References of "2012"
     in
Bookmark and Share    
Full Text
See detailJames McAuley
Delrez, Marc ULg

Article for general public (2012)

Detailed reference viewed: 13 (6 ULg)
Peer Reviewed
See detailDoes pupil constriction under blue and green monochromatic light exposure change with age?
Daneault, V; Vandewalle, Gilles ULg; Hébert, M et al

Poster (2012, February)

Detailed reference viewed: 20 (0 ULg)
Full Text
Peer Reviewed
See detailDifferential proteomic analysis of a human breast tumor and its matched bone metastasis identifies cell membrane and extracellular proteins associated with bone metastasis
Dumont, Bruno ULg; Castronovo, Vincenzo ULg; Peulen, Olivier ULg et al

in Journal of Proteome Research (2012)

The classical fate of metastasizing breast cancer cells is to seed and form secondary colonies in bones. The molecules closely associated with these processes are predominantly present at the cell surface ... [more ▼]

The classical fate of metastasizing breast cancer cells is to seed and form secondary colonies in bones. The molecules closely associated with these processes are predominantly present at the cell surface and in the extracellular space, establishing the first contacts with the target tissue. In this study, we had the rare opportunity to analyze a bone metastatic lesion and its corresponding breast primary tumor obtained simultaneously from the same patient. Using mass spectrometry, we undertook a proteomic study on cell surface and extracellular protein-enriched material. We provide a repertoire of significantly modulated proteins, some with yet unknown roles in the bone metastatic process as well as proteins notably involved in cancer cell invasiveness and in bone metabolism. The comparison of these clinical data with those previously obtained using a human osteotropic breast cancer cell line highlighted an overlapping group of proteins. Certain differentially expressed proteins are validated in the present study using immunohistochemistry on a retrospective collection of breast tumors and matched bone metastases. Our exclusive set of selected proteins supports the set-up of further investigations on both clinical samples and experimental bone metastasis models that will help to reveal the finely coordinated expression of proteins that favor the development of metastases in the bone microenvironment. [less ▲]

Detailed reference viewed: 101 (17 ULg)
See detailMicroorganisms from aphid honeydew attract natural enemies and tending ants
Verheggen, François ULg; Leroy, Pascal; Fischer, Christophe ULg et al

Conference (2012, February)

Aphids are some of the most serious pests of cultivated crops worldwide, causing major yield and economic losses. Previous works have demonstrated ants and natural enemies (including ladybeetles and ... [more ▼]

Aphids are some of the most serious pests of cultivated crops worldwide, causing major yield and economic losses. Previous works have demonstrated ants and natural enemies (including ladybeetles and hoverflies) to be able to use aphid volatile chemicals to locate aphid colonies. Here, we report the first isolation of a bacterium from the pea aphid Acyrthosiphon pisum honeydew, Staphylococcus sciuri, which produces kairomones used by the aphidophagous hoverfly Episyrphus balteatus and the Asian Ladybeetle Harmonia axyridis during their search for prey colonies. Some specific semiochemicals produced by S. sciuri were identified as attractants and ovipositional stimulants. Similarly, we have shown scouts of the aphid tending ant species, Lasius niger, to orientate their foraging behaviour toward an Aphis fabae infested plant and we have demonstrated that the odours released by this aphid honeydew were attractive for ant scouts. Again, bacteria were involved in the production of these honeydew semiochemicals. Interestingly, ant scouts were also able to discriminate honeydew odour from A. fabae (usually attended by L. niger) and A. pisum (unattendedby L. niger). Comparison of the volatile and bacteria composition of both aphid species honeydew were attended. [less ▲]

Detailed reference viewed: 38 (7 ULg)
See detailUne introduction à la nouvelle vague. Parcours croisés de François Truffaut et Jean-Luc Godard
Tomasovic, Dick ULg

Conference given outside the academic context (2012)

Detailed reference viewed: 33 (2 ULg)
Full Text
See detailDaljit Nagra: Sourires de tigre et dents brunes
Munos, Delphine ULg

Article for general public (2012)

Detailed reference viewed: 17 (3 ULg)
Full Text
Peer Reviewed
See detailQUALITY BY DESIGN COMPLIANT METHOD VALIDATION
Rozet, Eric ULg; Boulanger, B.; Hubert, Philippe ULg

Poster (2012, February)

Analytical method validation is a mandatory step to evaluate the ability of developed methods to provide accurate results for their routine application in order to trust the critical decisions that will ... [more ▼]

Analytical method validation is a mandatory step to evaluate the ability of developed methods to provide accurate results for their routine application in order to trust the critical decisions that will be made with them. Even if several guidelines exist to help perform analytical method validations (ICH Q2R1 [1], USP <1225> [2], …) there is still the need to clarify the meaning and interpretation of analytical method validation criteria and methodology. Indeed, actually method validation is mostly realised as the traditional check list implementation of e.g. the ICH Q2R1 or USP <1225> method validation requirements. However, within the trend of Quality by Design [3], there is the need to switch from this traditional vision to an analytical method validation really adding value and providing a high level of assurance of analytical methods results reliability. Yet, different interpretations can be made of the validation guidelines as well as for the definitions of the validation criteria. This will lead to diverse experimental designs implemented to try fulfilling these criteria. Finally, different decision methodologies can also be interpreted from these guidelines. Therefore, the risk that a validated analytical method may be unfit for its future purpose will depend on a personal interpretation of these guidelines. The objective of this presentation is thus to show that analytical method validation should be planned and performed by first starting with the end in mind: what is the objective of the analytical methods under study? In such a way analytical method validation is coherent with the actual Quality by Design regulatory expectations. The risk of having validated an analytical method unfit for its purpose is strongly reduced as well as the risk of generating Out of Specification (OOS) results due to an unfit method. References [1] International Conference on Harmonisation (ICH) of Technical Requirements for registration of Pharmaceuticals for Human Use, Topic Q2 (R1): Validation of Analytical Procedures: Text and Methodology, Geneva, 2005. [2] USP 33 NF 28 S1, U.S. Pharmacopeia, 2007. USP–NF General Chapter <1225>. [3] International Conference on Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use, Topic Q8(R2): Pharmaceutical development, Geneva, 2009. [less ▲]

Detailed reference viewed: 125 (5 ULg)
Full Text
Peer Reviewed
See detailEddy Currents and Corner Singularities
Buret, François; Dauge, Monique; Dular, Patrick ULg et al

in IEEE Transactions on Magnetics (2012), 48(2), 679-682

Eddy current problems are addressed in a bidimensional setting where the conducting medium is non-magnetic and has a corner singularity. For any fixed parameter linked to the skin depth for a plane ... [more ▼]

Eddy current problems are addressed in a bidimensional setting where the conducting medium is non-magnetic and has a corner singularity. For any fixed parameter linked to the skin depth for a plane interface, we show that the flux density is bounded near the corner unlike the perfect conducting case. Then as goes to zero, the first two terms of a multiscale expansion of the magnetic potential are introduced to tackle the magneto-harmonic problem. The heuristics of the method are given and numerical computations illustrate the obtained accuracy. [less ▲]

Detailed reference viewed: 26 (5 ULg)
Full Text
See detailDossier Texas - Alan Govenar
Sacré, Robert ULg

Article for general public (2012)

Detailed reference viewed: 9 (1 ULg)
Full Text
See detailRapport 2 FIRST Spin Off IMONIC
Goffin, Dorothée ULg

Report (2012)

Rapport du projet FIRST spin-off IMONIC financé par le SPW (Production de mélanges à valeur santé contenant des isomaltooligosaccharides et de l’acide gluconique prébiotiques et répondant au cahier des ... [more ▼]

Rapport du projet FIRST spin-off IMONIC financé par le SPW (Production de mélanges à valeur santé contenant des isomaltooligosaccharides et de l’acide gluconique prébiotiques et répondant au cahier des charges de l’agriculture biologique). [less ▲]

Detailed reference viewed: 34 (8 ULg)
Full Text
Peer Reviewed
See detailRutherford backscattering analysis of porous thin TiO2 films
Mayer, Matej; von Toussaint, Udo; Dewalque, Jennifer ULg et al

in Nuclear Instruments & Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms (2012), 273

The additional energy spread due to sample porosity was implemented in the SIMNRA simulation code, version 6.60 and higher. Deviations of the path length and energy loss distributions from the ones ... [more ▼]

The additional energy spread due to sample porosity was implemented in the SIMNRA simulation code, version 6.60 and higher. Deviations of the path length and energy loss distributions from the ones expected from a Poisson distribution of the number of traversed pores are taken into account. These deviations are due to the interaction of pores at higher pore concentrations by overlap or blocking. The skewnesses of the energy distributions are approximated by two-piece normal distributions with identical first three moments. Propagation of porosity-induced energy spread in thick layers is taken into account. Calculated results are compared to experimental data obtained with thin TiO2 mesoporous films measured by Rutherford backscattering (RBS),transmission electron microscopy (TEM), and atmospheric poroellipsometry. [less ▲]

Detailed reference viewed: 76 (27 ULg)
Full Text
Peer Reviewed
See detailOn different types of adjustment usable to calculate the parameters of the stream power law
Demoulin, Alain ULg; Beckers, Arnaud ULg; Bovy, Benoît ULg

in Geomorphology (2012), 138(1), 203-208

Model parameterization through adjustment to field data is a crucial step in the modeling and the understanding of the drainage network response to tectonic or climatic perturbations. Using as a test case ... [more ▼]

Model parameterization through adjustment to field data is a crucial step in the modeling and the understanding of the drainage network response to tectonic or climatic perturbations. Using as a test case a data set of 18 knickpoints that materialize the migration of a 0.7-Ma-old erosion wave in the Ourthe catchment of northern Ardennes (western Europe), we explore the impact of various data fitting on the calibration of the stream power model of river incision, from which a simple knickpoint celerity equation is derived. Our results show that statistical least squares adjustments (or misfit functions) based either on the streamwise distances between observed and modeled knickpoint positions at time t or on differences between observed and modeled time at the actual knickpoint locations yield significantly different values for the m and K parameters of the model. As there is no physical reason to prefer one of these approaches, an intermediate least-rectangles adjustment might at first glance appear as the best compromise. However, the statistics of the analysis of 200 sets of synthetic knickpoints generated in the Ourthe catchment indicate that the timebased adjustment is the most capable of getting close to the true parameter values. Moreover, this fitting method leads in all cases to an m value lower than that obtained from the classical distance adjustment (for example, 0.75 against 0.86 for the real case of the Ourthe catchment), corresponding to an increase in the non-linear character of the dependence of knickpoint celerity on discharge [less ▲]

Detailed reference viewed: 79 (13 ULg)
Full Text
Peer Reviewed
See detailOn the human pose recovery based on a single view
Pierard, Sébastien ULg; Van Droogenbroeck, Marc ULg

in International conference on pattern recognition applications and methods (ICPRAM) (2012, February)

Estimating the pose of the observed person is crucial for a large variety of applications including home entertainment, man-machine interaction, video surveillance, etc. Often, only a single side view is ... [more ▼]

Estimating the pose of the observed person is crucial for a large variety of applications including home entertainment, man-machine interaction, video surveillance, etc. Often, only a single side view is available, but authors claim that it is possible to derive the pose despite that humans evolve in a 3D environment. In addition, to decrease the sensitivity to color and texture, it is preferable to rely only on the silhouette to recover the pose. Under these conditions, we show that there is an intrinsic limitation: at least two poses correspond to the observed silhouette. We discuss this intrinsic limitation in details in this short paper. To our knowledge, this issue has been overlooked by authors in the past. We observe that this limitation has an impact on the way previous reported results should be interpreted, and it has clearly to be taken into account for designing new methods. [less ▲]

Detailed reference viewed: 104 (13 ULg)
Full Text
Peer Reviewed
See detailBio-ORACLE: a global environmental dataset for marine species distribution modelling
Tyberghein, Lennert; Verbruggen, Heroen; Klaas, Pauly et al

in Global Ecology & Biogeography (2012), 21(2), 272-281

Detailed reference viewed: 31 (1 ULg)
Full Text
See detailLa relation professionnelle : l'expérience de la logopédie
Maillart, Christelle ULg

Scientific conference (2012, January 31)

Detailed reference viewed: 19 (4 ULg)