References of "2012"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailDifferential Effects of Cocaine on Dopamine Neuron Firing in Awake and Anesthetized Rats
Koulchitsky, Stanislav ULg; DE BACKER, Benjamin ULg; Quertemont, Etienne ULg et al

in Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology (2012), 37

Cocaine (benzoylmethylecgonine), a natural alkaloid, is a powerful psychostimulant and a highly addictive drug. Unfortunately, the relationships between its behavioral and electrophysiological effects are ... [more ▼]

Cocaine (benzoylmethylecgonine), a natural alkaloid, is a powerful psychostimulant and a highly addictive drug. Unfortunately, the relationships between its behavioral and electrophysiological effects are not clear. We investigated the effects of cocaine on the firing of midbrain dopaminergic (DA) neurons, both in anesthetized and awake rats, using pre-implanted multielectrode arrays and a recently developed telemetric recording system. In anesthetized animals, cocaine (10 mg/kg, intraperitoneally) produced a general decrease of the firing rate and bursting of DA neurons, sometimes preceded by a transient increase in both parameters, as previously reported by others. In awake rats, however, injection of cocaine led to a very different pattern of changes in firing. A decrease in firing rate and bursting was observed in only 14% of DA neurons. Most of the other DA neurons underwent increases in firing rate and bursting: these changes were correlated with locomotor activity in 52% of the neurons, but were uncorrelated in 29% of them. Drug concentration measurements indicated that the observed differences between the two conditions did not have a pharmacokinetic origin. Taken together, our results demonstrate that cocaine injection differentially affects the electrical activity of DA neurons in awake and anesthetized states. The observed increases in neuronal activity may in part reflect the cocaine-induced synaptic potentiation found ex vivo in these neurons. Our observations also show that electrophysiological recordings in awake animals can uncover drug effects, which are masked by general anesthesia. [less ▲]

Detailed reference viewed: 42 (12 ULg)
Full Text
Peer Reviewed
See detailPurification, refolding and characterization of the trimeric Omp2a outer membrane porin from Brucella melitensis.
Roussel, G; Matagne, André ULg; De Bolle, X et al

in Protein Expression & Purification (2012), 83(2), 198-204

Brucella melitensis is a gram-negative bacteria known to cause brucellosis and to produce severe infections in humans. Whilst brucella's outer membrane proteins have been extensively studied due to their ... [more ▼]

Brucella melitensis is a gram-negative bacteria known to cause brucellosis and to produce severe infections in humans. Whilst brucella's outer membrane proteins have been extensively studied due to their potential role as antigens or virulence factors, their function is still poorly understood at the structural level, as the 3D structure of Brucella beta-barrel membrane proteins are still unknown. In this context, the B. melitensis trimeric Omp2a porin has been overexpressed and refolded in n-dodecyl-beta-d-maltopyranoside. We here show that this refolding process is insensitive to urea but is temperature- and ionic strength-dependent. Reassembled species were characterized by fluorescence, size-exclusion chromatography and circular dichroism. A refolding mechanism is proposed, suggesting that Omp2a first refolds under a monomeric form and then self-associates into a trimeric state. This first complete in vitro refolding of a membrane protein from B. melitensis shall eventually lead to functional and 3D structure determination. [less ▲]

Detailed reference viewed: 20 (0 ULg)
Full Text
Peer Reviewed
See detailSmouldering malignant melanoma and metastatic dormancy: an update and review.
PIERARD, Gérald ULg; PIERARD-FRANCHIMONT, Claudine ULg; REGINSTER, Marie-Annick ULg et al

in Dermatology Research and Practice (2012), 2012

The fund of knowledge regarding the versatility of presentation of MM metastases is still quite incomplete. The recent literature pertaining to the current understanding of the mechanisms underlying two ... [more ▼]

The fund of knowledge regarding the versatility of presentation of MM metastases is still quite incomplete. The recent literature pertaining to the current understanding of the mechanisms underlying two special features of MM metastasis is reviewed. On the one hand, a long disease-free interval (MM dormancy) may occur before the surge of overt metastases. On the other hand, the so-called MM smouldering phenomenon refers to the condition where regional metastases wax and wane for long periods of time on restricted skin regions. It is important to emphasize that local micrometastases often predict sentinel lymph node involvement but may not reflect progression of the primary MM to full-blown visceral metastatic competence. It is likely that a combination of factors impacts the versatile MM metastasic progression. Among the main factors, one has to mention the phenotypic heterogeneity and variability in the phenotype of MM cells, the presence of MM stem cells and MM cells engaged in an amplification proliferation pool, as well as the host immune response, and possibly the induction of a particular stromal structure and vascularity. [less ▲]

Detailed reference viewed: 19 (5 ULg)
Peer Reviewed
See detailAlimentation de l’enfant
de Suremain, Charles-Edouard; Razy, Elodie ULg

in Poulain, Jean-Pierre (Ed.) Dictionnaire des cultures et des modèles alimentaires (2012)

Detailed reference viewed: 20 (3 ULg)
Full Text
Peer Reviewed
See detailNanosphere Lithography and Hydrothermal Growth : How to Increase Surface Area and Control Reversible Wetting Properties of ZnO Nanowire Arrays ?
Colson, Pierre ULg; Schrijnemakers, Audrey ULg; Vertruyen, Bénédicte ULg et al

in Journal of Materials Chemistry (2012), 22(33), 17086-17093

Due to their large surface-area-to-volume ratio as well as their interesting intrinsic optical and electronic properties, ZnO 1D nanostructures are part of the few dominant materials for nanotechnology ... [more ▼]

Due to their large surface-area-to-volume ratio as well as their interesting intrinsic optical and electronic properties, ZnO 1D nanostructures are part of the few dominant materials for nanotechnology. In this article, we compare two different routes of using the nanosphere lithography for the manufacturing of well-aligned, density-controlled ZnO nanowires by low-temperature hydrothermal growth. The first route uses the colloidal mask as a template for the patterned growth of the nanowires, while in the second route, the nanospheres act as a mask to pattern the seed layer. SEM and XRD characterizations are performed on samples manufactured by both routes and evidence patterned well-aligned nanowires with high c-axis texturing in the first synthetic route. Oriented growth is less pronounced in the second route, as well as the ability to adsorb dye. However, for the first route the dye loading measurements reveal that the amount of N-719 adsorbed is higher than on unpatterned ZnO nanowires films, highlighting an increased interface area. Reversible hydrophobicity to superhydrophilicity transition was observed and intelligently controlled by alternation of UV illumination and dark storage. This promising synthetic route opens exciting perspectives for the production of ZnO nanowire arrays with tunable density, wetting properties and enhanced adsorption properties. [less ▲]

Detailed reference viewed: 67 (28 ULg)
Full Text
Peer Reviewed
See detailImpairment of assets (IAS 36), a consistent application, to what extent?
Yammine, Mira ULg

Conference (2012)

The objective of this paper is to determine whether the application of impairment of assets -IAS 36- is consistent among companies and countries. The study covers 302 companies in 16 countries which ... [more ▼]

The objective of this paper is to determine whether the application of impairment of assets -IAS 36- is consistent among companies and countries. The study covers 302 companies in 16 countries which mandate the application of IFRS for listed and consolidated companies. A descriptive analysis was performed on information obtained from financial statements for the reporting year 2008. This same information was used for linear and logistic regressions that were conducted on a number of variables that are determined from the literature to have an impact on the impairment recognition and magnitude. Some of these variables such as return, market to book ratio and leverage were found to have an impact on the impairment decision and magnitude. The impact of these variables was different whether we consider all countries pooled together or whether we put European and Non-European countries in separate groups. If we go further and treat each country individually, when enough companies are available, we notice that the impact of these variables still is different. In addition, the study showed differences in percentage of non-explained variables embedded in the residuals obtained from the regressions performed on individual and grouped countries. These differences are an indication of the presence of factors that affect the consistent application of IFRS. Some of these factors are difference in interpretation, influence of domestic accounting standards, culture and enforcement bodies. [less ▲]

Detailed reference viewed: 4 (1 ULg)
Full Text
Peer Reviewed
See detailTowards a “concurrent design facility (CDF)” for nanosatellites: a back-of-the-envelope calculation of the overall energy budget of OUFTI-1
Denis, Amandine ULg; Crosset, Nicolas ULg; Pisane, Jonathan ULg et al

Conference (2012)

We give a very compact account of the overall energy budget of the OUFTI-1 nanosatellite, thereby providing a useful guide for future designs, as well as an explanation of why a nanosatellite can ... [more ▼]

We give a very compact account of the overall energy budget of the OUFTI-1 nanosatellite, thereby providing a useful guide for future designs, as well as an explanation of why a nanosatellite can, energetically, survive and do useful tasks in space. [less ▲]

Detailed reference viewed: 21 (2 ULg)
See detailEndocrine factors and AMPKα1 are involved in the spread of hatch and subsequent neonatal performance of broiler chicks
Wang, Yufeng; Li, Yue; Willems, Els et al

Poster (2012)

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailMechanisms of skin adherence and invasion by dermatophytes
Baldo, Aline ULg; Monod, M.; Mathy, Anne ULg et al

in Mycoses (2012), 55(3), 218-223

Detailed reference viewed: 35 (13 ULg)
See detailEffect of maternal transition of long chain PUFA’s on fertility, hatchability, embryonic mortality, chick quality, and performance of the progeny
Koppenol, Astrid; Delezie, Evelyne; Willems, Els et al

in Proceedings of the Meditarranean Poultry Summit of WPSA and 6th Internation Poultry Conference (2012)

Detailed reference viewed: 10 (0 ULg)
Full Text
See detailPaléontologie - partim. Paléozoologie (Notes de travaux pratiques - 2012)
Denayer, Julien ULg

Learning material (2012)

Detailed reference viewed: 190 (8 ULg)
Full Text
Peer Reviewed
See detailA short introduction into Bayesian evaluation of informative hypotheses as an alternative to exploratory comparisons of multiple group means
Béland, Sébastien; Klugkist, Irène; Raîche, Gilles et al

in Tutorials in Quantitative Methods for Psychology (2012), 8

This paper presents an introduction into Bayesian evaluation of informative hypotheses, that is, hypotheses representing explicit expectations about multiple group means (Hoijtink, 2011; Hoijtink ... [more ▼]

This paper presents an introduction into Bayesian evaluation of informative hypotheses, that is, hypotheses representing explicit expectations about multiple group means (Hoijtink, 2011; Hoijtink, Klugkist & Boelen, 2008). The authors begin by discussing some limits of exploratory methods before presenting a non-technical overview of the Bayesian approach. References are provided for the technical details. A particular effort is made to illustrate the method with an example from psychology. References to software, more elaborate textbooks and tutorials enable researchers to apply this novel method to their own data. [less ▲]

Detailed reference viewed: 16 (2 ULg)
Full Text
Peer Reviewed
See detailRemoving the North Pacific halocline: effects on global climate, ocean circulation and the carbon cycle
Menviel, L.; Timmermann, A.; Timm, O. et al

in Deep-Sea Research Part II, Topical Studies in Oceanography (2012), 61-64

Detailed reference viewed: 24 (3 ULg)
Full Text
See detailMonographing "Sacred Laws"
Carbon, Jan-Mathieu ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (2012), 25

Detailed reference viewed: 13 (0 ULg)
Full Text
Peer Reviewed
See detailNoncollinear magnetism and single-ion anisotropy in multiferroic perovskites
Weingart, C.; Spaldin, N.; Bousquet, Eric ULg

in Physical Review. B, Condensed Matter and Materials Physics (2012), 86(9),

The link between the crystal distortions of the perovskite structure and the magnetic exchange interaction, the single-ion anisotropy (SIA), and the Dzyaloshinsky-Moriya (DM) interaction are investigated ... [more ▼]

The link between the crystal distortions of the perovskite structure and the magnetic exchange interaction, the single-ion anisotropy (SIA), and the Dzyaloshinsky-Moriya (DM) interaction are investigated by means of density functional calculations. Using BiFeO 3 and LaFeO 3 as model systems, we quantify the relationship between the oxygen octahedra rotations, the ferroelectricity, and the weak ferromagnetism (wFM). We recover the fact that the wFM is due to the DM interaction induced by the oxygen octahedra rotations. We find a simple relationship between the wFM, the oxygen rotation amplitude, and the ratio between the DM vector and the exchange parameter such that the wFM increases with the oxygen octahedra rotation when the SIA does not compete with the DM forces induced on the spins. Unexpectedly, we also find that in spite of the d5 electronic configuration of Fe3 +, the SIA is very large in some structures and is surprisingly strongly sensitive to the chemistry of the A-site cation of the ABO 3 perovskite. In the ground R3c state phase we show that the SIA shape induced by the ferroelectricity and the oxygen octahedra rotations are in competition such that it is possible to turn the wFM "on" and "off" through the relative size of the two types of distortion. © 2012 American Physical Society. [less ▲]

Detailed reference viewed: 15 (2 ULg)
Full Text
Peer Reviewed
See detailRecension de l'ouvrage de M. IACUB, "Une société de violeurs?" (Paris, Fayard, 2012)
Thirion, Nicolas ULg

in Journal des Tribunaux (2012)

Detailed reference viewed: 84 (19 ULg)
See detailContribution au développement d’un procédé industriel de revêtement d’acier
Amoura, Makhlouf; Heinrichs, Benoît ULg

Report (2012)

Detailed reference viewed: 18 (0 ULg)
Full Text
Peer Reviewed
See detailUn passage de l'Évangile selon Matthieu illustré : O.Moen inv. 631
Carlig, Nathan ULg

in Chronique d'Egypte : Bulletin Périodique de la Fondation Egyptologique Reine Elisabeth (2012), 87(174), 383-390

Édité par P.J. Sijpesteijn en 1984, l'O.Moen inv. 631 (MP³ 2699.5 = LDAB 2954 = TM 61800 ; Ve/VIe siècles, provenance inconnue, 10,4 cm x 11,5 cm) conserve 4 lignes de l'Évangile selon Matthieu, 1, 19-20 ... [more ▼]

Édité par P.J. Sijpesteijn en 1984, l'O.Moen inv. 631 (MP³ 2699.5 = LDAB 2954 = TM 61800 ; Ve/VIe siècles, provenance inconnue, 10,4 cm x 11,5 cm) conserve 4 lignes de l'Évangile selon Matthieu, 1, 19-20, qui relatent le premier songe de Joseph, suivies de 4 dessins non élucidés à ce jour. Parallèles papyrologiques et archéologiques à l'appui, l'auteur propose d'identifier les deux personnages représentés à Joseph et à l'ange, ce qui ferait de l'ostracon un des témoignages iconographiques les plus anciens de cette scène, et le seul attesté dans la documentation papyrologique. [less ▲]

Detailed reference viewed: 29 (7 ULg)
See detailIGCP 580, Magnetic Susceptibility and Gamma-Ray Spectrometry through time. Abstracts book IGCP-580, 4th annual meeting, 24-30th June 2012, Graz, Austria
Kido; Suttner; Piller et al

Book published by Berichte des Institutes für Erdwissenschaften, Karl-Franzens-Universität Graz (2012)

Detailed reference viewed: 15 (0 ULg)
Full Text
Peer Reviewed
See detailHow do temperate bryophytes face the challenge of a changing environment? Lessons from the past and predictions for the future
Desamore, Aurélie ULg; Laenen, Benjamin ULg; Stech, M. B et al

in Global Change Biology (2012), 18(9), 2915-2924

Bryophytes are a group of early land plants, whose specific ecophysiological and biological features, including poikilohydry, sensitivity to moderately high temperature and high dispersal ability, make ... [more ▼]

Bryophytes are a group of early land plants, whose specific ecophysiological and biological features, including poikilohydry, sensitivity to moderately high temperature and high dispersal ability, make them ideal candidates for investigating the impact of climate changes. Employing a combined approach of species distribution modelling (SDM) and molecular phylogeography in the temperate moss Homalothecium sericeum, we explore the significance of the Mediterranean refugia, contrasting the southern and northern refugia hypotheses, determine the extent to which recolonization of previously glaciated areas has been facilitated by the high dispersal ability of the species and make predictions on the extent to which it will be impacted by ongoing climate change. The Mediterranean areas exhibit the highest nucleotidic diversities and host a mixture of ancestral, endemic and more recently derived haplotypes. Extra-Mediterranean areas exhibit low genetic diversities and Euro-Siberian populations display a significant signal of expansion that is identified to be of Euro-Siberian origin, pointing to the northern refugia hypothesis. The SDMs predict a global net increase in range size owing to ongoing climate change, but substantial range reductions in southern areas. Presence of a significant phylogeographical signal at different spatial scales suggests, however, that dispersal limitations might constitute, as opposed to the traditional view of spore-producing plants as efficient dispersers, a constraint for migration. This casts doubts about the ability of the species to face the massive extinctions predicted in the southern areas, threatening their status of reservoir of genetic diversity. © 2012 Blackwell Publishing Ltd. [less ▲]

Detailed reference viewed: 30 (3 ULg)