References of "2012"
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See detailRegulation of a-Synuclein Membrane Binding and Its Implications
Chen, Robert; Wislet, Sabine ULg; Mount, Howard et al

in Juliana Dushanova (Ed.) Mechanisms in Parkinson Disease models and treatment (2012)

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See detailQuinze ans d'anti-TNF dans la maladie de Crohn: comment tirer le meilleur de cette revolution therapeutique?
Louis, Edouard ULg; REENAERS, Catherine ULg; Meuwis, Marie-Alice ULg et al

in Revue Médicale de Liège (2012), 67 Spec No

After fifteen years of use, the anti-TNF antibodies have become the corner stone of the treatment of moderate and severe Crohn's disease. The skill acquired over the years through experimental trials and ... [more ▼]

After fifteen years of use, the anti-TNF antibodies have become the corner stone of the treatment of moderate and severe Crohn's disease. The skill acquired over the years through experimental trials and clinical experience leads to increased therapeutic efficacy and minimized risks. These antibodies are introduced increasingly earlier in Crohn's disease as well as in a broader range of patients, aiming at changing the natural history of the diseases by avoiding the development of intestinal tissue damage and complications. [less ▲]

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See detailCharacterization of synovial angiogenesis in osteoarthritis patients and its modulation by chondroitin sulfate
Lambert, Cécile ULg; Mathy-Hartert, Marianne; Dubuc, JE et al

in Arthritis Research & Therapy (2012), 14(2), 58

INTRODUCTION: This work aimed at comparing the production of inflammatory and pro- and anti-angiogenic factors by normal/reactive (N/R) or inflammatory (I) areas of the osteoarthritic synovial membrane ... [more ▼]

INTRODUCTION: This work aimed at comparing the production of inflammatory and pro- and anti-angiogenic factors by normal/reactive (N/R) or inflammatory (I) areas of the osteoarthritic synovial membrane. The effects of interleukin (IL)-1β and chondroitin sulfate (CS) on the expression of pro- and anti-angiogenic factors by synovial fibroblasts cells (SFC) were also studied. METHODS: Biopsies from N/R or from I areas of osteoarthritic synovial membrane were collected at the time of surgery. The inflammatory status of the synovial membrane was characterized by the surgeon according to macroscopic criteria, including the synovial vascularization, the villi formation and the hypertrophic aspect of the tissue. We assessed the expression of CD45, von Willebrand factor and vascular endothelial growth factor (VEGF) antigen by immunohistochemistry in both N/R and I biopsies. The production of IL-6, -8, VEGF and thrombospondin (TSP)-1 by N/R or I synovial cells was quantified by ELISA. SFC were cultured in the absence or in the presence of IL-1β (1 ng/ml) and with or without CS (10, 50, 200 μg/ml). Gene expression of pro-angiogenic factors (VEGF, basic fibroblast growth factor (bFGF), nerve growth factor (NGF), matrix metalloproteinase (MMP)-2 and angiopoietin (ang)-1) and anti-angiogenic factors (vascular endothelial growth inhibitor (VEGI), TSP-1 and -2) were determined by real time RT-PCR. Production of VEGI and TSP-1 was also estimated by ELISA. RESULTS: Immunohistochemistry showed the increase of lymphocyte infiltration, vascular density and VEGF expression in I compared to N/R synovial biopsies. Synovial cells from I areas produced more IL-6, IL-8 and VEGF but less TSP-1 than cells isolated from N/R synovial biopsies. The expression of pro-angiogenic factors by SFC was stimulated by IL-1β. A time dependent regulation of the expression of anti-angiogenic factor genes was observed. IL-1β stimulated the expression of anti-angiogenic factor genes but inhibited it after 24 h. CS reversed the inhibitory effect of IL-1β on anti-angiogenic factors, VEGI and TSP-1. CONCLUSIONS: We demonstrated that synovial biopsies from I areas expressed a pro-angiogenic phenotype. IL-1β induced an imbalance between pro- and anti-angiogenic factors in SFC and CS tended to normalize this IL-1β-induced imbalance, providing a new possible mechanism of action of this drug. [less ▲]

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See detail3D thermo-elastic distortion measurements on OSIRIS SiC hardware by holographic interferometry and correlation with finite element models
Thizy, Cédric ULg; Eliot, Fabienne; Ballhause, Dirk et al

Conference (2012, March)

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See detailInondations en Wallonie, une fatalité ?
Dewals, Benjamin ULg; Pirotton, Michel ULg

Conference given outside the academic context (2012)

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See detailAu-delà des mauvaises pratiques autour du développement touristique local; Quelques réflexions sur le cadre théorique de "community based tourism"
Schmitz, Serge ULg

in Azzi, Hrou (Ed.) Tourisme rural et développement des territoires. La région de l'Oriental marocain, une destination touristique (2012, March)

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See detailIncidence of Abcd1 level on the induction of cell death and organelle dysfunctions triggered by very long chain fatty acids and TNF-alpha on oligodendrocytes and astrocytes
Baarine, Mauhamad; Ragot, Kevin; Athias, Anne et al

in NeuroToxicology (2012), 33(2)

X-linked adrenoleukodystrophy (X-ALD) is characterized by ABCD1 deficiency. This disease is associated with elevated concentrations of very long chain fatty acids (C24:0 and C26:0) in the plasma and ... [more ▼]

X-linked adrenoleukodystrophy (X-ALD) is characterized by ABCD1 deficiency. This disease is associated with elevated concentrations of very long chain fatty acids (C24:0 and C26:0) in the plasma and tissues of patients. Under its severe form, brain demyelination and inflammation are observed. Therefore, we determined the effects of C24:0 and C26:0 on glial cells:oligodendrocytes, which synthesize myelin, and astrocytes, which participate in immune response. So, 158N murine oligodendrocytes, rat C6 glioma cells, rat primary cultures of neuronal–glial cells, and of oligodendrocytes were treated for various periods of time in the absence or presence of C24:0 and C26:0 used at plasmatic concentrations found in X-ALD patients (1–5 μM) and higher (10, 20, 40 μM). To evaluate the importance of extrinsic and intrinsic factors, the part taken by TNF-α and reduced Abcd1 level was studied. Whatever the cells considered, no effects on cell growth and/or viability were detected at 1–5 μM, more or less pronounced effects were identified at 10 μM, and an induction of cell death with increased permeability to propidium iodide and loss of transmembrane mitochondrial potential was observed at 20–40 μM. On 158N, cell death was characterized by (i) an increased superoxide anion production at the mitochondrial level; (ii) the presence of vacuoles of different sizes and shapes; a destabilization of lysosomal membrane and a cytoplasmic redistribution of lysosomes; (iii) a modulation of Abcd3/PMP70 and Acox-1 protein expression, and a decrease in catalase activity at the peroxisomal level. When TNF-α was combined with C24:0 or C26:0 and used on 158N cells, C6 cells, and on 158N cells after siRNA mediated knockdown of Abcd1, no or slight potentiation was revealed. Thus, on the different cell models used, an induction of cell death with marked cellular dysfunctions at the mitochondrial, lysosomal, and peroxisomal levels were found with C24:0 and C26:0 at 20 μM and higher. However, in our experimental conditions, plasmatic concentrations of these fatty acids were unable to induce cell death, and organelle dysfunctions on oligodendrocytes and astrocytes, and additional intrinsic and environmental factors, such as reduced Abcd1 level and/or TNF-α, were ineffective to potentiate their side effects. [less ▲]

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See detailOud word je niet alleen. Een enquête over eenzaamheid en sociaal isolement bij ouderen in België
Vandenbroucke, S; Lebrun, JM; Vermeulen, B et al

Report (2012)

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See detailÉchecs ou le dynamisme romanesque des puissances immobiles
Demoulin, Laurent ULg

in Demoulin, Laurent (Ed.) Echecs (2012)

Analyse du roman Echecs de Jean-Philippe Toussaint: ce roman de jeunesse est situé dans l’ensemble de l’œuvre du romancier; la genèse de ses différentes versions est retracée; les influences en sont ... [more ▼]

Analyse du roman Echecs de Jean-Philippe Toussaint: ce roman de jeunesse est situé dans l’ensemble de l’œuvre du romancier; la genèse de ses différentes versions est retracée; les influences en sont circonscrites et une réflexion sur sa qualité est menée en vertu d'une comparaison avec les romans ultérieurs. [less ▲]

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See detailUsage de Facebook par les femmes entrepeneures
Cornet, Annie ULg

Conference given outside the academic context (2012)

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See detailEfficacy of once-yearly zoledronic acid 5 mg in men with osteoporosis with different levels of serum total testosterone
Boonen, S; Reginster, Jean-Yves ULg; Kaufman, JM et al

in Osteoporosis International (2012, March), 23(S2), 79-80

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See detailEstimating stellar mean density through seismic inversions
Reese, Daniel ULg; Marques, J. P.; Goupil, M. J. et al

in Astronomy and Astrophysics (2012), 539(A63), 18

Determining the mass of stars is crucial both for improving stellar evolution theory and for characterising exoplanetary systems. Asteroseismology offers a promising way for estimating the stellar mean ... [more ▼]

Determining the mass of stars is crucial both for improving stellar evolution theory and for characterising exoplanetary systems. Asteroseismology offers a promising way for estimating the stellar mean density. When combined with accurate radii determinations, such as are expected from GAIA, this yields accurate stellar masses. The main difficulty is finding the best way to extract the mean density of a star from a set of observed frequencies. We seek to establish a new method for estimating the stellar mean density, which combines the simplicity of a scaling law while providing the accuracy of an inversion technique. We provide a framework in which to construct and evaluate kernel-based linear inversions that directly yield the mean density of a star. We then describe three different inversion techniques (SOLA and two scaling laws) and apply them to the Sun, several test cases and three stars, alpha Cen B, HD 49933 and HD 49385, two of which are observed by CoRoT. The SOLA (subtractive optimally localised averages) approach and the scaling law based on the surface correcting technique described by Kjeldsen et al. (2008, ApJ, 683, L175) yield comparable results that can reach an accuracy of 0.5 % and are better than scaling the large frequency separation. The reason for this is that the averaging kernels from the two first methods are comparable in quality and are better than what is obtained with the large frequency separation. It is also shown that scaling the large frequency separation is more sensitive to near-surface effects, but is much less affected by an incorrect mode identification. As a result, one can identify pulsation modes by looking for an l and n assignment which provides the best agreement between the results from the large frequency separation and those from one of the two other methods. Non-linear effects are also discussed, as is the effects of mixed modes. In particular, we show that mixed modes bring little improvement to the mean density estimates because of their poorly adapted kernels. [less ▲]

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See detailQuel est l’impact de l’interculturel sur les échanges virtuels en entreprise ?
Cusumano, Christophe ULg

Conference (2012, March)

Since the end of the eighties, the globalization and development of new information and communication technologies have played a great part in complicating exchanges between companies and their various ... [more ▼]

Since the end of the eighties, the globalization and development of new information and communication technologies have played a great part in complicating exchanges between companies and their various stakeholders (staff, customers/users and business partners). New forms of organization of work result in more and more relationships between people of different nationalities and cultures. Thanks to virtuality, a lot of companies can develop connections with people from various cultural backgrounds which can be co-located or distributed (with partners situated abroad, including in different time zones). But to maximize this potential, organization must overcome different complexifications levels of virtual communication and multicultural. So, we suggest studying the impact of cultural diversity on the quality and efficiency of virtual communications. There are already many studies about the impact of diversity on non-virtual context but very little about the impact of diversity on virtual exchanges. The originality of this article is to focus on the influence of intercultural and virtuality. [less ▲]

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See detailDecision making in noisy bistable switches A local analysis for non local predictions
Trotta, Laura ULg; Bullinger, Eric ULg; Sepulchre, Rodolphe ULg

Conference (2012, March)

In this paper, we try to estimate some statistics about the decision making process in a bistable model submitted to noise by studying the local properties of the system around an hyperbolic saddle point ... [more ▼]

In this paper, we try to estimate some statistics about the decision making process in a bistable model submitted to noise by studying the local properties of the system around an hyperbolic saddle point. Despite the fact that the saddle is not an equilibrium point of the stochastic system, we show that a local approach is still instructive. Under appropriate assumptions, the system can be reduced to an Orsntein-Uhlenbeck process whose dynamics depend on the properties of the saddle point. Yet, Orstein-Uhlenbeck processes have been used to study decision making under uncertainty in a broad variety of fields including statistics and cognitive neurosciences . [less ▲]

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See detailApproche par compétences et réduction des inégalités d'apprentissage entre élèves
Beckers, Jacqueline ULg; Crinon, Jacques; Simons, Germain ULg

Book published by De Boeck (2012)

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