strawberries are a good source of micronutrients, especially antioxidant phenolics. More information is needed to better exploit the health-promoting effect of such fruits. Several studies focused on the effects of genotype, cultural practices and seasonal variation on the antioxidant potential of strawberries, but often yielding contradictory results and/or focusing on only one source of variability. In the present study, we showed that total phenolic compounds, ascorbic acid and antioxidant capacity strongly differed between genotypes of strawberry. The precise results revealed the importance of genetic background for the antioxidant capacity and for the content of total phenolics (with up to 3.3-fold variations). Other parameters may also influence the antioxidant capacity in strawberry such as harvest time, culture conditions and environmental factors. Moreover, in this study, the harvesting time (at the same ripening stage) appeared to be very important, more important than genotype. Variations of the antioxidant capacity of up to 4.1-folds were observed following the harvesting time of “Elsanta” cultivar. [less ▲]

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See detailLinear magnetoelectric effect by orbital magnetism
Scaramucci, A.; Bousquet, Eric ULg; Fechner, M. et al

in Physical Review Letters (2012), 109(19),

We use symmetry analysis and first-principles calculations to show that the linear magnetoelectric effect can originate from the response of orbital magnetic moments to the polar distortions induced by an ... [more ▼]

We use symmetry analysis and first-principles calculations to show that the linear magnetoelectric effect can originate from the response of orbital magnetic moments to the polar distortions induced by an applied electric field. Using LiFePO 4 as a model compound we show that spin-orbit coupling partially lifts the quenching of the 3d orbitals and causes small orbital magnetic moments (μ (L)≈0.3μ B) parallel to the spins of the Fe2 + ions. An applied electric field E modifies the size of these orbital magnetic moments inducing a net magnetization linear in E. © 2012 American Physical Society. [less ▲]

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See detailBioindicator of Genotoxicity: the Allium cepa test
Tedesco, S; Laughinghouse IV, Haywood ULg

in Srivastava, J.K. (Ed.) Environmental Contamination (2012)

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See detailThe c-jun N-terminal Kinase (JNK)-binding Protein (JNKBP1) Acts as a Negative Regulator of NOD2 Protein Signaling by Inhibiting Its Oligomerization Process
Lecat, Aurore ULg; Di Valentin, Emmanuel ULg; Somja, Joan ULg et al

in Journal of Biological Chemistry (2012), 287(35), 29213-26

NOD2 is one of the best characterized member of the cytosolic NOD-like receptors (NLR) family. NOD2 is able to sense muramyl dipeptide (MDP), a specific bacterial cell wall component, and to subsequently ... [more ▼]

NOD2 is one of the best characterized member of the cytosolic NOD-like receptors (NLR) family. NOD2 is able to sense muramyl dipeptide (MDP), a specific bacterial cell wall component, and to subsequently induce various signalling pathways leading to NF- kappaB activation and autophagy, both events contributing to an efficient innate and adaptative immune response. Interestingly, loss-of-function nod2 variants were associated with a higher susceptibility for Crohn ' s disease (CD), which highlights the physiological importance of proper regulation of NOD2 activity. We performed a biochemical screen to search for new NOD2 regulators. We identified a new NOD2 partner, c-jun N-terminal kinase binding protein 1 (JNKBP1), a scaffold protein characterized by a N-terminal WD-40 domain. JNKBP1, through its WD-40 domain, binds to NOD2 following MDP activation. This interaction attenuates NOD2-mediated NF-kappaB activation and IL-8 secretion as well as NOD2 antibacterial activity. JNKBP1 exerts its repressor effect by disturbing NOD2 oligomerization and RIP2 tyrosine phosphorylation, both steps required for downstream NOD2 signalling. We furthermore showed that JNKBP1 and NOD2 are co-expressed in the human intestinal epithelium and immune cells recruited in the lamina propria, which suggests that JNKBP1 contributes to maintain NOD2-mediated intestinal immune homeostasis. [less ▲]

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See detailInternationaal privaatrecht geannoteerd
Wautelet, Patrick ULg; Kruger, Thalia; Verhellen, Jinske et al

Book published by La Charte (2012)

This collection presents the most important statutory materials useful for the practice in Belgium of private international law. Each instrument (Belgian Acts, European Regulations and International ... [more ▼]

This collection presents the most important statutory materials useful for the practice in Belgium of private international law. Each instrument (Belgian Acts, European Regulations and International Conventions in force in Belgium) is reproduced together with comments highlighting the most important case law in relation to the provisions studied. [less ▲]

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See detailDepicting the Missing: Prospective and Retrospective Person Memory for Age Progressed Photographs
Lampinen, James Michael; Miller, Justin T; Dehon, Hedwige ULg

in Applied Cognitive Psychology (2012), 26(2), 197-173

One approach that has been used to help recover missing children is forensic age progression. In forensic age progression, outdated photographs of missing children are aged to provide an estimate of the ... [more ▼]

One approach that has been used to help recover missing children is forensic age progression. In forensic age progression, outdated photographs of missing children are aged to provide an estimate of the current appearance of the child. We examined the effectiveness of age progressed image in the context of both prospective person memory and retrospective person memory. Memory for outdated pictures and age progressed pictures did not significantly differ. The results failed to demonstrate an advantage for age progressed pictures. [less ▲]

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See detailThe sheepshead minnow Cyprinodon variegatus as a marine vertebrate model for investigating endocrine disrupting effects of triclosan
Schnitzler, Joseph ULg; Gauthray, Ghislain ULg; Silvestre, Frédéric et al

Poster (2012)

Zebrafish (Danio rerio) has been a prominent model in toxicology. This freshwater species present many advantages both in identifying endpoints of toxicity and in elucidating mechanisms of toxicity ... [more ▼]

Zebrafish (Danio rerio) has been a prominent model in toxicology. This freshwater species present many advantages both in identifying endpoints of toxicity and in elucidating mechanisms of toxicity. However, marine toxicologists lack such omnipotent model displaying similar advantages to zebrafish: small size, rapid breeding, and easy maintenance. We propose here the use of the sheepshead minnow Cyprinodon variegatus to define thyroid-disrupting effects of triclosan during pre-hatching development. Three females and two males were placed in each of the three breeding chambers designed for this experiment. More than 300 eggs were collected over three days and maintained in seawater with triclosan concentrations at 0, 100 ng.L-1, and 100 µg.L-1. Exposure of larvae to triclosan lasted until hatching. After hatching (six days post-spawning), 5 larvae per condition were placed in Bouin’s fixative for brain and thyroid histology. Length and body mass were measured. The body was frozen at -80oC to determine muscle thyroid hormone levels (T3 and T4), using radio-immunoassay techniques. Hatching success, in vivo observations, gross observation, thyroid hormone levels, histology will be determined and discussed in the framework of whether or not triclosan may alter thyroid metabolism during pre-hatching period of the sheepshead minnow. [less ▲]

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See detailDiversité du répertoire acoustique des poissons clowns
Colleye, Orphal ULg; Parmentier, Eric ULg

Conference (2012)

Les poissons clowns (Amphiprion spp.) appartiennent à la famille des Pomacentridae. Ces poissons sont bien connus pour leur relation de mutualisme avec les anémones de mer. Au sein de leur hôte, ils ... [more ▼]

Les poissons clowns (Amphiprion spp.) appartiennent à la famille des Pomacentridae. Ces poissons sont bien connus pour leur relation de mutualisme avec les anémones de mer. Au sein de leur hôte, ils vivent en groupe composé d’un nombre variable d’individus selon les espèces. Chaque groupe est hiérarchisée sur la base de la taille des individus : la femelle est l’individu le plus grand et dominant, elle est accompagnée d’un mâle reproducteur, lui même suivi des autres individus sexuellement immatures toujours ordonnés selon leur taille. Cette structure sociale implique le respect de la hiérarchie et de la territorialité. Les interactions agonistiques jouent un rôle important car elles permettent de maintenir des différences de tailles entre les individus de rang adjacent pour éviter les conflits incessants entre individus dominants et subordonnés. Des comportements d’agression sont donc réalisés de la part de chaque dominant envers le ou les subordonnés de rangs inférieurs. En réponse à ces comportements d’agression, les individus subordonnés adoptent des postures d’apaisement envers le ou les dominants de rang supérieur. En plus de ces différents comportements agonistiques, la reproduction est très ritualisée et comporte plusieurs phases telles que la préparation du nid, les parades amoureuses, la ponte ou encore les soins prodigués aux œufs. Quelques études ont rapporté que ces différents comportements agonistiques et reproducteurs pouvaient s’accompagner d’émissions sonores. Cependant, ces études souffraient d’un manque de rigueur dans la description des sons et de leur contexte d’émission. L’intérêt de la présente étude était donc d’identifier et de décrire les sons produits dans divers contextes comportementaux afin de déterminer si différents types de sons peuvent être liés à un même comportement ou encore si un même son peut intervenir dans différents contextes. Les enregistrements de sons indiquent qu’aucun signal acoustique n’est associé aux différentes activités liées à la reproduction. Lors des interactions agonistiques, deux types de sons ont été enregistrés. Les sons d’agression sont toujours émis par un individu dominant à l’encontre d’un subordonné lors des poursuites et autres comportements de menace. A l’inverse, les sons de soumission sont émis par les subordonnés lors d’un comportement caractéristique qualifié de "head shaking". Ces deux types de sons présentent plusieurs différences dans leur allure acoustique et leurs paramètres. Les sons d’agression se composent toujours d’une pulsation qui peut être émise seule ou en série alors que les sons de soumissions sont toujours composés de plusieurs pulsations et sont généralement émis sous forme de train de plusieurs sons. Les durées des pulsations des sons d’agression sont plus longues que celles des sons de soumission. La période des pulsations est considérablement plus longue pour les sons d’agression que pour les sons de soumission, suggérant que chaque pulsation est émise comme une unité bien distincte. De plus, la durée des sons est beaucoup plus longue pour les sons d’agression que pour les sons de soumission. Ces deux types de sons agonistiques montrent également des variations intraspécifiques liées à la taille au niveau de la fréquence dominante et la durée des pulsations. Plus un poisson est grand, plus les sons qu’il émet présente des fréquences basses et des durées élevées, et inversement. Ces différences observées dans les fréquences et les durées des pulsations n’apparaissent ni liées au sexe, ni au rang social mais dépendent uniquement du dimorphisme. Au sein du groupe, les deux types de sons agonistiques semblent donc avoir des fonctions différentes : les sons d’agression pourraient avoir un rôle dissuasif en transmettant un signal de rappel du rang social, alors que les sons de soumission pourraient avoir un rôle d’apaisement en rappelant le statut social du subordonné. Par ailleurs, les fréquences dominantes et les durées des pulsations sont des signaux acoustiques qui véhiculent des informations relatives à la taille de l’individu émetteur ; ils pourraient donc jouer un rôle important dans la reconnaissance de l’individu et le maintien de la cohésion au sein du groupe. [less ▲]

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See detailA Review of Known and Hypothetical Transmission Routes for Noroviruses
Mathijs, E.; Stals, A.; Baert, L. et al

in Food and Environmental Virology (2012), 4(4), 131-152

Human noroviruses (NoVs) are considered a worldwide leading cause of acute non-bacterial gastroenteritis. Due to a combination of prolonged shedding of high virus levels in feces, virus particle shedding ... [more ▼]

Human noroviruses (NoVs) are considered a worldwide leading cause of acute non-bacterial gastroenteritis. Due to a combination of prolonged shedding of high virus levels in feces, virus particle shedding during asymptomatic infections, and a high environmental persistence, NoVs are easily transmitted pathogens. Norovirus (NoV) outbreaks have often been reported and tend to affect a lot of people. NoV is spread via feces and vomit, but this NoV spread can occur through several transmission routes. While person-to-person transmission is without a doubt the dominant transmission route, human infective NoV outbreaks are often initiated by contaminated food or water. Zoonotic transmission of NoV has been investigated, but has thus far not been demonstrated. The presented review aims to give an overview of these NoV transmission routes. Regarding NoV person-to-person transmission, the NoV GII. 4 genotype is discussed in the current review as it has been very successful for several decades but reasons for its success have only recently been suggested. Both pre-harvest and post-harvest contamination of food products can lead to NoV food borne illness. Pre-harvest contamination of food products mainly occurs via contact with polluted irrigation water in case of fresh produce or with contaminated harvesting water in case of bivalve molluscan shellfish. On the other hand, an infected food handler is considered as a major cause of post-harvest contamination of food products. Both transmission routes are reviewed by a summary of described NoV food borne outbreaks between 2000 and 2010. A third NoV transmission route occurs via water and the spread of NoV via river water, ground water, and surface water is reviewed. Finally, although zoonotic transmission remains hypothetical, a summary on the bovine and porcine NoV presence observed in animals is given and the presence of human infective NoV in animals is discussed. © 2012 Springer Science+Business Media New York. [less ▲]

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See detailIllusory recollection: The compelling subjective remembrance of things that never happened. Insights from the DRM paradigm.
Dehon, Hedwige ULg

in Psychologica Belgica (2012)

Illusory recollection is the subjective detailed feeling of remembering that sometimes accompanies false remembering of events that never happened (e.g., high confidence, “Remember” judgements, or even ... [more ▼]

Illusory recollection is the subjective detailed feeling of remembering that sometimes accompanies false remembering of events that never happened (e.g., high confidence, “Remember” judgements, or even remembrance of precise details supposedly associated with the false event). In this review, typical illusory recollection measures obtained from laboratory studies will be depicted, with a focus on the DRM paradigm (Deese, 1959; Roediger & McDermott, 1995), one of the most largely used procedures to study memory distortion and its associated illusory recollection. The theoretical explanations of illusory recollection will be described and contrasted in light of factors affecting the phenomenon, in order to shown their strengths and limits. Although the focus on the origins of illusory recollection is relatively recent, overall, this review suggests that DRM false memories can be an excellent tool to study this phenomenon under controlled conditions and to gain insights on false memories occurring in everyday life. [less ▲]

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See detailEnseigner la co-conception à distance : Retour sur cinq années d’expérience
Safin, Stéphane ULg; Kubicki, Sylvain; Hanser, Damien et al

in Guéna, François; Lecourtois, Caroline (Eds.) Complexité(s) des modèles de l'architecture numérique (2012)

Le LUCID-ULg et l’ENSA de Nancy organisent depuis cinq années le Studio Digital Collaboratif. Il s’agit d’un atelier de conception architecturale collaboratif à distance. Plusieurs groupes réunissant ... [more ▼]

Le LUCID-ULg et l’ENSA de Nancy organisent depuis cinq années le Studio Digital Collaboratif. Il s’agit d’un atelier de conception architecturale collaboratif à distance. Plusieurs groupes réunissant entre quatre et six étu- diants liégeois et nancéiens, conçoivent un projet architectural d’une certaine ampleur dans un délai de trois mois. Ce papier propose un retour sur cette ex- périence, dans ses aspects pédagogiques, organisationnels et technologiques. [less ▲]

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See detailLes concepts de territorialisation et de ritournelle pour appréhender la perte de corps commun dans la psychose
Englebert, Jérôme ULg

in Sami-Ali; Cady, Sylvie (Eds.) Psychosomatique de l'enfant, de l'adolescent et de l'adulte (2012)

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See detailThe Palaeocene/Eocene boundary section at Zumaia (Basque-Cantabric Basin) revisited: New insights from high-resolution magnetic susceptibility and carbon isotope chemostratigraphy on organic matter (δ 13C org)
Storme, Jean-Yves ULg; Devleeschouwer, X.; Schnyder, J. et al

in Terra Nova (2012), 24(4), 310-317

The Zumaia section, the most complete and representative section of the early Palaeogene (hemi)-pelagic succession of the Pyrenees, is widely acknowledged as a key reference for the Palaeocene-Eocene ... [more ▼]

The Zumaia section, the most complete and representative section of the early Palaeogene (hemi)-pelagic succession of the Pyrenees, is widely acknowledged as a key reference for the Palaeocene-Eocene boundary. New high-resolution δ 13C org of the Zumaia section (-23.8 to -28.8‰) confirms the position of the Carbon Isotope Excursion and enhances the distinction between the different steps of the CIE/PETM event. According to new magnetic susceptibility data and detailed cycle counting, the entire duration of the CIE/PETM in Zumaia is estimated in ∼168±16ka. Moreover, the investigation of palynofacies and low-field magnetic susceptibility reveal significant detrital influx during the interval. Several magnetic susceptibility phases and trends are recognised and are interpreted in terms of sea-level fluctuations before, during and after the PETM. Coupled with results from other sections, our data reveal the presence of an unconformity followed by an eustatic sea-level rise (TST) in the latest Palaeocene. © 2012 Blackwell Publishing Ltd. [less ▲]

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See detailNuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance.
Kasler, Herbert G.; Lim, Hyung W.; Mottet, Denis ULg et al

in EMBO Journal (2012)

Histone deacetylase 7 (HDAC7) is a T-cell receptor (TCR) signal-dependent regulator of differentiation that is highly expressed in CD4/CD8 double-positive (DP) thymocytes. Here, we examine the effect of ... [more ▼]

Histone deacetylase 7 (HDAC7) is a T-cell receptor (TCR) signal-dependent regulator of differentiation that is highly expressed in CD4/CD8 double-positive (DP) thymocytes. Here, we examine the effect of blocking TCR-dependent nuclear export of HDAC7 during thymic selection, through expression of a signal-resistant mutant of HDAC7 (HDAC7-DeltaP) in thymocytes. We find that HDAC7-DeltaP transgenic thymocytes exhibit a profound block in negative thymic selection, but can still undergo positive selection, resulting in the escape of autoreactive T cells into the periphery. Gene expression profiling reveals a comprehensive suppression of the negative selection-associated gene expression programme in DP thymocytes, associated with a defect in the activation of MAP kinase pathways by TCR signals. The consequence of this block in vivo is a lethal autoimmune syndrome involving the exocrine pancreas and other abdominal organs. These experiments establish a novel molecular model of autoimmunity and cast new light on the relationship between thymic selection and immune self-tolerance. [less ▲]

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See detailSpatial variability of leaf area index in homogeneous forests relates to local variation in tree characteristics
Bequet, R; Campioli, M; Kint, V et al

in Forest Science (2012), 58(6), 633-640

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See detailUstekinumab in psoriasis immunopathology with emphasis on the Th17-IL23 axis. A primer.
QUATRESOOZ, Pascale ULg; Hermanns-Lê, Trinh ULg; Pierard, Gérald ULg et al

in Journal of Biomedicine & Biotechnology (2012), 2012(147413),

Psoriasis is a chronic relapsing immunoinflammatory dermatosis that is commonly associated with systemic comorbidities. The pathogenic importance of interleukin (IL)-12 and IL-23 is beyond doubt, as well ... [more ▼]

Psoriasis is a chronic relapsing immunoinflammatory dermatosis that is commonly associated with systemic comorbidities. The pathogenic importance of interleukin (IL)-12 and IL-23 is beyond doubt, as well as the involvement of T helper cells (Th)1 and Th17 cells. There is upregulation of the p40 subunit shared by IL-12 and IL-23 and of the IL-23 p19 subunit, but not an increased expression of the IL-12 p35 subunit. This indicates that IL-23 appears more involved than IL-12 in the pathogenesis of psoriatic plaques. Ustekinumab is a fully human monoclonal antibody of the immunoglobulin (Ig) G1 class targeting the p40 subunit common to both IL-12 and IL-23, thus inhibiting both IL-12 and IL-23 receptor-mediated signalling. Ustekinumab is part of the recent biologic therapies active in psoriasis, autoimmune arthritides, and inflammatory bowel diseases. [less ▲]

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See detailUranus Pathfinder: exploring the origins and evolution of Ice Giant planets
Arridge, Christopher S.; Agnor, Craig B.; Andre, Nicolas et al

in Experimental Astronomy (2012)

The "Ice Giants" Uranus and Neptune are a different class of planet compared to Jupiter and Saturn. Studying these objects is important for furthering our understanding of the formation and evolution of ... [more ▼]

The "Ice Giants" Uranus and Neptune are a different class of planet compared to Jupiter and Saturn. Studying these objects is important for furthering our understanding of the formation and evolution of the planets, and unravelling the fundamental physical and chemical processes in the Solar System. The importance of filling these gaps in our knowledge of the Solar System is particularly acute when trying to apply our understanding to the numerous planetary systems that have been discovered around other stars. The Uranus Pathfinder (UP) mission thus represents the quintessential aspects of the objectives of the European planetary community as expressed in ESA's Cosmic Vision 2015-2025. UP was proposed to the European Space Agency's M3 call for medium-class missions in 2010 and proposed to be the first orbiter of an Ice Giant planet. As the most accessible Ice Giant within the M-class mission envelope Uranus was identified as the mission target. Although not selected for this call the UP mission concept provides a baseline framework for the exploration of Uranus with existing low-cost platforms and underlines the need to develop power sources suitable for the outer Solar System. The UP science case is based around exploring the origins, evolution, and processes at work in Ice Giant planetary systems. Three broad themes were identified: (1) Uranus as an Ice Giant, (2) An Ice Giant planetary system, and (3) An asymmetric magnetosphere. Due to the long interplanetary transfer from Earth to Uranus a significant cruise-phase science theme was also developed. The UP mission concept calls for the use of a Mars Express/Rosetta-type platform to launch on a Soyuz-Fregat in 2021 and entering into an eccentric polar orbit around Uranus in the 2036-2037 timeframe. The science payload has a strong heritage in Europe and beyond and requires no significant technology developments. [less ▲]

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