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See detailLe vemurafenib, une avancée majeure dans le traitement du mélanome métastatique exprimant le BRAF V600E
EL HAYDERI, Lara ULg; RORIVE, Andrée ULg; NIKKELS, Arjen ULg

in Skin Inc (2012)

Malgré une sensibilisation de la population concernant les dangers du soleil, des techniques diagnostiques très sensibles comme la dermoscopie et une diminution constante de l'épaisseur des mélanomes lors ... [more ▼]

Malgré une sensibilisation de la population concernant les dangers du soleil, des techniques diagnostiques très sensibles comme la dermoscopie et une diminution constante de l'épaisseur des mélanomes lors du premier diagnostic, il existe toujours des cas où le diagnostic arrive trop tard. Le pronostic du mélanome métastatique (stade IV) reste alors péjoratif avec une survie n'excédant pas les 5% à 5 ans. Les traitements par agents chimiothérapeutiques comme le DTIC (dacarbazine), les immunothérapies comme l'interféron ou les vaccinations à base de cellules dendritiques ne donnent que très peu d'espoir dans cette indication. Heureusement, des avancées significatives sont rapportées dans le traitement du mélanome métastatique exprimant la mutation BRAF V600E avec un inhibiteur de la BRAF kinase, le vemurafinib. Les résultats d'une étude de phase III montrent une diminution de 63 % du risque de décès et de 74 % du risque de progression avec le vemurafenib, par rapport à la chimiothérapie par DTIC. Le vemurafenib est associé à de nombreux effets indésirables cutanés (rash, alopécie, kérato-acanthome, carcinomes spinocellulaires, photosensibilité ...), qu'il est important de reconnaître pour pouvoir assurer une prise en charge thérapeutique adéquate. [less ▲]

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See detailHigh-resolution spectropolarimetric observations of hot subdwarfs
Petit, P.; Van Grootel, Valérie ULg; Bagnulo, S. et al

in Leaflet - Astronomical Society of the Pacific (2012, March 01), 452

We report on high-resolution spectropolarimetric observations of the hot subdwarf stars HD 76431 and Feige 66, using the ESPaDOnS echelle spectropolarimeter at CFHT. We compute cross-correlation Stokes I ... [more ▼]

We report on high-resolution spectropolarimetric observations of the hot subdwarf stars HD 76431 and Feige 66, using the ESPaDOnS echelle spectropolarimeter at CFHT. We compute cross-correlation Stokes I and V line profiles to enhance the signal-to-noise ratio. We then average all available cross-correlation profiles of each star to further decrease the noise level. Although both targets were previously reported to host kilo-gauss magnetic fields, we do not derive any evidence of large-scale photospheric fields from our sets of observations, in spite of tight error bars on the longitudinal field of the order of 60 gauss for HD 76431 and 200 gauss for Feige 66. A new analysis of FORS1 observations of HD 76431, which provided the basis for the original claim of field detection, confirms the absence of any detectable Zeeman signature, with an error bar of about 100 gauss on the longitudinal magnetic field. [less ▲]

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See detailUtilisation d'une composition comme attractant d'auxiliaires
Leroy, Pascal; Sabri, Ahmed; Heuskin, Stéphanie ULg et al

Patent (2012)

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See detailLe G1000: Trois défis méthodologiques
Reuchamps, Min ULg; Dodeigne, Jérémy ULg; Claisse, Frédéric ULg

Scientific conference (2012, March 01)

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See detailmédiation, technique, communication
Servais, Christine ULg

Conference (2012, March 01)

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See detailPlanetary transit candidates in the CoRoT-SRc01 field
Erikson, A.; Santerne, A.; Renner, S. et al

in Astronomy and Astrophysics (2012), 539

Context. The space mission CoRoT is devoted to the analysis of stellar variability and the photometric detection of extrasolar planets. <BR /> Aims: We present the list of planetary transit candidates ... [more ▼]

Context. The space mission CoRoT is devoted to the analysis of stellar variability and the photometric detection of extrasolar planets. <BR /> Aims: We present the list of planetary transit candidates detected in the first short run observed by CoRoT that targeted SRc01, towards the Galactic center in the direction of Aquila, which lasted from April to May 2007. <BR /> Methods: Among the acquired data, we analyzed those for 1269 sources in the chromatic bands and 5705 in the monochromatic band. Instrumental noise and the stellar variability were treated with several detrending tools, to which several transit-search algorithms were subsequently applied. <BR /> Results: Fifty-one sources were classified as planetary transit candidates and 26 were followed up with ground-based observations. Until now, no planet has been detected in the CoRoT data from the SRc01 field. The CoRoT space mission, launched on December 27th 2006, has been developed and is operated by CNES, with contributions from Austria, Belgium, Brazil, ESA, Germany, and Spain. The CoRoT data are available to the community from the CoRoT archive: <A href="http://idoc-corot.ias.u-psud.fr">http://idoc-corot.ias.u-psud.fr</A>Based in part on observations made with the 1.93-m telescope at Observatoire de Haute Provence (CNRS), France (SOPHIE Program 08A.PNP.MOUT).Based in part on observations made with the ESO-3.60-m telescope at La Silla Observatory (ESO), Chile (HARPS Program ESO - 081.C-0388) and with the ESO-VLT telescope at Paranal Observatory (ESO), Chile (FLAMES Program ESO - 081.C-0413). [less ▲]

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See detailSelf-assemblage and quorum in the earthworm Eisenia fetida (Oligochaete, Lumbricidae)
Zirbes, Lara ULg; Brostaux, Yves ULg; Mescher, Mark et al

in PLoS ONE (2012), 7(3), 32564

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See detailTechnique(s), médiation et politique - entre Latour, Marx et Heidegger
Pieron, Julien ULg

Conference (2012, March 01)

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See detailRecent disturbances in the Congo Basin : an anthracological contribution to vegetation reconstructions
Morin-Rivat, Julie ULg; Hubau, Wannes; Gillet, Jean-François ULg et al

Poster (2012, March 01)

In contrast to the well-known vegetation history of the northern hemisphere, few is known about past vegetation change in Central Africa. However, recent palaeoecological and biogeographical studies ... [more ▼]

In contrast to the well-known vegetation history of the northern hemisphere, few is known about past vegetation change in Central Africa. However, recent palaeoecological and biogeographical studies suggest that early human disturbances had a substantial influence on Central Africa vegetation patterns, particularly allowing the expansion of light-demanding species. This interesting hypothesis is the basis of one of the main research questions of the ERA-net BIODIVERSA CoForChange project: what was and is the relationship between (increasing) human activity and vegetation change? A recently developed protocol for the identification of ancient Central African charcoal fragments opened the door for vegetation reconstructions with a high spatial and taxonomical resolution. Therefore, we chose to study macro-charcoals from pedoanthracological profiles situated in N Congo and SE Camero0n. In total, 48 taxa were found in nine radiocarbon dated profiles. At the moment, three taxa have been identified down to species level. First, we found numerous fragments of Gilbertiodendron dewevrei under a current monodominant forest of G. dewevrei (40 cm depth, 1421-1327 cal. BP). This seems to confirm the presumption that monodominant forests of G. dewevrei, shade-bearer species, are relatively stable. Second, we evidenced the lack of Triplochiton scleroxylon charcoals under a T. scleroxylon stand, which could confirm the hypothesis of the recent nature of those stands. Finally, our results suggest that taxonomic diversity of charcoal findings in open canopy Marantaceae forests is greater than in dense forests. Pterocarpus soyauxii and Millettia drastica have been found under an open Marantaceae forest at 40 cm depth (1184-1055 cal. BP). The abundance of the light-demanding species P. soyauxii appears to be decreasing over time (levels 20 to 40 cm depth) to the benefit of giant herbs. Anthracology in Central Africa is on the rise and the first results of the CoForChange project are promising. More identifications will follow, resulting in a better understanding of the evolution of Central African forests. [less ▲]

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See detailTests with a Carlina-type diluted telescope. Primary coherencing
Le Coroller, H.; Dejonghe, J.; Regal, X. et al

in Astronomy and Astrophysics (2012), 539

Aims: Studies are under way to propose a new generation of post-VLTI interferometers. The Carlina concept studied at the Haute-Provence Observatory is one of the proposed solutions. It consists in an ... [more ▼]

Aims: Studies are under way to propose a new generation of post-VLTI interferometers. The Carlina concept studied at the Haute-Provence Observatory is one of the proposed solutions. It consists in an optical interferometer configured like a diluted version of the Arecibo radio telescope: above the diluted primary mirror made of fixed cospherical segments, a helium balloon (or cables suspended between two mountains), carries a gondola containing the focal optics. Since 2003, we have been building a technical demonstrator of this diluted telescope. First fringes were obtained in May 2004 with two closely-spaced primary segments and a CCD on the focal gondola. We have been testing the whole optical train with three primary mirrors. The main aim of this article is to describe the metrology that we have conceived, and tested under the helium balloon to align the primary mirrors separate by 5-10 m on the ground with an accuracy of a few microns. Methods: Getting stellar fringes using delay lines is the main difficulty for astronomical interferometers. Carlina does not use delay lines, but the primary segments have to be positioned on a sphere i.e. coherencing the primary mirrors. As described in this paper, we used a supercontinuum laser source to coherence the primary segments. We characterize the Carlina's performances by testing its whole optical train: servo loop, metrology, and the focal gondola. Results: The servo loop stabilizes the mirror of metrology under the helium balloon with an accuracy better than 5 mm while it moves horizontally by 30 cm in open loop by 10-20 km/h of wind. We have obtained the white fringes of metrology; i.e., the three mirrors are aligned (cospherized) with an accuracy of ≈1 μm. We show data proving the stability of fringes over 15 min, therefore providing evidence that the mechanical parts are stabilized within a few microns. This is an important step that demonstrates the feasibility of building a diluted telescope using cables strained between cliffs or under a balloon. Carlina, like the MMT or LBT, could be one of the first members of a new class of telescopes named diluted telescopes. [less ▲]

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See detailModelling European tree species distribution change over the Holocene
Dury, Marie ULg; Dullinger, Stefan; Hülber, Karl et al

Conference (2012, March 01)

The postglacial re-colonization of Europe by temperate tree species from a few glacial refugia during the Holocene (10,000 BP) is a very interesting case to study the mechanisms of the vegetation dynamics ... [more ▼]

The postglacial re-colonization of Europe by temperate tree species from a few glacial refugia during the Holocene (10,000 BP) is a very interesting case to study the mechanisms of the vegetation dynamics. The relative roles that played the climate conditions, the species dispersal capacities and the competition between species in the re-colonization rates remain controversial. We investigate these different aspects with the CARAIB dynamic vegetation model (CARAIB DVM). Transient runs were performed over the Holocene using the HadCM3 AOGCM-reconstructed climate. European-wide species migration at 0.5° x 0.5° is represented in the model using migration rates derived from a high resolution cellular automaton, CATS-UPSCALE. Individual tree species migration rates were pre-calculated with CATS-UPSCALE every 1000 years over each grid cell used by the DVM in the climatic conditions reconstructed by the AOGCM. The impacts of competition on plant dispersal are not taken into account by the automaton. Thus, in CARAIB, a function has been constructed to reduce the potential CATS migration rates in competition conditions. It is based on the species dispersal kernel and on the net primary productivity of the different species present on the grid cell. The migration of one species, from its 10,000 BP refugia, is studied within a landscape defined by a set of other species for which no dispersal limitations are assumed. Here, we illustrate the results obtained for two wind-dispersed (Abies alba and Picea abies) and for a no wind-dispersed (Fagus sylvatica) tree species. The speeds and the paths of the postglacial spread obtained with the DVM are compared to the past distributions of the three species reconstructed from pollen and macrofossil data. The Holocene climate conditions simulated by the HadCM3 AOGCM do not constrain the European re-colonization of the studied species, except in Scandinavia at the beginning of the period for Picea abies. We observe that, during the past 10,000 years, species occupied regions where climate conditions were different from present observed species climate requirements, notably in the 10k species refugia. This result may imply that at present the species do not occupy their potential distribution area and thus that the postglacial re-colonization is not completed yet. We also show that species dispersal capacities cannot explain the observed species migration over the Holocene and that competition has played an important role. Indeed, when we use the potential migration rates (no competition), species spread too fast. [less ▲]

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See detailExposé introductif
Husson, Jean-François ULg

Speech (2012)

Cet exposé introductif au séminaire de l'Association Internationale des Maires Francophones aborde les antagonismes économiques et sociaux, sans négliger la dimension religieuse. La seconde partie de l ... [more ▼]

Cet exposé introductif au séminaire de l'Association Internationale des Maires Francophones aborde les antagonismes économiques et sociaux, sans négliger la dimension religieuse. La seconde partie de l'exposé traite du rôle des élus locaux et des instruments à leur disposition. [less ▲]

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See detail"L'avenir de l'enseignement du français langue étrangère"
Defays, Jean-Marc ULg

Conference given outside the academic context (2012)

Detailed reference viewed: 12 (0 ULg)
See detailL’éducation des filles dans les couvents au XVIIIe siècle
Henneau, Marie-Elisabeth ULg

Conference (2012, March 01)

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See detailHow pristine is the Congo Basin forest ? Some answers from Erythrophleum spp. (Caesalpiniaceae) and Pericopsis elata (Fabaceae) natural stands in southeastern Cameroon
Bourland, Nils ULg; Livingstone Smith, Alexandre; Guion, Hélène ULg et al

Poster (2012, March 01)

Erythrophleum spp. and Pericopsis elata are two important African timber taxa suffering from regeneration problems. Those light demanding trees could have established in openings made by past human ... [more ▼]

Erythrophleum spp. and Pericopsis elata are two important African timber taxa suffering from regeneration problems. Those light demanding trees could have established in openings made by past human activities (mainly slash-and-burn cultivation). Our study aimed at verifying this assumption in a 340,000 ha forest concession in southeastern Cameroon. Anthracological excavations were made alongside transects opened in patches where those taxa occur as well as the surrounding environment. Numerous charcoal elements and some pottery fragments were found in excavated soils in all studied sites. Charcoals and pieces of pottery were found within the first 100 and 50 cm of soil, respectively. According to radiocarbon dating conducted on charcoals and burnt seeds, fires occurred between 2,150 to 195 years BP. This finding was consistent with the analysis of archaeological materials decoration techniques. Our results revealed intense past anthropological activities in this area, seriously questioning the assumption of a pristine Congo Basin [less ▲]

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