References of "2012"
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See detailDelayed puberty in a girl due to an inactivating mutation of the LH receptor
FUDVOYE, Julie ULg; PARENT, Anne-Simone ULg; Bourguignon, Jean-Pierre ULg

Poster (2012, March)

We report the case of a 46 XY patient with a disorder of sex differentiation (DSD) caused by an inactivating mutation of the LH receptor. Mutations of genes involved in hypothalamic-pituitary-gonadal ... [more ▼]

We report the case of a 46 XY patient with a disorder of sex differentiation (DSD) caused by an inactivating mutation of the LH receptor. Mutations of genes involved in hypothalamic-pituitary-gonadal function are rare but they provide an experience of nature for understanding the physiology and the pathophysiology of gonadotropins actions. There arise from correlation between the phenotypes and genotypes in those unique conditions. Management of this particular patient with no LH activity involves oestrogen replacement therapy to induce breast development together with a gonadectomy due to the risk of gonadoblastoma in streak gonads. [less ▲]

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See detailCost-effectiveness of bazedoxifene compared with raloxifene in the treatment of postmenopausal osteoporotic women
Hiligsmann, Mickaël ULg; Ben Sedrine, Wafa ULg; Bruyère, Olivier ULg et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 312-313

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See detailAN INNOVATIVE APPROACH TO SELECT THE PREDICTION MODEL IN THE DEVELOPMENT OF NIR SPECTROSCOPIC METHODS
Ziemons, Eric ULg; Mantanus, Jérôme ULg; Rozet, Eric ULg et al

Poster (2012, March)

Taking into account its non-invasive, non-destructive character and fast data acquisition, near infrared spectroscopy is more and more integrated in production processes to acquire analytical results ... [more ▼]

Taking into account its non-invasive, non-destructive character and fast data acquisition, near infrared spectroscopy is more and more integrated in production processes to acquire analytical results. Implementation of a NIR quantitative method is performed using an iterative heuristic approach that will ultimately build a model allowing the prediction of the concentration of the analyte of interest. In this context, the aim of the present study was to develop an innovative approach based on statistical tolerance intervals and the desirability index FMI (Fitting Model Index) to select the most appropriate prediction model from a list of candidate models instead of using conventional criteria such as R², RMSEC, RMSECV and RMSEP [1-2] without objective decision rules. This new approach is illustrated on different steps of a real pharmaceutical manufacturing process: water and Active Pharmaceutical Ingredient (API) determinations in pharmaceutical pellets. Variability sources such as production campaigns, batches, days and operators were introduced in the calibration and validation sets. Partial Least Square (PLS) regression on the calibration sets was performed to build prediction models of which the ability to quantify accurately was tested with the validation sets. Regarding the product specifications, the acceptance limits were set at 20% and 5%, for the moisture and API determination, respectively.As can be seen from Figure 1 and 2, this innovative approach based on the desirability index FMI of the accuracy profile enabled to build and select the most appropriate prediction model in full accordance with its very final goal, to quantify as accurately as possible the analytes of interest. [1] Hubert Ph. et al., J. Pharm. Biomed. Anal., 36, 2007, 579-586. [2] Rozet E. et al., Ana. Chim. Acta, 591, 2007, 239-247. [less ▲]

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See detailRadiological and clinical profil of osteoarthritic patients undergoing of total joint replacement
Neuprez, Audrey ULg; François, Garance ULg; Bruyère, Olivier ULg et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 129-130

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See detailAssessment of joint space narrowing in knee osteoarthritis has good long-term intercentre reproducibility when read in pairs with a semi-automated device
Gensburger, Deborah; DEROISY, Rita ULg; Arlot, Monique et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 247-248

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See detailClinical significance of Escherichia albertii
Ooka, Tadasuke; Seto, Kazuko; Linden, Annick ULg et al

in Emerging Infectious Diseases (2012), 18(3), 488-492

Discriminating Escherichia albertii from other Enterobacteriaceae is diffi cult. Systematic analyses showed that E. albertii represents a substantial portion of strains currently identifi ed as eae ... [more ▼]

Discriminating Escherichia albertii from other Enterobacteriaceae is diffi cult. Systematic analyses showed that E. albertii represents a substantial portion of strains currently identifi ed as eae-positive Escherichia coli and includes Shiga toxin 2f–producing strains. Because E. albertii possesses the eae gene, many strains might have been misidentifi ed as enterohemorrhagic or enteropathogenic E. coli. [less ▲]

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See detailAn economic evaluation of strontium ranelate for the treatment of male osteoporosis
Hiligsmann, Mickaël ULg; Ben Sedrine, Wafa ULg; Bruyère, Olivier ULg et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 305-306

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See detailSevere prevalent vertebral fractures predict subsequent vertebral and nonvertebral fractures: a 3-year prospective study
Bruyère, Olivier ULg; Roux, Christian; Nicolet, Delphine ULg et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 361-362

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See detailAutomata-Based Symbolic Representations of Polyhedra
Boigelot, Bernard ULg; Brusten, Julien ULg; Degbomont, Jean-François ULg

in Lecture Notes in Computer Science (2012, March), 7183

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See detailSome Applications of Mathematical Statistics in Management
Heuchenne, Cédric ULg

Scientific conference (2012, March)

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See detailEstablishment of parathyroid hormone (PTH) reference on 10 different assay kits: impact of the recruitment of the population
CAVALIER, Etienne ULg; SOUBERBIELLE, Jean-Claude

in Osteoporosis International (2012, March), 23(Supplement 2), 360

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See detailDifferential expression of Vegfr-2 and its soluble form in preeclampsia.
Munaut, Carine ULg; LORQUET, Sophie ULg; Pequeux, Christel ULg et al

in PLoS ONE (2012), 7(3), 33475

Background: Several studies have suggested that the main features of preeclampsia (PE) are consequences of endothelial dysfunction related to excess circulating anti-angiogenic factors, most notably ... [more ▼]

Background: Several studies have suggested that the main features of preeclampsia (PE) are consequences of endothelial dysfunction related to excess circulating anti-angiogenic factors, most notably, soluble sVEGFR-1 (also known as sFlt-1) and soluble endoglin (sEng), as well as to decreased PlGF. Recently, soluble VEGF type 2 receptor (sVEGFR-2) has emerged as a crucial regulator of lymphangiogenesis. To date, however, there is a paucity of information on the changes of VEGFR-2 that occur during the clinical onset of PE. Therefore, the aim of our study was to characterize the plasma levels of VEGFR-2 in PE patients and to perform VEGFR-2 immunolocalization in placenta. METHODOLOGY/PRINCIPAL FINDINGS: By ELISA, we observed that the VEGFR-2 plasma levels were reduced during PE compared with normal gestational age matched pregnancies, whereas the VEGFR-1 and Eng plasma levels were increased. The dramatic drop in the VEGFR-1 levels shortly after delivery confirmed its placental origin. In contrast, the plasma levels of Eng and VEGFR-2 decreased only moderately during the early postpartum period. An RT-PCR analysis showed that the relative levels of VEGFR-1, sVEGFR-1 and Eng mRNA were increased in the placentas of women with severe PE. The relative levels of VEGFR-2 mRNA as well as expressing cells, were similar in both groups. We also made the novel finding that a recently described alternatively spliced VEGFR-2 mRNA variant was present at lower relative levels in the preeclamptic placentas. CONCLUSIONS/SIGNIFICANCE: Our results indicate that the plasma levels of anti-angiogenic factors, particularly VEGFR-1 and VEGFR-2, behave in different ways after delivery. The rapid decrease in plasma VEGFR-1 levels appears to be a consequence of the delivery of the placenta. The persistent circulating levels of VEGFR-2 suggest a maternal endothelial origin of this peptide. The decreased VEGFR-2 plasma levels in preeclamptic women may serve as a marker of endothelial dysfunction. [less ▲]

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See detailDe la pédagogie au théâtre documentaire. Entretien avec Françoise Bloch
Delhalle, Nancy ULg

in Alternatives Théâtrales (2012), (112),

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See detailDifference between total and intact assays for N-terminal propeptide of type I procollagen in renal impaired patients
CAVALIER, Etienne ULg; CARLISI, Ignazia ULg; ROUSSELLE, Olivier ULg et al

in Osteoporosis International (2012, March), 23(Supplement 2), 339

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See detailL’Inventaire Systémique de Qualité de vie pour Adolescents (ISQV-A) : qualités psychométriques et application clinique
Etienne, Anne-Marie ULg; Missotten, Pierre ULg; Dupuis, Gilles

in Revue Francophone de Clinique Comportementale et Cognitive (2012), XVII(1), 44-56

Purpose: The objective was to determine the psychometric properties and the clinical application of a new Quality of Life self-assessment questionnaire suitable for adolescents 13 to 18 years old: the ... [more ▼]

Purpose: The objective was to determine the psychometric properties and the clinical application of a new Quality of Life self-assessment questionnaire suitable for adolescents 13 to 18 years old: the “Inventaire Systémique de Qualité de vie pour Adolescents” (ISQV-A). Methods: This was a cross-sectional validation study. 171 French adolescents have completed the ISQV-A. Other tools were used: the State-Trait Anxiety Inventory for Children (STAIC), the Children’s Depression Inventory (CDI). Results: The internal consistency of the four indices of the ISQV-A (state, goal, rank and gap) is satisfactory. All scores have their own specificity. The data show the convergent validity, test-retest fidelity and applicability of the ISQV-A. Conclusions: The adequacy of this new tool seems evident to highlight the adolescent’s quality of life. We will also discuss its clinical relevance into a cognitive behavioural approach. [less ▲]

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See detailThe birth of the Belgian Network for Science, Technology and Society (BSTS Network)
Delvenne, Pierre ULg; Thoreau, François ULg

in EASST Review (2012), 31(1), 9-12

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See detailIndirect comparison of bazedoxifene vs. oral bisphosphonates for the prevention of nonvertebral fractures in high-risk postmenopausal osteoporosis population
Ellis, A; Jansen, J; Luo, X et al

in Osteoporosis International (2012, March), 23(S2), 64-65

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See detailMrs Gandhi's Final Term and the Remaking of the Congress (I)'s Social Base
Maiorano, Diego ULg

in India Review (2012), 11(1),

This article examines the impact that national economic policies adopted during Indira Gandhi's final term in office (1980–84) had on four “national” social groups, namely the big industrialists, the ... [more ▼]

This article examines the impact that national economic policies adopted during Indira Gandhi's final term in office (1980–84) had on four “national” social groups, namely the big industrialists, the middle class, the rich peasantry, and the poor. The study argues that the Congress (I) chose the former two as its major allies, while the rich peasantry and the poor were relegated to a secondary position. In the process, the focus of India's strategy of development shifted from the agrarian to the industrial sector, and from the rural to the urban world. [less ▲]

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