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See detailAteliers "L'activité un prisme multifacettes": L'institution, fin de la vie active ?
Adam, Stéphane ULg

Conference (2012, December 11)

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See detailQuestions à Dominique Pradelle ("Par-delà la révolution copernicienne")
Dewalque, Arnaud ULg

Diverse speeche and writing (2012)

Discussion of D. Pradelle, "Par-delà la révolution copernicienne. Sujet transcendantal et facultés chez Kant et Husserl" (Paris, PUF, 2012).

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See detailEn attendant la fin des temps: deux espèces d'apocalypticiens
Claisse, Frédéric ULg

Article for general public (2012)

A l'approche de la date fatidique du 21 décembre 2012, l'article revient sur la posture "catastrophiste" en insistant sur le rôle de la fiction et de l'imagination dans nos stratégies collectives d ... [more ▼]

A l'approche de la date fatidique du 21 décembre 2012, l'article revient sur la posture "catastrophiste" en insistant sur le rôle de la fiction et de l'imagination dans nos stratégies collectives d'évitement du pire. Assimilés à tort aux prophètes de malheur, les auteurs de dystopie comme Orwell ou Huxley ne nous décrivent l'avènement d'une menace que pour mieux la conjurer. Sans cette espèce d' "apocalypticiens prophylactiques", comme se décrivait Günther Anders, il est probable que notre capacité à penser la catastrophe serait sérieusement atrophiée. [less ▲]

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See detailRole of HDAC5 depletion induced autophagy on cancer cell death
Hendrick, Elodie ULg; Peixoto, Paul ULg; Mathéus, Nicolas et al

Poster (2012, December 10)

Introduction: Histone deacetylases (HDAC) is a family of eighteen enzymes which modulates the acetylation level of histones and non-histone proteins to regulate gene expression and chromatin structure ... [more ▼]

Introduction: Histone deacetylases (HDAC) is a family of eighteen enzymes which modulates the acetylation level of histones and non-histone proteins to regulate gene expression and chromatin structure. Broad spectrum inhibitors of these enzymes can inhibit tumor growth both in vitro and in vivo and are currently used in clinic as anti-cancer agents. For many years, we are investigating the specific role of individual HDAC members in cancer biology and we have recently demonstrated that depletion of HDAC5 using siRNA technology triggered cancer cells to both autophagy and apoptosis. The study of autophagy in cancer is a new research field that has recently generated tremendous attention due to the recognition that autophagy can have either pro-survival or pro-death functions depending on its level of activation. In addition, more and more studies indicate that a complex relationship exists between autophagy and apoptosis, and that the interplay between these two processes determines whether a cell will live or die. - Aims: The aim of this study is to further understand the role of autophagy induced by HDAC5 depletion. Current investigations include determining the molecular mechanisms of HDAC5 depletion-mediated autophagy and exploring regulatory relationships between autophagy and apoptosis on cancer cell death in absence of HDAC5. - Methods and results : The set up of the autophagy in absence of HDAC5 occurs trough a non-canonical pathway which depends on the JNK activation. This activation could be induced by an inappropriate ROS production. Indeed, a transcriptomic analysis performed in HDAC5 depleted Hela cells highlighted a deregulation of a set of genes implicated in ROS detoxification. This deregulation has been validated by FACS analysis. - Conclusion: Through this study we determined the molecular mechanism implicated in the autophagy induction after HDAC5 silencing. This phenomenon appears dependent of an accumulation of ROS into the cells that activates JNK and mediate cell death by autophagy and apoptosis. Now, in we hope to determine whether manipulation of autophagy may provide a useful way to increase the efficacy of treatments with HDAC inhibitors, and limit tumor progression. [less ▲]

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See detailOncogenic human papillomavirus could directly interact with Natural Killer cells
Renoux, Virginie; Bastin, Renaud ULg; Boniver, Jacques ULg et al

Poster (2012, December 10)

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See detailCharacterization of chemotherapy-induced cell death in glioblastoma
Coupienne, Isabelle ULg; Fettweis, Grégory ULg; Piette, Jacques ULg

Poster (2012, December 10)

Glioblastoma constitute the most frequent and deadliest type of brain tumors. Their annual incidence is estimated between 5 and 8 cases per 100,000 people in Europe and North America. They are resistant ... [more ▼]

Glioblastoma constitute the most frequent and deadliest type of brain tumors. Their annual incidence is estimated between 5 and 8 cases per 100,000 people in Europe and North America. They are resistant to all current therapies and are associated with a very high rate of recurrence. The associated prognosis is generally very poor and most patients die within a year after diagnosis. Unfortunately, despite extensive research and use of multimodality treatments combining surgical resection, chemotherapy and radiotherapy, survival hasn’t really much improved over the last 20 years. Indeed, these tumors were shown to be characterized by a high radio- and chemo-resistance. Glioblastoma cells exhibit overexpression of the anti-apoptotic Bcl-2 family proteins and downregulation of its pro-apoptotic members, high expression of the IAPs (Inhibitors of Apoptosis Proteins) and constitutive activation of the pro-survival NF-κB pathway. Currently, the most commonly used treatment offering the best prognosis to patients consists in a combination of maximal surgical tumor resection (when feasible) with subsequent radio- and/or chemotherapy. Among the most commonly used chemotherapeutic agents, the alkylating agent temozolomide and the topoisomerase I inhibitor camptothecin occupy a central position. Therefore, in this study, the impact of both temozolomide and irinotecan (a soluble derivative of camptothecin) on glioma cell survival will be investigated. Important progress was made in the comprehension of the molecular mechanisms underlying tumor development and progression however, survival benefits conferred by the use of new drugs and therapeutic strategies are counted in months rather than years. Consequently, there is an urge to rapidly improve the efficiency of the currently used treatments. This research project consists in (i) the study of the mechanisms implicated in glioblastoma cell death induced by two chemotherapeutic agents : temozolomide and irinotecan, (ii) the identification of the mechanisms underlying the resistance of glioblastoma to these treatments, (iii) the use of pharmacological tools to interfere with those resistance strategies to enhance chemotherapy efficiency. Necrosis was, until recently, long thought to be only accidental. However, it was shown to be finely regulated by specific signalling pathways. Programmed necrosis often takes place in cells in which apoptosis cannot be properly activated and serves as a back-up cell death pathway. Previous work from our lab having already demonstrated that glioblastoma are, at least partially, apoptosis-defective, special emphasis is put on the study of necrotic parameters. Results from survival tests performed on several glioblastoma cell lines in the presence of necrotic inhibitors like necrostatin-1 (an inhibitor of the central regulator of the necrotic pathway RIP1) allows to partially overcome temozolomide and irinotecan-induced glioblastoma cell death, highlighting the role played by programmed necrosis in chemotherapy sensitivity. [less ▲]

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See detailOnline monitoring of the interaction of balls and slurry with the Sensomag ®
Köttgen, Axel; Leroy, Sophie ULg; Bastin, David ULg et al

Poster (2012, December 10)

Presentation of Optimag Project results. Optimag aims to optimize the ball milling operations through the use of an embarked sensor, called the Sensomag, and developed by Magotteaux to monitor in real ... [more ▼]

Presentation of Optimag Project results. Optimag aims to optimize the ball milling operations through the use of an embarked sensor, called the Sensomag, and developed by Magotteaux to monitor in real time the position of the slurry and the grinding balls. [less ▲]

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See detailPolarization Holography with liquid crystals polymers and applications
Piron, Pierre ULg; Blain, Pascal ULg; Habraken, Serge ULg et al

Conference (2012, December 10)

Liquid Crystals Polymers are birefringent molecules locally orientable. By recording the polarization pattern due to the overlap of differently polarized beams on LCP, space-variant retarders are realized ... [more ▼]

Liquid Crystals Polymers are birefringent molecules locally orientable. By recording the polarization pattern due to the overlap of differently polarized beams on LCP, space-variant retarders are realized. We present two applications polarization holography and coronagraphy [less ▲]

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See detailRole of γδ T cells in HPV-induced cancer progression
Van hede, Dorien ULg; Bastin, Renaud; Francis, Floriane et al

Poster (2012, December 10)

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See detailSéminaire des chercheurs Télévie 2013
Cimino, Jonathan ULg; Sounni, Nor Eddine ULg; Calligaris, David ULg et al

Poster (2012, December 10)

Séminaire des chercheurs Télévie 2013

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See detailBatch Mode Reinforcement Learning based on the Synthesis of Artificial Trajectories
Fonteneau, Raphaël ULg

Speech/Talk (2012)

Batch mode reinforcement learning (BMRL) is a field of research which focuses on the inference of high-performance control policies when the only information on the control problem is gathered in a set of ... [more ▼]

Batch mode reinforcement learning (BMRL) is a field of research which focuses on the inference of high-performance control policies when the only information on the control problem is gathered in a set of trajectories. Such situations occur for instance in the case of clinical trials, for which data are collected in the form of batch time series of clinical indicators. When the (state, decision) spaces are large or continuous, most of the techniques proposed in the literature for solving BMRL problems combine value or policy iteration schemes from the Dynamic Programming (DP) theory with function approximators representing (state-action) value functions. While successful in many studies, the use of function approximators for solving BMRL problems has also drawbacks. In particular, the use of function approximator makes performance guarantees difficult to obtain, and does not systematically take advantage of optimal trajectories. In this talk, I will present a new line of research for solving BMRL problems based on the synthesis of ``artificial trajectories'' which opens avenues for designing new BMRL algorithms. In particular, it avoids the two above-mentioned drawbacks of the use of function approximator. [less ▲]

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See detailRegulation of breast cancer cell properties by MT4-MMP
Yip, Cassandre ULg; PAYE, Alexandra ULg; Truong, Alice ULg et al

Scientific conference (2012, December 10)

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See detailMise en perspective de l'état de vulnérabilité alimentaire au Niger
Andres, Ludovic ULg

Scientific conference (2012, December 10)

Cette présentation lors d'un séminaire tente de faire l'état des lieux de la sécurité alimentaire au Niger. Elle aborde la sécurité alimentaire à travers deux indices composites fortement axés sur la ... [more ▼]

Cette présentation lors d'un séminaire tente de faire l'état des lieux de la sécurité alimentaire au Niger. Elle aborde la sécurité alimentaire à travers deux indices composites fortement axés sur la disponibilité et l'accessibilité alimentaire. Elle identifie leurs limites et avantages ainsi que leurs potentiels face à de futures recherches. [less ▲]

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See detailEffects of tributyltin (TBT) and triphenyltin (TPT) on the reproduction of the freshwater snail Lymnaea stagnalis
Lagadic, Laurent; Giusti, Arnaud ULg; Barsi, Alpar et al

Conference (2012, December 10)

Detailed reference viewed: 38 (11 ULg)