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See detailStrontium ranelate reduces the number of radiological or radioclinical progressors in patients with primary knee osteoarthritis
Reginster, Jean-Yves ULg; Chapurlat, R; Christiansen, C et al

in Osteoporosis International (2012, March), 23(S2), 366-367

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See detailAu-delà des limites. Focus sur quatre maisons d’édition alternatives bruxelloises
Paques, Frédéric ULg

in Lectures : La Revue des Bibliothèques (2012), 175

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See detailRELIABILITY OF ANALYTICAL METHODS’ RESULTS: A BAYESIAN APPROACH TO ANALYTICAL METHOD VALIDATION
Rozet, Eric ULg; Govaerts, B.; Lebrun, Pierre ULg et al

Conference (2012, March)

Methods validation is mandatory in order to assess the fitness of purpose of the developed analytical method. Of core importance at the end of the validation is the evaluation of the reliability of the ... [more ▼]

Methods validation is mandatory in order to assess the fitness of purpose of the developed analytical method. Of core importance at the end of the validation is the evaluation of the reliability of the individual results that will be generated during the routine application of the method. Regulatory guidelines provide a general framework to assess the validity of a method, but none address the issue of results reliability. In this study, a Bayesian approach is proposed to address this concern. Results reliability is defined here as “the probability ()π of an analytical method to provide analytical results within predefined acceptance limits ()X()λ± around their reference or conventional true concentration values ()Tμ over a defined concentration range and under given environmental and operating conditions.” By providing the minimum reliability probability (minπ needed for the subsequent routine application of the method, as well as specifications or acceptance limits ()λ±, the proposed Bayesian approach provides the effective probability of obtaining reliable future analytical results over the whole concentration range investigated. This is summarized in a single graph: the reliability profile. This Bayesian reliability profile is also compared to two frequentist approaches, the first one derived from the work of Dewé et al. [1] and the second proposed by Govaerts et al. [2]. Furthermore, the applicability of the Bayesian reliability profile is shown using as example the validation of a bioanalytical method dedicated to the determination of ketoglutaric acid (KG) and hydroxymethylfurfural (HMF) in human plasma by SPE-HPLC-UV. [1] Dewé W., Govaerts B., Boulanger B., Rozet E., Chiap P., Hubert Ph., Chemometr. Intell. Lab. Syst. 85 (2007) 262-268. [2] B. Govaerts, W. Dewé, M. Maumy, B. Boulanger, Qual. Reliab. Engng. Int. 24 (2008) 667-680. [less ▲]

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See detailStrontium ranelate and risk of venous thromboembolism (VTE) : an update of a retrospective cohort study in the UK general practice research database (GPRD)
Cooper, C; Deltour, N; Speirs, C et al

in Osteoporosis International (2012, March), 23(S2), 364-365

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See detailModèles d'écoulements incompressibles en plan vertical appliqués aux structures du génie civil
Detrembleur, Sylvain ULg

Doctoral thesis (2012)

Le travail entrepris s’intègre complètement dans la filière d’étude propre au HACH, à savoir une interaction étroite entre modèles numériques et validation sur bases d’éléments issus de la modélisation ... [more ▼]

Le travail entrepris s’intègre complètement dans la filière d’étude propre au HACH, à savoir une interaction étroite entre modèles numériques et validation sur bases d’éléments issus de la modélisation physique. Les hypothèses restrictives du modèle intégré sur la hauteur (WOLF2D) ont été gommées par l’ajout de deux nouveaux modules permettant de calculer explicitement la distribution des variables hydrodynamiques sur la hauteur de l’écoulement. L’utilisation intensive du code bidimensionnel horizontal et les modélisations diverses et variées menées au moyen de ce module ont conduit à de nombreuses implémentations nouvelles dans ce code, permettant de traiter un nombre grandissant de situations complexes. L’utilisation d’un maillage structuré, même différentiable spatialement au moyen d’une technique multiblocs, ne permet cependant pas à l’utilisateur de représenter adéquatement certaines géométries complexes. Il ressort de ce constat que les techniques numériques à même de supprimer cette dépendance ont fait l’objet d’une partie de cette recherche, en permettant l’utilisation de contours quelconques qui ne respectent pas nécessairement la structure cartésienne du maillage. Ces développements ont tout naturellement conduit à la modélisation d’interactions de structures solides sur le fluide. D’autre part, le grand nombre de modèles hydrodynamiques spécifiques implémentés dans le code WOLF2D trahissent une volonté d’intégrer les variations verticales des composantes hydrodynamiques agglomérées par l’intégration sur la hauteur. Ces distributions peuvent, certes, être maîtrisées dans une certaine mesure, mais ne peuvent en aucun cas reproduire la dynamique complexe qui est observée dans la direction d’intégration de ce type de modèle. Par conséquent, la partie principale des recherches entreprises dans cette thèse est concentrée sur le développement d’un modèle bidimensionnel explicitement discrétisé sur la verticale (WOLF2DV) qui permet de combler le manque d’informations distribuées induit lors de l’élaboration d’un modèle bidimensionnel horizontal. L’obtention de ces informations a cependant un coût, puisque la structure et la technique de résolution du système d’équations est différente des modèles intégrés sur la hauteur ou sur la section et engendre des coûts de calcul supplémentaires. Afin de conserver la philosophie générale de la suite logicielle WOLF, qui se veut polyvalente et efficace même sur de grandes applications réelles, un effort considérable a été consenti lors de l’évaluation des techniques de résolution et de leur implémentation et ce, afin de conserver des temps de calcul acceptables. En outre, la volonté de s’affranchir de la discrétisation sur des maillages structurés transparaît également au niveau des recherches entreprises pour ce code explicitement discrétisé sur la verticale puisqu’un second challenge important a consisté en l’élaboration d’une technique de suivi d’interface adaptée. Finalement, les résultats probants et prometteurs fournis ont amené tout naturellement à étendre ce module bidimensionnel vers la troisième dimension et à ainsi représenter explicitement un écoulement tridimensionnel (WOLF3D). Compte tenu de la lourdeur de développement dans la troisième dimension, ce module est limité aux écoulements sous pression et constitue la base de recherches futures qui viseront à adjoindre à ce code une gestion de surface libre ou encore des modèles de turbulence. [less ▲]

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See detailVers une politique active du patrimoine dans le SDER nouveau
Fisher, Axel ULg; Goossens, Marc ULg; Occhiuto, Rita ULg et al

in Cahiers Nouveaux (Les) (2012), 81

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See detailSport (and Exercise) Pedagogy and its interest in the fields of PE teaching, sport coaching and physical activity/health
Cloes, Marc ULg

Conference (2012, March)

Within the specialist seminar, the aims of this presentation were to share a personal conception of Sport (& Exercise) Pedagogy, to illustrate some current challenges for researchers of this specific ... [more ▼]

Within the specialist seminar, the aims of this presentation were to share a personal conception of Sport (& Exercise) Pedagogy, to illustrate some current challenges for researchers of this specific field of Sport Sciences, and to suggest some approaches to develop in the future. In the first part, an emphasis will be set on the analysis of the papers presented during the ARIS' congresses. It will be the opportunity to bridge the gap between Anglo-Saxon authors and those from the French speaking world, in order to underline the existence of a research corpus that is unknown by those who are not able to read another language than English. [less ▲]

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See detailWhat are the most important medication attributes for patients with osteoporosis ? Results from a qualitative study
Hiligsmann, Mickaël ULg; Van Durme, C; Geusens, P et al

in Osteoporosis International (2012, March), 23(S2), 81-82

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See detailCharacterization of synovial angiogenesis in osteoarthritis patients and its modulation by chondroitin sulfate
Lambert, Cécile ULg; Mathy-Hartert, Marianne; Dubuc, JE et al

in Arthritis Research & Therapy (2012), 14(2), 58

INTRODUCTION: This work aimed at comparing the production of inflammatory and pro- and anti-angiogenic factors by normal/reactive (N/R) or inflammatory (I) areas of the osteoarthritic synovial membrane ... [more ▼]

INTRODUCTION: This work aimed at comparing the production of inflammatory and pro- and anti-angiogenic factors by normal/reactive (N/R) or inflammatory (I) areas of the osteoarthritic synovial membrane. The effects of interleukin (IL)-1β and chondroitin sulfate (CS) on the expression of pro- and anti-angiogenic factors by synovial fibroblasts cells (SFC) were also studied. METHODS: Biopsies from N/R or from I areas of osteoarthritic synovial membrane were collected at the time of surgery. The inflammatory status of the synovial membrane was characterized by the surgeon according to macroscopic criteria, including the synovial vascularization, the villi formation and the hypertrophic aspect of the tissue. We assessed the expression of CD45, von Willebrand factor and vascular endothelial growth factor (VEGF) antigen by immunohistochemistry in both N/R and I biopsies. The production of IL-6, -8, VEGF and thrombospondin (TSP)-1 by N/R or I synovial cells was quantified by ELISA. SFC were cultured in the absence or in the presence of IL-1β (1 ng/ml) and with or without CS (10, 50, 200 μg/ml). Gene expression of pro-angiogenic factors (VEGF, basic fibroblast growth factor (bFGF), nerve growth factor (NGF), matrix metalloproteinase (MMP)-2 and angiopoietin (ang)-1) and anti-angiogenic factors (vascular endothelial growth inhibitor (VEGI), TSP-1 and -2) were determined by real time RT-PCR. Production of VEGI and TSP-1 was also estimated by ELISA. RESULTS: Immunohistochemistry showed the increase of lymphocyte infiltration, vascular density and VEGF expression in I compared to N/R synovial biopsies. Synovial cells from I areas produced more IL-6, IL-8 and VEGF but less TSP-1 than cells isolated from N/R synovial biopsies. The expression of pro-angiogenic factors by SFC was stimulated by IL-1β. A time dependent regulation of the expression of anti-angiogenic factor genes was observed. IL-1β stimulated the expression of anti-angiogenic factor genes but inhibited it after 24 h. CS reversed the inhibitory effect of IL-1β on anti-angiogenic factors, VEGI and TSP-1. CONCLUSIONS: We demonstrated that synovial biopsies from I areas expressed a pro-angiogenic phenotype. IL-1β induced an imbalance between pro- and anti-angiogenic factors in SFC and CS tended to normalize this IL-1β-induced imbalance, providing a new possible mechanism of action of this drug. [less ▲]

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See detailEffect of collagen hydrolysate in articular pain: A 6-month randomized, double-blind, placebo controlled study
Bruyère, Olivier ULg; Zegels, Brigitte ULg; LEONORI, Lorenzo ULg et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 362-363

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See detailPerception, knowledge and use by general practitioners of Belgium of the FRAX tool
Bruyère, Olivier ULg; Nicolet, Delphine ULg; Compère, Stéphanie et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 363-364

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See detailBornage: questions d'actualité et frais
Salvé, Arianne ULg

in Salvé, Arianne (Ed.) Chronique de droit à l'usage des juges de paix et de police (2012)

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See detailLong-term (3 years) reproducibility for the radiological assessment of knee osteoarthritis
DEROISY, Rita ULg; Bruyère, Olivier ULg; Gensburger, Deborah et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 219-220

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See detailInscriptions arabes d’Éthiopie
Bauden, Frédéric ULg

in Annales islamologiques (2012), 45(2011), 285-306

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See detailIncreasing the Detection Limit of the Parkinson Disorder through a Specific Surface Chemistry Applied onto Inner Surface of the Titration Well
Mille, Caroline; Debarnot; Zorzi, Willy ULg et al

in Journal of Functional Biomaterials (2012), 2

The main objective of this paper was to illustrate the enhancement of the sensitivity of ELISA titration for neurodegenerative proteins by reducing nonspecific adsorptions that could lead to false ... [more ▼]

The main objective of this paper was to illustrate the enhancement of the sensitivity of ELISA titration for neurodegenerative proteins by reducing nonspecific adsorptions that could lead to false positives. This goal was obtained thanks to the association of plasma and wet chemistries applied to the inner surface of the titration well. The polypropylene surface was plasma-activated and then, dip-coated with different amphiphilic molecules. These molecules have more or less long hydrocarbon chains and may be charged. The modified surfaces were characterized in terms of hydrophilic—phobic character, surface chemical groups and topography. Finally, the coated wells were tested during the ELISA titration of the specific antibody capture of the α-synuclein protein. The highest sensitivity is obtained with polar (Θ = 35°), negatively charged and smooth inner surface. [less ▲]

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