References of "2012"
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See detailL'asthme: une maladie complexe mettant en jeu facteurs environnementaux et terrain genetique.
LOUIS, Renaud ULg; SCHLEICH, FLorence ULg; Corhay, Jean-Louis ULg et al

in Revue Médicale de Liège (2012), 67(5-6), 286-91

Asthma is a complex disease highly dependent of environmental exposure and genetic background. Through linkage analysis, positional cloning and genome wide association studies, novel asthma genes have ... [more ▼]

Asthma is a complex disease highly dependent of environmental exposure and genetic background. Through linkage analysis, positional cloning and genome wide association studies, novel asthma genes have come out such as ADAM-33 or ORMLD3. Important environmental factors include allergenic exposure, pollutants and especially particulate matters, tobacco, aerosol exposure, viral infections and level of exposure to endotoxin. The effects of environmental factors are modulated by the genetic sequence and numerous single nucleotide polymorphisms (SNPs). Recently, it has also become clear that environmental factors may alter gene expression by DNA methylation or histone methylation/acetylation without changing the gene sequence and thereby changing asthmatic phenotype. [less ▲]

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See detailRecommandations Europeennes 2011 pour la prise en charge des maladies cardiovasculaires pendant la grossesse. Partie 2: Prise en charge de l'hypertension arterielle.
Moonen, Marie ULg; Legrand, D.; LANCELLOTTI, Patrizio ULg

in Revue Médicale de Liège (2012), 67(10), 509-12

In this article, we report the 2011 European guidelines on the management of cardiovascular diseases during pregnancy, with particular attention to the management of hypertension as hypertensive disorders ... [more ▼]

In this article, we report the 2011 European guidelines on the management of cardiovascular diseases during pregnancy, with particular attention to the management of hypertension as hypertensive disorders are the most frequent cardiovascular complications in pregnancy. [less ▲]

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See detailNeuropsychiatric Inventory data in a Belgian sample of elderly persons with and without dementia
Squelard, Gilles ULg; Missotten, Pierre ULg; Paquay, Louis et al

in Clinical Interventions in Aging (2012), 2(7), 423-430

Background/aims: This study assesses and compares prevalence of psychological and behavioral symptoms in a Belgian sample of people with and without dementia. Methods: A total of 228 persons older than 65 ... [more ▼]

Background/aims: This study assesses and compares prevalence of psychological and behavioral symptoms in a Belgian sample of people with and without dementia. Methods: A total of 228 persons older than 65 years with dementia and a group of 64 non- demented persons were assessed using the Neuropsychiatric Inventory (NPI) in 2004. Results: Within the group without dementia, the most frequent symptoms were depression, agitation, and irritability. Within the group with dementia, the most common symptoms were depression, irritability, apathy, and agitation. Prevalence of delusions (P [less ▲]

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See detailChirurgie metabolique: une place croissante dans le traitement du diabete.
De Flines, J.; Franck, M.; Rorive, M. et al

in Revue Médicale Suisse (2012), 8(351), 1621-41626-7

Bariatric surgery becomes more and more important in the management of the obese patient with type 2 diabetes, especially in case of failure of medical approaches. Metabolic improvement results not only ... [more ▼]

Bariatric surgery becomes more and more important in the management of the obese patient with type 2 diabetes, especially in case of failure of medical approaches. Metabolic improvement results not only from weight loss and the subsequent reduction in insulin resistance, but also from modifications of digestive hormones (especially incretins) that contribute to promote insulin secretion. This new paradigm, moving from bariatric surgery to metabolic surgery, opens new perspectives. The present article briefly describes innovative surgical techniques focusing on endocrine and metabolic improvement rather than on weight loss, the preliminary results of metabolic surgery in patients with type 2 diabetes and a body mass index <35 kg/m2 and, finally, some data regarding the surgical management of obese patients with type I diabetes not well treated with classical medical means. [less ▲]

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See detailMethod for the preliminary design of Piano Key Weirs
Machiels, Olivier ULg; Erpicum, Sébastien ULg; Archambeau, Pierre ULg et al

in Houille Blanche (2012), 4

The Piano Key Weir (PKW) is a particular geometry of weir associating to a labyrinth shape the use of overhangs to reduce the basis length. The PKW could thus be directly placed on a dam crest. Together ... [more ▼]

The Piano Key Weir (PKW) is a particular geometry of weir associating to a labyrinth shape the use of overhangs to reduce the basis length. The PKW could thus be directly placed on a dam crest. Together with its important discharge capacity for low heads, this geometric feature makes the PKW an interesting solution for dam rehabilitation. However, its hydraulic design remains problematic, even at a preliminary stage. This paper presents a preliminary design method based on results of experimental tests. The method enables to design project models by extrapolation of characteristics of existing idealized scale models. A practical application is presented to illustrate the method. [less ▲]

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See detailNeural correlates of hypokinetic gait in Parkinson’s disease: An fMRI study
Cremers, Julien ULg; Stamatakis, Julien; D'Ostilio, Kevin ULg et al

Poster (2012)

Objective: To investigate the neural correlates of hypokinetic gait in Parkinson’s disease (PD) using functional magnetic resonance imaging (fMRI). Background: Although hypokinetic gait is frequent and ... [more ▼]

Objective: To investigate the neural correlates of hypokinetic gait in Parkinson’s disease (PD) using functional magnetic resonance imaging (fMRI). Background: Although hypokinetic gait is frequent and has a negative impact on quality of life in PD, its underlying mechanisms remain poorly understood. Assuming that the brain regions recruited during real and imagined gait strongly overlap, mental imagery of brisk gait may be a successful approach to study hypokinetic gait in PD. Methods: Fifteen ‘‘on-drugs’’ PD patients (8 males; mean age 5 65.1 6 9.4 years) and fifteen controls matched for age, gender and mental imagery skills were trained to perform video-taped trials of comfortable and brisk gait on a 25 meter-path. The study was organ- ized as a block-design fMRI experiment where subjects were instructed to rehearse themselves performing comfortable and brisk gait and to press a key to indicate when they completed each 25 meter-imagined gait trial. The imagined speed reserve (ISR) defined as the difference between imagined brisk and comfortable gait speeds was measured as a control of behavioral performance. Imaging data processing and analyses were performed using SPM8. The first-level individual contrast images representing the comparison between brisk and comfortable gait were entered as two separate groups (controls vs patients) in an ANOVA with the corresponding ISRs as correlation regressors. Results: Compared with controls, patients showed hypokinetic gait during real gait training as their increase in speed during brisk relatively to comfortable gait was related to an increase in step ca- dence (r50.87; p<0.001) but not in step length (r50.11). ISRs meas- ured during fMRI and their real counterparts measured offline strongly correlated in patients (r50.88; p<0.001) and controls (r50.59; p50.02). Between-group comparison (p<0.001, uncorrected) of fMRI data showed that increasing imagined gait speed was strongly associated with increased activity of the left posterior parietal cortex in controls and with decreased activity of this region in patients. Conclusions: Our findings suggest that hypokinetic gait in PD is related to the impaired functioning of the left posterior parietal cortex. This area may represent a target for therapeutic interventions aimed at alleviating gait disturbances in PD. [less ▲]

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See detailRobust transformation procedure for the production of transgenic farmer-preferred cassava landraces.
Zainuddin, Ima M.; Schlegel, Kim; Gruissem, Wilhelm et al

in Plant methods (2012), 8(1), 24

Recent progress in cassava transformation has allowed the robust production of transgenic cassava even under suboptimal plant tissue culture conditions. The transformation protocol has so far been used ... [more ▼]

Recent progress in cassava transformation has allowed the robust production of transgenic cassava even under suboptimal plant tissue culture conditions. The transformation protocol has so far been used mostly for the cassava model cultivar 60444 because of its good regeneration capacity of embryogenic tissues. However, for deployment and adoption of transgenic cassava in the field it is important to develop robust transformation methods for farmer- and industry-preferred landraces and cultivars. Because dynamics of multiplication and regeneration of embryogenic tissues differ between cassava genotypes, it was necessary to adapt the efficient cv. 60444 transformation protocol to genotypes that are more recalcitrant to transformation. Here we demonstrate that an improved cassava transformation protocol for cv. 60444 could be successfully modified for production of transgenic farmer-preferred cassava landraces. The modified transformation method reports on procedures for optimization and is likely transferable to other cassava genotypes reportedly recalcitrant to transformation provided production of high quality FEC. Because the three farmer-preferred cassava landraces selected in this study have been identified as resistant or tolerant to cassava mosaic disease (CMD), the adapted protocol will be essential to mobilize improved traits into cassava genotypes suitable for regions where CMD limits production. [less ▲]

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See detailPrevalence and management of cancer-related anaemia, iron deficiency and the specific role of intravenous iron
Aapro, M.; Osterborg, A.; Gascon, P. et al

in Annals of Oncology (2012), 23

Background: Chronic diseases reduce the availability of iron for effective erythropoiesis. This review summarises clinical consequences of iron deficiency (ID) and anaemia in cancer patients, mechanisms ... [more ▼]

Background: Chronic diseases reduce the availability of iron for effective erythropoiesis. This review summarises clinical consequences of iron deficiency (ID) and anaemia in cancer patients, mechanisms how impaired iron homeostasis affects diagnosis and treatment of ID, and data from clinical trials evaluating i.v. iron with or without concomitant erythropoiesis-stimulating agents (ESAs). Design: Clinical trial reports were identified in PubMed and abstracts at relevant major congresses. Results: Reported prevalence of ID in cancer patients ranges from 32 to 60% and most iron-deficient patients are also anaemic. Randomised clinical trials have shown superior efficacy of i.v. iron over oral or no iron in reducing blood transfusions, increasing haemoglobin, and improving quality of life in ESA-treated anaemic cancer patients. Furthermore, i.v. iron without additional ESA should be evaluated as potential treatment in patients with chemotherapyinduced anaemia. At recommended doses, i.v. iron is well tolerated, particularly compared with oral iron. No serious drug-related adverse effects were seen during long-term use in renal disease and no effect on tumour growth has been observed in trials with anaemic cancer patients. Conclusions: Reliable diagnosis and treatment of ID are recommended key steps in modern cancer patient management to minimise impact on quality of life and performance status. [less ▲]

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See detailLes organisations d'aide et soins à domicile: des entreprises à haute valeur ajoutée
Defourny, Jacques ULg

in La Revue de l'Aide et des Soins à Domicile (2012), 131(mai-juillet), 24-27

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See detailAttention Supports Verbal Short-Term Memory via Competition between Dorsal and Ventral Attention Networks.
Majerus, Steve ULg; Attout, Lucie ULg; D'Argembeau, Arnaud ULg et al

in Cerebral Cortex (2012), 22

Interactions between the neural correlates of short-term memory (STM) and attention have been actively studied in the visual STM domain but much less in the verbal STM domain. Here we show that the same ... [more ▼]

Interactions between the neural correlates of short-term memory (STM) and attention have been actively studied in the visual STM domain but much less in the verbal STM domain. Here we show that the same attention mechanisms that have been shown to shape the neural networks of visual STM also shape those of verbal STM. Based on previous research in visual STM, we contrasted the involvement of a dorsal attention network centered on the intraparietal sulcus supporting task-related attention and a ventral attention network centered on the temporoparietal junction supporting stimulus-related attention. We observed that, with increasing STM load, the dorsal attention network was activated while the ventral attention network was deactivated, especially during early maintenance. Importantly, activation in the ventral attention network increased in response to task-irrelevant stimuli briefly presented during the maintenance phase of the STM trials but only during low-load STM conditions, which were associated with the lowest levels of activity in the dorsal attention network during encoding and early maintenance. By demonstrating a trade-off between task-related and stimulus-related attention networks during verbal STM, this study highlights the dynamics of attentional processes involved in verbal STM. [less ▲]

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See detailNécrologie Jacques Stiennon (1920-2012)
George, Philippe ULg

in Cahiers de Civilisation Médiévale (2012), 55

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See detailErrors in 2-D modelling using a 0th order turbulence closure for compound channel flows
Linde, F.; Paquier, A.; Proust, S. et al

in International Conference on Fluvial Hydraulics, River Flow 2012 (2012)

When dealing with flood issues, compound channels flows are often encountered in the field. This paper investigates the errors that can be expected when using 2-D modelling for compound channel flows ... [more ▼]

When dealing with flood issues, compound channels flows are often encountered in the field. This paper investigates the errors that can be expected when using 2-D modelling for compound channel flows, comparing the simulations with experiments. Three flow configurations are analyzed: uniform, gradually varied and rapidly varied flows. The last configuration is obtained by setting a transverse embankment on the flood plain. Errors are estimated on the sub-section mean velocity, discharge andwater depth, on the mixing layer width and on the depth-averaged stream-wise velocity and lateral shear stress. Depending on the flow configuration and on the studied parameter, relative errors significantly vary from nearly zero to 50%. The influence of the 0th order turbulence closure on the mean flow and the dimensions of the recirculation zone behind the embankment is also investigated, using either constant eddy viscosity or Elder's model. © 2012 Taylor & Francis Group, London. [less ▲]

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See detailAutomatic Aircraft Load Planning
Limbourg, Sabine ULg; Schyns, Michael ULg; Laporte, Gilbert

in Journal of the Operational Research Society (2012), 63

The goal of this paper is the development of a new mixed integer linear program designed for optimally loading a set of containers and pallets into a compartmentalised cargo aircraft. It is based on real ... [more ▼]

The goal of this paper is the development of a new mixed integer linear program designed for optimally loading a set of containers and pallets into a compartmentalised cargo aircraft. It is based on real-world problems submitted by a professional partner. This model takes into account strict technical and safety constraints. In addition to the standard goal of optimally positioning the centre of gravity, we also propose a new approach based on the moment of inertia. This double goal implies an increase in aircraft efficiency and a decrease in fuel consumption. Cargo loading generally remains a manual, or at best a computer assisted, and time consuming task. A fully automatic software was developed to quickly compute optimal solutions. Experimental results show that our approach achieves better solutions than manual planning, within only a few seconds. [less ▲]

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See detailAdiabatic Solar-Like Oscillations in Red Giant Stars
Montalban Iglesias, Josefa ULg; Miglio, Andrea; Noels-Grötsch, Arlette ULg et al

in Red Giants as Probes of the Structure and Evolution of the Milky Way (2012)

Since the detection of non-radial solar-like oscillation modes in red giants with the CoRoT satellite, the interest in the asteroseismic properties of red giants and the link with their global properties ... [more ▼]

Since the detection of non-radial solar-like oscillation modes in red giants with the CoRoT satellite, the interest in the asteroseismic properties of red giants and the link with their global properties and internal structure is substantially increasing. Moreover, more and more precise data are being collected with the space-based telescopes CoRoT and Kepler. In this paper we present a survey of the most relevant theoretical and observational results obtained up to now concerning the potential of solar-like oscillations in red giants. [less ▲]

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See detailAvant-propos : mises au point et mises à jour
Lecocq, Pascale ULg

in Lecocq, Pascale (Ed.) La copropriété par appartements. Deux ans après la réforme (2012)

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See detailBranveiligheid - Brandveiligheid en berekening van de brandwerendheid van staalconstructies voor gebouwen volgens Eurocode 3
Cajot, Louis-Guy; Debruyckere, Rik; Franssen, Jean-Marc ULg

Book published by Infosteel (2012)

Dit boek behandelt in de eerste drie hoofdstukken het onderwerp brandveiligheid en de berekening van de brandwerendheid van staalconstructies voor gebouwen volgens Eurocode 3. Hoofdstuk 1 omschrijft de ... [more ▼]

Dit boek behandelt in de eerste drie hoofdstukken het onderwerp brandveiligheid en de berekening van de brandwerendheid van staalconstructies voor gebouwen volgens Eurocode 3. Hoofdstuk 1 omschrijft de doelstellingen van brandveiligheid aan de hand van het gedrag van een brand en bespreekt de maatregelen die een ontwerper kan nemen om te voldoen aan de eisen voor brandveiligheid en de wettelijk eisen. Hoofdstuk 2 gaat over het berekenen van de brandwerendheid van een staalconstructie met betrekking tot bezwijken. Een eenvoudig berekeningsmodel volgens Eurocode 3 wordt besproken en is geschikt voor trekstaven, niet-kipgevoelige liggers, kolommen én kipgevoelige liggers. Voor de berekening van geïntegreerde liggers, zowel onbekleed als bekleed wordt een geavanceerd rekenmodel gebruikt en wordt tevens een alternatieve vereenvoudigde methode voorgesteld. Hoofdstuk 3 behandelt het onderwerp fire safety engineering; een relatief nieuw vakgebied, waarbij fysische modellen worden gebruikt om het gedrag van een brand – en het effect hiervan op bouwwerken en de gebruikers – te beschrijven. Er worden vier situaties besproken die met fire safety engineering in de praktijk al zijn te berekenen: lokale branden, compartimentsbranden (zonder én met flashover), staalconstructies die zich buiten het gebouw bevinden in de buitenlucht én het systeemgedrag van een staalconstructie. Dit laatste wordt geillustreerd aan de hand van een staalplaat-betonvloer waarbij het membraaneffect in acht wordt genomen. Hoofdstuk 4 tenslotte bevat dertien ontwerptabellen voor het eenvoudig bepalen van een aantal rekenparameters zoals de afname van de effectieve vloeigrens en de elasticiteitsmodulus, de reductiefactor op de belastingen bij brand, de profielfactoren voor I-profielen, de staaltemperatuur na een bepaalde tijd (in functie van de profielfactor) en de kritieke staaltemperatuur voor kolommen (in functie van de benuttinggraad en slankheid). [less ▲]

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