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See detailFive years of denosumab exposure in women with postmenopausal osteoporosis: Results from the first two years of the FREEDOM extension.
Papapoulos, S.; Chapurlat, R.; Libanati, C. et al

in Journal of Bone and Mineral Research (2012), 27(3), 694-701

The 3-year FREEDOM trial assessed the efficacy and safety of 60 mg denosumab every 6 months for treatment of postmenopausal women with osteoporosis. Participants who completed FREEDOM were eligible to ... [more ▼]

The 3-year FREEDOM trial assessed the efficacy and safety of 60 mg denosumab every 6 months for treatment of postmenopausal women with osteoporosis. Participants who completed FREEDOM were eligible to enter an extension to continue the evaluation of denosumab efficacy and safety for up to 10 years. For the extension results presented here, women from the FREEDOM denosumab group had 2 more years of denosumab treatment (long-term group) and those from the FREEDOM placebo group had 2 years of denosumab exposure (cross-over group). We report results for bone turnover markers (BTMs), bone mineral density (BMD), fractures rates, and safety. A total of 4550 women enrolled in the extension (2343 long-term; 2207 cross-over). Reductions in BTMs were maintained (long-term group) or occurred rapidly (cross-over group) following denosumab administration. In the long-term group, lumbar spine and total hip BMD increased further, resulting in 5-year gains of 13.7% and 7.0%, respectively. In the cross-over group, BMD increased at the lumbar spine (7.7%) and total hip (4.0%) during the 2-year denosumab treatment. Yearly fracture incidences for both groups were below rates observed in the FREEDOM placebo group and below rates projected for a "virtual untreated twin" cohort. Adverse events did not increase with long-term denosumab administration. Two adverse events in the cross-over group were adjudicated as consistent with osteonecrosis of the jaw (ONJ). Five-year denosumab treatment of women with postmenopausal osteoporosis maintained BTM reduction and increased BMD, and was associated with low fracture rates and a favorable risk/benefit profile. (c) 2011 American Society for Bone and Mineral Research. [less ▲]

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See detailSituation épidémiologique du virus de l’hépatite E chez le sanglier (Sus scrofa) en Belgique
Thiry, Damien ULg; Mauroy, Axel ULg; Brochier, Bernard et al

Poster (2012, March)

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See detailEffect of physicochemical characteristics of cellulosic substrates on enzymatic hydrolysis by means of a multi-stage process for cellobiose production
Vanderghem, Caroline ULg; Jacquet, Nicolas ULg; Danthine, Sabine ULg et al

in Applied Biochemistry and Biotechnology (2012), 166(6), 1423-1432

The effect of two types of cellulose, microcrystalline cellulose and paper pulp, on enzymatic hydrolysis for cellobiose production was investigated. The particle size, the relative crystallinity index and ... [more ▼]

The effect of two types of cellulose, microcrystalline cellulose and paper pulp, on enzymatic hydrolysis for cellobiose production was investigated. The particle size, the relative crystallinity index and the water retention value were determined for both celluloses. A previously studied multistage hydrolysis process that proved to enhance the cellobiose production was studied with both types of celluloses. The cellobiose yield exhibited a significant improvement (120% for the microcrystalline cellulose and 75% for the paper pulp) with the multistage hydrolysis process compared to continuous hydrolysis. The conversion of cellulose to cellobiose was greater for the microcrystalline cellulose than for the paper pulp. Even with high crystallinity, microcrystalline cellulose achieved the highest cellobiose yield probably due to its highest specific surface area accessible to enzymes and quantity of adsorbed protein. [less ▲]

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See detailModellierung des Trennverhaltens wässriger Systeme in Packungskolonnen basierend auf tomographischen
Janzen, Anna; Steube, Julia; Aferka, Saïd ULg et al

Conference (2012, March)

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See detailTreatment of a severe distal forelimb wound presenting with extensive laceration and distal interphalangeal joint luxation in a donkey
Brogniez, L; Launois,T; Perrin R et al

in Pferdeheilkunde (2012), 28(2), 160-166

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See detailLes "Litterae annuae" de la Compagnie de Jésus entre compte rendu factuel et construction identitaire : l’exemple de Bruxelles
Delfosse, Annick ULg

in Rousseaux, Xavier (Ed.) Quatre siècles de présence jésuite à Bruxelles (2012, March)

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See detailNewsletter n° 5 - DACEFI 2
Meunier, Quentin; Moumbogou, Carl; Angwé, A. et al

E-print/Working paper (2012)

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See detailRisk assessment of Belgian adults for furan contamination through the food chain
Scholl, Georges ULg; Humblet, Marie-France ULg; Scippo, Marie-Louise ULg et al

in Food Additives & Contaminants (2012), 29(3), 345-353

Risk assessment is an interdisciplinary process used to quantify the risk linked to a hazard. In the present paper it is applied to quantify the risk linked to furan ingestion through the food chain for ... [more ▼]

Risk assessment is an interdisciplinary process used to quantify the risk linked to a hazard. In the present paper it is applied to quantify the risk linked to furan ingestion through the food chain for the Belgian adult population. Two approaches, deterministic and probabilistic, were carried out in parallel. The deterministic method relied on a case study, whereas the probabilistic approach involved statistical distributions of contamination and consumption data to calculate a statistical distribution of the daily intake. First, the deterministic method revealed a low estimated daily intake (EDI) for the average population (380 ng*(kgbw*day)–1) and a huge contribution of coffee consumption to the EDI (55%). Increasing or decreasing the daily coffee consumption by one cup can affect the EDI by about 22%. Afterwards, the probabilistic approach showed that the average population has a low EDI (494 ng*(kgbw*day) 1), and that high contamination levels were only registered in a small proportion of the population. Finally, a comparison of the RfDchronic oral showed that less than 10% of the Belgian population had an EDI above the reference dose proposed by the USEPA; the majority of the population had an EDI 20% below the reference dose. The margin of exposure (MoE) approach indicated that the level of risk related to furan intake through ingestion is low, with a MoE>10,000 for more than 10% of the population and no result < 100. [less ▲]

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See detailMore Than a Phrase on a Food Label. The Health Claims as a Topological Space
Hendrickx, Kim ULg

Conference (2012, February 29)

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See detailFirst occurrence of the lungfish Sagenodus (Dipnoi, Sarcopterygii) from the Carboniferous Lagerstätte of Montceau-les-Mines, France
Olive, Sébastien ULg; Clément, Gaël; Pouillon, Jean-Marc

in Journal of Vertebrate Paleontology (2012), 32(2), 285-295

New material of the dipnoan genus Sagenodus is described from the Carboniferous Lagerstätte of Montceau-les-Mines, Massif Central, France. This is the first occurrence of this lungfish in France, thus ... [more ▼]

New material of the dipnoan genus Sagenodus is described from the Carboniferous Lagerstätte of Montceau-les-Mines, Massif Central, France. This is the first occurrence of this lungfish in France, thus enlarging its worldwide distribution; and the first occurrence of a lungfish in Montceau-les-Mines, thus increasing the vertebrate taxa list of this Lagerstätte. This material is Stephanian B in age, the previously established geological range of this Euramerican genus. Remains consist of skull, lower jaw, operculum, and shoulder girdle elements closely set together with several ribs. This material, here considered as belonging to a single disarticulated specimen, shows strong affinities with the material of Sagenodus sp. from Germany and appears significantly different from all other known species of Sagenodus by the shape and ridge pattern of the upper tooth plate. However, this new material can only be attributed to Sagenodus sp. due to its incompleteness. In the literature, Montceau-les-Mines is either interpreted as a freshwater environment or as a coastal marine to marine-influenced environment. As Sagenodus is a euryhaline genus; its presence in this locality does not bring arguments to one or the other assumption. The strong affinities, existing between the material from France and Germany, indicate that there were solid hydrographic links between both basins during the Stephanian B–Upper Rotliegend period. [less ▲]

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See detailAvoiding the elephant: the net and nearly zero energy building target in Belgium
Attia, Shady ULg; Mlecnik, Erwin

in World Sustainable Energy Days (2012, February 29)

The recast of the European Performance of Buildings Directive (EPBD) requires all new buildings to be “nearly zero energy’ buildings (nZEB) by 2020, including existing buildings undergoing major ... [more ▼]

The recast of the European Performance of Buildings Directive (EPBD) requires all new buildings to be “nearly zero energy’ buildings (nZEB) by 2020, including existing buildings undergoing major renovations. Belgium was even first to set a definition for a ‘net zero energy house’ (NZEB) in 2009. The revised Energy Performance in Buildings Directive calls governments to meet the nearly zero energy targets by 2020. Governments must adopt and publish regulations and procedures for the other requirements mainly the cost optimal calculation by July 2012. There are many elements of the recast Directive that pertain to new buildings. Unfortunately, the recast does not set targets for improving existing buildings and non-legislative measures will be needed to address how to achieve a greater share of renovation. Therefore, this paper aims to identify the share of the newly constructed buildings by 2020 in Belgium. The objective is to put the nearly zero energy targets in a wider perspective in relation to the existing building stock. The paper investigates some future scenarios for the national buildings stock growth rate, coupled with demographic growth by 2050. The study’s final results indicate that newly constructed building will be less than 7% by 2020 and less than 15% by 2050 in Belgium. Thus by not addressing the potential for energy renovations in the building sector the EPBD is avoiding the elephant. [less ▲]

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See detailComparaison entre l'huile de colza pure et le gasoil EN590
Lumaye, François ULg

Scientific conference (2012, February 29)

The experimental farm of GxABT-Université de Liège has a Deutz-Fahr M650 "Natural Power" tractor which is factory designed for rape oil. Indeed it's equipped with two fuel tanks: one for the EN590 gasoil ... [more ▼]

The experimental farm of GxABT-Université de Liège has a Deutz-Fahr M650 "Natural Power" tractor which is factory designed for rape oil. Indeed it's equipped with two fuel tanks: one for the EN590 gasoil and another for rape oil. A fuel consumption test show that rape oil running increase fuel consupmtion for more or less one liter per hour. [less ▲]

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See detailAnthropisation des paysages: Structure spatiale, impact écologique, entropie
Vranken, Isabelle ULg; Bogaert, Jan ULg; Visser, Marjolein

Poster (2012, February 29)

Structural and thermodynamic applications of entropy related to spatial heterogeneity under growing anthropogenic pressure have been examined. 16 zones from classified LANDSAT TM scenes presenting ... [more ▼]

Structural and thermodynamic applications of entropy related to spatial heterogeneity under growing anthropogenic pressure have been examined. 16 zones from classified LANDSAT TM scenes presenting different anthropogenic effect intensities have been used. Anthropogenic effects, compositional and configurational entropy have been measured. The scatter plot shows bell curves with maximal entropy at intermediate anthropogenic effects. Distinction of natural and anthropogenic classes shows opposed tendencies according to class and compositional/configurational type. These results have been interpreted as spatial transformation processes, energy production and release, and linked to the habitat heterogeneity and intermediate disturbance hypotheses. [less ▲]

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See detail4. La fumure azotée
Vancutsem, Françoise ULg; Seutin, Benoit ULg; Destain, Jean-Pierre ULg et al

in Livre Blanc - Céréales - Gembloux (2012, February 29)

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See detail5. Les régulateurs de croissance
Seutin, Benoit ULg; Vancutsem, Françoise ULg; Monfort, Bruno et al

in Livre Blanc - Céréales - Gembloux (2012, February 29)

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See detail10. Perspectives - Dynamique des populations de trois adventices des céréales en vue de la mise au point de méthodes intégrées de leur contrôle
Jaunard, Delphine ULg; Henriet, François; Monty, Arnaud ULg et al

in Livre Blanc - Céréales - Gembloux (2012, February 29)

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See detailPrinciples for nearly zero energy building in Belgium
Attia, Shady ULg; Mlecnik, Erwin

in World Sustainable Energy Days (2012, February 29)

The recast of the European Performance of Buildings Directive (EPBD) requires all new buildings to be “nearly zero energy’ buildings (nZEB) by 2020, including existing buildings undergoing major ... [more ▼]

The recast of the European Performance of Buildings Directive (EPBD) requires all new buildings to be “nearly zero energy’ buildings (nZEB) by 2020, including existing buildings undergoing major renovations. Belgium was first to set a definition for a ‘net zero energy house’ (NZEB) in 2009. Every year the definition is revised for consistency with shortcomings and emerging issues. However, to reach the nZEB objective many questions are raised in the Belgian context. Many uncertainties exist among local governments and municipalities to achieve that objective. Therefore, the paper presents a review on the current Belgian definition and its market status in comparison with the international context. The paper builds on existing experience with the implementation of the EPB calculation method and the Passive House initiative. The aim of the paper is to review current definition discussions and pave the way to a more consistent definition. Finally, four principles are suggested to reach the nZEB objectives in Belgium. [less ▲]

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