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See detailSerial translocation by means of circular intermediates underlies colour sidedness in cattle.
Durkin, Keith ULg; Coppieters, Wouter ULg; Drogemuller, Cord et al

in Nature (2012), 482(7383), 81-4

Colour sidedness is a dominantly inherited phenotype of cattle characterized by the polarization of pigmented sectors on the flanks, snout and ear tips. It is also referred to as 'lineback' or 'witrik ... [more ▼]

Colour sidedness is a dominantly inherited phenotype of cattle characterized by the polarization of pigmented sectors on the flanks, snout and ear tips. It is also referred to as 'lineback' or 'witrik' (which means white back), as colour-sided animals typically display a white band along their spine. Colour sidedness is documented at least since the Middle Ages and is presently segregating in several cattle breeds around the globe, including in Belgian blue and brown Swiss. Here we report that colour sidedness is determined by a first allele on chromosome 29 (Cs(29)), which results from the translocation of a 492-kilobase chromosome 6 segment encompassing KIT to chromosome 29, and a second allele on chromosome 6 (Cs(6)), derived from the first by repatriation of fused 575-kilobase chromosome 6 and 29 sequences to the KIT locus. We provide evidence that both translocation events involved circular intermediates. This is the first example, to our knowledge, of a phenotype determined by homologous yet non-syntenic alleles that result from a novel copy-number-variant-generating mechanism. [less ▲]

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See detailAn Integer Programming model for air transport of hazardous and special shipments
Kleyntssens, Thomas ULg; Limbourg, Sabine ULg; Schyns, Michael ULg

Conference (2012, February 02)

The aircraft loading problem is a real-world combinatorial optimisation problem highly constrained. This weight must be distributed to keep the centre of gravity within speci ed limits. Moreover, an ... [more ▼]

The aircraft loading problem is a real-world combinatorial optimisation problem highly constrained. This weight must be distributed to keep the centre of gravity within speci ed limits. Moreover, an aircraft has usually several cargo compart- ments with speci c contours and structural limitations such as oor loading, com- bined load limits and cumulative load limitations. Finally, some shipments are par- ticularly restrictive to transport, like dangerous goods, live animals and perishable goods. This paper is concerned with the incorporation of these latter constraints in a mixed integer linear program for the problem of loading a set of Unit Load- ing Devices and bulk into an aircraft. Experimental results show that our method achieves optimal solutions within only few seconds. [less ▲]

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See detailThree dimensional Bin Packing Problem applied to air transport
Paquay, Célia ULg; Schyns, Michael ULg; Limbourg, Sabine ULg

Conference (2012, February 02)

Packing boxes into containers is a daily process in many di erent elds and especially in transport. However, the particular case of air transport brings some new constraints such as the stability or the ... [more ▼]

Packing boxes into containers is a daily process in many di erent elds and especially in transport. However, the particular case of air transport brings some new constraints such as the stability or the fragility of the cargo. The distribution of the weight has also to be considered. Moreover, this special case also brings some data such as the dimensions of the possible containers, called Unit Load Devices. This paper is concerned with the formulation of the three dimensional palletization which includes the main constraints met in the air cargo industry. It proposes a integer linear program for this combinatorial optimization problem. [less ▲]

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See detailÉvaluation de l’impact de l’extrapolation de bioréacteur sur la physiologie de Yarrowia lipolytica pour la production de lipase
Kar, Tambi ULg

Doctoral thesis (2012)

Les travaux entrepris au cours de cette thèse visent à mettre en place une méthodologie globale d’extrapolation de bioréacteurs. Le procédé de production de lipase par Yarrowia lipolytica a été plus ... [more ▼]

Les travaux entrepris au cours de cette thèse visent à mettre en place une méthodologie globale d’extrapolation de bioréacteurs. Le procédé de production de lipase par Yarrowia lipolytica a été plus particulièrement investigué, compte tenu de la complexité du système biologique et des paramètres physico-chimiques mis en œuvre. En effet, ce procédé met en œuvre une levure dite non conventionnelle dans un réacteur multiphasique G-L-L comprenant un substrat hydrophobe (le méthyloléate étant utilisé comme source de carbone renouvelable). Du fait du caractère strictement aérobie de ce type de levure, le transfert d’oxygène est un paramètre critique pour ce procédé. Dans un premier temps, l’ensemble des paramètres physico-chimiques clés du procédé ont été investigués (c’est-à-dire la dispersion du méthyloléate, les fluctuations en oxygène dissous et en pH). Cette évaluation a été menée en se basant sur des paramètres physico-chimiques (mélange du réacteur, transfert d’oxygène,…), mais également sur base de paramètres biologiques (synthèse et excrétion de la lipase, activation du gène lip2,…). Cette première étude a démontré que le paramètre critique était la fluctuation de l’oxygène dissous, ce paramètre menant à une réduction du rendement spécifique en lipase, liée à une atténuation de l’activité du gène lip2 codant pour la lipase extracellulaire de Y. lipolytica. Ce paramètre est d’autant plus important que les amplitudes des fluctuations en oxygène dissous sont amplifiées lors du processus de montée en échelle pour l’extrapolation du procédé. L’efficacité de dispersion du substrat hydrophobe (méthyloléate) au sein du milieu aqueux ne semble pas avoir d’impact sur l’efficacité du procédé, la levure sécrétant un biosurfactant permettant de stabiliser la dispersion. Les fluctuations en pH ont également peu d’impact sur le rendement de production de lipase, mais des observations au microscope ont révélé un début de dimorphisme cellulaire. Cette observation démontre la complexité de la réponse du système biologique face aux conditions de procédé. L’impact des fluctuations en oxygène dissous sur l’activité du gène lip2 a été confirmé par des analyses plus poussées en PCR quantitative (RT-qPCR). La deuxième partie du travail a donc été focalisée sur l’optimisation du transfert d’oxygène. Cette optimisation n’est pas triviale si on considère le phénomène de formation de mousse important lorsque la dispersion G-L au sein du réacteur est trop fine. Deux stratégies antimousse ont donc été envisagées : l’une mettant en œuvre l’ajout d’antimousse chimique et l’autre l’emploi d’un briseur de mousse mécanique. Cette dernière méthode s’est révélée inefficace du fait de la formation d’une couche de mousse persistante entre la surface du liquide et la turbine du briseur de mousse. Des analyses en cytométrie en flux ont permis d’observer un phénomène de dimorphisme qui semble lié au passage des cellules microbiennes au travers de cette couche de mousse, ce qui diminue le rendement en lipase. L’ajout d’antimousse chimique a donc été retenu et le transfert d’oxygène a pu être optimisé en fonction de contraintes de formation de mousse en considérant un enrichissement progressif de l’air d’entrée en oxygène pur. La dernière partie du travail a consisté à estimer l’extrapolation du procédé en prenant en compte à la fois les contraintes physico-chimiques du système (optimisation du transfert d’oxygène et limitation de la formation de mousse), ainsi que les contraintes biologiques. Cette extrapolation a tout d’abord été estimée au niveau de réacteurs scale-down permettant de reproduire les défauts d’écoulement généralement rencontrés au niveau industriel. De manière surprenante, cette étude a démontré que suite à l’adaptation physiologique des micro-organismes aux conditions d’écoulement, les problèmes de formation de mousse étaient de moins en moins marqués au cours de la montée en échelle du procédé. Cette observation va à l’encontre des calculs du génie chimique qui prédisent une augmentation du volume de mousse généré suite à la montée en volume des bioréacteurs et a été validée au niveau d’un bioréacteur pilote de 500L. Cela nous mène à conclure que la présence d’hétérogénéités au sein du volume réactionnel ne doit pas forcément être considérée comme un facteur négatif et pourrait au contraire être exploitée afin d’améliorer les performances des procédés et le design des bioréacteurs. [less ▲]

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See detailEffet des antibiotiques sur le procédé de traitement des eaux par boues activées ; étude à l’échelle du pilote et du floc par microscopie 3D
Potier, Olivier; Louvet, Jean-Noël ULg; Pons, Marie-Noëlle et al

Conference (2012, February 02)

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See detailHybrid Tabu Search Heuristics for a Bilevel Competitive Facility Location Model
Kucukaydin, Hande ULg; Aras, Necati; Altinel, I. Kuban

Conference (2012, February 02)

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See detailLa gravure à Liège au temps de Lambert Lombard
Warnauts, Samuelle ULg

Scientific conference (2012, February 02)

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See detailFirst results for the solar neighborhood of the Asiago Red Clump Survey
Valentini, Marica ULg; Munari, U.; Saguner, T. et al

in European Physical Journal Web of Conferences (2012, February 01)

The Asiago Red Clump Spectroscopic Survey (ARCS) is an ongoing survey that provides atmospheric parameters, distances and space velocities of a well selected sample of Red Clump stars distributed along ... [more ▼]

The Asiago Red Clump Spectroscopic Survey (ARCS) is an ongoing survey that provides atmospheric parameters, distances and space velocities of a well selected sample of Red Clump stars distributed along the celestial equator. We used the ARCS catalog for a preliminary investigation of the Galactic disk in the Solar Neighborhood, in particular we focused on detection and characterization of moving groups. [less ▲]

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See detailConception de l’usinage – optimisation des opérations de tournage
Trif, David Ioan ULg

Scientific conference (2012, February 01)

Cet article présente les démarches prises pour établir un programme d'optimisation en tournage. L'utilisateur aura a sa disposition un grand nombre de paramètres importants pour l’opération de tournage ... [more ▼]

Cet article présente les démarches prises pour établir un programme d'optimisation en tournage. L'utilisateur aura a sa disposition un grand nombre de paramètres importants pour l’opération de tournage, avec un minimum de données d'entrée. [less ▲]

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See detailCOSMOGRAIL: the COSmological MOnitoring of GRAvItational Lenses X. Modeling based on high-precision astrometry of a sample of 25 lensed quasars: consequences for ellipticity, shear, and astrometric anomalies
Sluse, Dominique ULg; Chantry, Virginie ULg; Magain, Pierre ULg et al

in Astronomy and Astrophysics (2012), 538

Gravitationally lensed quasars can be used as powerful cosmological and astrophysical probes. We can (i) infer the Hubble constant H0 based on the so-called time-delay technique, (ii) unveil substructures ... [more ▼]

Gravitationally lensed quasars can be used as powerful cosmological and astrophysical probes. We can (i) infer the Hubble constant H0 based on the so-called time-delay technique, (ii) unveil substructures along the line-of-sight toward distant galaxies, and (iii) compare the shape and the slope of baryons and dark matter distributions in the inner regions of galaxies. To reach these goals, we need high-accuracy astrometry of the quasar images relative to the lensing galaxy and morphology measurements of the lens. In this work, we first present new astrometry for 11 lenses with measured time delays, namely, JVAS B0218+357, SBS 0909+532, RX J0911.4+0551, FBQS J0951+2635, HE 1104-1805, PG 1115+080, JVAS B1422+231, SBS 1520+530, CLASS B1600+434, CLASS B1608+656, and HE 2149-2745. These measurements proceed from the use of the Magain-Courbin-Sohy (MCS) deconvolution algorithm applied in an iterative way (ISMCS) to near-IR HST images. We obtain a typical astrometric accuracy of about 1-2.5 mas and an accurate shape measurement of the lens galaxy. Second, we combined these measurements with those of 14 other lensing systems, mostly from the COSMOGRAIL set of targets, to present new mass models of these lenses. The modeling of these 25 gravitational lenses led to the following results: 1) in four double-image quasars (HE0047-1746, J1226-006, SBS 1520+530, and HE 2149-2745), we show that the influence of the lens environment on the time delay can easily be quantified and modeled, hence putting these lenses with high priority for time-delay determination; 2) for quadruple-image quasars, the difficulty often encountered in reproducing the image positions to milli-arcsec accuracy (astrometric anomaly problem) is overcome by explicitly including the nearest visible galaxy/satellite in the lens model. However, one anomalous system (RXS J1131-1231) does not show any luminous perturber in its vicinity, and three others (WFI 2026-4536, WFI 2033-4723, and B2045+265) have problematic modeling. These four systems are the best candidates for a pertubation by a dark matter substructure along the line-of-sight; 3) we revisit the correlation between the position angle (PA) and ellipticity of the light and of the mass distribution in lensing galaxies. As in previous studies, we find a significant correlation between the PA of the light and of the mass distributions. However, in contrast with these same studies, we find that the ellipticity of the light and of the mass also correlate well, suggesting that the overall spatial distribution of matter is not very different from the baryon distribution in the inner ~5 kpc of lensing galaxies. This offers a new test for high-resolution hydrodynamical simulations. Based on observations made with the NASA/ESA HST Hubble Space Telescope by the CfA-Arizona Space Telescope Lens Survey (CASTLeS) collaboration, obtained from the data archive at the Space Science Institute, which is operated by AURA, the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS-5-26555. [less ▲]

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See detailA detailed X-ray investigation of ζ Puppis. I. The dataset and some preliminary results
Nazé, Yaël ULg; Flores, C. A.; Rauw, Grégor ULg

in Astronomy and Astrophysics (2012), 538

<BR /> Aims: One of the closest and brightest massive stars, ζ Puppis, was the first early-type object observed by the current generation of X-ray observatories. These observations provided some ... [more ▼]

<BR /> Aims: One of the closest and brightest massive stars, ζ Puppis, was the first early-type object observed by the current generation of X-ray observatories. These observations provided some surprising results, partly confirming the theoretical predictions while simultaneously unveiling some problematic mismatches with expectations. In this series of papers, we perform a thorough study of ζ Puppis in X-rays, using a decade of XMM-Newton observations. <BR /> Methods: The star ζ Puppis was observed 18 times by XMM-Newton, totaling 1 Ms in exposure. This provides the highest quality high-resolution X-ray spectrum of a massive star to date, as well as a perfect dataset for studying X-ray variability in an "archetype" object. <BR /> Results: This first paper reports on the data reduction of this unique dataset and provides a few preliminary results. On the one hand, analysis of EPIC low-resolution spectra shows the star to have a remarkably stable X-ray emission from one observation to the next. On the other hand, fitting by a wind model of individual line profiles recorded by RGS confirms the wavelength dependence of the line morphology. Based on observations collected with XMM-Newton, an ESA Science Mission with instruments and contributions directly funded by ESA Member States and the USA (NASA).Table 1 is available in electronic form at <A href="http://www.aanda.org">http://www.aanda.org</A> [less ▲]

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See detailSolar-like pulsating stars as distance indicators: G-K giants in the CoRoT and Kepler fields
Miglio, A.; Morel, Thierry ULg; Barbieri, M. et al

in European Physical Journal Web of Conferences (2012, February 01)

The detection of radial and non-radial solar-like oscillations in thousands of G-K giants with CoRoT and Kepler is paving the road for detailed studies of stellar populations in the Galaxy. The available ... [more ▼]

The detection of radial and non-radial solar-like oscillations in thousands of G-K giants with CoRoT and Kepler is paving the road for detailed studies of stellar populations in the Galaxy. The available average seismic constraints allow a precise and largely model-independent determination of stellar radii (hence distances) and masses. We here briefly report on the distance determination of thousands of giants in the CoRoT and Kepler fields of view. [less ▲]

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See detailA quantitative study of O stars in NGC 2244 and the Monoceros OB2 association
Martins, F.; Mahy, Laurent ULg; Hillier, D. J. et al

in Astronomy and Astrophysics (2012), 538

<BR /> Aims: Our goal is to determine the stellar and wind properties of seven O stars in the cluster NGC 2244 and three O stars in the OB association Mon OB2. These properties give us insight into the ... [more ▼]

<BR /> Aims: Our goal is to determine the stellar and wind properties of seven O stars in the cluster NGC 2244 and three O stars in the OB association Mon OB2. These properties give us insight into the mass loss rates of O stars. They allow us to both check the validity of rotational mixing in massive stars and to better understand the effects of the ionizing flux and wind mechanical energy release on the surrounding interstellar medium and its influence on triggered star formation. <BR /> Methods: We collected optical and UV spectra of the target stars that we analyzed by means of atmosphere models computed with the code CMFGEN. The spectra of binary stars were disentangled and the components studied separately. <BR /> Results: All stars have an evolutionary age less than 5 million years, with the most massive stars being among the youngest. Nitrogen surface abundances show no clear relation with projected rotational velocities. Binaries and single stars show the same range of enrichment. This is attributed to the youth and/or wide separation of the binary systems in which the components have not (yet) experienced strong interaction. A clear trend toward greater enrichment in higher luminosity objects is observed, consistent with what evolutionary models with rotation predict for a population of O stars at any given age. We confirm the weakness of winds in late O dwarfs. In general, mass loss rates derived from UV lines are lower than mass loss rates obtained from Hα. The UV mass loss rates are even lower than the single-line driving limit in the latest type dwarfs. These issues are discussed in the context of the structure of massive stars winds. The evolutionary and spectroscopic masses are in agreement above 25 M[SUB]&sun;[/SUB], but the uncertainties are large. Below this threshold, the few late-type O stars studied here indicate that the mass discrepancy still seems to hold. Appendix A is available in electronic form at <A href="http://www.aanda.org">http://www.aanda.org</A> [less ▲]

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See detailHigh-resolution X-ray spectroscopy of the magnetic Of?p star HD148937
Nazé, Yaël ULg; Zhekov, S. A.; Walborn, N. R.

in Astrophysical Journal (2012), 746

High-resolution data of the peculiar magnetic massive star HD148937 were obtained with Chandra-HETGS, and are presented here in combination with a re-analysis of the older XMM-RGS data. The lines of the ... [more ▼]

High-resolution data of the peculiar magnetic massive star HD148937 were obtained with Chandra-HETGS, and are presented here in combination with a re-analysis of the older XMM-RGS data. The lines of the high-Z elements (Mg, Si, S) were found to be unshifted and relatively narrow (FWHM of about 800km/s), i.e. narrower than the O line recorded by RGS, which possibly indicates that the hot plasma is multi-thermal and has several origins. These data further indicate a main plasma temperature of about 0.6keV and a formation of the X-ray emission at about one stellar radius above the photosphere. From the spectral fits and the H-to-He line ratios, the presence of very hot plasma is however confirmed, though with a smaller relative strength than for the prototype magnetic oblique rotator $\theta^1$\,Ori\,C. Both stars thus share many similarities, but HD148937 appears less extreme than $\theta^1$\,Ori\,C despite having also a large magnetic confinement parameter. [less ▲]

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See detailMicrolensing Binaries Discovered through High-magnification Channel
Shin, I.-G.; Choi, J.-Y.; Park, S.-Y. et al

in Astrophysical Journal (2012), 746

Microlensing can provide a useful tool to probe binary distributions down to low-mass limits of binary companions. In this paper, we analyze the light curves of eight binary-lensing events detected ... [more ▼]

Microlensing can provide a useful tool to probe binary distributions down to low-mass limits of binary companions. In this paper, we analyze the light curves of eight binary-lensing events detected through the channel of high-magnification events during the seasons from 2007 to 2010. The perturbations, which are confined near the peak of the light curves, can be easily distinguished from the central perturbations caused by planets. However, the degeneracy between close and wide binary solutions cannot be resolved with a 3σ confidence level for three events, implying that the degeneracy would be an important obstacle in studying binary distributions. The dependence of the degeneracy on the lensing parameters is consistent with a theoretical prediction that the degeneracy becomes severe as the binary separation and the mass ratio deviate from the values of resonant caustics. The measured mass ratio of the event OGLE-2008-BLG-510/MOA-2008-BLG-369 is q ~ 0.1, making the companion of the lens a strong brown dwarf candidate. [less ▲]

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See detailProceedings of the 7th International Conference on Si Epitaxy and Heterostructures (ICSI-7)
Hartmann, Jean-Michel; Loo, Roger; Nguyen, Ngoc Duy ULg et al

Book published by Elsevier (2012)

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See detailModelling a high-mass red giant observed by CoRoT
Baudin, F.; Barban, C.; Goupil, M. J. et al

in Astronomy and Astrophysics (2012), 538

Context. The advent of space-borne photometers such as CoRoT and Kepler has opened up new fields in asteroseismology. This is especially true for red giants as only a few of these stars were known to ... [more ▼]

Context. The advent of space-borne photometers such as CoRoT and Kepler has opened up new fields in asteroseismology. This is especially true for red giants as only a few of these stars were known to oscillate with small amplitude, solar-like oscillations before the launch of CoRoT. <BR /> Aims: The G6 giant HR 2582 (HD 50890) was observed by CoRoT for approximately 55 days. We present here the analysis of its light curve and the characterisation of the star using different observables, such as its location in the Hertzsprung-Russell diagram and seismic observables. <BR /> Methods: Mode frequencies are extracted from the observed Fourier spectrum of the light curve. Numerical stellar models are then computed to determine the characteristics of the star (mass, age, etc.) from the comparison with observational constraints. <BR /> Results: We provide evidence for the presence of solar-like oscillations at low frequency, between 10 and 20 μHz, with a regular spacing of (1.7 ± 0.1) μHz between consecutive radial orders. Only radial modes are clearly visible. From the models compatible with the observational constraints used here, We find that HR 2582 (HD 50890) is a massive star with a mass in the range (3-5 M[SUB]&sun;[/SUB]), clearly above the red clump. It oscillates with rather low radial order (n = 5-12) modes. Its evolutionary stage cannot be determined with precision: the star could be on the ascending red giant branch (hydrogen shell burning) with an age of approximately 155 Myr or in a later phase (helium burning). In order to obtain a reasonable helium amount, the metallicity of the star must be quite subsolar. Our best models are obtained with a mixing length significantly smaller than that obtained for the Sun with the same physical description (except overshoot). The amount of core overshoot during the main-sequence phase is found to be mild, of the order of 0.1 H[SUB]p[/SUB]. <BR /> Conclusions: HR 2582 (HD 50890) is an interesting case as only a few massive stars can be observed due to their rapid evolution compared to less massive red giants. HR 2582 (HD 50890) is also one of the few cases that can be used to validate the scaling relations for massive red giants stars and its sensitivity to the physics of the star. The CoRoT space mission, launched on 2006 December 27, was developed and is operated by the CNES with participation of the Science Programs of ESA; ESA's RSSD, Austria, Belgium, Brazil, Germany and Spain. [less ▲]

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See detailTransiting exoplanets from the CoRoT space mission Resolving the nature of transit candidates for the LRa03 and SRa03 fields
Cavarroc, C.; Moutou, C.; Gandolfi, D. et al

in Astrophysics & Space Science (2012), 337

CoRoT is a space telescope which aims at studying internal structure of stars and detecting extrasolar planets. We present here a list of transits detected in the light curves of stars observed by CoRoT ... [more ▼]

CoRoT is a space telescope which aims at studying internal structure of stars and detecting extrasolar planets. We present here a list of transits detected in the light curves of stars observed by CoRoT in two fields in the anti-center direction: the LRa03 one observed during 148 days from 3 October 2009 to 1 March 2010 followed by the SRa03 one from the 5 March 2010 to the 29 March 2010 during 25 days. 5329 light curves for the LRa03 field and 4169 for the SRa03 field were analyzed by the detection team of CoRoT. Then some of the selected exoplanetary candidates have been followed up from the ground. In the LRa03 field, 19 exoplanet candidates have been found, 8 remain unsolved. No secured planet has been found yet. In the SRa03 field, there were 11 exoplanetary candidates among which 6 cases remain unsolved and 3 planets have been found: CoRoT-18b, CoRoT-19b, CoRoT-20b. [less ▲]

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See detailLa production de viande par les bovins
Beckers, Yves ULg

Conference given outside the academic context (2012)

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See detailTraitement à la source d'eaux usées hospitalières par boues activées: faisabilité et impact sur la biomasse
Alrhmoun, Moussab; Louvet, Jean-Noël ULg; Stalder, Thibault et al

Conference (2012, February 01)

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