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See detailRisk Of Malignancies In A Single Center Cohort Of IBD-Patients Treated with Immunosuppressives and Anti-TNF-antibodies
Steinborn, A; Beigel, F; Breiteneicher, S et al

in Journal of Crohn’s and Colitis (2011)

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See detailAtouts, faiblesses et défis futurs de la filière lait et produits laitiers en Belgique
Burny, Philippe ULg

in Centre wallon de Recherches agronomiques (Ed.) Seizième Carrefour des Productions Animales "La Filière laitière bovine européenne est-elle durable ?" (2011)

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See detailComparison of output-only methods for condition monitoring of industrials systems
Rutten, Christophe ULg; Nguyen, Viet Ha; Golinval, Jean-Claude ULg

in Journal of Physics: Conference Series (2011), 305

In the field of structural health monitoring or machine condition monitoring, the activation of nonlinear dynamic behavior complicates the procedure of damage or fault detection. Blind source separation ... [more ▼]

In the field of structural health monitoring or machine condition monitoring, the activation of nonlinear dynamic behavior complicates the procedure of damage or fault detection. Blind source separation (BSS) techniques are known as efficient methods for damage diagnosis. However, most of BSS techniques repose on the assumption of the linearity of the system and the need of many sensors. This article presents some possible extensions of those techniques that may improve the damage detection, e.g. Enhanced-Principal Component Analysis (EPCA), Kernel PCA (KPCA) and Blind Modal Identification (BMID). The advantages of EPCA rely on its rapidity of use and its reliability. The KPCA method, through the use of nonlinear kernel functions, allows to introduce nonlinear dependences between variables. BMID is adequate to identify and to detect damage for generally damped systems. In this paper, damage is firstly examined by Stochastic Subspace Identification (SSI); then the detection is achieved by comparing subspace features between the reference and a current state through statistics and the concept of subspace angle. Industrial data are used as illustration of the methods. [less ▲]

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See detailThe prosody of non-native speech
Rasier, Laurent ULg

Scientific conference (2011)

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See detailEfficacy of FDG PET/CT for diagnosing synchronous tumors and metastases in head and neck tumors : Initial results and evaluation.
MINON, AL.; DEMEZ, Pierre ULg; MOREAU, Pierre ULg et al

in Journal of Nuclear Medicine (The) (2011), 52(SUPPL), 1863

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See detailCompte-rendu de l'ouvrage de E. Saccone: Ritorni: la seconda lettura
de Seta, Ilaria ULg

in Oblio – Osservatorio Bibliografico della Letteratura Italiana Otto-novecentesca (2011), I(2-3),

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See detailQ Fever: Current State of Knowledge and Perspectives of Research of a Neglected Zoonosis
Porter, Sarah ULg; Czaplicki, G.; Mainil, Jacques ULg et al

in International Journal of Microbiology (2011)

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See detailExternal Evaluation Report Über Die Common Security and Defence Policy Modules
Paile, Sylvain ULg

Book published by Ministry of Defence and Sports of the Federal Republic of Austria (2011)

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See detailSeeing the self disappear from the brain.
Guldenmund, Justus Pieter ULg

Speech (2011)

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See detailMucosal gene expression of cell adhesion molecules, chemokines, and chemokine receptors in patients with inflammatory bowel disease before and after infliximab treatment.
Arijs, Ingrid; De Hertogh, Gert; Machiels, Kathleen et al

in Acta Gastro-Enterologica Belgica (2011), 106(4), 748-61

OBJECTIVES: Inflammatory bowel disease (IBD) is characterized by a continuous influx of leukocytes into the gut wall. This migration is regulated by cell adhesion molecules (CAMs), and selective ... [more ▼]

OBJECTIVES: Inflammatory bowel disease (IBD) is characterized by a continuous influx of leukocytes into the gut wall. This migration is regulated by cell adhesion molecules (CAMs), and selective antimigration therapies have been developed. This study investigated the effect of infliximab therapy on the mucosal gene expression of CAMs in IBD. METHODS: Mucosal gene expression of 69 leukocyte/endothelial CAMs and E-cadherin was investigated in 61 IBD patients before and after first infliximab infusion and in 12 normal controls, using Affymetrix gene expression microarrays. Quantitative reverse transcriptase-PCR (qRT-PCR), immunohistochemistry, and western blotting were used to confirm the microarray data. RESULTS: When compared with control colons, the colonic mucosal gene expression of most leukocyte/endothelial adhesion molecules was upregulated and E-cadherin gene expression was downregulated in active colonic IBD (IBDc) before therapy, with no significant colonic gene expression differences between ulcerative colitis and colonic Crohn's disease. Infliximab therapy restored the upregulations of leukocyte CAMs in IBDc responders to infliximab that paralleled the disappearance of the inflammatory cells from the colonic lamina propria. Also, the colonic gene expression of endothelial CAMs and of most chemokines/chemokine receptors returned to normal after therapy in IBDc responders, and only CCL20 and CXCL1-2 expression remained increased after therapy in IBDc responders vs. control colons. When compared with control ileums, the ileal gene expression of MADCAM1, THY1, PECAM1, CCL28, CXCL1, -2, -5, -6, and -11, and IL8 was increased and CD58 expression was decreased in active ileal Crohn's disease (CDi) before therapy, and none of the genes remained dysregulated after therapy in CDi responders vs. control ileums. This microarray study identified a number of interesting targets for antiadhesion therapy including PECAM1, IL8, and CCL20, besides the currently studied alpha4beta7 integrin-MADCAM1 axis. CONCLUSIONS: Our data demonstrate that many leukocyte/endothelial CAMs and chemokines/chemokine receptors are upregulated in inflamed IBD mucosa. Controlling the inflammation with infliximab restores most of these dysregulations in IBD. These results show that at least part of the mechanism of anti-tumor necrosis factor-alpha therapy goes through downregulation of certain adhesion molecules. [less ▲]

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See detailSynthesis and organocatalytic applications of imidazol(in)ium-2- thiocarboxylates
Hans, Morgan ULg; Wouters, Johan; Demonceau, Albert ULg et al

in European Journal of Organic Chemistry (2011), (35), 7083-7091

Five imidazol(in)ium-2-thiocarboxylates bearing cyclohexyl, mesityl, or 2,6-diisopropylphenyl substituents on their nitrogen atoms were prepared from the corresponding imidazol(in)ium chlorides or ... [more ▼]

Five imidazol(in)ium-2-thiocarboxylates bearing cyclohexyl, mesityl, or 2,6-diisopropylphenyl substituents on their nitrogen atoms were prepared from the corresponding imidazol(in)ium chlorides or tetrafluoroborates in a one-pot, two-step procedure involving the in situ generation of free N-heterocyclic carbenes (NHCs) with a strong base followed by trapping with carbonyl sulfide. The resulting NHC•COS zwitterions were isolated in high yields and characterized by IR and NMR spectroscopy. The molecular structure of SIMes•COS was determined by X-ray diffraction analysis. Experimental data and DFT calculations indicated that the negative charge on the thiocarboxylate anion is preferentially delocalized on the sulfur atom. Thermogravimetric analysis showed that the NHC•COS zwitterions undergo thermolysis at temperatures ranging between 110 and 180 °C in the solid state. They are also rather labile in solution. Unlike the related NHC•CS2 betaines, which are highly stable, crystalline materials, they displayed the same type of behavior as the analogous carboxylate adducts, which readily lose their CO2 moiety upon heating or dissolution. Thus, imidazol(in)ium-2-thiocarboxylates acted as convenient NHC precursors in two model organocatalytic transformations. Of the five thiocarboxylates examined, ICy•COS was the most efficient at promoting the acylation of benzyl alcohol with vinyl acetate, whereas SIMes•COS afforded the highest activity in benzoin condensation. [less ▲]

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See detailState of the Art of Existing Early Design Simulation Tools for Net Zero Energy Buildings: A Comparison of Ten Tools
Attia, Shady ULg

Report (2011)

Given the challenges to design Net Zero Energy Buildings (NZEBs) the use of Building Performance Simulation (BPS) tools during early design phases has been indispensable. In this context, BPS techniques ... [more ▼]

Given the challenges to design Net Zero Energy Buildings (NZEBs) the use of Building Performance Simulation (BPS) tools during early design phases has been indispensable. In this context, BPS techniques can be supportive when integrated early in the design process. However, architects suffer from BPS tools limitations during this decisive phase that addresses more the building geometry and envelope. To identify those limitations and as part of the International Energy Agency (IEA) Task 40: Towards Net Zero Energy Buildings, this report compares ten early design BPS tools. The aim is to define the potential of using and integrating the tools by architect during the design of NZEBs. The examined tools include HEED, e-Quest, ENERGY-10, Vasari, Solar Shoebox, Open Studio Plug-in, IES-VE- Ware, DesignBuilder, ECOTECT and BEopt. The comparison is based on five criteria including usability, optimization, interoperability, accuracy and design process integration of the tools. The results describe tools limitations and major requirements to meet the NZEBs objective implications. [less ▲]

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See detailEntre parc et muséum: unité et diversité des musées de science et technique
Gob, André ULg

in Chaumier, Serge (Ed.) Expoland : Ce que le parc fait au musée : ambivalence des formes de l'exposition (2011)

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See detailEnd of life care in the operating room for non-heart-beating donors: organization at the University Hospital of Liege.
JORIS, Jean ULg; KABA, Abdourahmane ULg; LAUWICK, Séverine ULg et al

in Transplantation Proceedings (2011), 43(9), 3441-4

Non-heart-beating (NHB) organ donation has become an alternative source to increase organ supply for transplantation. A NHB donation program was implemented in our institution in 2002. As in many ... [more ▼]

Non-heart-beating (NHB) organ donation has become an alternative source to increase organ supply for transplantation. A NHB donation program was implemented in our institution in 2002. As in many institutions the end of life care of the NHB donor (NHBD) is terminated in the operating room (OR) to reduce warm ischemia time. Herein we have described the organization of end of life care for these patients in our institution, including the problems addressed, the solution proposed, and the remaining issues. Emphasis is given to our protocol elaborated with the different contributors of the chain of the NHB donation program. This protocol specifies the information mandatory in the medical records, the end of life care procedure, the determination of death, and the issue of organ preservation measures before NHBD death. The persisting malaise associated with NHB donation reported by OR nurses is finally documented using an anonymous questionnaire. [less ▲]

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See detailFormer des établissements de la petite enfance à l'approche interactive
Stambak, Mira; Pirard, Florence ULg; Amilhaud, Geneviève et al

in Hardy, Marianne; Belmont, Brigitte; Noël-Hureau, Elisabeth (Eds.) Des recherches-actions pour changer l'école. (2011)

The interactive pedagogy elaborated by the Cresas (in Paris) has influenced the educational practice and the professional accompaniment in the early childhood sector. It can be interpreted as a ... [more ▼]

The interactive pedagogy elaborated by the Cresas (in Paris) has influenced the educational practice and the professional accompaniment in the early childhood sector. It can be interpreted as a professionalization process where actions, actors, and environment undergo change simultaneously. [less ▲]

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See detailFinal results of a phase IIa, randomised, open-label trial to evaluate the percutaneous intramyocardial transplantation of autologous skeletal myoblasts in congestive heart failure patients: the SEISMIC trial.
Duckers, Henricus J.; Houtgraaf, Jaco; Hehrlein, Christoph et al

in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology (2011), 6(7), 805-12

AIMS: The SEISMIC study was an open-label, prospective, randomised study to assess the safety and feasibility of percutaneous myoblast implantation in heart failure patients with implanted cardioverter ... [more ▼]

AIMS: The SEISMIC study was an open-label, prospective, randomised study to assess the safety and feasibility of percutaneous myoblast implantation in heart failure patients with implanted cardioverter-defibrillators (ICD). METHODS AND RESULTS: Patients were randomised 2:1 to autologous skeletal myoblast therapy vs. optimal medical treatment. The primary safety end-point was defined as the incidence of procedural and device related serious adverse events, whereas the efficacy endpoints were defined as the change in global LVEF by MUGA scan, change in NYHA classification of heart failure and in the distance achieved during a six-minute walk test (6MW) at 6-month follow-up. Forty subjects were randomised to the treatment arm (n=26), or to the control arm (n=14). There were 12 sustained arrhythmic events and one death after episodes of ventricular tachycardia (VT) in the treatment group and 14 events in the control group (P=ns). At 6-month follow-up, 6MW distance improved by 60.3+/-54.1?meters in the treated group as compared to no improvement in the control group (0.4+/-185.7?meters; P=ns). In the control group, 28.6% experienced worsening of heart failure status (4/14), while 14.3% experienced an improvement in NYHA classification (2/14). In the myoblast-treatment arm, one patient experienced a deterioration in NYHA classification (8.0%), whereas five patients improved one or two classes (20.0%; P=0.06). However, therapy did not improve global LVEF measured by MUGA at 6-month follow-up. CONCLUSIONS: These data indicate that implantation of myoblasts in patients with HF is feasible, appears to be safe and may provide symptomatic relief, though no significant effect was detected on global LVEF. [less ▲]

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See detailStudy of six models of the instantaneous pressure-volume relationship
Lucas, Alexandra ULg; Dauby, Pierre ULg; Desaive, Thomas ULg et al

in Proceedings of the XXIIIth Congress of the ISB (2011)

Models and simulations are very useful to study interactions between anatomic structures and physical cardiac phenomena. In this work, we are interested in models of the instantaneous pressure-volume ... [more ▼]

Models and simulations are very useful to study interactions between anatomic structures and physical cardiac phenomena. In this work, we are interested in models of the instantaneous pressure-volume relationship, i.e. isochrone models. More precisely, we concentrate on the 6 models considered by Lankhaar et al. [1]. We propose a critical analysis of the work of these authors and suggest some improvement of their procedure. [1] Lankhaar J.-W. et al. Modeling the Instantaneous Pressure–Volume Relation of the Left Ventricle: A Comparison of Six Models. Annals of Biomedical Engineering, Volume 37, Number 9, 1710-1726, 2009. [less ▲]

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See detailAcetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase.
Guarani, Virginia; Deflorian, Gianluca; Franco, Claudio A et al

in Nature (2011), 473(7346), 234-8

Notch signalling is a key intercellular communication mechanism that is essential for cell specification and tissue patterning, and which coordinates critical steps of blood vessel growth. Although subtle ... [more ▼]

Notch signalling is a key intercellular communication mechanism that is essential for cell specification and tissue patterning, and which coordinates critical steps of blood vessel growth. Although subtle alterations in Notch activity suffice to elicit profound differences in endothelial behaviour and blood vessel formation, little is known about the regulation and adaptation of endothelial Notch responses. Here we report that the NAD(+)-dependent deacetylase SIRT1 acts as an intrinsic negative modulator of Notch signalling in endothelial cells. We show that acetylation of the Notch1 intracellular domain (NICD) on conserved lysines controls the amplitude and duration of Notch responses by altering NICD protein turnover. SIRT1 associates with NICD and functions as a NICD deacetylase, which opposes the acetylation-induced NICD stabilization. Consequently, endothelial cells lacking SIRT1 activity are sensitized to Notch signalling, resulting in impaired growth, sprout elongation and enhanced Notch target gene expression in response to DLL4 stimulation, thereby promoting a non-sprouting, stalk-cell-like phenotype. In vivo, inactivation of Sirt1 in zebrafish and mice causes reduced vascular branching and density as a consequence of enhanced Notch signalling. Our findings identify reversible acetylation of the NICD as a molecular mechanism to adapt the dynamics of Notch signalling, and indicate that SIRT1 acts as rheostat to fine-tune endothelial Notch responses. [less ▲]

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