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See detailDynamic interaction between lymphoid tyrosine phosphatase and C-terminal Src kinase controls T cell activation
Tautz, Lutz; Vang, Torkel; Liu, Wallace et al

in FASEB Journal (2012, April), 26

Lymphoid tyrosine phosphatase (LYP) and C-terminal Src kinase (CSK) are negative regulators of signaling mediated through the T cell antigen receptor (TCR) and are thought to act in a cooperative manner ... [more ▼]

Lymphoid tyrosine phosphatase (LYP) and C-terminal Src kinase (CSK) are negative regulators of signaling mediated through the T cell antigen receptor (TCR) and are thought to act in a cooperative manner when forming a complex. Here, we show that dissociation of the LYP/CSK complex is necessary for recruitment of LYP to lipid rafts, where it down-modulates TCR-mediated signaling. Our findings may also explain the reduced TCR signaling associated with a single nucleotide polymorphism, which confers increased risk for autoimmunity and results in the expression of a LYP allele that can no longer bind CSK. Development of a potent and selective chemical probe of LYP allowed us to confirm that the observed down-modulation of TCR-induced signaling was due to the LYP catalytic activity. Our compound also represents a starting point for the development of a LYP-based treatment of autoimmunity. [less ▲]

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See detailL’homme de lettres en personnage générique. La ‘‘sociologie-fiction’’ des Physiologies
Stienon, Valérie ULg

in Dozo, Björn-Olav; Glinoer, Anthony; Lacroix, Michel (Eds.) Imaginaires de la vie littéraire. Fiction, figuration, configuration (2012)

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See detailÉtude des liens entre facteurs de croissance, consommation de lait et de produits laitiers et cancers
Boutron-Ruault, Marie-Christine; Bruyère, Olivier ULg; Charriere, Sybil et al

Report (2012)

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See detailExpansion of the main auroral oval at Jupiter : evidence for Io’s control over the Jovian magnetosphere
Bonfond, Bertrand ULg; Grodent, Denis ULg; Gérard, Jean-Claude ULg et al

Poster (2012, April)

In spring 2007, New Horizons' Jupiter fly-by provided a unique opportunity for the largest observation campaign dedicated to the Jovian aurora ever carried out by the Hubble Space Telescope. UV images of ... [more ▼]

In spring 2007, New Horizons' Jupiter fly-by provided a unique opportunity for the largest observation campaign dedicated to the Jovian aurora ever carried out by the Hubble Space Telescope. UV images of the aurora have been acquired on a quasi-daily basis from mid-February to mid-June 2007. Polar projection of the auroral emissions clearly show a continuous long-term expansion of main oval additionally to day by day variations. The main oval moved so much that the Ganymede footprint, which is usually located equatorward of the main emissions, has even been observed inside of it. Simultaneously, the occurrence rate of large equatorward isolated auroral features increased over the season. These emission patches are generally attributed to injections of depleted flux tubes. On 6th June, one of these features exceptionally moved down to the Io footpath. The Io footprint seemed to disappear while the footprint moved through this patch of emission. This disappearance is a unique case among all the UV images of the aurora acquired during the last 12 years. We suggest that all these changes seen in the Jovian aurora are evidence for a major reconfiguration of the magnetosphere induced by increased volcanic activity on Io. Indeed, New Horizons observed particularly intense activity from the Tvashtar volcano in late February 2007. Moreover, sodium cloud brightening caused by volcanic outbursts have also been seen in late May 2007. According to our interpretation, repeated volcanic outbursts beefed up the plasma torus density and its mass outflow rate. This caused the corotation breakdown boundary to migrate closer to Jupiter. Consequently, the main auroral oval moved equatorward. As heavy flux tubes move outward, sparsely filled ones should be injected into the inner magnetosphere in order to conserve the magnetic flux in this region. This phenomenon could explain the large number of injection signatures observed in May-June 2007. Such a cloud of depleted flux tubes probably disrupted the Io-magnetosphere interaction, leading to an abnormally faint Io footprint. [less ▲]

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See detailTyrosine-dependent capture of CAP-Gly domain‐containing proteins in complex mixture by EB1 C-terminal peptidic probes
Calligaris, David ULg; Manatschal, Cristina; Marcellin, Marlène et al

in Journal of Proteomics (2012), 75

Microtubule dynamics is regulated by an array of microtubule associated proteins of which the microtubule plus-end tracking proteins (+TIPs) are prominent examples. +TIPs form dynamic interaction networks ... [more ▼]

Microtubule dynamics is regulated by an array of microtubule associated proteins of which the microtubule plus-end tracking proteins (+TIPs) are prominent examples. +TIPs form dynamic interaction networks at growing microtubule ends in an EB1-dependent manner. The interaction between the C-terminal domain of EB1 and the CAP-Gly domains of the +TIP CLIP-170 depends on the last tyrosine residue of EB1. In the present study, we generated peptidic probes corresponding to the C-terminal tail of EB1 to affinity-capture binding partners from cell lysates. Using an MS-based approach, we showed that the last 15 amino-acid residues of EB1, either free or immobilized on beads, bound recombinant CAP-Gly domains of CLIP-170. We further demonstrate that this binding was prevented when the C-terminal tyrosine of EB1 was absent in the peptidic probes. Western blotting in combination with a label-free quantitative proteomic analysis revealed that the peptidic probe harboring the C-terminal tyrosine of EB1 effectively pulled-down proteins with CAP-Gly domains from endothelial cell extracts. Additional proteins known to interact directly or indirectly with EB1 and the microtubule cytoskeletonwere also identified. Our peptidic probes represent valuable tools to detect changes induced in EB1-dependent +TIP networks by external cues such as growth factors and small molecules. [less ▲]

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See detailBelgium’s political elites and the crisis
Dodeigne, Jérémy ULg; Sinardet, Dave; Reuchamps, Min ULg

Conference (2012, April)

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See detailPresentation of the report about degradation inhibitors and metal additives impact on solvent degradation
Léonard, Grégoire ULg

Report (2012)

Literature review about impact of additives on solvent degradation

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See detail"Le lieu géométrique de toutes les agitations" : écrivains fictifs et prix littéraires
Dozo, Björn-Olav ULg; Lacroix, Michel

in Dozo, Björn-Olav; Glinoer, Anthony; Lacroix, Michel (Eds.) Imaginaires de la vie littéraire. Fiction, figuration, configuration (2012)

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See detailExpression of specific pathways in the inflamed synovial membrane of osteoarthritis patient: Identification of new potential key intermediates
Lambert, Cécile ULg; Dubuc, Jean-Emile; Hennuy, Benoît ULg et al

in Osteoarthritis and Cartilage (2012, April), 20(Supplement 1), 56

Purpose: Synovitis is a key factor in osteoarthritis (OA) pathophysiology, contributing to both patient symptoms and disease progression. In this study, using an original methodology comparing normal ... [more ▼]

Purpose: Synovitis is a key factor in osteoarthritis (OA) pathophysiology, contributing to both patient symptoms and disease progression. In this study, using an original methodology comparing normal/reactive (N/R) and inflammatory (I) synovial membranes zones, we investigated the gene expression profiles of synovial cells from these areas and identified differentially regulated pathways. <br />Methods: Synovial cells (SC) were isolated from OA synovial specimens obtained from 12 patients undergoing knee replacement. The inflammatory status of the synovial membrane was characterized by the surgeon according to macroscopic criteria including the synovial vascularization, the villi formation and the hypertrophic aspect of the tissue. At the surgery time, the synovial membrane was dissected and biopsies from N/R and I areas cultured separately for a period of 7 days. Total RNA was extracted using the RNeasy Mini Kit. RNA purity and quality were evaluated using the Experion RNA StdSens Analysis kit (Bio-rad Laboratories). Gene expression profiling between N/R and I areas was performed using Illumina’s multi-sample format Human HT-12 BeadChip (Illumina Inc.). Differential analysis was performed with the BRB array tools software. Class Comparison test between N/R and I areas was based on paired t-test where N/R and I were paired for each patient. The biological relevance of up- and down-regulated genes was analyses with Ingenuity Pathways Analysis (Ingenuity® Systems). Western blot was performed to confirm certain intermediate expression. <br />Results: From among 47000 probes, 17500 were filtered out. Probes with a p-value below than 0.005 were chosen and classified as up- or down-regulated ones. By this way, 896 differentially expressed genes between N/R and I zones were identified. Among these, 576 genes were upregulated (I/NR > 1.5) and 320 downregulated (I/NR < 0.75). With Ingenuity Pathways Analysis, a significant number of the top ranking differentially expressed genes were identified as inflammatory, Wnt and angiogenic pathways. Interleukin (IL)-6 and -8, chemokines (CXCL1, CXCL2, CXCL5, CXCL6, CXCL16) and arachidonate 5-lipoxygenase (ALOX5) were identified as the most upregulated in I zones in the inflammatory pathway. Interestingly, the alarmin S100A9 was found strongly upregulated in this pathway. Wnt5A and LRP (Low density lipoprotein receptor-related protein) 5 were upregulated whereas FZD (Frizzled homolog) 2 and DKK (dickkopf homolog) 3 were downregulated in the Wnt signaling pathway. Finally, stanniocalcin (STC)-1, an intermediate in angiogenesis was identified as the most upregulated gene in I zones compared to N/R zones. This difference of expression was confirmed at the protein level. <br />Conclusions: Using a unique culture system, this study is the first to identify different expression pattern between two areas of synovial membrane from the same OA patient. These differences concern several key pathways involved in OA pathogenesis, i.e. inflammation, Wnt and angiogenesis. This analysis also provided interesting information regarding new potent intermediates as S100A9 and STC-1. They could be potential targets for chondroitin sulfate, one of the most used molecules in the management of OA. New experiments are being perfomed at the moment to elucidate the potential effect of this molecule on these specific differentially expressed genes in the same culture system. [less ▲]

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See detailDo Identities Matter More than Party Interests in Ethno-Territorial Politics? Conceptual and Empirical Insights from Multilevel and Deeply Divided Belgium
Reuchamps, Min ULg; Dodeigne, Jérémy ULg; Sinardet, Dave

Conference (2012, April)

In territorial politics, identities are a chief variable of the political life. By definition, the ethno-linguistic identities play(ed) an important role in the political dynamics of several highly ... [more ▼]

In territorial politics, identities are a chief variable of the political life. By definition, the ethno-linguistic identities play(ed) an important role in the political dynamics of several highly divided societies. In most cases, the institutional design is in fact adapted or has been adapted to the ethno-linguistic divisions of the country. According to quite a few scholars, it is especially true for political elites who are not only shaped by this variable but also use this variable to legitimate their attitudes and actions. Therefore political elites of each ethno-linguistic group appeared to behave as monolithic blocks, standing against each other along ethno-linguistic lines. Nonetheless, this view neglects the role of party interests in explaining the behaviors of political elites. An important question for ethno-territorial politics should be raised: do identities matter more that party interests? The current reform of the – multilevel and deeply-divided – Belgian state provides a fertile ground to test this hypothesis. To what extent, party interests can account for political elites’ position in the debate about the 6th Belgian constitutional reform? To explore these questions, we surveyed every representative of Belgium’s seven legislative assemblies with a standardized questionnaire (Summer 2011). This research will help us apprehend the rationale behind political elites’ attitudes – be it identities, party interests or a mix of them – negotiating the new boundaries of the state and above all shed light on territorial politics in Europe. So doing, this paper aims at contributing to the debate that explores the possibility of a unified analytical approach bridging ethno-territorial politics and party politics. [less ▲]

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See detailL1-based compression of random forest models
Joly, Arnaud ULg; Schnitzler, François ULg; Geurts, Pierre ULg et al

in 20th European Symposium on Artificial Neural Networks (2012, April)

Random forests are effective supervised learning methods applicable to large-scale datasets. However, the space complexity of tree ensembles, in terms of their total number of nodes, is often prohibitive ... [more ▼]

Random forests are effective supervised learning methods applicable to large-scale datasets. However, the space complexity of tree ensembles, in terms of their total number of nodes, is often prohibitive, specially in the context of problems with very high-dimensional input spaces. We propose to study their compressibility by applying a L1-based regularization to the set of indicator functions defined by all their nodes. We show experimentally that preserving or even improving the model accuracy while significantly reducing its space complexity is indeed possible. [less ▲]

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See detailSPM for MEG/EEG
Phillips, Christophe ULg

Scientific conference (2012, April)

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See detailEl papel de los academicos en la sociedad del conocimiento
Jacquemain, Marc ULg

in Casas Guerrero, Rosalba; Carton de Grammont, Hubert (Eds.) Democracia, conocimiento y cultura (2012)

Los academicos en la sociedad del concocimiento tienen a la vez un papel de expertos y de ciudadanos. Su funcion en la sociedad del conocimiento supone que sus cualficaciones como expertos vengan en apoyo ... [more ▼]

Los academicos en la sociedad del concocimiento tienen a la vez un papel de expertos y de ciudadanos. Su funcion en la sociedad del conocimiento supone que sus cualficaciones como expertos vengan en apoyo al funcionamiento democratico de la sociedad lo que les impide actuar sencillamente como profesionales sinon tambien como actores democraticos. [less ▲]

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See detailLes querelles littéraires : esquisse méthodologique
Stienon, Valérie ULg; Saint-Amand, Denis ULg; Bertrand, Jean-Pierre ULg

in COnTEXTES : Revue de Sociologie de la Littérature (2012), 10

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See detailPrecision of continuous neonatal ventilator respiratory mechanics is improved with selected optimal respiratory cycles.
RIGO, Vincent ULg; Graas, Estelle; RIGO, Jacques ULg

in European journal of pediatrics (2012), 171(4), 689-96

Given their high apparent variability, bedside continuous respiratory mechanics (RM) parameters (excepting tidal volume (VT)) remain infrequently used for adjustment of neonatal ventilatory settings. RM ... [more ▼]

Given their high apparent variability, bedside continuous respiratory mechanics (RM) parameters (excepting tidal volume (VT)) remain infrequently used for adjustment of neonatal ventilatory settings. RM parameters provided by ventilator (VRC) from 10 recordings of newborns (10 minutes in synchronized intermittent mandatory ventilation and Assist/control (A/C)) were compared to those computed from visually selected assisted leak-free optimal respiratory cycles (SRC). Mean values, variability and ability to distinguish patients were compared between VRC and SRC. Dynamic resistances were more correlated (r²=0.95) than compliances (r²=0.42). VT’s were correlated only in A/C (r²=0.78). C20/C was significantly higher in VRC (1.81±0.67) than in SRC (1.23±0.36) and frequently out of neonatal reference range. In A/C ventilation, VT was higher in VRC (5.6 ±1.8 ml/kg) than in SRC (4.8 ±1.0 ml/kg) (p<0.05). Displayed VT’s don’t reflect those found in optimal assisted breaths and therefore have incomplete value in assessing adequacy of ventilator settings. The variability of RM parameters provided by the ventilator is large, and coefficients of variation were significantly lower with optimal respiratory cycles (for Resistance, Compliance, VT and C20/C: 27, 26, 18, 24% in SRC, 36, 35, 40, 33% in VRC). Selecting optimal cycles yields RM with a 2-3 times higher discriminating power between patients. Conclusion: Current ventilator’s RM parameters have limited clinical use. Using optimal breaths to calculate RM parameters improves precision and discriminating power. For integration to ventilatory care, automation of this selection must be implemented first. [less ▲]

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See detailLa culturalisation du politique
Jacquemain, Marc ULg

Article for general public (2012)

Les valeurs que nous croyons enracinées dans une partie du champ idéologique deviennent de plus en plus nomade. On examine brièvement pourquoi la laïcité, valeur historiquement portée par la gauche, est ... [more ▼]

Les valeurs que nous croyons enracinées dans une partie du champ idéologique deviennent de plus en plus nomade. On examine brièvement pourquoi la laïcité, valeur historiquement portée par la gauche, est aujourd'hui intégréee au dispositif idéologique de la droite la plus radicale. On examine brièvement le cas de la laïcité. [less ▲]

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See detailCumulative pregnancy rate after ICSI-IVF in patients with colorectal endometriosis: results of a multicentre study.
Ballester, Marcos; d'Argent, EM; Morcel, K et al

in Human Reproduction (2012), 27(4), 1043-9

BACKGROUND: There is currently no consensus about indications for surgery for infertility associated with colorectal endometriosis. The aim of this study was to evaluate cumulative pregnancy rates (CPRs ... [more ▼]

BACKGROUND: There is currently no consensus about indications for surgery for infertility associated with colorectal endometriosis. The aim of this study was to evaluate cumulative pregnancy rates (CPRs) after ICSI-IVF cycles in patients with colorectal endometriosis and to identify determinant factors of fertility outcome. METHODS: Prospective longitudinal multicentre study from January 2005 to June 2011. We included 75 patients with colorectal endometriosis and proved infertility without prior surgery for deep infiltrating endometriosis. Univariable analysis was used to identify determinant factors of pregnancy rate. CPR was calculated using cumulative-incidence methods from log-rank test and Kaplan-Meier curves. For multivariable analysis, Cox proportional hazards model was used. RESULTS: For CPR per patient analysis, the total number of cycles was 113 and the median number of cycles per patient was 1 (range: 1-3). In the whole population the CPR per patient after three ICSI-IVF cycles was 68.6%. The CPR for patients with or without associated adenomyosis was 19 and 82.4%, respectively (P= 0.01). In addition, a patient age over 35 years (P= 0.02) and anti-Mullerian hormone serum level under 2 ng/ml (P= 0.02) were associated with a decreased CPR per patient. At multivariable analysis, adenomyosis [HR = 0.34, 95% CI (0.12-0.99), P= 0.49] was associated with a decreased CPR. CONCLUSIONS: Our data confirm that ICSI-IVF offers a high CPR per patient. However, determinant factors of CPR should be taken into account when informing couples of their options. [less ▲]

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See detailEngineering geological mapping in Wallonia (Belgium) : present state and recent computerized approach
Delvoie, Simon ULg; Radu, Jean-Pol ULg; Ruthy, Ingrid ULg et al

Poster (2012, April)

An engineering geological map can be defined as a geological map with a generalized representation of all the components of a geological environment which are strongly required for spatial planning ... [more ▼]

An engineering geological map can be defined as a geological map with a generalized representation of all the components of a geological environment which are strongly required for spatial planning, design, construction and maintenance of civil engineering buildings. In Wallonia (Belgium) 24 engineering geological maps have been developed between the 70s and the 90s at 1/5,000 or 1/10,000 scale covering some areas of the most industrialized and urbanized cities (Liège, Charleroi and Mons). They were based on soil and subsoil data point (boring, drilling, penetration test, geophysical test, outcrop. . . ). Some displayed data present the depth (with isoheights) or the thickness (with isopachs) of the different subsoil layers up to about 50 m depth. Information about geomechanical properties of each subsoil layer,useful for engineers and urban planners, is also synthesized. However, these maps were built up only on paper and progressively needed to be updated with new soil and subsoil data. The Public Service of Wallonia and the University of Liège have recently initiated a study to evaluate the feasibility to develop engineering geological mapping with a computerized approach. Numerous and various data (about soil and subsoil) are stored into a georelational database (the geotechnical database – using Access, Microsoft®). All the data are geographically referenced. The database is linked to a GIS project (using ArcGIS, ESRI®). Both the database and GIS project consist of a powerful tool for spatial data management and analysis. This approach involves a methodology using interpolation methods to update the previous maps and to extent the coverage to new areas. The location (x, y, z) of each subsoil layer is then computed from data point. The geomechanical data of these layers are synthesized in an explanatory booklet joined to maps. [less ▲]

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See detailMechanical Ventilation During Anaesthesia: Pathophysiology and Clinical Implications
Dresse, Caroline; JORIS, Jean ULg; HANS, Grégory ULg

in Trends in Anaesthesia and Critical Care (2012), 2(2), 71-75

Detailed reference viewed: 15 (3 ULg)