References of "2012"
     in
Bookmark and Share    
See detailHuman papillomavirus capsids trigger crosstalk between dendritic and NK cells
Langers, Inge ULg; Renoux, Virginie; Pirotte, Evelyne et al

Poster (2012, September 26)

The immune system controls, at least partially, human papillomavirus (HPV) infection and subsequent tumour development as demonstrated by a higher tumour prevalence in immunodeficient patients. More than ... [more ▼]

The immune system controls, at least partially, human papillomavirus (HPV) infection and subsequent tumour development as demonstrated by a higher tumour prevalence in immunodeficient patients. More than 90% of HPV-infected women will clear the virus within two years. However, it remains unclear which immune cells are implicated in this process and although dendritic cells (DC) and NK cells play a key role in host resistance to virus and tumour, no study has been performed evaluating their crosstalk in this context. Virus-like particles (VLP) formed by the HPV major capsid protein L1 are licensed as vaccine against cervical cancer and we have recently shown that NK cells can directly interact with these HPV-VLP [1]. Here, we investigated the impact of this activation on NK-DC crosstalk. Interestingly, NK cells increase DC maturation induced by HPV-VLP as shown by an up-regulation of HLA-DR and CD86 on DC. Transwell experiments indicated that the expression of HLA-DR is cell-cell contact and soluble factor dependent, whereas only soluble factors seem to be required for CD86 expression. Moreover, in the presence of HPV-VLP and NK cells, DC produce higher amounts of IL12p70, while the production of the immunosuppressive cytokine IL10 remains unchanged. We also demonstrated that DC can up-regulate the expression of NK activation markers (CD69 and HLA-DR) in the presence of HPV-VLP. This up-regulation requires both cell-cell contact and soluble factors. Regarding HLA-DR marker, the increased expression on CD56bright cells is mediated by soluble factors, whereas cell-cell contacts are also important for HLA-DR expression on CD56dim cells. In the presence of DC activated by HPV-VLP, the function of NK cells is also modified since they become more cytotoxic against HPV+ cell line and secrete more IFN-γ. Our results suggest that NK-DC crosstalk could play a role in the immune response induced by HPV-VLP during vaccination protocols against cervical cancer. [less ▲]

Detailed reference viewed: 21 (5 ULg)
Full Text
See detailLes iguanodons de Bernissart: leur évolution diagénétique et les processus de dégradation
Leduc, Thierry ULg

Doctoral thesis (2012)

About thirty complete articulated skeletons of iguanodons have been excavated from Bernissart. This unique collection is conserved at the RBINS. The bones excavated were the object of diverse physical and ... [more ▼]

About thirty complete articulated skeletons of iguanodons have been excavated from Bernissart. This unique collection is conserved at the RBINS. The bones excavated were the object of diverse physical and chemical treatments to protect them from their degradation. These bones were not the object of detailed mineralogical analyses allowing to understand either diagenetic mechanisms involved or to understand the specific mechanisms of their change. This work thus aims at filling this lack. It integrates petrographic (POM, SEM), mineralogical (DRX, Raman Spectroscopy) and chemical (EDS, X-ray fluorescence, microprobe) techniques. By these methods, 30 different minerals were identified. The diagenesis of Iguanodon bones is the result of cumulative physical, chemical and biological processes that will modify the original chemical and/or structural properties of this organic object. Bone diagenesis is a complex process that includes the degradation of organic matter, the dissolution and recrystallization of bone apatite, the enrichment in trace elements, the precipitation of new minerals in the bone cavities (permineralisation), the fracturation process. A plan is proposed positioning in a relative timescale minerals formed during 3 diagenetic stages and the degradation processes engaged following the bones exhumation. During burial variable recrystallisation took place: the slightly crystallized carbonated hydroxylapatite (the mineral phase of fresh bone tissue) was replaced by well crystallized carbonated fluorapatite currently present in the Iguanodon bones. Whereas some minerals infiltrated in the bone during cavity filling by the sediment (“mainly” quartz, “argillaceous” phyllosilicates), others are authigenic and precipitated in the cavities during burial (pyrite, barite, sphalerite, celestine, iron oxi-hydroxides, authigenic apatite, calcium sulfate and to a lesser extent vivianite). Pyrite is the most abundant authigenic mineral in the Iguanodon fossil bones. It occurs in different morphologies (crystals, framboids, sticks, fibroradial structure, thin coating…). Four kind of pyrite were determined according to the diagenesis phase during which they were formed and the source of iron and sulfur. Besides pyrite barite is the second most abundant phase. When both minerals are present pyrite has been formed first. The distribution of these minerals within bones is more controlled by micro-environments than by particular structure of the bone. Since their discovery the Iguanodon fossil bones were treated for conservation in several ways. This however did not prevent the alteration of pyrite into an assemblage of 16 different secondary minerals. The ferrous sulfates (szomolnokite and rozenite) are the most abundant of these minerals and can be found in nearly all samples sulfatized. Other sulfates were formed as the result of alteration of the wealdian shale by acid produced by pyrite oxidation: e.g. tschermigite, natrojarosite and halotrichite. Gypsum, anhydrite, iron phosphate and diadochite are the result of dissolution of bone apatite. The variations of relative humidity in collections and in showrooms are responsible for the pursuit of the bones degradation (sulfatation of the residual sulfides ; fracturing by dilation / contraction). The relative humidity, conjugated to the temperature variations are the parameters to be controlled for a better preservation of these invaluable fossils. Techniques implementing some chemicals products proposed in the literature are applicable only to certain objects of limited size. [less ▲]

Detailed reference viewed: 73 (13 ULg)
Full Text
Peer Reviewed
See detailThe applications of biodegradable polymers for drug delivery and tissue engineering
Grandfils, Christian ULg

in Proceeding XVI International School for Junior Scientists and Students on Optics, Laser Physics & Biophotonics (2012, September 25)

Detailed reference viewed: 5 (3 ULg)
Peer Reviewed
See detailL’énonciation vidéoludique : analyse du jeu Portal
Barnabé, Fanny ULg

Conference (2012, September 25)

Cette présentation s'intéresse aux particularités énonciatives du jeu vidéo en mettant à profit les outils développés par la sémiotique visuelle et en prenant appui sur l'analyse d'une oeuvre spécifique ... [more ▼]

Cette présentation s'intéresse aux particularités énonciatives du jeu vidéo en mettant à profit les outils développés par la sémiotique visuelle et en prenant appui sur l'analyse d'une oeuvre spécifique: le jeu "Portal" (Valve Software, 2007). [less ▲]

Detailed reference viewed: 54 (10 ULg)
Full Text
See detailThe Giant Raman Scattering Platforms on the Basis of Core-Shell Miscrostructures Containing Astralene Nanoparticles and Their Application for Detection of Bioactive Molecules
Stetciura, I.Y.; Markin, A.V.; Ponomarev, A.N. et al

in Proceeding of XVI International School for Junior Scientists and Students on Optics, Laser Physics & Biophotonics (2012, September 25)

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailSustainability Performance Management in Large Firms: A Qualitative Research amongst Seven Large Western European Firms
Crutzen, Nathalie ULg

Conference (2012, September 25)

The aim of this paper is to understand better sustainability performance management in large firms. Based on previous research in this field, this paper reports the results of a qualitative research ... [more ▼]

The aim of this paper is to understand better sustainability performance management in large firms. Based on previous research in this field, this paper reports the results of a qualitative research amongst seven large Western European firms. This research examines why and how these large firms manage their sustainability performance. [less ▲]

Detailed reference viewed: 69 (6 ULg)
Full Text
See detailBiologie et Ecologie du Martin- pêcheur huppé (Alcedinidae : Alcedo cristata, PALLAS 1764) de la région de Kinshasa: habitat, tactique alimentaire et reproduction.
Kisasa Kafutshi, Robert ULg

Doctoral thesis (2012)

Pour expliquer la rareté de sites de nidification du Martin-pêcheur huppé dans la région de Kinshasa, trois hypothèses ont été successivement testées au cours de ce travail. Une première hypothèse ... [more ▼]

Pour expliquer la rareté de sites de nidification du Martin-pêcheur huppé dans la région de Kinshasa, trois hypothèses ont été successivement testées au cours de ce travail. Une première hypothèse suggérait que le choix de son habitat de reproduction résulterait d’un compromis entre le taux de survie de ses nids, de son succès reproducteur et de la qualité des sols utilisés pour la construction des nids. Le résultat obtenu a révélé qu’un sol propice à l’excavation est constitué de 10,8 ± 6,1% de limon, 7,5 ± 6,6% d’argile et de 81,4 ± 11,4% de sable. Par contre les falaises dont les sols sont constitués en moyenne de 8,5±5,6% de limon ; 11,6±6,5% d’argile et de 78,9±13% de sable, étaient soit abandonnées, soit non occupées. Il semble que la teneur en argile pour un sol favorable chez la plupart des oiseaux nichant dans le terrier est généralement inférieure à 10%. Une différence d’environ 1% de teneur en argile, en comparaison avec les falaises abandonnées ou sans nids dans la région, nous a paru inconcevable pour relier l’absence des nids dans certains habitats naturels avec la dureté des sols. La seconde hypothèse confirme le rôle de la relation structure fonction à partir des suivis réguliers de 138 poussins de l’éclosion à la sortie des nids. Le résultat obtenu montre que la croissance et le développement des organes expliquent le patron de consommation de l’espèce et les paramètres plus ou moins importants à la survie de l’espèce en milieux urbanisés (Kisasa Kafutshi sous presse). Et enfin, la troisième hypothèse suggère que le choix de proies à capturer par les adultes dépendrait des exigences des poussins et leur disponibilité dans le site. Pour toute la durée d’élevage, la consommation d’une nichée a été estimée à environ 17 proies. Il s’agissait des insectes, des grenouilles et de poissons de tailles variant de 2-6,5cm. Nous avons montré que le Martin-pêcheur huppé module le choix de son habitat de reproduction non seulement en fonction de la texture du sol des falaises (Kisasa Kafutshi & Aloni Kumanda 2011), de la disponibilité des proies (Kisasa Kafutshi 2012a), mais surtout de la chance de survie de ses nids d’une année à l’autre (Kisasa Kafutshi 2012b). [less ▲]

Detailed reference viewed: 74 (5 ULg)
Full Text
See detailThe applications of biodegradable polymers for drug delivery and tissue engineering
Grandfils, Christian ULg

in Smart nanocomposite scaffold for tissue engineering (2012, September 25)

Detailed reference viewed: 19 (1 ULg)
Full Text
See detailLa répétition comme fond ou comme figure : une étude de cas
Lindenberg Lemos, Carolina ULg

Conference (2012, September 25)

While addressing the matter of the effects of tension produced by repetitive elements in texts, we came across the question of the level of pertinence where such effects would arise. After a brief ... [more ▼]

While addressing the matter of the effects of tension produced by repetitive elements in texts, we came across the question of the level of pertinence where such effects would arise. After a brief investigation of linguistic levels (sounds, words, phrases, sentences) and of semiotic levels (figures, themes, motifs, narrative structures), this approach proved to be of little consequence, seeing as it is possible to find, in each level, examples of repetitions that are relevant and that are irrelevant for the effects under study. Borrowed from the Gestalt theory and the more recent developments in Cognitive Linguistics, the concepts of figure and ground may serve as tools in the research. The level of pertinence is then established through relations, i.e. it is subject to the relative position of the repetitive elements in the whole of the text, as well as in its combination with the other parts of the text. Français : À partir de l'étude des effets de tension produits par les éléments répétitifs dans les textes, la question se pose à propos du niveau de pertinence où ces effets sont ressentis. Cependant, après une brève investigation des niveaux linguistiques (sons, mots, syntagmes, phrases) et des niveaux sémiotiques (figures, thèmes, motifs, structures narratives), la question se trouve dénuée de conséquence, vu qu'il est possible de trouver des répétitions et pertinentes et non pertinentes à chaque niveau. Pour avancer sur ce point, les concepts de fond et figure, empruntés de la théorie de la Gestalt et des nouveaux développements de la Linguistique Cognitive, peuvent servir d'outils. La pertinence de la répétition s’établit alors de manière relationnelle, c'est-à-dire en fonction de la position relative des éléments répétitifs dans le tout et par rapport aux autres parties du texte. [less ▲]

Detailed reference viewed: 31 (2 ULg)
See detailCommunication intitulée « Migration, Citoyenneté et Diversité Culturelle en Europe »
Martiniello, Marco ULg

Scientific conference (2012, September 25)

Detailed reference viewed: 7 (4 ULg)
See detailLe métier de gestionnaire de recherche
Jeandrain, Denys ULg

Conference (2012, September 25)

Detailed reference viewed: 19 (9 ULg)
Full Text
See detailLa biblioteca de La Nación
Willson, Patricia ULg

Article for general public (2012)

Detailed reference viewed: 12 (4 ULg)
See detailDiscussion on "Recapturing the Reluctant Radical. How to win back Europe’s populist vote"
Jamin, Jérôme ULg

Conference given outside the academic context (2012)

Detailed reference viewed: 10 (1 ULg)
See detailFORMATION: "Le soutien aux aidants des patients souffrant de pathologies démentielles"
Adam, Stéphane ULg

Conference given outside the academic context (2012)

Detailed reference viewed: 21 (1 ULg)