References of "2012"
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See detailImpact of medical therapies on inflammatory bowel disease complication rate.
REENAERS, Catherine ULg; Belaiche, Jacques ULg; Louis, Edouard ULg

in World Journal of Gastroenterology (2012), 18(29), 3823-7

Crohn's disease and ulcerative colitis are progressive diseases associated with a high risk of complications over time including strictures, fistulae, perianal complications, surgery, and colorectal ... [more ▼]

Crohn's disease and ulcerative colitis are progressive diseases associated with a high risk of complications over time including strictures, fistulae, perianal complications, surgery, and colorectal cancer. Changing the natural history and avoiding evolution to a disabling disease should be the main goal of treatment. In recent studies, mucosal healing has been associated with longer-term remission and fewer complications. Conventional therapies with immunosuppressive drugs are able to induce mucosal healing in a minority of cases but their impact on disease progression appears modest. Higher rates of mucosal healing can be achieved with anti-tumor necrosis factor therapies that reduce the risk of relapse, surgery and hospitalization, and are associated with perianal fistulae closure. These drugs might be able to change the natural history of the disease mainly when introduced early in the course of the disease. Treatment strategy in inflammatory bowel diseases should thus be tailored according to the risk that each patient could develop disabling disease. [less ▲]

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See detailQuand l'enfant dit "Je"
Boulard, Aurore ULg; Gauthier, Jean-Marie ULg

in Enfance : Psychologie, Pédagogie, Neuropsychiatrie, Sociologie (2012), 64(2), 233-246

L’analyse statistique d’un corpus constitué de 309 discours d’enfants a permis d’observer l’évolution de l’utilisation des pronoms personnels « moi » et « je » et de mettre en évidence certaines ... [more ▼]

L’analyse statistique d’un corpus constitué de 309 discours d’enfants a permis d’observer l’évolution de l’utilisation des pronoms personnels « moi » et « je » et de mettre en évidence certaines variations d’utilisation en fonction de l’âge (entre 3 et 10 ans) et des conditions de production discursive. [less ▲]

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See detailAnalytical evaluation of the new Abbott Architect 25-OH vitamin D assay
CAVALIER, Etienne ULg; CARLISI, Ignazia ULg; BEKAERT, Anne-Catherine ULg et al

in Clinical Biochemistry (2012), 45

Objectives: Validation of the Architect 25-OH vitamin D assay. Design and methods: Determination of repeatability, reproducibility, accuracy profile and 25(OH)-vitamin D2 recovery on native samples ... [more ▼]

Objectives: Validation of the Architect 25-OH vitamin D assay. Design and methods: Determination of repeatability, reproducibility, accuracy profile and 25(OH)-vitamin D2 recovery on native samples. Comparison with DiaSorin Liaison and RIA. Results and conclusion: Coefficients of variation: b6% (13.6 ng/mL) and 2.2% (78.1 ng/mL). Functional sensitivity: 5 ng/mL. Accuracy profile shows that the method is validated between 13.6 and 78.1 ng/mL. Recovery of 25(OH)D2: 75,8%( 95% CI: 61.9–89.7%). Good correlation with DiaSorin RIA and Liaison b50 ng/mL; above this threshold a systematic positive bias was observed. [less ▲]

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See detailBacillus subtilis: biocontrol and growth promotion
Ongena, Marc ULg

Conference (2012)

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See detailChronique de droit à l'usage des juges de paix et de police 2012
Lecocq, Pascale ULg; Dambre, Maarten

Book published by la charte (2012)

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See detailL’Atlas linguistique de la Wallonie à mi-parcours. État des lieux et perspectives
Baiwir, Esther ULg

in Bulletin de la Commission Royale de Toponymie et de Dialectologie = Handelingen van de Koninklijke Commissie voor Toponymie en Dialectologie (2012), LXXXIV

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See detailFlexibility and Applicability of β-expectation tolerance interval approach to assess the fitness of purpose of pharmaceutical analytical methods
Bouabidi, Abderrahim; Talbi, M.; Bourichi, H. et al

in Drug Testing and Analysis (2012), 4(12), 1014-1027

An innovative versatile strategy using Total Error has been proposed to decide about the method’s validity that controls the risk of accepting an unsuitable assay together with the ability to predict the ... [more ▼]

An innovative versatile strategy using Total Error has been proposed to decide about the method’s validity that controls the risk of accepting an unsuitable assay together with the ability to predict the reliability of future results. This strategy is based on the simultaneous combination of systematic (bias) and random (imprecision) error of analytical methods. Using validation standards both types of error are combined through the use of a prediction interval or β-expectation tolerance interval. Finally, an accuracy profile is built by connecting, on one hand all the upper tolerance limits, and on the other hand all the lower tolerance limits. This profile combined with pre-specified acceptance limits allows to evaluate the validity of any quantitative analytical method and thus their fitness for their intended purpose. In this work, the approach of accuracy profile was evaluated on several types of analytical methods encountered in pharmaceutical industrial field and also covering different pharmaceutical matrices. The four studied examples depicted the flexibility and applicability of this approach for different matrices ranging from tablets to syrups, different techniques such as liquid chromatography, or UV spectrophotometry and for different categories of assays commonly encountered in the pharmaceutical industry that are content assays, dissolution assays and quantitative impurity assays. The accuracy profile approach assesses the fitness of purpose of these methods for their future routine application,. It also allows to select the most suitable calibration curve, to evaluate adequately a potential matrix effect and propose efficient solution and to define correctly the limits of quantification of the studied analytical procedures. [less ▲]

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See detailLa déontologie, à la croisée de l'éthique et du droit
Genicot, Gilles ULg

in L'éthique en médecine bucco-dentaire (2012)

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See detailInfluence of forest degradation on tree diversity in a forest-savannah transition in Eastern Ivory Coast
Barima, YSS; Angaman, MD; De Cannière, C et al

in International Journal of Biological and Chemical Sciences (2012), 6(4), 1467-1497

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See detailHemocompatibility of liposomes loaded with lipophilic prodrugs of methotrexate and melphalan in the lipid bilayer
Kuznetsova, Natalia R.; Sevrin, Chantal ULg; Lespineux, David et al

in Journal of Controlled Release (2012)

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See detailEctopic Hormones-Secreting Pheochromocytoma: A Francophone Observational Study
KIRKBY-BOTT, James; BRUNAUD, Laurent; MATHONET, Muriel et al

in World Journal of Surgery (2012), 36

Background Ectopic hormone-secreting pheochromocytomas <br />are rare; only case reports exist in the literature. This <br />condition has been linked with increased malignancy, <br />familial syndromes ... [more ▼]

Background Ectopic hormone-secreting pheochromocytomas <br />are rare; only case reports exist in the literature. This <br />condition has been linked with increased malignancy, <br />familial syndromes, and ACTH secretion. We wanted to <br />test these hypotheses and shed light on the nature of ectopic <br />hormone-secreting pheochromocytomas. <br />Methods This is a multicenter (francophone) observational <br />study. Inclusion was based upon abnormal preoperative <br />hormone tests in patients with pheochromocytoma <br />that normalized after removal of the tumor. Where <br />possible, immunohistochemistry was performed to confirm <br />that ectopic secretion came from the tumor. <br />Results Sixteen cases were found: nine female and seven <br />male patients. Median age was 50.5 (range 31–89) years. <br />Most presented with hypertension, diabetes, or cushingoid <br />features. Ten patients had specific symptoms from the <br />ectopic hormone secretion. Two had a familial syndrome. <br />Of eight patients with excess cortisol secretion, three died <br />as a result of the tumor resection: two had pheochromocytomas[ <br />15 cm and their associated cortisol hypersecretion <br />complicated their postoperative course. The other died <br />from a torn subhepatic vein. The 13 survivors did not <br />develop any evidence of malignancy during follow-up <br />(median 50 months). Symptoms from the ectopic secretion <br />resolved after removal of the tumor. Immunohistochemistry <br />was performed and was positive in eight tumors: five <br />ACTH, three calcitonins, and one VIP. <br />Conclusions Most pheochromocytomas with ectopic <br />secretion are neither malignant nor familial. Most ectopic <br />hormone-secreting pheochromocytoma cause hypercortisolemia. <br />Patients with a pheochromocytoma should be <br />worked up for ectopic hormones, because removal of the <br />pheochromocytoma resolves those symptoms. Associated <br />cortisol secretion needs careful attention. [less ▲]

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See detailLa visite au zoo et l'apprentissage de la distinction humaine
Servais, Véronique ULg

in Revue d'Anthropologie des Connaissances (2012), 6(3), 157-184

The zoo might be regarded as a cultural device that structures the relationships between human beings and captive animals. In this study we searched to identify the patterns that connect visitors and ... [more ▼]

The zoo might be regarded as a cultural device that structures the relationships between human beings and captive animals. In this study we searched to identify the patterns that connect visitors and captive animals during the zoo visit experience. We recorded and analysed the speech and interactions of visitors in front of the cages of two primate species: Orangutans (Pongo pygmaeus) and braza monkeys (Cercopithecus neglectus) with the aim of understanding how the human/non human boundary is practically accomplished. [less ▲]

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See detailEinführung
Brüll, Christoph ULg

in Brüll, Christoph (Ed.) ZOOM 1920-2010. Nachbarschaften neun Jahrzehnte nach Versailles (2012)

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See detailNebulized Anti-IL-13 Monoclonal Antibody Fab' Fragment Reduces Allergen-Induced Asthma
Hacha, Jonathan ULg; Tomlinson, K; Maertens, Ludovic ULg et al

in American Journal of Respiratory Cell and Molecular Biology (2012), sous presse

Rationale: Interleukin-13 (IL-13) is a prototypic Th2 cytokine and a central mediator of the complex cascade of events leading to asthmatic phenotype. Indeed, IL-13 plays key roles in IgE synthesis ... [more ▼]

Rationale: Interleukin-13 (IL-13) is a prototypic Th2 cytokine and a central mediator of the complex cascade of events leading to asthmatic phenotype. Indeed, IL-13 plays key roles in IgE synthesis, bronchial hyperresponsiveness, mucus hypersecretion, subepithelial fibrosis and eosinophil infiltration. Objectives: We assessed the potential efficacy of inhaled anti-IL-13 monoclonal antibody Fab' fragment on allergen-induced airway inflammation, hyperresponsiveness and remodeling in an experimental model of allergic asthma. Anti-IL-13 Fab' was administered to mice as a liquid aerosol generated by inExpose® inhalation system in a tower allowing a nose-only exposure. Methods: BALB/c mice were treated by PBS, anti-IL-13 Fab' or A33 Fab' fragment and subjected to ovalbumin (OVA) exposure for 1 and 5 weeks (short term (ST) and long term (LT) protocols). Measurements and Main Results: Our data demonstrate a significant anti-asthma effect following nebulization of anti-IL-13 Fab' in a model of asthma driven by allergen exposure as compared to saline and non-immune Fab fragments. In short and long terms protocols, administration of the anti-IL-13 Fab' by inhalation significantly decreased bronchial responsiveness to methacholine, BALF eosinophilia, inflammatory cell infiltration in lung tissue, and many features of airway remodeling. Levels of pro-inflammatory mediators and matrix metalloprotease levels were significantly lower in lung parenchyma of mice treated with anti-IL-13 Fab'. Conclusions: These data demonstrate that an inhaled anti-IL-13 Fab' significantly reduces airway inflammation, hyperresponsiveness and remodeling. Specific neutralization of IL-13 in the lungs using an inhaled anti-IL-13 Fab' could represent a novel and effective therapy for the treatment of asthma. [less ▲]

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See detailLe reportage
Durand, Pascal ULg

in Kalifa, Dominique; Thérenty, Marie-Eve; Vaillant, Alain (Eds.) et al La civilisation du journal. Histoire culturelle et littéraire de la presse française au XIXe siècle (2012)

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See detailA Method to Evaluate the Energy Consumption of Suburban Neighbourhoods
Marique, Anne-Françoise ULg; Reiter, Sigrid ULg

in HVAC&R Research (2012), 18(1-2), 88-99

Energy use in buildings, transportation systems and lighting networks represents a significant contribution to the overall energy consumption in urban and suburban areas. This paper presents a method to ... [more ▼]

Energy use in buildings, transportation systems and lighting networks represents a significant contribution to the overall energy consumption in urban and suburban areas. This paper presents a method to evaluate the energy consumption of suburban neighborhoods from these three points of view, aiming to highlight the most relevant variables linking urban form and neighborhoods energy consumptions. The method includes three parts: 1) a computational approach combining dynamic simulation tools and a database of building typologies to determine the energy consumed in heating; 2) an empirical approach to assess the energy consumed by transportation systems (four purposes of travel are taking into account: work, school, leisure and shopping); and 3) a simplified approach to calculate the energy consumed by public lighting. Results from the application of the method to three characteristic suburban neighborhoods in Belgium are presented along with a life cycle energy assessment of buildings. A sensitivity analysis was conducted to determine the effects of building and neighborhood characteristics and of building inhabitant behavior on calculated energy consumption. Results from the analysis show that building insulation, building distribution, heating system management and neighborhood location are critically important factors in the energy efficiency of suburban residential areas. [less ▲]

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See detailRemoving the North Pacific halocline: effects on global climate, ocean circulation and the carbon cycle
Menviel, L.; Timmermann, A.; Timm, O. et al

in Deep-Sea Research Part II, Topical Studies in Oceanography (2012), 61-64

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See detailMesenchymal stromal cells : a new tool against graft-versus-host disease ?
Baron, Frédéric ULg; Storb, Rainer

in Biology of Blood & Marrow Transplantation (2012), 18(6), 822-840

Mesenchymal stromal cells (MSCs) represent a heterogeneous subset of multipotent cells that can be isolated from several tissues including bone marrow and fat. MSCs exhibit immunomodulatory and anti ... [more ▼]

Mesenchymal stromal cells (MSCs) represent a heterogeneous subset of multipotent cells that can be isolated from several tissues including bone marrow and fat. MSCs exhibit immunomodulatory and anti-inflammatory properties that prompted their clinical use as prevention and/or treatment for severe graft-versus-host disease (GVHD). Although a number of phase I-II studies have suggested that MSCs infusion was safe and might be effective for preventing or treating acute GVHD, definitive proof for their efficacy remains lacking thus far. Multicenter randomized studies are ongoing to more precisely assess the impact of MSCs infusion on GVHD prevention/treatment, whereas further research is performed in vitro and in animal models with the aims of determining the best way to expand MSCs ex vivo as well as the most efficient dose and schedule of MSCs administration. After introducing GVHD, MSC biology, and results of MSCs infusion in animal models of allogeneic hematopoietic cell transplantation, this article reviews the results of the first clinical trials investigating the use of MSCs infusion as prevention or treatment of GVHD. [less ▲]

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See detailPathologies of concrete in Saint-Vincent Neo-Byzantine Church and Pauchot reinforced artificial stone
Courard, Luc ULg; Gillard, Anne; Darimont, Anne ULg et al

in Construction & Building Materials (2012), 34

Reinforced concrete is a key element of the architectural evolution and has been specifically involved in the development of Catholic Church architecture, particularly during the second part of the XXth ... [more ▼]

Reinforced concrete is a key element of the architectural evolution and has been specifically involved in the development of Catholic Church architecture, particularly during the second part of the XXth century. This article focuses on the Saint-Vincent Church, Liege district, Belgium. With concrete as major building material, this was built in only 20 months, from 1928 to 1930. This monumental building, from Neo Byzantine style, however presents some degradations. A visual inspection, as well as non destructive and laboratory tests, are presented and analysed. They help to make a clear diagnosis and to assess hypothesis on the real state of this high-quality architectural building. Moreover, specific investigations have been realized on a special mortar used for wall construction: Pauchot reinforced artificial stone. [less ▲]

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See detailThe influence of cognitive reserve on inter-individual variability in resting-state cerebral metabolism in normal aging
Bastin, Christine ULg; Yakushev, Igor; Bahri, Mohamed Ali ULg et al

in Frontiers in Human Neuroscience (2012)

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