References of "2012"
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See detailLa prothèse fixe minimalement invasive.
MAINJOT, Amélie ULg

Conference (2012, March)

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See detailRegulation of a-Synuclein Membrane Binding and Its Implications
Chen, Robert; Wislet, Sabine ULg; Mount, Howard et al

in Juliana Dushanova (Ed.) Mechanisms in Parkinson Disease models and treatment (2012)

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See detailLa lettre des Scipions adressée à la cité de Colophon (190-189a)
Famerie, Etienne ULg

Conference (2012, March)

Un riche dossier du Fonds Louis Robert conservé à l’Académie des Inscriptions et Belles-Lettres (copies, photographies, estampages, correspondance entre De Sanctis et Holleaux) éclaire l’histoire confuse ... [more ▼]

Un riche dossier du Fonds Louis Robert conservé à l’Académie des Inscriptions et Belles-Lettres (copies, photographies, estampages, correspondance entre De Sanctis et Holleaux) éclaire l’histoire confuse des éditions de cette lettre des Scipions (RDGE, 36). Le dossier permet aussi de donner une édition revue, qui n’est pas sans incidence sur le texte d’une autre lettre des deux frères (RDGE, 35). [less ▲]

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See detailRéduction des inégalités sociales de santé : quels défis éducatifs ? L'exemple du jeu
Absil, Gaëtan ULg; Vandoorne, Chantal ULg

in Education Santé (2012), (276), 8-12

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See detailCarte hydrogéologique de Wallonie, Louveigné-Spa, 49/3-4
Ruthy, Ingrid ULg; Dassargues, Alain ULg

Cartographic material (2012)

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See detailG protein-coupled receptors, an unexploited animal toxin targets: Exploration of green mamba venom for novel drug candidates active against adrenoceptors
Maïga, Arhamatoulaye; Mourier, Gilles; Quinton, Loïc ULg et al

in Toxicon (2012), 59

At a time when pharmaceutical companies are having trouble finding new low MW drugs and when biologics are becoming more common, animal venoms could constitute an underexploited source of novel drug ... [more ▼]

At a time when pharmaceutical companies are having trouble finding new low MW drugs and when biologics are becoming more common, animal venoms could constitute an underexploited source of novel drug candidates. We looked for identifying novel animal toxins active against G protein-coupled receptors (GPCR), the most frequently exploited class of treatment targets, with the aim to develop novel research tools and drug candidates. Screening of green mamba (Dendroaspis angusticeps) venom against adrenoceptors identified two novel venom peptides. r-Da1a shown an affinity of 0.35 nM for the a1a-AR while r-Da1b displayed affinities between 14 and 73 nM for the three a2-ARs. These two venom peptides have sequences similar to those of muscarinic toxins and belong to the three-finger-fold protein family. a1a-AR is the primary target for the treatment of prostate hypertrophy. In vitro and in vivo tests demonstrated that r-Da1a reduced prostatic muscle tone as efficiently as tamsulosin (an antagonist presently used), but with fewer cardiovascular side effects. a2-ARs are the prototype of GPCRs not currently used as treatment targets due to a lack of specific ligands. Blockage of these receptors increases intestinal motility, which may be compromised by abdominal surgery and reduces orthosteric hypotension. In vitro and in vivo tests demonstrated that r-Da1b antagonizes a2-ARs in smooth muscles and increased heart rate and blood catecholamine concentrations. These results highlight possible exploitation of r-Da1a and r-Da1b in important pathologies. [less ▲]

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See detailNonlinear Modal Analysis of the SmallSat Spacecraft
Renson, Ludovic ULg; Noël, Jean-Philippe ULg; Kerschen, Gaëtan ULg et al

in Proceedings of the European Conference on Spacecraft Structures, Materials & Environmental Testing (2012, March)

Non-linear elements are present in practically all spacecraft structures. When such non-linear effects are important linear modal analysis can no longer be applied. The development of a non-linear ... [more ▼]

Non-linear elements are present in practically all spacecraft structures. When such non-linear effects are important linear modal analysis can no longer be applied. The development of a non-linear analogue of linear modal analysis is therefore an important endeavor. The objective of this paper is to show that nonlinear normal modes (NNMs) represent a useful and practical tool in this context. A full-scale spacecraft structure is considered and is modeled using the finite element method. Its NNMs are computed using advanced numerical algorithms, and the resulting dynamics is then carefully analyzed. Nonlinear phenomena with no linear counterpart including nonlinear modal interactions are also highlighted. [less ▲]

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See detailStrontium ranelate uncouples bone formation from bone resorption in male osteoporotic patients
COLLETTE, Julien ULg; Reginster, Jean-Yves ULg

in Osteoporosis International (2012, March), 23(S2), 365-366

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See detailAMP-activated protein kinase controls liposaccharide-induced hyperpermeability
Castanares-Zapatero, Diego; Overtus, M; Communi, Didier et al

in Critical Care (2012, March), 16(suppl 1), 17

Organ dysfunction determines the severity of sepsis and is correlated to mortality. Endothelial increased permeability contributes to the development of organ failure. AMP-activated protein kinase (AMPK ... [more ▼]

Organ dysfunction determines the severity of sepsis and is correlated to mortality. Endothelial increased permeability contributes to the development of organ failure. AMP-activated protein kinase (AMPK) has been shown to modulate cytoskeleton and could mediate endothelial permeability. Our hypothesis is that AMPK controls sepsis-induced hyperpermeability in the heart and is involved in septic cardiomyopathy. Sepsis was induced by intraperitoneal injection of liposaccharide, 10 mg/kg (LPS). Alpha-1 AMPK knockout mice (α1KO) were compared with wild-type. Vascular permeability was characterized by Evans blue extravasation. Inflammatory cytokine mRNA expression was determined by qPCR analysis. Left ventricular mass was assessed by echocardiography. In addition, to emphasize the beneficial role of AMPK on heart vascular permeability, AMPK activator (acadesine) was administered to C57Bl6 mice before LPS injection. The ANOVA test with Bonferroni's post hoc test and the log-rank test were used. P < 0.05 was considered as significant. Increased cardiac vascular permeability was observed in the LPS group in comparison to untreated animals (2.5% vs. 16%; P < 0.05). The α1KO mice exhibited an increase vascular permeability after LPS injection in comparison to wild-type mice (41.5% vs. 16%; P < 0.05). α1KO animals had a significant mortality increase after LPS injection (70% vs. 10%; P < 0.05). LPS markedly induced the production of proinflammatory cytokines (TNFα, IL-1β, IL-6) that were significantly higher in the α1KO animals. More importantly, LPS treatment leads to an increased left ventricular mass in the α1KO mice within 24 hours, suggesting the onset of edema. Finally LPS-induced vascular hyperpermeability was greatly reduced after AMPK activation by acadesine (13.2% vs. 40%; P < 0.05). AMPK importantly regulates cardiac vascular permeability and could control the sepsis-induced cardiomyopathy. AMPK could represent a new pharmacological target of sepsis. [less ▲]

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See detailMise au point d’une méthode de traitement par micro-ondes des bois d’emballage destinés à l’exportation comme alternative aux mesures phytosanitaires actuellement appliquées (bromure de méthyle et traitement thermique).
Leyman, Michaël ULg; Bauduin, Aline; Henin, Jean-Marc et al

Report (2012)

La convention RF 09/6216 WOODPACKTREAT, subventionnée par le Service Public Fédéral, c’est déroulée du 01-02-2010 au 31-03-2012. L’objectif de ce projet consistait à élaborer une méthode standardisée de ... [more ▼]

La convention RF 09/6216 WOODPACKTREAT, subventionnée par le Service Public Fédéral, c’est déroulée du 01-02-2010 au 31-03-2012. L’objectif de ce projet consistait à élaborer une méthode standardisée de traitement sanitaire des bois d’emballage à l’aide de micro-ondes en déterminant, en fonction des caractéristiques du bois, les modalités du traitement requis afin de garantir une mortalité de 100% des ravageurs/pathogènes présents. De manière plus spécifique, les objectifs étaient au nombre de quatre : 1. étudier la relation existante entre la température de surface (Ts), facilement contrôlable, et la température au coeur du bois (Tc) lorsque les caractéristiques de planches varient (épaisseur, humidité, masse volumique et température initiale) ; 2. vérifier la stabilité de la relation Tc-Ts en fonction de la puissance du rayonnement, de la durée de l’exposition et de la charge de bois dans le four ; 3. contrôler le taux de mortalité des organismes placés dans les conditions de Ts qui garantissent 60° C à coeur pendant 60 secondes à l’issue du traitement ; 4. s’assurer de la faisabilité technique du procédé qui sera mis au point, de sa rentabilité, ainsi que son potentiel d’intégration dans une chaîne de fabrication. Un four à micro-ondes de 2,5 GHz dont la puissance pouvait variée de 0 à 28,8 kW fut utilisé. Les planches prises pour les expériences mesuraient 80 X 20 X 2,2 cm. L’ensemble des objectifs n’ont pas pus être menés à bien en raisons de problèmes survenus au four (notamment la découverte d’une répartition non homogène des micro-ondes). Toutefois, un certain nombre de résultat ont put être trouvés, dont voici les principaux: 1. La relation entre les Ts et les Ts n’est significativement influencée que par le type d’essence (la température et l’humidité initiale n’ont pas d’influences significatives). La Ts nécessaire pour avoir dans 99 % des cas une Tc au minimal de 60 °C est de 68 °C pour le peuplier et de 72,5 °C pour le pin. 2. Pour une même énergie incidente, l’élévation de la T est influencée par la durée d’exposition aux rayonnements. Plus la durée est importante, plus le rendement est meilleur. Ce dernier atteint au bout d’un certain temps une valeur limite. La charge du four influence également le rendement. Plus il y a de masse dans le four, plus le rendement est élevé. 3. Le stade de développement d’ Hylotrupes bajulus L. (espèce de référence en matière d’essais de traitement biocide préventif ou curatif du bois) le plus résistant aux micro-ondes ainsi que sa température létale ont été déterminés. Les larves de plus de 150 mg sont les plus résistantes. Une température de 69,7°C garanti 99,99683% de mortalité (taux imposé par l’annexe 1 de l’ISPM 15). 4. Le procédé semble techniquement réalisable. Il semble, par contre, financièrement peu rentable. Toutefois, cette situation pourrait changer avec un durcissement des normes. Suite à ces constatations, il est prévu, au cours d’une convention SPW & ULg: de mettre au point et de valider, en fonction des caractéristiques du bois, le programme de traitement (60°C pendant 60 secondes) ; de vérifier sur des larves d’H. bajulus la létalité du traitement micro-onde établi ; d’évaluer la possible intégration du processus dans une chaîne de production industrielle. [less ▲]

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See detail3D thermo-elastic distortion measurements on OSIRIS SiC hardware by holographic interferometry and correlation with finite element models
Thizy, Cédric ULg; Eliot, Fabienne; Ballhause, Dirk et al

Conference (2012, March)

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See detailAnalysis of tobacco mainstream smoke by GC×GC TOFMS
Brokl, Michal ULg; Bishop, Louise; Wright, Christopher et al

Poster (2012, March)

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See detailBricolage Planning: Understanding Planning in a Fragmented City
Farah, Jihad ULg; Teller, Jacques ULg

in Polyzos, Serafeim (Ed.) Urban Development (2012)

Planning today is a field in reconstruction where new ways of thinking and making the city are experienced. It is trying to deal with the increasing fragmentation of space and society that is challenging ... [more ▼]

Planning today is a field in reconstruction where new ways of thinking and making the city are experienced. It is trying to deal with the increasing fragmentation of space and society that is challenging its efficacy - even its relevance. In this chapter, by relying on Actor-Network Theory's concepts and case studies of Beirut's suburbs, we observe and analyze new practices, tools and efforts made to charter new ways for gathering resources and organizing collective action. In these case studies, we can see that in a fragmented city and on a local level, urban development initiatives are not necessarily chaotic juxtapositions of autonomous projects. Local networks including different kinds of actors may well be in action. These local networks represent laboratories experimenting governance arrangements, urban planning tools and territory building strategies by using at-hand resources and know-how. We call this planning approach Bricolage Planning. [less ▲]

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See detailLa libre circulation des personnes dans et vers l'Union européenne: année 2011
Carlier, Jean-Yves ULg

in Journal de Droit Européen [=JDE] (2012), 20(187), 85-92

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See detailHubert Juin
Stienon, Valérie ULg

in Mathis-Moser, Ursula; MERTZ-BAUMGARTNER, Birgit (Eds.) Passages et ancrages en France. Dictionnaire des écrivains migrants de langue française (1981-2011) (2012)

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See detailThe instability strip of ZZ Ceti white dwarfs I. Introduction of time-dependent convection
Van Grootel, Valérie ULg; Dupret, Marc-Antoine ULg; Fontaine, Gilles et al

in Astronomy and Astrophysics (2012), 539

Aims. The determination of the location of the theoretical ZZ Ceti instability strip in the log g − Teff diagram has remained a challenge over the years due to the lack of a suitable treatment for ... [more ▼]

Aims. The determination of the location of the theoretical ZZ Ceti instability strip in the log g − Teff diagram has remained a challenge over the years due to the lack of a suitable treatment for convection in these stars. For the first time, a full nonadiabatic approach including time-dependent convection is applied to ZZ Ceti pulsators, and we provide the appropriate details related to the inner work- ings of the driving mechanism at work. Methods. We used the nonadiabatic pulsation code MAD with a representative evolutionary sequence of a 0.6 M⊙ DA white dwarf. This sequence is made of state-of-the-art models that include a detailed modeling of the feedback of convection on the atmospheric structure. The assumed convective efficiency in these models is the so-called ML2/α = 1.0 version. We also carried out, for comparison purposes, nonadiabatic computations within the frozen convection approximation, as well as calculations based on models with standard grey atmospheres. Results. We find that pulsational driving in ZZ Ceti stars is concentrated at the base of the superficial H convection zone, but at depths, near the blue edge of the instability strip, somewhat larger than those obtained with the frozen convection approach. Despite the fact that this approach is formally invalid in such stars, particularly near the blue edge of the instability strip, the predicted boundaries are not dramatically different in both cases. The revised blue edge for a 0.6 M⊙ model is found to be around Teff = 11,970 K, some 240 K hotter than the value predicted within the frozen convection approximation, in rather good agreement with the empirical value. On the other hand, our predicted red edge temperature for the same stellar mass is only about 5600 K (80 K hotter than with the frozen convection approach), much lower than the observed value. Conclusions. We correctly understand the development of pulsational instabilities of a white dwarf as it cools at the blue edge of the ZZ Ceti instability strip. Our current implementation of time-dependent convection however still lacks important ingredients to fully account for the observed red edge of the strip. We will explore a number of possibilities in the future papers of this series. [less ▲]

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