References of "2012"
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See detailContribution of high mass resolution and accuracy of FTMS to molecular imaging
Debois, Delphine ULg; Calligaris, David ULg; Cimino, Jonathan ULg et al

Conference (2012, April 04)

Since its first implementation in 1997, MALDI Mass Spectrometry Imaging (MALDI MSI) has become an important tool in the proteomic arsenal, especially for biomarker hunting. First dedicated to high ... [more ▼]

Since its first implementation in 1997, MALDI Mass Spectrometry Imaging (MALDI MSI) has become an important tool in the proteomic arsenal, especially for biomarker hunting. First dedicated to high molecular weight, MALDI MSI is more and more used to map the distribution of small molecules too (lipids, drugs and metabolites,…). Last developments tend to improve the sample treatments to obtain the best spatial resolution as possible. From this perspective, great efforts have been made on the MALDI matrix deposition methods. Now, one of the remaining challenges for MALDI-MSI users consists of identification of detected molecules. For high molecular weight, methods inspired by classical proteomics techniques, are regularly used. Bottom-Up (PMF obtained after in situ trypsin digestion) and Top-Down (in situ In-Source Decay) approaches have been used directly from a tissue slice, leading to the identification of some of the most abundant proteins present at the surface of the tissue. When small molecules are analyzed, the identification is more straightforward. Indeed, tandem mass spectrometry can easily be used, leading to the fragmentation of the detected compounds which allows their unambiguous identification. This identification is even more reliable when high resolution exact mass measurements can be performed. In this talk, I will present how in our lab, we profit of the exceptional features of FT-ICR mass spectrometry for imaging and especially for identification purposes. The first example will deal with the benefit of high mass accuracy and high mass resolution for ISD-based protein identification. The mass accuracy and high mass resolution coupled with the use of a “cleaning” software allow unequivocal assignment of ISD fragments of proteins, in the low mass range (m/z between 300 and 900), whether from pure solutions or from tissue slices. The next examples will deal with the imaging of small molecules. The identification of drugs and their metabolites is facilitated with high mass accuracy. In our lab, we work on the localization of methadone and its first metabolite, EDDP in necrophagous fly larvae. In the mass range of these compounds (278-310 m/z), many matrix ion peaks are detected and the unique features of FT-ICR allows for unambiguous identification thanks to exact mass measurements. We also use MALDI Imaging to map the messenger molecules between plant roots and beneficial bacteria. The comparison of spectra recorded with a TOF/TOF instrument and with a FT-ICR demonstrates that high resolution allows for detecting molecules which could have been missed otherwise. It also allows to distinguish unknown compounds from alkali adducts of known molecules. [less ▲]

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See detailL’action publique de lutte contre le travail des enfants au Burkina Faso : politiques, acteurs, dynamique d’actions et controverses
Wouango, Joséphine ULg

Doctoral thesis (2012)

La thèse analyse les politiques et les interventions en matière de protection de l'enfance au Burkina Faso. Les enseignements de cette recherche concernent sa dimension empirique d'une part et son objet ... [more ▼]

La thèse analyse les politiques et les interventions en matière de protection de l'enfance au Burkina Faso. Les enseignements de cette recherche concernent sa dimension empirique d'une part et son objet spécifique d'autre part. Cet objet n'est pas le travail des enfants comme tel, mais la construction d'une politique publique dans un pays qui reste massivement rural et largement dépendant de l'aide internationale. [less ▲]

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See detailÉduCoP case study: the Community of Practice of learners in Educational Sciences at the University of Liège.
Denis, Brigitte ULg; Bomgart, Marie-Laure ULg

in Hodgson; Jones, C; de Laat, J (Eds.) et al Proceedings of the Eighth International Conference on Networked Learning 2012 (2012, April 03)

The concept of Community of Practice (CoP) takes nowadays a great part in the formal or informal learning domain. In addition, computerised tools are often used to sustain the activities of these ... [more ▼]

The concept of Community of Practice (CoP) takes nowadays a great part in the formal or informal learning domain. In addition, computerised tools are often used to sustain the activities of these communities (Wenger, White & Smith, 2009). The ÉduCoP case study deals with the creation and the animation process of a CoP that was launched in 2010 at the University of Liège. Initiated by a master student in educational sciences, it aims at developing and making durable a community of practice composed of learners in this field and supported by Information and Communication Technologies. This paper presents several actions undertaken to develop this CoP: the analysis of the potential members' needs, stakes and motivations of students to enrol in this project; the choice of useful and usable technological tools to provide them (here, the eGroupWare platform) and the training sessions linked to its efficient uses; the activities conducted to develop the CoP's members identity and to lead them to debate about common topics, to produce and share resources. The CoP's evolution was observed through qualitative and quantitative data collection processes (e.g. interviews about the members' implication and roles, support from animator, obstacles, feeling to belong to a CoP, analysis of the topics presented in the posted documents and messages, uses of the technological tools, frequency of connection...). The results are discussed here and perspectives are evoked for this CoP. If the actions undertaken show encouraging results, neverthless obstacles to the creation and the evolution of such a CoP have been identified (e.g. lack of technological culture among some members, reluctance to share personal productions). Some perspectives are considered to overcome these problems. Since October 2011, this initiative has been recognised at the institutional level: the university is interested in lessons learned in order to implement CoP into other faculties that would be willing to start networking and create communities of learners or of practice. [less ▲]

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See detailLa querelle territoriale entre Samos et Priène : réponse à une invitation au débat
Famerie, Etienne ULg

Scientific conference (2012, April 03)

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See detailDimension Reduction and Measure Transformation in Stochastic Multiphysics Modeling
Arnst, Maarten ULg; Ghanem, Roger; Phipps, Eric et al

Conference (2012, April 02)

We present a computational framework based on stochastic expansion methods for the efficient propagation of uncertainties through multiphysics models. The framework leverages an adaptation of the Karhunen ... [more ▼]

We present a computational framework based on stochastic expansion methods for the efficient propagation of uncertainties through multiphysics models. The framework leverages an adaptation of the Karhunen-Loeve decomposition to extract a low-dimensional representation of information passed from component to component in a stochastic coupled model. After a measure transformation, the reduced-dimensional interface thus created enables a more efficient solution in a reduced-dimensional space. We demonstrate the proposed approach on an illustration problem from nuclear engineering [less ▲]

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See detailLes dysphasies : sémiologie et hypothèses explicatives
Maillart, Christelle ULg

Conference given outside the academic context (2012)

Detailed reference viewed: 149 (19 ULg)
See detailStochastic Dimension Reduction Techniques for Uncertainty Quantification of Multiphysics Systems
Phipps, Eric; Arnst, Maarten ULg; Constantine, Paul et al

Conference (2012, April 02)

Uncertainty quantification of multiphysics systems represents numerous mathematical and computational challenges. Indeed, uncertainties that arise in each physics in a fully coupled system must be ... [more ▼]

Uncertainty quantification of multiphysics systems represents numerous mathematical and computational challenges. Indeed, uncertainties that arise in each physics in a fully coupled system must be captured throughout the whole system, the so-called curse of dimensionality. We present techniques for mitigating the curse of dimensionality in network-coupled multiphysics systems by using the structure of the network to transform uncertainty representations as they pass between components. Examples from the simulation of nuclear power plants will be discussed. [less ▲]

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See detailInstitutional Change and Legislative Stability: Explicit and Contested Decision-Making in the EU Council (1995-2010)
Van Aken, Wim ULg

E-print/Working paper (2012)

In contrast to general expectations the growth of EU membership as well as European treaty reform has not had any significant impact on the Council’s overall legislative and roll call activity. On the ... [more ▼]

In contrast to general expectations the growth of EU membership as well as European treaty reform has not had any significant impact on the Council’s overall legislative and roll call activity. On the basis of a new dataset representing the total population of public roll calls and recorded votes in the Council this paper explains why the EU Council has been so successful in guaranteeing legislative and roll call stability between 1995 and 2010. The quantitative and qualitative analysis finds that frontloading legislation, changing voting behaviour, reinforcement of existing coalition patterns and the successful adjustment of newer Member States to the EU Council have contributed to the EU Council’s decision-making capacity during the observed 16 years. In explaining the apparent contradiction between institutional change and the Council’s legislative stability this paper contributes to our knowledge of the functioning, the decision-making processes and the geography of contestation in the EU Council. [less ▲]

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See detailNanotechnologies. Qu'est devenu le principe de précaution?
Thoreau, François ULg; Feltz, Bernard

Article for general public (2012)

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See detailSimuler la ressource forestière à l'échelle d'un massif : application de SIMMEM et GYMNOS
Ligot, Gauthier ULg; Vallet, Patrick; Perin, Jérôme ULg et al

Conference (2012, April 02)

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See detailQuels modes de gouvernance pour la PMI tunisienne? Les enseignements de la littérature
Ghorbel, Jihene ULg; Van Caillie, Didier ULg

Conference (2012, April 02)

Les Petites et Moyennes Entreprises (PME), et tout particulièrement les Petites et Moyennes Industries (PMI), constituent un des piliers de l’économie tunisienne. Néanmoins, malgré l’abondance des études ... [more ▼]

Les Petites et Moyennes Entreprises (PME), et tout particulièrement les Petites et Moyennes Industries (PMI), constituent un des piliers de l’économie tunisienne. Néanmoins, malgré l’abondance des études consacrées aux PME dans le monde, rares sont les recherches scientifiques qui portent sur les spécificités des PME industrielles dans ce contexte géographique donné. Simultanément, face au phénomène de mondialisation croissante de l'économie et aux crises économiques et financières qui marquent la vie économique mondiale en cette première décennie du nouveau millénaire, un consensus émerge dans la littérature conduisant au constat que les PME et les PMI doivent impérativement renforcer et améliorer à la fois leurs systèmes de contrôle et de gouvernance si elles veulent jouer un rôle majeur dans leur tissu économique respectif et si elles souhaitent consolider leur crédibilité auprès de l'ensemble de leurs partenaires externes (banquiers, Pouvoirs Publics, organes de contrôle externes, ...). Notre contribution se propose dès lors, à partir d’une analyse de la littérature relativement limitée spécifique à l'objet de recherche particulier que constitue la PMI tunisienne, de mettre en évidence les spécificités de la PMI tunisienne et ses conséquences sur le design d'un système de gouvernance qui permettrait d'asseoir leur crédibilité et donc leur assise dans le paysage économique tunisien. [less ▲]

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See detailCLUPI, a high-performance imaging system on the ESA-NASA rover of the 2018 ExoMars mission to discover biofabrics on Mars
Josset, J.-L.; Westall, F.; Hofmann, B. A. et al

in EGU General Assembly Conference Abstracts (2012, April 01)

The scientific objectives of the ESA-NASA rover of the 2018 mission of the ExoMars Programme are to search for traces of past or present life and to characterise the near-sub surface. Both objectives ... [more ▼]

The scientific objectives of the ESA-NASA rover of the 2018 mission of the ExoMars Programme are to search for traces of past or present life and to characterise the near-sub surface. Both objectives require study of the rock/regolith materials in terms of structure, textures, mineralogy, and elemental and organic composition. The 2018 rover ExoMars payload consists of a suite of complementary instruments designed to reach these objectives. CLUPI, the high-performance colour close up imager, on board the 2018 ESA-NASA Rover plays an important role in attaining the mission objectives: it is the equivalent of the hand lens that no geologist is without when undertaking field work. CLUPI is a powerful, highly integrated miniaturized (<700g) low-power robust imaging system, able to operate at very low temperatures (-120°C). CLUPI has a working distance from 10cm to infinite providing outstanding pictures with a color detector of 2652x1768. At 10cm, the resolution is 7 micrometer/pixel in color. The focus mechanism and the optical-mechanical interface are a smart assembly in titanium that can sustain a wide temperature range. The concept benefits from well-proven heritage: Proba, Rosetta, MarsExpress and Smart-1 missions… Because the main science objective of ExoMars concerns the search for life, whose traces on Mars are likely to be cryptic, close up observation of the rocks and granular regolith will be critical to the decision as whether to drill and sample the nearby underlying materials. Thus, CLUPI is the essential final step in the choice of drill site. But not only are CLUPI's observations of the rock outcrops important, but they also serve other purposes. CLUPI, could observe the placement of the drill head. It will also be able to observe the fines that come out of the drill hole, including any colour stratification linked to lithological changes with depth. Finally, CLUPI will provide detailed observation of the surface of the core drilled materials when they are in the sample drawer at a spatial resolution of 15 micrometer/pixel in color. The close-up imager CLUPI on the ESA-NASA rover of the 2018 mission will be described together with its capabilities to provide important information significantly contributing to the understanding of the geological environment and could identify outstanding potential biofabrics (stromatolites...) of past life on Mars. [less ▲]

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See detailThree quasi-stellar objects acting as strong gravitational lenses
Courbin, F.; Faure, C.; Djorgovski, S. G. et al

in Astronomy and Astrophysics (2012), 540

We report the discovery of three new cases of quasi-stellar objects (QSOs) acting as strong gravitational lenses on background emission line galaxies: SDSS J0827+5224 (z[SUB]QSO[/SUB] = 0.293, z[SUB]s ... [more ▼]

We report the discovery of three new cases of quasi-stellar objects (QSOs) acting as strong gravitational lenses on background emission line galaxies: SDSS J0827+5224 (z[SUB]QSO[/SUB] = 0.293, z[SUB]s[/SUB] = 0.412), SDSS J0919+2720 (z[SUB]QSO[/SUB] = 0.209, z[SUB]s[/SUB] = 0.558), SDSS J1005+4016 (z[SUB]QSO[/SUB] = 0.230, z[SUB]s[/SUB] = 0.441). The selection was carried out using a sample of 22,298 SDSS spectra displaying at least four emission lines at a redshift beyond that of the foreground QSO. The lensing nature is confirmed from Keck imaging and spectroscopy, as well as from HST/WFC3 imaging in the F475W and F814W filters. Two of the QSOs have face-on spiral host galaxies and the third is a QSO+galaxy pair. The velocity dispersion of the host galaxies, inferred from simple lens modeling, is between σ = 210 and 285 km s[SUP]-1[/SUP], making these host galaxies comparable in mass with the SLACS sample of early-type strong lenses. Based on data obtained at the W. M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W. M. Keck Foundation. Also based on observations made with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. These observations are associated with program #GO12233. [less ▲]

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