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See detailMise au point d’une méthode de traitement par micro-ondes des bois d’emballage destinés à l’exportation comme alternative aux mesures phytosanitaires actuellement appliquées (bromure de méthyle et traitement thermique).
Leyman, Michaël ULg; Bauduin, Aline; Henin, Jean-Marc et al

Report (2012)

La convention RF 09/6216 WOODPACKTREAT, subventionnée par le Service Public Fédéral, c’est déroulée du 01-02-2010 au 31-03-2012. L’objectif de ce projet consistait à élaborer une méthode standardisée de ... [more ▼]

La convention RF 09/6216 WOODPACKTREAT, subventionnée par le Service Public Fédéral, c’est déroulée du 01-02-2010 au 31-03-2012. L’objectif de ce projet consistait à élaborer une méthode standardisée de traitement sanitaire des bois d’emballage à l’aide de micro-ondes en déterminant, en fonction des caractéristiques du bois, les modalités du traitement requis afin de garantir une mortalité de 100% des ravageurs/pathogènes présents. De manière plus spécifique, les objectifs étaient au nombre de quatre : 1. étudier la relation existante entre la température de surface (Ts), facilement contrôlable, et la température au coeur du bois (Tc) lorsque les caractéristiques de planches varient (épaisseur, humidité, masse volumique et température initiale) ; 2. vérifier la stabilité de la relation Tc-Ts en fonction de la puissance du rayonnement, de la durée de l’exposition et de la charge de bois dans le four ; 3. contrôler le taux de mortalité des organismes placés dans les conditions de Ts qui garantissent 60° C à coeur pendant 60 secondes à l’issue du traitement ; 4. s’assurer de la faisabilité technique du procédé qui sera mis au point, de sa rentabilité, ainsi que son potentiel d’intégration dans une chaîne de fabrication. Un four à micro-ondes de 2,5 GHz dont la puissance pouvait variée de 0 à 28,8 kW fut utilisé. Les planches prises pour les expériences mesuraient 80 X 20 X 2,2 cm. L’ensemble des objectifs n’ont pas pus être menés à bien en raisons de problèmes survenus au four (notamment la découverte d’une répartition non homogène des micro-ondes). Toutefois, un certain nombre de résultat ont put être trouvés, dont voici les principaux: 1. La relation entre les Ts et les Ts n’est significativement influencée que par le type d’essence (la température et l’humidité initiale n’ont pas d’influences significatives). La Ts nécessaire pour avoir dans 99 % des cas une Tc au minimal de 60 °C est de 68 °C pour le peuplier et de 72,5 °C pour le pin. 2. Pour une même énergie incidente, l’élévation de la T est influencée par la durée d’exposition aux rayonnements. Plus la durée est importante, plus le rendement est meilleur. Ce dernier atteint au bout d’un certain temps une valeur limite. La charge du four influence également le rendement. Plus il y a de masse dans le four, plus le rendement est élevé. 3. Le stade de développement d’ Hylotrupes bajulus L. (espèce de référence en matière d’essais de traitement biocide préventif ou curatif du bois) le plus résistant aux micro-ondes ainsi que sa température létale ont été déterminés. Les larves de plus de 150 mg sont les plus résistantes. Une température de 69,7°C garanti 99,99683% de mortalité (taux imposé par l’annexe 1 de l’ISPM 15). 4. Le procédé semble techniquement réalisable. Il semble, par contre, financièrement peu rentable. Toutefois, cette situation pourrait changer avec un durcissement des normes. Suite à ces constatations, il est prévu, au cours d’une convention SPW & ULg: de mettre au point et de valider, en fonction des caractéristiques du bois, le programme de traitement (60°C pendant 60 secondes) ; de vérifier sur des larves d’H. bajulus la létalité du traitement micro-onde établi ; d’évaluer la possible intégration du processus dans une chaîne de production industrielle. [less ▲]

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See detailStrontium ranelate uncouples bone formation from bone resorption in male osteoporotic patients
COLLETTE, Julien ULg; Reginster, Jean-Yves ULg

in Osteoporosis International (2012, March), 23(S2), 365-366

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See detailAnalysis of tobacco mainstream smoke by GC×GC TOFMS
Brokl, Michal ULg; Bishop, Louise; Wright, Christopher et al

Poster (2012, March)

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See detailThe instability strip of ZZ Ceti white dwarfs I. Introduction of time-dependent convection
Van Grootel, Valérie ULg; Dupret, Marc-Antoine ULg; Fontaine, Gilles et al

in Astronomy and Astrophysics (2012), 539

Aims. The determination of the location of the theoretical ZZ Ceti instability strip in the log g − Teff diagram has remained a challenge over the years due to the lack of a suitable treatment for ... [more ▼]

Aims. The determination of the location of the theoretical ZZ Ceti instability strip in the log g − Teff diagram has remained a challenge over the years due to the lack of a suitable treatment for convection in these stars. For the first time, a full nonadiabatic approach including time-dependent convection is applied to ZZ Ceti pulsators, and we provide the appropriate details related to the inner work- ings of the driving mechanism at work. Methods. We used the nonadiabatic pulsation code MAD with a representative evolutionary sequence of a 0.6 M⊙ DA white dwarf. This sequence is made of state-of-the-art models that include a detailed modeling of the feedback of convection on the atmospheric structure. The assumed convective efficiency in these models is the so-called ML2/α = 1.0 version. We also carried out, for comparison purposes, nonadiabatic computations within the frozen convection approximation, as well as calculations based on models with standard grey atmospheres. Results. We find that pulsational driving in ZZ Ceti stars is concentrated at the base of the superficial H convection zone, but at depths, near the blue edge of the instability strip, somewhat larger than those obtained with the frozen convection approach. Despite the fact that this approach is formally invalid in such stars, particularly near the blue edge of the instability strip, the predicted boundaries are not dramatically different in both cases. The revised blue edge for a 0.6 M⊙ model is found to be around Teff = 11,970 K, some 240 K hotter than the value predicted within the frozen convection approximation, in rather good agreement with the empirical value. On the other hand, our predicted red edge temperature for the same stellar mass is only about 5600 K (80 K hotter than with the frozen convection approach), much lower than the observed value. Conclusions. We correctly understand the development of pulsational instabilities of a white dwarf as it cools at the blue edge of the ZZ Ceti instability strip. Our current implementation of time-dependent convection however still lacks important ingredients to fully account for the observed red edge of the strip. We will explore a number of possibilities in the future papers of this series. [less ▲]

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See detailStrontium ranelate reduces the number of radiological or radioclinical progressors in patients with primary knee osteoarthritis
Reginster, Jean-Yves ULg; Chapurlat, R; Christiansen, C et al

in Osteoporosis International (2012, March), 23(S2), 366-367

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See detailAu-delà des limites. Focus sur quatre maisons d’édition alternatives bruxelloises
Paques, Frédéric ULg

in Lectures : La Revue des Bibliothèques (2012), 175

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See detailRELIABILITY OF ANALYTICAL METHODS’ RESULTS: A BAYESIAN APPROACH TO ANALYTICAL METHOD VALIDATION
Rozet, Eric ULg; Govaerts, B.; Lebrun, Pierre ULg et al

Conference (2012, March)

Methods validation is mandatory in order to assess the fitness of purpose of the developed analytical method. Of core importance at the end of the validation is the evaluation of the reliability of the ... [more ▼]

Methods validation is mandatory in order to assess the fitness of purpose of the developed analytical method. Of core importance at the end of the validation is the evaluation of the reliability of the individual results that will be generated during the routine application of the method. Regulatory guidelines provide a general framework to assess the validity of a method, but none address the issue of results reliability. In this study, a Bayesian approach is proposed to address this concern. Results reliability is defined here as “the probability ()π of an analytical method to provide analytical results within predefined acceptance limits ()X()λ± around their reference or conventional true concentration values ()Tμ over a defined concentration range and under given environmental and operating conditions.” By providing the minimum reliability probability (minπ needed for the subsequent routine application of the method, as well as specifications or acceptance limits ()λ±, the proposed Bayesian approach provides the effective probability of obtaining reliable future analytical results over the whole concentration range investigated. This is summarized in a single graph: the reliability profile. This Bayesian reliability profile is also compared to two frequentist approaches, the first one derived from the work of Dewé et al. [1] and the second proposed by Govaerts et al. [2]. Furthermore, the applicability of the Bayesian reliability profile is shown using as example the validation of a bioanalytical method dedicated to the determination of ketoglutaric acid (KG) and hydroxymethylfurfural (HMF) in human plasma by SPE-HPLC-UV. [1] Dewé W., Govaerts B., Boulanger B., Rozet E., Chiap P., Hubert Ph., Chemometr. Intell. Lab. Syst. 85 (2007) 262-268. [2] B. Govaerts, W. Dewé, M. Maumy, B. Boulanger, Qual. Reliab. Engng. Int. 24 (2008) 667-680. [less ▲]

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See detailStrontium ranelate and risk of venous thromboembolism (VTE) : an update of a retrospective cohort study in the UK general practice research database (GPRD)
Cooper, C; Deltour, N; Speirs, C et al

in Osteoporosis International (2012, March), 23(S2), 364-365

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See detailVers une politique active du patrimoine dans le SDER nouveau
Fisher, Axel ULg; Goossens, Marc ULg; Occhiuto, Rita ULg et al

in Cahiers Nouveaux (Les) (2012), 81

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See detailWhat are the most important medication attributes for patients with osteoporosis ? Results from a qualitative study
Hiligsmann, Mickaël ULg; Van Durme, C; Geusens, P et al

in Osteoporosis International (2012, March), 23(S2), 81-82

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See detailNon invasive neurostimulation for headaches.
MAGIS, Delphine ULg

Conference (2012, March)

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See detailCharacterization of synovial angiogenesis in osteoarthritis patients and its modulation by chondroitin sulfate
Lambert, Cécile ULg; Mathy-Hartert, Marianne; Dubuc, JE et al

in Arthritis Research & Therapy (2012), 14(2), 58

INTRODUCTION: This work aimed at comparing the production of inflammatory and pro- and anti-angiogenic factors by normal/reactive (N/R) or inflammatory (I) areas of the osteoarthritic synovial membrane ... [more ▼]

INTRODUCTION: This work aimed at comparing the production of inflammatory and pro- and anti-angiogenic factors by normal/reactive (N/R) or inflammatory (I) areas of the osteoarthritic synovial membrane. The effects of interleukin (IL)-1β and chondroitin sulfate (CS) on the expression of pro- and anti-angiogenic factors by synovial fibroblasts cells (SFC) were also studied. METHODS: Biopsies from N/R or from I areas of osteoarthritic synovial membrane were collected at the time of surgery. The inflammatory status of the synovial membrane was characterized by the surgeon according to macroscopic criteria, including the synovial vascularization, the villi formation and the hypertrophic aspect of the tissue. We assessed the expression of CD45, von Willebrand factor and vascular endothelial growth factor (VEGF) antigen by immunohistochemistry in both N/R and I biopsies. The production of IL-6, -8, VEGF and thrombospondin (TSP)-1 by N/R or I synovial cells was quantified by ELISA. SFC were cultured in the absence or in the presence of IL-1β (1 ng/ml) and with or without CS (10, 50, 200 μg/ml). Gene expression of pro-angiogenic factors (VEGF, basic fibroblast growth factor (bFGF), nerve growth factor (NGF), matrix metalloproteinase (MMP)-2 and angiopoietin (ang)-1) and anti-angiogenic factors (vascular endothelial growth inhibitor (VEGI), TSP-1 and -2) were determined by real time RT-PCR. Production of VEGI and TSP-1 was also estimated by ELISA. RESULTS: Immunohistochemistry showed the increase of lymphocyte infiltration, vascular density and VEGF expression in I compared to N/R synovial biopsies. Synovial cells from I areas produced more IL-6, IL-8 and VEGF but less TSP-1 than cells isolated from N/R synovial biopsies. The expression of pro-angiogenic factors by SFC was stimulated by IL-1β. A time dependent regulation of the expression of anti-angiogenic factor genes was observed. IL-1β stimulated the expression of anti-angiogenic factor genes but inhibited it after 24 h. CS reversed the inhibitory effect of IL-1β on anti-angiogenic factors, VEGI and TSP-1. CONCLUSIONS: We demonstrated that synovial biopsies from I areas expressed a pro-angiogenic phenotype. IL-1β induced an imbalance between pro- and anti-angiogenic factors in SFC and CS tended to normalize this IL-1β-induced imbalance, providing a new possible mechanism of action of this drug. [less ▲]

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See detailEffect of collagen hydrolysate in articular pain: A 6-month randomized, double-blind, placebo controlled study
Bruyère, Olivier ULg; Zegels, Brigitte ULg; LEONORI, Lorenzo ULg et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 362-363

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See detailPerception, knowledge and use by general practitioners of Belgium of the FRAX tool
Bruyère, Olivier ULg; Nicolet, Delphine ULg; Compère, Stéphanie et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 363-364

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See detailBornage: questions d'actualité et frais
Salvé, Arianne ULg

in Salvé, Arianne (Ed.) Chronique de droit à l'usage des juges de paix et de police (2012)

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See detailLong-term (3 years) reproducibility for the radiological assessment of knee osteoarthritis
DEROISY, Rita ULg; Bruyère, Olivier ULg; Gensburger, Deborah et al

in Osteoporosis International (2012, March), 23(Suppl. 2), 219-220

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