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See detailA mixed solid-shell element for the analysis of laminated composites
Rah, Kamran; Paepegem, Wim; Habraken, Anne ULg et al

in International Journal for numerical methods in engineering (2012), 89(7), 805-828

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See detailG protein-coupled receptors, an unexploited animal toxin targets: Exploration of green mamba venom for novel drug candidates active against adrenoceptors
Maïga, Arhamatoulaye; Mourier, Gilles; Quinton, Loïc ULg et al

in Toxicon (2012), 59

At a time when pharmaceutical companies are having trouble finding new low MW drugs and when biologics are becoming more common, animal venoms could constitute an underexploited source of novel drug ... [more ▼]

At a time when pharmaceutical companies are having trouble finding new low MW drugs and when biologics are becoming more common, animal venoms could constitute an underexploited source of novel drug candidates. We looked for identifying novel animal toxins active against G protein-coupled receptors (GPCR), the most frequently exploited class of treatment targets, with the aim to develop novel research tools and drug candidates. Screening of green mamba (Dendroaspis angusticeps) venom against adrenoceptors identified two novel venom peptides. r-Da1a shown an affinity of 0.35 nM for the a1a-AR while r-Da1b displayed affinities between 14 and 73 nM for the three a2-ARs. These two venom peptides have sequences similar to those of muscarinic toxins and belong to the three-finger-fold protein family. a1a-AR is the primary target for the treatment of prostate hypertrophy. In vitro and in vivo tests demonstrated that r-Da1a reduced prostatic muscle tone as efficiently as tamsulosin (an antagonist presently used), but with fewer cardiovascular side effects. a2-ARs are the prototype of GPCRs not currently used as treatment targets due to a lack of specific ligands. Blockage of these receptors increases intestinal motility, which may be compromised by abdominal surgery and reduces orthosteric hypotension. In vitro and in vivo tests demonstrated that r-Da1b antagonizes a2-ARs in smooth muscles and increased heart rate and blood catecholamine concentrations. These results highlight possible exploitation of r-Da1a and r-Da1b in important pathologies. [less ▲]

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See detailApproche par compétences et réduction des inégalités d'apprentissage entre élèves
Beckers, Jacqueline ULg; Crinon, Jacques; Simons, Germain ULg

Book published by De Boeck (2012)

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See detailEcological review of black-grass (Alopecurus myosuroides Huds.) propagation abilities in relationship with herbicide resistance
Maréchal, Pierre-Yves ULg; Henriet, François; Vancutsem, Françoise ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2012), 16(1),

Alopecurus myosuroides Huds. (vulpin des champs) a toujours été une préoccupation majeure pour les céréaliculteurs et le développement de la résistance aux herbicides n’améliore pas la situation. Cet ... [more ▼]

Alopecurus myosuroides Huds. (vulpin des champs) a toujours été une préoccupation majeure pour les céréaliculteurs et le développement de la résistance aux herbicides n’améliore pas la situation. Cet article de synthèse résume les différents critères impliqués dans les modèles de dispersion d’individus de vulpin des champs au sein d’un champ ou d’une population sensible. Pour ce faire, le cycle complet du vulpin est décrit de la semence à la semence. Depuis le développement végétatif précoce jusqu’à la chute de la graine, chaque étape est décrite en prenant en compte comment la résistance aux herbicides peut influencer ou exercer un impact différent par rapport à des plantes sensibles. [less ▲]

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See detailDexamethasone pretreatment provides antiinflammatory and myocardial protection in neonatal arterial switch operation.
Heying, Ruth; Wehage, Edith; SCHUMACHER, Katharina ULg et al

in Annals of Thoracic Surgery (2012), 93(3), 869-76

BACKGROUND: This prospective double-blinded randomized study tested the hypothesis that preoperative treatment with dexamethasone would attenuate inflammatory priming of the myocardium, reduce the ... [more ▼]

BACKGROUND: This prospective double-blinded randomized study tested the hypothesis that preoperative treatment with dexamethasone would attenuate inflammatory priming of the myocardium, reduce the systemic inflammatory reaction upon cardiac operation, and provide organ protection in neonates. METHODS: Twenty neonates (age, 8 to 21 days) with transposition of the great arteries scheduled for arterial switch operation were included. Nine received dexamethasone (1 mg/kg body weight) 4 hours before cardiopulmonary bypass, and 11 received natrium chloride. We studied intramyocardial messenger RNA expression of interleukin (IL)-6, IL-8, IL-1beta, and tumor necrosis factor-alpha (TNF-alpha), as well as IL-10 and expression of TNF-alpha on protein level in right atrial tissue taken before institution of CPB. We measured plasma levels of IL-6, IL-10, lipopolysaccharide binding protein, and cardiac troponin T. Cytokine expression was related to postoperative outcome. RESULTS: Pretreatment with dexamethasone led to a significant decrease in myocardial expression of IL-6, IL-8, IL-1beta, and TNF-alpha messenger RNA and to a decrease in protein synthesis of TNF-alpha. Plasma concentrations of IL-6 were significantly lower and those of IL-10 significantly higher in pretreated patients. This was associated with lower cardiac troponin T values and lower dobutamine requirement. Levels of lipopolysaccharide binding protein were significantly higher postoperatively in pretreated neonates. CONCLUSIONS: Dexamethasone administration before arterial switch operation leads to a shift in the myocardial and systemic cytokine expression profile in neonates with transposition of the great arteries, with downregulation of proinflammatory and upregulation of antiinflammatory cytokines. Lower myocardial cell damage and lower catecholamine requirement suggest myocardial protection in treated patients. [less ▲]

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See detailcarnet de pédiatrie en Afrique: Les conséquences de la prématurité
Battisti, Oreste ULg

Learning material (2012)

cours de master complémentaire en pédiatrie.

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See detailFormer des enseignants à une approche par compétences efficace et équitable
Beckers, Jacqueline ULg; Campo, Anne ULg

in Beckers, Jacqueline; Crinon, Jacques; Simons, Germain (Eds.) Approche par compétences et réduction des inégalités d'apprentissage entre élèves (2012)

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See detailTi alloys processed by selective laser melting and by laser cladding: microstructures and mechanical properties
Mertens, Anne ULg; Contrepois, Quentin ULg; Dormal, Thierry ULg et al

in proceedings of 12th EUROPEAN CONFERENCE ON SPACECRAFT STRUCTURES, MATERIALS & ENVIRONMENTAL TESTING, Noordwijk 20-23 mars 2012 (2012, March)

Selective laser melting (SLM) and laser cladding were developed in the late 1990s as economic layer-by-layer near-net-shape processes allowing for the production – and also, in the case of laser cladding ... [more ▼]

Selective laser melting (SLM) and laser cladding were developed in the late 1990s as economic layer-by-layer near-net-shape processes allowing for the production – and also, in the case of laser cladding, the restoration - of complex parts. Both techniques involve the melting of a metallic powder with a laser. In the case of SLM, the metallic powder is deposited layer by layer and then molten locally according to the desired shape, whereas in laser cladding the metallic powder is projected onto a substrate through a tube coaxial with the laser. In both processes, the metallic melt pools then cool down and solidify very rapidly, thus producing strongly out of equilibrium microstructures that might exhibit high internal stresses. In the present work, efforts have been made to enhance the flexibility of the laser cladding process: a second laser with a maximum power of 300W was installed beside the original laser (with a higher maximum power of 2000W), thus allowing for the processing of parts with thinner walls and/or coatings. Moreover, flexibility was also improved in relation with the geometry of the parts by use of a 5-axes displacement control. Samples of alloy Ti-6Al-4V, that is widely used in the aeronautic industry due to its high specific strength, have been processed both by SLM and by laser cladding. The resulting microstructures have been characterised in details by optical microscopy, SEM and EBSD so as to allow for a better understanding of the solidification process and of the subsequent phase transformations taking place upon cooling for both techniques. The influence of processing parameters such as the orientation of the deposition of the successive powder layers on the mechanical properties was also investigated by means of uniaxial tensile testing performed on samples with different deposition orientations in regard to the direction of mechanical solicitation. Moreover, some of the samples for mechanical testing had undergone an annealing treatment at 640°C for 4 hours to relieve internal stresses, in order to assess more precisely the effect of those stresses on the tensile properties. [less ▲]

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See detailFrom direct to inverse analysis in flexible multibody dynamics
Bruls, Olivier ULg

Conference (2012, March)

Today, state-of-the-art simulation packages in flexible multibody dynamics allow the high-fidelity analysis of industrial mechanisms and machines in many application fields including robotics, automotive ... [more ▼]

Today, state-of-the-art simulation packages in flexible multibody dynamics allow the high-fidelity analysis of industrial mechanisms and machines in many application fields including robotics, automotive systems, aeronautics, deployable structures or wind turbines. The dynamic response of a given system can thus be evaluated in the time-domain for given load cases and given initial values. However, in many practical cases, the engineer does not have a precise knowledge of the mechanical design, the loading conditions and the initial state. This situation occurs for example in structural optimization, optimal control, experimental identification and health monitoring problems. The complexity of simulation codes and the computational cost of high-fidelity models are still important obstacles for the development of efficient resolution methods for these inverse problems. A current challenge is thus to elaborate simplified and more efficient modelling strategies in flexible multibody dynamics in order to enable the development of inverse analysis methods. The talk is divided into three parts. The first part provides an overview of available simulation techniques for flexible mechanisms with a particular emphasis on finite element-based approaches and time integration methods. Some illustrations are presented in the fields of deployable structures, vehicle dynamics and wind turbines. In the second part, optimization problems in flexible multibody dynamics are addressed and solved using gradient-based methods. Efficient methods for sensitivity analysis are discussed and special problems are treated such as the structural optimization of mechanical components or the numerical solution of inverse dynamics problems. The third part discusses a recently-developed Lie group approach which allows the formulation of the equations of motion of a multibody system in a parameterization-free setting. Based on this general formalism, which is characterized by an increased modularity and a reduced complexity, a large variety of Lie group solvers are foreseen not only for time integration but also for model reduction, sensitivity analysis and optimization. [less ▲]

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See detailNeurophysiological indices of top-down attentional processing in minimally conscious patients : an ERP study.
Schnakers, C.; Lovstad, M.; Boly, M. et al

Conference (2012, March)

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See detailFair Trade Organizations and Social Enterprise. Social Innovation through Hybrid Organization Models
Huybrechts, Benjamin ULg

Book published by Routledge (2012)

For several decades, Fair Trade Social Enterprises (FTSEs) have set up partnerships with producer groups in the South and distributed the latter’s products through different types of channels in the North ... [more ▼]

For several decades, Fair Trade Social Enterprises (FTSEs) have set up partnerships with producer groups in the South and distributed the latter’s products through different types of channels in the North. However, while pioneers in the early years were relatively homogeneous (nonprofit organizations relying on voluntary work and selling through “worldshops”), organizational diversity has tremendously increased in recent times, including other types of legal forms, architectures, and governance models (volunteer-based, manager-based, multi-stakeholder, etc.). As a result, different categories of FTSEs now coexist in the sector with diverse missions and strategies. Since Fair Trade (FT) is a hybrid concept, entailing economic, social and political dimensions, the diversity of organizational models might reflect or enable different ways of articulating these dimensions. In other words, different organizational models might be suited for different ways of conceiving and practicing FT. Such an articulation through specific forms has been suggested by previous concepts that can be related to FT, such as cooperatives, the social economy, the solidarity economy, and, more recently, social enterprise. The latter is particularly useful as an umbrella concept that embraces the diverse types of FTSEs and accounts for their use of market mechanisms to pursue social innovation. This research first aims to explore and to structure FTSEs’ organizational diversity. For that purpose, the managers of 57 FTSEs were interviewed in four European regions: Belgium, France (Rhône-Alpes), the United Kingdom (England) and Italy (Rome). Based on the combinations of different elements of the organizational form, five categories emerge: individual FTSEs; entrepreneurial, business-form FTSEs; volunteer-based FTSEs; multi-stakeholder cooperative FTSEs; and group structures. Although certain FTSEs share features corresponding to several models, these categories seem adequate in the sense are relatively homogeneous and distinct from each other. The second question examines the factors or forces that lead FTSEs to adopt particular and diverse organizational forms. Using sociological and economic “new institutional” approaches, this book explores the influence of a number of factors on the organizational form: age, size, region, goals, activities, resources, and leaders’ profiles. From an economic standpoint, organizational diversity may be explained by the fact that FTSEs do not all produce the same types of goods when practicing FT. Thus, FTSEs will adopt the organizational form that minimizes their transaction costs in the production of particular goods. From a sociological standpoint, the analysis suggests that weak and sometimes conflicting institutional pressures explain organizational diversity. Indeed, uniformity is limited (within certain generations of FTSEs or in particular regions), although there is a dominant trend toward a stronger business orientation in the models. The third question examines how organizational actors within FTSEs experience and foster hybridity at the field level, thereby contributing to organizational diversification. Looking at six cases of FTSEs covering the different types of models, the strategic role of FTSEs is examined, as “institutional entrepreneurs” capable of influencing the environment in a way that legitimizes their own organizational model and secures their access to crucial resources. This strategic analysis allows for a more dynamic view of organizational models as “institutional bricolage”. Finally, the book ends with a number of recommendations for FT entrepreneurs on the strengths and the weaknesses of each organizational model. [less ▲]

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See detailLes techniques d'instrumentation en prothèse fixe
KOENIG, Vinciane ULg

Scientific conference (2012, March)

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See detailL'influence de la gouvernance familiale sur la transmission de la PME familiale au Sénégal : une modélisation contingente
Van Caillie, Didier ULg; Mbili Onana,

in COMREFAS - Consortium pour le Management de la Recherche Fondamentale en Afrique au Sud du Sahara (Ed.) Actes du 1er Congrès International en Sciences de Gestion du COMREFAS (2012, March)

In Senegal, family businesses are present in all industries and represent a significant force. Most of family entrepreneurs are between 40 and 50 years old, which show that they will soon face the ... [more ▼]

In Senegal, family businesses are present in all industries and represent a significant force. Most of family entrepreneurs are between 40 and 50 years old, which show that they will soon face the challenge of transmission. To face this challenge and thus to ensure their continuity, it is necessary to ensure the cohesion of family ties, particularly through the family governance. So, our contribution aims, in a contingent perspective and based on a large survey of the existing literature, to a better appraisal of family businesses in Senegal through a better understanding of their family governance practices first, and by understanding the role of family governance on their global performance in order to identify key success factors for a successful family transmission process in the context of Senegal. [less ▲]

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See detailHeisenberg-limited metrology without entanglement
Braun, Daniel; Martin, John ULg

Conference (2012, March)

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See detailFoodborne Outbreak by a Recombinant Norovirus GIIg/1 Strain in a University Hospital in Munich
Hoffmann, Dieter; Mauroy, Axel ULg; Foley, Brian et al

Poster (2012, March)

Detailed reference viewed: 55 (1 ULg)