References of "2012"
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See detailSur les traces des saints thébains en pays mosan
George, Philippe ULg

in Brocard, N.; Vannotti, Fr.; Wagner, A. (Eds.) Politique, société et construction identitaire : autour de saint Maurice (2012)

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See detailESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation.
Steg, Ph Gabriel; James, Stefan K.; Atar, Dan et al

in European Heart Journal (2012), 33(20), 2569-619

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See detailFaut-il operer les petits anevrysmes poplites asymptomatiques?
Holemans, Ch; VAN DAMME, Hendrik ULg; Defraigne, Jean-Olivier ULg

in Revue medicale de Liege (2012), 67(11), 576-81

The authors recently observed two patients who suffered acute lower limb ischemia secondary to thrombosis of a small (diameter of less than 2 cm) popliteal artery aneurysm. A literature search lead to the ... [more ▼]

The authors recently observed two patients who suffered acute lower limb ischemia secondary to thrombosis of a small (diameter of less than 2 cm) popliteal artery aneurysm. A literature search lead to the conclusion that small popliteal aneurysms, covered with mural thrombus and presenting a distorted neck due to elongation, are prone to thrombosis. Another risk factor is a restrained outflow bed as a result of previous micro-embolisations into the tibial arteries. The authors conclude that small popliteal artery aneurysms are not so innocent as is often presumed. [less ▲]

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See detailDo results of the EORTC dummy run predict quality of radiotherapy delivered within multicentre clinical trials?
Fairchild, A.; Collette, L.; Hurkmans, C. W. et al

in European Journal of Cancer (2012), 48(17), 3232-3239

Objective: The European Organisation for the Research and Treatment of Cancer (EORTC) Radiation Oncology Group (ROG) has performed radiotherapy quality assurance (QA) in clinical trials, including dummy ... [more ▼]

Objective: The European Organisation for the Research and Treatment of Cancer (EORTC) Radiation Oncology Group (ROG) has performed radiotherapy quality assurance (QA) in clinical trials, including dummy runs (DR) and individual case reviews (ICR), since 1991. We investigated the influence of DR results on subsequent QA and patient outcomes. Methods: EORTC ROG studies were reviewed for DR inclusion, QA and mature clinical outcomes. A DR was classified as a failure if corrections necessitated re-submission. ICR were graded as acceptable, minor or major deviation overall. Fisher's exact test characterised potential correlations and the Mantel-Haenszel statistic quantified pooled odds ratios (OR). Results: DR and ICR data were available from 12 and 3 protocols, respectively. The proportion of institutions successful at first DR attempt varied per trial from 5.6% to 68.8%. Participants were 3.2 times more likely to pass at first attempt after previous DR participation (p = 0.0002). Pooled OR for an acceptable ICR was 1.69 (p = 0.06) for institutions successful at DR first attempt. The effect of DR participation was not significantly correlated with patient outcome in the trial available for analysis. Conclusions: Implementing QA measures in ROG clinical trials should ensure optimal radiotherapy delivery. Centres which previously participated in a DR were significantly more likely to be successful at subsequent QA procedures. © 2012 Elsevier Ltd. All rights reserved. [less ▲]

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See detailOverexpression of GRP94 in breast cancer cells resistant to oxidative stress promotes high levels of cancer cell proliferation and migration: implications for tumor recurrence.
Dejeans, Nicolas; Glorieux, Christophe; Guénin, Samuel ULg et al

in Free Radical Biology & Medicine (2012), 52(6), 993-1002

Targeting the altered redox status of cancer cells is emerging as an interesting approach to potentiate chemotherapy. However, to maximize the effectiveness of this strategy and define the correct ... [more ▼]

Targeting the altered redox status of cancer cells is emerging as an interesting approach to potentiate chemotherapy. However, to maximize the effectiveness of this strategy and define the correct chemotherapeutic associations, it is important to understand the biological consequences of chronically exposing cancer cells to reactive oxygen species (ROS). Using an H(2)O(2)-generating system, we selected a ROS-resistant MCF-7 breast cancer cell line, namely Resox cells. By exploring different survival pathways that are usually induced during oxidative stress, we identified a constitutive overexpression of the endoplasmic reticulum chaperone, GRP94, in these cells, whereas levels of its cytoplasmic homolog HSP90, or GRP78, were not modified. This overexpression was not mediated by constitutive unfolded protein response (UPR) activation. The increase in GRP94 is tightly linked to an increase in cell proliferation and migration capacities, as shown by GRP94-silencing experiments. Interestingly, we also observed that GRP94 silencing inhibits migration and proliferation of the highly aggressive MDA-MB-231 cells. By immunohistochemistry, we showed that GRP94 expression was higher in recurrent human breast cancers than in their paired primary neoplasias. Similar to the situation in the Resox cells, this increase was not associated with an increase in UPR activation in recurrent tumors. In conclusion, this study suggests that GRP94 overexpression may be a hallmark of aggressiveness and recurrence in breast cancers. [less ▲]

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See detailKisspeptin-immunoreactivity changes in a sex- and hypothalamic-region-specific manner across rat postnatal development.
Desroziers, Elodie ULg; Mikkelsen, J. D.; Duittoz, A. et al

in Journal of Neuroendocrinology (2012), 24(8), 1154-65

Kisspeptins are potent secretagogues of gonadotrophin-releasing hormone, playing a key role in puberty onset. These peptides are produced by distinct neuronal populations of the hypothalamus located in ... [more ▼]

Kisspeptins are potent secretagogues of gonadotrophin-releasing hormone, playing a key role in puberty onset. These peptides are produced by distinct neuronal populations of the hypothalamus located in the rostral periventricular area of the third ventricle (RP3V) and arcuate nucleus (ARC). The present immunohistochemical study aimed to determine the spatiotemporal onset of kisspeptin-immunoreactivity (-IR) in the neonatal hypothalamus of male and female rats and to evaluate changes in kisspeptin-IR around puberty. Kisspeptin-IR cells and fibres could be detected from the day of birth in the ARC of both males and females. At this stage, only females displayed some kisspeptin-IR fibres in the RP3V. From postnatal day 7 to adulthood, males displayed lower levels of kisspeptin-IR than females in both regions. During infancy, kisspeptin-IR fibre density in the female decreased in the ARC, whereas it increased in the RP3V. A sex-independent decline in RP3V kisspeptin-IR fibre density was observed in the juvenile, followed by a peripubertal increase in RP3V and ARC kisspeptin-IR. These peripubertal increases in kisspeptin-IR occurred at different timings dependent on sex and region. In females specifically, the increase in kisspeptin-IR fibre density occurred first in the ARC and later in the RP3V under constant levels of circulating oestradiol. In conclusion, the present study highlights the expression of hypothalamic kisspeptins soon after birth, as well as the neonatal establishment of a strong and persisting sex difference in ARC kisspeptin-IR in rats. Moreover, a female-specific desynchronisation of the ARC and RP3V was observed with respect to the increase in kisspeptin-IR fibre density around puberty, which was not related to peripubertal variations in circulating oestradiol. [less ▲]

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See detailWhy do Congolese people go to court? A qualitative study of litigants’ careers in two justice of the peace courts in Lubumbashi, D.R.Congo
Rubbers, Benjamin ULg; Gallez, Emilie

in Journal of Legal Pluralism and Unofficial Law (2012), 66

Although JP courts did not escape the general deterioration of Congolese administrative structures, Congolese people continue to use these courts to resolve their conflicts. Based on qualitative research ... [more ▼]

Although JP courts did not escape the general deterioration of Congolese administrative structures, Congolese people continue to use these courts to resolve their conflicts. Based on qualitative research carried out in Lubumbashi, this article attempts to understand why people bring their cases to the JP court. How do litigants make that decision in the first place? Once their cases are underway, how do they deal with the trial? The authors emphasise the fact that while litigants denounce the corruption that occurs within the legal system, they continue nevertheless to have confidence in justice itself and in the State. This faith reflects the importance of the law and the formal ideal of institutions that were inherited from the Belgian colonial period in various areas of the daily life of Congolese people. But it also suggests that, counter to the dominant paradigm in the study of the State in Africa, these institutional norms do not simply represent an illusion without basis in reality. Where circumstances allow, these norms do indeed play a structuring role in the functioning of bureaucracy in Congo. [less ▲]

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See detailMitochondrial transformation and in vitro DNA delivery
Remacle, Claire ULg; Hamel, Patrice; Larosa, Véronique ULg et al

in Bock, R; Knoop, V (Eds.) Genomics of Chloroplasts and Mitochondria (2012)

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See detailGlobal analysis of gene expression in the skin of mice after a 92 days journey in microgravity.
Neutelings, Thibaut ULg; Liu, Y.; Cancedda, R et al

Conference (2012)

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See detailDiagnostic strategy for identifying avian pathogenic Escherichia coli based on four patterns of virulence genes
Schouler, C; Schaeffer, B; Brée, A et al

in Journal of Clinical Microbiology (2012), 50(5), 1673-1678

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See detailDifferential effects of olanzapine and risperidone on plasma adiponectin levels over time: Results from a 3-month prospective open-label study.
Wampers, M.; Hanssens, L.; van Winkel, R. et al

in European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology (2012), 22

Second-generation antipsychotics (SGA), especially clozapine and olanzapine, are associated with an increased metabolic risk. Recent research showed that plasma adiponectin levels, an adipocyte-derived ... [more ▼]

Second-generation antipsychotics (SGA), especially clozapine and olanzapine, are associated with an increased metabolic risk. Recent research showed that plasma adiponectin levels, an adipocyte-derived hormone that increases insulin sensitivity, vary in the same way in schizophrenic patients as in the general population according to gender, adiposity and metabolic syndrome (MetS). The aim of the present study was to investigate whether different SGAs differentially affect plasma adiponectin levels independent of body mass index (BMI) and MetS status. 113 patients with schizophrenia (65.5% males, 32.3years old) who were free of antipsychotic medication were enrolled in this open-label prospective single-center study and received either risperidone (n=54) or olanzapine (n=59). They were followed prospectively for 12weeks. Average daily dose was 4.4mg/day for risperidone and 17.4mg/day for olanzapine. Plasma adiponectin levels as well as fasting metabolic parameters were measured at baseline, 6weeks and 12weeks. The two groups had similar baseline demographic and metabolic characteristics. A significant increase in body weight was observed over time. This increase was significantly larger in the olanzapine group than in the risperidone group (+7.0kg versus +3.1kg, p<0.0002). Changes in fasting glucose and insulin levels and in HOMA-IR, an index of insulin resistance, were not significantly different in both treatment groups. MetS prevalence increased significantly more in the olanzapine group as compared to the risperidone groups where the prevalence did not change over time. We observed a significant (p=0.0015) treatment by time interaction showing an adiponectin increase in the risperidone-treated patients (from 10,154 to 11,124ng/ml) whereas adiponectin levels decreased in olanzapine treated patients (from 11,280 to 8988ng/ml). This effect was independent of BMI and the presence/absence of MetS. The differential effect of antipsychotic treatment (risperidone versus olanzapine) on plasma adiponectin levels over time, independent of changes in waist circumference and antipsychotic dosing, suggests a specific effect on adipose tissues, similar to what has been observed in animal models. The observed olanzapine-associated reduction in plasma adiponectin levels may at least partially contribute to the increased metabolic risk of olanzapine compared to risperidone. [less ▲]

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See detailHeart rate and use of beta-blockers in stable outpatients with coronary artery disease.
Steg, Ph Gabriel; Ferrari, Roberto; Ford, Ian et al

in PLoS ONE (2012), 7(5), 36284

BACKGROUND: Heart rate (HR) is an emerging risk factor in coronary artery disease (CAD). However, there is little contemporary data regarding HR and the use of HR-lowering medications, particularly beta ... [more ▼]

BACKGROUND: Heart rate (HR) is an emerging risk factor in coronary artery disease (CAD). However, there is little contemporary data regarding HR and the use of HR-lowering medications, particularly beta-blockers, among patients with stable CAD in routine clinical practice. The goal of the present analysis was to describe HR in such patients, overall and in relation to beta-blocker use, and to describe the determinants of HR. METHODS AND FINDINGS: CLARIFY is an international, prospective, observational, longitudinal registry of outpatients with stable CAD, defined as prior myocardial infarction or revascularization procedure, evidence of coronary stenosis of >50%, or chest pain associated with proven myocardial ischemia. A total of 33,438 patients from 45 countries in Europe, the Americas, Africa, Middle East, and Asia/Pacific were enrolled between November 2009 and July 2010. Most of the 33,177 patients included in this analysis were men (77.5%). Mean (SD) age was 64.2 (10.5) years, HR by pulse was 68.3 (10.6) bpm, and by electrocardiogram was 67.2 (11.4) bpm. Overall, 44.0% had HR >/= 70 bpm. Beta-blockers were used in 75.1% of patients and another 14.4% had intolerance or contraindications to beta-blocker therapy. Among 24,910 patients on beta-blockers, 41.1% had HR >/= 70 bpm. HR >/= 70 bpm was independently associated with higher prevalence and severity of angina, more frequent evidence of myocardial ischemia, and lack of use of HR-lowering agents. CONCLUSIONS: Despite a high rate of use of beta-blockers, stable CAD patients often have resting HR >/= 70 bpm, which was associated with an overall worse health status, more frequent angina and ischemia. Further HR lowering is possible in many patients with CAD. Whether it will improve symptoms and outcomes is being tested. [less ▲]

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See detailAphid Alarm Pheromone as a Cue for Ants to Locate Aphid Partners
Verheggen, François ULg; Diez, Lise; Sablon, Ludovic ULg et al

in PLoS ONE (2012)

The mutualistic relationships that occur between myrmecophilous aphids and ants are based on the rich food supply that honeydew represents for ants and on the protection they provide against aphid natural ... [more ▼]

The mutualistic relationships that occur between myrmecophilous aphids and ants are based on the rich food supply that honeydew represents for ants and on the protection they provide against aphid natural enemies. While aphid predators and parasitoids actively forage for oviposition sites by using aphid semiochemicals, scouts of aphid-tending ant species would also benefit from locating honeydew resources by orienting toward aphid pheromone sources. The present study aims to provide additional information on the use of Aphis fabae alarm pheromone, i.e. (E)-β-farnesene (EβF), by ant scouts. The perception and behavioral impact of EβF on Lasius niger were investigated using electroantennography and two bio-assays measuring their attraction and orientation towards aphid semiochemicals. Pronounced electrical depolarizations were observed from L. niger scout antennae to stimulations of A. fabae alarm pheromone, while other sesquiterpenes elicited weak or no responses. L. niger scouts were significantly attracted toward EβF in a four-arm olfactometer, as well as in an two-choice bioassay. These laboratory results suggest for the first time that low amounts of aphid alarm pheromone can be used by L. niger scouts as a cue indicating the presence of aphid colonies and could therefore mediate the aphid-ant partnership in the field. [less ▲]

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See detailUse of milk fatty acids to substitute for body condition score in breeding purposes
Bastin, Catherine ULg; Berry, D.P.; Soyeurt, Hélène ULg et al

in Journal of Dairy Science (2012), 95, Suppl. 2

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See detailLes dysphasies : de l'évaluation à la rééducation
Maillart, Christelle ULg; Schelstraete, Marie-Anne

Book published by Elsevier-Masson (2012)

L'étude des troubles du langage oral chez l’enfant a connu un développement considérable à partir des années 1970 avec l’essor des recherches en psychologie du langage, en linguistique, et plus ... [more ▼]

L'étude des troubles du langage oral chez l’enfant a connu un développement considérable à partir des années 1970 avec l’essor des recherches en psychologie du langage, en linguistique, et plus récemment dans le domaine des neurosciences et de la génétique. La prise en charge des troubles langagiers fait également l’objet actuellement d’une attention particulière dans la recherche scientifique. L’objectif principal de ce livre est de rendre accessibles les résultats des recherches récentes sur les troubles dits « dysphasique » aux professionnels concernés par le suivi des enfants présentant cette pathologie. La dysphasie est définie comme un trouble développemental, qui concerne l’élaboration du langage oral, entraînant des difficultés importantes en compréhension et/ou en expression du langage parlé. C’est un trouble spécifique, sévère et persistant qui interfère d’emblée avec la dynamique développementale de l’enfant. La première partie de l’ouvrage expose les approches théo- riques de la dysphasie, actuellement débattues dans la littéra- ture scientifique, et dont la synthèse constitue une aide à l’établissement d’un diagnostic précis ou à la construction de programmes de prévention. La seconde partie présente différents types de rééducation, avec des exemples cliniques, et notamment le courant méthodologique EBP (Evidence-Based Practice), littéralement «pratiques basées sur les preuves», qui vise à aider le clinicien à vérifier la pertinence de ses choix. Illustré par des exemples concrets d’interprétation et d’évaluation des troubles, des stratégies d’élaboration du diagnostic, et comportant les recommandations issues de la littérature internationale, cet ouvrage s’adresse à tous les professionnels concernés par les troubles du langage oral et leur prise en charge : orthophonistes, neuropsychologues, médecins rééducateurs. [less ▲]

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See detailStudy of the factors involved in the aggregation of Harmonia axyridis Pallas (Coleoptera : Coccinellidae)
Durieux, Delphine ULg; Fischer, Christophe ULg; Deneubourg, Jean-Louis et al

in Communications in Agricultural and Applied Biological Sciences (2012), 77(1), 101-104

The aggregative behaviour of the multicoloured Asian ladybeetle, Harmonia axyridis Pallas, during winters, is still misunderstood. Our study was focused on the chemical and physical factors involved in ... [more ▼]

The aggregative behaviour of the multicoloured Asian ladybeetle, Harmonia axyridis Pallas, during winters, is still misunderstood. Our study was focused on the chemical and physical factors involved in the selection of its aggregation sites. Chemical and behavioural analyses highlighted that long-chain hydrocarbons lead congeners towards aggregations and ensure the cohesion of the cluster. On the other hand, we investigated the influence of (1) the density of individuals and (2) the quality of available shelters on H. axyridis decision to settle and aggregate under shelters. A binary choice experiment conducted in laboratory highlighted a permanent aggregative behaviour of H. axyridis, even during non-wintering conditions, and the existence of social interactions between individuals. [less ▲]

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See detailImmobilized Staphylococcus lipase-catalysed synthesis of ricinoleic acid esters
Bouaziz, Ahlem ULg; Horchani, Habib; Gargouri, youssef et al

in Journal of Molecular Catalysis B : Enzymatic (2012), 75

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See detailPh Ib/II study of BKM120 plus trastuzumab in patients with trastuzumab-resistant HER2+ advanced breast cancer
Pistilli, Barbara; Urruticoechea, Ander; Chan Stephen et al

in Annals of Oncology (2012), 23(supplément 9), 116

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