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See detailMicellar electrokinetic chromatography systems for the separation of mixtures of charged and uncharged compounds
Lamalle, Caroline ULg; Servais, Anne-Catherine ULg; Fradi, Ines ULg et al

in Journal of Separation Science (2012), 35(15), 1933-1939

In this study, the migration behavior of charged and uncharged analytes was investigated under different conditions. Effective mobilities - electrophoretic mobilities under the influence of micelles - of ... [more ▼]

In this study, the migration behavior of charged and uncharged analytes was investigated under different conditions. Effective mobilities - electrophoretic mobilities under the influence of micelles - of cations, anions, and neutrals were measured at neutral, basic, and acidic pH (7.5, 11, and 2.2) using background electrolytes containing different sodium dodecyl sulfate (SDS) concentrations (0-90 mM) and acetonitrile (ACN) proportions (0-75%). SDS concentration and ACN proportion were found to have a tremendous effect on the effective mobilities and migration order of the model compounds. Although the SDS micelles preferably interact with neutrals and cations, hydrophobic bonds can also occur with anions. Cations, anions, and neutrals having rather different migration behaviors, it is possible to considerably enhance the selectivity of the method by adjusting properly the SDS concentration and the ACN proportion. These observations confirm the interest of using micellar electrokinetic chromatography not only for the separation of neutral substances but also to analyze charged compounds. [less ▲]

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See detailMicrostructure analyses and thermoelectric properties of Ag1-xPb18Sb1+yTe20
Perlt, S.; Hoeche, Th; Dadda, J. et al

in Journal of Solid State Chemistry (2012), 193(SI), 58-63

This study reports microstructural investigations of long-term annealed 18, x=y=0, hereinafter referred to as AgPb18SbTe20) (Lead-Antimony-Silver-Tellurium, LAST-18) as well as of Ag1-xPb18Sb1+yTe20, i.e ... [more ▼]

This study reports microstructural investigations of long-term annealed 18, x=y=0, hereinafter referred to as AgPb18SbTe20) (Lead-Antimony-Silver-Tellurium, LAST-18) as well as of Ag1-xPb18Sb1+yTe20, i.e. Ag-deficient and Sb-excess LAST-18 (x not equal 0, y not equal 0), respectively. Two different length scales are explored. The micrometer scale was evaluated by SEM to analyze the volume fraction and the number of secondary phases as well as the impact of processing parameters on the homogeneity of bulk samples. For AgPb18SbTe20, site-specific FIB liftout of TEM lamellae from thermoelectrically characterized samples was accomplished to investigate the structure on the nanometer scale. High-resolution TEM and energy-filtered TEM were performed to reveal shape and size distribution of nanoprecipitates, respectively. A hypothesis concerning the structure-property relationship is set out within the frame of a gradient annealing experiment. This study is completed by results dealing with inhomogeneities on the micrometer scale of Ag1-xPb18Sb1+yTe20 and its electronic properties. (C) 2012 Elsevier Inc. All rights reserved. [less ▲]

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See detailA panel of biological tests reveals developmental effects of pharmaceutical pollutants on late stage zebrafish embryos.
Pruvot, Benoist ULg; Quiroz O' Donova, Yobhana ULg; Voncken, Audrey ULg et al

in Reproductive Toxicology (2012)

Standard toxicological assays using the zebrafish model system evaluate lethality and teratogenicity upon exposure during the first two days after fertilization. We tested the biological effects of ... [more ▼]

Standard toxicological assays using the zebrafish model system evaluate lethality and teratogenicity upon exposure during the first two days after fertilization. We tested the biological effects of several widely used drugs on zebrafish by acute treatment for 24hours starting at late embryonic stages, between 48 and 72hours post-fertilization. For 4 out of 6 compounds, we observed a higher sensitivity of late stage zebrafish embryos for general toxicity (lethality) compared to younger embryos. Morphological defects such as edema, body curvature, delayed growth, decreased heart rate and locomotion were observed for each of the compounds tested, often at sublethal concentrations. Gene expression studies on a set of four selected genes revealed a specific regulatory pattern for the different compounds tested. Our results allow us to compare various toxicological endpoints and may contribute to the design of a rational high throughput approach using the zebrafish model. [less ▲]

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See detailEfficacy of powdered maize cobs against the maize weevil Sitophilus zeamais (Coleoptera: Curculionidae) in stored maize in Senegal
Gueye, Talla Momar; Cissokho, Papa Seyni; Goergen, Georg et al

in International Journal of Tropical Insect Science (2012)

Powdered maize cobs were tested as an alternative for pesticide use in stored maize. Five doses (2, 4, 6, 8 and 10 g/250 g seed) of powdered maize cobs applied at particle sizes of 1.4 and 0.4mm diameter ... [more ▼]

Powdered maize cobs were tested as an alternative for pesticide use in stored maize. Five doses (2, 4, 6, 8 and 10 g/250 g seed) of powdered maize cobs applied at particle sizes of 1.4 and 0.4mm diameter were compared with actellic powder against Sitophilus zeamais Motschulsky for 120 days. Mortality and survival data showed that cob powders did not act as fumigant but exerted a potent inhibition of progeny on direct contact with S. zeamais adults. The particle size of powdered cobs had no effect on maize damage and losses. At doses equal to or higher than 6 g powdered maize cobs/250 g grain maize, i.e. 2.4% (w/w), damage to grain was ,5% and weight losses ,1%. The protection offered at the highest dose was comparable to the pesticide control. The use of powdered maize cobs is discussed as a natural alternative to synthetic pesticides for protection of maize against S. zeamais. [less ▲]

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See detailAdalimumab in ulcerative colitis: can pharmacodynamics be improved based on pharmacokinetics?
LOUIS, Edouard ULg; Panes, Julian

in Gastroenterology (2012), 142(1), 176-8

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See detailWhy do Congolese people go to court? A qualitative study of litigants’ careers in two justice of the peace courts in Lubumbashi, D.R.Congo
Rubbers, Benjamin ULg; Gallez, Emilie

in Journal of Legal Pluralism and Unofficial Law (2012), 66

Although JP courts did not escape the general deterioration of Congolese administrative structures, Congolese people continue to use these courts to resolve their conflicts. Based on qualitative research ... [more ▼]

Although JP courts did not escape the general deterioration of Congolese administrative structures, Congolese people continue to use these courts to resolve their conflicts. Based on qualitative research carried out in Lubumbashi, this article attempts to understand why people bring their cases to the JP court. How do litigants make that decision in the first place? Once their cases are underway, how do they deal with the trial? The authors emphasise the fact that while litigants denounce the corruption that occurs within the legal system, they continue nevertheless to have confidence in justice itself and in the State. This faith reflects the importance of the law and the formal ideal of institutions that were inherited from the Belgian colonial period in various areas of the daily life of Congolese people. But it also suggests that, counter to the dominant paradigm in the study of the State in Africa, these institutional norms do not simply represent an illusion without basis in reality. Where circumstances allow, these norms do indeed play a structuring role in the functioning of bureaucracy in Congo. [less ▲]

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See detailSur les traces des saints thébains en pays mosan
George, Philippe ULg

in Brocard, N.; Vannotti, Fr.; Wagner, A. (Eds.) Politique, société et construction identitaire : autour de saint Maurice (2012)

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See detailOverexpression of GRP94 in breast cancer cells resistant to oxidative stress promotes high levels of cancer cell proliferation and migration: implications for tumor recurrence.
Dejeans, Nicolas; Glorieux, Christophe; Guénin, Samuel ULg et al

in Free Radical Biology & Medicine (2012), 52(6), 993-1002

Targeting the altered redox status of cancer cells is emerging as an interesting approach to potentiate chemotherapy. However, to maximize the effectiveness of this strategy and define the correct ... [more ▼]

Targeting the altered redox status of cancer cells is emerging as an interesting approach to potentiate chemotherapy. However, to maximize the effectiveness of this strategy and define the correct chemotherapeutic associations, it is important to understand the biological consequences of chronically exposing cancer cells to reactive oxygen species (ROS). Using an H(2)O(2)-generating system, we selected a ROS-resistant MCF-7 breast cancer cell line, namely Resox cells. By exploring different survival pathways that are usually induced during oxidative stress, we identified a constitutive overexpression of the endoplasmic reticulum chaperone, GRP94, in these cells, whereas levels of its cytoplasmic homolog HSP90, or GRP78, were not modified. This overexpression was not mediated by constitutive unfolded protein response (UPR) activation. The increase in GRP94 is tightly linked to an increase in cell proliferation and migration capacities, as shown by GRP94-silencing experiments. Interestingly, we also observed that GRP94 silencing inhibits migration and proliferation of the highly aggressive MDA-MB-231 cells. By immunohistochemistry, we showed that GRP94 expression was higher in recurrent human breast cancers than in their paired primary neoplasias. Similar to the situation in the Resox cells, this increase was not associated with an increase in UPR activation in recurrent tumors. In conclusion, this study suggests that GRP94 overexpression may be a hallmark of aggressiveness and recurrence in breast cancers. [less ▲]

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See detailBelgian Magdalenes. History of an aborted scandal?
Dumortier, Els; François, Aurore ULg

Conference (2012)

The analysis of cases of several Belgian juvenile courts (Antwerp, Brussels, Namur, Arlon) revealed questionable practices within some establishments for young delinquents. One institution in particular ... [more ▼]

The analysis of cases of several Belgian juvenile courts (Antwerp, Brussels, Namur, Arlon) revealed questionable practices within some establishments for young delinquents. One institution in particular (Refuge Sainte Madeleine, Brussels), specialized in the rehabilitation of delinquent (and often pregnant) girls, developed suspicious methods of treatment. Indications of dysfunction in this private institution are numerous, and present a lot of similarities with practices observed in Irish Magdalene Asylums: teenage girls employed in a laundry run by a religious congregation, unexplained « disappearances » of the children born to delinquent girls, very high death rates, complaints from minors themselves and from their families regarding forms of negligence and even abuse. This local example leads us to question the practices of the Belgian protection system, and more specifically, the ‘pedogical approach’ in Magdalena covents. How to describe and explain the ‘pedagogical approach’ implemented within these institutions? What is the daily life of the institutionalized girls taking into account their living conditions and implemented discipline? Who worked in these private institutions? Were they trained in modern techniques of rehabilitation, and if so, what principles and applications were associated with these techniques? What is the influence of the Belgian separation between public and private sector with the child protection system? This case also invites us to examine the tension between official discourse and practice and raises questions on gendered reactions within the Belgian system. [less ▲]

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See detailDifferential effects of olanzapine and risperidone on plasma adiponectin levels over time: Results from a 3-month prospective open-label study.
Wampers, M.; Hanssens, L.; van Winkel, R. et al

in European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology (2012), 22

Second-generation antipsychotics (SGA), especially clozapine and olanzapine, are associated with an increased metabolic risk. Recent research showed that plasma adiponectin levels, an adipocyte-derived ... [more ▼]

Second-generation antipsychotics (SGA), especially clozapine and olanzapine, are associated with an increased metabolic risk. Recent research showed that plasma adiponectin levels, an adipocyte-derived hormone that increases insulin sensitivity, vary in the same way in schizophrenic patients as in the general population according to gender, adiposity and metabolic syndrome (MetS). The aim of the present study was to investigate whether different SGAs differentially affect plasma adiponectin levels independent of body mass index (BMI) and MetS status. 113 patients with schizophrenia (65.5% males, 32.3years old) who were free of antipsychotic medication were enrolled in this open-label prospective single-center study and received either risperidone (n=54) or olanzapine (n=59). They were followed prospectively for 12weeks. Average daily dose was 4.4mg/day for risperidone and 17.4mg/day for olanzapine. Plasma adiponectin levels as well as fasting metabolic parameters were measured at baseline, 6weeks and 12weeks. The two groups had similar baseline demographic and metabolic characteristics. A significant increase in body weight was observed over time. This increase was significantly larger in the olanzapine group than in the risperidone group (+7.0kg versus +3.1kg, p<0.0002). Changes in fasting glucose and insulin levels and in HOMA-IR, an index of insulin resistance, were not significantly different in both treatment groups. MetS prevalence increased significantly more in the olanzapine group as compared to the risperidone groups where the prevalence did not change over time. We observed a significant (p=0.0015) treatment by time interaction showing an adiponectin increase in the risperidone-treated patients (from 10,154 to 11,124ng/ml) whereas adiponectin levels decreased in olanzapine treated patients (from 11,280 to 8988ng/ml). This effect was independent of BMI and the presence/absence of MetS. The differential effect of antipsychotic treatment (risperidone versus olanzapine) on plasma adiponectin levels over time, independent of changes in waist circumference and antipsychotic dosing, suggests a specific effect on adipose tissues, similar to what has been observed in animal models. The observed olanzapine-associated reduction in plasma adiponectin levels may at least partially contribute to the increased metabolic risk of olanzapine compared to risperidone. [less ▲]

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See detailDark Matter in a SUSY Left-Right Model
Vicente, Avelino ULg

in Journal of Physics: Conference Series (2012), 375

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See detailDes rizières aux parcs industriels : quels enjeux pour le développement rural au Vietnam; Transformations récentes et persistance de l'importance de l'économie rizicole dans l'économie paysanne : Leçons des expériences menées au Viêtnam dans le cadre de la Coopération universitaire; Agricultural land issues in the vietnamese industrialisation period and its impacts on the countryside
Lebailly, Philippe ULg; Vu Dinh, Ton

Book published by Centres d'Etudes du Développement, UCL; Unité d'Economie et Développement rural, Gembloux Agro-Bio Tech, ULG; Centre for Interdisciplinary Research on Rural Development (CIRRD), Hanoi University of Agriculture (HUA) (2012)

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See detailESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation.
Steg, Ph Gabriel; James, Stefan K.; Atar, Dan et al

in European Heart Journal (2012), 33(20), 2569-619

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See detailFaut-il operer les petits anevrysmes poplites asymptomatiques?
Holemans, Ch; VAN DAMME, Hendrik ULg; Defraigne, Jean-Olivier ULg

in Revue medicale de Liege (2012), 67(11), 576-81

The authors recently observed two patients who suffered acute lower limb ischemia secondary to thrombosis of a small (diameter of less than 2 cm) popliteal artery aneurysm. A literature search lead to the ... [more ▼]

The authors recently observed two patients who suffered acute lower limb ischemia secondary to thrombosis of a small (diameter of less than 2 cm) popliteal artery aneurysm. A literature search lead to the conclusion that small popliteal aneurysms, covered with mural thrombus and presenting a distorted neck due to elongation, are prone to thrombosis. Another risk factor is a restrained outflow bed as a result of previous micro-embolisations into the tibial arteries. The authors conclude that small popliteal artery aneurysms are not so innocent as is often presumed. [less ▲]

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See detailStudy of the factors involved in the aggregation of Harmonia axyridis Pallas (Coleoptera : Coccinellidae)
Durieux, Delphine ULg; Fischer, Christophe ULg; Deneubourg, Jean-Louis et al

in Communications in Agricultural and Applied Biological Sciences (2012), 77(1), 101-104

The aggregative behaviour of the multicoloured Asian ladybeetle, Harmonia axyridis Pallas, during winters, is still misunderstood. Our study was focused on the chemical and physical factors involved in ... [more ▼]

The aggregative behaviour of the multicoloured Asian ladybeetle, Harmonia axyridis Pallas, during winters, is still misunderstood. Our study was focused on the chemical and physical factors involved in the selection of its aggregation sites. Chemical and behavioural analyses highlighted that long-chain hydrocarbons lead congeners towards aggregations and ensure the cohesion of the cluster. On the other hand, we investigated the influence of (1) the density of individuals and (2) the quality of available shelters on H. axyridis decision to settle and aggregate under shelters. A binary choice experiment conducted in laboratory highlighted a permanent aggregative behaviour of H. axyridis, even during non-wintering conditions, and the existence of social interactions between individuals. [less ▲]

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See detailImatinib and Nilotinib Inhibit Hematopoietic Progenitor Cell Growth, but Do Not Prevent Adhesion, Migration and Engraftment of Human Cord Blood CD34+ Cells
Belle, Ludovic ULg; Bruck, France; FOGUENNE, Jacques ULg et al

in PLoS ONE (2012), 7(12), 52564

Background: The availability of tyrosine kinase inhibitors (TKIs) has considerably changed the management of Philadelphia chromosome positive leukemia. The BCR-ABL inhibitor imatinib is also known to ... [more ▼]

Background: The availability of tyrosine kinase inhibitors (TKIs) has considerably changed the management of Philadelphia chromosome positive leukemia. The BCR-ABL inhibitor imatinib is also known to inhibit the tyrosine kinase of the stem cell factor receptor, c-Kit. Nilotinib is 30 times more potent than imatinib towards BCR-ABL in vitro. Studies in healthy volunteers and patients with chronic myelogenous leukemia or gastrointestinal stromal tumors have shown that therapeutic doses of nilotinib deliver drug levels similar to those of imatinib. The aim of this study was to compare the inhibitory effects of imatinib and nilotinib on proliferation, differentiation, adhesion, migration and engraftment capacities of human cord blood CD34+ cells. Design and Methods: After a 48-hour cell culture with or without TKIs, CFC, LTC-IC, migration, adhesion and cell cycle analysis were performed. In a second time, the impact of these TKIs on engraftment was assessed in a xenotransplantation model using NOD/SCID/IL-2Rc (null) mice. <br />Results: TKIs did not affect LTC-IC frequencies despite in vitro inhibition of CFC formation due to inhibition of CD34+ cell cycle entry. Adhesion of CD34+ cells to retronectin was reduced in the presence of either imatinib or nilotinib but only at high concentrations. Migration through a SDF-1a gradient was not changed by cell culture in the presence of TKIs. Finally, bone marrow cellularity and human chimerism were not affected by daily doses of imatinib and nilotinib in a xenogenic transplantation model. No significant difference was seen between TKIs given the equivalent affinity of imatinib and nilotinib for KIT. <br />Conclusions: These data suggest that combining non-myeloablative conditioning regimen with TKIs starting the day of the transplantation could be safe. [less ▲]

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See detailAlimentation de l’enfant
de Suremain, Charles-Edouard; Razy, Elodie ULg

in Poulain, Jean-Pierre (Ed.) Dictionnaire des cultures et des modèles alimentaires (2012)

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See detailMulti-terminal HVDC systems and ancillary services
Ernst, Damien ULg

Speech/Talk (2012)

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See detailDetection and quantification of human papillomavirus in benign and malignant parotid lesions.
Descamps, Geraldine; Duray, Anaelle; Rodriguez, Alexandra et al

in Anticancer Research (2012), 32(9), 3929-32

Background/Aim: Human papillomavirus (HPV) is implicated in head and neck squamous cell carcinomas. However, the causal role of HPV in carcinomas of the parotid gland remains uncertain and less documented ... [more ▼]

Background/Aim: Human papillomavirus (HPV) is implicated in head and neck squamous cell carcinomas. However, the causal role of HPV in carcinomas of the parotid gland remains uncertain and less documented. This study aimed to determine the potential implication of HPV in the development of benign and malignant lesions of the parotid gland. MATERIALS AND METHODS: Paraffin-embedded biopsies were obtained from 40 patients with benign parotid gland tumors and from 39 patients with parotid gland carcinomas. The 79 samples were evaluated for the presence of HPV DNA using both GP5+/GP6+ consensus Polymerase Chain Reaction (PCR) and type-specific E6/E7 PCR to detect 18 HPV types. RESULTS: Our results showed a low prevalence of HPV, with only three HPV-positive cases among the 40 benign tumors and one infected carcinoma in the malignant population. CONCLUSION: No association between the presence of HPV DNA and the development of parotid gland tumors was found in our study. [less ▲]

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See detailModerate chemical modifications of WAY-100635 improve the selectivity for 5-HT1A versus D4 receptors
Mangin, Floriane; Dilly, Sébastien ULg; Joly, Benoît ULg et al

in Bioorganic & Medicinal Chemistry Letters (2012)

The selectivity for 5-HT1A versus D4 receptors is significantly increased when the basic side chain of WAY-100635 is replaced by a 4-phenylpiperazine (3e) or a 4-phenyl-1,2,3,6-tetrahydropyridine moiety ... [more ▼]

The selectivity for 5-HT1A versus D4 receptors is significantly increased when the basic side chain of WAY-100635 is replaced by a 4-phenylpiperazine (3e) or a 4-phenyl-1,2,3,6-tetrahydropyridine moiety (3i). The 4-phenyl-1,2,3,6-tetrahydropyridine compounds (3i-l) have a higher affinity for 5-HT1A receptors than do the corresponding unsubstituted phenylpiperazine analogues (3e-h). Compounds 3e and 3i appear to be selective for 5-HT1A receptors over other relevant receptors and still behave as neutral antagonists. [less ▲]

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