References of "2012"
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See detail1RM PREDICTION AND LOAD-VELOCITY RELATIONSHIP
Jidovtseff, Boris ULg; Cronin, John; Villaret, Jérémy et al

Poster (2012, October)

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See detailVers une typologie de la réflexivité
Demoulin, Laurent ULg

E-print/Working paper (2012)

Il sera ici question de phénomènes réflexifs qui, au sein d’un texte littéraire, produisent des écarts sensibles et rompent le processus classique de la représentation du réel. Les cas rencontrés sont ... [more ▼]

Il sera ici question de phénomènes réflexifs qui, au sein d’un texte littéraire, produisent des écarts sensibles et rompent le processus classique de la représentation du réel. Les cas rencontrés sont étonnamment divers, tant en ce qui concerne leur structure que les effets produits. C’est pourquoi l’on se propose de les classer en six catégories distinctes : réflexivité autotélique, réflexivité poétique, réflexivité linguistique, réflexivité de l’énonciateur, réflexivité conative et réflexivité référentielle. [less ▲]

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See detailConcept of a mobile automatic milking system and first results at grazing
Dufrasne, Isabelle ULg

in Proceedings 2nd meeting EGF Working Group Grazing - Innovation in grazing (2012, October)

In Europe, farmers have to manage larger herds but, at the same time, want to have a normal social life. So, the automatic milking system (AMS) can bring solutions. This technology implies in most cases ... [more ▼]

In Europe, farmers have to manage larger herds but, at the same time, want to have a normal social life. So, the automatic milking system (AMS) can bring solutions. This technology implies in most cases, the cessation of grazing although grazing is appreciated by the consumers who consider it to be a natural practice. At the experimental farm of the University of Liege, the concept of a mobile milking robot has been developed with a private company. The prototype is used indoors during the winter season and is moved outdoors during the grazing season in pastures romote from the farm. [less ▲]

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See detailStratégie d’exploration neurophysiologique de la myasthénie
WANG, François-Charles ULg

in Lettre du Neurologue (La) : le Courrier du Spécialiste (2012), XVI(8),

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See detailThe Pair Beam Production Spectrum from Photon-Photon Annihilation in Cosmic Voids
Schlickeiser, Reinhard; Elyiv, Andrii ULg; Ibscher, D et al

in Astrophysical Journal (2012), 758(2), 18

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See detailExpression et localisation spatio-temporelle de KISS1 et de son récepteur KISSR dans le placenta normal et pathologique.
VALDES SOCIN, Hernan Gonzalo ULg; Munaut, Carine ULg; CHAVEZ, Viviana ULg et al

Poster (2012, October)

Objectif : Etudier l’expression de KISS1 (métastatine) et de son récepteur KISS1R lors de la grossesse normale et pathologique. Matériels et méthodes : Nous avons étudié la localisation de KISS1 et KISS1R ... [more ▼]

Objectif : Etudier l’expression de KISS1 (métastatine) et de son récepteur KISS1R lors de la grossesse normale et pathologique. Matériels et méthodes : Nous avons étudié la localisation de KISS1 et KISS1R par immunohistochimie dans des placentas normaux (1 er et 3 ème trimestre). Par RT-PCR quantitative, nous avons évalué le niveau d’expression des ARNm dans les placentas et les lits placentaires correspondants. Les niveaux d’expression de ARNm ont été comparés entre les grossesses normales (GN, n=13) et les grossesses spathologiques Prééclampsiques -PE-, n=17 et retard de croissance intrautérine -RCIU-, n=9). Résultats : Au premier trimestre des GN, KISS1 est majoritairement localisé dans les syncitiotrophoblastes, alors que KISS1R est détecté dans le mesenchyme villositaire. Au cours du troisième trimestre, KISS1 est uniquement localisé dans le syncitiotrophoblaste au contact avec la décidue et dans le mésenchyme villositaire et KISS1R est détecté dans le trophoblaste extra-villeux ainsi que dans quelques cellules de la décidue. Les analyses par RT-PCR mettent en évidence une expression plus importante des ARNm de KISS1 (p<0,001) et de KISS1R (p=0.039) dans les placentas (GN,PE et RCIU) par rapport aux lits placentaires correspondants. Les niveaux d’expression de KISS1 et KISS1R ne sont pas, cependant, significativement modulés dans les grossesses pathologiques. Conclusions : Par immunohistochimie, nos résultats indiquent une expression spatiotemporelle différente pour KISS1 et KISS1R entre le 1 er et 3 ème trimestre des grossesses normales. Nous n’avons pas mis en évidence de modulation de l’expression des ARNm dans les grossesses pathologiques. [less ▲]

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See detailActive Foxp3 (+) Regulatory T Cells Rather Than Other Foxp3 (+) T Cells Subsets CorrelateWith Clinical Response To Infliximab Therapy For IBD
Li, Z; Vermeire, S; Bullens, D et al

Poster (2012, October)

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See detailTendinopathies et plasma riche en plaquettes : applications cliniques
Kaux, Jean-François ULg

in 5ème Congrès Commun SFMES & SFTS (2012, October)

Les lésions tendineuses représentent au sein d’une population sportive ou de travailleurs de force une proportion élevée des lésions de surcharge. Leur incidence atteint 30% des pathologies musculo ... [more ▼]

Les lésions tendineuses représentent au sein d’une population sportive ou de travailleurs de force une proportion élevée des lésions de surcharge. Leur incidence atteint 30% des pathologies musculo-squelettiques ; la douleur limite régulièrement les capacités fonctionnelles et athlétiques (1). Actuellement, ces tendinopathies demeurent un défi thérapeutique car certaines évoluent selon un mode désespérément chronique en raison de leur caractère rebelle aux différentes thérapeutiques conservatrices classiques (anti-inflammatoires, rééducation, ondes de choc...). Les infiltrations de plasma riche en plaquettes (PRP) pourraient représenter une alternative espoir thérapeutique suite aux résultats de diverses expérimentations in vitro et animales (2). Les résultats favorables relatés par les médias sportifs contrastent parfois singulièrement avec les études cliniques. Le PRP ne figure plus sur la liste des produits dopants depuis janvier 2011 (www.wada-ama.org) contrairement aux produits sanguins labiles (3).Cette revue actualise le traitement des lésions tendineuses (épicondylite, tendinopathies de coiffe, patellaire et calcanéenne) ainsi que les fasciites plantaires par plasma riche en plaquettes (3). Etant donné le caractère récent de ce traitement dans le domaine médico-sportif, les études cliniques réalisées à ce jour n’ont pas confirmé les effets bénéfiques obtenus in vitro. Certaines études démontrent une amélioration de la symptomatologie suite au traitement par PRP, mais d’autres études apparaissent contradictoires. Cependant, il est communément admis qu’après l’infiltration, une (auto-)rééducation excentrique sous-maximale progressive améliore la qualité de la cicatrisation tendineuse. Le PRP initie un processus cicatriciel, secondairement développé par le vecteur des forces excentriques (4). L’avenir du PRP nécessite une standardisation de la procédure de recueillement permettant d’éviter la collecte des globules rouges et blancs pouvant être délétères au processus cicatriciel (chaque technique produit un PRP différent (5)), ainsi que la réalisation de protocoles standardisés permettant de comparer les futurs travaux. De plus, le type de tendon exercerait-il un effet sur la réponse de guérison ? Celle-ci serait-elle différente entre certains tendons volumineux (calcanéen, patellaire) et les autres (épicondyliens, coiffe des rotateurs...) ? Références: Kaux et al. Current opinion on tendinopathy. Journal of Sports Sciences and Medicine, 2011; 10:238-253. Kaux et al. Effects of platelet-rich plasma (PRP) on the healing of Achilles tendons of rats. Wound Repair and Regeneration, 2012 ; 5: 748-756. Smets et al. Applications cliniques du plasma riche en plaquettes (PRP) dans les lésions tendineuses : revue de la littérature. Science & Sport, 2012; 27:141-153 Kaux et al. Eccentric training improves tendon biomechanical properties: a rat model. Journal of Orthopaedic Research, 2012; DOI: 10.1002/jor.22202 Kaux et al. Etude comparative de cinq techniques de préparation plaquettaire (platelet-rich plasma). Pathologie-Biologie, 2011; 59: 157-160. Plus de références sur orbi.ulg.ac.be [less ▲]

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See detailRADIATION SHIELDING OF COMPOSITE SPACE ENCLOSURES
Atxaga, G.; Marcos, J.; Jurado, M. et al

Conference (2012, October)

Space electronic systems employ enclosures to shield sensitive components from space radiation. The purpose of shielding is to attenuate the energy and the flux of ionizing radiation as they pass through ... [more ▼]

Space electronic systems employ enclosures to shield sensitive components from space radiation. The purpose of shielding is to attenuate the energy and the flux of ionizing radiation as they pass through the shield material, such that the energy per unit mass (or dose) absorbed in silicon is sufficiently below the maximum dose ratings of electronic components. The received radiation amount varies significantly depending on several variables that include mission parameters (orbit, altitude, inclination and duration), spacecraft design (spacecraft wall thickness and panel-enclosure location). To achieve the optimum shielding with the minimum weight, all these variables have to be considered in the design. Energetic particles, mainly electrons and protons, can destroy or cause malfunctions in spacecraft electronics. The standard practice in space hardware is the use of aluminium as both a radiation shield and structural enclosure. Composite structures show potential for significant mass savings. However, conventional graphite epoxy composites are not as efficient shielding materials as aluminium because of their lower density, that is, for the same mass, composites provide 30 to 40% less radiation attenuation than aluminium. A solution is to embed high density (atomic weight) material into the laminate. This material, typically metallic material, can be dispersed in the composite or used as layers in the laminate (foils). The main objective of the “Radiation Shielding of Composite Space Enclosures” (SIDER) project is the development of the technologies and tools required to obtain lightweight, safe, robust and reliable composite structures. Two different strategies are being analysed as alternatives for radiation shielding: and he incorporation of a high density material foil. This paper will present and analyse the radiation shielding obtained by the incorporation of nanomaterials in composite structures. [less ▲]

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See detailEncoded haplotype data as input to ipPCA can better resolve population clustering
Chaichoompu, Kridsadakorn ULg; Pongsakorn, Wangkumhang; Anunchai, Assawamakin et al

Poster (2012, October)

Background Studies in population genetics are mainly based on the analysis of genetic variations among different populations. With the advent of advanced genotyping technology, large number of Single ... [more ▼]

Background Studies in population genetics are mainly based on the analysis of genetic variations among different populations. With the advent of advanced genotyping technology, large number of Single Nucleotide Polymorphisms (SNPs) can be used to capture the underlying population variations. Iterative pruning principal component analysis (ipPCA) is a very powerful tool to cluster subpopulations based on their SNP profiles. However, when several similar populations are considered in the analysis, differentiating these populations can become very challenging. Haplotype has been known to capture more segregation information and higher power than SNP but due to high inference complexity, this concept has not been widely used. Recently, haplotype sharing (HS) was reported as a good alternative method to evaluate variation among populations. HS interrogates the entire genotyping without estimating haplotype block, making it computational efficient, yet retaining population profile. Adopting HS technique and introducing a new haplotype encoding as the input to ipPCA to perform population clustering can yield very good outcomes. Results In this study we transformed an indigenous Thai SNP genotyping data, obtained from Pan Asian SNP consortium, into encoded haplotype profiles. The dataset include 13 indigenous populations (245 individuals) composing of approximately 54K SNPs for each individual. To do this, an encoded haplotype matrix was constructed by inferring overlapping haplotype based on sliding window approach in BEAGLE, an efficient haplotype inference tool. We fed this encoded haplotype matrix to ipPCA to cluster these individuals into sub-groups using only their genetic profiles. We compared the results obtained from standard protocol of ipPCA with the one that use the encoded haplotype matrix in terms of numbers of clustered subpopulations as well as the accuracy to correctly assign an individual to a correct subpopulation. Using the encoded haplotype matrix as input to ipPCA rendered the exact 13 subpopulations to be clustered with 99.18% of individual assignment accuracy, whereas the conventional ipPCA identified only 10 subpopulations with 93.47% of individual assignment accuracy. Conclusions Our result demonstrated the great potential of using the encoded haplotype matrix with ipPCA for population genetics studies. This new protocol can promote the clustering of individuals using only their genetic profiles. [less ▲]

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See detailCharacterization of the resistance of SJL/J mice to pneumonia virus of mice, a model for infantile bronchiolitis due to a respiratory syncytial virus
Glineur, Stéphanie ULg; bui tran anh, dao; Sarlet, Michaël ULg et al

in PLoS ONE (2012), 7(10), 44581

Respiratory syncytial virus (RSV), a prominent cause of airway morbidity in children, maintains an excessive hospitalization rate despite decades of research. Host factors are assumed to influence the ... [more ▼]

Respiratory syncytial virus (RSV), a prominent cause of airway morbidity in children, maintains an excessive hospitalization rate despite decades of research. Host factors are assumed to influence the disease severity. As a first step toward identifying the underlying resistance mechanisms, we recently showed that inbred mouse strains differ dramatically as regards their susceptibility to pneumonia virus of mice (PVM), the murine counterpart of RSV. PVM infection in mice has been shown to faithfully mimic the severe RSV disease in human infants. This study aimed at dissecting the remarkable PVM-resistance shown by the SJL/J strain. To characterize its genetic component, we assessed clinical, physiopathological, and virological resistance/susceptibility traits in large first (F1) and second (F2) generations obtained by crossing the SJL/J (resistant) and 129/Sv (susceptible) strains. Then, to acquire conclusive in vivo evidence in support of the hypothesis that certain radiosensitive hematopoietic cells might play a significant role in PVM-resistance, we monitored the same resistance/susceptibility traits in mock- and γ-irradiated SJL/J mice. Segregation analysis showed that (i) PVM-resistance is polygenic, (ii) the resistance alleles are recessive, and (iii) all resistance-encoding alleles are concentrated in SJL/J. Furthermore, there was no alteration of SJL/J PVM resistance after immunosuppression by γ-irradiation, which suggests that adaptive immunity is not involved. We conclude that host resistance to pneumoviruses should be amenable to genetic dissection in this mouse model and that radioresistant lung epithelial cells and/or alveolar macrophages may control the clinical severity of pneumovirus-associated lung disease. [less ▲]

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See detailEUV high resolution imager on-board Solar Orbiter: optical design and detector performances.
Halain, Jean-Philippe ULg; Mazzoli, Alexandra ULg; Rochus, Pierre ULg et al

Poster (2012, October)

The EUV high resolution imager (HRI) channel of the Extreme Ultraviolet Imager (EUI) on-board Solar Orbiter will observe the solar atmospheric layers at 17.4 nm wavelength with a 200 km resolution. The ... [more ▼]

The EUV high resolution imager (HRI) channel of the Extreme Ultraviolet Imager (EUI) on-board Solar Orbiter will observe the solar atmospheric layers at 17.4 nm wavelength with a 200 km resolution. The HRI channel is based on a compact two mirrors off-axis design. The spectral selection is obtained by a multilayer coating deposited on the mirrors and by redundant Aluminum filters rejecting the visible and infrared light. The detector is a 2k x 2k array back-thinned silicon CMOS-APS with 10 µm pixel pitch, sensitive in the EUV wavelength range. Due to the instrument compactness and the constraints on the optical design, the channel performance is very sensitive to the manufacturing, alignments and settling errors. A trade-off between two optical layouts was therefore performed to select the final optical design and to improve the mirror mounts. The effect of diffraction by the filter mesh support and by the mirror diffusion has been included in the overall error budget. Manufacturing of mirror and mounts has started and will result in thermo-mechanical validation on the EUI instrument structural and thermal model (STM). Because of the limited channel entrance aperture and consequently the low input flux, the channel performance also relies on the detector EUV sensitivity, readout noise and dynamic range. Based on the characterization of a CMOS-APS back-side detector prototype, showing promising results, the EUI detector has been specified and is under development. These detectors will undergo a qualification program before being tested and integrated on the EUI instrument. [less ▲]

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See detailL’État et la gestion de la grippe A(H1N1)
Rossignol, Nicolas ULg; Thoreau, François ULg

in Revue Nouvelle (2012), 10

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See detailStudy of the Boettcher cells along their development: Junctions and expression of the urea-transporter B (UT-B)
Cloes, Marie ULg; Renson, Thomas; Johnen, Nicolas ULg et al

Poster (2012, September 30)

The Boettcher cells (BC) lie on the sensory epithelium of the cochlea. Their function has never been clearly defined. However it has been suggested that they may influence the ionic composition of the ... [more ▼]

The Boettcher cells (BC) lie on the sensory epithelium of the cochlea. Their function has never been clearly defined. However it has been suggested that they may influence the ionic composition of the fluids of the inner ear, which play a central role in the conduction of the sensory information. In this context the compartimentating function of the BC around and after the onset of hearing may influence the subsequent refining of hearing. We collected ultrastructural and immunohistological data during the final maturation stage of the sensory epithelium. In particular the cell junctions were investigated to clarify the compartimentating function of the BC at early stages. As a potential actor in the ion flow in the sensory epithelium, the urea transporter-B (UT-B) was also immunolocalised during the development of the BC. At the mature stage (P25) the BC are linked to the adjacent cells by numerous adherens and non-adherens junctions. They rest on a basilar membrane to which they are attached by hemidesmosomes. They typically exhibit large basolateral interdigitations. We found that, at the 8th postnatal day, the BC are separated from the neighbouring cells by wide spaces entered by scarce cytoplasmic extensions. These spaces are interrupted by areas of close contact, where adherens and non-adherens junctions may be found. Thus, although there seems to be fewer interdigitations at P8, gap junctions probably still allow easy cell-to-cell exchanges. Moreover non-adherens junctions can systematically be identified apically. Although it was impossible to differenciate tight and gap junctions without specific labeling, we postulate that these non-adherens junctions correspond to tight junctions and seal the apex of the BC. This feature is necessary to enable the control of the ion concentrations surrounding the sensory epithelium. We also found that UT-B, known for water and urea transport in red blood cells, is present in the membranes of the BC from P12 (the earliest stage tested) to P25. Thus UT-B may play a role in the regulation of the ionic concentrations of the inner ear fluids. [less ▲]

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See detailWhen should we measure Vitamin D in Clinical Practice
CAVALIER, Etienne ULg

Conference (2012, September 29)

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See detailAbout the diagnosis of acute transfusion-related reaction during cardiopulmonary bypass
ERPICUM, Marie ULg; BLAFFART, Francine ULg; DEFRAIGNE, Jean ULg et al

Conference (2012, September 29)

Many advances have been realized in the field of blood safety during the last decade: donors’ selection, leukoreduction of packed red blood cells and platelet concentrates, genomic screening of blood ... [more ▼]

Many advances have been realized in the field of blood safety during the last decade: donors’ selection, leukoreduction of packed red blood cells and platelet concentrates, genomic screening of blood-borne diseases, viral and bacterial inactivation process,... However, transfusion of blood components remains unsafe. Therefore, detecting and reporting transfusion-related complications are still essential means for both the patients’ management and the public health approach, since these measures help to adjust preventive measures to be applied in a haemovigilance purpose. Most acute transfusion-related complications occur within minutes or hours after transfusion and require urgent medical care; delayed transfusion reactions may also develop days, even months later, implying a longer follow-up. Transfusion of red blood cells is not infrequent during cardiac surgery with cardiopulmonary bypass. Symptoms of acute transfusion-related reactions include hypotension, diffuse bleeding, hemoglobinuria and oliguria. These symptoms are identical to those that can be observed during a complicated cardiopulmonary bypass. Consequently, identification of acute transfusion-related reactions in this particular situation is quite difficult and probably leads to an under-reporting of their occurrence. In this paper, we explore how to track acute transfusion-related reactions during cardiopulmonary bypass. Any suspicion of such reactions must leads to investigations, in order to confirm the diagnosis. Their detection would allow to better focus their specific treatment and further their notification in a global blood safety policy. [less ▲]

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See detailHjelmslev's notion of "Participation"
Cigana, Lorenzo ULg

Conference (2012, September 29)

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See detailPostoperative bleeding and autotransfusion
ERPICUM, Marie ULg; BLAFFART, Francine ULg; DEFRAIGNE, Jean ULg et al

Poster (2012, September 29)

Introduction: Bleeding in the postoperative period of cardiac surgery is not infrequent. Mediastinal bleeding is usually collected in a chest drainage system and discarded. Nevertheless, this blood could ... [more ▼]

Introduction: Bleeding in the postoperative period of cardiac surgery is not infrequent. Mediastinal bleeding is usually collected in a chest drainage system and discarded. Nevertheless, this blood could potentially be managed with a cell salvage device during the first six postoperative hours. This practice is generally performed only in case of a surgical re-exploration for massive bleeding and may contribute to decreased allogeneic transfusion. But in case of postoperative coagulopathy requiring medical treatment, re-exploration is usually postponed and consequently, collected blood is discarded. Therefore, chest drainage systems combined with a cell salvage option could optimize the management of blood losses and transfusions in the postoperative period, regardless of any surgical re-exploration. The aim of this study is to assess the effectiveness of such a system during the postoperative period of cardiac surgery, in patient at high risk of bleeding. Method : During a 6 months period, the CardioPAT® (Haemonetics) device was used in all cardiac surgery patients at high risk of postoperative bleeding. The following data were prospectively collected: hemoglobin level, bleeding volume, volume of autologous washed red blood cell transfused by the CardioPAT® (WRBC), volume of allogeneic red blood cell (RBC), fresh frozen plasma (FFP) or platelets (PT) transfused and surgical re-exploration. Results : The CardioPAT® was used in 16 patients during the target period. Mean postoperative bleeding volume was 338±337mL after 1 hour and 820±727mL after 6 hours. The cell salvage option was used in 9 (56%) cases and mean WRBC transfused volume was 153±212mL. One patient required surgical re-exploration. All patients transfused by WRBC received previously an allogeneic transfusion (RBC, FFP and/or PT). The hemoglobin level of blood collected in the CardioPAT® device impacted on the delay and the blood volume required for WRBC availability; lower was the hemoglobin level, larger was the volume of blood required to obtain a concentrate of WRBC. Consequently, patients with a very low hemoglobin level were anyway transfused with RBC. Conclusion : The CardioPAT® device can reduce allogeneic blood transfusion after cardiac surgery in patients at high risk of bleeding. It gives time to treat coagulopathy, leading to a decrease of surgical re-exploration. However, a device with a larger reservoir and with a flexible processing speed would be more accurate in case of major haemorrhage. Systematic utilisation of this device at the time of FFP and/or PT transfusion is a safe but expensive strategy. It seems more accurate to use this device in a permissive bleeding strategy, waiting for the spontaneous coagulation recovery of the patient, in the first postoperative hours. [less ▲]

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See detailCardiac surgery and acute kidney injury: retrospective study
LAGNY, Marc-Gilbert ULg; BLAFFART, Francine ULg; Defraigne, Jean-Olivier ULg et al

Conference (2012, September 29)

Background: In cardiac surgery, acute kidney injury (AKI) is a severe postoperative complication and associated with increased rates of mortality, morbidity, and length of stay in intensive care units ... [more ▼]

Background: In cardiac surgery, acute kidney injury (AKI) is a severe postoperative complication and associated with increased rates of mortality, morbidity, and length of stay in intensive care units (ICU). It occurs in 5% to 30% of patients depending on the definition used [1] [2] [3]. The aim of this study is to present an overview of AKI following cardiac surgery associated or not with cardiopulmonary bypass. Methods: This retrospective study includes patients treated by cardiac surgery from April 1st, 2008 to March 31th, 2009 in a single center. We selected patients who underwent on-pump coronary artery bypass surgery (CABG), off-pump CABG (OPCAB), aortic valve replacement, mitral valve repair or replacement and aortic valve replacement combined with CABG. Patients undergoing renal replacement therapy preoperatively were excluded. The RIFLE classification (Risk, Injury, Failure, Loss and End stage kidney disease) allowed to stratify the patients into the 3 grades of AKI severity. The stratification was based on the most pejorative element observed within 7 days after surgery: increased serum creatinine level or decreased urine output, or decreased glomerular filtration rate according to criteria of Bellomo [4]. Occurrence of AKI was studied by type of cardiac surgery as its impact on the length of stay in ICU and in the hospital. Proportions were compared by the Chi-square test and median values by the Kruskal-Wallis. Results were considered significant at p < 0.05. Results: Four hundred and thirty four patients were included: median (IQR) age 69.0(60.0-76.0) year, 30.2% females, 2.76% urgent/emergent cases. Fifty-eight patients (13.4%) underwent OPCAB, 182(41.9%) on-pump CABG, 104(24.0%) aortic valve replacement, 44(10.1%) mitral valve repair or replacement and 46(10.6%) aortic valve replacement combined with CABG. AKI occurred in 213(49.1%) patients: 79(37.1%) “Risk”, 108(50.7%) “Injury” and 26(12,2%) “Failure”. Occurrence of AKI after OPCAB was 21(9.86%), CABG 80(37.6%), aortic valve replacement 51(23.9%), mitral valve surgery 23(10.8%) and aortic valve replacement combined with CABG 38(17.8%). AKI occurrences differed significantly between the different groups of surgery (p<0.0001). Lengths of stay in ICU were significantly longer (p<0.0001) in AKI group compared with non AKI group: 3(2-4) days versus 2(2-3) days. No difference (p = 0.65) was observed between the two (AKI and NON-AKI) groups in hospital length of stay: 13(10-18) days versus 12(10-16) days. Conclusions: The incidence of AKI is very high in this population as compared to the literature. This may be due to the fact that the three elements of the RIFLE classification for all the population studied have been used: serum creatinine level, urine output and glomerular filtration rate. This study emphasizes the need for clear definition of AKI in order to compare adequately different studies. AKI after cardiac surgery with cardiopulmonary bypass would be further studied in order to develop more appropriate preventive measures. [less ▲]

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