References of "2012"
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See detailWhen should we measure vitamin D concentration in clinical pratice?
Souberbielle, Jean-Claude; Courbebaisse, Marie; Cormier, Catherine et al

in Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum (2012), 72(suppl 243), 129-135

The many recently published data on vitamin D have raised much interest in the medical community. One of the consequences has been a great increase in the prescription of vitamin D concentration ... [more ▼]

The many recently published data on vitamin D have raised much interest in the medical community. One of the consequences has been a great increase in the prescription of vitamin D concentration measurements in clinical practice. It must be reminded that only the measurement of 25-hydroxyvitamin D (25(OH)D) concentration is indicated to evaluate vitamin D status. Furthermore, since vitamin D insuffi ciency is so common, since treatment is inexpensive and has a large safety margin, and since we already have much data suggesting that besides its classic effects on bone and mineral metabolism, vitamin D may potentially be helpful for the prevention/management of several diseases, perhaps should it be prescribed to everyone without prior testing? In our opinion, there are however groups of patients in whom estimation of vitamin D status is legitimate and may be recommended. This includes patients in whom a “ reasonably ” evidence-based target concentration (i.e., based on randomized clinical trials when possible) should be achieved and/or maintained such as patients with rickets/osteomalacia, osteoporosis, chronic kidney disease and kidney transplant recipients, malabsorption, primary hyperparathyroidism, granulomatous disease, and those receiving treatments potentially inducing bone loss. Other patients in whom vitamin D concentration may be measured are those with symptoms compatible with a severe vitamin D defi ciency or excess persisting without explanation such as those with diffuse pain, or elderly individuals who fall, or those receiving treatments which modify vitamin D metabolism such as some anti-convulsants. Measurement of Vitamin D concentrations should also be part of any exploration of calcium/phosphorus metabolism which includes measurement of serum calcium, phosphate and PTH. [less ▲]

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See detailThe Venus nitric oxide nightglow vertical distribution : update, new features and modelling
Stiepen, Arnaud ULg; Gérard, Jean-Claude ULg; Soret, Lauriane ULg et al

Poster (2012, April)

Ultraviolet (UV) spectra of the delta (190-240 nm) and gamma (225-270 nm) bands of the nitric oxide (NO) molecule have been measured in the atmosphere of the Venus night side with the Spectroscopy for ... [more ▼]

Ultraviolet (UV) spectra of the delta (190-240 nm) and gamma (225-270 nm) bands of the nitric oxide (NO) molecule have been measured in the atmosphere of the Venus night side with the Spectroscopy for Investigation of Characteristics of the Atmosphere of Venus (SPICAV) instrument on board Venus Express (VEX). Excited NO molecules on the night side of the planet find their source in the radiative recombinaison of O(3P) and N(4S) atoms produced on the dayside by Extreme Ultraviolet (EUV) solar photons that cause photodissociation of CO2 and N2 molecules. We analyse with an improved statistics the behaviour of the vertical emission profile of the NO nightglow. We also present a method used to retrieve and analyse the volume emission rate. We describe the dependence of the vertical distribution with latitude and local time and its variability. New features in the vertical distribution of the NO emission such as double peaks are also exhibited. Furthermore, we use a one-dimensional chemical-diffusive model to compare the major features of the calculated O2 1.27 microm and NO UV emissions profiles with those observed with SPICAV. [less ▲]

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See detailHigher-Moment Risk Exposures in Hedge Funds
Lambert, Marie ULg; Hübner, Georges ULg; Papageorgiou, Nicolas

Conference (2012, April)

The paper singles out the key roles of US equity skewness and kurtosis in the determination of the market premia embedded in Hedge Fund returns. We propose a conditional higher-moment asset pricing model ... [more ▼]

The paper singles out the key roles of US equity skewness and kurtosis in the determination of the market premia embedded in Hedge Fund returns. We propose a conditional higher-moment asset pricing model with location, trading and higher-moment factors in order to describe the dynamics of the Equity Hedge (Market Neutral, Short Selling and Long/Short strategies), Event Driven, Relative Value, and Funds of Hedge Funds styles. The volatility, skewness and kurtosis implied in the US options markets are used by Hedge Fund managers as instruments to anticipate market movements. Managers should adjust their market exposure in response to variations in the implied higher moments. We show that higher-moment premia improve a conditional asset pricing model both in terms of explanatory power (R-squares and Schwarz criterion) and specification errors across all Hedge Fund styles. [less ▲]

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See detailRéforme de la mesure générale anti-abus (C.I.R., C. Enr., C. Succ.): commentaires provisoires
Bourgeois, Marc ULg; Nollet, Aymeric ULg

in Leleu, Yves-Henri (Ed.) Chroniques notariales (2012)

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See detailThe in utero and in the postnatal period growth in human newborns
Battisti, Oreste ULg

in Pediatrics & Therapeutics: Current Research (2012)

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See detailAn oblique view on the role of spindle orientation in vertebrate neurogenesis
Peyre, Elise ULg; Morin, Xavier

in Development, Growth & Differentiation (2012)

Neurogenesis is a dynamic process that produces a diverse number of glial and neural cell types from a limited number of neural stem cells throughout development and into adulthood. After an initial ... [more ▼]

Neurogenesis is a dynamic process that produces a diverse number of glial and neural cell types from a limited number of neural stem cells throughout development and into adulthood. After an initial period of amplification through symmetric division, neural stem cells rely on asymmetric modes of division to self-renew while producing more committed progeny. Understanding the molecular mechanisms regulating the choice between symmetric and asymmetric modes of division is essential to understand human brain development and pathologies, and to explain the increasing cortical complexity observed in evolution. A popular model states the existence of a causal relationship between the orientation of the axis of division of stem cells and the fate of their progeny in many different tissues, but the validity of the model in neural stem cells is not clear. In this review, we briefly present the diversity of neural stem cells and intermediate progenitors in the developing central nervous system. We then draw a historic overview of the assumed causal relationship between spindle orientation and fate determination. We show how this prompted a search for regulators of spindle orientation, and present the current state of knowledge on the mechanism. Finally, we review data on the effect of defective spindle orientation and try to integrate conflicting observations by presenting alternative mechanisms that may regulate the choice between symmetric and asymmetric outcomes. [less ▲]

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See detailChronique - Cour de Justice et Tribunal de l'Union européenne - Concurrence
Petit, Nicolas ULg; Lousberg, Charlotte ULg

in Journal du Droit International - Clunet (2012), (2), 747-759

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See detailTyrosine-dependent capture of CAP-Gly domain‐containing proteins in complex mixture by EB1 C-terminal peptidic probes
Calligaris, David ULg; Manatschal, Cristina; Marcellin, Marlène et al

in Journal of Proteomics (2012), 75

Microtubule dynamics is regulated by an array of microtubule associated proteins of which the microtubule plus-end tracking proteins (+TIPs) are prominent examples. +TIPs form dynamic interaction networks ... [more ▼]

Microtubule dynamics is regulated by an array of microtubule associated proteins of which the microtubule plus-end tracking proteins (+TIPs) are prominent examples. +TIPs form dynamic interaction networks at growing microtubule ends in an EB1-dependent manner. The interaction between the C-terminal domain of EB1 and the CAP-Gly domains of the +TIP CLIP-170 depends on the last tyrosine residue of EB1. In the present study, we generated peptidic probes corresponding to the C-terminal tail of EB1 to affinity-capture binding partners from cell lysates. Using an MS-based approach, we showed that the last 15 amino-acid residues of EB1, either free or immobilized on beads, bound recombinant CAP-Gly domains of CLIP-170. We further demonstrate that this binding was prevented when the C-terminal tyrosine of EB1 was absent in the peptidic probes. Western blotting in combination with a label-free quantitative proteomic analysis revealed that the peptidic probe harboring the C-terminal tyrosine of EB1 effectively pulled-down proteins with CAP-Gly domains from endothelial cell extracts. Additional proteins known to interact directly or indirectly with EB1 and the microtubule cytoskeletonwere also identified. Our peptidic probes represent valuable tools to detect changes induced in EB1-dependent +TIP networks by external cues such as growth factors and small molecules. [less ▲]

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See detailLe régime alimentaire du Martin-pêcheur huppé Alcedo cristata pendant la période de reproduction dans la région de Kinshasa (R.D. Congo)
Kisasa Kafutshi, Robert ULg

in Malimbus (2012), 34

The diet of the Malachite Kingfisher was investigated by study of 182 regurgitated pellets collected from 65 broods during the nesting period in the rainy seasons from 2004 to 2009, in two sites in the ... [more ▼]

The diet of the Malachite Kingfisher was investigated by study of 182 regurgitated pellets collected from 65 broods during the nesting period in the rainy seasons from 2004 to 2009, in two sites in the Kinshasa area. In total, 2619 undigested remains were identified in the pellets, revealing 1100 prey. The Malachite Kingfisher’s diet is rich and diverse. The prey identified were 92.7 % fishes (Oreochromis niloticus, Gambusia affinis and Hemichromis elongatus), 5.9 % insects (Odonata and Orthoptera) and 0.5 % frogs. [less ▲]

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See detailInfluence of drying and hydrothermal treatment of corn on the denaturation of salt-soluble proteins and color parameters
Odjo, Sylvanus; Malumba Kamba, Paul ULg; Dossou, Joseph et al

in Journal of Food Engineering (2012), 109(3), 561-570

The effect of heat treatments (drying and hydrothermal treatment) on the extractability of salt-soluble protein (SSP) was assessed using Promatest methodology for corn kernels heated between 60 C and 120 ... [more ▼]

The effect of heat treatments (drying and hydrothermal treatment) on the extractability of salt-soluble protein (SSP) was assessed using Promatest methodology for corn kernels heated between 60 C and 120 C. During drying, the evolution of the grain moisture content is fitted using the analytical solution of Fick equation developed by Crank (1979) for spherical material. The decrease of extractible salt-soluble protein during heating is forecasted using a first and a second order ordinary differential equation. It was found that temperature; moisture content and time of processing greatly influence the kinetic denaturation of SSP of corn kernels. The evolution of extractible SSP content of corn kernels during drying at high temperature is more correctly described with second order kinetic than with the first order kinetic reaction. The Hunterlab color parameters of corn also vary during drying. Lightness and color intensity decrease while yellowness, redness, chroma and hue angle increase through drying time. Most of these Hunterlab color parameters are highly correlated with the salt-soluble proteins content and therefore could be used as indicators of excessive heat treatment and denaturation of salt-soluble proteins in corn kernels [less ▲]

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See detailEnjeux, obstacles et atouts d'un modèle de soins aux contours indéterminés
Thunus, Sophie ULg

in Revue de l'Observatoire (2012), 72

Cette contribution porte sur les enjeux que soulève la réforme des soins de santé mentale en Belgique, au carrefour de l’évolution socio-historique du secteur, et d’un modèle des soins inscrit au sein de ... [more ▼]

Cette contribution porte sur les enjeux que soulève la réforme des soins de santé mentale en Belgique, au carrefour de l’évolution socio-historique du secteur, et d’un modèle des soins inscrit au sein de tendances internationales. Précisément, l’objectif est de mettre en tension l’indétermination du modèle, au sens où il renvoie à un ensemble d’expériences étrangères plus qu’un un corpus de savoirs; et la configuration d’une offre de soins encore déterminée par ses frontières institutionnelles. [less ▲]

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See detailMechanical Ventilation During Anaesthesia: Pathophysiology and Clinical Implications
Dresse, Caroline; JORIS, Jean ULg; HANS, Grégory ULg

in Trends in Anaesthesia and Critical Care (2012), 2(2), 71-75

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See detailSuccessions internationales: perspectives d'avenir
Rosoux, Hélène ULg

in Leleu, Yves-Henri (Ed.) Chroniques notariales, vol. 55 (2012)

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See detailETAPE - Rapport d’évaluation des résultats
Vanmeerbeek, Marc ULg; Bednarek, Stéphanie; Lachaussée, Sophie et al

Report (2012)

Contexte et objectifs ETAPE est un programme d’intervention précoce à domicile au bénéfice de familles à risque de négligence parentale. Le programme prend en charge des enfants de 0 à 30 mois, ainsi que ... [more ▼]

Contexte et objectifs ETAPE est un programme d’intervention précoce à domicile au bénéfice de familles à risque de négligence parentale. Le programme prend en charge des enfants de 0 à 30 mois, ainsi que leurs parents, au rythme d’une à deux visites à domicile par semaine. L’intervention consiste en des massages du bébé, des jeux psychomoteurs. Un temps important est en outre consacré à l’accompagnement et à la guidance du rôle parental. L’originalité du projet est qu’il est centré sur le développement psychomoteur et affectif du bébé en lien avec son ou ses parents. L’étude cherche à mesurer l’efficacité du programme en termes de développement psychomoteur de l’enfant, de qualité d’attachement au sein de la dyade parent-enfant et de compétences éducatives des parents. Méthodologie Les aptitudes psychomotrices de l’enfant ont été mesurées au moyen du test de Brunet et Lézine modifié, au début, en milieu et en fin d’intervention. Le caractère sécure ou non de l’attachement a été mesuré chez le caregiver par Q-Sort en début et en fin d’intervention. Les compétences parentales ont été évaluées tous les six mois durant l’intervention au moyen d’un questionnaire développé par l’équipe de recherche en 2008 (MASPIN) et complété par les intervenants sur base de leurs observations. Résultats Douze enfants ont été étudiés. Les trois quarts ont été pris en charge avant 1 an ; la durée moyenne d’intervention est de 11,3 mois. En moyenne, les enfants gagnent nettement en score de développement moteur global, gagnent un peu en socialisation, sont stables en développement moteur fin. La plupart régressent au score de langage, ce qui influence négativement le score global de développement. Deux enfants sur douze sont sécures au début et à la fin de l’intervention (mais ce ne sont pas les mêmes). Aucun ne termine l’intervention significativement insécurisé, mais la relation dans la dyade n’est en général pas optimale. Les résultats de MASPIN permettent d’étoffer les autres résultats obtenus et de mieux comprendre l’évolution au cas par cas. Discussion Les résultats, mesurés par les tests de Brunet-Lézine et le Q-Sort semblent modestes dans certains domaines, mais doivent être analysés à la lumière des conditions d’intervention. MASPIN a donné une vue beaucoup plus précise de la réalité et de son évolution. Ce questionnaire a aussi permis de monitorer l’intervention. Toutefois, la finesse des observations et l’aspect subjectif de la cotation empêchent une analyse globale des résultats ; la fidélité intercotateur doit encore être validée. MASPIN permet en outre de donner des repères pour le dialogue avec d’autres professionnels impliqués dans le suivi des situations, et fournit un canevas qui facilite la discussion avec les familles sur l’exercice de la parentalité et les objectifs d’intervention. L’analyse des résultats permet de prendre conscience que certaines compétences (par ex., le langage) méritent d’être mieux soutenues et stimulées par les intervenants de terrain.) Des collaborations extérieures devront être développées (par ex : psychologue, aide sociale). L’investissement requis de la part des intervenants est important. Le risque de découragement est grand ; ils doivent être soutenus et supervisés de façon efficace dans ce travail. L’instauration d’un vrai esprit d’équipe est indispensable Conclusion Le rendement de ce programme, destiné à un public particulièrement difficile, est intéressant mais variable selon les situations prises en charge, que ce soit en termes de développement psychomoteur ou d’attachement à la figure parentale. L’outil MASPIN se révèle précieux dans de multiples aspects de la prise en charge, depuis le dialogue avec les professionnels qui identifient la situation, jusqu’au monitorage des objectifs au fil de l’intervention, en passant par la construction des objectifs d’intervention avec les parents. [less ▲]

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See detailAutomated procedures in ISO17025 routine dioxin laboratory: impact on throughput
Focant, Jean-François ULg

Scientific conference (2012, April)

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See detailL1-based compression of random forest models
Joly, Arnaud ULg; Schnitzler, François ULg; Geurts, Pierre ULg et al

in 20th European Symposium on Artificial Neural Networks (2012, April)

Random forests are effective supervised learning methods applicable to large-scale datasets. However, the space complexity of tree ensembles, in terms of their total number of nodes, is often prohibitive ... [more ▼]

Random forests are effective supervised learning methods applicable to large-scale datasets. However, the space complexity of tree ensembles, in terms of their total number of nodes, is often prohibitive, specially in the context of problems with very high-dimensional input spaces. We propose to study their compressibility by applying a L1-based regularization to the set of indicator functions defined by all their nodes. We show experimentally that preserving or even improving the model accuracy while significantly reducing its space complexity is indeed possible. [less ▲]

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See detailLes polémiques autour de la littérature jeunesse, ou la quête sans cesse rejouée de la légitimité
Barnabé, Fanny ULg

in COnTEXTES : Revue de Sociologie de la Littérature (2012), (10),

Cet article analyse les enjeux dissimulés derrière une polémique qui a débuté suite à un article de François Busnel, publié le 24 novembre 2010 dans l’Express-Lire, dans lequel ce dernier dénigre la ... [more ▼]

Cet article analyse les enjeux dissimulés derrière une polémique qui a débuté suite à un article de François Busnel, publié le 24 novembre 2010 dans l’Express-Lire, dans lequel ce dernier dénigre la littérature jeunesse et l’accuse de n’être qu’un "coup marketing". Cette publication a déclenché de nombreuses réactions chez les représentants de ce secteur. L'analyse proposée ici tâche de rendre compte, en confrontant les deux types de prises de parole, de l’impact que peut avoir l’objet d'une polémique (la littérature jeunesse, dans ce cas-ci) sur le déroulement de celle-ci. [less ▲]

Detailed reference viewed: 90 (8 ULg)