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See detailTyrosine-dependent capture of CAP-Gly domain‐containing proteins in complex mixture by EB1 C-terminal peptidic probes
Calligaris, David ULg; Manatschal, Cristina; Marcellin, Marlène et al

in Journal of Proteomics (2012), 75

Microtubule dynamics is regulated by an array of microtubule associated proteins of which the microtubule plus-end tracking proteins (+TIPs) are prominent examples. +TIPs form dynamic interaction networks ... [more ▼]

Microtubule dynamics is regulated by an array of microtubule associated proteins of which the microtubule plus-end tracking proteins (+TIPs) are prominent examples. +TIPs form dynamic interaction networks at growing microtubule ends in an EB1-dependent manner. The interaction between the C-terminal domain of EB1 and the CAP-Gly domains of the +TIP CLIP-170 depends on the last tyrosine residue of EB1. In the present study, we generated peptidic probes corresponding to the C-terminal tail of EB1 to affinity-capture binding partners from cell lysates. Using an MS-based approach, we showed that the last 15 amino-acid residues of EB1, either free or immobilized on beads, bound recombinant CAP-Gly domains of CLIP-170. We further demonstrate that this binding was prevented when the C-terminal tyrosine of EB1 was absent in the peptidic probes. Western blotting in combination with a label-free quantitative proteomic analysis revealed that the peptidic probe harboring the C-terminal tyrosine of EB1 effectively pulled-down proteins with CAP-Gly domains from endothelial cell extracts. Additional proteins known to interact directly or indirectly with EB1 and the microtubule cytoskeletonwere also identified. Our peptidic probes represent valuable tools to detect changes induced in EB1-dependent +TIP networks by external cues such as growth factors and small molecules. [less ▲]

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See detailDu théâtre magique au cinéma fantastique : les figures extatiques de Georges Méliès
Tomasovic, Dick ULg

in Gimello-Mesplomb, Frédéric (Ed.) Le Cinéma fantastique français à l’épreuve du genre fantastique. Socioanalyse d’une production artistique (2012)

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See detailLa population, émergence d'un concept technologique
Oulc'hen, Hervé ULg

in Kiéfer, Audrey; Risse, David (Eds.) La biopolitique outre-Atlantique après Foucault (2012)

In his writings concerned with biopolitics Foucault gives the concept of population a central place and means to find its arising at the crossroads of several types of discourse : particularly about ... [more ▼]

In his writings concerned with biopolitics Foucault gives the concept of population a central place and means to find its arising at the crossroads of several types of discourse : particularly about species and the public. The genealogy of this bifocal concept is in keeping with some aspects of Canguilhem’s epistemological approach to the regulation of milieus, following his work on scientific ideology. Not only does such a parallel enable us to bring out the critical use of biopolitical concepts, it also leads us to examine the technological sequence which has made it possible for the concept of population to be determined. Such a sequence is articulated in three moments – utopia, practice, theory – which enable us to account for the evolution of the technology of police. [less ▲]

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See detailEngineering geological mapping in Wallonia (Belgium) : present state and recent computerized approach
Delvoie, Simon ULg; Radu, Jean-Pol ULg; Ruthy, Ingrid ULg et al

Poster (2012, April)

An engineering geological map can be defined as a geological map with a generalized representation of all the components of a geological environment which are strongly required for spatial planning ... [more ▼]

An engineering geological map can be defined as a geological map with a generalized representation of all the components of a geological environment which are strongly required for spatial planning, design, construction and maintenance of civil engineering buildings. In Wallonia (Belgium) 24 engineering geological maps have been developed between the 70s and the 90s at 1/5,000 or 1/10,000 scale covering some areas of the most industrialized and urbanized cities (Liège, Charleroi and Mons). They were based on soil and subsoil data point (boring, drilling, penetration test, geophysical test, outcrop. . . ). Some displayed data present the depth (with isoheights) or the thickness (with isopachs) of the different subsoil layers up to about 50 m depth. Information about geomechanical properties of each subsoil layer,useful for engineers and urban planners, is also synthesized. However, these maps were built up only on paper and progressively needed to be updated with new soil and subsoil data. The Public Service of Wallonia and the University of Liège have recently initiated a study to evaluate the feasibility to develop engineering geological mapping with a computerized approach. Numerous and various data (about soil and subsoil) are stored into a georelational database (the geotechnical database – using Access, Microsoft®). All the data are geographically referenced. The database is linked to a GIS project (using ArcGIS, ESRI®). Both the database and GIS project consist of a powerful tool for spatial data management and analysis. This approach involves a methodology using interpolation methods to update the previous maps and to extent the coverage to new areas. The location (x, y, z) of each subsoil layer is then computed from data point. The geomechanical data of these layers are synthesized in an explanatory booklet joined to maps. [less ▲]

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See detailEffect of Transient Creep Strain Model on the Behavior of Concrete Columns Subjected to Heating and Cooling
Gernay, Thomas ULg

in Fire Technology (2012), 48(2), 313-329

In the numerical analysis of structures in fire, the material models that are used have important implications on the global behavior of the structure. In concrete, a particular phenomenon appears when ... [more ▼]

In the numerical analysis of structures in fire, the material models that are used have important implications on the global behavior of the structure. In concrete, a particular phenomenon appears when subjected to high temperatures: the transient creep strain. Models integrating explicitly a term for transient creep strain have been proposed in the literature but, in the current Eurocode 2 model, there is no explicit term for transient creep strain. This phenomenon is included in the Eurocode 2 model, but it is implicitly considered in the mechanical strain term. A series of experimental fire tests on axially restrained concrete columns subjected to heating and cooling has been recently performed at South China University of Technology and described by Wu et al. (Fire Technol 46:231–249). In the original paper, it was shown that using the implicit model of Eurocode 2, the behavior of the columns cannot be simulated properly, especially during the cooling phase. The objective of the present paper is to perform again the fire tests simulations using a new formulation of the Eurocode 2 model that contains an explicit term for transient creep. In the first part of the paper, the explicit formulation of the Eurocode 2 model is presented. In the second part, the fire tests are modeled with the software SAFIR using, on the one hand, the implicit Eurocode model and, on the other hand, the new explicit model. It is shown that the transient creep model has significant implications on the global behavior of structural concrete members, as the residual axial load sustained by the columns at the end of the fire can differ by up to 25% of the initial applied load depending on the transient creep strain model that is used for the calculation. The experimental behavior is better matched with the new explicit model than with the current Eurocode model. Particularly, the results given by the Eurocode model during the cooling phase are unconservative as the residual axial load is overestimated. Finally, it is explained why, on the basis of an example, in a performance-based approach, these results can have important implications on the global fire resistance of a structure. [less ▲]

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See detailLa médiation scolaire. Un regard des acteurs sur leurs pratiques
Kuty, Olgierd ULg; Schoenaers, Frédéric ULg; Dubois, Christophe ULg et al

Book published by Presses Universitaires de Liège (2012)

Dans nos sociétés en réseaux qui se caractérisent par un pluralisme normatif, on peut faire société sans partager des valeurs communes. Le fonctionnement des institutions scolaires illustre les nouveaux ... [more ▼]

Dans nos sociétés en réseaux qui se caractérisent par un pluralisme normatif, on peut faire société sans partager des valeurs communes. Le fonctionnement des institutions scolaires illustre les nouveaux modes de régulation des tensions, de la diversité, de l'intégration, etc. désormais à l’œuvre. C'est dans ce contexte que le concept de médiation a fait son apparition dans nos écoles, comme dispositif d'apaisement ou de maintien du lien social. La diffusion de tels dispositifs doit beaucoup à la création de services centraux puis locaux de médiation, tout comme au travail de nombreux médiateurs qui ont progressivement investi le champ scolaire. Cet ouvrage constitue une exploration du développement de leur fonction et il rend compte de la culture professionnelle qui les anime. Cette exploration conduit à s'interroger sur le processus de diffusion de la médiation scolaire tout en contextualisant cette dernière dans le spectre plus large de la médiation en général, un concept désormais répandu dans les champs familiaux, judiciaires, sanitaires, administratifs, politiques et sociaux les plus divers. [less ▲]

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See detailThe earthquake sedimentary record in marine sediment from cores in the western part of the Marmara Sea, Turkey
Drab, Laureen; Hubert, Aurelia ULg; Schmidt, Sabine et al

Conference (2012, April)

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See detailDegradation inhibitors and metal additives: impact on solvent degradation
Léonard, Grégoire ULg

Report (2012)

This report is part of a PhD thesis currently taking place at the University of Liège in collaboration with the company Laborelec. A Degradation Test Rig (DTR) has been built in order to evaluate solvent ... [more ▼]

This report is part of a PhD thesis currently taking place at the University of Liège in collaboration with the company Laborelec. A Degradation Test Rig (DTR) has been built in order to evaluate solvent degradation in CO2 capture conditions. Details about degradation effects and about the DTR may be found in a previous report (PhD mid-term report, G. Léonard, 2011). Experiments to study the effect of process conditions on degradation are in progress with 2-ethanolamine (MEA) as benchmark solvent. This report presents first a brief overview of the different degradation mechanisms and associated products, followed by a literature review about metal influence on MEA degradation and a state of the art review about degradation inhibitors. [less ▲]

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See detailModelling the risk of ecosystem disruption in Europe with a dynamic vegetation model
Dury, Marie ULg; Hambuckers, Alain ULg; Warnant, Pierre et al

Conference (2012, April)

What will be the European ecosystem responses to future climate? With unprecedented speed and extent, the projected climate change might lead to a disruption of terrestrial plants functioning in many ... [more ▼]

What will be the European ecosystem responses to future climate? With unprecedented speed and extent, the projected climate change might lead to a disruption of terrestrial plants functioning in many regions. In the framework of the EcoChange project, transient projections over the 1901-2100 period have been performed with a process-based dynamic vegetation model, CARAIB DVM (Dury et al., 2011, iForest 4: 82, 99). The vegetation model was driven by the outputs of four climate models under the SRES A1B scenario: the ARPEGE/Climate model and three regional climate models (KNMI-RACMO2 , DMI-HIRHAM5 and HC-HadRM3Q0 RCMs) from the European Union project ENSEMBLES. DVMs are appropriate tools to apprehend potential climate change impacts on ecosystems and identify threatened regions over Europe. CARAIB outputs (soil moisture, runoff, net primary productivity, fire, etc.) were used to characterize the ecosystem evolution. To assess consequences on biodiversity, the evolution of 100 natural common European species (47 herbs, 12 shrubs and 41 trees) has been studied year-to-year over the 1901-2100 period. Under the combined effects of projected changes particularly in temperature and precipitations, CARAIB simulates important reductions in the annual soil water content. The species productivities vary strongly from year to year reaching during the driest years values much lower than present-day average productivity. According to CARAIB, a lot of species might go beyond their water tolerance very frequently, particularly after 2050, due to more intense summer droughts. In the northern part of Europe and in the Alps, with reduced temperature variability and positive soil water anomalies, NPP variability tends to decrease. Regions with more severe droughts might also be affected by an increase of the frequency and intensity of wildfires. With this background, the species distributions might be strongly modified. 15% of tree species and 30% of herb and shrub species (respectively 30% and 60% if the CO2 fertilization effect on species is not taken into account) might experience a loss of 30% or more of their current distribution. Proportions of new species appearance at the end of the century were also studied. Southern Europe might suffer important species extinction while the more suitable climate conditions in northern Europe might lead to a gain in species diversity. [less ▲]

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See detailLes polémiques autour de la littérature jeunesse, ou la quête sans cesse rejouée de la légitimité
Barnabé, Fanny ULg

in COnTEXTES : Revue de Sociologie de la Littérature (2012), (10),

Cet article analyse les enjeux dissimulés derrière une polémique qui a débuté suite à un article de François Busnel, publié le 24 novembre 2010 dans l’Express-Lire, dans lequel ce dernier dénigre la ... [more ▼]

Cet article analyse les enjeux dissimulés derrière une polémique qui a débuté suite à un article de François Busnel, publié le 24 novembre 2010 dans l’Express-Lire, dans lequel ce dernier dénigre la littérature jeunesse et l’accuse de n’être qu’un "coup marketing". Cette publication a déclenché de nombreuses réactions chez les représentants de ce secteur. L'analyse proposée ici tâche de rendre compte, en confrontant les deux types de prises de parole, de l’impact que peut avoir l’objet d'une polémique (la littérature jeunesse, dans ce cas-ci) sur le déroulement de celle-ci. [less ▲]

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See detailWhen should we measure vitamin D concentration in clinical pratice?
Souberbielle, Jean-Claude; Courbebaisse, Marie; Cormier, Catherine et al

in Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum (2012), 72(suppl 243), 129-135

The many recently published data on vitamin D have raised much interest in the medical community. One of the consequences has been a great increase in the prescription of vitamin D concentration ... [more ▼]

The many recently published data on vitamin D have raised much interest in the medical community. One of the consequences has been a great increase in the prescription of vitamin D concentration measurements in clinical practice. It must be reminded that only the measurement of 25-hydroxyvitamin D (25(OH)D) concentration is indicated to evaluate vitamin D status. Furthermore, since vitamin D insuffi ciency is so common, since treatment is inexpensive and has a large safety margin, and since we already have much data suggesting that besides its classic effects on bone and mineral metabolism, vitamin D may potentially be helpful for the prevention/management of several diseases, perhaps should it be prescribed to everyone without prior testing? In our opinion, there are however groups of patients in whom estimation of vitamin D status is legitimate and may be recommended. This includes patients in whom a “ reasonably ” evidence-based target concentration (i.e., based on randomized clinical trials when possible) should be achieved and/or maintained such as patients with rickets/osteomalacia, osteoporosis, chronic kidney disease and kidney transplant recipients, malabsorption, primary hyperparathyroidism, granulomatous disease, and those receiving treatments potentially inducing bone loss. Other patients in whom vitamin D concentration may be measured are those with symptoms compatible with a severe vitamin D defi ciency or excess persisting without explanation such as those with diffuse pain, or elderly individuals who fall, or those receiving treatments which modify vitamin D metabolism such as some anti-convulsants. Measurement of Vitamin D concentrations should also be part of any exploration of calcium/phosphorus metabolism which includes measurement of serum calcium, phosphate and PTH. [less ▲]

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See detailJe d'enfants : le journal réflexif, un outil de régulation des apprentissages
Scheepers, Caroline ULg

in Cahiers des Sciences de l'Education (Les) (2012), 33

La présente contribution envisage ces écrits réflexifs et métacognitifs particuliers que sont les journaux d’apprentissages par le prisme de cette question : l’écrit et l’oral réflexifs peuvent-ils ... [more ▼]

La présente contribution envisage ces écrits réflexifs et métacognitifs particuliers que sont les journaux d’apprentissages par le prisme de cette question : l’écrit et l’oral réflexifs peuvent-ils constituer des outils pertinents au service de l’évaluation diagnostique ? Si oui, comment, à quelles conditions et pourquoi ? Si non, pourquoi ? Dans un premier temps, je clarifie le sens attribué aux concepts-clés de cette problématique, à savoir : réflexivité, métacognition, journal des apprentissages, évaluation diagnostique. Les soubassements épistémologiques de cette recherche sont explicités. Je tâche dans un second temps de répondre aux questions de recherche qui font l’objet de cet article. Pour ce faire, sur un plan méthodologique, je tente de mettre en œuvre une démarche multidisciplinaire, convoquant les apports de disciplines aussi variées que la psychologie cognitive, les sciences de l’éducation, la sociologie, les sciences du langage… [less ▲]

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See detailL'astronomie dans le monde
Manfroid, Jean ULg

Article for general public (2012)

Collision dans le Dragon; Trou noir de masse intermédiaire;Zoom sur une galaxie lointaine; Les jours de Vénus s’allongent ?; Lumière cendrée; Anomalies magnétiques lunaires; Océan martien; Hercule par le ... [more ▼]

Collision dans le Dragon; Trou noir de masse intermédiaire;Zoom sur une galaxie lointaine; Les jours de Vénus s’allongent ?; Lumière cendrée; Anomalies magnétiques lunaires; Océan martien; Hercule par le VST [less ▲]

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See detailFIRST, a high dynamic range imager, mounted on the 3-m Shane Telescope
Huby, Elsa ULg

Scientific conference (2012, April)

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See detailLes régimes matrimoniaux en droit international privé - autour de trois questions d'actualité
Wautelet, Patrick ULg

in Revue Droit International Privé = Tijdschrift voor Internationaal Privaatrecht (2012), 11(1), 29-43

Ce papier fait le point sur trois questions d'actualité dans la pratique du droit international privé des régimes matrimoniaux. Ces questions ont été sélectionnées parce qu'elles peuvent également se ... [more ▼]

Ce papier fait le point sur trois questions d'actualité dans la pratique du droit international privé des régimes matrimoniaux. Ces questions ont été sélectionnées parce qu'elles peuvent également se poser dans d'autres domaines du droit international privé : il s'agit d'abord de la distinction entre questions de forme et questions de fond, ensuite de l'appréhension et du fonctionnement des règles de rattachement fondée sur une échelle de rattachement et enfin de l'application concrète de l'exception d'ordre public [less ▲]

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See detailIntroduction générale
Bouhon, Frédéric ULg; Reuchamps, Min ULg

in Bouhon, Frédéric; Reuchamps, Min (Eds.) Les systèmes électoraux de la Belgique (2012)

Cette introduction ouvre un ouvrage collectif consacré aux systèmes électoraux de la Belgique. Elle insiste sur le caractère multidisciplinaire de l'étude des questions électorales qui est proposée dans ... [more ▼]

Cette introduction ouvre un ouvrage collectif consacré aux systèmes électoraux de la Belgique. Elle insiste sur le caractère multidisciplinaire de l'étude des questions électorales qui est proposée dans le livre et en présente le plan. [less ▲]

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See detailUpdate of the Belgian Association for the Study of the Liver Guidelines for the treatment of chronic hepatitis C genotype 1 with protease inhibitors.
Orlent, H; Deltenre, P; Francque, S et al

in Acta Gastro-Enterologica Belgica (2012), 75(2), 245-259

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