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See detailIncidence of Abcd1 level on the induction of cell death and organelle dysfunctions triggered by very long chain fatty acids and TNF-alpha on oligodendrocytes and astrocytes
Baarine, Mauhamad; Ragot, Kevin; Athias, Anne et al

in NeuroToxicology (2012), 33(2)

X-linked adrenoleukodystrophy (X-ALD) is characterized by ABCD1 deficiency. This disease is associated with elevated concentrations of very long chain fatty acids (C24:0 and C26:0) in the plasma and ... [more ▼]

X-linked adrenoleukodystrophy (X-ALD) is characterized by ABCD1 deficiency. This disease is associated with elevated concentrations of very long chain fatty acids (C24:0 and C26:0) in the plasma and tissues of patients. Under its severe form, brain demyelination and inflammation are observed. Therefore, we determined the effects of C24:0 and C26:0 on glial cells:oligodendrocytes, which synthesize myelin, and astrocytes, which participate in immune response. So, 158N murine oligodendrocytes, rat C6 glioma cells, rat primary cultures of neuronal–glial cells, and of oligodendrocytes were treated for various periods of time in the absence or presence of C24:0 and C26:0 used at plasmatic concentrations found in X-ALD patients (1–5 μM) and higher (10, 20, 40 μM). To evaluate the importance of extrinsic and intrinsic factors, the part taken by TNF-α and reduced Abcd1 level was studied. Whatever the cells considered, no effects on cell growth and/or viability were detected at 1–5 μM, more or less pronounced effects were identified at 10 μM, and an induction of cell death with increased permeability to propidium iodide and loss of transmembrane mitochondrial potential was observed at 20–40 μM. On 158N, cell death was characterized by (i) an increased superoxide anion production at the mitochondrial level; (ii) the presence of vacuoles of different sizes and shapes; a destabilization of lysosomal membrane and a cytoplasmic redistribution of lysosomes; (iii) a modulation of Abcd3/PMP70 and Acox-1 protein expression, and a decrease in catalase activity at the peroxisomal level. When TNF-α was combined with C24:0 or C26:0 and used on 158N cells, C6 cells, and on 158N cells after siRNA mediated knockdown of Abcd1, no or slight potentiation was revealed. Thus, on the different cell models used, an induction of cell death with marked cellular dysfunctions at the mitochondrial, lysosomal, and peroxisomal levels were found with C24:0 and C26:0 at 20 μM and higher. However, in our experimental conditions, plasmatic concentrations of these fatty acids were unable to induce cell death, and organelle dysfunctions on oligodendrocytes and astrocytes, and additional intrinsic and environmental factors, such as reduced Abcd1 level and/or TNF-α, were ineffective to potentiate their side effects. [less ▲]

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See detailLa primauté de l’intentionnalité et ses conséquences philosophiques
Boccaccini, Federico ULg

Conference (2012, March)

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See detailEvidence of a complex phylogeographic structure in the common dormouse, Muscardinus avellanarius (Rodentia: Gliridae)
Mouton, Alice ULg; Grill, Andrea; Sara, Maurizio et al

in Biological Journal of the Linnean Society (2012), 105(3), 648-664

This is the first mitochondrial phylogeography of the common dormouse, Muscardinus avellanarius (Linnaeus, 1758), a hibernating rodent strictly protected in Europe (Habitat Directive, annex IV; Bern ... [more ▼]

This is the first mitochondrial phylogeography of the common dormouse, Muscardinus avellanarius (Linnaeus, 1758), a hibernating rodent strictly protected in Europe (Habitat Directive, annex IV; Bern Convention, annex III). The 84 individuals of M. avellanarius, sampled throughout the distributional range of the species, have been sequenced at the mitochondrial DNA gene (cytochrome b, 704 base pairs). The results revealed two highly divergent lineages, with an ancient separation around 7.7 Mya and a genetic divergence of 7.7%. Lineage 1 occurs in Western Europe (France, Belgium, and Switzerland) and Italy, and lineage 2 occurs in Central–Northern Europe (Poland, Germany, Latvia, and Lithuania), on the Balkan Peninsula, and in Turkey. Furthermore, these two lineages are subdivided into five sublineages genetically isolated with a strong geographical association. Therefore, lineage 1 branches into two further sublineages (Western European and Italian), whereas lineage 2 contained three sublineages (Central–Northern European, Turkish, and Balkan). We observed low genetic diversity within the sublineages, in contrast to the significant level of genetic differentiation between them. The understanding of genetic population structure is essential for identifying units to be conserved. Therefore, these results may have important implications for M. avellanarius conservation. [less ▲]

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See detailRisques d'introduction des alphavirus responsables des encéphalites virales équines américaines en Belgique
De la Grandière de Noronha Cotta, Maria Ana ULg; Dal Pozzo, Fabiana ULg; Francis, Frédéric ULg et al

Poster (2012, March)

Les virus transmis par des arthropodes hématophages (arbovirus) représentent une menace pour la santé animale et humaine en fonction de l’augmentation de l’émergence des arboviroses en dehors des ... [more ▼]

Les virus transmis par des arthropodes hématophages (arbovirus) représentent une menace pour la santé animale et humaine en fonction de l’augmentation de l’émergence des arboviroses en dehors des territoires endémiques. Les arbovirus étudiés ici appartiennent au genre Alphavirus et à la famille des Togaviridae, et sont composés d’un génome à ARN simple brin de polarité positive et enveloppés. Ces virus sont des pathogènes exotiques des équidés et causent des maladies graves chez l’homme lors d’épidémies. Les arbovirus présentent une épidémiologie complexe car ils se retrouvent au centre de l’interaction avec 5 composants : le virus, le vecteur, le réservoir, les espèces animales sensibles et l’environnement. Les voies d’introduction possible en Belgique de ces virus ont été investiguées ici en fonction des caractéristiques étiologiques et épidémiologiques de chaque virus. L’encéphalite équine de l’Est (EEEV) a un cycle complexe principal incluant les oiseaux et des moustiques comme Culiseta melanura. Les souches nord-américaines et sud-américaines peuvent être différenciées antigéniquement et génétiquement et ont des différences importantes dans leur cycle de transmission et au niveau de leur virulence. Le cycle naturel de l’EEEV se réalise chaque année dans des zones marécageuses et la migration d’oiseaux virémiques serait une hypothèse à sa réintroduction printanière annuelle. Certaines années, le virus peut être amplifié pendant ce cycle oiseaux-moustiques et le virus devient disponible à d’autres espèces de vecteurs qui font le pont entre les oiseaux et les humains ou d’autres mammifères comme les chevaux. Grâce à cette observation, l’EEEV a pu être isolé de vecteur comme Ochlerotatus sollicitans, Coquillettidia perturbans ou encore Culex pipiens et Aedes vexans qui sont deux espèces bien présentes en Europe. Le risque d’importation de l’EEEV semble peu élevé, elle pourrait se faire par l’intermédiaire du transport volontaire ou involontaire, légal ou illégal d’espèces réservoirs d’oiseaux comme des passériformes (ex : moineau domestique ou des oiseaux d’eau (ex : Egretta thula), des rongeurs comme le rat des cotonniers, des vertébrés ectothermiques comme les amphibiens (ex : Rana catesbeiana) ou des reptiles (ex : Agkistrodon piscivorus), ou encore par le transport accidentel de vecteurs compétents. L’encéphalite équine de l’Ouest (WEEV) est retrouvée dans l’Ouest de l’Amérique du Nord et en Amérique du Sud. Ce virus est un virus recombinant entre le Sindbis virus et l’EEEV. Le virus est inclus dans un cycle qui implique des passereaux et Culex tarsalis. Un deuxième cycle moins connu est rapporté et implique un lapin ou lièvre sauvage (Lepus europaeus) avec un moustique du genre Aedes. Comme pour l’EEEV, les humains et les chevaux ne développent pas une virémie suffisante pour infecter les moustiques et continuer le cycle. Le WEEV pourrait être introduit en Europe par différentes voies : les vecteurs arthropodes adultes infectés ou leurs œufs pour Aedes dorsalis, l’introduction d’oiseaux comme des passériformes ou des mammifères comme le lièvre sauvage virémiques. L’acquisition de la compétence d’un vecteur indigène local comme Culex pipiens ou Aedes dorsalis doit aussi être envisagée. Le groupe des virus de l’encéphalite équine vénézuélienne (VEEV) est sous-divisé en souches enzootiques et souches épizootiques qui utilisent le cheval comme hôte amplificateur. Les souches épizootiques sont opportunistes pour leur choix de vecteurs avec comme conséquence un large panel de vecteurs potentiels. L’introduction et l’établissement de ce virus en Belgique est possible via des moustiques infectés, des rongeurs comme le rat des cotonniers ou des oiseaux d’eau infectés, des chevaux et des hommes infectés qui sont des hôtes amplificateurs pour les souches épizootiques. En conclusion, il convient de faire la distinction entre l’introduction et l’établissement d’une infection de ces virus en Belgique. L’introduction peut se faire par l’intermédiaire de vecteurs insectes ou d’hôtes oiseaux ou mammifères comme les rongeurs ou encore le cheval et l’homme dans le cas du VEEV épizootique. Le maintien de l’infection nécessite la présence de vecteurs indigènes avec une compétence vectorielle ou de vecteurs compétents invasifs pour ces virus ainsi que la présence d’hôtes mammifères ou oiseaux phylogénétiquement apparentés à des espèces réservoirs dans les régions américaines où ces virus sont endémiques. [less ▲]

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See detailSpurious oscillations in generalized-alpha time integration methods
Arnold, Martin; Bruls, Olivier ULg; Cardona, Alberto

Conference (2012, March)

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See detailBricolage Planning: Understanding Planning in a Fragmented City
Farah, Jihad ULg; Teller, Jacques ULg

in Polyzos, Serafeim (Ed.) Urban Development (2012)

Planning today is a field in reconstruction where new ways of thinking and making the city are experienced. It is trying to deal with the increasing fragmentation of space and society that is challenging ... [more ▼]

Planning today is a field in reconstruction where new ways of thinking and making the city are experienced. It is trying to deal with the increasing fragmentation of space and society that is challenging its efficacy - even its relevance. In this chapter, by relying on Actor-Network Theory's concepts and case studies of Beirut's suburbs, we observe and analyze new practices, tools and efforts made to charter new ways for gathering resources and organizing collective action. In these case studies, we can see that in a fragmented city and on a local level, urban development initiatives are not necessarily chaotic juxtapositions of autonomous projects. Local networks including different kinds of actors may well be in action. These local networks represent laboratories experimenting governance arrangements, urban planning tools and territory building strategies by using at-hand resources and know-how. We call this planning approach Bricolage Planning. [less ▲]

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See detailFair Trade Organizations and Social Enterprise. Social Innovation through Hybrid Organization Models
Huybrechts, Benjamin ULg

Book published by Routledge (2012)

For several decades, Fair Trade Social Enterprises (FTSEs) have set up partnerships with producer groups in the South and distributed the latter’s products through different types of channels in the North ... [more ▼]

For several decades, Fair Trade Social Enterprises (FTSEs) have set up partnerships with producer groups in the South and distributed the latter’s products through different types of channels in the North. However, while pioneers in the early years were relatively homogeneous (nonprofit organizations relying on voluntary work and selling through “worldshops”), organizational diversity has tremendously increased in recent times, including other types of legal forms, architectures, and governance models (volunteer-based, manager-based, multi-stakeholder, etc.). As a result, different categories of FTSEs now coexist in the sector with diverse missions and strategies. Since Fair Trade (FT) is a hybrid concept, entailing economic, social and political dimensions, the diversity of organizational models might reflect or enable different ways of articulating these dimensions. In other words, different organizational models might be suited for different ways of conceiving and practicing FT. Such an articulation through specific forms has been suggested by previous concepts that can be related to FT, such as cooperatives, the social economy, the solidarity economy, and, more recently, social enterprise. The latter is particularly useful as an umbrella concept that embraces the diverse types of FTSEs and accounts for their use of market mechanisms to pursue social innovation. This research first aims to explore and to structure FTSEs’ organizational diversity. For that purpose, the managers of 57 FTSEs were interviewed in four European regions: Belgium, France (Rhône-Alpes), the United Kingdom (England) and Italy (Rome). Based on the combinations of different elements of the organizational form, five categories emerge: individual FTSEs; entrepreneurial, business-form FTSEs; volunteer-based FTSEs; multi-stakeholder cooperative FTSEs; and group structures. Although certain FTSEs share features corresponding to several models, these categories seem adequate in the sense are relatively homogeneous and distinct from each other. The second question examines the factors or forces that lead FTSEs to adopt particular and diverse organizational forms. Using sociological and economic “new institutional” approaches, this book explores the influence of a number of factors on the organizational form: age, size, region, goals, activities, resources, and leaders’ profiles. From an economic standpoint, organizational diversity may be explained by the fact that FTSEs do not all produce the same types of goods when practicing FT. Thus, FTSEs will adopt the organizational form that minimizes their transaction costs in the production of particular goods. From a sociological standpoint, the analysis suggests that weak and sometimes conflicting institutional pressures explain organizational diversity. Indeed, uniformity is limited (within certain generations of FTSEs or in particular regions), although there is a dominant trend toward a stronger business orientation in the models. The third question examines how organizational actors within FTSEs experience and foster hybridity at the field level, thereby contributing to organizational diversification. Looking at six cases of FTSEs covering the different types of models, the strategic role of FTSEs is examined, as “institutional entrepreneurs” capable of influencing the environment in a way that legitimizes their own organizational model and secures their access to crucial resources. This strategic analysis allows for a more dynamic view of organizational models as “institutional bricolage”. Finally, the book ends with a number of recommendations for FT entrepreneurs on the strengths and the weaknesses of each organizational model. [less ▲]

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See detailInondations en Wallonie, une fatalité ?
Dewals, Benjamin ULg; Pirotton, Michel ULg

Conference given outside the academic context (2012)

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See detailThe usefulness of Ion Mobility-Mass Spectrometry for Small Molecules Analysis
Far, Johann ULg; Goscinny, Séverine ULg; Joly, Laure et al

Conference (2012, March)

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See detailUsage de Facebook par les femmes entrepeneures
Cornet, Annie ULg

Conference given outside the academic context (2012)

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See detailDu laisser-faire au pilotage stratégique ?
Croché, Sarah; Fallon, Catherine ULg

Article for general public (2012)

Présentée comme un instrument clé de la compétitivité régionale depuis la fi n des années nonante, la recherche est l’objet de nombreuses initiatives politiques nationales et européennes. Notamment ... [more ▼]

Présentée comme un instrument clé de la compétitivité régionale depuis la fi n des années nonante, la recherche est l’objet de nombreuses initiatives politiques nationales et européennes. Notamment produite au sein des universités, elle est censée contribuer à la compétitivité de l’Europe sur la scène mondiale et libérer le potentiel d’innovation européen. La note Marcourt propose un renouveau partiel des formes de gouvernance des politiques de recherche en Communauté française qui s’inscrit dans les réformes préconisées par les autorités européennes pour créer l’espace européen de la recherche avec le risque d’un découplage entre recherche et enseignement. Sans compter que ce projet ne dit rien sur le partage des ressources entre équipes universitaires. [less ▲]

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See detailDecision making in noisy bistable switches A local analysis for non local predictions
Trotta, Laura ULg; Bullinger, Eric ULg; Sepulchre, Rodolphe ULg

Conference (2012, March)

In this paper, we try to estimate some statistics about the decision making process in a bistable model submitted to noise by studying the local properties of the system around an hyperbolic saddle point ... [more ▼]

In this paper, we try to estimate some statistics about the decision making process in a bistable model submitted to noise by studying the local properties of the system around an hyperbolic saddle point. Despite the fact that the saddle is not an equilibrium point of the stochastic system, we show that a local approach is still instructive. Under appropriate assumptions, the system can be reduced to an Orsntein-Uhlenbeck process whose dynamics depend on the properties of the saddle point. Yet, Orstein-Uhlenbeck processes have been used to study decision making under uncertainty in a broad variety of fields including statistics and cognitive neurosciences . [less ▲]

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See detailNew Hypotheses on serial offender's spatial behaviour
Trotta, Marie ULg

in Pundt, Hardy; Bernard, Lars (Eds.) Proceedings 1st AGILE PhD School (2012, March)

Geographic profiling is a methodology used to delineate a prior search area for a serial offender. Two new hypotheses integrating recent researches on offender’s behaviour are proposed to broaden the ... [more ▼]

Geographic profiling is a methodology used to delineate a prior search area for a serial offender. Two new hypotheses integrating recent researches on offender’s behaviour are proposed to broaden the applicability of the techniques of geographic profiling to commuters and irregular patterns of crimes. The journeysto- crime variance and place attractiveness will be successively integrated in GP methods. In order to evaluate the variance of the journeys-to-crime on real road network, a method based on least square adjustment in raster mode is developed. A real case of serial rapes illustrates the effectiveness of those assumptions for a non-uniform pattern of crimes. [less ▲]

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See detailApport de la disdrométrie laser au service de la climatologie des hydrométéores
Erpicum, Michel ULg; Fettweis, Xavier; Jorion, Nicolas ULg et al

in Carrega, Pierre (Ed.) Actes des journées de climatologie du CNFG : Climat et Société, Thème : climat et eau, Lyon 2011 (2012, March)

analysis of several rainy days with the support of laser disdrometers in temperate climate (Belgium)

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See detailSpécificités de la proprioception de l’épaule
Forthomme, Bénédicte ULg; Kaux, Jean-François ULg; Crielaard, Jean-Michel ULg et al

in Julia, M.; Hirt, D.; Perrey, S. (Eds.) et al La proprioception (2012)

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See detailFacebook et l'entrepreneuriat féminin
Cornet, Annie ULg

Learning material (2012)

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See detailAberrant results observed with four immuno-assays for total and free prostate-specific antigen (PSA) determination: a case-report
CAVALIER, Etienne ULg

in Clinical Chemistry & Laboratory Medicine (2012), 50(3), 583-584

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See detailG protein-coupled receptors, an unexploited animal toxin targets: Exploration of green mamba venom for novel drug candidates active against adrenoceptors
Maïga, Arhamatoulaye; Mourier, Gilles; Quinton, Loïc ULg et al

in Toxicon (2012), 59

At a time when pharmaceutical companies are having trouble finding new low MW drugs and when biologics are becoming more common, animal venoms could constitute an underexploited source of novel drug ... [more ▼]

At a time when pharmaceutical companies are having trouble finding new low MW drugs and when biologics are becoming more common, animal venoms could constitute an underexploited source of novel drug candidates. We looked for identifying novel animal toxins active against G protein-coupled receptors (GPCR), the most frequently exploited class of treatment targets, with the aim to develop novel research tools and drug candidates. Screening of green mamba (Dendroaspis angusticeps) venom against adrenoceptors identified two novel venom peptides. r-Da1a shown an affinity of 0.35 nM for the a1a-AR while r-Da1b displayed affinities between 14 and 73 nM for the three a2-ARs. These two venom peptides have sequences similar to those of muscarinic toxins and belong to the three-finger-fold protein family. a1a-AR is the primary target for the treatment of prostate hypertrophy. In vitro and in vivo tests demonstrated that r-Da1a reduced prostatic muscle tone as efficiently as tamsulosin (an antagonist presently used), but with fewer cardiovascular side effects. a2-ARs are the prototype of GPCRs not currently used as treatment targets due to a lack of specific ligands. Blockage of these receptors increases intestinal motility, which may be compromised by abdominal surgery and reduces orthosteric hypotension. In vitro and in vivo tests demonstrated that r-Da1b antagonizes a2-ARs in smooth muscles and increased heart rate and blood catecholamine concentrations. These results highlight possible exploitation of r-Da1a and r-Da1b in important pathologies. [less ▲]

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See detailIntroduction. Mise en perspective théorique
Beckers, Jacqueline ULg

in Beckers, Jacqueline; Crinon, Jacques; Simons, Germain (Eds.) Approche par compétences et réduction des inégalités entre élèves : de l’analyse des situations scolaires à la formation des enseignants (2012)

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See detailQuinze ans d'anti-TNF dans la maladie de Crohn: comment tirer le meilleur de cette revolution therapeutique?
Louis, Edouard ULg; REENAERS, Catherine ULg; Meuwis, Marie-Alice ULg et al

in Revue Médicale de Liège (2012), 67 Spec No

After fifteen years of use, the anti-TNF antibodies have become the corner stone of the treatment of moderate and severe Crohn's disease. The skill acquired over the years through experimental trials and ... [more ▼]

After fifteen years of use, the anti-TNF antibodies have become the corner stone of the treatment of moderate and severe Crohn's disease. The skill acquired over the years through experimental trials and clinical experience leads to increased therapeutic efficacy and minimized risks. These antibodies are introduced increasingly earlier in Crohn's disease as well as in a broader range of patients, aiming at changing the natural history of the diseases by avoiding the development of intestinal tissue damage and complications. [less ▲]

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