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See detailAnalysis of tobacco mainstream smoke by GC×GC TOFMS
Brokl, Michal ULg; Bishop, Louise; Wright, Christopher et al

Poster (2012, March)

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See detailThe instability strip of ZZ Ceti white dwarfs I. Introduction of time-dependent convection
Van Grootel, Valérie ULg; Dupret, Marc-Antoine ULg; Fontaine, Gilles et al

in Astronomy and Astrophysics (2012), 539

Aims. The determination of the location of the theoretical ZZ Ceti instability strip in the log g − Teff diagram has remained a challenge over the years due to the lack of a suitable treatment for ... [more ▼]

Aims. The determination of the location of the theoretical ZZ Ceti instability strip in the log g − Teff diagram has remained a challenge over the years due to the lack of a suitable treatment for convection in these stars. For the first time, a full nonadiabatic approach including time-dependent convection is applied to ZZ Ceti pulsators, and we provide the appropriate details related to the inner work- ings of the driving mechanism at work. Methods. We used the nonadiabatic pulsation code MAD with a representative evolutionary sequence of a 0.6 M⊙ DA white dwarf. This sequence is made of state-of-the-art models that include a detailed modeling of the feedback of convection on the atmospheric structure. The assumed convective efficiency in these models is the so-called ML2/α = 1.0 version. We also carried out, for comparison purposes, nonadiabatic computations within the frozen convection approximation, as well as calculations based on models with standard grey atmospheres. Results. We find that pulsational driving in ZZ Ceti stars is concentrated at the base of the superficial H convection zone, but at depths, near the blue edge of the instability strip, somewhat larger than those obtained with the frozen convection approach. Despite the fact that this approach is formally invalid in such stars, particularly near the blue edge of the instability strip, the predicted boundaries are not dramatically different in both cases. The revised blue edge for a 0.6 M⊙ model is found to be around Teff = 11,970 K, some 240 K hotter than the value predicted within the frozen convection approximation, in rather good agreement with the empirical value. On the other hand, our predicted red edge temperature for the same stellar mass is only about 5600 K (80 K hotter than with the frozen convection approach), much lower than the observed value. Conclusions. We correctly understand the development of pulsational instabilities of a white dwarf as it cools at the blue edge of the ZZ Ceti instability strip. Our current implementation of time-dependent convection however still lacks important ingredients to fully account for the observed red edge of the strip. We will explore a number of possibilities in the future papers of this series. [less ▲]

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See detailFacebook et l'entrepreneuriat féminin
Cornet, Annie ULg

Learning material (2012)

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See detailStrontium ranelate reduces the number of radiological or radioclinical progressors in patients with primary knee osteoarthritis
Reginster, Jean-Yves ULg; Chapurlat, R; Christiansen, C et al

in Osteoporosis International (2012, March), 23(S2), 366-367

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See detailTi alloys processed by selective laser melting and by laser cladding: microstructures and mechanical properties
Mertens, Anne ULg; Contrepois, Quentin ULg; Dormal, Thierry ULg et al

in proceedings of 12th EUROPEAN CONFERENCE ON SPACECRAFT STRUCTURES, MATERIALS & ENVIRONMENTAL TESTING, Noordwijk 20-23 mars 2012 (2012, March)

Selective laser melting (SLM) and laser cladding were developed in the late 1990s as economic layer-by-layer near-net-shape processes allowing for the production – and also, in the case of laser cladding ... [more ▼]

Selective laser melting (SLM) and laser cladding were developed in the late 1990s as economic layer-by-layer near-net-shape processes allowing for the production – and also, in the case of laser cladding, the restoration - of complex parts. Both techniques involve the melting of a metallic powder with a laser. In the case of SLM, the metallic powder is deposited layer by layer and then molten locally according to the desired shape, whereas in laser cladding the metallic powder is projected onto a substrate through a tube coaxial with the laser. In both processes, the metallic melt pools then cool down and solidify very rapidly, thus producing strongly out of equilibrium microstructures that might exhibit high internal stresses. In the present work, efforts have been made to enhance the flexibility of the laser cladding process: a second laser with a maximum power of 300W was installed beside the original laser (with a higher maximum power of 2000W), thus allowing for the processing of parts with thinner walls and/or coatings. Moreover, flexibility was also improved in relation with the geometry of the parts by use of a 5-axes displacement control. Samples of alloy Ti-6Al-4V, that is widely used in the aeronautic industry due to its high specific strength, have been processed both by SLM and by laser cladding. The resulting microstructures have been characterised in details by optical microscopy, SEM and EBSD so as to allow for a better understanding of the solidification process and of the subsequent phase transformations taking place upon cooling for both techniques. The influence of processing parameters such as the orientation of the deposition of the successive powder layers on the mechanical properties was also investigated by means of uniaxial tensile testing performed on samples with different deposition orientations in regard to the direction of mechanical solicitation. Moreover, some of the samples for mechanical testing had undergone an annealing treatment at 640°C for 4 hours to relieve internal stresses, in order to assess more precisely the effect of those stresses on the tensile properties. [less ▲]

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See detailAu-delà des limites. Focus sur quatre maisons d’édition alternatives bruxelloises
Paques, Frédéric ULg

in Lectures : La Revue des Bibliothèques (2012), 175

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See detailHeisenberg-limited Metrology without Entanglement
Braun, Daniel; Martin, John ULg

in Research in Optical Sciences, OSA Technical Digest (2012)

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See detailComment s’en sortent-ils ?
Etienne, Anne-Marie ULg

Article for general public (2012)

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See detailRELIABILITY OF ANALYTICAL METHODS’ RESULTS: A BAYESIAN APPROACH TO ANALYTICAL METHOD VALIDATION
Rozet, Eric ULg; Govaerts, B.; Lebrun, Pierre ULg et al

Conference (2012, March)

Methods validation is mandatory in order to assess the fitness of purpose of the developed analytical method. Of core importance at the end of the validation is the evaluation of the reliability of the ... [more ▼]

Methods validation is mandatory in order to assess the fitness of purpose of the developed analytical method. Of core importance at the end of the validation is the evaluation of the reliability of the individual results that will be generated during the routine application of the method. Regulatory guidelines provide a general framework to assess the validity of a method, but none address the issue of results reliability. In this study, a Bayesian approach is proposed to address this concern. Results reliability is defined here as “the probability ()π of an analytical method to provide analytical results within predefined acceptance limits ()X()λ± around their reference or conventional true concentration values ()Tμ over a defined concentration range and under given environmental and operating conditions.” By providing the minimum reliability probability (minπ needed for the subsequent routine application of the method, as well as specifications or acceptance limits ()λ±, the proposed Bayesian approach provides the effective probability of obtaining reliable future analytical results over the whole concentration range investigated. This is summarized in a single graph: the reliability profile. This Bayesian reliability profile is also compared to two frequentist approaches, the first one derived from the work of Dewé et al. [1] and the second proposed by Govaerts et al. [2]. Furthermore, the applicability of the Bayesian reliability profile is shown using as example the validation of a bioanalytical method dedicated to the determination of ketoglutaric acid (KG) and hydroxymethylfurfural (HMF) in human plasma by SPE-HPLC-UV. [1] Dewé W., Govaerts B., Boulanger B., Rozet E., Chiap P., Hubert Ph., Chemometr. Intell. Lab. Syst. 85 (2007) 262-268. [2] B. Govaerts, W. Dewé, M. Maumy, B. Boulanger, Qual. Reliab. Engng. Int. 24 (2008) 667-680. [less ▲]

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See detailStrontium ranelate and risk of venous thromboembolism (VTE) : an update of a retrospective cohort study in the UK general practice research database (GPRD)
Cooper, C; Deltour, N; Speirs, C et al

in Osteoporosis International (2012, March), 23(S2), 364-365

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See detailVers une politique active du patrimoine dans le SDER nouveau
Fisher, Axel ULg; Goossens, Marc ULg; Occhiuto, Rita ULg et al

in Cahiers Nouveaux (Les) (2012), 81

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See detailIncidence of Abcd1 level on the induction of cell death and organelle dysfunctions triggered by very long chain fatty acids and TNF-alpha on oligodendrocytes and astrocytes
Baarine, Mauhamad; Ragot, Kevin; Athias, Anne et al

in NeuroToxicology (2012), 33(2)

X-linked adrenoleukodystrophy (X-ALD) is characterized by ABCD1 deficiency. This disease is associated with elevated concentrations of very long chain fatty acids (C24:0 and C26:0) in the plasma and ... [more ▼]

X-linked adrenoleukodystrophy (X-ALD) is characterized by ABCD1 deficiency. This disease is associated with elevated concentrations of very long chain fatty acids (C24:0 and C26:0) in the plasma and tissues of patients. Under its severe form, brain demyelination and inflammation are observed. Therefore, we determined the effects of C24:0 and C26:0 on glial cells:oligodendrocytes, which synthesize myelin, and astrocytes, which participate in immune response. So, 158N murine oligodendrocytes, rat C6 glioma cells, rat primary cultures of neuronal–glial cells, and of oligodendrocytes were treated for various periods of time in the absence or presence of C24:0 and C26:0 used at plasmatic concentrations found in X-ALD patients (1–5 μM) and higher (10, 20, 40 μM). To evaluate the importance of extrinsic and intrinsic factors, the part taken by TNF-α and reduced Abcd1 level was studied. Whatever the cells considered, no effects on cell growth and/or viability were detected at 1–5 μM, more or less pronounced effects were identified at 10 μM, and an induction of cell death with increased permeability to propidium iodide and loss of transmembrane mitochondrial potential was observed at 20–40 μM. On 158N, cell death was characterized by (i) an increased superoxide anion production at the mitochondrial level; (ii) the presence of vacuoles of different sizes and shapes; a destabilization of lysosomal membrane and a cytoplasmic redistribution of lysosomes; (iii) a modulation of Abcd3/PMP70 and Acox-1 protein expression, and a decrease in catalase activity at the peroxisomal level. When TNF-α was combined with C24:0 or C26:0 and used on 158N cells, C6 cells, and on 158N cells after siRNA mediated knockdown of Abcd1, no or slight potentiation was revealed. Thus, on the different cell models used, an induction of cell death with marked cellular dysfunctions at the mitochondrial, lysosomal, and peroxisomal levels were found with C24:0 and C26:0 at 20 μM and higher. However, in our experimental conditions, plasmatic concentrations of these fatty acids were unable to induce cell death, and organelle dysfunctions on oligodendrocytes and astrocytes, and additional intrinsic and environmental factors, such as reduced Abcd1 level and/or TNF-α, were ineffective to potentiate their side effects. [less ▲]

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See detailWhat are the most important medication attributes for patients with osteoporosis ? Results from a qualitative study
Hiligsmann, Mickaël ULg; Van Durme, C; Geusens, P et al

in Osteoporosis International (2012, March), 23(S2), 81-82

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See detailModellierung des Trennverhaltens wässriger Systeme in Packungskolonnen basierend auf tomographischen
Janzen, Anna; Steube, Julia; Aferka, Saïd ULg et al

Conference (2012, March)

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See detailCharacterization of synovial angiogenesis in osteoarthritis patients and its modulation by chondroitin sulfate
Lambert, Cécile ULg; Mathy-Hartert, Marianne; Dubuc, JE et al

in Arthritis Research & Therapy (2012), 14(2), 58

INTRODUCTION: This work aimed at comparing the production of inflammatory and pro- and anti-angiogenic factors by normal/reactive (N/R) or inflammatory (I) areas of the osteoarthritic synovial membrane ... [more ▼]

INTRODUCTION: This work aimed at comparing the production of inflammatory and pro- and anti-angiogenic factors by normal/reactive (N/R) or inflammatory (I) areas of the osteoarthritic synovial membrane. The effects of interleukin (IL)-1β and chondroitin sulfate (CS) on the expression of pro- and anti-angiogenic factors by synovial fibroblasts cells (SFC) were also studied. METHODS: Biopsies from N/R or from I areas of osteoarthritic synovial membrane were collected at the time of surgery. The inflammatory status of the synovial membrane was characterized by the surgeon according to macroscopic criteria, including the synovial vascularization, the villi formation and the hypertrophic aspect of the tissue. We assessed the expression of CD45, von Willebrand factor and vascular endothelial growth factor (VEGF) antigen by immunohistochemistry in both N/R and I biopsies. The production of IL-6, -8, VEGF and thrombospondin (TSP)-1 by N/R or I synovial cells was quantified by ELISA. SFC were cultured in the absence or in the presence of IL-1β (1 ng/ml) and with or without CS (10, 50, 200 μg/ml). Gene expression of pro-angiogenic factors (VEGF, basic fibroblast growth factor (bFGF), nerve growth factor (NGF), matrix metalloproteinase (MMP)-2 and angiopoietin (ang)-1) and anti-angiogenic factors (vascular endothelial growth inhibitor (VEGI), TSP-1 and -2) were determined by real time RT-PCR. Production of VEGI and TSP-1 was also estimated by ELISA. RESULTS: Immunohistochemistry showed the increase of lymphocyte infiltration, vascular density and VEGF expression in I compared to N/R synovial biopsies. Synovial cells from I areas produced more IL-6, IL-8 and VEGF but less TSP-1 than cells isolated from N/R synovial biopsies. The expression of pro-angiogenic factors by SFC was stimulated by IL-1β. A time dependent regulation of the expression of anti-angiogenic factor genes was observed. IL-1β stimulated the expression of anti-angiogenic factor genes but inhibited it after 24 h. CS reversed the inhibitory effect of IL-1β on anti-angiogenic factors, VEGI and TSP-1. CONCLUSIONS: We demonstrated that synovial biopsies from I areas expressed a pro-angiogenic phenotype. IL-1β induced an imbalance between pro- and anti-angiogenic factors in SFC and CS tended to normalize this IL-1β-induced imbalance, providing a new possible mechanism of action of this drug. [less ▲]

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See detailEffect of collagen hydrolysate in articular pain: A 6-month randomized, double-blind, placebo controlled study
Bruyère, Olivier ULg; Zegels, Brigitte ULg; LEONORI, Lorenzo ULg et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 362-363

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See detailPerception, knowledge and use by general practitioners of Belgium of the FRAX tool
Bruyère, Olivier ULg; Nicolet, Delphine ULg; Compère, Stéphanie et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 363-364

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