Les troubles de la thermorégulation de l'enfant avec cas illustrés.

Book published by les éditions de l'Université de Liège (2012)

European outbreaks of atypical myopathy in grazing equids (2006-2009). Spatiotemporal distribution, history and clinical features

in Equine Veterinary Journal (2012)

Étude de l’évolution de l’oxydation lipidique du Tilapia du Nil (Oreochromis niloticus) conservé à température ambiante (30°C) et à (4°C), en Algérie.

Poster (2012)

Efficacy and safety of maribavir dosed at 100 mg orally twice daily for the prevention of cytomegalovirus disease in liver transplant recipients: a randomized, double-blind, multicenter controlled trial.

in American Journal of Transplantation (2012), 12(11), 3021-30

Maribavir is an oral benzimidazole riboside with potent in vitro activity against cytomegalovirus (CMV), including some CMV strains resistant to ganciclovir. In a randomized, double-blind, multicenter ... [more ▼]

Maribavir is an oral benzimidazole riboside with potent in vitro activity against cytomegalovirus (CMV), including some CMV strains resistant to ganciclovir. In a randomized, double-blind, multicenter trial, the efficacy and safety of prophylactic oral maribavir (100 mg twice daily) for prevention of CMV disease were compared with oral ganciclovir (1000 mg three times daily) in 303 CMV-seronegative liver transplant recipients with CMV-seropositive donors (147 maribavir; 156 ganciclovir). Patients received study drug for up to 14 weeks and were monitored for CMV infection by blood surveillance tests and also for the development of CMV disease. The primary endpoint was Endpoint Committee (EC)-confirmed CMV disease within 6 months of transplantation. In a modified intent-to-treat analysis, the noninferiority of maribavir compared to oral ganciclovir for prevention of CMV disease was not established (12% with maribavir vs. 8% with ganciclovir: event rate difference of 0.041; 95% CI: -0.038, 0.119). Furthermore, significantly fewer ganciclovir patients had EC-confirmed CMV disease or CMV infection by pp65 antigenemia or CMV DNA PCR compared to maribavir patients at both 100 days (20% vs. 60%; p < 0.0001) and at 6 months (53% vs. 72%; p = 0.0053) after transplantation. Graft rejection, patient survival, and non-CMV infections were similar for maribavir and ganciclovir patients. Maribavir was well-tolerated and associated with fewer hematological adverse events than oral ganciclovir. At a dose of 100 mg twice daily, maribavir is safe but not adequate for prevention of CMV disease in liver transplant recipients at high risk for CMV disease. [less ▲]

Blossom-Quad: a non-uniform quadrilateral mesh generator using a minimum cost perfect matching algorithm

in International Journal for Numerical Methods in Engineering (2012), 89

A RAPID VALIDATED UHPLC-PDA METHOD FOR ANTHOCYANINS QUANTIFICATION FROM EUTERPE OLERACEA FRUITS

Poster (2012)

Commercialization of Euterpe oleracea fruit has increased because of its abundance in anthocyanins [1]. Characterizations of these compounds are important for the food industry. The aim is to validate an ... [more ▼]

Commercialization of Euterpe oleracea fruit has increased because of its abundance in anthocyanins [1]. Characterizations of these compounds are important for the food industry. The aim is to validate an UHPLC-PDA method for major anthocyanins quantification in this fruit after fast extraction procedures and samples preparation. Fruits were harvested in Abaetetuba (Brazil) and extracted sequencially by EtOAc, MeOH and MeOH 50% all at 0.1% HCl. A HSS C18 column (1.8µm) was used with a gradient elution of ACN and 5% HCOOH. Total error and accuracy profiles were used as validation criteria. A first EtOAc extraction removes the lipophilic compounds and allows an easier extraction by MeOH and quantification of anthocyanins in this extract. It was found to be faster (17 min) that HPLC-UV methods [2]. Calibration in the matrix was found to be more accurate than calibration without matrix. Trueness (<6.76% relative bias), repeatability (<4.6% RSD), intermediate precision (<5.3% RSD), selectivity (by UHPLC-ESI+-HRMS), response function and linearity for cyanidin-3-glucoside and cyanidin-3-rutinoside were evaluated. The concentration range validated was 1 to 48 µg/mL for both compounds. [less ▲]

Fifty Years of Quasars. From Observations to Physical Parameters

in D'Onofrio, M. (Ed.) Fifty Years of Quasars: From Early Observations and Ideas to Future Research (2012)

Observational measures of AGNs allow us to directly infer some basic physical properties of quasars including (1) physical conditions and chemical abundances in the broad-line emitting gas as well as (2 ... [more ▼]

Observational measures of AGNs allow us to directly infer some basic physical properties of quasars including (1) physical conditions and chemical abundances in the broad-line emitting gas as well as (2) radius of the line-emitting region, (3) black hole mass, (4) and Eddington ratio. In this chapter, we seek information on how these quantities are measured. One of the surprises of recent times, that would have shocked the discoverers in the 1960s are the large BH masses and high chemical abundances inferred for even some of the highest redshift quasars known. [less ▲]

Solutal Marangoni instability of binary mixtures evaporating into air: an analytical model describing highly unstable cases

Poster (2012)

The tomato leafminer reproduces without a mate: New case of parthenogenesis in Lepidoptera

Poster (2012)

The tomato leafminer, Tuta absoluta (Lepidoptera: Gelechiidae), originates from South America and is now considered to be one of the most damaging invasive pests of tomatoes in the Mediterranean Basin ... [more ▼]

The tomato leafminer, Tuta absoluta (Lepidoptera: Gelechiidae), originates from South America and is now considered to be one of the most damaging invasive pests of tomatoes in the Mediterranean Basin countries of Europe and North Africa. The preventing pest mating control methods include: (1) the use of synthetic pheromones for male attraction and annihilation inside insecticide-contain- ing traps; (2) mating disruption by saturating the atmosphere with sex pheromones which alter the ability of males to locate females; and (3) massive applications of sterile males to alter the overall reproductive success of the pest popula- tion. However, all these methods achieve only a poor success rate in controlling T. absoluta populations under greenhouse conditions. Sex pheromone management and sterile insect techniques are both based on an important biological trait: the insect must breed through sexual reproduction. Here, we report for the first time laboratory evidence of deuterotokous parthenogenesis, an asexual reproduction where both males and females are produced from unfertilized eggs. [less ▲]

Partial trisomy 4q associated with young-onset dopa-responsive parkinsonism.

in Archives of Neurology (2012), 69(3), 398-400

OBJECTIVE: To describe a patient who developed a young-onset, dopa-responsive parkinsonism linked to a de novo heterozygous interstitial duplication 4q. DESIGN: Case report. SETTING: Movement Disorder ... [more ▼]

OBJECTIVE: To describe a patient who developed a young-onset, dopa-responsive parkinsonism linked to a de novo heterozygous interstitial duplication 4q. DESIGN: Case report. SETTING: Movement Disorder Outpatient Clinic at the University Hospital Centre, Liege, Belgium. Patient A 31-year-old woman. MAIN OUTCOME MEASURES: Clinical, neuroimaging, and genetic data. RESULTS: The duplicated region contains 150 known genes, including the alpha-synuclein (SNCA) gene locus. Motor and 6-[(18)F]fluoro-L-dopa positron emission tomography features are similar to those previously reported in heterozygote SNCA duplication carriers. Altered expression of other genes contained in the duplicated region may contribute to clinical features that are uncommon in the phenotypic spectrum of SNCA multiplications such as delayed developmental psychomotor milestones during infancy and musculoskeletal abnormalities. CONCLUSION: This case report provides new insights on the genetic basis of parkinsonism. [less ▲]