References of "2012"
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See detailInnovative multilayered nanofibers for wound dressing application
Croisier, Florence ULg; Detrembleur, Christophe ULg; Jérôme, Christine ULg

Poster (2012, April 18)

Chitosan is a natural polymer derived from the chitin of crustacean or mushroom shells, that intrinsically presents haemostatic, mucoadhesive, antimicrobial and immunostimulant properties. This ... [more ▼]

Chitosan is a natural polymer derived from the chitin of crustacean or mushroom shells, that intrinsically presents haemostatic, mucoadhesive, antimicrobial and immunostimulant properties. This polysaccharide has shown a great potential for biomedical and pharmaceutical applications, on account of its remarkable compatibility with physiological medium. Besides, it is degraded in a physiological environment into non-toxic products, which make chitosan an outstanding candidate for short- to medium-term applications. In this respect, nanometric fibers are highly interesting as their assembly mimics the skin extracellular matrix structure. Such nanofibrous materials can be prepared by electrospinning (ESP). This technique uses a high voltage to create an electrically charged jet of polymer solution or melt which leads to fibers formation. Depending on the polymer characteristics (a.o. molecular weight, solution viscosity and conductivity) and processing conditions (electric potential, distance between syringe-capillary and collection plate, concentration, flow rate), polymer fibers ranging from nanometers to a few microns in diameter can be obtained and subsequently used as potential scaffolds, a.o. to form a temporary, artificial extracellular matrix. In the present study, electrospinning technique was combined with layer-by-layer deposition method (LBL) - a well-known method for surface coating, based on electrostatic interactions - in order to prepare multilayered chitosan-based nanofibers. The antibacterial properties of the obtained material were then assessed, and the presence of a multilayered deposit was confirmed by several techniques. (Future) possibilities for valorization: These multilayered chitosan-based nanofibers present great prospects for the preparation of new biomedical scaffolds - such as wound dressings that could improve skin regeneration. [less ▲]

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See detailWhat is new in anemia treatment in CKD since 2010?
Krzesinski, Jean-Marie ULg

Conference (2012, April 18)

•Partial correction (Hb in the range of 10-11.5 g/dL) of CKD-related anemia appears a safer strategy during the last 5y. So recommendation is to start ESA only when Hb <10 and to avoid too high ESA dose ... [more ▼]

•Partial correction (Hb in the range of 10-11.5 g/dL) of CKD-related anemia appears a safer strategy during the last 5y. So recommendation is to start ESA only when Hb <10 and to avoid too high ESA dose (CE DOSE study ongoing in HD)! •Identify resistant patients and try to improve it. •Importance of adequate iron management and of hepcidin role in the all-mortality risk in CKD. Newer strategies for correcting anemia are currently explored [less ▲]

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See detailClinicopathologic significance of DNA methyltransferase 1, 3a, and 3b overexpression in Tunisian breast cancers.
Ben Gacem, Riadh; Hachana, Mohamed Ridha ULg; Ziadi, Sonia et al

in Human Pathology (2012)

DNA methyltransferase 1, 3a, and 3b affect DNA methylation, and it is thought that they play an important role in the malignant transformation of various cancers. The current study was designed to analyze ... [more ▼]

DNA methyltransferase 1, 3a, and 3b affect DNA methylation, and it is thought that they play an important role in the malignant transformation of various cancers. The current study was designed to analyze DNA methyltransferase expression by immunohistochemistry in a series of 94 Tunisian sporadic breast carcinomas. Results were correlated to clinicopathologic parameters and promoter methylation status of 8 tumor suppressor genes (BRCA1, BRCA2, RASSFA1, TIMP3, CDH1, P16, RARβ2, and DAPK). Overexpression of DNA methyltransferase 1, 3a, and 3b was detected in 46.8%, 32%, and 44.7% of cases, respectively. A significant correlation was found between DNA methyltransferase 1 overexpression and Scarff-Bloom-Richardson histologic grade III (P = .01). DNA methyltransferase 3a overexpression was significantly associated with menopausal status (P = .01), Scarff-Bloom-Richardson histologic grade III (P = .0001), estrogen (P = .04) and progesterone (P = .007) receptor negativity, and HER2 overexpression (P = .004). However, DNA methyltransferase 3a overexpression was found less frequently in the luminal A intrinsic breast cancer subtype (9.7%) than in luminal B (53%), HER2 (41%), and triple-negative (50%) subtypes (P = .001). DNA methyltransferase 3b overexpression shows significant correlation with promoter hypermethylation of BRCA1 (P = .03) and RASSFA1 (P = .04) and with the hypermethylator phenotype (more than 4 methylated genes, P = .01). These data suggest that overexpression of various DNA methyltransferases might represent a critical event responsible for the epigenetic inactivation of multiple tumor suppressor genes, leading to the development of aggressive forms of sporadic breast cancer. [less ▲]

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See detailPhysical Fitness and Mitochondrial Respiratory Capacity in Horse Skeletal Muscle
Votion, Dominique ULg; Gnaiger, Erich; Lemieux, Hélène et al

in PLoS ONE (2012), 7(4), 1-12

We applied high-resolution respirometry and multiple substrate-uncoupler-inhibitor titration protocols to study mitochondrial physiology in small (1.0–2.5 mg) permeabilized muscle fibres sampled from ... [more ▼]

We applied high-resolution respirometry and multiple substrate-uncoupler-inhibitor titration protocols to study mitochondrial physiology in small (1.0–2.5 mg) permeabilized muscle fibres sampled from triceps brachii of healthy horses. The present investigation on horse skeletal muscle has tested the methodology used to study mitochondrial function in muscle microbiopsies by high-resolution respirometry to define reference protocols for horses (from sampling procedure to data analysis). [less ▲]

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See detail1-84 PTH and KDIGO Guidelines
CAVALIER, Etienne ULg

Conference (2012, April 18)

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See detailMaterial Aspects of Bone Tissue Engineering
Ozhukil Kollath, Vinayaraj ULg; Cloots, Rudi ULg

Diverse speeche and writing (2012)

Bone tissue engineering is a highly studied topic in material science in the recent decades. Basic principles of chemistry and biology along with advanced material science techniques should be used in ... [more ▼]

Bone tissue engineering is a highly studied topic in material science in the recent decades. Basic principles of chemistry and biology along with advanced material science techniques should be used in order to elucidate the parameters which may influence the bone tissue growth on artificial implants. Progress has been made to an advanced level but still there is room for improvements. Especially in case of large bone defects, finding a ‘universal’ replacement implant is difficult. Patient specific data have to be taken in to account to get a good osteointegration. Metal and ceramic implants are commonly tested in case of large bone defects, but a good mimic of natural bone is hard due to various reasons. However fine tuning these materials and combination of these materials are finding good results. Addition of polymer materials in such implants is a recent effective attempt. Different combinations of these materials along with functionalisation using bioactive molecules make the bone tissue engineering nearly perfect. This presentation will discuss about the recent trends in the materials used in bone tissue engineering. [less ▲]

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See detail"Enjeux et défis de l'enseignement des langues dans le contexte de la mondialisation"
Defays, Jean-Marc ULg; Maréchal, Marielle ULg; Louis, Vincent

Scientific conference (2012, April 17)

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See detailMethod for manufacturing a junction
Nguyen, Ngoc Duy ULg; Loo, Roger; Caymax, Matty

Patent (2012)

The present invention relates to a semiconductor device comprising a homojunction or a heterojunction with a controlled dopant (concentration) profile and a method of making the same. Accordingly, one ... [more ▼]

The present invention relates to a semiconductor device comprising a homojunction or a heterojunction with a controlled dopant (concentration) profile and a method of making the same. Accordingly, one aspect of the invention is a method for manufacturing a junction comprising forming a first semiconductor material comprising a first dopant having a first concentration and thereupon forming a second semiconductor material comprising a second dopant, having a second concentration thereby forming a junction, and depositing by Atomic Layer Epitaxy or Vapor Phase Doping at least a fraction of a monolayer of a precursor suitable to form the second dopant on the first semiconductor material, prior to forming the second semiconductor material, thereby increasing the second concentration of the second dopant at the junction. [less ▲]

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See detailAnémies et insuffisance rénale : quoi de neuf?
Krzesinski, Jean-Marie ULg

Conference (2012, April 17)

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See detailPerturbateurs endocriniens à effet réprotoxique
Charlier, Corinne ULg

Scientific conference (2012, April 17)

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See detailEtudes des systèmes de défenses antitoxiques chez l’amphipode Gammarus roeseli : Effets du parasitisme et d’une exposition au cadmium.
Gismondi, Eric ULg

Doctoral thesis (2012)

Pour faire face à des perturbations environnementales, les organismes ont développé des défenses antitoxiques couramment utilisés comme biomarqueurs dans l’évaluation de la qualité des milieux. Cependant ... [more ▼]

Pour faire face à des perturbations environnementales, les organismes ont développé des défenses antitoxiques couramment utilisés comme biomarqueurs dans l’évaluation de la qualité des milieux. Cependant, de nombreux facteurs confondants comme la température ou le genre, influencent la réponse de ces biomarqueurs. Il est ainsi nécessaire de connaitre les effets de ces facteurs afin d’imputer correctement la réponse biologique mesurée à la présence de polluants. Dans ce contexte, nous avons choisi d’étudier l’influence d’un parasite acanthocéphale, Polymorphus minutus, transmis horizontalement et de microsporidies à transmission verticale, sur les réponses physiologiques de leur hôte, Gammarus roeseli, un crustacé amphipode d’eau douce d’intérêt écotoxicologique. Pour cela, nous avons choisi d’étudier le glutathion, tripeptide jouant un rôle central dans les systèmes antitoxiques, sa synthèse (i.e. activité γ-glutamylcystéine ligase), les réserves énergétiques (i.e. lipides, glycogène, protéines) et un biomarqueur d’effets toxiques, le malondialdéhyde. L’influence du parasitisme a été appréhendé dans différents cas d’études: (i) chez G. roeseli infecté par P. minutus, (ii) chez G. roeseli infecté par des microsporidies (Dictyocoela roeselum essentiellement) et (iii) chez G. roeseli co-infecté par ces deux types de parasite. Chaque cas d’étude a été réalisé en absence de stress et lors d’une exposition au cadmium. Nous avons mis en évidence qu’en absence de contamination, la présence de P. minutus et une co-infection par P. minutus et D. roeselum affectent les biomarqueurs de G. roeseli. Après exposition au cadmium, la présence de parasites (i.e. infection simple ou co-infection) modifie la mobilisation des défenses antitoxiques et accentue les effets toxiques subits par l’hôte. Les résultats obtenus au cours de ce travail mettent en avant le caractère confondant du parasitisme en écotoxicologie et souligne l’importance de prendre en compte ce paramètre lors de l’évaluation de la qualité des milieux. [less ▲]

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See detailConstruire son langage, une nouvelle conception de l’acquisition langagière: données développementales et approche en pathologie langagière
Leroy, Sandrine ULg; Maillart, Christelle ULg

Scientific conference (2012, April 17)

Cette conférence traite des répercussions sur notre pratique logopédique d’une nouvelle conception du développement langagier. Celle-ci s’intéresse à la construction du langage oral chez l’enfant. Elle ... [more ▼]

Cette conférence traite des répercussions sur notre pratique logopédique d’une nouvelle conception du développement langagier. Celle-ci s’intéresse à la construction du langage oral chez l’enfant. Elle considère que l’enfant est l’acteur de son développement langagier ; il construit progressivement son langage à partir de ses propres productions antérieures. Cette nouvelle conception issue de la linguistique cognitivo-fonctionnelle s’oppose donc à la conception innéiste (ou générativiste) qui considère que l’enfant dispose de connaissances langagières innées. Cette approche constructiviste nous offre des perspectives théoriques et thérapeutiques très intéressantes pour étudier la pathologie langagière. Des données récentes récoltées auprès d’enfants tout-venant sont présentées. Par la suite, nous abordons plus spécifiquement la dysphasie. Nous tentons de comprendre comment ces théories permettent d'expliquer les difficultés langagières des enfants dysphasiques. Enfin, nous envisageons quels sont les éléments dont il faut tenir compte dans notre pratique logopédique, à la lumière de cette nouvelle conception développementale. [less ▲]

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See detailCarrier and aberrations removal in interferometric fringe projection profilometry
Blain, Pascal ULg; Michel, Fabrice; Renotte, Yvon ULg et al

in Gorecki, Christophe; Asundi, Anand K.; Osten, Wolfgang (Eds.) Optical Micro- and Nanometrology IV (SPIE proceedings vol.8430) (2012, April 17)

A profilometer which takes advantage of polarization states splitting technique and monochromatic light projection method as a way to overcome ambient lighting for in-situ measurement is under development ... [more ▼]

A profilometer which takes advantage of polarization states splitting technique and monochromatic light projection method as a way to overcome ambient lighting for in-situ measurement is under development [1, 2]. Because of the Savart plate which refracts two out of axis beams, the device suffers from aberrations (mostly coma and astigmatism). These aberrations affect the quality of the sinusoidal fringe pattern. In fringe projection profilometry, the unwrapped phase distribution map contains the sum of the object’s shape-related phase and carrier-fringe-related phase. In order to extract the 3D shape of the object, the carrier phase has to be removed [3, 4]. An easy way to remove both the fringe carrier and the aberrations of the optical system is to measure the phases of the test object and to measure the phase of a reference plane with the same set up and to subtract both phase maps. This time consuming technique is suitable for laboratory but not for industry. We propose a method to numerically remove both the fringe carrier and the aberrations. A first reference phase of a calibration plane is evaluated knowing the position of the different elements in the set up and the orientation of the fringes. Then a fitting of the phase map by Zernike polynomials is computed [5]. As the triangulation parameters are known during the calibration, the computation of Zernike coefficients has only to be made once. The wavefront error can be adjusted by a scale factor which depends on the position of the test object. [less ▲]

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See detailNon-conventional Political Participation as an outcome of Discrimination Feeling
Gavray, Claire ULg; Born, Michel ULg

Scientific conference (2012, April 17)

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See detailHistoire d'un ElDorado - Cinq siècles d'exploration du sous-sol sud-américain
Pirard, Eric ULg

Scientific conference (2012, April 17)

Une présentation du rapport de l'Amérique Latine au richesses de son sous-sol, depuis la découverte de l'Amérique jusqu'à aujourd'hui.

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See detailRaman spectroscopy, a tool for biochemical applications
Malherbe, Cédric ULg

Scientific conference (2012, April 17)

Detailed reference viewed: 16 (8 ULg)