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See detailMicrostructure analyses and thermoelectric properties of Ag1-xPb18Sb1+yTe20
Perlt, S.; Hoeche, Th; Dadda, J. et al

in Journal of Solid State Chemistry (2012), 193(SI), 58-63

This study reports microstructural investigations of long-term annealed 18, x=y=0, hereinafter referred to as AgPb18SbTe20) (Lead-Antimony-Silver-Tellurium, LAST-18) as well as of Ag1-xPb18Sb1+yTe20, i.e ... [more ▼]

This study reports microstructural investigations of long-term annealed 18, x=y=0, hereinafter referred to as AgPb18SbTe20) (Lead-Antimony-Silver-Tellurium, LAST-18) as well as of Ag1-xPb18Sb1+yTe20, i.e. Ag-deficient and Sb-excess LAST-18 (x not equal 0, y not equal 0), respectively. Two different length scales are explored. The micrometer scale was evaluated by SEM to analyze the volume fraction and the number of secondary phases as well as the impact of processing parameters on the homogeneity of bulk samples. For AgPb18SbTe20, site-specific FIB liftout of TEM lamellae from thermoelectrically characterized samples was accomplished to investigate the structure on the nanometer scale. High-resolution TEM and energy-filtered TEM were performed to reveal shape and size distribution of nanoprecipitates, respectively. A hypothesis concerning the structure-property relationship is set out within the frame of a gradient annealing experiment. This study is completed by results dealing with inhomogeneities on the micrometer scale of Ag1-xPb18Sb1+yTe20 and its electronic properties. (C) 2012 Elsevier Inc. All rights reserved. [less ▲]

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See detailMitochondrial transformation and in vitro DNA delivery
Remacle, Claire ULg; Hamel, Patrice; Larosa, Véronique ULg et al

in Bock, R; Knoop, V (Eds.) Genomics of Chloroplasts and Mitochondria (2012)

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See detailAdalimumab in ulcerative colitis: can pharmacodynamics be improved based on pharmacokinetics?
LOUIS, Edouard ULg; Panes, Julian

in Gastroenterology (2012), 142(1), 176-8

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See detailCircadian preference modulates the neural substrate of conflict processing across the day
Schmidt, Christina ULg; Peigneux, Philippe ULg; Leclercq, Yves ULg et al

in PLoS ONE (2012), 7(1), 29658

Human morning and evening chronotypes differ in their preferred timing for sleep and wakefulness, as well as in optimal daytime periods to cope with cognitive challenges. Recent evidence suggests that ... [more ▼]

Human morning and evening chronotypes differ in their preferred timing for sleep and wakefulness, as well as in optimal daytime periods to cope with cognitive challenges. Recent evidence suggests that these preferences are not a simple by-product of socio-professional timing constraints, but can be driven by inter-individual differences in the expression of circadian and homeostatic sleep-wake promoting signals. Chronotypes thus constitute a unique tool to access the interplay between those processes under normally entrained day-night conditions, and to investigate how they impinge onto higher cognitive control processes. Using functional magnetic resonance imaging (fMRI), we assessed the influence of chronotype and time-of-day on conflict processing-related cerebral activity throughout a normal waking day. Sixteen morning and 15 evening types were recorded at two individually adapted time points (1.5 versus 10.5 hours spent awake) while performing the Stroop paradigm. Results show that interference-related hemodynamic responses are maintained or even increased in evening types from the subjective morning to the subjective evening in a set of brain areas playing a pivotal role in successful inhibitory functioning, whereas they decreased in morning types under the same conditions. Furthermore, during the evening hours, activity in a posterior hypothalamic region putatively involved in sleep-wake regulation correlated in a chronotype-specific manner with slow wave activity at the beginning of the night, an index of accumulated homeostatic sleep pressure. These results shed light into the cerebral mechanisms underlying inter-individual differences of higher-order cognitive state maintenance under normally entrained day-night conditions. [less ▲]

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See detailcDNA-AFLP analysis of gene expression changes in apple trees induced by phytoplasma infection during compatible interaction
Aldaghi, Majid; Bertaccini, Assunta; Lepoivre, Philippe ULg

in European Journal of Plant Pathology (2012), 134

Abstract In order to gain insight into molecular and physiological changes in apple trees during compatible interaction with two ‘Candidatus Phytoplasma mali’ strains (AP and AT), cDNA-Amplified Fragment ... [more ▼]

Abstract In order to gain insight into molecular and physiological changes in apple trees during compatible interaction with two ‘Candidatus Phytoplasma mali’ strains (AP and AT), cDNA-Amplified Fragment Length Polymorphism (cDNA-AFLP) technique was used. A rootstock of apple (MM106) susceptible to ‘Ca. P. mali’ was used to extend the range of the potential host responses by the maximum number of identified genes that will be deregulated by phytoplasma in apple. Gene expression comparisons were studied in three directions: healthy versus infected samples, symptomatic versus nonsymptomatic sample, and AP-infected versus ATinfected sample. Forty-five genes whose steady-state levels of expression significantly changed in response to phytoplasma infection were identified. Among their partial cDNA sequences, only 27 showed similarity to DNA or protein data bases; of these, 18 were related to known genes in plants, and the rest were related to unknown or hypothetical proteins. Eighteen out of 45 did not show any similarity with sequences in data bases (potential novel genes). Quantitative real-time RT-PCR (qRT-PCR) was used to confirm differential expression of AFLP identified genes, and showed the similar profile expression for 11 known genes among 18, and for 13 unknown, hypothetical or novel genes among 27. Changes in gene expression involved a wide spectrum of biological functions, including processes of metabolism, cell defence, senescence, photosynthesis, transport, transcription, signal transduction and protein synthesis. This is the first study of global gene profiling in plants in response to phytoplasma infections using cDNA-AFLP, and a model is proposed to explain the mode of action of the ‘Ca. P. mali’ in apple. [less ▲]

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See detailContesting Co-inquiry: "Noncommunicative" Discourse in a Flemish Participatory Technology Assessment
Van Oudheusden, Michiel ULg; De Zutter, Hannes

in Science Communication (2012), 34(1), 83-113

This article explores how social scientists, ethicists, and nanotechnologists construct research decisions together, while engaged in a Flemish participatory technology assessment on nanotechnologies. It ... [more ▼]

This article explores how social scientists, ethicists, and nanotechnologists construct research decisions together, while engaged in a Flemish participatory technology assessment on nanotechnologies. It finds that they routinely probe one another to make substantive contributions but avoid the argumentative initiative itself through various discursive strategies, such as reversing roles and delegating responsibility. It argues that these strategies emanate through the project’s methodology of co-inquiry, which depends on sharing and partnership, whereas some members resist participating on initiators’ terms. It links such “noncommunicative” action to unresolved disagreements between participants about project ends, conflicting approaches to decision making, and divergent appreciations of “uncertainty.” [less ▲]

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See detailHeart rate and use of beta-blockers in stable outpatients with coronary artery disease.
Steg, Ph Gabriel; Ferrari, Roberto; Ford, Ian et al

in PLoS ONE (2012), 7(5), 36284

BACKGROUND: Heart rate (HR) is an emerging risk factor in coronary artery disease (CAD). However, there is little contemporary data regarding HR and the use of HR-lowering medications, particularly beta ... [more ▼]

BACKGROUND: Heart rate (HR) is an emerging risk factor in coronary artery disease (CAD). However, there is little contemporary data regarding HR and the use of HR-lowering medications, particularly beta-blockers, among patients with stable CAD in routine clinical practice. The goal of the present analysis was to describe HR in such patients, overall and in relation to beta-blocker use, and to describe the determinants of HR. METHODS AND FINDINGS: CLARIFY is an international, prospective, observational, longitudinal registry of outpatients with stable CAD, defined as prior myocardial infarction or revascularization procedure, evidence of coronary stenosis of >50%, or chest pain associated with proven myocardial ischemia. A total of 33,438 patients from 45 countries in Europe, the Americas, Africa, Middle East, and Asia/Pacific were enrolled between November 2009 and July 2010. Most of the 33,177 patients included in this analysis were men (77.5%). Mean (SD) age was 64.2 (10.5) years, HR by pulse was 68.3 (10.6) bpm, and by electrocardiogram was 67.2 (11.4) bpm. Overall, 44.0% had HR >/= 70 bpm. Beta-blockers were used in 75.1% of patients and another 14.4% had intolerance or contraindications to beta-blocker therapy. Among 24,910 patients on beta-blockers, 41.1% had HR >/= 70 bpm. HR >/= 70 bpm was independently associated with higher prevalence and severity of angina, more frequent evidence of myocardial ischemia, and lack of use of HR-lowering agents. CONCLUSIONS: Despite a high rate of use of beta-blockers, stable CAD patients often have resting HR >/= 70 bpm, which was associated with an overall worse health status, more frequent angina and ischemia. Further HR lowering is possible in many patients with CAD. Whether it will improve symptoms and outcomes is being tested. [less ▲]

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See detailEfficacy of powdered maize cobs against the maize weevil Sitophilus zeamais (Coleoptera: Curculionidae) in stored maize in Senegal
Gueye, Talla Momar; Cissokho, Papa Seyni; Goergen, Georg et al

in International Journal of Tropical Insect Science (2012)

Powdered maize cobs were tested as an alternative for pesticide use in stored maize. Five doses (2, 4, 6, 8 and 10 g/250 g seed) of powdered maize cobs applied at particle sizes of 1.4 and 0.4mm diameter ... [more ▼]

Powdered maize cobs were tested as an alternative for pesticide use in stored maize. Five doses (2, 4, 6, 8 and 10 g/250 g seed) of powdered maize cobs applied at particle sizes of 1.4 and 0.4mm diameter were compared with actellic powder against Sitophilus zeamais Motschulsky for 120 days. Mortality and survival data showed that cob powders did not act as fumigant but exerted a potent inhibition of progeny on direct contact with S. zeamais adults. The particle size of powdered cobs had no effect on maize damage and losses. At doses equal to or higher than 6 g powdered maize cobs/250 g grain maize, i.e. 2.4% (w/w), damage to grain was ,5% and weight losses ,1%. The protection offered at the highest dose was comparable to the pesticide control. The use of powdered maize cobs is discussed as a natural alternative to synthetic pesticides for protection of maize against S. zeamais. [less ▲]

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See detailDark Matter in a SUSY Left-Right Model
Vicente, Avelino ULg

in Journal of Physics: Conference Series (2012), 375

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See detailSur les traces des saints thébains en pays mosan
George, Philippe ULg

in Brocard, N.; Vannotti, Fr.; Wagner, A. (Eds.) Politique, société et construction identitaire : autour de saint Maurice (2012)

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See detailESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation.
Steg, Ph Gabriel; James, Stefan K.; Atar, Dan et al

in European Heart Journal (2012), 33(20), 2569-619

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See detailFaut-il operer les petits anevrysmes poplites asymptomatiques?
Holemans, Ch; VAN DAMME, Hendrik ULg; Defraigne, Jean-Olivier ULg

in Revue medicale de Liege (2012), 67(11), 576-81

The authors recently observed two patients who suffered acute lower limb ischemia secondary to thrombosis of a small (diameter of less than 2 cm) popliteal artery aneurysm. A literature search lead to the ... [more ▼]

The authors recently observed two patients who suffered acute lower limb ischemia secondary to thrombosis of a small (diameter of less than 2 cm) popliteal artery aneurysm. A literature search lead to the conclusion that small popliteal aneurysms, covered with mural thrombus and presenting a distorted neck due to elongation, are prone to thrombosis. Another risk factor is a restrained outflow bed as a result of previous micro-embolisations into the tibial arteries. The authors conclude that small popliteal artery aneurysms are not so innocent as is often presumed. [less ▲]

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See detailLes livres I et II des Annales : un tournant dans l’évolution du style de Tacite
Longrée, Dominique ULg

in Vita Latina (2012), 185-186

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See detailOverexpression of GRP94 in breast cancer cells resistant to oxidative stress promotes high levels of cancer cell proliferation and migration: implications for tumor recurrence.
Dejeans, Nicolas; Glorieux, Christophe; Guénin, Samuel ULg et al

in Free Radical Biology & Medicine (2012), 52(6), 993-1002

Targeting the altered redox status of cancer cells is emerging as an interesting approach to potentiate chemotherapy. However, to maximize the effectiveness of this strategy and define the correct ... [more ▼]

Targeting the altered redox status of cancer cells is emerging as an interesting approach to potentiate chemotherapy. However, to maximize the effectiveness of this strategy and define the correct chemotherapeutic associations, it is important to understand the biological consequences of chronically exposing cancer cells to reactive oxygen species (ROS). Using an H(2)O(2)-generating system, we selected a ROS-resistant MCF-7 breast cancer cell line, namely Resox cells. By exploring different survival pathways that are usually induced during oxidative stress, we identified a constitutive overexpression of the endoplasmic reticulum chaperone, GRP94, in these cells, whereas levels of its cytoplasmic homolog HSP90, or GRP78, were not modified. This overexpression was not mediated by constitutive unfolded protein response (UPR) activation. The increase in GRP94 is tightly linked to an increase in cell proliferation and migration capacities, as shown by GRP94-silencing experiments. Interestingly, we also observed that GRP94 silencing inhibits migration and proliferation of the highly aggressive MDA-MB-231 cells. By immunohistochemistry, we showed that GRP94 expression was higher in recurrent human breast cancers than in their paired primary neoplasias. Similar to the situation in the Resox cells, this increase was not associated with an increase in UPR activation in recurrent tumors. In conclusion, this study suggests that GRP94 overexpression may be a hallmark of aggressiveness and recurrence in breast cancers. [less ▲]

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See detailToll- and NOD-like receptor mRNA expression in canine sino-nasal aspergillosis and idiopathic lymphoplasmacytic rhinitis
Mercier, Elise ULg; Peters, Iain; Clercx, Cécile ULg et al

in Veterinary Immunology and Immunopathology (2012), 145(3-4), 618-624

The pathogenesis of canine sino-nasal aspergillosis (SNA) and lymphoplasmacytic rhinitis (LPR) remains poorly understood. The innate immune system is implicated in the etiology of human chronic ... [more ▼]

The pathogenesis of canine sino-nasal aspergillosis (SNA) and lymphoplasmacytic rhinitis (LPR) remains poorly understood. The innate immune system is implicated in the etiology of human chronic rhinosinusitis. Therefore, we hypothesized that dysfunction in innate immunity could be implicated in the pathogenesis of SNA and LPR. Expression of messenger RNA (mRNA) encoding Toll-like receptors (TLRs) 1 to 10 and NOD-like receptors (NODs) 1 and 2 in nasal mucosal biopsies from SNA or LPR dogs was compared with mucosa from healthy controls. Gene expression was quantified using quantitative real-time reverse transcriptase polymerase chain reaction normalized against multiple housekeeper genes. All TLR and NOD genes were quantified in all samples. SNA was associated with significantly increased expression of TLRs 1, 2, 3, 4, 6, 7, 8, 9 and 10; and NOD2, relative to controls. LPR was associated with significantly increased expression of TLRs 1, 2, 6, 7 and 8, relative to controls. There was significantly more expression of TLRs 1, 4, 6, 7, 8, 9, 10 and NOD2 in SNA dogs than in LPR dogs. The significance of these differences in the pathogenesis of these diseases is yet to be determined. [less ▲]

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See detailA Remote Sensing Based Calibration Framework for the MOLAND Urban Growth Model of Dublin
Van de Voorde, Tim; van der Kwast, Johannes; Canters, Frank et al

in International Journal of Agricultural and Environmental Information Systems (2012), 3(2), 1-21

Land-use change models are useful tools for assessing and comparing the environmental impact of alternative policy scenarios. Their increasing popularity as spatial planning instruments also poses new ... [more ▼]

Land-use change models are useful tools for assessing and comparing the environmental impact of alternative policy scenarios. Their increasing popularity as spatial planning instruments also poses new scientific challenges, such as correctly calibrating the model. The challenge in model calibration is twofold: obtaining a reliable and consistent time series of land-use information and finding suitable measures to compare model output to reality. Both of these issues are addressed in this paper. The authors propose a model calibration framework that is supported by information on urban form and function derived from medium-resolution remote sensing data through newly developed spatial metrics. The remote sensing derived maps are compared to model output of the same date for two model scenarios using well-known spatial metrics. Results demonstrate a good resemblance between the simulation output and the remote sensing derived maps. [less ▲]

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See detailUne endocardite infectieuse compliquee: diagnostic, traitement et prophylaxie.
Paris, Catherine ULg; Pierard, Luc ULg

in Revue medicale de Liege (2012), 67(7-8), 398-402

The case of a 60-year-old male presenting fever of recent onset is reported. He had undergone a Bentall operation seven yeasr previously. An infective endocarditis caused by Entercoccus Faecalis was ... [more ▼]

The case of a 60-year-old male presenting fever of recent onset is reported. He had undergone a Bentall operation seven yeasr previously. An infective endocarditis caused by Entercoccus Faecalis was detected on his prosthetic valve. After a favorable evolution under antibiotic treatment, the patient developed a perivalvular abscess requiring surgical treatment. The patient's evolution was satisfactory. Diagnosis, with the specific role of echocardiography; treatment, with a recall of surgical indications; particularities of the specific complication and prevention of this pathology are discussed. [less ▲]

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See detailPh Ib/II study of BKM120 plus trastuzumab in patients with trastuzumab-resistant HER2+ advanced breast cancer
Pistilli, Barbara; Urruticoechea, Ander; Chan Stephen et al

in Annals of Oncology (2012), 23(supplément 9), 116

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