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See detailDécouverte d’un nouveau cycle du climat
Mabille, Georges ULg; Nicolay, Samuel ULg

Article for general public (2012)

L'outil mathématique "transformée en ondelettes" est appliqué ici à des séries de températures de l'air au sol et met en évidence un cycle de l'ordre de 30 mois. Ce cycle s’observe sur une part importante ... [more ▼]

L'outil mathématique "transformée en ondelettes" est appliqué ici à des séries de températures de l'air au sol et met en évidence un cycle de l'ordre de 30 mois. Ce cycle s’observe sur une part importante de la surface de la planète. [less ▲]

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See detailStudy of the portals of entry of Cyprinid herpesvirus 3 in Cyprinus carpio
Fournier, Guillaume ULg

Doctoral thesis (2012)

The common carp is one of the most important freshwater species in aquaculture and its colourful subspecies koi is grown for personal pleasure and exhibitions. Both subspecies are economically important ... [more ▼]

The common carp is one of the most important freshwater species in aquaculture and its colourful subspecies koi is grown for personal pleasure and exhibitions. Both subspecies are economically important. In the 1990s, a highly contagious and lethal pathogen called koi herpesvirus (KHV) or cyprinid herpesvirus 3 (CyHV-3) began to cause severe financial losses in these two carp industries worldwide. Because of its economic importance and its numerous original biological properties, CyHV 3 became rapidly an attractive subject for applied and fundamental research. The goal of this thesis was to identify the portals of entry of CyHV-3 in carp. This information is essential to understand the pathogenesis and the epidemiology of the infection, but also to develop efficacious vaccines. Prolonged CyHV-3 cultivation in vitro leads to the spontaneous attenuation of the virus. To circumvent this problem, the entire viral genome was cloned as a bacterial artificial chromosome (BAC). Then to test the usefulness of the BAC clone, several recombinants strains were generated as described in the first chapter. In the second chapter, we took profit of the CyHV-3 BAC clone to produce a recombinant strain encoding a firefly luciferase (LUC) expression cassette. Infection of carp by immersion in water containing the CyHV-3 LUC strain demonstrated, using bioluminescent in vivo imaging system (IVIS), that the skin, and not the gills, is the major portal of entry for CyHV-3. Fish skin provides mechanical, chemical and immune protection against injury and pathogenic microorganisms. Its mucus layer confers an innate immune protection against pathogen entry. However, there is little in vivo evidence on the role of skin mucus as a first line of innate immune protection against bacterial and viral infections. In the third chapter, we used the CyHV-3 LUC strain and IVIS to investigate the roles of epidermal mucus as an innate immune barrier against CyHV-3 entry. Our results demonstrate that the mucus of the skin inhibits CyHV-3 binding to epidermal cells and contains soluble molecules able to neutralize CyHV-3 infectivity. The skin is the major portal of entry after inoculation by immersion in water containing CyHV-3. While this model of infection mimics some natural conditions in which infection takes place, other epidemiological conditions could favor entry of virus through the digestive tract. Consequently, in the fourth and last chapter, we investigated the role of the carp digestive tract as a viral portal of entry using bioluminescence imaging. We found that feeding carp with infectious materials induces CyHV-3 entry through infection of the pharyngeal periodontal mucosa. In conclusion, this study demonstrated that according to epidemiological conditions, CyHV-3 can enter carp either through infection of the skin (immersion in infectious water) or through infection of the pharyngeal periodontal mucosa (feeding on infectious materials). The existence of these two portal of entry adapted to different epidemiological conditions most probably contributes to the high contagious nature of the virus. [less ▲]

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See detailL'interprétation réaliste des jugements existentiels de Conrad-Martius
Seron, Denis ULg

Conference (2012, April 06)

Hedwig Conrad-Martius a développé, dans les années 1930, une conception en grande partie originale du jugement existentiel, dans la perspective d’une ontologie d’allure aristotélicienne. L’idée à la base ... [more ▼]

Hedwig Conrad-Martius a développé, dans les années 1930, une conception en grande partie originale du jugement existentiel, dans la perspective d’une ontologie d’allure aristotélicienne. L’idée à la base de cette conception est que l’être existentiel et l’être copule sont unis par une relation d’analogie, et que celle-ci doit servir de principe directeur pour la clarification des « sens de l’être ». Cette idée a conduit Conrad-Martius à élaborer une théorie assez sophistiquée de l’« être immanent à l‘état de choses », ainsi qu’une conception réaliste suivant laquelle le prédicat existentiel exprime une propriété de premier degré, qui doit être mise au jour par l’intuition des essences. On s’attachera non seulement à détailler son analyse du jugement existentiel, en remontant à ses sources chez Reinach, Pfänder et, indirectement, chez Meinong, mais aussi à en clarifier quelques implications métaphysiques. [less ▲]

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See detailAPA@ULg : les normes de l'A.P.A. (American Psychological Association)
Thirion, Paul ULg; Durieux, Nancy ULg

Learning material (2012)

Site destiné à expliquer les principales règles de l'American Psychological Association (APA) en matière de citations, de présentation de la liste des références et de présentation des tableaux et figures ... [more ▼]

Site destiné à expliquer les principales règles de l'American Psychological Association (APA) en matière de citations, de présentation de la liste des références et de présentation des tableaux et figures dans un document scientifique. Le site comporte une série d'exemples et quelques adaptations au contexte francophone. [less ▲]

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See detailRaymond De Becker et l'identité belge
Lanneau, Catherine ULg

Conference (2012, April 05)

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See detailCharacterisation of macadamia nuts using X-ray microtomography
Plougonven, Erwan ULg; Srichamnong, Warangkana; Srzednicki, George et al

in Micro-CT User Meeting Abstract Book (2012, April 05)

Macadamia nuts are among the most nutritious and highest in monounsaturated oil content among edible nuts1. They are widely grown in Australia (46 % of total production), United States of America ... [more ▼]

Macadamia nuts are among the most nutritious and highest in monounsaturated oil content among edible nuts1. They are widely grown in Australia (46 % of total production), United States of America, especially in Hawaii, South Africa and Guatemala2. In practice, there are several steps involved in macadamia processing, including sorting and grading, drying, cracking, roasting, packaging and storage. Drying is a very crucial step as it needs to preserve macadamia quality as well as enhance storage stability through the reduction of water activity. It is obvious that physical properties of the nut contribute to its drying characteristics, and hence its storage stability. Accurate measures such as kernel volume ratio or shell density could help for improving drying efficiency. We present a methodology to investigate structural differences between varieties of macadamia nuts in order to understand the factors involved in storage stability. Fresh nuts-in-shell are scanned by X-ray microtomography, and the different parts of the nuts (shell, kernel, tracheids) are segmented by a set of classical 3D image operators. After image segmentation, volumes are determined, and additional weighing of the nuts allows density measurements. These quantities are plotted for several nuts from each variety. [less ▲]

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See detailDifferential usage of NF-kB activating signals by IL-1b and TNF-a in pancreatic beta cells
Ortis, Fernanda; Miani, M; Colli, ML et al

in FEBS Letters (2012), 586

The cytokines interleukin (IL)-1b and tumor necrosis factor (TNF)-a induce b-cell death in type 1 diabetes via NF-kB activation. IL-1b induces a more marked NF-kB activation than TNF-a, with higher ... [more ▼]

The cytokines interleukin (IL)-1b and tumor necrosis factor (TNF)-a induce b-cell death in type 1 diabetes via NF-kB activation. IL-1b induces a more marked NF-kB activation than TNF-a, with higher expression of genes involved in b-cell dysfunction and death. We show here a differential usage of the IKK complex by IL-1b and TNF-a in b-cells. While TNF-a uses IKK complexes containing both IKKa and IKKb, IL-1b induces complexes with IKKa only; this effect is achieved by induction of IKKb degradation via the proteasome. Both IKKg and activation of the TRAF6-TAK1-JNK pathway are involved in IL-1b-induced IKKb degradation. [less ▲]

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See detailInterregionalism and emerging powers
Santander, Sébastian ULg

Scientific conference (2012, April 05)

La communication analyse les rapport entre le phénomène interrégional et les puissances émergentes.

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See detailLa lutte contre les abus passe par l'Union européenne
Defossez, Alexandre ULg

Article for general public (2012)

Le drame de Wingene, dans lequel deux chauffeurs routiers polonais ont tragiquement perdu la vie, a jeté une lumière crue sur les conditions de travail parfois déplorables de certains travailleurs issus ... [more ▼]

Le drame de Wingene, dans lequel deux chauffeurs routiers polonais ont tragiquement perdu la vie, a jeté une lumière crue sur les conditions de travail parfois déplorables de certains travailleurs issus des pays de l’Est. [less ▲]

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See detailWhat if the colicky horse has no colic?
Van Galen, Gaby ULg

in Catherine Delesalle (Ed.) Proceedings of "De Voorjaarsdagen" (2012, April 05)

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See detailCn. Octavius (cos. 165) dans un nouveau sénatus-consulte découvert à Volos ?
Famerie, Etienne ULg

Scientific conference (2012, April 04)

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See detailVoir/savoir. Le partage du sensible
Havelange, Carl ULg

Conference (2012, April 04)

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See detailThe role of segmentation and investor recognition trough the lens of cross-listing activity
Mouchette, Xavier ULg; Carrieri, Francesca; Muller, Aline ULg

Scientific conference (2012, April 04)

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See detailContribution of high mass resolution and accuracy of FTMS to molecular imaging
Debois, Delphine ULg; Calligaris, David ULg; Cimino, Jonathan ULg et al

Conference (2012, April 04)

Since its first implementation in 1997, MALDI Mass Spectrometry Imaging (MALDI MSI) has become an important tool in the proteomic arsenal, especially for biomarker hunting. First dedicated to high ... [more ▼]

Since its first implementation in 1997, MALDI Mass Spectrometry Imaging (MALDI MSI) has become an important tool in the proteomic arsenal, especially for biomarker hunting. First dedicated to high molecular weight, MALDI MSI is more and more used to map the distribution of small molecules too (lipids, drugs and metabolites,…). Last developments tend to improve the sample treatments to obtain the best spatial resolution as possible. From this perspective, great efforts have been made on the MALDI matrix deposition methods. Now, one of the remaining challenges for MALDI-MSI users consists of identification of detected molecules. For high molecular weight, methods inspired by classical proteomics techniques, are regularly used. Bottom-Up (PMF obtained after in situ trypsin digestion) and Top-Down (in situ In-Source Decay) approaches have been used directly from a tissue slice, leading to the identification of some of the most abundant proteins present at the surface of the tissue. When small molecules are analyzed, the identification is more straightforward. Indeed, tandem mass spectrometry can easily be used, leading to the fragmentation of the detected compounds which allows their unambiguous identification. This identification is even more reliable when high resolution exact mass measurements can be performed. In this talk, I will present how in our lab, we profit of the exceptional features of FT-ICR mass spectrometry for imaging and especially for identification purposes. The first example will deal with the benefit of high mass accuracy and high mass resolution for ISD-based protein identification. The mass accuracy and high mass resolution coupled with the use of a “cleaning” software allow unequivocal assignment of ISD fragments of proteins, in the low mass range (m/z between 300 and 900), whether from pure solutions or from tissue slices. The next examples will deal with the imaging of small molecules. The identification of drugs and their metabolites is facilitated with high mass accuracy. In our lab, we work on the localization of methadone and its first metabolite, EDDP in necrophagous fly larvae. In the mass range of these compounds (278-310 m/z), many matrix ion peaks are detected and the unique features of FT-ICR allows for unambiguous identification thanks to exact mass measurements. We also use MALDI Imaging to map the messenger molecules between plant roots and beneficial bacteria. The comparison of spectra recorded with a TOF/TOF instrument and with a FT-ICR demonstrates that high resolution allows for detecting molecules which could have been missed otherwise. It also allows to distinguish unknown compounds from alkali adducts of known molecules. [less ▲]

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See detailGus Van Sant. Le cinéma en bohème
Tomasovic, Dick ULg

Scientific conference (2012, April 04)

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See detailSurface water diffuse pollution by PPP: focus on runoff & erosion
Bah, Boubacar Billo ULg; Vandendael, Laurent; Oger, Robert ULg et al

Conference (2012, April 04)

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See detailCALCIUM HYDROXIDE LOADED PLGA MICROSPHERES FOR ENDODONTICS: EFFECT OF FORMULATION METHOD ON Ca++ RELEASE PROFILE
Chavarria Bolanos, Daniel ULg; Cerda-Cristerna, BI; Flores-Reyes, Hector et al

Poster (2012, April 04)

Detailed reference viewed: 24 (1 ULg)