References of "2012"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailMotor fatigue measurement by distance-induced slow down of walking speed in multiple sclerosis
PHAN BA, Remy ULg; CALAY, Philippe ULg; GRODENT, Patrick ULg et al

in PLoS ONE (2012), 7(4), 34744

Background: Motor fatigue and ambulation impairment are prominent clinical features of people with multiple sclerosis (pMS). We hypothesized that a multimodal and comparative assessment of walking speed ... [more ▼]

Background: Motor fatigue and ambulation impairment are prominent clinical features of people with multiple sclerosis (pMS). We hypothesized that a multimodal and comparative assessment of walking speed on short and long distance would allow a better delineation and quantification of gait fatigability in pMS. Objectives: To compare 4 walking paradigms: the timed 25-foot walk (T25FW), a corrected version of the T25FW with dynamic start (T25FW+), the timed 100-meter walk (T100MW) and the timed 500-meter walk (T500MW). Methods: Thirty controls and 81 pMS performed the 4 walking tests in a single study visit. Results: The 4 walking tests were performed with a slower WS in pMS compared to controls even in subgroups with minimal disability. The finishing speed of the last 100-meter of the T500MW was the slowest measurable WS whereas the T25FW+ provided the fastest measurable WS. The ratio between such slowest and fastest WS (Deceleration Index, DI) was significantly lower only in pMS with EDSS 4.0-6.0, a pyramidal or cerebellar functional system score reaching 3 or a maximum reported walking distance !4000m. Conclusion: The motor fatigue which triggers gait deceleration over a sustained effort in pMS can be measured by the WS ratio between performances on a very short distance and the finishing pace on a longer more demanding task. The absolute walking speed is abnormal early in MS whatever the distance of effort when patients are unaware of ambulation impairment. In contrast, the DI-measured ambulation fatigability appears to take place later in the disease course. [less ▲]

Detailed reference viewed: 101 (11 ULg)
Full Text
See detailUnderstanding of the Venus upper atmosphere dynamics with O2(a1 ) Venus Express observations
Soret, Lauriane ULg; Gérard, Jean-Claude ULg; Piccioni, Giuseppe et al

Poster (2012, April)

The O2(a1 ) nightglow emission at 1.27 m may be used as a tracer of the dynamics prevailing in the Venusian upper mesosphere. This emission has thus been observed with ground-based telescopes and from ... [more ▼]

The O2(a1 ) nightglow emission at 1.27 m may be used as a tracer of the dynamics prevailing in the Venusian upper mesosphere. This emission has thus been observed with ground-based telescopes and from space with instruments such as VIRTIS on board Venus Express. Observations have shown that the emission maximum is statistically located close to the antisolar point at 96 km. As originally suggested by Connes et al. (1979), such an emission results from the production of oxygen atoms on the Venus dayside by photodissociation and electron impact dissociation of CO2 and CO, which are then transported to the nightside by the subsolar to antisolar general circulation, where they recombine to create excited O2(a1 ) molecules. Their radiative deexcitation produces the O2(a1 ) nightglow with a maximum near the antisolar point. However, VIRTIS observations indicate that the O2(a1 ) nightglow emission is highly variable, both in intensity and location. Actually, when considering individual observations, the patch of bright emission is rarely located at the antisolar point and the brighter area around this point is the result of statics accumulation. Also, when considering several individual observations acquired in a short period of time, it is possible to follow an individual emission patch and to deduce its displacement and its brightness variation due to activation or deactivation. In this study, we analyze several sequences of VIRTIS observations in order to understand the Venus upper mesosphere dynamics.We show that the intensity can vary by several megaRayleighs in a couple of hours with effective lifetimes on the order of several hours. The horizontal motion of the spots leads to the conclusion that winds in the 95-100 km region are in the range of 25 to 150 m s-1, in good agreement with the study by Hueso et al. (2008). [less ▲]

Detailed reference viewed: 41 (9 ULg)
Full Text
See detail"Les testaments"
Moreau, Pierre ULg

in Chroniques notariales, vol. 55 (2012)

Detailed reference viewed: 22 (6 ULg)
Full Text
Peer Reviewed
See detailSoutien du niveau intermediaire au district sanitaire urbain a Kinshasa (1995-2005), RD Congo.
Kahindo Mbeva, Jean-Bosco; Schirvel, Carole; Karemere, Hermes et al

in Sante publique (Vandoeuvre-les-Nancy, France) (2012), 24 Spec No

As a result of the decentralization of health systems, some countries have introduced intermediate (provincial) levels in their public health system. This paper presents the results of a case study ... [more ▼]

As a result of the decentralization of health systems, some countries have introduced intermediate (provincial) levels in their public health system. This paper presents the results of a case study conducted in Kinshasa on health system decentralization. The study identified a shift from a focus on regulation compliance assessment to an emphasis on health system coordination and health district support. It also highlighted the emergence of a?managerial (as opposed to a bureaucratic) approach to health district support. The performance of health districts in terms of health care coverage and health service use were also found to have improved. The results highlight the importance of intermediate levels in?the health care system and the value of a more organic and managerial rationality in supporting health districts faced with the complexity of urban environments and the integration of specialized multi-partner programs and interventions. [less ▲]

Detailed reference viewed: 19 (2 ULg)
Full Text
Peer Reviewed
See detailMacroH2A1 regulates the balance between self-renewal and differentiation commitment in embryonic and adult stem cells.
Creppe, Catherine ULg; Janich, Peggy; Cantarino, Neus et al

in Molecular and cellular biology (2012), 32(8), 1442-52

One of the most striking epigenetic alterations that occurs at the level of the nucleosome is the complete exchange of the canonical H2A histones for the macroH2A variant. Here, we provide insight into ... [more ▼]

One of the most striking epigenetic alterations that occurs at the level of the nucleosome is the complete exchange of the canonical H2A histones for the macroH2A variant. Here, we provide insight into the poorly recognized function of macroH2A in transcriptional activation and demonstrate its relevance in embryonic and adult stem cells. Knockdown of macroH2A1 in mouse embryonic stem (mES) cells limited their capacity to differentiate but not their self-renewal. The loss of macroH2A1 interfered with the proper activation of differentiation genes, most of which are direct target genes of macroH2A. Additionally, macroH2A1-deficient mES cells displayed incomplete inactivation of pluripotency genes and formed defective embryoid bodies. In vivo, macroH2A1-deficient teratomas contained a massive expansion of malignant, undifferentiated carcinoma tissue. In the heterogeneous culture of primary human keratinocytes, macroH2A1 levels negatively correlated with the self-renewal capacity of the pluripotent compartment. Together these results establish macroH2A1 as a critical chromatin component that regulates the delicate balance between self-renewal and differentiation of embryonic and adult stem cells. [less ▲]

Detailed reference viewed: 4 (0 ULg)
Full Text
See detailL'ancien institut de stomatologie à Bavière en sursis
Charlier, Sébastien ULg

in Nouvelles du Patrimoine (Les) (2012), 135

Detailed reference viewed: 64 (17 ULg)
Full Text
Peer Reviewed
See detailDynamic interaction between lymphoid tyrosine phosphatase and C-terminal Src kinase controls T cell activation
Tautz, Lutz; Vang, Torkel; Liu, Wallace et al

in FASEB Journal (2012, April), 26

Lymphoid tyrosine phosphatase (LYP) and C-terminal Src kinase (CSK) are negative regulators of signaling mediated through the T cell antigen receptor (TCR) and are thought to act in a cooperative manner ... [more ▼]

Lymphoid tyrosine phosphatase (LYP) and C-terminal Src kinase (CSK) are negative regulators of signaling mediated through the T cell antigen receptor (TCR) and are thought to act in a cooperative manner when forming a complex. Here, we show that dissociation of the LYP/CSK complex is necessary for recruitment of LYP to lipid rafts, where it down-modulates TCR-mediated signaling. Our findings may also explain the reduced TCR signaling associated with a single nucleotide polymorphism, which confers increased risk for autoimmunity and results in the expression of a LYP allele that can no longer bind CSK. Development of a potent and selective chemical probe of LYP allowed us to confirm that the observed down-modulation of TCR-induced signaling was due to the LYP catalytic activity. Our compound also represents a starting point for the development of a LYP-based treatment of autoimmunity. [less ▲]

Detailed reference viewed: 37 (1 ULg)
Full Text
See detailHumidity 3D field comparisons between GNSS tomography, IASI satellite observations and ALARO model
Brenot, Hugues; Champollion, Cedric; Deckmyn, Alex et al

in Geophysical Research Abstracts (2012, April), 14

Detailed reference viewed: 91 (2 ULg)
See detailL'immersion linguistique en contexte de mobilité Erasmus
Meunier, Deborah ULg

Scientific conference (2012, April)

Detailed reference viewed: 51 (8 ULg)
Peer Reviewed
See detailAllergenic properties of the house dust mite protease Der p 3
Bouaziz, Ahlem ULg

Poster (2012, April)

Detailed reference viewed: 6 (1 ULg)
See detailGender and leadership
Cornet, Annie ULg

Speech/Talk (2012)

Detailed reference viewed: 26 (7 ULg)
Full Text
Peer Reviewed
See detailLa dissuasion. Histoire du nucléaire militaire français
Dumoulin, André ULg

in Histoire & Stratégie (2012), (10),

Detailed reference viewed: 34 (3 ULg)
Peer Reviewed
See detailLight as a modulator of cognitive brain functions
Vandewalle, Gilles ULg

Conference (2012, April)

Detailed reference viewed: 19 (1 ULg)
See detailEnsembles reconnaissables de rationnels
Charlier, Emilie ULg

Scientific conference (2012, April)

In this talk I will introduce the recognizable sets of rationals, following the formalism of Jeffrey Shallit. I will point out several open questions regarding this topic.

Detailed reference viewed: 7 (0 ULg)
Full Text
See detailThe size and book-to-market effects revisited
Lambert, Marie ULg; Hübner, Georges ULg

E-print/Working paper (2012)

Detailed reference viewed: 23 (5 ULg)
Full Text
See detailMathémagie 2
Rigo, Michel ULg

Speech/Talk (2012)

Nous présentons ici des tours de magie ne nécessitant aucune habileté particulière de la part de l'apprenti magicien : des tours de cartes, des tours de divination etc. Contrairement au magicien qui ne ... [more ▼]

Nous présentons ici des tours de magie ne nécessitant aucune habileté particulière de la part de l'apprenti magicien : des tours de cartes, des tours de divination etc. Contrairement au magicien qui ne dévoile jamais ses secrets, ici, nous expliquons que ces tours reposent sur diverses propriétés et constructions mathématiques (décomposition d'une permutation en produit de cycle, suites linéaires récurrentes, ...). Il y en aura donc pour tous les goûts... et tous les niveaux. Dans la mesure du possible, nous présenterons de "nouveaux" tours qui n'auraient pas déjà été dévoilés dans un exposé précédent. [less ▲]

Detailed reference viewed: 166 (15 ULg)
Full Text
Peer Reviewed
See detailPosture polémique ou polémisation de la posture ?
Moor, Louise ULg

in COnTEXTES : Revue de Sociologie de la Littérature (2012), 10

Detailed reference viewed: 38 (2 ULg)