References of "2012"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailTransfer of drug dissolution testing by statistical approaches: Case Study
AL-Kamarany, M. A.; EL Karbane, M.; Ridouan, K. et al

in Saudi Pharmaceutical Journal (2012), 20(1), 93101

The analytical transfer is a complete process that consists in transferring an analytical procedure from a sending laboratory to a receiving laboratory. After having experimentally demonstrated that also ... [more ▼]

The analytical transfer is a complete process that consists in transferring an analytical procedure from a sending laboratory to a receiving laboratory. After having experimentally demonstrated that also masters the procedure in order to avoid problems in the future. Method of transfers is now commonplace during the life cycle of analytical method in the pharmaceutical industry. No official guideline exists for a transfer methodology in pharmaceutical analysis and the regulatory word of transfer is more ambiguous than for validation. Therefore, in this study, Gauge repeatability and reproducibility (R&R) studies associated with other multivariate statistics appropriates were successfully applied for the transfer of the dissolution test of diclofenac sodium as a case study from a sending laboratory A (accredited laboratory) to a receiving laboratory B. The HPLC method for the determination of the percent release of diclofenac sodium in solid pharmaceutical forms (one is the discovered product and another generic) was validated using accuracy profile (total error) in the sender laboratory A. The results showed that the receiver laboratory B masters the test dissolution process, using the sameHPLC analytical procedure developed in laboratory A. In conclusion, if the sender used the total error to validate its analytical method, dissolution test can be successfully transferred without mastering the analytical method validation by receiving laboratory B and the pharmaceutical analysis method state should be maintained to ensure the same reliable results in the receiving laboratory. [less ▲]

Detailed reference viewed: 83 (5 ULg)
Full Text
Peer Reviewed
See detailAnalgésie péridurale obstétricale et lombalgie du post-partum: un lien de cause à effet?
CHARLIER, Vanessa ULg; Brichant, Géraldine ULg; DEWANDRE, Pierre-Yves ULg et al

in Revue Médicale de Liège (2012), 67(1), 16-20

backache is a common problem in the general population. the prevalence of backpain is increased during pregnancy and after delivery. early studies have suggested that labor epidural analgesia might be ... [more ▼]

backache is a common problem in the general population. the prevalence of backpain is increased during pregnancy and after delivery. early studies have suggested that labor epidural analgesia might be associated with an increased incidence of backache in the postpartum period. However, these initial studies were retrospective and their design included several methodological deficiencies. All the prospective studies published afterwards (prospective cohort studies and 3 ran- domized controlled trials) yield the same result : there is no relationship between labor epidural analgesia and long-term postpartum backpain. pregnant women must be aware of this in order to make an informed and appropriate choice about labor epidural analgesia, the most effective technique for intra- partum pain relief. [less ▲]

Detailed reference viewed: 176 (10 ULg)
Full Text
See detailMeasuring Downside and Extreme Risk Allocation in Equity Hedge Funds
Lambert, Marie ULg

E-print/Working paper (2012)

Detailed reference viewed: 25 (4 ULg)
Full Text
Peer Reviewed
See detailPratiques unilatérales
Sibony, Anne-Lise ULg; Marty, Frédéric; Wachsmann, Anne

in Concurrences : Revue des Droits de la Concurrence (2012), 1-2012

La Commission européenne condamne l’opérateur historique polonais de télécommunications pour avoir abusé de sa position dominante en entravant l’accès de nouveaux entrants au marché de l’Internet.

Detailed reference viewed: 37 (5 ULg)
Full Text
See detailLes étudiants sont-ils compétents pour évaluer la qualité des enseignements
Detroz, Pascal ULg

in Dierendonck, Christophe (Ed.) Actes du colloque du 24ème colloque de l'ADMEE (2012, January)

Detailed reference viewed: 29 (8 ULg)
Full Text
Peer Reviewed
See detailNeuropsychiatric Inventory data in a Belgian sample of elderly persons with and without dementia
Squelard, Gilles ULg; Missotten, Pierre ULg; Paquay, Louis et al

in Clinical Interventions in Aging (2012), 2(7), 423-430

Background/aims: This study assesses and compares prevalence of psychological and behavioral symptoms in a Belgian sample of people with and without dementia. Methods: A total of 228 persons older than 65 ... [more ▼]

Background/aims: This study assesses and compares prevalence of psychological and behavioral symptoms in a Belgian sample of people with and without dementia. Methods: A total of 228 persons older than 65 years with dementia and a group of 64 non- demented persons were assessed using the Neuropsychiatric Inventory (NPI) in 2004. Results: Within the group without dementia, the most frequent symptoms were depression, agitation, and irritability. Within the group with dementia, the most common symptoms were depression, irritability, apathy, and agitation. Prevalence of delusions (P [less ▲]

Detailed reference viewed: 56 (8 ULg)
Full Text
See detailMultiple Migrations, Displacements and Land Transfers at Ta Kream in Northwest Cambodia
Pilgrim, John; Ngin, Chanrith; Diepart, Jean-Christophe ULg

in Hecht, Susanna; Kandel, Susan; Morales, Abelardo (Eds.) Migration, Rural Livelihoods and Natural Resource Management (2012)

The Cambodian case examines migration, land tenure and land management, in a context of conflict and the use of force in land transfers since the time of the Khmer Rouge regime to the present, by studying ... [more ▼]

The Cambodian case examines migration, land tenure and land management, in a context of conflict and the use of force in land transfers since the time of the Khmer Rouge regime to the present, by studying five agro-ecological zones close to the Kamping Pouy irrigation system in Battambang Province. The study combines analysis of demographic and socioeconomic characteristics of household use of land and labor with a historical and ethnographic review of conflict and institutional factors in successive land administrations. Continuing in-migration is reflected in population increases in Battambang and other provinces of Northwest Cambodia in conditions of limited land availability and landlordism, and conflict over expropriation of land by armed groups and business interests. Land transfers to a growing wealthy class of businessmen and government officials have contributed to the creation of a subclass of very poor, landless households whose livelihoods depend on agricultural wage labor, locally and in Thailand, and access to the commons. Access to land for a substantial proportion of the community depends on either tenancy, sharecropping or wage labor on the land of wealthier farmers. Three problematic processes that run counter to the Cambodian Constitution and Land Law are systemic: 1) the usurpation of land rights by locally operating armed groups; 2) legitimation of such land acquisition by military-business-government officials by corrupt officeholders and local government officials; and 3) the capture of rents or profits by agencies responsible for safeguarding natural resources. [less ▲]

Detailed reference viewed: 29 (0 ULg)
See detailFP6 PROHITECH project: Volume 4: Seismic Protection of historical buildings: numerical analysis
Aleksovska, Marija; Altay Askar, Gülay; Aras, Fuat et al

Book published by Polimetrica (2012)

Detailed reference viewed: 69 (7 ULg)
Full Text
Peer Reviewed
See detailSpatial variability of leaf area index in homogeneous forests relates to local variation in tree characteristics
Bequet, R; Campioli, M; Kint, V et al

in Forest Science (2012), 58(6), 633-640

Detailed reference viewed: 26 (4 ULg)
Full Text
Peer Reviewed
See detailUstekinumab in psoriasis immunopathology with emphasis on the Th17-IL23 axis. A primer.
QUATRESOOZ, Pascale ULg; Hermanns-Le, Trinh ULg; Pierard, Gérald ULg et al

in Journal of Biomedicine & Biotechnology (2012), 2012(147413),

Psoriasis is a chronic relapsing immunoinflammatory dermatosis that is commonly associated with systemic comorbidities. The pathogenic importance of interleukin (IL)-12 and IL-23 is beyond doubt, as well ... [more ▼]

Psoriasis is a chronic relapsing immunoinflammatory dermatosis that is commonly associated with systemic comorbidities. The pathogenic importance of interleukin (IL)-12 and IL-23 is beyond doubt, as well as the involvement of T helper cells (Th)1 and Th17 cells. There is upregulation of the p40 subunit shared by IL-12 and IL-23 and of the IL-23 p19 subunit, but not an increased expression of the IL-12 p35 subunit. This indicates that IL-23 appears more involved than IL-12 in the pathogenesis of psoriatic plaques. Ustekinumab is a fully human monoclonal antibody of the immunoglobulin (Ig) G1 class targeting the p40 subunit common to both IL-12 and IL-23, thus inhibiting both IL-12 and IL-23 receptor-mediated signalling. Ustekinumab is part of the recent biologic therapies active in psoriasis, autoimmune arthritides, and inflammatory bowel diseases. [less ▲]

Detailed reference viewed: 24 (3 ULg)
Full Text
Peer Reviewed
See detailUranus Pathfinder: exploring the origins and evolution of Ice Giant planets
Arridge, Christopher S.; Agnor, Craig B.; Andre, Nicolas et al

in Experimental Astronomy (2012)

The "Ice Giants" Uranus and Neptune are a different class of planet compared to Jupiter and Saturn. Studying these objects is important for furthering our understanding of the formation and evolution of ... [more ▼]

The "Ice Giants" Uranus and Neptune are a different class of planet compared to Jupiter and Saturn. Studying these objects is important for furthering our understanding of the formation and evolution of the planets, and unravelling the fundamental physical and chemical processes in the Solar System. The importance of filling these gaps in our knowledge of the Solar System is particularly acute when trying to apply our understanding to the numerous planetary systems that have been discovered around other stars. The Uranus Pathfinder (UP) mission thus represents the quintessential aspects of the objectives of the European planetary community as expressed in ESA's Cosmic Vision 2015-2025. UP was proposed to the European Space Agency's M3 call for medium-class missions in 2010 and proposed to be the first orbiter of an Ice Giant planet. As the most accessible Ice Giant within the M-class mission envelope Uranus was identified as the mission target. Although not selected for this call the UP mission concept provides a baseline framework for the exploration of Uranus with existing low-cost platforms and underlines the need to develop power sources suitable for the outer Solar System. The UP science case is based around exploring the origins, evolution, and processes at work in Ice Giant planetary systems. Three broad themes were identified: (1) Uranus as an Ice Giant, (2) An Ice Giant planetary system, and (3) An asymmetric magnetosphere. Due to the long interplanetary transfer from Earth to Uranus a significant cruise-phase science theme was also developed. The UP mission concept calls for the use of a Mars Express/Rosetta-type platform to launch on a Soyuz-Fregat in 2021 and entering into an eccentric polar orbit around Uranus in the 2036-2037 timeframe. The science payload has a strong heritage in Europe and beyond and requires no significant technology developments. [less ▲]

Detailed reference viewed: 29 (3 ULg)
Full Text
Peer Reviewed
See detailAcute and Specific Modulation of Presynaptic Aromatization in the Vertebrate Brain
Cornil, Charlotte ULg; Leung, Cary H.; Pletcher, Eric R. et al

in Endocrinology (2012), 153(6), 2562-7

Estrogens affect a diversity of peripheral and central physiological endpoints. Traditionally, estrogens were thought to be peripherally derived transcription regulators (i.e. slow acting). More recently ... [more ▼]

Estrogens affect a diversity of peripheral and central physiological endpoints. Traditionally, estrogens were thought to be peripherally derived transcription regulators (i.e. slow acting). More recently, we have learned that estrogens are also synthesized in neuronal cell bodies and synaptic terminals and have potent membrane effects, which modulate brain function. However, the mechanisms that control local steroid concentrations in a temporal and spatial resolution compatible with their acute actions are poorly understood. Here, using differential centrifugation followed by enzymatic assay, we provide evidence that estrogen synthesis within synaptosomes can be modulated more dramatically by phosphorylating conditions, relative to microsomes. This is the first demonstration of a rapid mechanism that may alter steroid concentrations within the synapse and may represent a potential mechanism for the acute control of neurophysiology and behavior. [less ▲]

Detailed reference viewed: 7 (3 ULg)
Full Text
See detailL'approche des services écosystémiques pour la gestion intégrée des territoires
Dufrêne, Marc ULg

Conference given outside the academic context (2012)

Detailed reference viewed: 43 (10 ULg)
Full Text
Peer Reviewed
See detailUn siècle de production et de distribution intercommunale d’eau alimentaire en région liégeoise
Geerkens, Eric ULg

in Raxhon, Philippe (Ed.) Liège à la conquête de l'eau: Des origines au centenaire de la CILE (2012)

Detailed reference viewed: 22 (1 ULg)