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See detailMacroH2A1 regulates the balance between self-renewal and differentiation commitment in embryonic and adult stem cells.
Creppe, Catherine ULg; Janich, Peggy; Cantarino, Neus et al

in Molecular and cellular biology (2012), 32(8), 1442-52

One of the most striking epigenetic alterations that occurs at the level of the nucleosome is the complete exchange of the canonical H2A histones for the macroH2A variant. Here, we provide insight into ... [more ▼]

One of the most striking epigenetic alterations that occurs at the level of the nucleosome is the complete exchange of the canonical H2A histones for the macroH2A variant. Here, we provide insight into the poorly recognized function of macroH2A in transcriptional activation and demonstrate its relevance in embryonic and adult stem cells. Knockdown of macroH2A1 in mouse embryonic stem (mES) cells limited their capacity to differentiate but not their self-renewal. The loss of macroH2A1 interfered with the proper activation of differentiation genes, most of which are direct target genes of macroH2A. Additionally, macroH2A1-deficient mES cells displayed incomplete inactivation of pluripotency genes and formed defective embryoid bodies. In vivo, macroH2A1-deficient teratomas contained a massive expansion of malignant, undifferentiated carcinoma tissue. In the heterogeneous culture of primary human keratinocytes, macroH2A1 levels negatively correlated with the self-renewal capacity of the pluripotent compartment. Together these results establish macroH2A1 as a critical chromatin component that regulates the delicate balance between self-renewal and differentiation of embryonic and adult stem cells. [less ▲]

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See detailDynamique forestière et enrichissements forestiers. Site de Mbang. Rapport n° 8.
Doucet, Jean-Louis ULg; Amandé, Jean; Bracke, Charles et al

Report (2012)

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See detailBase de données sols de REQUASUD - 3ème synthèse
Genot, Valérie ULg; Renneson, Malorie ULg; Colinet, Gilles ULg et al

Book published by ASBL REQUASUD - D/2012/8689/1 (2012)

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See detailETAPE - Rapport d’évaluation des résultats
Vanmeerbeek, Marc ULg; Bednarek, Stéphanie; Lachaussée, Sophie et al

Report (2012)

Contexte et objectifs ETAPE est un programme d’intervention précoce à domicile au bénéfice de familles à risque de négligence parentale. Le programme prend en charge des enfants de 0 à 30 mois, ainsi que ... [more ▼]

Contexte et objectifs ETAPE est un programme d’intervention précoce à domicile au bénéfice de familles à risque de négligence parentale. Le programme prend en charge des enfants de 0 à 30 mois, ainsi que leurs parents, au rythme d’une à deux visites à domicile par semaine. L’intervention consiste en des massages du bébé, des jeux psychomoteurs. Un temps important est en outre consacré à l’accompagnement et à la guidance du rôle parental. L’originalité du projet est qu’il est centré sur le développement psychomoteur et affectif du bébé en lien avec son ou ses parents. L’étude cherche à mesurer l’efficacité du programme en termes de développement psychomoteur de l’enfant, de qualité d’attachement au sein de la dyade parent-enfant et de compétences éducatives des parents. Méthodologie Les aptitudes psychomotrices de l’enfant ont été mesurées au moyen du test de Brunet et Lézine modifié, au début, en milieu et en fin d’intervention. Le caractère sécure ou non de l’attachement a été mesuré chez le caregiver par Q-Sort en début et en fin d’intervention. Les compétences parentales ont été évaluées tous les six mois durant l’intervention au moyen d’un questionnaire développé par l’équipe de recherche en 2008 (MASPIN) et complété par les intervenants sur base de leurs observations. Résultats Douze enfants ont été étudiés. Les trois quarts ont été pris en charge avant 1 an ; la durée moyenne d’intervention est de 11,3 mois. En moyenne, les enfants gagnent nettement en score de développement moteur global, gagnent un peu en socialisation, sont stables en développement moteur fin. La plupart régressent au score de langage, ce qui influence négativement le score global de développement. Deux enfants sur douze sont sécures au début et à la fin de l’intervention (mais ce ne sont pas les mêmes). Aucun ne termine l’intervention significativement insécurisé, mais la relation dans la dyade n’est en général pas optimale. Les résultats de MASPIN permettent d’étoffer les autres résultats obtenus et de mieux comprendre l’évolution au cas par cas. Discussion Les résultats, mesurés par les tests de Brunet-Lézine et le Q-Sort semblent modestes dans certains domaines, mais doivent être analysés à la lumière des conditions d’intervention. MASPIN a donné une vue beaucoup plus précise de la réalité et de son évolution. Ce questionnaire a aussi permis de monitorer l’intervention. Toutefois, la finesse des observations et l’aspect subjectif de la cotation empêchent une analyse globale des résultats ; la fidélité intercotateur doit encore être validée. MASPIN permet en outre de donner des repères pour le dialogue avec d’autres professionnels impliqués dans le suivi des situations, et fournit un canevas qui facilite la discussion avec les familles sur l’exercice de la parentalité et les objectifs d’intervention. L’analyse des résultats permet de prendre conscience que certaines compétences (par ex., le langage) méritent d’être mieux soutenues et stimulées par les intervenants de terrain.) Des collaborations extérieures devront être développées (par ex : psychologue, aide sociale). L’investissement requis de la part des intervenants est important. Le risque de découragement est grand ; ils doivent être soutenus et supervisés de façon efficace dans ce travail. L’instauration d’un vrai esprit d’équipe est indispensable Conclusion Le rendement de ce programme, destiné à un public particulièrement difficile, est intéressant mais variable selon les situations prises en charge, que ce soit en termes de développement psychomoteur ou d’attachement à la figure parentale. L’outil MASPIN se révèle précieux dans de multiples aspects de la prise en charge, depuis le dialogue avec les professionnels qui identifient la situation, jusqu’au monitorage des objectifs au fil de l’intervention, en passant par la construction des objectifs d’intervention avec les parents. [less ▲]

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See detailBriefe an Casanova
Roggendorf, Cécile de; Viehöver, Vera ULg

E-print/Working paper (2012)

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See detailMapping error due to image geometric correction.
Hallot, Eric ULg; Cornet, Yves ULg; Hallot, Pierre ULg

Poster (2012, April)

Nowadays, image processing and GIS tools are more accessible and available to all. Most of diachronical or historical studies use the image geometric correction with several documents like old maps, plans ... [more ▼]

Nowadays, image processing and GIS tools are more accessible and available to all. Most of diachronical or historical studies use the image geometric correction with several documents like old maps, plans or aerial photographs. They are usually based on low-order polynomial equation to perfom these kinds of simplistic uses. Most of commercial softwares provide us a total or by ground control points RMSE but they don’t offer a overview of the spatial error distribution. More this does not guarantee that its significance for the other points of the image. Do not consider these errors can lead to erroneous observations and misinterpretations like historical moving streams or bank erosion rate. Using a least square adjustment (LSA), allow to recalculate the transformation equation from the pairs of control points coordinates. Assuming that residuals are spatially auto-correlated, we can build error vectors whose direction and magnitude symbolize the error at each point of the image. By another way, LSA manage the precision during transformation process by using a stochastic model in addition of the mathematical model during the transformation. This gives us variance on parameters of the transformation. Knowing the precision of all elements and variance/covariance matrix on transformation parameters, we apply variance propagation on the model. As an output, we obtain confidence ellipses on each transformed points, thus a spatial distribution of error for the entire image. Moreover, this leads us to determine statistically if observed movement are significant or not. The represent error is a complex problem that cannot be solved with a quick fix. In this work, we present an interesting example of using well-known topographic methods to solve image processing problems. [less ▲]

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See detailLong-term magnetic field monitoring of the Sun-like star \xi Bootis A
Morgenthaler, A.; Petit, P.; Saar, S. et al

in Astronomy and Astrophysics (2012), 540

Aims: We aim to investigate the long-term temporal evolution of the magnetic field of the solar-type star ξ Bootis A, both from direct magnetic field measurements and from the simultaneous estimate of ... [more ▼]

Aims: We aim to investigate the long-term temporal evolution of the magnetic field of the solar-type star ξ Bootis A, both from direct magnetic field measurements and from the simultaneous estimate of indirect activity indicators. Methods: We obtained seven epochs of high-resolution, circularly-polarized spectra from the NARVAL spectropolarimeter between 2007 and 2011, for a total of 76 spectra. Using approximately 6100 photospheric spectral lines covering the visible domain, we employed a cross-correlation procedure to compute a mean polarized line profile from each spectrum. The large-scale photospheric magnetic field of the star was then modelled by means of Zeeman-Doppler Imaging, allowing us to follow the year-to-year evolution of the reconstructed magnetic topology. Simultaneously, we monitored the width of several magnetically sensitive spectral lines, the radial velocity, the line asymmetry of intensity line profiles, and the chromospheric emission in the cores of the Ca II H and Hα lines. Results: During the highest observed activity states, in 2007 and 2011, the large-scale field of ξ Bootis A is almost completely axisymmetric and is dominated by its toroidal component. The toroidal component persists with a constant polarity, containing a significant fraction of the magnetic energy of the large-scale surface field through all observing epochs. The magnetic topologies reconstructed for these activity maxima are very similar, suggesting a form of short cyclicity in the large-scale field distribution. The mean unsigned large-scale magnetic flux derived from the magnetic maps varies by a factor of about 2 between the lowest and highest observed magnetic states. The chromospheric flux is less affected and varies by a factor of 1.2. Correlated temporal evolution, due to both rotational modulation and seasonal variability, is observed between the Ca II emission, the Hα emission and the width of magnetically sensitive lines. The rotational dependence of polarimetric magnetic measurements displays a weak correlation with other activity proxies, presumably due to the different spatial scales and centre-to-limb darkening associated with polarimetric signatures, as compared to non-polarized activity indicators. Better agreement is observed on the longer term. When measurable, the differential rotation reveals a strong latitudinal shear in excess of 0.2 rad d-1. [less ▲]

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See detailNatural Killer cells - role in local tumor growth and metastasis
Langers, Inge ULg; Renoux, Virginie ULg; Thiry, Marc ULg et al

in Biologics: Targets and Therapy (2012)

Historically, the name of Natural Killer (NK) cells came from their natural ability to kill tumor cells in vitro. From the seventies to date, accumulating data highlighted the importance of NK cells in ... [more ▼]

Historically, the name of Natural Killer (NK) cells came from their natural ability to kill tumor cells in vitro. From the seventies to date, accumulating data highlighted the importance of NK cells in host immune response against cancer and in therapy-induced anti-tumor response. The recognition and the lysis of tumor cells by NK cells are regulated by a complex balance of inhibitory and activating signals. This review summarizes NK cell mechanisms to kill cancer cells, their role in host immune responses against tumor growth or metastasis and their implications in anti-tumor immunotherapies via cytokines, antibodies or in combination with other therapies. The regulatory role of NK cells in autoimmunity is also discussed. [less ▲]

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See detailPrésentation des résultats de la recherche SAFE
Reiter, Sigrid ULg; Marique, Anne-Françoise ULg; de Meester, Tatiana

Conference given outside the academic context (2012)

Présentation des résultats de la recherche SAFE et d'un outil interactif permettant à différentes catégories d'utilisateurs d'estimer les consommations d'énergie relatives à leur logement et à leur ... [more ▼]

Présentation des résultats de la recherche SAFE et d'un outil interactif permettant à différentes catégories d'utilisateurs d'estimer les consommations d'énergie relatives à leur logement et à leur déplacements, à les comparer et à trouver des pistes concrètes d'amélioration. [less ▲]

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See detailPast into Future: Cyprus' Undivided Literature - AydIn Mehmet Ali and Stephanos Stephanides
Pagnoulle, Christine ULg

in Kunapipi : Journal of Postcolonial Writing (2012), 33(1-2), 202-214

The present article examines poems by Stephanides and short stories by Mehmet Ali (of Greek and Turkish origins respectively, as their names indicate), bringing out a common sensibility to loss and ... [more ▼]

The present article examines poems by Stephanides and short stories by Mehmet Ali (of Greek and Turkish origins respectively, as their names indicate), bringing out a common sensibility to loss and yearning for reconciliation. In keeping with what is brought out throughout this remarkable double issue edited by Anne Collett it stresses the underlying unity in hte island's literature. [less ▲]

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See detailAnticipatory Modeling and Simulation for Inter Regional Security
Dubois, Daniel ULg; Asproth, Viveca; Stig C, Holmberg et al

Conference (2012, April)

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See detailA fully nonlinear finite element model for orthodontic tooth movement prediction
Mengoni, Marlène ULg; D'Otreppe, Vinciane ULg; Ponthot, Jean-Philippe ULg

in Proceedings of the 10th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering. (2012, April)

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See detailInorganic carbon dynamics in coastal arctic sea ice and related air-ice CO2 exchanges
Geilfus, Nicolas-Xavier ULg; Tison, J.-L.; Carnat, G. et al

Poster (2012, April)

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See detailNon invasive sleep monitoring
Deliège, Benjamin; Coppieters't Wallant, Dorothe ULg

Conference (2012, April)

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See detailMotor fatigue measurement by distance-induced slow down of walking speed in multiple sclerosis
PHAN BA, Remy ULg; CALAY, Philippe ULg; GRODENT, Patrick ULg et al

in PLoS ONE (2012), 7(4), 34744

Background: Motor fatigue and ambulation impairment are prominent clinical features of people with multiple sclerosis (pMS). We hypothesized that a multimodal and comparative assessment of walking speed ... [more ▼]

Background: Motor fatigue and ambulation impairment are prominent clinical features of people with multiple sclerosis (pMS). We hypothesized that a multimodal and comparative assessment of walking speed on short and long distance would allow a better delineation and quantification of gait fatigability in pMS. Objectives: To compare 4 walking paradigms: the timed 25-foot walk (T25FW), a corrected version of the T25FW with dynamic start (T25FW+), the timed 100-meter walk (T100MW) and the timed 500-meter walk (T500MW). Methods: Thirty controls and 81 pMS performed the 4 walking tests in a single study visit. Results: The 4 walking tests were performed with a slower WS in pMS compared to controls even in subgroups with minimal disability. The finishing speed of the last 100-meter of the T500MW was the slowest measurable WS whereas the T25FW+ provided the fastest measurable WS. The ratio between such slowest and fastest WS (Deceleration Index, DI) was significantly lower only in pMS with EDSS 4.0-6.0, a pyramidal or cerebellar functional system score reaching 3 or a maximum reported walking distance !4000m. Conclusion: The motor fatigue which triggers gait deceleration over a sustained effort in pMS can be measured by the WS ratio between performances on a very short distance and the finishing pace on a longer more demanding task. The absolute walking speed is abnormal early in MS whatever the distance of effort when patients are unaware of ambulation impairment. In contrast, the DI-measured ambulation fatigability appears to take place later in the disease course. [less ▲]

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See detailPoroelastic Center of Dilation Revisited
Huynen, Alexandre ULg

Master of advanced studies dissertation (2012)

In both elasticity and poroelasticity, the nucleus of strain is usually used to refer to a singular solution such as the point force, the force dipole, the centers of rotation and dilation, etc. These ... [more ▼]

In both elasticity and poroelasticity, the nucleus of strain is usually used to refer to a singular solution such as the point force, the force dipole, the centers of rotation and dilation, etc. These fundamentals solutions constitute the building blocks for various problems of practical importance and are, therefore, relatively well understood. However, a comparison of the original elastic solution for the center of dilation with the classic Lamé solution reveals an unexpected dependence of the center of dilation solution on the Poisson’s ratio. This inconsistency is investigated by means of two alternative representations of the singularity and leads to the identification of a compressed zone inside the singularity. The poroelastic equivalent to this nucleus of strain is shown to be the superposition of the elastic one with drained material parameters and an instantaneous point fluid source associated with a finite volume of fluid that is expelled from the compressed region inside the singularity and is injected in the porous medium. [less ▲]

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See detail"Les testaments"
Moreau, Pierre ULg

in Chroniques notariales, vol. 55 (2012)

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See detailRèglement 2201/2003 en matière de dissolution du mariage et de responsabilité parentale : synthèse de jurisprudence
Wautelet, Patrick ULg

in Van Drooghenbroeck, Jean-François (Ed.) Droit judiciaire européen et international (2012)

This paper presents an overview of the case law of the ECJ in relation to Regulation 2201/2003. The focus is on cases decided by the ECJ and by French and Belgian courts, with a few reference made to ... [more ▼]

This paper presents an overview of the case law of the ECJ in relation to Regulation 2201/2003. The focus is on cases decided by the ECJ and by French and Belgian courts, with a few reference made to court practice in England. Cases are presented and discussed in relation to the various provisions of the Regulation to which they relate. For each case, an abstract is included, followed by (critical) comments. This overview appeared in a book presenting the main European regulations dealing with European procedural law (jurisdiction of courts, recognition and enforcement of foreign judgments). The book is part of a series edited by Prof. Georges de Leval (University of Liège), which collects court practice in relation to procedural law. [less ▲]

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See detailHumidity 3D field comparisons between GNSS tomography, IASI satellite observations and ALARO model
Brenot, Hugues; Champollion, Cedric; Deckmyn, Alex et al

in Geophysical Research Abstracts (2012, April), 14

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