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See detailTyrosine-dependent capture of CAP-Gly domain‐containing proteins in complex mixture by EB1 C-terminal peptidic probes
Calligaris, David ULg; Manatschal, Cristina; Marcellin, Marlène et al

in Journal of Proteomics (2012), 75

Microtubule dynamics is regulated by an array of microtubule associated proteins of which the microtubule plus-end tracking proteins (+TIPs) are prominent examples. +TIPs form dynamic interaction networks ... [more ▼]

Microtubule dynamics is regulated by an array of microtubule associated proteins of which the microtubule plus-end tracking proteins (+TIPs) are prominent examples. +TIPs form dynamic interaction networks at growing microtubule ends in an EB1-dependent manner. The interaction between the C-terminal domain of EB1 and the CAP-Gly domains of the +TIP CLIP-170 depends on the last tyrosine residue of EB1. In the present study, we generated peptidic probes corresponding to the C-terminal tail of EB1 to affinity-capture binding partners from cell lysates. Using an MS-based approach, we showed that the last 15 amino-acid residues of EB1, either free or immobilized on beads, bound recombinant CAP-Gly domains of CLIP-170. We further demonstrate that this binding was prevented when the C-terminal tyrosine of EB1 was absent in the peptidic probes. Western blotting in combination with a label-free quantitative proteomic analysis revealed that the peptidic probe harboring the C-terminal tyrosine of EB1 effectively pulled-down proteins with CAP-Gly domains from endothelial cell extracts. Additional proteins known to interact directly or indirectly with EB1 and the microtubule cytoskeletonwere also identified. Our peptidic probes represent valuable tools to detect changes induced in EB1-dependent +TIP networks by external cues such as growth factors and small molecules. [less ▲]

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See detailSoutien du niveau intermediaire au district sanitaire urbain a Kinshasa (1995-2005), RD Congo.
Kahindo Mbeva, Jean-Bosco; Schirvel, Carole; Karemere, Hermes et al

in Sante publique (Vandoeuvre-les-Nancy, France) (2012), 24 Spec No

As a result of the decentralization of health systems, some countries have introduced intermediate (provincial) levels in their public health system. This paper presents the results of a case study ... [more ▼]

As a result of the decentralization of health systems, some countries have introduced intermediate (provincial) levels in their public health system. This paper presents the results of a case study conducted in Kinshasa on health system decentralization. The study identified a shift from a focus on regulation compliance assessment to an emphasis on health system coordination and health district support. It also highlighted the emergence of a?managerial (as opposed to a bureaucratic) approach to health district support. The performance of health districts in terms of health care coverage and health service use were also found to have improved. The results highlight the importance of intermediate levels in?the health care system and the value of a more organic and managerial rationality in supporting health districts faced with the complexity of urban environments and the integration of specialized multi-partner programs and interventions. [less ▲]

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See detailUnderstanding of the Venus upper atmosphere dynamics with O2(a1 ) Venus Express observations
Soret, Lauriane ULg; Gérard, Jean-Claude ULg; Piccioni, Giuseppe et al

Poster (2012, April)

The O2(a1 ) nightglow emission at 1.27 m may be used as a tracer of the dynamics prevailing in the Venusian upper mesosphere. This emission has thus been observed with ground-based telescopes and from ... [more ▼]

The O2(a1 ) nightglow emission at 1.27 m may be used as a tracer of the dynamics prevailing in the Venusian upper mesosphere. This emission has thus been observed with ground-based telescopes and from space with instruments such as VIRTIS on board Venus Express. Observations have shown that the emission maximum is statistically located close to the antisolar point at 96 km. As originally suggested by Connes et al. (1979), such an emission results from the production of oxygen atoms on the Venus dayside by photodissociation and electron impact dissociation of CO2 and CO, which are then transported to the nightside by the subsolar to antisolar general circulation, where they recombine to create excited O2(a1 ) molecules. Their radiative deexcitation produces the O2(a1 ) nightglow with a maximum near the antisolar point. However, VIRTIS observations indicate that the O2(a1 ) nightglow emission is highly variable, both in intensity and location. Actually, when considering individual observations, the patch of bright emission is rarely located at the antisolar point and the brighter area around this point is the result of statics accumulation. Also, when considering several individual observations acquired in a short period of time, it is possible to follow an individual emission patch and to deduce its displacement and its brightness variation due to activation or deactivation. In this study, we analyze several sequences of VIRTIS observations in order to understand the Venus upper mesosphere dynamics.We show that the intensity can vary by several megaRayleighs in a couple of hours with effective lifetimes on the order of several hours. The horizontal motion of the spots leads to the conclusion that winds in the 95-100 km region are in the range of 25 to 150 m s-1, in good agreement with the study by Hueso et al. (2008). [less ▲]

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See detailPhysiologie, pharmacologie et modélisation de canaux potassiques : zoom sur les canaux SK
Dilly, Sébastien ULg; Poncin, Sylvie; Lamy, Cédric et al

in Medecine Sciences : M/S (2012), 28

Various types of ion channels are involved in the control of neuronal activity. Among them, SK channels represent an interesting therapeutic target. Indeed, they underlie medium duration ... [more ▼]

Various types of ion channels are involved in the control of neuronal activity. Among them, SK channels represent an interesting therapeutic target. Indeed, they underlie medium duration afterhyperpolarizations in many types of neurons, thus inhibiting cell excitability. A thorough knowledge of the physiology of these channels and the discovery of non-peptidic selective modulators able to pass the blood-brain barrier are essential in view of developing future drugs for brain diseases such as those related to a dysfunction of dopaminergic and serotonergic systems. [less ▲]

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See detailA fully nonlinear finite element model for orthodontic tooth movement prediction
Mengoni, Marlène ULg; D'Otreppe, Vinciane ULg; Ponthot, Jean-Philippe ULg

in Proceedings of the 10th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering. (2012, April)

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See detailHumidity 3D field comparisons between GNSS tomography, IASI satellite observations and ALARO model
Brenot, Hugues; Champollion, Cedric; Deckmyn, Alex et al

in Geophysical Research Abstracts (2012, April), 14

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See detailETAPE - Rapport d’évaluation des résultats
Vanmeerbeek, Marc ULg; Bednarek, Stéphanie; Lachaussée, Sophie et al

Report (2012)

Contexte et objectifs ETAPE est un programme d’intervention précoce à domicile au bénéfice de familles à risque de négligence parentale. Le programme prend en charge des enfants de 0 à 30 mois, ainsi que ... [more ▼]

Contexte et objectifs ETAPE est un programme d’intervention précoce à domicile au bénéfice de familles à risque de négligence parentale. Le programme prend en charge des enfants de 0 à 30 mois, ainsi que leurs parents, au rythme d’une à deux visites à domicile par semaine. L’intervention consiste en des massages du bébé, des jeux psychomoteurs. Un temps important est en outre consacré à l’accompagnement et à la guidance du rôle parental. L’originalité du projet est qu’il est centré sur le développement psychomoteur et affectif du bébé en lien avec son ou ses parents. L’étude cherche à mesurer l’efficacité du programme en termes de développement psychomoteur de l’enfant, de qualité d’attachement au sein de la dyade parent-enfant et de compétences éducatives des parents. Méthodologie Les aptitudes psychomotrices de l’enfant ont été mesurées au moyen du test de Brunet et Lézine modifié, au début, en milieu et en fin d’intervention. Le caractère sécure ou non de l’attachement a été mesuré chez le caregiver par Q-Sort en début et en fin d’intervention. Les compétences parentales ont été évaluées tous les six mois durant l’intervention au moyen d’un questionnaire développé par l’équipe de recherche en 2008 (MASPIN) et complété par les intervenants sur base de leurs observations. Résultats Douze enfants ont été étudiés. Les trois quarts ont été pris en charge avant 1 an ; la durée moyenne d’intervention est de 11,3 mois. En moyenne, les enfants gagnent nettement en score de développement moteur global, gagnent un peu en socialisation, sont stables en développement moteur fin. La plupart régressent au score de langage, ce qui influence négativement le score global de développement. Deux enfants sur douze sont sécures au début et à la fin de l’intervention (mais ce ne sont pas les mêmes). Aucun ne termine l’intervention significativement insécurisé, mais la relation dans la dyade n’est en général pas optimale. Les résultats de MASPIN permettent d’étoffer les autres résultats obtenus et de mieux comprendre l’évolution au cas par cas. Discussion Les résultats, mesurés par les tests de Brunet-Lézine et le Q-Sort semblent modestes dans certains domaines, mais doivent être analysés à la lumière des conditions d’intervention. MASPIN a donné une vue beaucoup plus précise de la réalité et de son évolution. Ce questionnaire a aussi permis de monitorer l’intervention. Toutefois, la finesse des observations et l’aspect subjectif de la cotation empêchent une analyse globale des résultats ; la fidélité intercotateur doit encore être validée. MASPIN permet en outre de donner des repères pour le dialogue avec d’autres professionnels impliqués dans le suivi des situations, et fournit un canevas qui facilite la discussion avec les familles sur l’exercice de la parentalité et les objectifs d’intervention. L’analyse des résultats permet de prendre conscience que certaines compétences (par ex., le langage) méritent d’être mieux soutenues et stimulées par les intervenants de terrain.) Des collaborations extérieures devront être développées (par ex : psychologue, aide sociale). L’investissement requis de la part des intervenants est important. Le risque de découragement est grand ; ils doivent être soutenus et supervisés de façon efficace dans ce travail. L’instauration d’un vrai esprit d’équipe est indispensable Conclusion Le rendement de ce programme, destiné à un public particulièrement difficile, est intéressant mais variable selon les situations prises en charge, que ce soit en termes de développement psychomoteur ou d’attachement à la figure parentale. L’outil MASPIN se révèle précieux dans de multiples aspects de la prise en charge, depuis le dialogue avec les professionnels qui identifient la situation, jusqu’au monitorage des objectifs au fil de l’intervention, en passant par la construction des objectifs d’intervention avec les parents. [less ▲]

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See detailFIRST, a high dynamic range imager, mounted on the 3-m Shane Telescope
Huby, Elsa ULg

Scientific conference (2012, April)

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See detailAllergenic properties of the house dust mite protease Der p 3
Bouaziz, Ahlem ULg

Poster (2012, April)

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See detailEffect of Transient Creep Strain Model on the Behavior of Concrete Columns Subjected to Heating and Cooling
Gernay, Thomas ULg

in Fire Technology (2012), 48(2), 313-329

In the numerical analysis of structures in fire, the material models that are used have important implications on the global behavior of the structure. In concrete, a particular phenomenon appears when ... [more ▼]

In the numerical analysis of structures in fire, the material models that are used have important implications on the global behavior of the structure. In concrete, a particular phenomenon appears when subjected to high temperatures: the transient creep strain. Models integrating explicitly a term for transient creep strain have been proposed in the literature but, in the current Eurocode 2 model, there is no explicit term for transient creep strain. This phenomenon is included in the Eurocode 2 model, but it is implicitly considered in the mechanical strain term. A series of experimental fire tests on axially restrained concrete columns subjected to heating and cooling has been recently performed at South China University of Technology and described by Wu et al. (Fire Technol 46:231–249). In the original paper, it was shown that using the implicit model of Eurocode 2, the behavior of the columns cannot be simulated properly, especially during the cooling phase. The objective of the present paper is to perform again the fire tests simulations using a new formulation of the Eurocode 2 model that contains an explicit term for transient creep. In the first part of the paper, the explicit formulation of the Eurocode 2 model is presented. In the second part, the fire tests are modeled with the software SAFIR using, on the one hand, the implicit Eurocode model and, on the other hand, the new explicit model. It is shown that the transient creep model has significant implications on the global behavior of structural concrete members, as the residual axial load sustained by the columns at the end of the fire can differ by up to 25% of the initial applied load depending on the transient creep strain model that is used for the calculation. The experimental behavior is better matched with the new explicit model than with the current Eurocode model. Particularly, the results given by the Eurocode model during the cooling phase are unconservative as the residual axial load is overestimated. Finally, it is explained why, on the basis of an example, in a performance-based approach, these results can have important implications on the global fire resistance of a structure. [less ▲]

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See detailLes querelles littéraires : esquisse méthodologique
Stienon, Valérie ULg; Saint-Amand, Denis ULg; Bertrand, Jean-Pierre ULg

in COnTEXTES : Revue de Sociologie de la Littérature (2012), 10

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See detailThe Venus nitric oxide nightglow vertical distribution : update, new features and modelling
Stiepen, Arnaud ULg; Gérard, Jean-Claude ULg; Soret, Lauriane ULg et al

Poster (2012, April)

Ultraviolet (UV) spectra of the delta (190-240 nm) and gamma (225-270 nm) bands of the nitric oxide (NO) molecule have been measured in the atmosphere of the Venus night side with the Spectroscopy for ... [more ▼]

Ultraviolet (UV) spectra of the delta (190-240 nm) and gamma (225-270 nm) bands of the nitric oxide (NO) molecule have been measured in the atmosphere of the Venus night side with the Spectroscopy for Investigation of Characteristics of the Atmosphere of Venus (SPICAV) instrument on board Venus Express (VEX). Excited NO molecules on the night side of the planet find their source in the radiative recombinaison of O(3P) and N(4S) atoms produced on the dayside by Extreme Ultraviolet (EUV) solar photons that cause photodissociation of CO2 and N2 molecules. We analyse with an improved statistics the behaviour of the vertical emission profile of the NO nightglow. We also present a method used to retrieve and analyse the volume emission rate. We describe the dependence of the vertical distribution with latitude and local time and its variability. New features in the vertical distribution of the NO emission such as double peaks are also exhibited. Furthermore, we use a one-dimensional chemical-diffusive model to compare the major features of the calculated O2 1.27 microm and NO UV emissions profiles with those observed with SPICAV. [less ▲]

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See detailEditorial
Bullens, Quentin ULg

in Carnet de Notes sur les Maltraitances Infantiles (2012), 1

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See detailL'obésité de l'enfant: Rencontre et parole donnée
Battisti, Oreste ULg

Learning material (2012)

vidéo comprenant les interviews de certaines familles confrontés à l'obésité.

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See detailPenser la querelle par la sélection naturelle. Discours et scènes romanesques du struggle for life
Stienon, Valérie ULg

in COnTEXTES : Revue de Sociologie de la Littérature (2012), 10

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See detailMathémagie 2
Rigo, Michel ULg

Speech/Talk (2012)

Nous présentons ici des tours de magie ne nécessitant aucune habileté particulière de la part de l'apprenti magicien : des tours de cartes, des tours de divination etc. Contrairement au magicien qui ne ... [more ▼]

Nous présentons ici des tours de magie ne nécessitant aucune habileté particulière de la part de l'apprenti magicien : des tours de cartes, des tours de divination etc. Contrairement au magicien qui ne dévoile jamais ses secrets, ici, nous expliquons que ces tours reposent sur diverses propriétés et constructions mathématiques (décomposition d'une permutation en produit de cycle, suites linéaires récurrentes, ...). Il y en aura donc pour tous les goûts... et tous les niveaux. Dans la mesure du possible, nous présenterons de "nouveaux" tours qui n'auraient pas déjà été dévoilés dans un exposé précédent. [less ▲]

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See detailLight as a modulator of cognitive brain functions
Vandewalle, Gilles ULg

Conference (2012, April)

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