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See detailIncidence of Abcd1 level on the induction of cell death and organelle dysfunctions triggered by very long chain fatty acids and TNF-alpha on oligodendrocytes and astrocytes
Baarine, Mauhamad; Ragot, Kevin; Athias, Anne et al

in NeuroToxicology (2012), 33(2)

X-linked adrenoleukodystrophy (X-ALD) is characterized by ABCD1 deficiency. This disease is associated with elevated concentrations of very long chain fatty acids (C24:0 and C26:0) in the plasma and ... [more ▼]

X-linked adrenoleukodystrophy (X-ALD) is characterized by ABCD1 deficiency. This disease is associated with elevated concentrations of very long chain fatty acids (C24:0 and C26:0) in the plasma and tissues of patients. Under its severe form, brain demyelination and inflammation are observed. Therefore, we determined the effects of C24:0 and C26:0 on glial cells:oligodendrocytes, which synthesize myelin, and astrocytes, which participate in immune response. So, 158N murine oligodendrocytes, rat C6 glioma cells, rat primary cultures of neuronal–glial cells, and of oligodendrocytes were treated for various periods of time in the absence or presence of C24:0 and C26:0 used at plasmatic concentrations found in X-ALD patients (1–5 μM) and higher (10, 20, 40 μM). To evaluate the importance of extrinsic and intrinsic factors, the part taken by TNF-α and reduced Abcd1 level was studied. Whatever the cells considered, no effects on cell growth and/or viability were detected at 1–5 μM, more or less pronounced effects were identified at 10 μM, and an induction of cell death with increased permeability to propidium iodide and loss of transmembrane mitochondrial potential was observed at 20–40 μM. On 158N, cell death was characterized by (i) an increased superoxide anion production at the mitochondrial level; (ii) the presence of vacuoles of different sizes and shapes; a destabilization of lysosomal membrane and a cytoplasmic redistribution of lysosomes; (iii) a modulation of Abcd3/PMP70 and Acox-1 protein expression, and a decrease in catalase activity at the peroxisomal level. When TNF-α was combined with C24:0 or C26:0 and used on 158N cells, C6 cells, and on 158N cells after siRNA mediated knockdown of Abcd1, no or slight potentiation was revealed. Thus, on the different cell models used, an induction of cell death with marked cellular dysfunctions at the mitochondrial, lysosomal, and peroxisomal levels were found with C24:0 and C26:0 at 20 μM and higher. However, in our experimental conditions, plasmatic concentrations of these fatty acids were unable to induce cell death, and organelle dysfunctions on oligodendrocytes and astrocytes, and additional intrinsic and environmental factors, such as reduced Abcd1 level and/or TNF-α, were ineffective to potentiate their side effects. [less ▲]

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See detailEstablishment of parathyroid hormone (PTH) reference on 10 different assay kits: impact of the recruitment of the population
CAVALIER, Etienne ULg; SOUBERBIELLE, Jean-Claude

in Osteoporosis International (2012, March), 23(Supplement 2), 360

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See detailSome Applications of Mathematical Statistics in Management
Heuchenne, Cédric ULg

Scientific conference (2012, March)

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See detailDifference between total and intact assays for N-terminal propeptide of type I procollagen in renal impaired patients
CAVALIER, Etienne ULg; CARLISI, Ignazia ULg; ROUSSELLE, Olivier ULg et al

in Osteoporosis International (2012, March), 23(Supplement 2), 339

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See detailUn pôle d'excellence wallon en santé articulaire.
Henrotin, Yves ULg

Article for general public (2012)

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See detailMrs Gandhi's Final Term and the Remaking of the Congress (I)'s Social Base
Maiorano, Diego ULg

in India Review (2012), 11(1),

This article examines the impact that national economic policies adopted during Indira Gandhi's final term in office (1980–84) had on four “national” social groups, namely the big industrialists, the ... [more ▼]

This article examines the impact that national economic policies adopted during Indira Gandhi's final term in office (1980–84) had on four “national” social groups, namely the big industrialists, the middle class, the rich peasantry, and the poor. The study argues that the Congress (I) chose the former two as its major allies, while the rich peasantry and the poor were relegated to a secondary position. In the process, the focus of India's strategy of development shifted from the agrarian to the industrial sector, and from the rural to the urban world. [less ▲]

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See detailDe la pédagogie au théâtre documentaire. Entretien avec Françoise Bloch
Delhalle, Nancy ULg

in Alternatives Théâtrales (2012), (112),

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See detailL’Inventaire Systémique de Qualité de vie pour Adolescents (ISQV-A) : qualités psychométriques et application clinique
Etienne, Anne-Marie ULg; Missotten, Pierre ULg; Dupuis, Gilles

in Revue Francophone de Clinique Comportementale et Cognitive (2012), XVII(1), 44-56

Purpose: The objective was to determine the psychometric properties and the clinical application of a new Quality of Life self-assessment questionnaire suitable for adolescents 13 to 18 years old: the ... [more ▼]

Purpose: The objective was to determine the psychometric properties and the clinical application of a new Quality of Life self-assessment questionnaire suitable for adolescents 13 to 18 years old: the “Inventaire Systémique de Qualité de vie pour Adolescents” (ISQV-A). Methods: This was a cross-sectional validation study. 171 French adolescents have completed the ISQV-A. Other tools were used: the State-Trait Anxiety Inventory for Children (STAIC), the Children’s Depression Inventory (CDI). Results: The internal consistency of the four indices of the ISQV-A (state, goal, rank and gap) is satisfactory. All scores have their own specificity. The data show the convergent validity, test-retest fidelity and applicability of the ISQV-A. Conclusions: The adequacy of this new tool seems evident to highlight the adolescent’s quality of life. We will also discuss its clinical relevance into a cognitive behavioural approach. [less ▲]

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See detailThe birth of the Belgian Network for Science, Technology and Society (BSTS Network)
Delvenne, Pierre ULg; Thoreau, François ULg

in EASST Review (2012), 31(1), 9-12

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See detailIndirect comparison of bazedoxifene vs. oral bisphosphonates for the prevention of nonvertebral fractures in high-risk postmenopausal osteoporosis population
Ellis, A; Jansen, J; Luo, X et al

in Osteoporosis International (2012, March), 23(S2), 64-65

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See detailL’Inventaire Systémique de Qualité de Vie pour Personnes Agées (ISQV-65+©) : premiers éléments de validation
Missotten, Pierre ULg; Ylieff, Michel ULg; Etienne, Anne-Marie ULg et al

in Revue Francophone de Clinique Comportementale et Cognitive (2012), XVII(1), 69-82

This article discusses the measurement of quality of life for old people through the preliminary validation study (applicability, reliability and validity) of a questionnaire specifically designed for ... [more ▼]

This article discusses the measurement of quality of life for old people through the preliminary validation study (applicability, reliability and validity) of a questionnaire specifically designed for this population: the Quality of Life Systemic Inventory for old people (QLSI-65+©). This validation is based on a sample of 54 non-institutionalized adults aged 65 to 85 years. All completed a sociodemographic and medical questionnaire, the QLSI-65+©, the Geriatric Depression Scale (GDS) and the Satisfaction with Life Scale (SWLS). The results show a good applicability of the QLSI-65+©. The internal consistency of the indices (State, Goal, Rank and Gap) is very satisfactory. All indices are correlated each other to varying degrees (reliability). Correlations between State, Goal and Gap QLSI-65+© global scores and GDS and SWLS total scores are significant (convergent validity). Finally, State, Goal and Gap QLSI-65+© global scores of the sample are significantly better than those of 17 informal caregivers of people with dementia (validity in terms of know group differences). [less ▲]

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See detailSeverity of incident vertebral fracture and future fracture risk: a 3-year prospective study
Bruyère, Olivier ULg; Roux, Christian; Nicolet, Delphine ULg et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 60-61

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See detailLa libre circulation des personnes dans et vers l'Union européenne: année 2011
Carlier, Jean-Yves ULg

in Journal de Droit Européen [=JDE] (2012), 20(187), 85-92

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See detailSpécificités de la proprioception de l’épaule
Forthomme, Bénédicte ULg; Kaux, Jean-François ULg; Crielaard, Jean-Michel ULg et al

in Julia, M.; Hirt, D.; Perrey, S. (Eds.) et al La proprioception (2012)

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See detailAnalyse des mécanismes de transfert de fluides lors d'essais de séchage convectif sur un limon
Gerard, Pierre ULg; Léonard, Angélique ULg; Charlier, Robert ULg et al

in Skoczykas, Frédéric; Davy, Catherine; Agostini, Franck (Eds.) et al Actes du colloque Transfert 2012 - Propriétés de transfert des géomatériaux (2012, March)

Des essais de séchage convectif ont été réalisés sur des échantillons de limon en vue de quantifier la cinétique de perte de masse. Ces essais ont été analysés sous l’hypothèse de l’existence d’une couche ... [more ▼]

Des essais de séchage convectif ont été réalisés sur des échantillons de limon en vue de quantifier la cinétique de perte de masse. Ces essais ont été analysés sous l’hypothèse de l’existence d’une couche limite en paroi de l’échantillon, dans laquelle des transferts de masse et de chaleur ont lieu. L’article met en avant l’intérêt de modélisations thermo-hydrauliques pour comprendre les transferts de fluides au sein de l’échantillon. Une analyse précise des résultats numériques permet de déterminer si les transferts internes sont constitués principalement d’advection d’eau liquide jusqu’à la paroi suivi par de l’évaporation, ou plutôt de l’avancée d’un front d’évaporation au sein de l’échantillon suivi par de la diffusion de la vapeur jusqu’à la paroi. [less ▲]

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See detailUne approche modulaire d’évaluation de la qualité de vie en oncologie pédiatrique : les versions française et portugaise de l’Inventaire Systémique de Qualité de Vie pour Enfants (ISQV-E©)
Missotten, Pierre ULg; Fonseca, Marta; Dupuis, Gilles et al

in Revue Francophone de Clinique Comportementale et Cognitive (2012), XVII(1), 15-33

This study approaches the question of quality of life measure in paediatric oncology. The main aim is to compare the quality of life level of children (8-12 years) undergoing (T) and off (HT) oncological ... [more ▼]

This study approaches the question of quality of life measure in paediatric oncology. The main aim is to compare the quality of life level of children (8-12 years) undergoing (T) and off (HT) oncological treatments by using the French and the Portuguese modular versions of the Child Quality of Life Systemic Inventory (QLSI-C©). The Portuguese sample consists of 26 children T and 14 HT while the Belgian sample includes 20 children T and 35 HT. Results demonstrate statistically significant differences between the T and HT groups, particularly for the French version of the QLSI-C©. They also give evidence of the influence of some clinical and sociodemographic variables on the global quality of life score, mainly for the Portuguese version of the QLSI-C©. In conclusion, findings demonstrate the clinical interest of French and Portuguese versions of the QLSI-C© and their capacity to distinguish children undergoing oncological treatments from children off these treatments. [less ▲]

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See detailNeurosurgery for headaches
MAGIS, Delphine ULg

Conference (2012, March)

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See detailTreatment of a severe distal forelimb wound presenting with extensive laceration and distal interphalangeal joint luxation in a donkey
Brogniez, L; Launois,T; Perrin R et al

in Pferdeheilkunde (2012), 28(2), 160-166

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