Showing results 181 to 200 of 7402
  Les éco-quartiers : vers la généralisation d'une alternative à l'étalement urbain ?Halleux, Jean-Marie  ; Strée, Julie in Cahiers Nouveaux (Les) (2012), 84 Detailed reference viewed: 15 (5 ULg) Phenotypical characterization of alpha-galactosidase A gene mutations identified in a large Fabry disease screening program in stroke in the young.; ; et al in Clinical Neurology & Neurosurgery (2012) OBJECTIVE: In the Belgian Fabry Study (BeFaS), the prevalence of Fabry disease was assessed in 1000 young patients presenting with stroke, unexplained white matter lesions or vertebrobasilar ... [more ▼] OBJECTIVE: In the Belgian Fabry Study (BeFaS), the prevalence of Fabry disease was assessed in 1000 young patients presenting with stroke, unexplained white matter lesions or vertebrobasilar dolichoectasia. The results of the BeFaS suggested that Fabry disease may play a role in up to 1% of young patients presenting with cerebrovascular disease. However, the clinical relevance was unclear in all cases. We report on detailed phenotyping in subjects identified with alpha-galactosidase A (alpha-Gal A) enzyme deficiency or GLA mutations identified in the BeFaS (n=10), and on the results of family screening in this population. METHODS: Family screening was performed to identify additional mutation carriers. Biochemical and/or clinical evaluation of all subjects (BeFaS index patients and relatives carrying a GLA mutation) was performed. RESULTS: Genetic family screening revealed 18 additional GLA mutation carriers. Bloodspot alpha-Gal A enzyme activity was normal in all GLA mutation carriers, even in 2 males with the p.A143T mutation. Plasma Gb3 and lyso-Gb3 levels were normal in all subjects. Elevated Gb3 in urine was detected in 2 subjects. Some classic clinical signs of Fabry disease, like angiokeratoma or cornea verticillata, could not be detected in our population. Cardiac symptoms of Fabry disease were found in 6 out of 10 p.A143T carriers. No signs of cerebrovascular disease were found in the relatives with a GLA mutation. CONCLUSIONS: We could not identify mutations causing the classical clinical phenotype of Fabry disease in our cerebrovascular disease population. Enzyme activity analysis in bloodspots and plasma may fail to identify late-onset variants of Fabry disease. We recommend genetic testing when an atypical, late-onset variant of Fabry disease is suspected in a male cerebrovascular disease patient. However, this may lead to the identification of non-disease causing or controversial genetic variants. [less ▲] Detailed reference viewed: 24 (0 ULg) Seasonal change of Lymnaeid snails intermediate host of Fasciola gigantica in North and Central VietnamBui Thi, Dung ; ; et alConference (2012, December) Objective: The present study was undertaken to investigate the population dynamics of the intermediate hosts of Fasciola gigantica and the levels of infection in the snails. This would allow identifying ... [more ▼] Objective: The present study was undertaken to investigate the population dynamics of the intermediate hosts of Fasciola gigantica and the levels of infection in the snails. This would allow identifying the most important transmission periods and suggesting optimal snail control for the area. Methods: Lymnaeid snails were monthly collected by hand picking in Ha Noi (Northern Vietnam) during the period from March 2010 to December 2011 and in Binh Dinh province (Central Vietnam) during the period May and September 2012. Collected snails from different sites were identified based on morphology and the partial 16S rDNA sequence and ITS-2 sequence. Snails were examined for the presence of Fasciola larval by the crushing method and confirmation by multiplex PCR analyses with PCR primer for Fasciola gigantica cathepsin L in parallel with the snail rDNA species specific primer. Result: The density of Lymnaeid populations underwent great changes in relation to the geographical locations and seasons. In Central Vietnam, the Lymnaeid populations reached the peak in the dry/rainy season (May) and decreased sharply in rainy/dry season (September). In contrast, in Hanoi, it reached the peaks in 2 periods (February to April and August to November) of rice cultivation or early stage of growing of rice, and greatly deceased when the rice becomes fully developed. Transmission of fascioliasis in Ha Noi were high when rice cultivation is performed, while the permanent transmission can takes place through the year in Binh Dinh with peak transmission during the dry season. [less ▲] Detailed reference viewed: 18 (3 ULg)Phylogeography of the garden dormouse Eliomys quercinus in the western Palearctic region; Libois, Roland ; in Journal of Mammalogy (2012), 93(6), The garden dormouse, Eliomys quercinus (Rodentia, Gliridae), displays a surprisingly high karyotypic diversity, with the number of chromosomes varying between 2N ¼ 48 and 2N ¼ 54. We aimed to assess ... [more ▼] The garden dormouse, Eliomys quercinus (Rodentia, Gliridae), displays a surprisingly high karyotypic diversity, with the number of chromosomes varying between 2N ¼ 48 and 2N ¼ 54. We aimed to assess whether the karyotypic diversity is congruent with the mitochondrial differentiation of the populations; improve our understanding of the taxonomic relationships between garden dormouse populations based on both chromosomal and mitochondrial information; and establish the phylogeographic history of the species and the time of differentiation of mitochondrial lineages of E. quercinus and E. melanurus. For this purpose we sequenced the mitochondrial cytochrome-b (Cytb) gene for 62 E. quercinus and 4 E. melanurus from 27 localities representing all the known chromosomal races of the genus Eliomys in the western Palearctic region. Our results 1st showed that populations of E. quercinus are separated into 4 evolutionarily significant units partially congruent with the chromosomal races and corresponding to Iberian (2N¼48), Italian (2N¼48 or 50), western European (2N¼48, 49, or 50), and Alpine (2N ¼ 52 or 54) mitochondrial lineages or clades. The existence of hybrid individuals between chromosomal races and the presence of several chromosomal races within each mitochondrial lineage both indicate that gene flow persists between chromosomal races. Second, we estimated that the major mitochondrial lineages differentiated from each other around 4.2 6 SD 1 million years ago, thus predating the Quaternary glaciations. Third, E. quercinus displayed a higher haplotypic variability in the Mediterranean peninsula than in the northwestern European populations. However, E. quercinus did not show a pattern of ostglacial recolonization of northwestern Europe from Iberian or Italian populations. Our results also suggest that additional, unexpected refuge regions around the Alps exist for the species. Such information will be useful for deciphering the priorities for the protection of E. quercinus, which is listed as ‘‘Near Threatened’’ on the International Union for the Conservation of Nature Red List of Threatened Species and is protected by Appendix III of the Bern Convention. [less ▲] Detailed reference viewed: 38 (5 ULg)The usefulness of CPTs for deterministic, spatially heterogeneous, large-scale aquitard parametrisation; ; et al in Oswald, S.E.; Kolditz, O.; Attinger, S. (Eds.) Models - Repositories of Knowledge (2012, December) Aquitards can be effectively parameterised and incorporated in a groundwater flow model by using standard cone penetration tests (CPTs). Several conceptually different realizations of an aquitard’s ... [more ▼] Aquitards can be effectively parameterised and incorporated in a groundwater flow model by using standard cone penetration tests (CPTs). Several conceptually different realizations of an aquitard’s hydraulic conductivity field were evaluated based on: (i) conventional methods of soil behaviour type classification, (ii) recent relationships from the literature, and (iii) novel site-specific relations with hydraulic conductivity. We show that use of most of these CPT-based hydraulic conductivity estimations in groundwater flow modelling effectively enhance model performance based on absolute head values and gradients across the aquitard. Conceptual models that considered a spatially heterogeneous hydraulic conductivity for the aquitard performed better than the reference case with a uniform aquitard hydraulic conductivity. However, the hydraulic conductivity of thin heavy clay lenses, characteristic of the aquitard present in our study area, cannot be captured using these continuum approaches. The latter leads to a bias in the direct hydraulic conductivity predictions; an alternative is to invoke inverse modelling with the heterogeneous parameter fields. To address this issue, the concept of the boundary energy associated with the CPT signal is also introduced for characterising the presence of heavy clay lenses. Overall, the CPT-based concepts provide more accurate, robust, and high-resolution data-based parameterisation of the studied aquitard. [less ▲] Detailed reference viewed: 25 (5 ULg)Vers une meilleure caractérisation des étapes de décomposition cadavériqueFocant, Jean-François in Bulletin d'information: Toxicologie médico-légale. Questions ouvertes (2012), (11), 1-2 Detailed reference viewed: 11 (0 ULg)Il y a 40 ans, une comète liégeoiseManfroid, Jean Article for general public (2012) Detailed reference viewed: 9 (3 ULg)Identité et cognitionBrédart, Serge ; Van der Linden, Martial Book published by de boeck (2012) This book mainly addresses the following topics: (1) self-consciousness in "normal" children and adults, and in patients with neuropsychological or psychopathological disorders, (2) the relationship ... [more ▼] This book mainly addresses the following topics: (1) self-consciousness in "normal" children and adults, and in patients with neuropsychological or psychopathological disorders, (2) the relationship between self-awareness and episodic memory, and finally (3) self-projection into the future [less ▲] Detailed reference viewed: 24 (1 ULg)Migrations congolaises (RDC) en Belgique et postcolonialismesDemart, Sarah Conference (2012, December) Mass transport in carbon gels with tuned porosityJob, Nathalie in Spanish Carbon Group Bulletin (2012) Detailed reference viewed: 13 (2 ULg)Participatory approaches for evaluating surveillance systems: insights from a training- related study from VietnamAntoine-Moussiaux, Nicolas ; ; et alConference (2012, December) Detailed reference viewed: 11 (1 ULg)Optimal discovery with probabilistic expert advice; Ernst, Damien ; in Proceedings of the 51st IEEE Conference on Decision and Control (CDC 2012) (2012, December) Motivated by issues of security analysis for power systems, we analyze a new problem, called optimal discovery with probabilistic expert advice. We address it with an algorithm based on the optimistic ... [more ▼] Motivated by issues of security analysis for power systems, we analyze a new problem, called optimal discovery with probabilistic expert advice. We address it with an algorithm based on the optimistic paradigm and the Good-Turingmissing mass estimator. We show that this strategy attains the optimal discovery rate in a macroscopic limit sense, under some assumptions on the probabilistic experts. We also provide numerical experiments suggesting that this optimal behavior may still hold under weaker assumptions. [less ▲] Detailed reference viewed: 7 (2 ULg)L'eLearning et les femmes : retour d'expérience. Une étude exploratoire auprès de 22 femmesLesire, Catherine ; Géron, Stéphanie ; Georges, François in Paliard, C.; Nkambou, R.; Narce, C. (Eds.) et al Actes du 8ème Colloque Technologies de l’Information et de la Communication pour l’Enseignement: Intégration Technologique et Nouvelles Perspectives d’Usage (2012, December) Who are the women who learn online ? Why and in which circumstances have they chosen to learn online ? Have they taken advantage of this experience ? In this article, we speak about the exploratory survey ... [more ▼] Who are the women who learn online ? Why and in which circumstances have they chosen to learn online ? Have they taken advantage of this experience ? In this article, we speak about the exploratory survey carried out with 22 women to know their motivation in online courses, what they did during those courses and what they remember of their experience. We also wanted to know whether eLearning gave women the opportunity to learn and to be trained even when they have a lot of responsabilities and sometimes little time to learn. [less ▲] Detailed reference viewed: 28 (10 ULg)Eschatologies apocalyptique et millénaristes : christianisme et fin des tempsDelfosse, Annick Article for general public (2012) Detailed reference viewed: 31 (6 ULg)Belgique boom. Les défis d'une croissance démographique inédite depuis les années 60Halleux, Jean-Marie Article for general public (2012) Lors des années deux-mille, la Belgique a retrouvé une croissance démographique inédite depuis les années soixante, avec des taux de croissance annuels compris entre le demi-pourcent et le pourcent ... [more ▼] Lors des années deux-mille, la Belgique a retrouvé une croissance démographique inédite depuis les années soixante, avec des taux de croissance annuels compris entre le demi-pourcent et le pourcent. Derrière ces taux, qui peuvent sembler faibles, se cache un peuplement de plus de 600.000 personnes. En une dizaine d’année, la Belgique a donc dû répondre aux besoins d’une population nouvelle supérieure à la population d’une ville telle qu’Anvers. Sur base des perspectives démographiques calibrées par le Bureau fédéral du Plan , des taux aussi élevés devraient se maintenir lors des prochaines décennies, pour faire de la Belgique un pays de plus de 13 millions d’habitants à l’horizon 2050 (contre ± 11 millions actuellement). [less ▲] Detailed reference viewed: 14 (4 ULg)Prevalence of HIV and HCV infections in two populations of Malian women and serological assays performances; VAIRA, Dolorès ; Gothot, André et alin World Journal of Hepatology (2012) Detailed reference viewed: 12 (5 ULg)Automatic X-ray fluorescence scanning mobile system for 2D chemical analysisStrivay, David ; ; et alConference (2012, December) Detailed reference viewed: 14 (0 ULg)Théories des relations internationalesSantander, Sébastian Learning material (2012) Detailed reference viewed: 15 (3 ULg)Comparative Nationality Law - Selected Questions (2012)Wautelet, Patrick Learning material (2012) These slides were used as support for a course taught in English (in 2012) which provides an overview of the major questions arising in the field of nationality law. The course focuses on acquisition and ... [more ▼] These slides were used as support for a course taught in English (in 2012) which provides an overview of the major questions arising in the field of nationality law. The course focuses on acquisition and loss of nationality and touches upon other issues such as multiple nationalities and the influence of the European construction on nationality law. All these questions are studied using comparative materials (mainly from Western Europe) as basis. Reference is also made to the European Convention on Nationality (1997) as well as to other relevant international instruments dealing with nationality law. [less ▲] Detailed reference viewed: 29 (0 ULg)Étude comparative de la répartition des matières et des apprentissages en langues anciennes dans l’enseignement francophone européenPietquin, Paul in Dufays, J.-L.; Carlier, Gh.; De Kesel, Myriam (Eds.) et al Progression et transversalité. Comment (mieux) articuler les apprentissages dans les disciplines scolaires ? (2012, December) Detailed reference viewed: 13 (2 ULg) |
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