References of "2012"
     in
Bookmark and Share    
Full Text
See detailEjecta around evolved massive stars observed with Herschel
Vamvatira-Nakou, Chloi ULg; Hutsemekers, Damien ULg; Royer, P. et al

Conference (2012, March)

Detailed reference viewed: 20 (9 ULg)
Full Text
Peer Reviewed
See detailEcological review of black-grass (Alopecurus myosuroides Huds.) propagation abilities in relationship with herbicide resistance
Maréchal, Pierre-Yves ULg; Henriet, François; Vancutsem, Françoise ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2012), 16(1),

Alopecurus myosuroides Huds. (vulpin des champs) a toujours été une préoccupation majeure pour les céréaliculteurs et le développement de la résistance aux herbicides n’améliore pas la situation. Cet ... [more ▼]

Alopecurus myosuroides Huds. (vulpin des champs) a toujours été une préoccupation majeure pour les céréaliculteurs et le développement de la résistance aux herbicides n’améliore pas la situation. Cet article de synthèse résume les différents critères impliqués dans les modèles de dispersion d’individus de vulpin des champs au sein d’un champ ou d’une population sensible. Pour ce faire, le cycle complet du vulpin est décrit de la semence à la semence. Depuis le développement végétatif précoce jusqu’à la chute de la graine, chaque étape est décrite en prenant en compte comment la résistance aux herbicides peut influencer ou exercer un impact différent par rapport à des plantes sensibles. [less ▲]

Detailed reference viewed: 94 (7 ULg)
Full Text
Peer Reviewed
See detailCyclophosphamide inhibits the generation and function of CD8(+) regulatory T cells
Conteduca, Giuseppina ULg

in Human Immunology (2012), 73(3), 207-13

CD8(+) regulatory T cells (Treg) and CD4(+)CD25(+) Treg infiltrate human cancers, thus favoring tumor immune escape. Therefore, in the setting of antitumor therapeutic protocols, it is important to ... [more ▼]

CD8(+) regulatory T cells (Treg) and CD4(+)CD25(+) Treg infiltrate human cancers, thus favoring tumor immune escape. Therefore, in the setting of antitumor therapeutic protocols, it is important to associate antitumor treatment with agents that are able to inhibit Treg function. Cyclophosphamide (CY) has been demonstrated to be effective in counteracting CD4(+)CD25(+) Treg activity. Hence, we tested its inhibitory efficacy on human CD8(+) Treg. Because CY is a prodrug, 4-hydroperoxycyclophosphamide (4-HC), a derivative of CY that in aqueous solution is converted to 4-hydroxycyclophosphamide, an active metabolite of CY, was used. 4-HC significantly inhibited CD8(+) Treg generation and function but only at the higher tested concentration (0.5 μg/mL), that is, in the therapeutic range of the drug. The lower 4-HC concentration tested (0.1 μg/mL) was almost ineffective. 4-HC inhibitory effects were related to apoptosis/necrosis induction. When CD8(+)CD28(+) non-Treg were analyzed for comparative purposes, significantly lower cytotoxic rates among these cells were observed than among CD8(+) Treg, which were differentiated because they did not express the CD28 molecule. These data demonstrate that CD8(+) Treg are inhibited through cytotoxic phenomena by CY, thus supporting the use of this drug at adequate concentrations and schedules of administration as a Treg inhibitor in combinatorial chemo- or immunotherapeutic anticancer protocols. [less ▲]

Detailed reference viewed: 9 (0 ULg)
See detailCarte hydrogéologique de Wallonie, Louveigné-Spa; 49/3-4, 1/25.000 : [notice explicative]
Ruthy, Ingrid ULg; Dassargues, Alain ULg

Book published by Service Public de Wallonie, DGARNE - Version provisoire : mars 2012 (2012)

Detailed reference viewed: 5 (1 ULg)
Full Text
Peer Reviewed
See detailDexamethasone pretreatment provides antiinflammatory and myocardial protection in neonatal arterial switch operation.
Heying, Ruth; Wehage, Edith; SCHUMACHER, Katharina ULg et al

in Annals of Thoracic Surgery (2012), 93(3), 869-76

BACKGROUND: This prospective double-blinded randomized study tested the hypothesis that preoperative treatment with dexamethasone would attenuate inflammatory priming of the myocardium, reduce the ... [more ▼]

BACKGROUND: This prospective double-blinded randomized study tested the hypothesis that preoperative treatment with dexamethasone would attenuate inflammatory priming of the myocardium, reduce the systemic inflammatory reaction upon cardiac operation, and provide organ protection in neonates. METHODS: Twenty neonates (age, 8 to 21 days) with transposition of the great arteries scheduled for arterial switch operation were included. Nine received dexamethasone (1 mg/kg body weight) 4 hours before cardiopulmonary bypass, and 11 received natrium chloride. We studied intramyocardial messenger RNA expression of interleukin (IL)-6, IL-8, IL-1beta, and tumor necrosis factor-alpha (TNF-alpha), as well as IL-10 and expression of TNF-alpha on protein level in right atrial tissue taken before institution of CPB. We measured plasma levels of IL-6, IL-10, lipopolysaccharide binding protein, and cardiac troponin T. Cytokine expression was related to postoperative outcome. RESULTS: Pretreatment with dexamethasone led to a significant decrease in myocardial expression of IL-6, IL-8, IL-1beta, and TNF-alpha messenger RNA and to a decrease in protein synthesis of TNF-alpha. Plasma concentrations of IL-6 were significantly lower and those of IL-10 significantly higher in pretreated patients. This was associated with lower cardiac troponin T values and lower dobutamine requirement. Levels of lipopolysaccharide binding protein were significantly higher postoperatively in pretreated neonates. CONCLUSIONS: Dexamethasone administration before arterial switch operation leads to a shift in the myocardial and systemic cytokine expression profile in neonates with transposition of the great arteries, with downregulation of proinflammatory and upregulation of antiinflammatory cytokines. Lower myocardial cell damage and lower catecholamine requirement suggest myocardial protection in treated patients. [less ▲]

Detailed reference viewed: 46 (14 ULg)
Full Text
See detailContribution à l’étude du formulaire des traités d’alliance entre Rome et les cités grecques
Famerie, Etienne ULg

Scientific conference (2012, March)

La mise en série des traités d’alliance conclus entre Rome et les cités grecques permet de substantiels progrès dans l’établissement et l’interprétation des textes. Après la « clause de majesté » ... [more ▼]

La mise en série des traités d’alliance conclus entre Rome et les cités grecques permet de substantiels progrès dans l’établissement et l’interprétation des textes. Après la « clause de majesté », récemment étudiée (CCG, 20, 2011), le cas de la clause modificative retiendra l’attention. Un nouvel examen des traités avec Méthymne et Astypalaia engage notamment à revoir ce qu’on pourrait appeler la « théorie des clauses annexées ». [less ▲]

Detailed reference viewed: 31 (0 ULg)
Full Text
Peer Reviewed
See detailAMP-activated protein kinase controls liposaccharide-induced hyperpermeability
Castanares-Zapatero, Diego; Overtus, M; Communi, Didier et al

in Critical Care (2012, March), 16(suppl 1), 17

Organ dysfunction determines the severity of sepsis and is correlated to mortality. Endothelial increased permeability contributes to the development of organ failure. AMP-activated protein kinase (AMPK ... [more ▼]

Organ dysfunction determines the severity of sepsis and is correlated to mortality. Endothelial increased permeability contributes to the development of organ failure. AMP-activated protein kinase (AMPK) has been shown to modulate cytoskeleton and could mediate endothelial permeability. Our hypothesis is that AMPK controls sepsis-induced hyperpermeability in the heart and is involved in septic cardiomyopathy. Sepsis was induced by intraperitoneal injection of liposaccharide, 10 mg/kg (LPS). Alpha-1 AMPK knockout mice (α1KO) were compared with wild-type. Vascular permeability was characterized by Evans blue extravasation. Inflammatory cytokine mRNA expression was determined by qPCR analysis. Left ventricular mass was assessed by echocardiography. In addition, to emphasize the beneficial role of AMPK on heart vascular permeability, AMPK activator (acadesine) was administered to C57Bl6 mice before LPS injection. The ANOVA test with Bonferroni's post hoc test and the log-rank test were used. P < 0.05 was considered as significant. Increased cardiac vascular permeability was observed in the LPS group in comparison to untreated animals (2.5% vs. 16%; P < 0.05). The α1KO mice exhibited an increase vascular permeability after LPS injection in comparison to wild-type mice (41.5% vs. 16%; P < 0.05). α1KO animals had a significant mortality increase after LPS injection (70% vs. 10%; P < 0.05). LPS markedly induced the production of proinflammatory cytokines (TNFα, IL-1β, IL-6) that were significantly higher in the α1KO animals. More importantly, LPS treatment leads to an increased left ventricular mass in the α1KO mice within 24 hours, suggesting the onset of edema. Finally LPS-induced vascular hyperpermeability was greatly reduced after AMPK activation by acadesine (13.2% vs. 40%; P < 0.05). AMPK importantly regulates cardiac vascular permeability and could control the sepsis-induced cardiomyopathy. AMPK could represent a new pharmacological target of sepsis. [less ▲]

Detailed reference viewed: 37 (4 ULg)
Full Text
See detailFrom direct to inverse analysis in flexible multibody dynamics
Bruls, Olivier ULg

Conference (2012, March)

Today, state-of-the-art simulation packages in flexible multibody dynamics allow the high-fidelity analysis of industrial mechanisms and machines in many application fields including robotics, automotive ... [more ▼]

Today, state-of-the-art simulation packages in flexible multibody dynamics allow the high-fidelity analysis of industrial mechanisms and machines in many application fields including robotics, automotive systems, aeronautics, deployable structures or wind turbines. The dynamic response of a given system can thus be evaluated in the time-domain for given load cases and given initial values. However, in many practical cases, the engineer does not have a precise knowledge of the mechanical design, the loading conditions and the initial state. This situation occurs for example in structural optimization, optimal control, experimental identification and health monitoring problems. The complexity of simulation codes and the computational cost of high-fidelity models are still important obstacles for the development of efficient resolution methods for these inverse problems. A current challenge is thus to elaborate simplified and more efficient modelling strategies in flexible multibody dynamics in order to enable the development of inverse analysis methods. The talk is divided into three parts. The first part provides an overview of available simulation techniques for flexible mechanisms with a particular emphasis on finite element-based approaches and time integration methods. Some illustrations are presented in the fields of deployable structures, vehicle dynamics and wind turbines. In the second part, optimization problems in flexible multibody dynamics are addressed and solved using gradient-based methods. Efficient methods for sensitivity analysis are discussed and special problems are treated such as the structural optimization of mechanical components or the numerical solution of inverse dynamics problems. The third part discusses a recently-developed Lie group approach which allows the formulation of the equations of motion of a multibody system in a parameterization-free setting. Based on this general formalism, which is characterized by an increased modularity and a reduced complexity, a large variety of Lie group solvers are foreseen not only for time integration but also for model reduction, sensitivity analysis and optimization. [less ▲]

Detailed reference viewed: 81 (9 ULg)
Full Text
Peer Reviewed
See detailClinical Tools for A Personalized Treatment Strategy in Depression.
Desseilles, Martin ULg; Witte, Janet; Trina, E. Chang et al

in Current Psychiatry (2012), 11(3), 26-33

Detailed reference viewed: 11 (1 ULg)
Peer Reviewed
See detailHubert Juin
Stienon, Valérie ULg

in Mathis-Moser, Ursula; MERTZ-BAUMGARTNER, Birgit (Eds.) Passages et ancrages en France. Dictionnaire des écrivains migrants de langue française (1981-2011) (2012)

Detailed reference viewed: 16 (1 ULg)
Full Text
Peer Reviewed
See detailA Hybrid IP Lookup Architecture with Fast Updates
Luo, Layong; Xie, Gaogang; Xie, Yingke et al

in Annual International Conference on Computer Communications (2012, March)

As network link rates are being pushed beyond 40 Gbps, IP lookup in high-speed routers is moving to hardware. The TCAM (Ternary Content Addressable Memory)-based IP lookup engine and the SRAM (Static ... [more ▼]

As network link rates are being pushed beyond 40 Gbps, IP lookup in high-speed routers is moving to hardware. The TCAM (Ternary Content Addressable Memory)-based IP lookup engine and the SRAM (Static Random Access Memory)- based IP lookup pipeline are the two most common ways to achieve high throughput. However, route updates in both engines degrade lookup performance and may lead to packet drops. Moreover, there is a growing interest in virtual IP routers where more frequent updates happen. Finding solutions that achieve both fast lookup and low update overhead becomes critical. In this paper, we propose a hybrid IP lookup architecture to address this challenge. The architecture is based on an efficient trie partitioning scheme that divides the Forwarding Information Base (FIB) into two prefix sets: a large disjoint leaf prefix set mapped into an external TCAM-based lookup engine and a small overlapping prefix set mapped into an on-chip SRAM-based lookup pipeline. Critical optimizations are developed on both IP lookup engines to reduce the update overhead. We show how to extend the proposed hybrid architecture to support virtual routers. Our implementation shows a throughput of 250 million lookups per second (MLPS). The update overhead is significantly lower than that of previous work and the utilization ratio of most external TCAMs is up to 100%. [less ▲]

Detailed reference viewed: 105 (18 ULg)
Peer Reviewed
See detailFoodborne Outbreak by a Recombinant Norovirus GIIg/1 Strain in a University Hospital in Munich
Hoffmann, Dieter; Mauroy, Axel ULg; Foley, Brian et al

Poster (2012, March)

Detailed reference viewed: 52 (1 ULg)
Full Text
See detailAu-delà des mauvaises pratiques autour du développement touristique local; Quelques réflexions sur le cadre théorique de "community based tourism"
Schmitz, Serge ULg

in Azzi, Hrou (Ed.) Tourisme rural et développement des territoires. La région de l'Oriental marocain, une destination touristique (2012, March)

Detailed reference viewed: 139 (33 ULg)
Full Text
See detailFair Trade Organizations and Social Enterprise. Social Innovation through Hybrid Organization Models
Huybrechts, Benjamin ULg

Book published by Routledge (2012)

For several decades, Fair Trade Social Enterprises (FTSEs) have set up partnerships with producer groups in the South and distributed the latter’s products through different types of channels in the North ... [more ▼]

For several decades, Fair Trade Social Enterprises (FTSEs) have set up partnerships with producer groups in the South and distributed the latter’s products through different types of channels in the North. However, while pioneers in the early years were relatively homogeneous (nonprofit organizations relying on voluntary work and selling through “worldshops”), organizational diversity has tremendously increased in recent times, including other types of legal forms, architectures, and governance models (volunteer-based, manager-based, multi-stakeholder, etc.). As a result, different categories of FTSEs now coexist in the sector with diverse missions and strategies. Since Fair Trade (FT) is a hybrid concept, entailing economic, social and political dimensions, the diversity of organizational models might reflect or enable different ways of articulating these dimensions. In other words, different organizational models might be suited for different ways of conceiving and practicing FT. Such an articulation through specific forms has been suggested by previous concepts that can be related to FT, such as cooperatives, the social economy, the solidarity economy, and, more recently, social enterprise. The latter is particularly useful as an umbrella concept that embraces the diverse types of FTSEs and accounts for their use of market mechanisms to pursue social innovation. This research first aims to explore and to structure FTSEs’ organizational diversity. For that purpose, the managers of 57 FTSEs were interviewed in four European regions: Belgium, France (Rhône-Alpes), the United Kingdom (England) and Italy (Rome). Based on the combinations of different elements of the organizational form, five categories emerge: individual FTSEs; entrepreneurial, business-form FTSEs; volunteer-based FTSEs; multi-stakeholder cooperative FTSEs; and group structures. Although certain FTSEs share features corresponding to several models, these categories seem adequate in the sense are relatively homogeneous and distinct from each other. The second question examines the factors or forces that lead FTSEs to adopt particular and diverse organizational forms. Using sociological and economic “new institutional” approaches, this book explores the influence of a number of factors on the organizational form: age, size, region, goals, activities, resources, and leaders’ profiles. From an economic standpoint, organizational diversity may be explained by the fact that FTSEs do not all produce the same types of goods when practicing FT. Thus, FTSEs will adopt the organizational form that minimizes their transaction costs in the production of particular goods. From a sociological standpoint, the analysis suggests that weak and sometimes conflicting institutional pressures explain organizational diversity. Indeed, uniformity is limited (within certain generations of FTSEs or in particular regions), although there is a dominant trend toward a stronger business orientation in the models. The third question examines how organizational actors within FTSEs experience and foster hybridity at the field level, thereby contributing to organizational diversification. Looking at six cases of FTSEs covering the different types of models, the strategic role of FTSEs is examined, as “institutional entrepreneurs” capable of influencing the environment in a way that legitimizes their own organizational model and secures their access to crucial resources. This strategic analysis allows for a more dynamic view of organizational models as “institutional bricolage”. Finally, the book ends with a number of recommendations for FT entrepreneurs on the strengths and the weaknesses of each organizational model. [less ▲]

Detailed reference viewed: 587 (19 ULg)