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See detailDevelopment of a biomechanical model of deer antler cancellous bone based on X-ray microtomographic images
de Bien, Charlotte ULg; Mengoni, Marlène ULg; D'Otreppe, Vinciane ULg et al

in Micro-CT User Meeting 2012 - Abstract Book (2012, April)

Finite element models accurately compute the mechanical response of bone and bone-like materials when the models include their detailed microstructure. The aim of this paper is to develop and validate a ... [more ▼]

Finite element models accurately compute the mechanical response of bone and bone-like materials when the models include their detailed microstructure. The aim of this paper is to develop and validate a biomechanical model for deer antler cancellous bone tissue based on X-ray microtomographic images. In order to simulate the mechanical behavior under compressive load using a finite element model, images obtained by X-ray microtomography were exported into Metafor, which is an non-linear finite element software initially developed at University of Liège for metal forming processes. This software has recently found biomedical applications. The ultimate goal is to compare model predictions with the mechanical behavior observed experimentally using the Skyscan material testing stage under compression mode. The creation of the biomechanical model mesh from segmented μCT images, its integration into the software Metafor and the simulation of a compression test are described in this paper. [less ▲]

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See detailHow does elicitor and antimicrobial fengycin interact with plasma membranes of sensitive cells ?
Nasir, Mehmet Nail ULg; Eeman, Marc; Lins, Laurence ULg et al

Conference (2012, April)

Fengycin is characterized by its strong antifungal and low hemolytic activities. It has also been recently demonstrated that it has plant elicitor properties and is also able to enhance the elicitors’ ... [more ▼]

Fengycin is characterized by its strong antifungal and low hemolytic activities. It has also been recently demonstrated that it has plant elicitor properties and is also able to enhance the elicitors’ activity of surfactin. The cell target of its biological activities is supposed to be plasma membrane. In spite of these interesting biological activities, fengycin has not been extensively investigated probably because of the difficulties related to its production. In a first time; we have characterized the interfacial properties of fengycin by tensiometry measurements and demonstrated that this surface activity was pH-dependent. In a second time; we have investigated the interactions of the lipopeptide with membrane lipids using model membranes such as Langmuir monolayers and multilammelar vesicles (MLVs). Our results indicate that the lipopeptide was able to penetrate into different lipid monolayers showing a preference for sterol-containing monolayers. In order to better understand the mechanism of the interactions of fengycin with membranes at the molecular level, MLVs with or without fengycin have been analyzed by spectroscopic techniques. We have shown that conformational changes of the lipopeptide occurred in the presence of lipids and they were more significant in the presence of sterol. Moreover, tyrosine residues of the lipopeptide seem to play an important role in these interactions. In conclusion, we have determined that the surface-active behavior as well as the conformation of fengycin depends on its environment. We have also showed that the lipopeptide does not interact with all class of lipids in the same way and presents a preference for sterols. The presence of key groups within peptide cycle has also been supposed for the biological activities of the lipopeptide. [less ▲]

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See detailL’homme de lettres en personnage générique. La ‘‘sociologie-fiction’’ des Physiologies
Stienon, Valérie ULg

in Dozo, Björn-Olav; Glinoer, Anthony; Lacroix, Michel (Eds.) Imaginaires de la vie littéraire. Fiction, figuration, configuration (2012)

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See detailLes régimes matrimoniaux en droit international privé - autour de trois questions d'actualité
Wautelet, Patrick ULg

in Revue Droit International Privé = Tijdschrift voor Internationaal Privaatrecht (2012), 11(1), 29-43

Ce papier fait le point sur trois questions d'actualité dans la pratique du droit international privé des régimes matrimoniaux. Ces questions ont été sélectionnées parce qu'elles peuvent également se ... [more ▼]

Ce papier fait le point sur trois questions d'actualité dans la pratique du droit international privé des régimes matrimoniaux. Ces questions ont été sélectionnées parce qu'elles peuvent également se poser dans d'autres domaines du droit international privé : il s'agit d'abord de la distinction entre questions de forme et questions de fond, ensuite de l'appréhension et du fonctionnement des règles de rattachement fondée sur une échelle de rattachement et enfin de l'application concrète de l'exception d'ordre public [less ▲]

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See detailRéponses du Martin-pêcheur huppé Alcedo cristata à la perturbation de ses sites de nidification
Kisasa Kafutshi, Robert ULg

in Malimbus (2012), 34(28-38),

From 2004 to 2009, two colonies of Malachite Kingfisher were monitored by ringing the nestlings and adults, counting eggs and observing parental activity at the nests. Results show that 10 % of nests were ... [more ▼]

From 2004 to 2009, two colonies of Malachite Kingfisher were monitored by ringing the nestlings and adults, counting eggs and observing parental activity at the nests. Results show that 10 % of nests were destroyed by people in the Symphonies site as against 78 % in the Monastery site. Consequently, the number of nests available for breeding is lower at Monastery than at Symphonies. The number of fledged chicks per nest at Symphonies was twice that at the Monastery. Site fidelity is higher for the adults in the Symphonies site (26 %) than at the Monastery (11 %). This suggests that the Monastery site is less favourable to the survival of the Malachite Kingfisher than the Symphonies site. The best strategy to protect this species seems to be the maintenance of a good number of nesting sites. [less ▲]

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See detailTyrosine-dependent capture of CAP-Gly domain‐containing proteins in complex mixture by EB1 C-terminal peptidic probes
Calligaris, David ULg; Manatschal, Cristina; Marcellin, Marlène et al

in Journal of Proteomics (2012), 75

Microtubule dynamics is regulated by an array of microtubule associated proteins of which the microtubule plus-end tracking proteins (+TIPs) are prominent examples. +TIPs form dynamic interaction networks ... [more ▼]

Microtubule dynamics is regulated by an array of microtubule associated proteins of which the microtubule plus-end tracking proteins (+TIPs) are prominent examples. +TIPs form dynamic interaction networks at growing microtubule ends in an EB1-dependent manner. The interaction between the C-terminal domain of EB1 and the CAP-Gly domains of the +TIP CLIP-170 depends on the last tyrosine residue of EB1. In the present study, we generated peptidic probes corresponding to the C-terminal tail of EB1 to affinity-capture binding partners from cell lysates. Using an MS-based approach, we showed that the last 15 amino-acid residues of EB1, either free or immobilized on beads, bound recombinant CAP-Gly domains of CLIP-170. We further demonstrate that this binding was prevented when the C-terminal tyrosine of EB1 was absent in the peptidic probes. Western blotting in combination with a label-free quantitative proteomic analysis revealed that the peptidic probe harboring the C-terminal tyrosine of EB1 effectively pulled-down proteins with CAP-Gly domains from endothelial cell extracts. Additional proteins known to interact directly or indirectly with EB1 and the microtubule cytoskeletonwere also identified. Our peptidic probes represent valuable tools to detect changes induced in EB1-dependent +TIP networks by external cues such as growth factors and small molecules. [less ▲]

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See detailWhen should we measure vitamin D concentration in clinical pratice?
Souberbielle, Jean-Claude; Courbebaisse, Marie; Cormier, Catherine et al

in Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum (2012), 72(suppl 243), 129-135

The many recently published data on vitamin D have raised much interest in the medical community. One of the consequences has been a great increase in the prescription of vitamin D concentration ... [more ▼]

The many recently published data on vitamin D have raised much interest in the medical community. One of the consequences has been a great increase in the prescription of vitamin D concentration measurements in clinical practice. It must be reminded that only the measurement of 25-hydroxyvitamin D (25(OH)D) concentration is indicated to evaluate vitamin D status. Furthermore, since vitamin D insuffi ciency is so common, since treatment is inexpensive and has a large safety margin, and since we already have much data suggesting that besides its classic effects on bone and mineral metabolism, vitamin D may potentially be helpful for the prevention/management of several diseases, perhaps should it be prescribed to everyone without prior testing? In our opinion, there are however groups of patients in whom estimation of vitamin D status is legitimate and may be recommended. This includes patients in whom a “ reasonably ” evidence-based target concentration (i.e., based on randomized clinical trials when possible) should be achieved and/or maintained such as patients with rickets/osteomalacia, osteoporosis, chronic kidney disease and kidney transplant recipients, malabsorption, primary hyperparathyroidism, granulomatous disease, and those receiving treatments potentially inducing bone loss. Other patients in whom vitamin D concentration may be measured are those with symptoms compatible with a severe vitamin D defi ciency or excess persisting without explanation such as those with diffuse pain, or elderly individuals who fall, or those receiving treatments which modify vitamin D metabolism such as some anti-convulsants. Measurement of Vitamin D concentrations should also be part of any exploration of calcium/phosphorus metabolism which includes measurement of serum calcium, phosphate and PTH. [less ▲]

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See detailEffect of Transient Creep Strain Model on the Behavior of Concrete Columns Subjected to Heating and Cooling
Gernay, Thomas ULg

in Fire Technology (2012), 48(2), 313-329

In the numerical analysis of structures in fire, the material models that are used have important implications on the global behavior of the structure. In concrete, a particular phenomenon appears when ... [more ▼]

In the numerical analysis of structures in fire, the material models that are used have important implications on the global behavior of the structure. In concrete, a particular phenomenon appears when subjected to high temperatures: the transient creep strain. Models integrating explicitly a term for transient creep strain have been proposed in the literature but, in the current Eurocode 2 model, there is no explicit term for transient creep strain. This phenomenon is included in the Eurocode 2 model, but it is implicitly considered in the mechanical strain term. A series of experimental fire tests on axially restrained concrete columns subjected to heating and cooling has been recently performed at South China University of Technology and described by Wu et al. (Fire Technol 46:231–249). In the original paper, it was shown that using the implicit model of Eurocode 2, the behavior of the columns cannot be simulated properly, especially during the cooling phase. The objective of the present paper is to perform again the fire tests simulations using a new formulation of the Eurocode 2 model that contains an explicit term for transient creep. In the first part of the paper, the explicit formulation of the Eurocode 2 model is presented. In the second part, the fire tests are modeled with the software SAFIR using, on the one hand, the implicit Eurocode model and, on the other hand, the new explicit model. It is shown that the transient creep model has significant implications on the global behavior of structural concrete members, as the residual axial load sustained by the columns at the end of the fire can differ by up to 25% of the initial applied load depending on the transient creep strain model that is used for the calculation. The experimental behavior is better matched with the new explicit model than with the current Eurocode model. Particularly, the results given by the Eurocode model during the cooling phase are unconservative as the residual axial load is overestimated. Finally, it is explained why, on the basis of an example, in a performance-based approach, these results can have important implications on the global fire resistance of a structure. [less ▲]

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See detailL'économie sociale et solidaire
Huybrechts, Benjamin ULg

in Blanchet, Vivien; Carimentrand, Aurélie (Eds.) Dictionnaire du commerce équitable (2012)

Définit l'économie sociale et solidaire et positionne le commerce équitable par rapport à cette notion

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See detailLa dissuasion nucléaire du futur
Dumoulin, André ULg

in Défense et sécurité internationale hors série (2012), 23(23),

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See detailAn adaptive thermal comfort model for hot humid South-East Asia
Nguyen, Anh Tuan ULg; Singh, Manoj Kumar ULg; Reiter, Sigrid ULg

in Building & Environment (2012), 56

The present paper presents a full procedure to develop an adaptive comfort model for South-East Asia. Meta-analysis on large number of observations from field surveys which were conducted in this region ... [more ▼]

The present paper presents a full procedure to develop an adaptive comfort model for South-East Asia. Meta-analysis on large number of observations from field surveys which were conducted in this region was employed. Standardization and bias control of the database were fully reported. Statistical tests of significance and weighted regression method applied in the analyses strengthened the reliability of the findings. This paper found a great influence of ‘Griffiths constant’ on the establishment of adaptive comfort equation and proposed an appropriate value. The adaptive comfort model generated is applicable to naturally ventilated building under hot and humid conditions of South-East Asia. The mean neutral comfort temperature (operative temperature, effective temperature, standard effective temperature) in naturally ventilated and air-conditioned building was compared and the differences have been discussed. The similar neutral standard effective temperature in both naturally ventilated and air-conditioned building proposes a new idea to implement SET* into building simulation tools to assess thermal comfort without the attention of building classification. Through the analysis, the effectiveness of behavioral adaptive actions on occupant’s thermal perception has been argued. The extended PMV-PPD model for hot humid conditions was examined and its applicability was recommended. Other comfort related issues, the differences and similarities between various adaptive comfort models were also addressed. [less ▲]

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See detailOrganisation du commerce équitable
Huybrechts, Benjamin ULg

in Blanchet, Vivien; Carimentrand, Aurélie (Eds.) Dictionnaire du commerce équitable (2012)

Définition et discussion de la notion d'organisation du commerce équitable

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See detailLe statut du “logos” dans Être et temps.
Gauvry, Charlotte ULg

Conference (2012, April)

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See detailDroits de succession et de mutation par décès
Bourgeois, Marc ULg; Douny, Raphaël ULg; Gustin, Manuel ULg et al

in Chroniques notariales (2012)

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See detailExpression of specific pathways in the inflamed synovial membrane of osteoarthritis patient: Identification of new potential key intermediates
Lambert, Cécile ULg; Dubuc, Jean-Emile; Hennuy, Benoît ULg et al

in Osteoarthritis and Cartilage (2012, April), 20(Supplement 1), 56

Purpose: Synovitis is a key factor in osteoarthritis (OA) pathophysiology, contributing to both patient symptoms and disease progression. In this study, using an original methodology comparing normal ... [more ▼]

Purpose: Synovitis is a key factor in osteoarthritis (OA) pathophysiology, contributing to both patient symptoms and disease progression. In this study, using an original methodology comparing normal/reactive (N/R) and inflammatory (I) synovial membranes zones, we investigated the gene expression profiles of synovial cells from these areas and identified differentially regulated pathways. <br />Methods: Synovial cells (SC) were isolated from OA synovial specimens obtained from 12 patients undergoing knee replacement. The inflammatory status of the synovial membrane was characterized by the surgeon according to macroscopic criteria including the synovial vascularization, the villi formation and the hypertrophic aspect of the tissue. At the surgery time, the synovial membrane was dissected and biopsies from N/R and I areas cultured separately for a period of 7 days. Total RNA was extracted using the RNeasy Mini Kit. RNA purity and quality were evaluated using the Experion RNA StdSens Analysis kit (Bio-rad Laboratories). Gene expression profiling between N/R and I areas was performed using Illumina’s multi-sample format Human HT-12 BeadChip (Illumina Inc.). Differential analysis was performed with the BRB array tools software. Class Comparison test between N/R and I areas was based on paired t-test where N/R and I were paired for each patient. The biological relevance of up- and down-regulated genes was analyses with Ingenuity Pathways Analysis (Ingenuity® Systems). Western blot was performed to confirm certain intermediate expression. <br />Results: From among 47000 probes, 17500 were filtered out. Probes with a p-value below than 0.005 were chosen and classified as up- or down-regulated ones. By this way, 896 differentially expressed genes between N/R and I zones were identified. Among these, 576 genes were upregulated (I/NR > 1.5) and 320 downregulated (I/NR < 0.75). With Ingenuity Pathways Analysis, a significant number of the top ranking differentially expressed genes were identified as inflammatory, Wnt and angiogenic pathways. Interleukin (IL)-6 and -8, chemokines (CXCL1, CXCL2, CXCL5, CXCL6, CXCL16) and arachidonate 5-lipoxygenase (ALOX5) were identified as the most upregulated in I zones in the inflammatory pathway. Interestingly, the alarmin S100A9 was found strongly upregulated in this pathway. Wnt5A and LRP (Low density lipoprotein receptor-related protein) 5 were upregulated whereas FZD (Frizzled homolog) 2 and DKK (dickkopf homolog) 3 were downregulated in the Wnt signaling pathway. Finally, stanniocalcin (STC)-1, an intermediate in angiogenesis was identified as the most upregulated gene in I zones compared to N/R zones. This difference of expression was confirmed at the protein level. <br />Conclusions: Using a unique culture system, this study is the first to identify different expression pattern between two areas of synovial membrane from the same OA patient. These differences concern several key pathways involved in OA pathogenesis, i.e. inflammation, Wnt and angiogenesis. This analysis also provided interesting information regarding new potent intermediates as S100A9 and STC-1. They could be potential targets for chondroitin sulfate, one of the most used molecules in the management of OA. New experiments are being perfomed at the moment to elucidate the potential effect of this molecule on these specific differentially expressed genes in the same culture system. [less ▲]

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See detailDynamiques écosystémiques co-évolutives: proposition de typologie fonctionnelle des milieux
Hendrickx, Sébastien ULg; Van Der Kaa, Claire ULg; Dopagne, Claude ULg et al

in Notes de recherche - Conférence Permanente du Développement Territorial Région Wallonne (2012), 34

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See detailEl papel de los academicos en la sociedad del conocimiento
Jacquemain, Marc ULg

in Casas Guerrero, Rosalba; Carton de Grammont, Hubert (Eds.) Democracia, conocimiento y cultura (2012)

Los academicos en la sociedad del concocimiento tienen a la vez un papel de expertos y de ciudadanos. Su funcion en la sociedad del conocimiento supone que sus cualficaciones como expertos vengan en apoyo ... [more ▼]

Los academicos en la sociedad del concocimiento tienen a la vez un papel de expertos y de ciudadanos. Su funcion en la sociedad del conocimiento supone que sus cualficaciones como expertos vengan en apoyo al funcionamiento democratico de la sociedad lo que les impide actuar sencillamente como profesionales sinon tambien como actores democraticos. [less ▲]

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See detailToward a Risk Based Simulation for the Erection of an Offshore Windmill Park
Caprace, Jean-David ULg; Petcu, Cristian ULg; Velarde, Marco et al

in Proceeding of the 11th International Conference on Computer Applications and Information Technology in the Maritime Industries (2012, April)

Nowadays, EU shipyards that are facing difficulties due to the global crisis are often trying to diversify their activities. Some of them have already turned to the production of offshore windmill ... [more ▼]

Nowadays, EU shipyards that are facing difficulties due to the global crisis are often trying to diversify their activities. Some of them have already turned to the production of offshore windmill components. The installation and operation of offshore windmills are much more complex than onshore due to the distance and the depth of the water column. This creates problems specific to the production, installation and maintenance of offshore wind turbines. A tool for sequencing and installation simulation has been developed to assess the risks associated to the assembly of wind turbines parks via simulations of the different phases of construction considering various random phenomena such as weather conditions and uncertainties on production time. [less ▲]

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