References of "2012"
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See detailDu théâtre magique au cinéma fantastique : les figures extatiques de Georges Méliès
Tomasovic, Dick ULg

in Gimello-Mesplomb, Frédéric (Ed.) Le Cinéma fantastique français à l’épreuve du genre fantastique. Socioanalyse d’une production artistique (2012)

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See detailExpression of specific pathways in the inflamed synovial membrane of osteoarthritis patient: Identification of new potential key intermediates
Lambert, Cécile ULg; Dubuc, Jean-Emile; Hennuy, Benoît ULg et al

in Osteoarthritis and Cartilage (2012, April), 20(Supplement 1), 56

Purpose: Synovitis is a key factor in osteoarthritis (OA) pathophysiology, contributing to both patient symptoms and disease progression. In this study, using an original methodology comparing normal ... [more ▼]

Purpose: Synovitis is a key factor in osteoarthritis (OA) pathophysiology, contributing to both patient symptoms and disease progression. In this study, using an original methodology comparing normal/reactive (N/R) and inflammatory (I) synovial membranes zones, we investigated the gene expression profiles of synovial cells from these areas and identified differentially regulated pathways. <br />Methods: Synovial cells (SC) were isolated from OA synovial specimens obtained from 12 patients undergoing knee replacement. The inflammatory status of the synovial membrane was characterized by the surgeon according to macroscopic criteria including the synovial vascularization, the villi formation and the hypertrophic aspect of the tissue. At the surgery time, the synovial membrane was dissected and biopsies from N/R and I areas cultured separately for a period of 7 days. Total RNA was extracted using the RNeasy Mini Kit. RNA purity and quality were evaluated using the Experion RNA StdSens Analysis kit (Bio-rad Laboratories). Gene expression profiling between N/R and I areas was performed using Illumina’s multi-sample format Human HT-12 BeadChip (Illumina Inc.). Differential analysis was performed with the BRB array tools software. Class Comparison test between N/R and I areas was based on paired t-test where N/R and I were paired for each patient. The biological relevance of up- and down-regulated genes was analyses with Ingenuity Pathways Analysis (Ingenuity® Systems). Western blot was performed to confirm certain intermediate expression. <br />Results: From among 47000 probes, 17500 were filtered out. Probes with a p-value below than 0.005 were chosen and classified as up- or down-regulated ones. By this way, 896 differentially expressed genes between N/R and I zones were identified. Among these, 576 genes were upregulated (I/NR > 1.5) and 320 downregulated (I/NR < 0.75). With Ingenuity Pathways Analysis, a significant number of the top ranking differentially expressed genes were identified as inflammatory, Wnt and angiogenic pathways. Interleukin (IL)-6 and -8, chemokines (CXCL1, CXCL2, CXCL5, CXCL6, CXCL16) and arachidonate 5-lipoxygenase (ALOX5) were identified as the most upregulated in I zones in the inflammatory pathway. Interestingly, the alarmin S100A9 was found strongly upregulated in this pathway. Wnt5A and LRP (Low density lipoprotein receptor-related protein) 5 were upregulated whereas FZD (Frizzled homolog) 2 and DKK (dickkopf homolog) 3 were downregulated in the Wnt signaling pathway. Finally, stanniocalcin (STC)-1, an intermediate in angiogenesis was identified as the most upregulated gene in I zones compared to N/R zones. This difference of expression was confirmed at the protein level. <br />Conclusions: Using a unique culture system, this study is the first to identify different expression pattern between two areas of synovial membrane from the same OA patient. These differences concern several key pathways involved in OA pathogenesis, i.e. inflammation, Wnt and angiogenesis. This analysis also provided interesting information regarding new potent intermediates as S100A9 and STC-1. They could be potential targets for chondroitin sulfate, one of the most used molecules in the management of OA. New experiments are being perfomed at the moment to elucidate the potential effect of this molecule on these specific differentially expressed genes in the same culture system. [less ▲]

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See detailDamping identification of lightly damped linear dynamic systems using Common-base Proper Orthogonal Decomposition
Andrianne, Thomas ULg; Dimitriadis, Grigorios ULg

in Mechanical Systems & Signal Processing (2012), 28

This paper presents a new technique to identify the damping of linear systems. It is developed from the Proper Orthogonal Decomposition (POD) of the free response of the system and extended to the ... [more ▼]

This paper presents a new technique to identify the damping of linear systems. It is developed from the Proper Orthogonal Decomposition (POD) of the free response of the system and extended to the recently proposed Common-base POD (CPOD). The present application of CPOD considers simultaneously several free responses of the system to different initial conditions. The eigen-decomposition of the co-variance matrix leads to a unique vector basis which is likely to contain more information about the dynamics of the system than a vector basis obtained by the classic POD technique. The ability of the technique to estimate the mode shapes and the modal damping is demonstrated on a simulated mass-spring-damper system. Two different distributions of masses are considered in order to confront the CPOD analysis to the intrinsic limitation of POD, i.e. that the mode shapes are identified exactly only if the mass matrix is proportional to the identity matrix. It is shown that the identification of the damping is still possible when the modes are not orthonormal. The robustness of the technique is demonstrated in the presence of noise in the responses of the system and through an experimental application with comparison with other identifications techniques. [less ▲]

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See detailDynamic interaction between lymphoid tyrosine phosphatase and C-terminal Src kinase controls T cell activation
Tautz, Lutz; Vang, Torkel; Liu, Wallace et al

in FASEB Journal (2012, April), 26

Lymphoid tyrosine phosphatase (LYP) and C-terminal Src kinase (CSK) are negative regulators of signaling mediated through the T cell antigen receptor (TCR) and are thought to act in a cooperative manner ... [more ▼]

Lymphoid tyrosine phosphatase (LYP) and C-terminal Src kinase (CSK) are negative regulators of signaling mediated through the T cell antigen receptor (TCR) and are thought to act in a cooperative manner when forming a complex. Here, we show that dissociation of the LYP/CSK complex is necessary for recruitment of LYP to lipid rafts, where it down-modulates TCR-mediated signaling. Our findings may also explain the reduced TCR signaling associated with a single nucleotide polymorphism, which confers increased risk for autoimmunity and results in the expression of a LYP allele that can no longer bind CSK. Development of a potent and selective chemical probe of LYP allowed us to confirm that the observed down-modulation of TCR-induced signaling was due to the LYP catalytic activity. Our compound also represents a starting point for the development of a LYP-based treatment of autoimmunity. [less ▲]

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See detailHow does elicitor and antimicrobial fengycin interact with plasma membranes of sensitive cells ?
Nasir, Mehmet Nail ULg; Eeman, Marc; Lins, Laurence ULg et al

Conference (2012, April)

Fengycin is characterized by its strong antifungal and low hemolytic activities. It has also been recently demonstrated that it has plant elicitor properties and is also able to enhance the elicitors’ ... [more ▼]

Fengycin is characterized by its strong antifungal and low hemolytic activities. It has also been recently demonstrated that it has plant elicitor properties and is also able to enhance the elicitors’ activity of surfactin. The cell target of its biological activities is supposed to be plasma membrane. In spite of these interesting biological activities, fengycin has not been extensively investigated probably because of the difficulties related to its production. In a first time; we have characterized the interfacial properties of fengycin by tensiometry measurements and demonstrated that this surface activity was pH-dependent. In a second time; we have investigated the interactions of the lipopeptide with membrane lipids using model membranes such as Langmuir monolayers and multilammelar vesicles (MLVs). Our results indicate that the lipopeptide was able to penetrate into different lipid monolayers showing a preference for sterol-containing monolayers. In order to better understand the mechanism of the interactions of fengycin with membranes at the molecular level, MLVs with or without fengycin have been analyzed by spectroscopic techniques. We have shown that conformational changes of the lipopeptide occurred in the presence of lipids and they were more significant in the presence of sterol. Moreover, tyrosine residues of the lipopeptide seem to play an important role in these interactions. In conclusion, we have determined that the surface-active behavior as well as the conformation of fengycin depends on its environment. We have also showed that the lipopeptide does not interact with all class of lipids in the same way and presents a preference for sterols. The presence of key groups within peptide cycle has also been supposed for the biological activities of the lipopeptide. [less ▲]

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See detailCarnet de pédiatrie en Afrique: Démonstration de la prise-en-charge du nouveau-né
Battisti, Oreste ULg; Académie américaine de pédiatrie

Learning material (2012)

video reprenant les gestes de prise-en-charge du nouveau-né en salle d'accouchement

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See detailRéponses du Martin-pêcheur huppé Alcedo cristata à la perturbation de ses sites de nidification
Kisasa Kafutshi, Robert ULg

in Malimbus (2012), 34(28-38),

From 2004 to 2009, two colonies of Malachite Kingfisher were monitored by ringing the nestlings and adults, counting eggs and observing parental activity at the nests. Results show that 10 % of nests were ... [more ▼]

From 2004 to 2009, two colonies of Malachite Kingfisher were monitored by ringing the nestlings and adults, counting eggs and observing parental activity at the nests. Results show that 10 % of nests were destroyed by people in the Symphonies site as against 78 % in the Monastery site. Consequently, the number of nests available for breeding is lower at Monastery than at Symphonies. The number of fledged chicks per nest at Symphonies was twice that at the Monastery. Site fidelity is higher for the adults in the Symphonies site (26 %) than at the Monastery (11 %). This suggests that the Monastery site is less favourable to the survival of the Malachite Kingfisher than the Symphonies site. The best strategy to protect this species seems to be the maintenance of a good number of nesting sites. [less ▲]

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See detailImaginaires de la vie littéraire. Fiction, figuration, configuration
Dozo, Björn-Olav ULg; Glinoer, Anthony; Lacroix, Michel

Book published by Presses universitaires de Rennes (2012)

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See detailEffect of Transient Creep Strain Model on the Behavior of Concrete Columns Subjected to Heating and Cooling
Gernay, Thomas ULg

in Fire Technology (2012), 48(2), 313-329

In the numerical analysis of structures in fire, the material models that are used have important implications on the global behavior of the structure. In concrete, a particular phenomenon appears when ... [more ▼]

In the numerical analysis of structures in fire, the material models that are used have important implications on the global behavior of the structure. In concrete, a particular phenomenon appears when subjected to high temperatures: the transient creep strain. Models integrating explicitly a term for transient creep strain have been proposed in the literature but, in the current Eurocode 2 model, there is no explicit term for transient creep strain. This phenomenon is included in the Eurocode 2 model, but it is implicitly considered in the mechanical strain term. A series of experimental fire tests on axially restrained concrete columns subjected to heating and cooling has been recently performed at South China University of Technology and described by Wu et al. (Fire Technol 46:231–249). In the original paper, it was shown that using the implicit model of Eurocode 2, the behavior of the columns cannot be simulated properly, especially during the cooling phase. The objective of the present paper is to perform again the fire tests simulations using a new formulation of the Eurocode 2 model that contains an explicit term for transient creep. In the first part of the paper, the explicit formulation of the Eurocode 2 model is presented. In the second part, the fire tests are modeled with the software SAFIR using, on the one hand, the implicit Eurocode model and, on the other hand, the new explicit model. It is shown that the transient creep model has significant implications on the global behavior of structural concrete members, as the residual axial load sustained by the columns at the end of the fire can differ by up to 25% of the initial applied load depending on the transient creep strain model that is used for the calculation. The experimental behavior is better matched with the new explicit model than with the current Eurocode model. Particularly, the results given by the Eurocode model during the cooling phase are unconservative as the residual axial load is overestimated. Finally, it is explained why, on the basis of an example, in a performance-based approach, these results can have important implications on the global fire resistance of a structure. [less ▲]

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See detailAn adaptive thermal comfort model for hot humid South-East Asia
Nguyen, Anh Tuan ULg; Singh, Manoj Kumar ULg; Reiter, Sigrid ULg

in Building & Environment (2012), 56

The present paper presents a full procedure to develop an adaptive comfort model for South-East Asia. Meta-analysis on large number of observations from field surveys which were conducted in this region ... [more ▼]

The present paper presents a full procedure to develop an adaptive comfort model for South-East Asia. Meta-analysis on large number of observations from field surveys which were conducted in this region was employed. Standardization and bias control of the database were fully reported. Statistical tests of significance and weighted regression method applied in the analyses strengthened the reliability of the findings. This paper found a great influence of ‘Griffiths constant’ on the establishment of adaptive comfort equation and proposed an appropriate value. The adaptive comfort model generated is applicable to naturally ventilated building under hot and humid conditions of South-East Asia. The mean neutral comfort temperature (operative temperature, effective temperature, standard effective temperature) in naturally ventilated and air-conditioned building was compared and the differences have been discussed. The similar neutral standard effective temperature in both naturally ventilated and air-conditioned building proposes a new idea to implement SET* into building simulation tools to assess thermal comfort without the attention of building classification. Through the analysis, the effectiveness of behavioral adaptive actions on occupant’s thermal perception has been argued. The extended PMV-PPD model for hot humid conditions was examined and its applicability was recommended. Other comfort related issues, the differences and similarities between various adaptive comfort models were also addressed. [less ▲]

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See detailLes polémiques autour de la littérature jeunesse, ou la quête sans cesse rejouée de la légitimité
Barnabé, Fanny ULg

in COnTEXTES : Revue de Sociologie de la Littérature (2012), (10),

Cet article analyse les enjeux dissimulés derrière une polémique qui a débuté suite à un article de François Busnel, publié le 24 novembre 2010 dans l’Express-Lire, dans lequel ce dernier dénigre la ... [more ▼]

Cet article analyse les enjeux dissimulés derrière une polémique qui a débuté suite à un article de François Busnel, publié le 24 novembre 2010 dans l’Express-Lire, dans lequel ce dernier dénigre la littérature jeunesse et l’accuse de n’être qu’un "coup marketing". Cette publication a déclenché de nombreuses réactions chez les représentants de ce secteur. L'analyse proposée ici tâche de rendre compte, en confrontant les deux types de prises de parole, de l’impact que peut avoir l’objet d'une polémique (la littérature jeunesse, dans ce cas-ci) sur le déroulement de celle-ci. [less ▲]

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See detailLong-term magnetic field monitoring of the Sun-like star \xi Bootis A
Morgenthaler, A.; Petit, P.; Saar, S. et al

in Astronomy and Astrophysics (2012), 540

Aims: We aim to investigate the long-term temporal evolution of the magnetic field of the solar-type star ξ Bootis A, both from direct magnetic field measurements and from the simultaneous estimate of ... [more ▼]

Aims: We aim to investigate the long-term temporal evolution of the magnetic field of the solar-type star ξ Bootis A, both from direct magnetic field measurements and from the simultaneous estimate of indirect activity indicators. Methods: We obtained seven epochs of high-resolution, circularly-polarized spectra from the NARVAL spectropolarimeter between 2007 and 2011, for a total of 76 spectra. Using approximately 6100 photospheric spectral lines covering the visible domain, we employed a cross-correlation procedure to compute a mean polarized line profile from each spectrum. The large-scale photospheric magnetic field of the star was then modelled by means of Zeeman-Doppler Imaging, allowing us to follow the year-to-year evolution of the reconstructed magnetic topology. Simultaneously, we monitored the width of several magnetically sensitive spectral lines, the radial velocity, the line asymmetry of intensity line profiles, and the chromospheric emission in the cores of the Ca II H and Hα lines. Results: During the highest observed activity states, in 2007 and 2011, the large-scale field of ξ Bootis A is almost completely axisymmetric and is dominated by its toroidal component. The toroidal component persists with a constant polarity, containing a significant fraction of the magnetic energy of the large-scale surface field through all observing epochs. The magnetic topologies reconstructed for these activity maxima are very similar, suggesting a form of short cyclicity in the large-scale field distribution. The mean unsigned large-scale magnetic flux derived from the magnetic maps varies by a factor of about 2 between the lowest and highest observed magnetic states. The chromospheric flux is less affected and varies by a factor of 1.2. Correlated temporal evolution, due to both rotational modulation and seasonal variability, is observed between the Ca II emission, the Hα emission and the width of magnetically sensitive lines. The rotational dependence of polarimetric magnetic measurements displays a weak correlation with other activity proxies, presumably due to the different spatial scales and centre-to-limb darkening associated with polarimetric signatures, as compared to non-polarized activity indicators. Better agreement is observed on the longer term. When measurable, the differential rotation reveals a strong latitudinal shear in excess of 0.2 rad d-1. [less ▲]

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See detailL'invité du mois : Jean-François Husson, secrétaire général du CRAIG (Centre de Recherche en Action publique, Intégration et Gouvernance)
Depret, Alain; Husson, Jean-François ULg

Article for general public (2012)

Interview accordée au périodique de l'Union des Villes et Communes de Wallonie sur les activités du CRAIG et sur plusieurs de mes sujets de recherche : finances locales, gouvernance locale, financement ... [more ▼]

Interview accordée au périodique de l'Union des Villes et Communes de Wallonie sur les activités du CRAIG et sur plusieurs de mes sujets de recherche : finances locales, gouvernance locale, financement des cultes. [less ▲]

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See detailHigher-Moment Risk Exposures in Hedge Funds
Lambert, Marie ULg; Hübner, Georges ULg; Papageorgiou, Nicolas

Conference (2012, April)

The paper singles out the key roles of US equity skewness and kurtosis in the determination of the market premia embedded in Hedge Fund returns. We propose a conditional higher-moment asset pricing model ... [more ▼]

The paper singles out the key roles of US equity skewness and kurtosis in the determination of the market premia embedded in Hedge Fund returns. We propose a conditional higher-moment asset pricing model with location, trading and higher-moment factors in order to describe the dynamics of the Equity Hedge (Market Neutral, Short Selling and Long/Short strategies), Event Driven, Relative Value, and Funds of Hedge Funds styles. The volatility, skewness and kurtosis implied in the US options markets are used by Hedge Fund managers as instruments to anticipate market movements. Managers should adjust their market exposure in response to variations in the implied higher moments. We show that higher-moment premia improve a conditional asset pricing model both in terms of explanatory power (R-squares and Schwarz criterion) and specification errors across all Hedge Fund styles. [less ▲]

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See detailInfluence of drying and hydrothermal treatment of corn on the denaturation of salt-soluble proteins and color parameters
Odjo, Sylvanus; Malumba Kamba, Paul ULg; Dossou, Joseph et al

in Journal of Food Engineering (2012), 109(3), 561-570

The effect of heat treatments (drying and hydrothermal treatment) on the extractability of salt-soluble protein (SSP) was assessed using Promatest methodology for corn kernels heated between 60 C and 120 ... [more ▼]

The effect of heat treatments (drying and hydrothermal treatment) on the extractability of salt-soluble protein (SSP) was assessed using Promatest methodology for corn kernels heated between 60 C and 120 C. During drying, the evolution of the grain moisture content is fitted using the analytical solution of Fick equation developed by Crank (1979) for spherical material. The decrease of extractible salt-soluble protein during heating is forecasted using a first and a second order ordinary differential equation. It was found that temperature; moisture content and time of processing greatly influence the kinetic denaturation of SSP of corn kernels. The evolution of extractible SSP content of corn kernels during drying at high temperature is more correctly described with second order kinetic than with the first order kinetic reaction. The Hunterlab color parameters of corn also vary during drying. Lightness and color intensity decrease while yellowness, redness, chroma and hue angle increase through drying time. Most of these Hunterlab color parameters are highly correlated with the salt-soluble proteins content and therefore could be used as indicators of excessive heat treatment and denaturation of salt-soluble proteins in corn kernels [less ▲]

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See detailToward a Risk Based Simulation for the Erection of an Offshore Windmill Park
Caprace, Jean-David ULg; Petcu, Cristian ULg; Velarde, Marco et al

in Proceeding of the 11th International Conference on Computer Applications and Information Technology in the Maritime Industries (2012, April)

Nowadays, EU shipyards that are facing difficulties due to the global crisis are often trying to diversify their activities. Some of them have already turned to the production of offshore windmill ... [more ▼]

Nowadays, EU shipyards that are facing difficulties due to the global crisis are often trying to diversify their activities. Some of them have already turned to the production of offshore windmill components. The installation and operation of offshore windmills are much more complex than onshore due to the distance and the depth of the water column. This creates problems specific to the production, installation and maintenance of offshore wind turbines. A tool for sequencing and installation simulation has been developed to assess the risks associated to the assembly of wind turbines parks via simulations of the different phases of construction considering various random phenomena such as weather conditions and uncertainties on production time. [less ▲]

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See detailUnderstanding of the Venus upper atmosphere dynamics with O2(a1 ) Venus Express observations
Soret, Lauriane ULg; Gérard, Jean-Claude ULg; Piccioni, Giuseppe et al

Poster (2012, April)

The O2(a1 ) nightglow emission at 1.27 m may be used as a tracer of the dynamics prevailing in the Venusian upper mesosphere. This emission has thus been observed with ground-based telescopes and from ... [more ▼]

The O2(a1 ) nightglow emission at 1.27 m may be used as a tracer of the dynamics prevailing in the Venusian upper mesosphere. This emission has thus been observed with ground-based telescopes and from space with instruments such as VIRTIS on board Venus Express. Observations have shown that the emission maximum is statistically located close to the antisolar point at 96 km. As originally suggested by Connes et al. (1979), such an emission results from the production of oxygen atoms on the Venus dayside by photodissociation and electron impact dissociation of CO2 and CO, which are then transported to the nightside by the subsolar to antisolar general circulation, where they recombine to create excited O2(a1 ) molecules. Their radiative deexcitation produces the O2(a1 ) nightglow with a maximum near the antisolar point. However, VIRTIS observations indicate that the O2(a1 ) nightglow emission is highly variable, both in intensity and location. Actually, when considering individual observations, the patch of bright emission is rarely located at the antisolar point and the brighter area around this point is the result of statics accumulation. Also, when considering several individual observations acquired in a short period of time, it is possible to follow an individual emission patch and to deduce its displacement and its brightness variation due to activation or deactivation. In this study, we analyze several sequences of VIRTIS observations in order to understand the Venus upper mesosphere dynamics.We show that the intensity can vary by several megaRayleighs in a couple of hours with effective lifetimes on the order of several hours. The horizontal motion of the spots leads to the conclusion that winds in the 95-100 km region are in the range of 25 to 150 m s-1, in good agreement with the study by Hueso et al. (2008). [less ▲]

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See detailLes régimes matrimoniaux en droit international privé - autour de trois questions d'actualité
Wautelet, Patrick ULg

in Revue Droit International Privé = Tijdschrift voor Internationaal Privaatrecht (2012), 11(1), 29-43

Ce papier fait le point sur trois questions d'actualité dans la pratique du droit international privé des régimes matrimoniaux. Ces questions ont été sélectionnées parce qu'elles peuvent également se ... [more ▼]

Ce papier fait le point sur trois questions d'actualité dans la pratique du droit international privé des régimes matrimoniaux. Ces questions ont été sélectionnées parce qu'elles peuvent également se poser dans d'autres domaines du droit international privé : il s'agit d'abord de la distinction entre questions de forme et questions de fond, ensuite de l'appréhension et du fonctionnement des règles de rattachement fondée sur une échelle de rattachement et enfin de l'application concrète de l'exception d'ordre public [less ▲]

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