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See detailIn Vivo Tumorigenesis Was Observed after Injection of In Vitro Expanded Neural Crest Stem Cells Isolated from Adult Bone Marrow
Wislet, Sabine ULg; Poulet, Christophe ULg; Neirinckx, Virginie ULg et al

in PLoS ONE (2012), 7(10), 46425

Bone marrow stromal cells are adult multipotent cells that represent an attractive tool in cellular therapy strategies. Several studies have reported that in vitro passaging of mesenchymal stem cells ... [more ▼]

Bone marrow stromal cells are adult multipotent cells that represent an attractive tool in cellular therapy strategies. Several studies have reported that in vitro passaging of mesenchymal stem cells alters the functional and biological properties of those cells, leading to the accumulation of genetic aberrations. Recent studies described bone marrow stromal cells (BMSC) as mixed populations of cells including mesenchymal (MSC) and neural crest stem cells (NCSC). Here, we report the transformation of NCSC into tumorigenic cells, after in vitro long-term passaging. Indeed, the characterization of 6 neural crest-derived clones revealed the presence of one tumorigenic clone. Transcriptomic analyses of this clone highlighted, among others, numerous cell cycle checkpoint modifications and chromosome 11q down-regulation (suggesting a deletion of chromosome 11q) compared with the other clones. Moreover, unsupervised analysis such as a dendrogram generated after agglomerative hierarchical clustering comparing several transcriptomic data showed important similarities between the tumorigenic neural crest-derived clone and mammary tumor cell lines. Altogether, it appeared that NCSC isolated from adult bone marrow represents a potential danger for cellular therapy, and consequently, we recommend that phenotypic, functional and genetic assays should be performed on bone marrow mesenchymal and neural crest stem cells before in vivo use, to demonstrate whether their biological properties, after ex vivo expansion, remain suitable for clinical application. [less ▲]

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See detailQTL mapping and candidate gene research for the phenolic content of fruits and juices prepared from a cider apple progeny
Verdu, Cindy ULg; Guyot, Sylvain; Childebrand, Nicolas et al

Poster (2012, October)

Polyphenols have favorable antioxidant potential on human health suggesting that their high content in apple is responsible for the beneficial effects of apple consumption. They are also related to the ... [more ▼]

Polyphenols have favorable antioxidant potential on human health suggesting that their high content in apple is responsible for the beneficial effects of apple consumption. They are also related to the quality of ciders as they predominantly account for astringency, bitterness, color and aroma. Five groups of phenolic compounds are described in the apple fruit: flavanols, hydroxycinnamic acids, dihydrochalcones, flavonols and anthocyanins. So far, only two studies have been published on the genetic basis of the phenolic content of dessert apples. As cider apples are commonly described to be much more concentrated in phenolic compounds than dessert varieties, the present study focuses on a cider apple progeny. 32 compounds belonging to the five groups were identified and quantified by HPLC-UV and UHPLC-UV-MS/MS in fruit extracts and juices. 53 QTL controlling phenolic compounds concentration were detected on nine linkage groups (LG) on the integrated linkage map, for all phenolic groups except anthocyanins. QTL clusters located on LG1, 12, 14, 15 and 17 were stable across the year or the studied material. QTL detected on LG1, 14 and 17 for quercitrin, p-coumaroylquinic acid, rutin and chlorogenic acid confirmed results of previous studies. However, no significant QTL was obtained on the LG16 where a major locus for flavanols was previously located. With the two previous studies, this study shows the diversity of genomic regions controlling traits of interest in apple. [less ▲]

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See detailEffect of finger tapping frequency on abnormal subthalamic nucleus oscillations in Parkinson’s disease
Stamatakis, Julien; Noirhomme, Quentin ULg; Orban, Jonhatan et al

Poster (2012, October)

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See detailLes spécificités de la gestion d'une maison de luxe : vers une modélisation atemporelle de la performance
Riguelle, France ULg; Van Caillie, Didier ULg

in AIREPME (Ed.) Actes du CIFEPME 2012 (2012, October)

Le but ultime de la présente recherche est de modéliser la performance des maisons de luxe de manière transversale (nous décidons de ne pas privilégier l’approche marketing comme une grande partie de la ... [more ▼]

Le but ultime de la présente recherche est de modéliser la performance des maisons de luxe de manière transversale (nous décidons de ne pas privilégier l’approche marketing comme une grande partie de la littérature dédiée à la gestion des métiers du luxe) et atemporelle. Nous proposons d’organiser, au travers du Prime de la Performance (Neely, Adams et Kennerley, 2002), les FCS dont la mise en œuvre permet d’atteindre la performance globale. Cette recherche constitue donc un premier pas vers une modélisation de la performance de la maison de luxe. [less ▲]

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See detailTHE POTENTIAL USE OF NEAR-INFRARED SPECTROSCOPY FOR THE QUALITY ASSESSMENT OF EGGS AND EGG PRODUCTS
GALIŞ, Anca; Dale, Laura ULg; Boudry, Christelle ULg et al

in Scientific Works. C Series. Veterinary Medicine (2012), LVIII(3), 294-307

In a context of high productivity, eggs’ quality assessment is necessary for enhanced safety and quality assurance towards the consumers and feedback for producers. The quality assessment of eggs and egg ... [more ▼]

In a context of high productivity, eggs’ quality assessment is necessary for enhanced safety and quality assurance towards the consumers and feedback for producers. The quality assessment of eggs and egg products is performed using destructive and time-consuming methods, therefore the use of rapid tools becomes mandatory, especially in the case of a high production rate. Near Infrared (NIR) spectroscopy is considered a very reliable and rapid technique with large use in food industry. At the farm level, NIR spectroscopy technique would be an interesting tool to determine the chemical and physical properties of eggs, eggshell and internal quality and, moreover, this information may help the layer farm manager when a problem occurs in the flock. Its application in the egg industry is aimed at the quality changes in eggs during storage and quality assessment of the egg products, through the compositional analysis. It is possible and in some cases successful the prediction and/or determination of different parameters such as: protein, total lipid and total solids content (for liquid egg products), polyunsaturated fatty acids (for freeze-dried egg yolk), moisture, fat and protein content (for spray-dried whole eggs). In addition, for the white colored shell eggs, the detection of blood and meat spots is also successful. Further studies with NIR and near infrared hyper spectral imaging system (NIR-HSI) are needed in this direction, as the results obtained until now are very promising for the development of a rapid tool for quality assessment of eggs and egg products. [less ▲]

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See detailLiège 2017: Connectez-vous
Brandt, Céline ULg

Article for general public (2012)

Le comité de Liège Expo 2017 a pris le parti de faire de la connectivité sa thématique phare: 4 scientifiques s'expriment au sujet de la connectivité.

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See detailAnalyse préalable à une infrastructure de données au Maroc
Ibannain, Fatiha; Donnay, Jean-Paul ULg

in Billen, Roland; Binard, Marc; Hallot, Pierre (Eds.) et al Actes de la conférence internationale de Géomatique et Analyse Spatiale 2012 (2012, October)

In this paper, we discuss ways of promoting a spatial data infrastructure (SDI). Further considerations regulating the organizational infrastructure, the development of tools and models taking into ... [more ▼]

In this paper, we discuss ways of promoting a spatial data infrastructure (SDI). Further considerations regulating the organizational infrastructure, the development of tools and models taking into account the diversity of actors is inevitable to achieve the objectives of an SDI. Our study focused on the technical prerequisites for the establishment of an SDI in Morocco. An ontological approach to the reference spatial data has facilitated the definition of object types when cataloging reference entities, as well the concepts used in conceptual modeling. A feature catalog complying with ISO 19110 is developed using the principles of this ontology illustrating the independence and complementarity of object types, their adaptability to specific application domains and their inheritance. This approach allows establishing a reference model, that is to say a base structure which can be adapted to a wide range of applications. Developments of this work aim to sensitize policy makers about the introduction of an SDI in Morocco. [less ▲]

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See detailCharacterisation of pregnancy losses after embryo transfer by measuring plasma progesterone and bovine pregnancy-associated glycoprotein-1 concentrations
Breukelman, S. P.; Perényi, Z.; Taverne, M. A. M. et al

in Veterinary Record : Journal of the British Veterinary Association (2012), 194(1), 71-76

The aim of this analysis was to determine whether pregnancy loss (PL) after embryo transfer (ET) in cattle was related to maternal progesterone (P4) concentrations during and shortly after ET, and ... [more ▼]

The aim of this analysis was to determine whether pregnancy loss (PL) after embryo transfer (ET) in cattle was related to maternal progesterone (P4) concentrations during and shortly after ET, and maternal bovine pregnancy-associated glycoprotein-1 (bPAG-1) concentrations in plasma at days 25–35 of gestation. Embryos (n = 260) were produced either in vivo after superovulation (n = 115), or in vitro from oocytes (obtained with ovum pick-up) in co-culture (n = 44) or cultured in a synthetic medium (n = 101). Overall, PL was 56.9% (148) and no significant differences occurred in calving rate among the three embryo production groups. There was no difference in P4 concentrations on days 7–14 of gestation in the three groups, nor between ongoing and interrupted pregnancies. Between days 25 and 35 of pregnancy, bPAG-1 concentrations were unaffected by embryo production, but in cattle that had PL between days 26 and 120, four bPAG-1 profiles could be detected. Between days 25 and 32, bPAG-1 concentrations were influenced by PL, and concentrations were significantly lower in animals in which PL occurred between days 26 and 120 than in those animals that aborted later or calved at term. Early P4 concentrations suggested that maternal luteal factors were not responsible for PL which appeared to be caused by impaired conceptus development (regardless of embryo type) as reflected by low maternal bPAG-1 concentrations prior to embryonic death [less ▲]

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See detailGenetic variation in PLAG1 associates with early life body weight and peripubertal weight and growth in Bos taurus.
Littlejohn, M.; Grala, T.; Sanders, K. et al

in Animal Genetics (2012), 43(5), 591-4

Variation at the pleiomorphic adenoma gene 1 (PLAG1) locus has recently been implicated in the regulation of stature and weight in Bos taurus. Using a population of 942 outbred Holstein-Friesian dairy ... [more ▼]

Variation at the pleiomorphic adenoma gene 1 (PLAG1) locus has recently been implicated in the regulation of stature and weight in Bos taurus. Using a population of 942 outbred Holstein-Friesian dairy calves, we report confirmation of this effect, demonstrating strong association of early life body weight with PLAG1 genotype. Peripubertal body weight and growth rate were also significantly associated with PLAG1 genotype. Growth rate per kilogram of body weight, daily feed intake, gross feed efficiency and residual feed intake were not significantly associated with PLAG1 genotype. This study supports the status of PLAG1 as a key regulator of mammalian growth. Further, the data indicate the utility of PLAG1 polymorphisms for the selection of animals to achieve enhanced weight gain or conversely to aid the selection of animals with lower mature body weight and thus lower maintenance energy requirements. [less ▲]

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See detailTendinopathies et plasma riche en plaquettes : applications cliniques
Kaux, Jean-François ULg

in 5ème Congrès Commun SFMES & SFTS (2012, October)

Les lésions tendineuses représentent au sein d’une population sportive ou de travailleurs de force une proportion élevée des lésions de surcharge. Leur incidence atteint 30% des pathologies musculo ... [more ▼]

Les lésions tendineuses représentent au sein d’une population sportive ou de travailleurs de force une proportion élevée des lésions de surcharge. Leur incidence atteint 30% des pathologies musculo-squelettiques ; la douleur limite régulièrement les capacités fonctionnelles et athlétiques (1). Actuellement, ces tendinopathies demeurent un défi thérapeutique car certaines évoluent selon un mode désespérément chronique en raison de leur caractère rebelle aux différentes thérapeutiques conservatrices classiques (anti-inflammatoires, rééducation, ondes de choc...). Les infiltrations de plasma riche en plaquettes (PRP) pourraient représenter une alternative espoir thérapeutique suite aux résultats de diverses expérimentations in vitro et animales (2). Les résultats favorables relatés par les médias sportifs contrastent parfois singulièrement avec les études cliniques. Le PRP ne figure plus sur la liste des produits dopants depuis janvier 2011 (www.wada-ama.org) contrairement aux produits sanguins labiles (3).Cette revue actualise le traitement des lésions tendineuses (épicondylite, tendinopathies de coiffe, patellaire et calcanéenne) ainsi que les fasciites plantaires par plasma riche en plaquettes (3). Etant donné le caractère récent de ce traitement dans le domaine médico-sportif, les études cliniques réalisées à ce jour n’ont pas confirmé les effets bénéfiques obtenus in vitro. Certaines études démontrent une amélioration de la symptomatologie suite au traitement par PRP, mais d’autres études apparaissent contradictoires. Cependant, il est communément admis qu’après l’infiltration, une (auto-)rééducation excentrique sous-maximale progressive améliore la qualité de la cicatrisation tendineuse. Le PRP initie un processus cicatriciel, secondairement développé par le vecteur des forces excentriques (4). L’avenir du PRP nécessite une standardisation de la procédure de recueillement permettant d’éviter la collecte des globules rouges et blancs pouvant être délétères au processus cicatriciel (chaque technique produit un PRP différent (5)), ainsi que la réalisation de protocoles standardisés permettant de comparer les futurs travaux. De plus, le type de tendon exercerait-il un effet sur la réponse de guérison ? Celle-ci serait-elle différente entre certains tendons volumineux (calcanéen, patellaire) et les autres (épicondyliens, coiffe des rotateurs...) ? Références: Kaux et al. Current opinion on tendinopathy. Journal of Sports Sciences and Medicine, 2011; 10:238-253. Kaux et al. Effects of platelet-rich plasma (PRP) on the healing of Achilles tendons of rats. Wound Repair and Regeneration, 2012 ; 5: 748-756. Smets et al. Applications cliniques du plasma riche en plaquettes (PRP) dans les lésions tendineuses : revue de la littérature. Science & Sport, 2012; 27:141-153 Kaux et al. Eccentric training improves tendon biomechanical properties: a rat model. Journal of Orthopaedic Research, 2012; DOI: 10.1002/jor.22202 Kaux et al. Etude comparative de cinq techniques de préparation plaquettaire (platelet-rich plasma). Pathologie-Biologie, 2011; 59: 157-160. Plus de références sur orbi.ulg.ac.be [less ▲]

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See detailRADIATION SHIELDING OF COMPOSITE SPACE ENCLOSURES
Atxaga, G.; Marcos, J.; Jurado, M. et al

Conference (2012, October)

Space electronic systems employ enclosures to shield sensitive components from space radiation. The purpose of shielding is to attenuate the energy and the flux of ionizing radiation as they pass through ... [more ▼]

Space electronic systems employ enclosures to shield sensitive components from space radiation. The purpose of shielding is to attenuate the energy and the flux of ionizing radiation as they pass through the shield material, such that the energy per unit mass (or dose) absorbed in silicon is sufficiently below the maximum dose ratings of electronic components. The received radiation amount varies significantly depending on several variables that include mission parameters (orbit, altitude, inclination and duration), spacecraft design (spacecraft wall thickness and panel-enclosure location). To achieve the optimum shielding with the minimum weight, all these variables have to be considered in the design. Energetic particles, mainly electrons and protons, can destroy or cause malfunctions in spacecraft electronics. The standard practice in space hardware is the use of aluminium as both a radiation shield and structural enclosure. Composite structures show potential for significant mass savings. However, conventional graphite epoxy composites are not as efficient shielding materials as aluminium because of their lower density, that is, for the same mass, composites provide 30 to 40% less radiation attenuation than aluminium. A solution is to embed high density (atomic weight) material into the laminate. This material, typically metallic material, can be dispersed in the composite or used as layers in the laminate (foils). The main objective of the “Radiation Shielding of Composite Space Enclosures” (SIDER) project is the development of the technologies and tools required to obtain lightweight, safe, robust and reliable composite structures. Two different strategies are being analysed as alternatives for radiation shielding: and he incorporation of a high density material foil. This paper will present and analyse the radiation shielding obtained by the incorporation of nanomaterials in composite structures. [less ▲]

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See detailEncoded haplotype data as input to ipPCA can better resolve population clustering
Chaichoompu, Kridsadakorn ULg; Pongsakorn, Wangkumhang; Anunchai, Assawamakin et al

Poster (2012, October)

Background Studies in population genetics are mainly based on the analysis of genetic variations among different populations. With the advent of advanced genotyping technology, large number of Single ... [more ▼]

Background Studies in population genetics are mainly based on the analysis of genetic variations among different populations. With the advent of advanced genotyping technology, large number of Single Nucleotide Polymorphisms (SNPs) can be used to capture the underlying population variations. Iterative pruning principal component analysis (ipPCA) is a very powerful tool to cluster subpopulations based on their SNP profiles. However, when several similar populations are considered in the analysis, differentiating these populations can become very challenging. Haplotype has been known to capture more segregation information and higher power than SNP but due to high inference complexity, this concept has not been widely used. Recently, haplotype sharing (HS) was reported as a good alternative method to evaluate variation among populations. HS interrogates the entire genotyping without estimating haplotype block, making it computational efficient, yet retaining population profile. Adopting HS technique and introducing a new haplotype encoding as the input to ipPCA to perform population clustering can yield very good outcomes. Results In this study we transformed an indigenous Thai SNP genotyping data, obtained from Pan Asian SNP consortium, into encoded haplotype profiles. The dataset include 13 indigenous populations (245 individuals) composing of approximately 54K SNPs for each individual. To do this, an encoded haplotype matrix was constructed by inferring overlapping haplotype based on sliding window approach in BEAGLE, an efficient haplotype inference tool. We fed this encoded haplotype matrix to ipPCA to cluster these individuals into sub-groups using only their genetic profiles. We compared the results obtained from standard protocol of ipPCA with the one that use the encoded haplotype matrix in terms of numbers of clustered subpopulations as well as the accuracy to correctly assign an individual to a correct subpopulation. Using the encoded haplotype matrix as input to ipPCA rendered the exact 13 subpopulations to be clustered with 99.18% of individual assignment accuracy, whereas the conventional ipPCA identified only 10 subpopulations with 93.47% of individual assignment accuracy. Conclusions Our result demonstrated the great potential of using the encoded haplotype matrix with ipPCA for population genetics studies. This new protocol can promote the clustering of individuals using only their genetic profiles. [less ▲]

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See detailL’État et la gestion de la grippe A(H1N1)
Rossignol, Nicolas ULg; Thoreau, François ULg

in Revue Nouvelle (2012), 10

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See detailSynthèse de MWNT dans un réacteur continu incliné rotatif à lit mobile par procédé CCVD
Douven, Sigrid ULg; Pirard, Sophie ULg; Chan, Fang-Yue et al

Conference (2012, October)

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See detailActive Foxp3 (+) Regulatory T Cells Rather Than Other Foxp3 (+) T Cells Subsets CorrelateWith Clinical Response To Infliximab Therapy For IBD
Li, Z; Vermeire, S; Bullens, D et al

Poster (2012, October)

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See detailThe Continuum of Grief: From Scandinavian Mythology to Zen Buddhism: JanetFrame’s Intertextual Strategies in Snowman, Snowman
Gabrielle, Cindy ULg

in Sino-USEnglish Teaching (2012), 9(10), 1627-1636

In the wake of Richards Benton’s “Keats and Zen” (published in Philosophy East and West (1966)), this paper sets out to examine Janet Frame’s appropriation of Buddhist philosophy in Snowman, Snowman (1962 ... [more ▼]

In the wake of Richards Benton’s “Keats and Zen” (published in Philosophy East and West (1966)), this paper sets out to examine Janet Frame’s appropriation of Buddhist philosophy in Snowman, Snowman (1962). The novella’s allusions to a Buddhist-like epistemology, together with its subtle references to Scandinavian myths, however, have so far remained uncovered and are therefore best approached in the light of what has been called “the suppressed intertextuality in post-colonial writing”. The author’s intention in this paper is twofold: On the one hand, the author will suggest that post-colonial writers do not necessarily write against the Western canon and that maintaining the contrary amounts to vindicating the centrality of imperial texts in the contemporary literary scene—an endeavour which is hardly post-colonial. On the other hand, the author will go some way towards shifting eastward the core of Frame’s ontology by suggesting that her poetics is anchored not only in Western thinking, but also, perhaps more importantly so, in Eastern philosophy. The author’s primary impulse, however, in examining the interplay between canonical and peripheral intertextualities, is to illuminate in fundamental fashion the haunting beauty of the writer’s universe and the lyricism of Snowman, Snowman. [less ▲]

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See detailThe Pair Beam Production Spectrum from Photon-Photon Annihilation in Cosmic Voids
Schlickeiser, Reinhard; Elyiv, Andrii ULg; Ibscher, D et al

in Astrophysical Journal (2012), 758(2), 18

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See detailCollaborative care in the addiction management of alcohol, illicit drugs and hypnotics and tranquilizers in the Belgian working population
Van Royen, Kathleen; Remmen, Roy; Vanmeerbeek, Marc ULg et al

Poster (2012, October)

Background: General practitioners (GPs) and occupational physicians (OPs) play an important role in detecting and managing substance abuse in the working population. Their collaboration is critical in ... [more ▼]

Background: General practitioners (GPs) and occupational physicians (OPs) play an important role in detecting and managing substance abuse in the working population. Their collaboration is critical in coordinating care, facilitate a quicker rehabilitation and shorten sickleave. A systematic literature search was performed according to the ADAPTE-framework to explore if guidelines exist for collaboration between GPs and OPs in substance abuse management. Method: International guidelines regarding collaborative care for alcohol abuse, illicit drug use and hypnotics and tranquilizers were identified by a detailed systematic search in the Guidelines International Network (GIN) and US National Guidelines Clearinghouse (NGC) databases. Results: In total 20 guidelines were considered of sufficient methodological quality, based on criteria of the Appraisal of Guidelines for Research and Education (AGREE) II instrument. Two out of 20 eligible guidelines reported on the role of OPs. There is a lack of adequate evidence on the role of the OP in substance abuse management. No practical avenues for collaboration between GPs and OPs in the management of substance abuse were suggested. Conclusions: In order to ensure adequate substance abuse management, collaborative models for general practice and occupational health should be developed. We recommend to study pros and cons for collaboration as well as the best way to achieve it. [less ▲]

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