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See detailCollaborative care in the addiction management of alcohol, illicit drugs and hypnotics and tranquilizers in the Belgian working population
Van Royen, Kathleen; Remmen, Roy; Vanmeerbeek, Marc ULg et al

Poster (2012, October)

Background: General practitioners (GPs) and occupational physicians (OPs) play an important role in detecting and managing substance abuse in the working population. Their collaboration is critical in ... [more ▼]

Background: General practitioners (GPs) and occupational physicians (OPs) play an important role in detecting and managing substance abuse in the working population. Their collaboration is critical in coordinating care, facilitate a quicker rehabilitation and shorten sickleave. A systematic literature search was performed according to the ADAPTE-framework to explore if guidelines exist for collaboration between GPs and OPs in substance abuse management. Method: International guidelines regarding collaborative care for alcohol abuse, illicit drug use and hypnotics and tranquilizers were identified by a detailed systematic search in the Guidelines International Network (GIN) and US National Guidelines Clearinghouse (NGC) databases. Results: In total 20 guidelines were considered of sufficient methodological quality, based on criteria of the Appraisal of Guidelines for Research and Education (AGREE) II instrument. Two out of 20 eligible guidelines reported on the role of OPs. There is a lack of adequate evidence on the role of the OP in substance abuse management. No practical avenues for collaboration between GPs and OPs in the management of substance abuse were suggested. Conclusions: In order to ensure adequate substance abuse management, collaborative models for general practice and occupational health should be developed. We recommend to study pros and cons for collaboration as well as the best way to achieve it. [less ▲]

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See detailConcept of a mobile automatic milking system and first results at grazing
Dufrasne, Isabelle ULg

in Proceedings 2nd meeting EGF Working Group Grazing - Innovation in grazing (2012, October)

In Europe, farmers have to manage larger herds but, at the same time, want to have a normal social life. So, the automatic milking system (AMS) can bring solutions. This technology implies in most cases ... [more ▼]

In Europe, farmers have to manage larger herds but, at the same time, want to have a normal social life. So, the automatic milking system (AMS) can bring solutions. This technology implies in most cases, the cessation of grazing although grazing is appreciated by the consumers who consider it to be a natural practice. At the experimental farm of the University of Liege, the concept of a mobile milking robot has been developed with a private company. The prototype is used indoors during the winter season and is moved outdoors during the grazing season in pastures romote from the farm. [less ▲]

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See detailRestoration Of B Cells Correlates With Clinical Response To Anti-Tnf Therapy
Li, Z; Vermeire, S; Bullens, D et al

Poster (2012, October)

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See detailThe Pair Beam Production Spectrum from Photon-Photon Annihilation in Cosmic Voids
Schlickeiser, Reinhard; Elyiv, Andrii ULg; Ibscher, D et al

in Astrophysical Journal (2012), 758(2), 18

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See detailAntibiotherapy in bovine mastitis – Drugs or Therapeutics?
Theron, Léonard ULg; Hanzen, Christian ULg

Conference given outside the academic context (2012)

The 21st century is rich in mutations regarding veterinary medicine; society has never been so far from farm animal practices in industrialized countries, and so demanding in developing nations for a ... [more ▼]

The 21st century is rich in mutations regarding veterinary medicine; society has never been so far from farm animal practices in industrialized countries, and so demanding in developing nations for a continuous milk and meat production. Meanwhile, even this great distance in northern nations between agriculture and society, our work has never been so much analyzed for its potential risk on human health and production quality. As health is now globalized, following trade and science, exchange could be the source of several pathological emergences. Focusing on animal health, our responsibility toward “larga manu” use of antibiotics has been identified and criticized. This situation is also happening in a time where, nevertheless our industrialization of agricultural production, ancillary exams are still expensive, and most of the time non valuable regarding a common cattle practice time schedule. So yes, we are mainly still experiencing empirical use of antibiotics like our pairs did, back several decades before. Yet, there exists nowadays many tools to analyze whether our practice could be considered as harmful to humanity survival and good use of priority antibiotics. We therefore have to reconsider our practice of Antibiotherapy, regarding these new challenges and find new ways for medical management of infectious diseases. [less ▲]

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See detailApprentissage et contenus en fonction de l’âge
Jidovtseff, Boris ULg; Theunissen, Catherine ULg

Learning material (2012)

Ces notes présentent l'évolution de l'apprentissage en fonction de l'âge.

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See detailSynthèse de MWNT dans un réacteur continu incliné rotatif à lit mobile par procédé CCVD
Douven, Sigrid ULg; Pirard, Sophie ULg; Chan, Fang-Yue et al

Conference (2012, October)

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See detailExpression et localisation spatio-temporelle de KISS1 et de son récepteur KISSR dans le placenta normal et pathologique.
VALDES SOCIN, Hernan Gonzalo ULg; Munaut, Carine ULg; CHAVEZ, Viviana ULg et al

Poster (2012, October)

Objectif : Etudier l’expression de KISS1 (métastatine) et de son récepteur KISS1R lors de la grossesse normale et pathologique. Matériels et méthodes : Nous avons étudié la localisation de KISS1 et KISS1R ... [more ▼]

Objectif : Etudier l’expression de KISS1 (métastatine) et de son récepteur KISS1R lors de la grossesse normale et pathologique. Matériels et méthodes : Nous avons étudié la localisation de KISS1 et KISS1R par immunohistochimie dans des placentas normaux (1 er et 3 ème trimestre). Par RT-PCR quantitative, nous avons évalué le niveau d’expression des ARNm dans les placentas et les lits placentaires correspondants. Les niveaux d’expression de ARNm ont été comparés entre les grossesses normales (GN, n=13) et les grossesses spathologiques Prééclampsiques -PE-, n=17 et retard de croissance intrautérine -RCIU-, n=9). Résultats : Au premier trimestre des GN, KISS1 est majoritairement localisé dans les syncitiotrophoblastes, alors que KISS1R est détecté dans le mesenchyme villositaire. Au cours du troisième trimestre, KISS1 est uniquement localisé dans le syncitiotrophoblaste au contact avec la décidue et dans le mésenchyme villositaire et KISS1R est détecté dans le trophoblaste extra-villeux ainsi que dans quelques cellules de la décidue. Les analyses par RT-PCR mettent en évidence une expression plus importante des ARNm de KISS1 (p<0,001) et de KISS1R (p=0.039) dans les placentas (GN,PE et RCIU) par rapport aux lits placentaires correspondants. Les niveaux d’expression de KISS1 et KISS1R ne sont pas, cependant, significativement modulés dans les grossesses pathologiques. Conclusions : Par immunohistochimie, nos résultats indiquent une expression spatiotemporelle différente pour KISS1 et KISS1R entre le 1 er et 3 ème trimestre des grossesses normales. Nous n’avons pas mis en évidence de modulation de l’expression des ARNm dans les grossesses pathologiques. [less ▲]

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See detailRADIATION SHIELDING OF COMPOSITE SPACE ENCLOSURES
Atxaga, G.; Marcos, J.; Jurado, M. et al

Conference (2012, October)

Space electronic systems employ enclosures to shield sensitive components from space radiation. The purpose of shielding is to attenuate the energy and the flux of ionizing radiation as they pass through ... [more ▼]

Space electronic systems employ enclosures to shield sensitive components from space radiation. The purpose of shielding is to attenuate the energy and the flux of ionizing radiation as they pass through the shield material, such that the energy per unit mass (or dose) absorbed in silicon is sufficiently below the maximum dose ratings of electronic components. The received radiation amount varies significantly depending on several variables that include mission parameters (orbit, altitude, inclination and duration), spacecraft design (spacecraft wall thickness and panel-enclosure location). To achieve the optimum shielding with the minimum weight, all these variables have to be considered in the design. Energetic particles, mainly electrons and protons, can destroy or cause malfunctions in spacecraft electronics. The standard practice in space hardware is the use of aluminium as both a radiation shield and structural enclosure. Composite structures show potential for significant mass savings. However, conventional graphite epoxy composites are not as efficient shielding materials as aluminium because of their lower density, that is, for the same mass, composites provide 30 to 40% less radiation attenuation than aluminium. A solution is to embed high density (atomic weight) material into the laminate. This material, typically metallic material, can be dispersed in the composite or used as layers in the laminate (foils). The main objective of the “Radiation Shielding of Composite Space Enclosures” (SIDER) project is the development of the technologies and tools required to obtain lightweight, safe, robust and reliable composite structures. Two different strategies are being analysed as alternatives for radiation shielding: and he incorporation of a high density material foil. This paper will present and analyse the radiation shielding obtained by the incorporation of nanomaterials in composite structures. [less ▲]

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See detailParodie de la science et réflexivité. La Physiologie et le dictionnaire dans le champ littéraire français du XIXe siècle
Stienon, Valérie ULg; Saint-Amand, Denis ULg

in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (2012), Volume 3

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See detailNonlinear Dynamic Analysis of Aerospace Structures
Kerschen, Gaëtan ULg; Noël, Jean-Philippe ULg; Renson, Ludovic ULg et al

Conference (2012, October)

Current practice in industry is to rely on linear finite element simulations. However, nonlinearity is a frequent occurrence in engineering structures. It is at the origin of rich and complex dynamical ... [more ▼]

Current practice in industry is to rely on linear finite element simulations. However, nonlinearity is a frequent occurrence in engineering structures. It is at the origin of rich and complex dynamical phenomena that cannot be observed in linear structures. Solving both the direct and inverse problems in nonlinear structural dynamics therefore warrants the development of appropriate methodologies. The focus of the presentation will first be on the inverse problem. We will describe the different steps of the nonlinear system identification process and discuss the current capabilities of existing methods. The presentation will then address the direct problem during which the identified model is used for accurately predicting the structure’s dynamic characteristics. A rigorous nonlinear extension of modal analysis will be presented, and we will show that it represents a very useful framework for understanding nonlinear dynamical phenomena and supporting design decisions. Two real-life aerospace structures will be considered for illustrating the proposed developments. [less ▲]

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See detailDessine-moi un Hôpital de jour : dessein du cadre thérapeutique
Close, mireille; Landauer, valérie; Noirfalise, Stéphanie et al

in Revue des Hôpitaux de Jour Psychiatriques et des Thérapies Institutionnelles (2012), 14

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See detailNEW CHALLENGES FOR 21ST CENTURY COMPETITION AUTHORITIES
Petit, Nicolas ULg

E-print/Working paper (2012)

This paper discusses challenges for competition authorities in the 21st century. Those challenges were identified on the basis of a statistical review of the articles published since January 2011 in five ... [more ▼]

This paper discusses challenges for competition authorities in the 21st century. Those challenges were identified on the basis of a statistical review of the articles published since January 2011 in five major antitrust law journals. The assumption underlying this literature review is that the topics that statistically attract the most the attention from contemporary antitrust scholars are those that will likely constitute the main challenges for 21st century competition authorities. [less ▲]

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See detailEvidence for a role of a cortico-subcortical network for automatic and unconscious motor inhibition of manual responses
D'Ostilio, Kevin ULg; Collette, Fabienne ULg; Phillips, Christophe ULg et al

in PLoS ONE (2012)

It is now clear that non-consciously perceived stimuli can bias our decisions. Although previous researches highlighted the importance of automatic and unconscious processes involved in voluntary action ... [more ▼]

It is now clear that non-consciously perceived stimuli can bias our decisions. Although previous researches highlighted the importance of automatic and unconscious processes involved in voluntary action, the neural correlates of such processes remain unclear. Basal ganglia dysfunctions have long been associated with impairment in automatic motor control. In addition, a key role of the medial frontal cortex has been suggested by administrating a subliminal masked prime task to a patient with a small lesion restricted to the supplementary motor area (SMA). In this task, invisible masked arrows stimuli were followed by visible arrow targets for a left or right hand response at different interstimuli intervals (ISI), producing a traditional facilitation effect for compatible trials at short ISI and a reversal inhibitory effect at longer ISI. Here, by using fast event-related fMRI and a weighted parametric analysis, we showed BOLD related activity changes in a cortico-subcortical network, especially in the SMA and the striatum, directly linked to the individual behavioral pattern. This new imaging result corroborates previous works on subliminal priming using lesional approaches. This finding implies that one of the roles of these regions was to suppress a partially activated movement below the threshold of awareness. [less ▲]

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See detailStudy of the Boettcher cells along their development: Junctions and expression of the urea-transporter B (UT-B)
Cloes, Marie ULg; Renson, Thomas; Johnen, Nicolas ULg et al

Poster (2012, September 30)

The Boettcher cells (BC) lie on the sensory epithelium of the cochlea. Their function has never been clearly defined. However it has been suggested that they may influence the ionic composition of the ... [more ▼]

The Boettcher cells (BC) lie on the sensory epithelium of the cochlea. Their function has never been clearly defined. However it has been suggested that they may influence the ionic composition of the fluids of the inner ear, which play a central role in the conduction of the sensory information. In this context the compartimentating function of the BC around and after the onset of hearing may influence the subsequent refining of hearing. We collected ultrastructural and immunohistological data during the final maturation stage of the sensory epithelium. In particular the cell junctions were investigated to clarify the compartimentating function of the BC at early stages. As a potential actor in the ion flow in the sensory epithelium, the urea transporter-B (UT-B) was also immunolocalised during the development of the BC. At the mature stage (P25) the BC are linked to the adjacent cells by numerous adherens and non-adherens junctions. They rest on a basilar membrane to which they are attached by hemidesmosomes. They typically exhibit large basolateral interdigitations. We found that, at the 8th postnatal day, the BC are separated from the neighbouring cells by wide spaces entered by scarce cytoplasmic extensions. These spaces are interrupted by areas of close contact, where adherens and non-adherens junctions may be found. Thus, although there seems to be fewer interdigitations at P8, gap junctions probably still allow easy cell-to-cell exchanges. Moreover non-adherens junctions can systematically be identified apically. Although it was impossible to differenciate tight and gap junctions without specific labeling, we postulate that these non-adherens junctions correspond to tight junctions and seal the apex of the BC. This feature is necessary to enable the control of the ion concentrations surrounding the sensory epithelium. We also found that UT-B, known for water and urea transport in red blood cells, is present in the membranes of the BC from P12 (the earliest stage tested) to P25. Thus UT-B may play a role in the regulation of the ionic concentrations of the inner ear fluids. [less ▲]

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See detailWhen should we measure Vitamin D in Clinical Practice
CAVALIER, Etienne ULg

Conference (2012, September 29)

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See detailTransplantation et don d'organes en Belgique
DETRY, Olivier ULg

Conference (2012, September 29)

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See detailHjelmslev's notion of "Participation"
Cigana, Lorenzo ULg

Conference (2012, September 29)

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See detailCardiac surgery and acute kidney injury: retrospective study
LAGNY, Marc-Gilbert ULg; BLAFFART, Francine ULg; Defraigne, Jean-Olivier ULg et al

Conference (2012, September 29)

Background: In cardiac surgery, acute kidney injury (AKI) is a severe postoperative complication and associated with increased rates of mortality, morbidity, and length of stay in intensive care units ... [more ▼]

Background: In cardiac surgery, acute kidney injury (AKI) is a severe postoperative complication and associated with increased rates of mortality, morbidity, and length of stay in intensive care units (ICU). It occurs in 5% to 30% of patients depending on the definition used [1] [2] [3]. The aim of this study is to present an overview of AKI following cardiac surgery associated or not with cardiopulmonary bypass. Methods: This retrospective study includes patients treated by cardiac surgery from April 1st, 2008 to March 31th, 2009 in a single center. We selected patients who underwent on-pump coronary artery bypass surgery (CABG), off-pump CABG (OPCAB), aortic valve replacement, mitral valve repair or replacement and aortic valve replacement combined with CABG. Patients undergoing renal replacement therapy preoperatively were excluded. The RIFLE classification (Risk, Injury, Failure, Loss and End stage kidney disease) allowed to stratify the patients into the 3 grades of AKI severity. The stratification was based on the most pejorative element observed within 7 days after surgery: increased serum creatinine level or decreased urine output, or decreased glomerular filtration rate according to criteria of Bellomo [4]. Occurrence of AKI was studied by type of cardiac surgery as its impact on the length of stay in ICU and in the hospital. Proportions were compared by the Chi-square test and median values by the Kruskal-Wallis. Results were considered significant at p < 0.05. Results: Four hundred and thirty four patients were included: median (IQR) age 69.0(60.0-76.0) year, 30.2% females, 2.76% urgent/emergent cases. Fifty-eight patients (13.4%) underwent OPCAB, 182(41.9%) on-pump CABG, 104(24.0%) aortic valve replacement, 44(10.1%) mitral valve repair or replacement and 46(10.6%) aortic valve replacement combined with CABG. AKI occurred in 213(49.1%) patients: 79(37.1%) “Risk”, 108(50.7%) “Injury” and 26(12,2%) “Failure”. Occurrence of AKI after OPCAB was 21(9.86%), CABG 80(37.6%), aortic valve replacement 51(23.9%), mitral valve surgery 23(10.8%) and aortic valve replacement combined with CABG 38(17.8%). AKI occurrences differed significantly between the different groups of surgery (p<0.0001). Lengths of stay in ICU were significantly longer (p<0.0001) in AKI group compared with non AKI group: 3(2-4) days versus 2(2-3) days. No difference (p = 0.65) was observed between the two (AKI and NON-AKI) groups in hospital length of stay: 13(10-18) days versus 12(10-16) days. Conclusions: The incidence of AKI is very high in this population as compared to the literature. This may be due to the fact that the three elements of the RIFLE classification for all the population studied have been used: serum creatinine level, urine output and glomerular filtration rate. This study emphasizes the need for clear definition of AKI in order to compare adequately different studies. AKI after cardiac surgery with cardiopulmonary bypass would be further studied in order to develop more appropriate preventive measures. [less ▲]

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See detailMultimodality blood conservation strategy in cardiac surgery with cardiopulmonary bypass : the CHU of Liège experience
ERPICUM, Marie ULg; BLAFFART, Francine ULg; DEFRAIGNE, Jean ULg et al

Poster (2012, September 29)

Introduction: The aim of this study is to analyze the transfusion rates of cardiac surgery patients in a single centre following an in-house strategy of blood conservation. Methods: The data of all adult ... [more ▼]

Introduction: The aim of this study is to analyze the transfusion rates of cardiac surgery patients in a single centre following an in-house strategy of blood conservation. Methods: The data of all adult patients undergoing normothermic cardiac surgery with cardiopulmonary bypass (CPB) over a 1 year period were retrospectively collected (n=491). Management protocols were described. The transfusion rates of allogeneic blood components were recorded: red blood cells (RBC), fresh frozen plasma (FFP) and platelets (PT), as well as the number of units transfused. The timing of transfusion was categorized: during CPB (peroperative period), within the first 48 postoperative hours after wean out CPB (early postoperative period) and during the hospitalisation from surgery until discharge (hospitalisation). The hematocrit values were recorded during CPB, 10 minutes after wean out CPB, after the first 48 postoperative hours and at discharge from hospital. Results: Two hundred and forty-eight patients (50%) received an allogeneic blood component transfusion during hospitalisation. One hundred and twenty-one patients (25%) received RBC during the operative period; the median of units transfused was 2(1-2).The lowest hematocrit value during CPB was 21(19-24) % in median. A cell salvage device was used in each case: the median volume of washed red blood cells transfused was 678(512-891) mL. The median hematocrit value after CPB was 23(21-25) %. One hundred and sixty-five patients (34%) were transfused in the early postoperative period: 27% received RBC, 18% received FFP and 18% received PT. The median of units transfused was 2(1-3) for RBC, 4(2-6) for FFP and 1(1-2) for PT. The median hematocrit value after 48 hours was 32(29-34) % and 32(30-35) % at discharge. Conclusion: The transfusion rates observed in this series are relatively high compared with the literature. Improvements will be made in our practice and protocols management in order to decrease the need of transfusion. This detailed audit of the transfusion practices in our cardiac surgery centre would be helpful to value the effectiveness of further improvements. [less ▲]

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