References of "2011"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailHTLV-1 propels thymic human T cell development in "human immune system" Rag2(-)/(-) gamma c(-)/(-) mice.
Villaudy, Julien; Wencker, Melanie; Gadot, Nicolas et al

in PLoS Pathogens (2011), 7(9), 1002231

Alteration of early haematopoietic development is thought to be responsible for the onset of immature leukemias and lymphomas. We have previously demonstrated that Tax(HTLV-1) interferes with ss-selection ... [more ▼]

Alteration of early haematopoietic development is thought to be responsible for the onset of immature leukemias and lymphomas. We have previously demonstrated that Tax(HTLV-1) interferes with ss-selection, an important checkpoint of early thymopoiesis, indicating that human T-cell leukemia virus type 1 (HTLV-1) infection has the potential to perturb thymic human alphabeta T-cell development. To verify that inference and to clarify the impact of HTLV-1 infection on human T-cell development, we investigated the in vivo effects of HTLV-1 infection in a "Human Immune System" (HIS) Rag2(-)/(-)gamma(c)(-)/(-) mouse model. These mice were infected with HTLV-1, at a time when the three main subpopulations of human thymocytes have been detected. In all but two inoculated mice, the HTLV-1 provirus was found integrated in thymocytes; the proviral load increased with the length of the infection period. In the HTLV-1-infected mice we observed alterations in human T-cell development, the extent of which correlated with the proviral load. Thus, in the thymus of HTLV-1-infected HIS Rag2(-)/(-)gammac(-)/(-) mice, mature single-positive (SP) CD4(+) and CD8(+) cells were most numerous, at the expense of immature and double-positive (DP) thymocytes. These SP cells also accumulated in the spleen. Human lymphocytes from thymus and spleen were activated, as shown by the expression of CD25: this activation was correlated with the presence of tax mRNA and with increased expression of NF-kB dependent genes such as bfl-1, an anti-apoptotic gene, in thymocytes. Finally, hepato-splenomegaly, lymphadenopathy and lymphoma/thymoma, in which Tax was detected, were observed in HTLV-1-infected mice, several months after HTLV-1 infection. These results demonstrate the potential of the HIS Rag2(-)/(-)gamma(c)(-)/(-) animal model to elucidate the initial steps of the leukemogenic process induced by HTLV-1. [less ▲]

Detailed reference viewed: 8 (5 ULg)
Full Text
Peer Reviewed
See detailOn the Origin of Model Relations among Transverse-Momentum Dependent Parton Distributions
Lorce, Cédric ULg; Pasquini, B.

in Physical Review. D, Particles, Fields, Gravitation, and Cosmology (2011), D84

Transverse-momentum dependent parton distributions (TMDs) are studied in the framework of quark models. In particular, quark-model relations among TMDs are reviewed, elucidating their physical origin in ... [more ▼]

Transverse-momentum dependent parton distributions (TMDs) are studied in the framework of quark models. In particular, quark-model relations among TMDs are reviewed, elucidating their physical origin in terms of the quark-spin structure in the nucleon. The formal aspects of the derivation of these relations are complemented with explicit examples, emphasizing how and to which extent the conditions which lead to relations among TMDs are implemented in different classes of quark models. [less ▲]

Detailed reference viewed: 12 (4 ULg)
Full Text
See detailNew insights on the role of root radial conductivity on the overall uptake dynamics
Lobet, Guillaume ULg; Javaux, M.; Couvreur, V. et al

Conference (2011)

Detailed reference viewed: 9 (1 ULg)
Full Text
Peer Reviewed
See detailLa mobilité étudiante au prisme du discours spontané: les représentations de la langue française
Meunier, Deborah ULg

in Esteve, I (Ed.) Autour des langues et du langage - perspective pluridisciplinaire (2011)

Detailed reference viewed: 29 (4 ULg)
See detailInventaire des archives du Comité de Secours et d'Alimentation de la Province de Liège (1914-1922)
Delvaux, Anne-Catherine ULg

Book published by Archives générales du Royaume (2011)

Detailed reference viewed: 6 (0 ULg)
Full Text
See detailBioinformatics tools to decrypt pyoverdine biosynthesis in Pseudomonas sp.
Vanvlassenbroeck, Aurélien; Leclère, Valérie; Pupin, Maude et al

Poster (2011)

Detailed reference viewed: 16 (4 ULg)
Full Text
Peer Reviewed
See detailAnalysis of positional candidate genes in the AAA1 susceptibility locus for abdominal aortic aneurysms on chromosome 19.
Lillvis, J. H.; Kyo, Y.; Tromp, G. et al

in BMC Medical Genetics (2011), 12(1), 14

ABSTRACT: BACKGROUND: Abdominal aortic aneurysm (AAA) is a complex disorder with multiple genetic risk factors. Using affected relative pair linkage analysis, we previously identified an AAA ... [more ▼]

ABSTRACT: BACKGROUND: Abdominal aortic aneurysm (AAA) is a complex disorder with multiple genetic risk factors. Using affected relative pair linkage analysis, we previously identified an AAA susceptibility locus on chromosome 19q13. This locus has been designated as the AAA1 susceptibility locus in the Online Mendelian Inheritance in Man (OMIM) database. METHODS: Nine candidate genes were selected from the AAA1 locus based on their function, as well as mRNA expression levels in the aorta. A sample of 394 cases and 419 controls was genotyped for 41 SNPs located in or around the selected nine candidate genes using the Illumina GoldenGate platform. Single marker and haplotype analyses were performed. Three genes (CEBPG, PEPD and CD22) were selected for DNA sequencing based on the association study results, and exonic regions were analyzed. Immunohistochemical staining of aortic tissue sections from AAA and control individuals was carried out for the CD22 and PEPD proteins with specific antibodies. RESULTS: Several SNPs were nominally associated with AAA (p < 0.05). The SNPs with most significant p-values were located near the CCAAT enhancer binding protein (CEBPG), peptidase D (PEPD), and CD22. Haplotype analysis found a nominally associated 5-SNP haplotype in the CEBPG/PEPD locus, as well as a nominally associated 2-SNP haplotype in the CD22 locus. DNA sequencing of the coding regions revealed no variation in CEBPG. Seven sequence variants were identified in PEPD, including three not present in the NCBI SNP (dbSNP) database. Sequencing of all 14 exons of CD22 identified 20 sequence variants, five of which were in the coding region and six were in the 3'-untranslated region. Five variants were not present in dbSNP. Immunohistochemical staining for CD22 revealed protein expression in lymphocytes present in the aneurysmal aortic wall only and no detectable expression in control aorta. PEPD protein was expressed in fibroblasts and myofibroblasts in the media-adventitia border in both aneurysmal and non-aneurysmal tissue samples. CONCLUSIONS: Association testing of the functional positional candidate genes on the AAA1 locus on chromosome 19q13 demonstrated nominal association in three genes. PEPD and CD22 were considered the most promising candidate genes for altering AAA risk, based on gene function, association evidence, gene expression, and protein expression. [less ▲]

Detailed reference viewed: 15 (3 ULg)
Full Text
Peer Reviewed
See detailIMA Commission on New Minerals, Nomenclature and Classification (CNMNC), Newsletter 7
Williams, Pete; Hatert, Frédéric ULg; Pasero, Marco et al

in Mineralogical Magazine (2011), 75(1), 27-31

Detailed reference viewed: 5 (0 ULg)
Full Text
See detailAgathe de Catane (5 février), itinéraire d’un culte : de son martyre à la distribution de ses reliques
George, Philippe ULg

in Sant’Agata, Il reliquiario a busto. Contributi interdisciplinari. (2011)

Detailed reference viewed: 45 (3 ULg)
See detailLes droits constitutionnels du contribuable
Bourgeois, Marc ULg; Traversa, Edoardo

in Les droits constitutionnels en Belgique - Les enseignements jurisprudentiels de la Cour constitutionnelle, du Conseil d'Etat et de la Cour de cassation (2011)

Detailed reference viewed: 22 (1 ULg)
Full Text
See detailCompte rendu : La chaussée romaine de Bavay à Tongres (coord.: Gérard Bavay et Bruno Merckx)
Baiwir, Esther ULg

in Wallonnes : Chronique de la Société de Langue et de Littérature Wallonnes (2011), 2

Detailed reference viewed: 41 (2 ULg)
Full Text
Peer Reviewed
See detailLes déterminants de l'adhésion aux mutuelles de santé en Afrique subsaharienne : un inventaire des travaux empiriques
Defourny, Jacques ULg; Failon, Julie ULg

in Mondes en Développement (2011), 153

En Afrique Subsaharienne, les taux d’adhésion aux mutuelles de santé restent généralement à des niveaux très faibles. Cet article vise à synthétiser les résultats des enquêtes déjà réalisées pour ... [more ▼]

En Afrique Subsaharienne, les taux d’adhésion aux mutuelles de santé restent généralement à des niveaux très faibles. Cet article vise à synthétiser les résultats des enquêtes déjà réalisées pour identifier les facteurs qui influencent la décision d’adhérer ou non à ces mutuelles. Au-delà des différences méthodologiques entre ces travaux, notre synthèse fait ressortir deux facteurs majeurs qui étaient plutôt attendus (la capacité financière des populations et la qualité des soins) et les resitue dans une perspective plus large. Elle permet également d’identifier quelques autres paramètres qui semblent aussi jouer un rôle significatif même si les convergences entre les enquêtes sont moins nettes. [less ▲]

Detailed reference viewed: 147 (12 ULg)
Full Text
See detailLe secteur privé à la rescousse de la faune sauvage en Afrique de l’Ouest. Evaluation écologique et économique de la Zone de Chasse de Konkombouri au Burkina Faso
Bouché, Philippe ULg; Lungren, Clark; Moumouni, Dermé

in Parcs & Réserves (2011), 66(4), 12-22

Le Burkina Faso, s’est engagé depuis plusieurs années dans le domaine de la conservation de la Nature, mais souffre du manque de moyens nécessaires pour entretenir et développer son potentiel faunique. En ... [more ▼]

Le Burkina Faso, s’est engagé depuis plusieurs années dans le domaine de la conservation de la Nature, mais souffre du manque de moyens nécessaires pour entretenir et développer son potentiel faunique. En 1996, le Burkina Faso s’est engagé dans une réforme inédite dans ce pays visant à ouvrir la gestion de la faune au secteur privé. Cet article présente à travers l’exemple de la Zone de Chasse de Konkombouri comment le concessionnaire a pu, en mettant en œuvre un certain nombre d’aménagements et certaines activités de gestion de terrain, redynamiser la faune qui s’est multipliée par 3 en 12 ans et comment l’activité de grande chasse a pu créer une dynamique économique favorable à l’Etat, aux communautés locales et aux prestataires de services locaux et étrangers. L’analyse économique compare également les résultats économiques de la ZCK à d’autres zones de chasse d’Afrique Centrale et de l’Ouest. [less ▲]

Detailed reference viewed: 164 (21 ULg)
Full Text
Peer Reviewed
See detailLeukemic cell xenograft in zebrafish embryo for investigating drug efficacy.
Pruvot, Benoist ULg; Jacquel, Arnaud; Droin, Nathalie et al

in Haematologica (2011), 96(4), 612-6

Zebrafish were proposed as an alternative to mammalian models to assess the efficacy and toxicity of antileukemic drugs. Due to the limited number of transgenic zebrafish leukemia models, we explored ... [more ▼]

Zebrafish were proposed as an alternative to mammalian models to assess the efficacy and toxicity of antileukemic drugs. Due to the limited number of transgenic zebrafish leukemia models, we explored human leukemic cell xenograft in zebrafish embryos. Human leukemic cell lines and blast cells sorted from patients with acute myelogenous leukemia were injected 48 hours post-fertilization and remained in the circulation of zebrafish embryos for several days without affecting their development. Imatinib and oxaphorines did not demonstrate any toxicity on normal zebrafish embryos and decreased the leukemic burden in animals xenografted with sensitive leukemic cell lines. Two other molecules, all-trans retinoic acid and the translation inhibitor 4EGI-1, demonstrated teratogenic effects at concentrations shown to be efficient in vitro, which precluded investigation of their antileukemic activity in such models. Altogether, xenografted leukemic cells in zebrafish embryos are a pharmacologically relevant model for screening non-teratogenic drugs. [less ▲]

Detailed reference viewed: 32 (4 ULg)
Full Text
Peer Reviewed
See detailAnalyse des pigments des dessins pariétaux de la grotte Chauvet à Vallon-Pont-d'Arc
Laval, Eric; Salomon, Hélène ULg; Vignaud, Colette et al

Conference (2011)

Detailed reference viewed: 49 (3 ULg)
Full Text
Peer Reviewed
See detailLes oligosaccharides pectiques: production et applications possibles
Combo, Agnan Marie Michel ULg; Mario, Aguedo ULg; Paquot, Michel ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2011), 15(1), 153-164

Les oligosaccharides pectiques ou POS sont des fragments de composition complexe issus de la dégradation chimique, physique ou enzymatique de la pectine. Du fait de l’intérêt de leurs propriétés ... [more ▼]

Les oligosaccharides pectiques ou POS sont des fragments de composition complexe issus de la dégradation chimique, physique ou enzymatique de la pectine. Du fait de l’intérêt de leurs propriétés biologiques, les oligosaccharides pectiques font l’objet de nombreuses études et trouvent aujourd’hui des applications dans des domaines aussi différents que la médecine, l’agriculture et l’industrie agro-alimentaire. Cet écrit présente la structure des pectines ainsi que les différents modes de production des POS en insistant particulièrement sur les différentes enzymes microbiennes permettant de les obtenir et sur les applications possibles de ces POS. [less ▲]

Detailed reference viewed: 29 (8 ULg)
Full Text
Peer Reviewed
See detailLanguage Policies in the Roman Republic and Empire
Rochette, Bruno ULg

in Clackson, James (Ed.) Blackwell companion to the History of the Latin language (2011)

Detailed reference viewed: 233 (3 ULg)