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See detailDynamic interaction between lymphoid tyrosine phosphatase and C-terminal Src kinase controls T cell activation
Tautz, Lutz; Vang, Torkel; Liu, Wallace et al

in FASEB Journal (2012, April), 26

Lymphoid tyrosine phosphatase (LYP) and C-terminal Src kinase (CSK) are negative regulators of signaling mediated through the T cell antigen receptor (TCR) and are thought to act in a cooperative manner ... [more ▼]

Lymphoid tyrosine phosphatase (LYP) and C-terminal Src kinase (CSK) are negative regulators of signaling mediated through the T cell antigen receptor (TCR) and are thought to act in a cooperative manner when forming a complex. Here, we show that dissociation of the LYP/CSK complex is necessary for recruitment of LYP to lipid rafts, where it down-modulates TCR-mediated signaling. Our findings may also explain the reduced TCR signaling associated with a single nucleotide polymorphism, which confers increased risk for autoimmunity and results in the expression of a LYP allele that can no longer bind CSK. Development of a potent and selective chemical probe of LYP allowed us to confirm that the observed down-modulation of TCR-induced signaling was due to the LYP catalytic activity. Our compound also represents a starting point for the development of a LYP-based treatment of autoimmunity. [less ▲]

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See detailhe influence of transformational leadership on commitment: New underlying processes
Marique, Géraldine; Stinglhamber, Florence; Hanin, Dorothée et al

Poster (2012, April)

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See detailQuerelles d’écrivains (XIXe-XXIe siècles) : de la dispute à la polémique, dans COnTEXTES, revue de sociologie de la littérature
Groupe de contact FNRS Contextes en sociologie de la littérature; Dozo, Björn-Olav ULg

Book published by COnTEXTES (2012)

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See detailEffect of Transient Creep Strain Model on the Behavior of Concrete Columns Subjected to Heating and Cooling
Gernay, Thomas ULg

in Fire Technology (2012), 48(2), 313-329

In the numerical analysis of structures in fire, the material models that are used have important implications on the global behavior of the structure. In concrete, a particular phenomenon appears when ... [more ▼]

In the numerical analysis of structures in fire, the material models that are used have important implications on the global behavior of the structure. In concrete, a particular phenomenon appears when subjected to high temperatures: the transient creep strain. Models integrating explicitly a term for transient creep strain have been proposed in the literature but, in the current Eurocode 2 model, there is no explicit term for transient creep strain. This phenomenon is included in the Eurocode 2 model, but it is implicitly considered in the mechanical strain term. A series of experimental fire tests on axially restrained concrete columns subjected to heating and cooling has been recently performed at South China University of Technology and described by Wu et al. (Fire Technol 46:231–249). In the original paper, it was shown that using the implicit model of Eurocode 2, the behavior of the columns cannot be simulated properly, especially during the cooling phase. The objective of the present paper is to perform again the fire tests simulations using a new formulation of the Eurocode 2 model that contains an explicit term for transient creep. In the first part of the paper, the explicit formulation of the Eurocode 2 model is presented. In the second part, the fire tests are modeled with the software SAFIR using, on the one hand, the implicit Eurocode model and, on the other hand, the new explicit model. It is shown that the transient creep model has significant implications on the global behavior of structural concrete members, as the residual axial load sustained by the columns at the end of the fire can differ by up to 25% of the initial applied load depending on the transient creep strain model that is used for the calculation. The experimental behavior is better matched with the new explicit model than with the current Eurocode model. Particularly, the results given by the Eurocode model during the cooling phase are unconservative as the residual axial load is overestimated. Finally, it is explained why, on the basis of an example, in a performance-based approach, these results can have important implications on the global fire resistance of a structure. [less ▲]

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See detailIntegrated control and structural analysis of DFIG wind turbines using a monolithic approach
Chen, Qiongzhong ULg; D'Ambrosio, Flavio; Defourny, Michel et al

in Proceedings of the European Wind Energy Conference and Exhibition 2012 (EWEA 2012) (2012, April)

Design of wind turbines requires the coupled analysis among the mechanical, control and aerodynamic subsystems. Different from previous research, which either uses a complicated mechanical model with a ... [more ▼]

Design of wind turbines requires the coupled analysis among the mechanical, control and aerodynamic subsystems. Different from previous research, which either uses a complicated mechanical model with a simple control system model, or vice versa, this paper studies the coupling of subsystems’ dynamics using a high-fidelity aeroelastic model of wind turbine and a detailed analytical model of control generating systems. A monolithic time integration approach is applied so that better numerical accuracy and stability are achieved. Control strategies on power optimization are discussed taking into account the influence of structural flexibility. Simulation examples are given on both stable and turbulent wind situation. [less ▲]

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See detailUm conjunto apenas aparentemente heterogêneo de contribuições
Cupani, Alberto; Guivant, Julia; Delvenne, Pierre ULg

in Política & Sociedade (2012), 11(20), 11-21

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See detailL'astronomie dans le monde
Manfroid, Jean ULg

Article for general public (2012)

Collision dans le Dragon; Trou noir de masse intermédiaire;Zoom sur une galaxie lointaine; Les jours de Vénus s’allongent ?; Lumière cendrée; Anomalies magnétiques lunaires; Océan martien; Hercule par le ... [more ▼]

Collision dans le Dragon; Trou noir de masse intermédiaire;Zoom sur une galaxie lointaine; Les jours de Vénus s’allongent ?; Lumière cendrée; Anomalies magnétiques lunaires; Océan martien; Hercule par le VST [less ▲]

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See detailMeasuring the phase of the scattering amplitude with vortex beams
Ivanov, Igor ULg

in Physical Review. D : Particles and Fields (2012), 85(7), 07600110

We show that colliding vortex beams instead of (approximate) plane waves can lead to a direct measurement of how the overall phase of the plane wave scattering amplitude changes with the scattering angle ... [more ▼]

We show that colliding vortex beams instead of (approximate) plane waves can lead to a direct measurement of how the overall phase of the plane wave scattering amplitude changes with the scattering angle. Since vortex beams are coherent superpositions of plane waves with different momenta, their scattering amplitude receives contributions from plane wave amplitudes with distinct kinematics. These contributions interfere, leading to the measurement of their phase difference. Although interference exists for any generic wave packet collision, we show that using vortex beams dramatically enhances sensitivity to the phase in comparison with nonvortex beams. Since the overall phase is inaccessible in a plane wave collision, this measurement would be of great importance for a number of topics in hadronic physics, for example, meson production in the resonance region, physics of nucleon resonances, and small angle elastic hadron scattering. [less ▲]

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See detailHigher-Moment Risk Exposures in Hedge Funds
Lambert, Marie ULg; Hübner, Georges ULg; Papageorgiou, Nicolas

Conference (2012, April)

The paper singles out the key roles of US equity skewness and kurtosis in the determination of the market premia embedded in Hedge Fund returns. We propose a conditional higher-moment asset pricing model ... [more ▼]

The paper singles out the key roles of US equity skewness and kurtosis in the determination of the market premia embedded in Hedge Fund returns. We propose a conditional higher-moment asset pricing model with location, trading and higher-moment factors in order to describe the dynamics of the Equity Hedge (Market Neutral, Short Selling and Long/Short strategies), Event Driven, Relative Value, and Funds of Hedge Funds styles. The volatility, skewness and kurtosis implied in the US options markets are used by Hedge Fund managers as instruments to anticipate market movements. Managers should adjust their market exposure in response to variations in the implied higher moments. We show that higher-moment premia improve a conditional asset pricing model both in terms of explanatory power (R-squares and Schwarz criterion) and specification errors across all Hedge Fund styles. [less ▲]

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See detailHow does elicitor and antimicrobial fengycin interact with plasma membranes of sensitive cells ?
Nasir, Mehmet Nail ULg; Eeman, Marc; Lins, Laurence ULg et al

Conference (2012, April)

Fengycin is characterized by its strong antifungal and low hemolytic activities. It has also been recently demonstrated that it has plant elicitor properties and is also able to enhance the elicitors’ ... [more ▼]

Fengycin is characterized by its strong antifungal and low hemolytic activities. It has also been recently demonstrated that it has plant elicitor properties and is also able to enhance the elicitors’ activity of surfactin. The cell target of its biological activities is supposed to be plasma membrane. In spite of these interesting biological activities, fengycin has not been extensively investigated probably because of the difficulties related to its production. In a first time; we have characterized the interfacial properties of fengycin by tensiometry measurements and demonstrated that this surface activity was pH-dependent. In a second time; we have investigated the interactions of the lipopeptide with membrane lipids using model membranes such as Langmuir monolayers and multilammelar vesicles (MLVs). Our results indicate that the lipopeptide was able to penetrate into different lipid monolayers showing a preference for sterol-containing monolayers. In order to better understand the mechanism of the interactions of fengycin with membranes at the molecular level, MLVs with or without fengycin have been analyzed by spectroscopic techniques. We have shown that conformational changes of the lipopeptide occurred in the presence of lipids and they were more significant in the presence of sterol. Moreover, tyrosine residues of the lipopeptide seem to play an important role in these interactions. In conclusion, we have determined that the surface-active behavior as well as the conformation of fengycin depends on its environment. We have also showed that the lipopeptide does not interact with all class of lipids in the same way and presents a preference for sterols. The presence of key groups within peptide cycle has also been supposed for the biological activities of the lipopeptide. [less ▲]

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See detailThe size and book-to-market effects revisited
Lambert, Marie ULg; Hübner, Georges ULg

E-print/Working paper (2012)

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See detailPhysiologie, pharmacologie et modélisation de canaux potassiques : zoom sur les canaux SK
Dilly, Sébastien ULg; Poncin, Sylvie; Lamy, Cédric et al

in Medecine Sciences : M/S (2012), 28

Various types of ion channels are involved in the control of neuronal activity. Among them, SK channels represent an interesting therapeutic target. Indeed, they underlie medium duration ... [more ▼]

Various types of ion channels are involved in the control of neuronal activity. Among them, SK channels represent an interesting therapeutic target. Indeed, they underlie medium duration afterhyperpolarizations in many types of neurons, thus inhibiting cell excitability. A thorough knowledge of the physiology of these channels and the discovery of non-peptidic selective modulators able to pass the blood-brain barrier are essential in view of developing future drugs for brain diseases such as those related to a dysfunction of dopaminergic and serotonergic systems. [less ▲]

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See detailLa dissuasion nucléaire du futur
Dumoulin, André ULg

in Défense et sécurité internationale hors série (2012), 23(23),

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See detailRéponses du Martin-pêcheur huppé Alcedo cristata à la perturbation de ses sites de nidification
Kisasa Kafutshi, Robert ULg

in Malimbus (2012), 34(28-38),

From 2004 to 2009, two colonies of Malachite Kingfisher were monitored by ringing the nestlings and adults, counting eggs and observing parental activity at the nests. Results show that 10 % of nests were ... [more ▼]

From 2004 to 2009, two colonies of Malachite Kingfisher were monitored by ringing the nestlings and adults, counting eggs and observing parental activity at the nests. Results show that 10 % of nests were destroyed by people in the Symphonies site as against 78 % in the Monastery site. Consequently, the number of nests available for breeding is lower at Monastery than at Symphonies. The number of fledged chicks per nest at Symphonies was twice that at the Monastery. Site fidelity is higher for the adults in the Symphonies site (26 %) than at the Monastery (11 %). This suggests that the Monastery site is less favourable to the survival of the Malachite Kingfisher than the Symphonies site. The best strategy to protect this species seems to be the maintenance of a good number of nesting sites. [less ▲]

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See detailLes polémiques autour de la littérature jeunesse, ou la quête sans cesse rejouée de la légitimité
Barnabé, Fanny ULg

in COnTEXTES : Revue de Sociologie de la Littérature (2012), (10),

Cet article analyse les enjeux dissimulés derrière une polémique qui a débuté suite à un article de François Busnel, publié le 24 novembre 2010 dans l’Express-Lire, dans lequel ce dernier dénigre la ... [more ▼]

Cet article analyse les enjeux dissimulés derrière une polémique qui a débuté suite à un article de François Busnel, publié le 24 novembre 2010 dans l’Express-Lire, dans lequel ce dernier dénigre la littérature jeunesse et l’accuse de n’être qu’un "coup marketing". Cette publication a déclenché de nombreuses réactions chez les représentants de ce secteur. L'analyse proposée ici tâche de rendre compte, en confrontant les deux types de prises de parole, de l’impact que peut avoir l’objet d'une polémique (la littérature jeunesse, dans ce cas-ci) sur le déroulement de celle-ci. [less ▲]

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See detailL'économie sociale et solidaire
Huybrechts, Benjamin ULg

in Blanchet, Vivien; Carimentrand, Aurélie (Eds.) Dictionnaire du commerce équitable (2012)

Définit l'économie sociale et solidaire et positionne le commerce équitable par rapport à cette notion

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See detailOrganisation du commerce équitable
Huybrechts, Benjamin ULg

in Blanchet, Vivien; Carimentrand, Aurélie (Eds.) Dictionnaire du commerce équitable (2012)

Définition et discussion de la notion d'organisation du commerce équitable

Detailed reference viewed: 187 (11 ULg)