A brown dwarf orbiting an M-dwarf: MOA 2009-BLG-411L; ; et al in Astronomy and Astrophysics (2012), 547 Context. Caustic crossing is the clearest signature of binary lenses in microlensing. In the present context, this signature is diluted by the large source star but a detailed analysis has allowed the ... [more ▼] Context. Caustic crossing is the clearest signature of binary lenses in microlensing. In the present context, this signature is diluted by the large source star but a detailed analysis has allowed the companion signal to be extracted. <BR /> Aims: MOA 2009-BLG-411 was detected on August 5, 2009 by the MOA-Collaboration. Alerted as a high-magnification event, it was sensitive to planets. Suspected anomalies in the light curve were not confirmed by a real-time model, but further analysis revealed small deviations from a single lens extended source fit. <BR /> Methods: Thanks to observations by all the collaborations, this event was well monitored. We first decided to characterize the source star properties by using a more refined method than the classical one: we measure the interstellar absorption along the line of sight in five different passbands (VIJHK). Secondly, we model the lightcurve by using the standard technique: make (s,q,α) grids to look for local minima and refine the results by using a downhill method (Markov chain Monte Carlo). Finally, we use a Galactic model to estimate the physical properties of the lens components. <BR /> Results: We find that the source star is a giant G star with radius 9 R[SUB]&sun;[/SUB]. The grid search gives two local minima, which correspond to the theoretical degeneracy s ≡ s[SUP]-1[/SUP]. We find that the lens is composed of a brown dwarf secondary of mass M[SUB]S[/SUB] = 0.05 M[SUB]&sun;[/SUB] orbiting a primary M-star of mass M[SUB]P[/SUB] = 0.18 M[SUB]&sun;[/SUB]. We also reveal a new mass-ratio degeneracy for the central caustics of close binaries. <BR /> Conclusions: As far as we are aware, this is the first detection using the microlensing technique of a binary system in our Galaxy composed of an M-star and a brown dwarf. Appendix is available in electronic form at <A href="http://www.aanda.org">http://www.aanda.org</A> [less ▲] Detailed reference viewed: 10 (0 ULg) The BNP and the FN: Between islamophobia and the defense of democratic valuesJamin, Jérôme ![]() Conference (2012) Detailed reference viewed: 7 (0 ULg) The HMG-Box Transcription Factor Sox4b Is Required for Pituitary Expression of gata2a and Specification of Thyrotrope and Gonadotrope Cells in Zebrafish.Quiroz O'Donova, Yobhana ; Lopez, Marie-Josée ; et alin Molecular Endocrinology (2012), 26(6), 1014-1027 The pituitary is a complex gland comprising different cell types each secreting specific hormones. The extensive network of signaling molecules and transcription factors required for determination and ... [more ▼] The pituitary is a complex gland comprising different cell types each secreting specific hormones. The extensive network of signaling molecules and transcription factors required for determination and terminal differentiation of specific cell types is still not fully understood. The SRY-like HMG-box (SOX) transcription factor Sox4 plays important roles in many developmental processes and has two homologs in zebrafish, Sox4a and Sox4b. We show that the sox4b gene is expressed in the pituitary anlagen starting at 24 h after fertilization (hpf) and later in the entire head region including the pituitary. At 48 hpf, sox4b mRNA colocalizes with that for TSH (tshbeta), glycoprotein subunit alpha (gsualpha), and the Zn finger transcription factor Gata2a. Loss of Sox4b function, using morpholino knockdown or expression of a dominant-negative Sox4 mutant, leads to a drastic decrease in tshbeta and gsualpha expression and reduced levels of gh, whereas other anterior pituitary gland markers including prl, slbeta, pomc, and lim3 are not affected. Sox4b is also required for expression of gata2a in the pituitary. Knockdown of gata2a leads to decreased tshbeta and gsualpha expression at 48 hpf, similar to sox4b morphants. Injection of gata2a mRNA into sox4b morphants rescued tshbeta and gsualpha expression in thyrotrope cells. Finally, sox4b or gata2a knockdown causes a significant decrease of gonadotropin expression (lhbeta and fshbeta) at 4 d after fertilization. In summary, our results indicate that Sox4b is expressed in zebrafish during pituitary development and plays a crucial role in the differentiation of thyrotrope and gonadotrope cells through induction of gata2a expression in the developing pituitary. [less ▲] Detailed reference viewed: 20 (8 ULg) Investigation of liquid flow pattern inside a structured packing using X-ray tomographyAferka, Saïd ; ; et alin Proceedings of the 6th International Symposium on Process Tomography, Cape Town, South Africa (2012) This work focuses on the analysis of X-ray tomographic images of liquid flow distribution within a 1 m high packed column of 10 cm diameter, filled with four Mellapak Plus 752Y elements. Tomographic ... [more ▼] This work focuses on the analysis of X-ray tomographic images of liquid flow distribution within a 1 m high packed column of 10 cm diameter, filled with four Mellapak Plus 752Y elements. Tomographic measurements are performed at various column heights for different liquid flowrates. Water and aqueous glycerine solutions are successively used as working liquids in order to quantify the influence of liquid viscosity on the spatial distribution of hydrodynamic quantities such as liquid holdup and gas-liquid interfacial area. Logically, both liquid holdup and gas-liquid interfacial area increase with liquid flow rate. An increase of liquid viscosity has also a positive impact on liquid holdup and on gas-liquid interfacial area. In all cases, the measured quantities are not constant along the bed height, leading to fluctuating axial profiles. Depending on the liquid viscosity and flowrate, different liquid flow patterns (films, rivulets, flooded channels) are observed in the irrigated cross section images. A method based on morphological techniques is proposed to quantify the fraction of liquid flow which belongs to each flow pattern. [less ▲] Detailed reference viewed: 43 (5 ULg) Solutal Marangoni instability of binary mixtures evaporating into air: an analytical model describing highly unstable casesMachrafi, Hatim ; ; et alin Book of abstracts of the Seventh International Symposium on TWO-PHASE SYSTEMS FOR GROUND AND SPACE APPLICATIONS (2012) Detailed reference viewed: 3 (1 ULg) Flux-based Risk Assessement of the impact of Contaminants on Water resources and ECOsystemsJamin, Pierre ; ; et alReport (2012) Detailed reference viewed: 22 (3 ULg) Fibulin 3 peptides Fib3-1 and Fib3-2 are potential biomarkers of osteoarthritis.Henrotin, Yves ; ; Mazzucchelli, Gabriel et alin Arthritis and Rheumatism (2012), 64(7), 2260-7 OBJECTIVE: This study was undertaken to identify new biomarkers of osteoarthritis (OA) by proteomics analysis and to develop specific immunoassays to detect and quantify them. METHODS: Proteomics analysis ... [more ▼] OBJECTIVE: This study was undertaken to identify new biomarkers of osteoarthritis (OA) by proteomics analysis and to develop specific immunoassays to detect and quantify them. METHODS: Proteomics analysis was performed in urine samples from 10 women (mean+/-SD age 76.0+/-5.0 years) undergoing knee replacement surgery due to severe OA and 5 healthy women (mean+/-SD age 25.6+/-2.6 years). Protein content was analyzed by 2-dimensional differential gel electrophoresis. Protein spots that exhibited an OA:control abundance ratio of >/=1.5 were identified by mass spectrometry. Specific enzyme-linked immunosorbent assays were developed and validated in serum obtained from 236 healthy subjects ages 20-64 years and from 76 patients with severe radiologic knee OA (mean+/-SD age 68.8+/-11.9 years). Immunohistochemical analysis was performed on articular cartilage from tibial plateaus. RESULTS: Thirteen proteins within spots that were significantly modified between groups were identified. Two peptides of fibulin 3, named Fib3-1 and Fib3-2, were of particular interest. Two antisera directed against these peptides were used to develop immunoassays. Compared with age-matched healthy subjects, median levels of serum Fib3-1 and Fib3-2 were elevated in OA patients (54.6 pM versus 85.1 pM [P<0.0001] and 144.4 pM versus 191.4 pM [P<0.0001], respectively). Using area under the receiver operating characteristic curve analysis, we demonstrated that Fib3-1 and Fib3-2 levels discriminate between OA and normal populations. Immunostaining revealed the presence of Fib3-1 and Fib3-2 in chondrocytes and in the extracellular matrix of the superficial layer of the fibrillated cartilage. CONCLUSION: Our findings indicate that Fib3-1 and Fib3-2 are potential biochemical markers for the diagnosis of OA. [less ▲] Detailed reference viewed: 16 (4 ULg) Control of Allergen-Induced Inflammation and Hyperresponsiveness by the Metalloproteinase ADAMTS-12Paulissen, Geneviève ; ; Rocks, Natacha et alin Journal of Immunology (2012), 189 A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) constitute a family of endopeptidases related to matrix metalloproteinases. These proteinases have been largely implicated in tissue ... [more ▼] A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) constitute a family of endopeptidases related to matrix metalloproteinases. These proteinases have been largely implicated in tissue remodeling associated with pathological processes. Among them, ADAMTS12 was identified as an asthma-associated gene in a human genome screening program. However, its functional implication in asthma is not yet documented. The present study aims at investigating potential ADAMTS-12 functions in experimental models of allergic airways disease. Two different in vivo protocols of allergen-induced airways disease were applied to the recently generated Adamts12-deficient mice and corresponding wild-type mice. In this study, we provide evidence for a protective effect of ADAMTS-12 against bronchial inflammation and hyperresponsiveness. In the absence of Adamts12, challenge with different allergens (OVA and house dust mite) led to exacerbated eosinophilic inflammation in the bronchoalveolar lavage fluid and in lung tissue, along with airway dysfunction assessed by increased airway responsiveness following methacholine exposure. Furthermore, mast cell counts and ST2 receptor and IL-33 levels were higher in the lungs of allergen-challenged Adamts12-deficient mice. The present study provides, to our knowledge, the first experimental evidence for a contribution of ADAMTS-12 as a key mediator in airways disease, interfering with immunological processes leading to inflammation and airway hyperresponsiveness. [less ▲] Detailed reference viewed: 43 (18 ULg) Les troubles de la thermorégulation de l'enfant avec cas illustrés.Battisti, Oreste ![]() Book published by les éditions de l'Université de Liège (2012) Detailed reference viewed: 59 (3 ULg) L'esthétique de Husserl. Présentation d'une table rondeSteinmetz, Rudy ![]() Conference (2012) Detailed reference viewed: 34 (4 ULg) Decoding the folding of Burkholderia glumae lipase: folding intermediates en route to kinetic stability; ; Feller, Georges et alin PLoS ONE (2012), 7(5), 36999 Detailed reference viewed: 13 (4 ULg) A national cohort of HIV-infected patients in Belgium: design and main characteristics.; ; et al in Acta Clinica Belgica (2012), 67(5), 333-7 In Belgium, individual laboratory and treatment data of all HIV-infected patients seen in the 9 AIDS Reference Centres and 7 AIDS Reference Laboratories are collected prospectively since 2006. We present ... [more ▼] In Belgium, individual laboratory and treatment data of all HIV-infected patients seen in the 9 AIDS Reference Centres and 7 AIDS Reference Laboratories are collected prospectively since 2006. We present here an analysis of patients recorded in the cohort database between 1st of January 2006 and 31st of December 2008. During that period, 11982 patients were under medical follow-up in Belgium. Sixty-one percent of the patients were male and the median age was 39.8 at the time of first recorded viral load. Among the patients whose nationality or probable mode of transmission was recorded, nearly half (48.0%) were Belgian and 38.3% originated from Sub-Saharan Africa; heterosexual contacts were reported in the majority of cases (56.0%) followed by homosexual contacts (35.3%). A total of 145 deaths were reported. Around three quarters of the patients were on ART. The median CD4 cell count rose from 470 cells/mm3 in 2006 to 501 cells/mm3 in 2008. This cohort enabled us to obtain comprehensive information on the numbers and characteristics of HIV-infected patients currently being followed up in Belgium, and on trends in antiretroviral therapy and biological results. This will serve for planning purposes, evaluation of access to care and as a source of information for further studies. [less ▲] Detailed reference viewed: 25 (18 ULg) An investigation on thermal performance of a low cost apartment in hot humid climate of DanangNguyen, Anh Tuan ; Reiter, Sigrid ![]() in Energy and Buildings (2012), 47 Low cost apartment has recently become one of the essential state policies to deal with rapid urbanisation and population boom in Vietnam. Thermal performance of a low cost apartment in Danang was ... [more ▼] Low cost apartment has recently become one of the essential state policies to deal with rapid urbanisation and population boom in Vietnam. Thermal performance of a low cost apartment in Danang was examined using building simulation approach. The simulated results created by COMFIE were first calibrated by comparing them with measured data. The statistical indicators CV(RMSE) and NMBE as well as linear regression analysis were applied to assess the calibration. The calibrated model was then used to perform whole year simulations in which various ventilation and design strategies were applied. Thermal comfort potentials of these strategies were graphically defined by Brager’s adaptive comfort model from which the efficiency of each strategy was quantitatively determined. In the present paper, details of the calibration approach, assessment of simulated results and comparison of the findings were discussed. Results of these analyses revealed many notable findings which are in good agreement with those obtained from other publications. The limitation and recommendations for further study are also outlined. [less ▲] Detailed reference viewed: 51 (10 ULg) Appel au peuple/appel du public : décrire la réception comme une adresseServais, Christine ![]() in Questions de Communication (2012) Par rapport à d'autres productions culturelles ou scientifiques, la particularité des médias de masse est qu'ils font quelque chose au peuple en faisant quelque chose du peuple, c'est-à-dire en le ... [more ▼] Par rapport à d'autres productions culturelles ou scientifiques, la particularité des médias de masse est qu'ils font quelque chose au peuple en faisant quelque chose du peuple, c'est-à-dire en le représentant à lui-même. La construction mass-médiatique du "peuple" a donc une dimension pragmatique que les études de réception doivent intégrer. C'est à quoi s'attache cette communication, notamment à travers la notion d'adresse, issue du travail de J. Derrida, et celle de "partage du sensible" formalisée par Jacques Rancière. [less ▲] Detailed reference viewed: 78 (36 ULg) Brève comparaison entre le fonctionnement des établissements chargés de la gestion du temporel du culte et celui des ASBLHusson, Jean-François ; in Dossiers d'ASBL Actualités (Les) (2012), 13 Cet article compare sur 20 points (missions, organes, budget, compte, subsides, tutelle, marchés publics,...) les ASBL et les établissements chargés du temporel des cultes. L'attention porte ... [more ▼] Cet article compare sur 20 points (missions, organes, budget, compte, subsides, tutelle, marchés publics,...) les ASBL et les établissements chargés du temporel des cultes. L'attention porte principalement sur les fabriques d'église mais les établissements des autres cultes, ainsi que les établissements d'assistance morale laïque, sont également abordés. [less ▲] Detailed reference viewed: 11 (2 ULg) Les insertions lyriques dans le théâtre médiévalHenrard, Nadine ![]() in Grossel, Marie-Geneviève (Ed.) La chanson de trouvère — formes, registres, genres — (2012) Pour mettre en évidence certains passages des mystères et structurer leur texte, les fatistes ont eu recours à des variations métriques. Il s’agit souvent de rompre la succession des octosyllabes à rimes ... [more ▼] Pour mettre en évidence certains passages des mystères et structurer leur texte, les fatistes ont eu recours à des variations métriques. Il s’agit souvent de rompre la succession des octosyllabes à rimes plates par une diversification de l’agencement des rimes ou par l’utilisation d’autres types de vers. Mais les fatistes n’hésitent pas à couler les dialogues dans des structures beaucoup plus élaborées qui empruntent à des formes consacrées en poésie, comme celles du rondeau, ou plus sporadiquement, de la ballade. Il s’agira d’examiner comment ces morceaux lyriques s’insèrent dans le cours du drame, en s’interrogeant sur les lieux privilégiés où ils apparaissent, sur la manière dont les vers qui les composent se distribuent, et sur leur articulation éventuelle avec le paratexte didascalique (la rubrique permet-elle le repérage du morceau par une mention précise ? contient-elle des indications quant à une exécution musicale ? y a-t-il des verbes introducteurs spécifiques liés à ces énoncés ? ces passages entraînent-ils une mise en scène particulière ? etc). L'étude s'intéresse ainsi à la manière dont la lyrique est mise au service des effets dramatiques. Les exemples sont empruntés à des drames liturgiques bilingues, et des mystères en langue d’oïl et d'oc. [less ▲] Detailed reference viewed: 27 (1 ULg) Chapiter 10: Identification of mechanosensitive genes in chondrocytes and osteoblasts and their role in OA pathogenesisHenrotin, Yves ; Pesesse, Laurence ; Sanchez, Christelle ![]() in Kamklin, Andre; Kiseleva, Irina (Eds.) Mechanical stretch and cytokines (2012) Detailed reference viewed: 12 (2 ULg) Timing of Carotid Endarterectomy : a Comprehensive ReviewBRULS, Samuel ; VAN DAMME, Hendrik ; DEFRAIGNE, Jean ![]() in Acta Chirurgica Belgica (2012), 212 Detailed reference viewed: 94 (8 ULg) Impact of formic/acetic acid and ammonia pre-treatments on chemical structure and physico-chemical properties of Miscanthus x giganteus ligninsVanderghem, Caroline ; Richel, Aurore ; Jacquet, Nicolas et alin Polymer Degradation & Stability (2012), 96(10), 1761-1770 Miscanthus x giganteus was treated with formic acid/acetic acid/water (30/50/20 v/v) for 3 h at 107 C and 80° C, and soaking in aqueous ammonia (25% w/w) for 6 h at 60 C. The effects of these ... [more ▼] Miscanthus x giganteus was treated with formic acid/acetic acid/water (30/50/20 v/v) for 3 h at 107 C and 80° C, and soaking in aqueous ammonia (25% w/w) for 6 h at 60 C. The effects of these fractionation processes on chemical structure, physico-chemical properties and antioxidant activity of extracted lignins were investigated. Lignins were characterized by their purity, carbohydrate composition, thermal stability, molecular weight and by Fourier transform infrared (FTIR), 1H and quantitative 13C nuclear magnetic resonance (NMR), adiabatic broadband {13C-1H} 2D heteronuclear (multiplicity edited) single quantum coherence (g-HSQCAD). The radical scavenging activity towards 2,2-diphenyl-1-picrylhydrazyl (DPPH) was also investigated. Formic/acetic acid pretreatment performed in milder conditions (80° C for 3 h) gave a delignification percentage of 44.7% and soaking in aqueous ammonia 36.3%. Formic/acetic acid pretreatment performed in harsh conditions (107°C for 3 h) was more effective for extensive delignification (86.5%) and delivered the most pure lignin (80%). The three lignin fractions contained carbohydrate in different extent: 3% for the lignin obtained after the formic/acetic acid pretreatment performed at 107 C (FAL-107), 5.8% for the formic/acetic acid performed at 80°C (FAL-80) and 13.7% for the ammonia lignin (AL). The acid pretreatment in harsh conditions (FAL-107) resulted in cleavage of b-O-4' bonds and aromatic C-C. Repolymerisation was thought to originate from formation of new aromatic C-O linkages. Under milder conditions (FAL-80) less b-O-4' linkages were broken and repolymerisation took place to a lesser extent. Ammonia lignin was not degraded to a significant extent and resulted in the highest weight average 3140 g mol -1. Despite the fact of FAL-107 repolymerisation, significant phenolic hydroxyls remained free, explaining the greater antioxidant activity. [less ▲] Detailed reference viewed: 83 (62 ULg) |
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