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See detailCyclophosphamide inhibits the generation and function of CD8(+) regulatory T cells
Conteduca, Giuseppina ULg

in Human Immunology (2012), 73(3), 207-13

CD8(+) regulatory T cells (Treg) and CD4(+)CD25(+) Treg infiltrate human cancers, thus favoring tumor immune escape. Therefore, in the setting of antitumor therapeutic protocols, it is important to ... [more ▼]

CD8(+) regulatory T cells (Treg) and CD4(+)CD25(+) Treg infiltrate human cancers, thus favoring tumor immune escape. Therefore, in the setting of antitumor therapeutic protocols, it is important to associate antitumor treatment with agents that are able to inhibit Treg function. Cyclophosphamide (CY) has been demonstrated to be effective in counteracting CD4(+)CD25(+) Treg activity. Hence, we tested its inhibitory efficacy on human CD8(+) Treg. Because CY is a prodrug, 4-hydroperoxycyclophosphamide (4-HC), a derivative of CY that in aqueous solution is converted to 4-hydroxycyclophosphamide, an active metabolite of CY, was used. 4-HC significantly inhibited CD8(+) Treg generation and function but only at the higher tested concentration (0.5 μg/mL), that is, in the therapeutic range of the drug. The lower 4-HC concentration tested (0.1 μg/mL) was almost ineffective. 4-HC inhibitory effects were related to apoptosis/necrosis induction. When CD8(+)CD28(+) non-Treg were analyzed for comparative purposes, significantly lower cytotoxic rates among these cells were observed than among CD8(+) Treg, which were differentiated because they did not express the CD28 molecule. These data demonstrate that CD8(+) Treg are inhibited through cytotoxic phenomena by CY, thus supporting the use of this drug at adequate concentrations and schedules of administration as a Treg inhibitor in combinatorial chemo- or immunotherapeutic anticancer protocols. [less ▲]

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See detailCarbohydrate-based surfactants: structure-activity relationships
Razafindralambo, Hary ULg; Blecker, Christophe ULg; Paquot, Michel ULg

in Nawaz, Zeeshan; Naveed, Shahid (Eds.) Advances in Chemical Engineering (2012)

The aim of the present contribution is: (1) to review CBS in terms of structural classification based on their molecular size (mono-, oligo-, polymeric surfactants), geometry (standard, bipolar or ... [more ▼]

The aim of the present contribution is: (1) to review CBS in terms of structural classification based on their molecular size (mono-, oligo-, polymeric surfactants), geometry (standard, bipolar or bolaform, and gemini surfactants), and the nature of the polar headgroup (charged or not, cyclic or not), the apolar tail (number and length of alkyl chain), and the linker (amide, ester, ...) and/or the spacer; (2) to present systematically results on structure- activity relationships of uronic acid derivatives (UADs), a particular class of carbohydrate-based surfactants. These concern the impact of each structural entity including the polar headgroup (stereochemistry), apolar tail (chain length, number, and unsaturation), and linkage/spacer, on the performance of UADs to change surface properties, and possibly, to form and stabilize colloidal systems. [less ▲]

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See detailHeisenberg-limited metrology without entanglement
Braun, Daniel; Martin, John ULg

Conference (2012, March)

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See detailLes innombrables formes des Mille et une Nuits : quelques éditions, traditions, traductions... et trahisons
Franssen, Elise ULg

in La lettre du Réseau. Une Publication du Réseau des médiévistes belges de langue française (RMBLF) (2012), 2

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See detailcarnet de pédiatrie en Afrique: Les conséquences de la prématurité
Battisti, Oreste ULg

Learning material (2012)

cours de master complémentaire en pédiatrie.

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See detailA candidate cell of origin for cervical cancer
Herfs, Michael ULg

Conference (2012, March)

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See detailSuccessful treatment of equine sarcoids with cisplatin electrochemotherapy: a retrospective study of 48 cases.
Tamzali, Y; Borde, Laura ULg; Rols, MP et al

in Equine Veterinary Journal (2012), 44(2), 214-220

REASONS FOR PERFORMING STUDY: Sarcoids are the commonest form of equine skin tumour. Several therapeutic measures have been described but none is considered to be universally effective ... [more ▼]

REASONS FOR PERFORMING STUDY: Sarcoids are the commonest form of equine skin tumour. Several therapeutic measures have been described but none is considered to be universally effective. Electrochemotherapy (ECT) is a new anticancer therapy that utilises electrical field pulses to induce increased cell membrane permeability to antitumour hydrophilic drugs, such as cisplatin. The increased intracellular concentration of the drugs has a significant therapeutic benefit. The procedure has not been previously reported in a large number of horses. OBJECTIVE: To validate ECT as a novel alternative treatment for equine sarcoids. METHODS: A retrospective study evaluating the efficacy of cisplatin ECT in the treatment of equine sarcoids was performed. Electrochemotherapy treatments were applied under general anaesthesia at 2 week intervals with or without prior excision or debulking. Electric pulses were directly applied to the lesions following intra-tumoural injections of an aqueous solution of cisplatin. RESULTS: One-hundred-and-ninety-four sarcoids on 34 horses, 2 ponies, 11 donkeys and one mule were treated with ECT. The 4 year nonrecurrence rate was 97.9% for animals (47/48) and 99.5% (193/194) for tumours. When ECT was used as a single treatment, a significant influence of tumour size (ρ= 0.55) on the number of treatments required for cure was shown. When prior surgery was performed, there was a significant influence (P<0.001) of the excision quality (complete or incomplete) and the healing mode (closed or open wound) on the number of treatments. The most common adverse effect was a slight oedematous reaction for lesions located on thin skin regions. CONCLUSION AND CLINICAL RELEVANCE: Results demonstrate that ECT, with or without concurrent tumour debulking, is an effective alternative for treatment of equine sarcoids [less ▲]

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See detailStructured differential diagnosis of a transient impairment of consciousness
HANSEN, Isabelle ULg; MELON, P.; CREEMERS, Etienne ULg et al

in Revue Médicale de Liège (2012), 67(3),

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See detailComment on “Primum non noccere”.
Desseilles, Martin ULg; Fava, Maurizio; Mischoulon, David et al

in Current Psychiatry (2012), 11(10), 9-10

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See detailClinical Tools for A Personalized Treatment Strategy in Depression.
Desseilles, Martin ULg; Witte, Janet; Trina, E. Chang et al

in Current Psychiatry (2012), 11(3), 26-33

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See detailArt public : entre pratiques sauvages et commandes officielles
Hagelstein, Maud ULg

in Cahiers Nouveaux (Les) (2012), 81

L’expression «art public» désigne l’ensemble des oeuvres d’art qui ont été commandées, planifiées et exécutées en vue d’être placées dans un espace public. Partant de cette définition sommaire, on ... [more ▼]

L’expression «art public» désigne l’ensemble des oeuvres d’art qui ont été commandées, planifiées et exécutées en vue d’être placées dans un espace public. Partant de cette définition sommaire, on pourrait être tenté d’établir une différence entre un art public de commande et un art public plus sauvage : d’un côté, une instance publique souhaite qu’un artiste produise une oeuvre reflétant l’état d’esprit d’un environnement urbain donné et de ses habitants ; de l’autre, les artistes font des percées intempestives dans le paysage visuel de la ville – et ce, sans qu’on leur ait rien demandé. Cette distinction servirait une stratégie sans doute grossière visant à séparer au sein de l’espace public art de convenance et art subversif. Là où les uns essaieraient de rencontrer les goûts normés du citoyen moyen, les autres prendraient au contraire le risque de la désapprobation en déstabilisant les codes en vigueur et les normes esthétiques. Mais cette opposition entre art de convenance et art subversif constitue probablement un cliché grotesque. Aussi adoptera-t-on un point de vue plus fécond en montrant plutôt les contiguïtés entre l’art de commande et de l’art sauvage. Dans un cas comme dans l’autre, dès que les oeuvres d’art sont publiques, elles posent des problèmes spécifiques. Quels que soient les objectifs qui l’animent, dès qu’il franchit les murs de l’institution, du musée ou de la galerie, l’artiste prend un risque considérable. Et au fond, que sa proposition artistique soit autorisée ou illégale, d’un certain point de vue, le risque demeure. C’est ce qu’il s’agira ici d’identifier. [less ▲]

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See detailLe pancréas artificiel: un rêve devenu presque réalité
RADERMECKER, Régis ULg

in Revue de l'Association Belge du Diabète (2012), 55

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See detailLes grandes études de la littérature utilisant la mesure continue du glucose
RADERMECKER, Régis ULg

in Revue de l'Association Belge du Diabète/ Supplément médical (2012), 55

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See detailMesoscopic transport with ultracold atoms
Schlagheck, Peter ULg

Conference (2012, March)

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See detailLa prothèse fixe minimalement invasive.
MAINJOT, Amélie ULg

Conference (2012, March)

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See detailPrinciples for nearly zero energy building in Belgium
Attia, Shady ULg; Mlecnik, Erwin

in World Sustainable Energy Days (2012, February 29)

The recast of the European Performance of Buildings Directive (EPBD) requires all new buildings to be “nearly zero energy’ buildings (nZEB) by 2020, including existing buildings undergoing major ... [more ▼]

The recast of the European Performance of Buildings Directive (EPBD) requires all new buildings to be “nearly zero energy’ buildings (nZEB) by 2020, including existing buildings undergoing major renovations. Belgium was first to set a definition for a ‘net zero energy house’ (NZEB) in 2009. Every year the definition is revised for consistency with shortcomings and emerging issues. However, to reach the nZEB objective many questions are raised in the Belgian context. Many uncertainties exist among local governments and municipalities to achieve that objective. Therefore, the paper presents a review on the current Belgian definition and its market status in comparison with the international context. The paper builds on existing experience with the implementation of the EPB calculation method and the Passive House initiative. The aim of the paper is to review current definition discussions and pave the way to a more consistent definition. Finally, four principles are suggested to reach the nZEB objectives in Belgium. [less ▲]

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See detailAvoiding the elephant: the net and nearly zero energy building target in Belgium
Attia, Shady ULg; Mlecnik, Erwin

in World Sustainable Energy Days (2012, February 29)

The recast of the European Performance of Buildings Directive (EPBD) requires all new buildings to be “nearly zero energy’ buildings (nZEB) by 2020, including existing buildings undergoing major ... [more ▼]

The recast of the European Performance of Buildings Directive (EPBD) requires all new buildings to be “nearly zero energy’ buildings (nZEB) by 2020, including existing buildings undergoing major renovations. Belgium was even first to set a definition for a ‘net zero energy house’ (NZEB) in 2009. The revised Energy Performance in Buildings Directive calls governments to meet the nearly zero energy targets by 2020. Governments must adopt and publish regulations and procedures for the other requirements mainly the cost optimal calculation by July 2012. There are many elements of the recast Directive that pertain to new buildings. Unfortunately, the recast does not set targets for improving existing buildings and non-legislative measures will be needed to address how to achieve a greater share of renovation. Therefore, this paper aims to identify the share of the newly constructed buildings by 2020 in Belgium. The objective is to put the nearly zero energy targets in a wider perspective in relation to the existing building stock. The paper investigates some future scenarios for the national buildings stock growth rate, coupled with demographic growth by 2050. The study’s final results indicate that newly constructed building will be less than 7% by 2020 and less than 15% by 2050 in Belgium. Thus by not addressing the potential for energy renovations in the building sector the EPBD is avoiding the elephant. [less ▲]

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See detailFirst occurrence of the lungfish Sagenodus (Dipnoi, Sarcopterygii) from the Carboniferous Lagerstätte of Montceau-les-Mines, France
Olive, Sébastien ULg; Clément, Gaël; Pouillon, Jean-Marc

in Journal of Vertebrate Paleontology (2012), 32(2), 285-295

New material of the dipnoan genus Sagenodus is described from the Carboniferous Lagerstätte of Montceau-les-Mines, Massif Central, France. This is the first occurrence of this lungfish in France, thus ... [more ▼]

New material of the dipnoan genus Sagenodus is described from the Carboniferous Lagerstätte of Montceau-les-Mines, Massif Central, France. This is the first occurrence of this lungfish in France, thus enlarging its worldwide distribution; and the first occurrence of a lungfish in Montceau-les-Mines, thus increasing the vertebrate taxa list of this Lagerstätte. This material is Stephanian B in age, the previously established geological range of this Euramerican genus. Remains consist of skull, lower jaw, operculum, and shoulder girdle elements closely set together with several ribs. This material, here considered as belonging to a single disarticulated specimen, shows strong affinities with the material of Sagenodus sp. from Germany and appears significantly different from all other known species of Sagenodus by the shape and ridge pattern of the upper tooth plate. However, this new material can only be attributed to Sagenodus sp. due to its incompleteness. In the literature, Montceau-les-Mines is either interpreted as a freshwater environment or as a coastal marine to marine-influenced environment. As Sagenodus is a euryhaline genus; its presence in this locality does not bring arguments to one or the other assumption. The strong affinities, existing between the material from France and Germany, indicate that there were solid hydrographic links between both basins during the Stephanian B–Upper Rotliegend period. [less ▲]

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