Physico-chemical characterization and in vitro hemocompatbility study of nanocarriers tailored for biopharmaceutical drugs

Conference (2012, December 04)

Introduction aux théories de la perception du paysage

Speech (2012)

La perception du paysage est abordée sous l'angle de l'école behavioriste, plus particulièrement les travaux de Kevin Lynch en urbanisme sur l'image de la ville. Elle part du postulat que la perception de ... [more ▼]

La perception du paysage est abordée sous l'angle de l'école behavioriste, plus particulièrement les travaux de Kevin Lynch en urbanisme sur l'image de la ville. Elle part du postulat que la perception de l'environnement influence le comportement de l'individu qui y vit (le citoyen)et modifie à son tour son environnement. Ceci sert à dégager des principes d'aménagement du territoire pour plus de bien-être. La voirie joue un rôle central dans la perception de la ville, étant donné que c'est le point d'observation principal de celle-ci par les citoyens. Selon sa forme, ses accès et ses abords, ou encore l'organisation de l'écran construit, différents effets d'ambiance urbaine peuvent être ménagés. Dans ce paysage s'implantent les éléments principaux de la structure de la ville: limites, voies, noeuds, points de repère, quartiers. Leur organisation relative fait émerger les caractéristiques globales de la ville que sont la lisibilité et l'imagibilité. Ces techniques ont été utilisées et adaptées pour l'analyse de la ville de Lubumbashi et de l'Avenue Louise à Bruxelles. [less ▲]

Future surface mass balance contribution of the Antarctic ice-sheet to sea level rise

Scientific conference (2012, December 04)

Most of the IPCC-AR4 global circulation models predict an increase of the Antarctic Surface Mass Balance (SMB) during the 21st century that would mitigate global sea level rise. High-resolution modeling ... [more ▼]

Most of the IPCC-AR4 global circulation models predict an increase of the Antarctic Surface Mass Balance (SMB) during the 21st century that would mitigate global sea level rise. High-resolution modeling is necessary to adequately capture the Antarctic SMB, that is why we present here a downscaling method leading to 15-km SMB resolution for century time-scales over Antarctica. Our first results show that a higher resolution induce at the same time more run-off but a significantly higher mitigation of sea level rise for the next centuries. [less ▲]

Survival analysis: finding relevant epistatic SNP pairs using Model- Based Multifactor Dimensionality Reduction

Conference (2012, December 03)

Analyzing the combined effects of genes (and/or environmental factors) on the development of complex diseases is quite challenging, both from the statistical and computational perspective, even using a ... [more ▼]

Analyzing the combined effects of genes (and/or environmental factors) on the development of complex diseases is quite challenging, both from the statistical and computational perspective, even using a relatively small number of genetic and non-genetic exposures. Several data-mining methods have been proposed for interaction analysis, among them, the Multifactor Dimensionality Reduction Method (MDR). Model-Based Multifactor Dimensionality Reduction (MB-MDR), a relatively new dimensionality reduction technique, is able to unify the best of both nonparametric and parametric worlds, and has proven its utility in a variety of theoretical and practical settings. Until now, MB-MDR software has only accommodated traits that are measured on a binary or interval scale. Time-to-event data could therefore not be analyzed with the MB-MDR methodology. MB-MDR-3.0.0 overcomes this shortcoming of earlier versions. We show the added value of MB-MDR for censored traits by comparing the implemented strategies with more classical methods such as those based on a parametric regression paradigm. The simulation results are supplemented with an application to real-life data. [less ▲]

Tailor-made degradable copolymers for the design of advanced drug delivery systems

Conference (2012, December 03)

Changement climatique 2012

Scientific conference (2012, December 03)

Microlensing Binaries with Candidate Brown Dwarf Companions

in Astrophysical Journal (2012), 760

Brown dwarfs are important objects because they may provide a missing link between stars and planets, two populations that have dramatically different formation histories. In this paper, we present the ... [more ▼]

Brown dwarfs are important objects because they may provide a missing link between stars and planets, two populations that have dramatically different formation histories. In this paper, we present the candidate binaries with brown dwarf companions that are found by analyzing binary microlensing events discovered during the 2004-2011 observation seasons. Based on the low mass ratio criterion of q < 0.2, we found seven candidate events: OGLE-2004-BLG-035, OGLE-2004-BLG-039, OGLE-2007-BLG-006, OGLE-2007-BLG-399/MOA-2007-BLG-334, MOA-2011-BLG-104/OGLE-2011-BLG-0172, MOA-2011-BLG-149, and MOA-201-BLG-278/OGLE-2011-BLG-012N. Among them, we are able to confirm that the companions of the lenses of MOA-2011-BLG-104/OGLE-2011-BLG-0172 and MOA-2011-BLG-149 are brown dwarfs by determining the mass of the lens based on the simultaneous measurement of the Einstein radius and the lens parallax. The measured masses of the brown dwarf companions are 0.02 ± 0.01 M [SUB]&sun;[/SUB] and 0.019 ± 0.002 M [SUB]&sun;[/SUB] for MOA-2011-BLG-104/OGLE-2011-BLG-0172 and MOA-2011-BLG-149, respectively, and both companions are orbiting low-mass M dwarf host stars. More microlensing brown dwarfs are expected to be detected as the number of lensing events with well-covered light curves increases with new-generation searches. [less ▲]

Comment installer et utiliser Endnote Web pour réaliser une bibliographie automatique dans MS Word

Learning material (2012)

Ce petit document vous apprendra en 20 minutes à installer et utiliser le logiciel libre « Endnote Web » qui permet de : a) Créer une base de données bibliographique personnelle et en ligne; b) Insérer et ... [more ▼]

Ce petit document vous apprendra en 20 minutes à installer et utiliser le logiciel libre « Endnote Web » qui permet de : a) Créer une base de données bibliographique personnelle et en ligne; b) Insérer et formater automatiquement une bibliographie dans un document Microsoft Word (Office) [less ▲]

Secondary eclipse scanning of HD189733b: The perspectives of mapping distant worlds

in Astronomy and Astrophysics (2012), 548

Context. Mapping the brightness distribution of exoplanets is the next frontier for exoplanet infrared photometry studies. For tidally-locked hot Jupiters that transit and are eclipsed by their host star ... [more ▼]

Context. Mapping the brightness distribution of exoplanets is the next frontier for exoplanet infrared photometry studies. For tidally-locked hot Jupiters that transit and are eclipsed by their host star with non-zero impact parameter, the first steps are now possible. Aims. The aim is to use eclipse scanning from occultation ingress/egress and phase curve measurements to constrain exoplanet large-scale brightness structure. Methods. We use archived Spitzer/IRAC 8 {\mu}m data of HD189733 in a global MCMC procedure encompassing six transits, eight secondary eclipses, and a phase curve in a two-step analysis. The first step derives the planet-star system parameters. The second step investigates the structure found in eclipse scanning, using the previous planet-star system parameter derivation as Gaussian priors. Results. We find a 5-sigma deviation from the expected occultation ingress/egress shape for a uniform brightness disk, and demonstrate that this is dominated by large-scale brightness structure and not an occultation timing offset due to a non-zero eccentricity. Our analysis yields a 2D brightness temperature distribution showing a large-scale asymmetric hot spot whose finer structure is limited by the data quality and planet orbit geometry. We also present an improved upper limit for eccentricity, e<0.0081 (95% confidence). Conclusions. Reanalysis of archived HD 189733 data revealed brightness structure by using global analysis that mitigated systematics. Future eclipse scanning observations of the same exoplanet at other wavelengths will probe different atmosphere layers, ultimately generating a large-scale 3D map. [less ▲]

CONTRIBUTION OF THE NEW TECHNOLOGIES TO THE REHABILITATION OF THE OLD FALLERS : A PILOT STUDY

in Gériatrie et Psychologie Neuropsychiatrie du Vieillissement (2012), 10(4), 383-390

Purpose of the study: to verify the interest of vibrosphère™ in the rehabilitation of geriatric fallers Material and method: 24 persons aged 85.5 hospitalized in geriatric wards for a fall during the last ... [more ▼]

Purpose of the study: to verify the interest of vibrosphère™ in the rehabilitation of geriatric fallers Material and method: 24 persons aged 85.5 hospitalized in geriatric wards for a fall during the last 6 months are divided in 2 groups. The group one has performed a classical revalidation and the group 2 a rehabilitation with the technics of vibrosphère™, both during 9 days. The assessment is realized on Day 0 and day 10. It consists in a walking test with Locometrix, a postural assessment a time get up and go and the fall efficacity scale. A control group of 20 non faller subjects aged 79,9 is constituted. Results: in the second population a gain (p< 0.05) is obtained for speed of gait, and also a tendancy in a better frequency, length, symmetry and regularity of step. Postural status is better at the end of the 9 days in the grouped using vibrosphère™. The 2 ways of rehabilitation have similar effects on the gait and balance parameters. Conclusion: our study confirms efficiency of rehabilitation program for 9 days which is rather short. The improvements show that vibrosphère™ is a well adapted tool to revalidate geriatric fallers. Its effect on balance should explain the benefit observed in the gait parameters. This technique seems to be complementary with classical rehabilitation in old geriatric hospitalized patients. [less ▲]