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See detailEffect of physicochemical characteristics of cellulosic substrates on enzymatic hydrolysis by means of a multi-stage process for cellobiose production
Vanderghem, Caroline ULg; Jacquet, Nicolas ULg; Danthine, Sabine ULg et al

in Applied Biochemistry and Biotechnology (2012), 166(6), 1423-1432

The effect of two types of cellulose, microcrystalline cellulose and paper pulp, on enzymatic hydrolysis for cellobiose production was investigated. The particle size, the relative crystallinity index and ... [more ▼]

The effect of two types of cellulose, microcrystalline cellulose and paper pulp, on enzymatic hydrolysis for cellobiose production was investigated. The particle size, the relative crystallinity index and the water retention value were determined for both celluloses. A previously studied multistage hydrolysis process that proved to enhance the cellobiose production was studied with both types of celluloses. The cellobiose yield exhibited a significant improvement (120% for the microcrystalline cellulose and 75% for the paper pulp) with the multistage hydrolysis process compared to continuous hydrolysis. The conversion of cellulose to cellobiose was greater for the microcrystalline cellulose than for the paper pulp. Even with high crystallinity, microcrystalline cellulose achieved the highest cellobiose yield probably due to its highest specific surface area accessible to enzymes and quantity of adsorbed protein. [less ▲]

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See detailUn pôle d'excellence wallon en santé articulaire.
Henrotin, Yves ULg

Article for general public (2012)

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See detailAnalyse des mécanismes de transfert de fluides lors d'essais de séchage convectif sur un limon
Gerard, Pierre ULg; Léonard, Angélique ULg; Charlier, Robert ULg et al

in Skoczykas, Frédéric; Davy, Catherine; Agostini, Franck (Eds.) et al Actes du colloque Transfert 2012 - Propriétés de transfert des géomatériaux (2012, March)

Des essais de séchage convectif ont été réalisés sur des échantillons de limon en vue de quantifier la cinétique de perte de masse. Ces essais ont été analysés sous l’hypothèse de l’existence d’une couche ... [more ▼]

Des essais de séchage convectif ont été réalisés sur des échantillons de limon en vue de quantifier la cinétique de perte de masse. Ces essais ont été analysés sous l’hypothèse de l’existence d’une couche limite en paroi de l’échantillon, dans laquelle des transferts de masse et de chaleur ont lieu. L’article met en avant l’intérêt de modélisations thermo-hydrauliques pour comprendre les transferts de fluides au sein de l’échantillon. Une analyse précise des résultats numériques permet de déterminer si les transferts internes sont constitués principalement d’advection d’eau liquide jusqu’à la paroi suivi par de l’évaporation, ou plutôt de l’avancée d’un front d’évaporation au sein de l’échantillon suivi par de la diffusion de la vapeur jusqu’à la paroi. [less ▲]

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See detailUne approche modulaire d’évaluation de la qualité de vie en oncologie pédiatrique : les versions française et portugaise de l’Inventaire Systémique de Qualité de Vie pour Enfants (ISQV-E©)
Missotten, Pierre ULg; Fonseca, Marta; Dupuis, Gilles et al

in Revue Francophone de Clinique Comportementale et Cognitive (2012), XVII(1), 15-33

This study approaches the question of quality of life measure in paediatric oncology. The main aim is to compare the quality of life level of children (8-12 years) undergoing (T) and off (HT) oncological ... [more ▼]

This study approaches the question of quality of life measure in paediatric oncology. The main aim is to compare the quality of life level of children (8-12 years) undergoing (T) and off (HT) oncological treatments by using the French and the Portuguese modular versions of the Child Quality of Life Systemic Inventory (QLSI-C©). The Portuguese sample consists of 26 children T and 14 HT while the Belgian sample includes 20 children T and 35 HT. Results demonstrate statistically significant differences between the T and HT groups, particularly for the French version of the QLSI-C©. They also give evidence of the influence of some clinical and sociodemographic variables on the global quality of life score, mainly for the Portuguese version of the QLSI-C©. In conclusion, findings demonstrate the clinical interest of French and Portuguese versions of the QLSI-C© and their capacity to distinguish children undergoing oncological treatments from children off these treatments. [less ▲]

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See detailNote de recherche n°33. La Politique de la ville
Harou, Raphaëlle; Lejeune, Zoé ULg

Report (2012)

Cette note de recherche relative à la politique de la ville en Wallonie a été réalisée dans le cadre du diagnostic territorial confié à la CPDT pour l’actualisation du Schéma de développement de l’espace ... [more ▼]

Cette note de recherche relative à la politique de la ville en Wallonie a été réalisée dans le cadre du diagnostic territorial confié à la CPDT pour l’actualisation du Schéma de développement de l’espace régional wallon en 2010-2011. Le présent document propose de revenir sur les différents aspects de la politique à destination des villes en Wallonie. Même si la Région ne dispose pas encore d’une politique spécifiquement dédiée à ses villes, elle a développé une série d’instruments qui participent à la redynamisation des zones urbaines. De plus, une réflexion a été lancée en 2011 afin de définir les grandes orientations à donner à une future politique de la ville en Wallonie. [less ▲]

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See detailFormer des enseignants à une approche par compétences efficace et équitable
Beckers, Jacqueline ULg; Campo, Anne ULg

in Beckers, Jacqueline; Crinon, Jacques; Simons, Germain (Eds.) Approche par compétences et réduction des inégalités d'apprentissage entre élèves (2012)

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See detailLeptogenesis in the presence of exact flavor symmetries
Aristizabal Sierra, Diego ULg; Bazzocchi, Federica

in Journal of High Energy Physics [=JHEP] (2012)

In models with flavor symmetries in the leptonic sector leptogenesis can take place in a very different way compared to the standard leptogenesis scenario. We study the generation of a B−L asymmetry in ... [more ▼]

In models with flavor symmetries in the leptonic sector leptogenesis can take place in a very different way compared to the standard leptogenesis scenario. We study the generation of a B−L asymmetry in these kind of models in the flavor symmetric phase pointing out that successful leptogenesis requires (i) the right-handed neutrinos to lie in different irreducible representations of the flavor group; (ii) the flavons to be lighter at least that one of the right-handed neutrino representations. When these conditions are satisfied leptogenesis proceeds due to new contributions to the CP violating asymmetry and — depending on the specific model — in several stages. We demonstrate the validity of these arguments by studying in detail the generation of the B − L asymmetry in a scenario of a concrete A 4 flavor model realization. [less ▲]

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See detailGiddens et la modernité radicale
Jacquemain, Marc ULg

in Politique : Revue de Débats (2012), 74(mars-avril),

L'article examine brièvement comment la théorie de la modernité réflexive de Giddens, appliquée au domaine de l'intime et de la construction du soi, conduit à sa construction politique de la "troisième ... [more ▼]

L'article examine brièvement comment la théorie de la modernité réflexive de Giddens, appliquée au domaine de l'intime et de la construction du soi, conduit à sa construction politique de la "troisième voie". Le texte défend que, y compris pour les critiques "de gauche" de Giddens, son analyse de la modernité est utile, parce qu'elle décrit - en creux - les limites de la portée émancipatrice de la réflexivité. [less ▲]

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See detailL'identité européenne et la mondialisation - commentateur
Hermans, Michel ULg

Conference (2012, March)

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See detailDifferential expression of Vegfr-2 and its soluble form in preeclampsia.
Munaut, Carine ULg; LORQUET, Sophie ULg; Pequeux, Christel ULg et al

in PLoS ONE (2012), 7(3), 33475

Background: Several studies have suggested that the main features of preeclampsia (PE) are consequences of endothelial dysfunction related to excess circulating anti-angiogenic factors, most notably ... [more ▼]

Background: Several studies have suggested that the main features of preeclampsia (PE) are consequences of endothelial dysfunction related to excess circulating anti-angiogenic factors, most notably, soluble sVEGFR-1 (also known as sFlt-1) and soluble endoglin (sEng), as well as to decreased PlGF. Recently, soluble VEGF type 2 receptor (sVEGFR-2) has emerged as a crucial regulator of lymphangiogenesis. To date, however, there is a paucity of information on the changes of VEGFR-2 that occur during the clinical onset of PE. Therefore, the aim of our study was to characterize the plasma levels of VEGFR-2 in PE patients and to perform VEGFR-2 immunolocalization in placenta. METHODOLOGY/PRINCIPAL FINDINGS: By ELISA, we observed that the VEGFR-2 plasma levels were reduced during PE compared with normal gestational age matched pregnancies, whereas the VEGFR-1 and Eng plasma levels were increased. The dramatic drop in the VEGFR-1 levels shortly after delivery confirmed its placental origin. In contrast, the plasma levels of Eng and VEGFR-2 decreased only moderately during the early postpartum period. An RT-PCR analysis showed that the relative levels of VEGFR-1, sVEGFR-1 and Eng mRNA were increased in the placentas of women with severe PE. The relative levels of VEGFR-2 mRNA as well as expressing cells, were similar in both groups. We also made the novel finding that a recently described alternatively spliced VEGFR-2 mRNA variant was present at lower relative levels in the preeclamptic placentas. CONCLUSIONS/SIGNIFICANCE: Our results indicate that the plasma levels of anti-angiogenic factors, particularly VEGFR-1 and VEGFR-2, behave in different ways after delivery. The rapid decrease in plasma VEGFR-1 levels appears to be a consequence of the delivery of the placenta. The persistent circulating levels of VEGFR-2 suggest a maternal endothelial origin of this peptide. The decreased VEGFR-2 plasma levels in preeclamptic women may serve as a marker of endothelial dysfunction. [less ▲]

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See detailLes secrets de l'astrolabe - suite
Nazé, Yaël ULg

Article for general public (2012)

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See detailL'influence de la gouvernance familiale sur la transmission de la PME familiale au Sénégal : une modélisation contingente
Van Caillie, Didier ULg; Mbili Onana,

in COMREFAS - Consortium pour le Management de la Recherche Fondamentale en Afrique au Sud du Sahara (Ed.) Actes du 1er Congrès International en Sciences de Gestion du COMREFAS (2012, March)

In Senegal, family businesses are present in all industries and represent a significant force. Most of family entrepreneurs are between 40 and 50 years old, which show that they will soon face the ... [more ▼]

In Senegal, family businesses are present in all industries and represent a significant force. Most of family entrepreneurs are between 40 and 50 years old, which show that they will soon face the challenge of transmission. To face this challenge and thus to ensure their continuity, it is necessary to ensure the cohesion of family ties, particularly through the family governance. So, our contribution aims, in a contingent perspective and based on a large survey of the existing literature, to a better appraisal of family businesses in Senegal through a better understanding of their family governance practices first, and by understanding the role of family governance on their global performance in order to identify key success factors for a successful family transmission process in the context of Senegal. [less ▲]

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See detailIncidence of Abcd1 level on the induction of cell death and organelle dysfunctions triggered by very long chain fatty acids and TNF-alpha on oligodendrocytes and astrocytes
Baarine, Mauhamad; Ragot, Kevin; Athias, Anne et al

in NeuroToxicology (2012), 33(2)

X-linked adrenoleukodystrophy (X-ALD) is characterized by ABCD1 deficiency. This disease is associated with elevated concentrations of very long chain fatty acids (C24:0 and C26:0) in the plasma and ... [more ▼]

X-linked adrenoleukodystrophy (X-ALD) is characterized by ABCD1 deficiency. This disease is associated with elevated concentrations of very long chain fatty acids (C24:0 and C26:0) in the plasma and tissues of patients. Under its severe form, brain demyelination and inflammation are observed. Therefore, we determined the effects of C24:0 and C26:0 on glial cells:oligodendrocytes, which synthesize myelin, and astrocytes, which participate in immune response. So, 158N murine oligodendrocytes, rat C6 glioma cells, rat primary cultures of neuronal–glial cells, and of oligodendrocytes were treated for various periods of time in the absence or presence of C24:0 and C26:0 used at plasmatic concentrations found in X-ALD patients (1–5 μM) and higher (10, 20, 40 μM). To evaluate the importance of extrinsic and intrinsic factors, the part taken by TNF-α and reduced Abcd1 level was studied. Whatever the cells considered, no effects on cell growth and/or viability were detected at 1–5 μM, more or less pronounced effects were identified at 10 μM, and an induction of cell death with increased permeability to propidium iodide and loss of transmembrane mitochondrial potential was observed at 20–40 μM. On 158N, cell death was characterized by (i) an increased superoxide anion production at the mitochondrial level; (ii) the presence of vacuoles of different sizes and shapes; a destabilization of lysosomal membrane and a cytoplasmic redistribution of lysosomes; (iii) a modulation of Abcd3/PMP70 and Acox-1 protein expression, and a decrease in catalase activity at the peroxisomal level. When TNF-α was combined with C24:0 or C26:0 and used on 158N cells, C6 cells, and on 158N cells after siRNA mediated knockdown of Abcd1, no or slight potentiation was revealed. Thus, on the different cell models used, an induction of cell death with marked cellular dysfunctions at the mitochondrial, lysosomal, and peroxisomal levels were found with C24:0 and C26:0 at 20 μM and higher. However, in our experimental conditions, plasmatic concentrations of these fatty acids were unable to induce cell death, and organelle dysfunctions on oligodendrocytes and astrocytes, and additional intrinsic and environmental factors, such as reduced Abcd1 level and/or TNF-α, were ineffective to potentiate their side effects. [less ▲]

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See detailLe religieux et le politique en Afrique subsaharienne
Melice, Anne ULg

Scientific conference (2012, March)

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See detailImproved Domain Decomposition Method for the Wave Equation in Harmonic Regime
Geuzaine, Christophe ULg; Antoine, X.; Boubendir, Y. et al

in Proceedings of the 6th Advanced Computational Electromagnetics workshop (ACE 2012) (2012, March)

Detailed reference viewed: 31 (2 ULg)