References of "2012"
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See detailSul Virgilio palestinese del ‘nuovo’ PColt II 2
Scappaticcio, Maria Chiara ULg

in Analecta Papyrologica (2012)

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See detailImatinib and Nilotinib Inhibit Hematopoietic Progenitor Cell Growth, but Do Not Prevent Adhesion, Migration and Engraftment of Human Cord Blood CD34+ Cells
Belle, Ludovic ULg; Bruck, France; FOGUENNE, Jacques ULg et al

in PLoS ONE (2012), 7(12), 52564

Background: The availability of tyrosine kinase inhibitors (TKIs) has considerably changed the management of Philadelphia chromosome positive leukemia. The BCR-ABL inhibitor imatinib is also known to ... [more ▼]

Background: The availability of tyrosine kinase inhibitors (TKIs) has considerably changed the management of Philadelphia chromosome positive leukemia. The BCR-ABL inhibitor imatinib is also known to inhibit the tyrosine kinase of the stem cell factor receptor, c-Kit. Nilotinib is 30 times more potent than imatinib towards BCR-ABL in vitro. Studies in healthy volunteers and patients with chronic myelogenous leukemia or gastrointestinal stromal tumors have shown that therapeutic doses of nilotinib deliver drug levels similar to those of imatinib. The aim of this study was to compare the inhibitory effects of imatinib and nilotinib on proliferation, differentiation, adhesion, migration and engraftment capacities of human cord blood CD34+ cells. Design and Methods: After a 48-hour cell culture with or without TKIs, CFC, LTC-IC, migration, adhesion and cell cycle analysis were performed. In a second time, the impact of these TKIs on engraftment was assessed in a xenotransplantation model using NOD/SCID/IL-2Rc (null) mice. <br />Results: TKIs did not affect LTC-IC frequencies despite in vitro inhibition of CFC formation due to inhibition of CD34+ cell cycle entry. Adhesion of CD34+ cells to retronectin was reduced in the presence of either imatinib or nilotinib but only at high concentrations. Migration through a SDF-1a gradient was not changed by cell culture in the presence of TKIs. Finally, bone marrow cellularity and human chimerism were not affected by daily doses of imatinib and nilotinib in a xenogenic transplantation model. No significant difference was seen between TKIs given the equivalent affinity of imatinib and nilotinib for KIT. <br />Conclusions: These data suggest that combining non-myeloablative conditioning regimen with TKIs starting the day of the transplantation could be safe. [less ▲]

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See detailSmouldering malignant melanoma and metastatic dormancy: an update and review.
PIERARD, Gérald ULg; PIERARD-FRANCHIMONT, Claudine ULg; REGINSTER, Marie-Annick ULg et al

in Dermatology Research and Practice (2012), 2012

The fund of knowledge regarding the versatility of presentation of MM metastases is still quite incomplete. The recent literature pertaining to the current understanding of the mechanisms underlying two ... [more ▼]

The fund of knowledge regarding the versatility of presentation of MM metastases is still quite incomplete. The recent literature pertaining to the current understanding of the mechanisms underlying two special features of MM metastasis is reviewed. On the one hand, a long disease-free interval (MM dormancy) may occur before the surge of overt metastases. On the other hand, the so-called MM smouldering phenomenon refers to the condition where regional metastases wax and wane for long periods of time on restricted skin regions. It is important to emphasize that local micrometastases often predict sentinel lymph node involvement but may not reflect progression of the primary MM to full-blown visceral metastatic competence. It is likely that a combination of factors impacts the versatile MM metastasic progression. Among the main factors, one has to mention the phenotypic heterogeneity and variability in the phenotype of MM cells, the presence of MM stem cells and MM cells engaged in an amplification proliferation pool, as well as the host immune response, and possibly the induction of a particular stromal structure and vascularity. [less ▲]

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See detailExercise testing in aortic stenosis and in mitral regurgitation
LANCELLOTTI, Patrizio ULg; Magne, Julien ULg

in Cardiac valvular medicine (2012)

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See detailLANDSAFE: LANDING SITE RISK ANALYSIS SOFTWARE FRAMEWORK
Schmidt, Ralph; Bostelmann, Jonas; Cornet, Yves ULg et al

in International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences (2012), XXXIX(B4), 505-510

The European Space Agency (ESA) is planning a Lunar Lander mission in the 2018 timeframe that will demonstrate precise soft landing at the polar regions of the Moon. To ensure a safe and successful ... [more ▼]

The European Space Agency (ESA) is planning a Lunar Lander mission in the 2018 timeframe that will demonstrate precise soft landing at the polar regions of the Moon. To ensure a safe and successful landing a careful risk analysis has to be carried out. This is comprised of identifying favorable target areas and evaluating the surface conditions in these areas. Features like craters, boulders, steep slopes, rough surfaces and shadow areas have to be identified in order to assess the risk associated to a landing site in terms of a successful touchdown and subsequent surface operation of the lander. In addition, global illumination conditions at the landing site have to be simulated and analyzed. The Landing Site Risk Analysis software framework (LandSAfe) is a system for the analysis, selection and certification of safe landing sites on the lunar surface. LandSAfe generates several data products including high resolution digital terrain models (DTMs), hazard maps, illumination maps, temperature maps and surface reflectance maps which assist the user in evaluating potential landing site candidates. This paper presents the LandSAfe system and describes the methods and products of the different modules. For one candidate landing site on the rim of Shackleton crater at the south pole of the Moon a high resolution DTM is showcased. * Corresponding [less ▲]

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See detailEvaluation of species richness estimators based on quantitative performance measures and sensitivity to patchiness and sample grain size
Willie, Jacob; Petre, Charles-Albert ULg; Tagg, Nikki et al

in Acta Oecologica: International Journal of Ecology (2012)

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See detailLa Domus dei Bucrani e il sistema decorativo dell’oecus dei Nani
Morard, Thomas ULg; Girard, Thibault

in Bocherens, Christophe (Ed.) Nani in Festa. Iconografia, religione e politica a Ostia durante il secondo triumvirato (2012)

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See detailPh Ib/II study of BKM120 plus trastuzumab in patients with trastuzumab-resistant HER2+ advanced breast cancer
Pistilli, Barbara; Urruticoechea, Ander; Chan Stephen et al

in Annals of Oncology (2012), 23(supplément 9), 116

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See detailImpairment of assets (IAS 36), a consistent application, to what extent?
Yammine, Mira ULg

Conference (2012)

The objective of this paper is to determine whether the application of impairment of assets -IAS 36- is consistent among companies and countries. The study covers 302 companies in 16 countries which ... [more ▼]

The objective of this paper is to determine whether the application of impairment of assets -IAS 36- is consistent among companies and countries. The study covers 302 companies in 16 countries which mandate the application of IFRS for listed and consolidated companies. A descriptive analysis was performed on information obtained from financial statements for the reporting year 2008. This same information was used for linear and logistic regressions that were conducted on a number of variables that are determined from the literature to have an impact on the impairment recognition and magnitude. Some of these variables such as return, market to book ratio and leverage were found to have an impact on the impairment decision and magnitude. The impact of these variables was different whether we consider all countries pooled together or whether we put European and Non-European countries in separate groups. If we go further and treat each country individually, when enough companies are available, we notice that the impact of these variables still is different. In addition, the study showed differences in percentage of non-explained variables embedded in the residuals obtained from the regressions performed on individual and grouped countries. These differences are an indication of the presence of factors that affect the consistent application of IFRS. Some of these factors are difference in interpretation, influence of domestic accounting standards, culture and enforcement bodies. [less ▲]

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See detailÉvaporation d’une gouttelette en chute libre dans l’air
Massinon, Mathieu ULg; Lebeau, Frédéric ULg

Software (2012)

Simple model taking into account the movement and transfer of heat and mass at the droplet in free fall in the air.

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See detailVers long, vers court, lieux de différenciation lexicale et linguistique : le cas du distique élégiaque latin
Purnelle, Gérald ULg

in Dister, Anne; Longrée, Dominique; Purnelle, Gérald (Eds.) JADT 2012 – Actes des 11es Journées internationales d'Analyse statistique des Données Textuelles (2012)

Basing itself on an exemplary case in Latin poetry, this paper will ask two questions: does metrical form have an influence on the linguistic and lexical choices of a poet? Can short and long verses in a ... [more ▼]

Basing itself on an exemplary case in Latin poetry, this paper will ask two questions: does metrical form have an influence on the linguistic and lexical choices of a poet? Can short and long verses in a given poetry be differentiated using lexical, grammatical (Part of Speech frequency) and length of words criteria? The corpus used in this research is based on a precise Latin poetic form, the elegiac couplet, made of a dactylic hexameter followed by a dactylic pentameter, two verses of different length and structure. It is composed of 9 works from 4 different authors and is divided in 48 subsets. Each text of the corpus is systematically parted in two subsets, hexameters and pentameters, so as to be able to oppose a formal parameter (verse length) to other parameters (author and text topics). [less ▲]

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See detailAbnormal vascular architecture at the placental-maternal interface in placenta increta
CHANTRAINE, Frédéric ULg; Blacher, Silvia ULg; Berndt, Sarah et al

in American Journal of Obstetrics and Gynecology (2012), 207(3), 1881-9

Objective The objective of the study was to characterize the vascular architecture at the placental-maternal interface in pregnancies complicated by placenta increta and normal pregnancies. Study Design ... [more ▼]

Objective The objective of the study was to characterize the vascular architecture at the placental-maternal interface in pregnancies complicated by placenta increta and normal pregnancies. Study Design Vessel numbers and cross-section area density and spatial and area distributions in 13 placenta-increta placental beds were compared with 9 normal placental beds using computer-assisted image analysis of whole-slide CD31 immunolabeled sections. Results The total areas occupied by vessels in normal and placenta-increta placental beds were comparable, but vessels were significantly sparser and larger in the latter. Moreover, placenta-increta–vessel distributions (area and distance from the placental–myometrial junction) were more heterogeneous. Conclusion Size and spatial organization of the placenta-increta vascular architecture at the placental-maternal interface differed from normal and might partially explain the severe hemorrhage observed during placenta-increta deliveries. [less ▲]

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See detailLa compatibilité du métier de secrétaire communal avec d’autres fonctions : aperçu de lege lata, de lege peractura et de lege ferenda
Donnay, Luc ULg

in L'indépendance du secrétaire communal : utopie ou réalité? (2012)

Il s'agit d'un examen de la compatibilité du métier de secrétaire communal avec d'autres fonctions au regard de la situation législative actuelle et des projets de réformes en cours.

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See detailCompte-rendu de l'ouvrage de Arnaud Hurel et Noël Coye, Dans l'épaisseur du temps. Archéologue et géologues invent la Préhistoire
Noiret, Pierre ULg

in Revue du Nord. Archéologie de la Picardie et du Nord de la France (2012), 94(398), 268-270

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See detailComparison of different approaches to evaluate External Quality Assessment Data.
Coucke, Wim; China, Bernard; Delattre, Isabelle et al

in Clinica Chimica Acta (2012), 413(5-6), 582-6

In EQA programs, Z-scores are used to evaluate laboratory performance. They should indicate poorly performing laboratories, regardless of the presence of outliers. For this, two different types of ... [more ▼]

In EQA programs, Z-scores are used to evaluate laboratory performance. They should indicate poorly performing laboratories, regardless of the presence of outliers. For this, two different types of approaches exist. The first type are "outlier-based" approaches, which first exclude outlying values, calculate the average and standard deviation on the remaining data and obtain Z-scores for all values (e.g., Grubbs and Dixon). The second type includes the "robust" approaches (e.g., Tukey and Qn or the algorithm recommended by ISO). The different approaches were assessed by randomly generated samples from the Normal and Student t distributions. Part of the sample data were contaminated with outliers. The number of false and true outliers was recorded and subsequently, Positive and Negative Predictive Values were derived. Also, the sampling mean and variability were calculated for location and scale estimators. The various approaches performed similarly for sample sizes above 10 and when outliers were at good distance from the centre. For smaller sample sizes and closer outliers, however, the approaches performed quite differently. Tukey's method was characterised by a high true and a high false outlier rate, while the ISO and Qn approaches demonstrated weak performance. Grubbs test yielded overall the best results. [less ▲]

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See detailA longirostrine Temnodontosaurus (Ichthyosauria) with comments on Early Jurassic ichthyosaur niche partitioning and disparity
Martin, Jeremy; Fischer, Valentin ULg; Vincent, Peggy et al

in Palaeontology (2012), 55(1), 9951005

We describe an almost complete ichthyosaur skeleton from the middle Toarcian (Lower Jurassic) of the Beaujolais foothills near Lyon, France, and assign it to Temnodontosaurus azerguensis sp. nov. This new ... [more ▼]

We describe an almost complete ichthyosaur skeleton from the middle Toarcian (Lower Jurassic) of the Beaujolais foothills near Lyon, France, and assign it to Temnodontosaurus azerguensis sp. nov. This new species exhibits cranial peculiarities such as a thin, elongated and possibly edentulous rostrum, as well as a reduced quadrate. These characters indicate dietary preferences that markedly differ from other species referred to Temnodontosaurus, a genus previously considered as the top predator of the Early Jurassic seas. Despite a conservative postcranial skeleton, we propose that Temnodontosaurus is one of the most ecologically disparate genera of ichthyosaurs, including apex predators and now a soft prey longirostrine hunter. Ammonites collected from the same stratigraphic level as the described specimen indicate that the new species is somewhat younger (bifrons ammonite zone) than the most known Toarcian ichthyosaurs and therefore slightly postdates the interval of severe environmental changes and marine invertebrate extinctions known as the Toarcian Oceanic Anoxic Event. The present study therefore raises the question of whether postcrisis recovery of vertebrate faunas, including the radiation of Temnodontosaurus into a new ecological niche, may have been a consequence of marine ecosystem reorganization across this event. [less ▲]

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See detailHITUBES PROJECT DESIGN AND INTEGRITY ASSESSMENT OF HIGH STRENGTH TUBULAR STRUCTURES FOR EXTREME LOADING CONDITIONS - D8
Bursi, Oreste S.; Kumar, Anil; Demonceau, Jean-François ULg

Report (2012)

D8.1: Evaluation of the results of the SWOT analysis. D8.2: Evaluation of the results of the monitoring activity.

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See detailImpact of an anxious social situation on emotional facial expressions (EFEs) recognition in children
Dethier, Marie ULg; Taskin, Aslihan Serap; Blairy, Sylvie ULg

in Revue Francophone de Clinique Comportementale et Cognitive (2012), 17(2), 2-9

This study addresses the relationship between the capacity of emotional facial expressions (EFEs) recognition and self-esteem in children placed in an anxious social situation. Seventy children (8 – 12 ... [more ▼]

This study addresses the relationship between the capacity of emotional facial expressions (EFEs) recognition and self-esteem in children placed in an anxious social situation. Seventy children (8 – 12 years) were placed in an anxious social situation of performance in which they were instructed to count aloud backwards, beginning at 200 in decrements of 13. After that, children were assessed on a decoding test of 16 photographs depicting EFE. For each photograph, they evaluated the presence of nine types of emotions. They also completed the Self-Perception Profile for Children (Pierrehumbert et al., 1987). No correlations emerged between the accuracy of EFE recognition and an increase of anxious feelings after the anxious social situation. However, self-esteem was correlated with performance on the EFE recognition test. Moreover, the lower the child’s level of self-esteem was, the more he/she perceived negative emotions in EFEs. In conclusion, social anxiety doesn’t seem to interfere with EFEs recognition performance in an anxious social situation. However, low level of self-esteem in children appears to be associated with deficits and interpretative bias in EFEs recognition in an anxious social situation. [less ▲]

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See detailRecension de l'ouvrage de M. IACUB, "Une société de violeurs?" (Paris, Fayard, 2012)
Thirion, Nicolas ULg

in Journal des Tribunaux (2012)

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