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See detail2D-Vertical Model for Free Surface Incompressible Flows: Validation and Applications
Detrembleur, Sylvain; Dewals, Benjamin ULg; Pirotton, Michel ULg

in Proc. 34th IAHR World Congress - Balance and Uncertainty (2011)

Efficient design of hydraulic structures such as weirs and bottom outlets requires a detailed description of the complex turbulent flows occurring on these structures. Compared to laboratory experiments ... [more ▼]

Efficient design of hydraulic structures such as weirs and bottom outlets requires a detailed description of the complex turbulent flows occurring on these structures. Compared to laboratory experiments, numerical modeling offers more flexibility and cost-effectiveness to test different designs. The non-hydrostatic 2D-vertical model presented here solves the RANS equations for incompressible flows in the vertical plane. It is based on the projection method for pressure-velocity coupling, while free surface tracking is conducted by means of the level set technique and Sussman’s velocity extension algorithm. It enables to predict accurately the flow pattern in the vertical plane and deals with multiple interfaces (jets, drops…). The solver has been validated for both steady and unsteady free surface flows, based on theoretical and experimental data. The paper will detail the application of the model to a pressurized flow and to a sloshing tank. [less ▲]

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See detailGenou douloureux de l'enfant sportif
Kaux, Jean-François ULg

Learning material (2011)

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See detailA new benzotriazole-mediated stereoflexible gateway to hetero-2,5-diketopiperazines
Monbaliu, Jean-Christophe ULg; Hansen, Finn; Beagle, Lucas et al

in Chemistry : A European Journal (2011), 18

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See detailA coupled two-scale computational scheme for the failure of periodic quasi-brittle thin planar shells and its application to masonry
Mercatoris, Benoît ULg; Massart, T. J.

in International Journal for Numerical Methods in Engineering (2011), 85(9), 1177-1206

This paper presents a multi-scale framework for the failure of periodic quasi-brittle thin planar shells. The failure behavior of textured or periodic heterogeneous materials is strongly influenced by ... [more ▼]

This paper presents a multi-scale framework for the failure of periodic quasi-brittle thin planar shells. The failure behavior of textured or periodic heterogeneous materials is strongly influenced by their mesostructure. Their periodicity and the quasi-brittle nature of their constituents result in complex behaviors such as damage-induced anisotropy properties with localization of damage, which are difficult to model by means of macroscopic closed-form constitutive laws. A computational homogenization procedure is used for the in-plane and out-of-plane behavior of such planar shells, and is combined with an acoustic tensor-based failure detection adapted to shell kinematics to detect the structural-scale failure. Based on an assumption of single period failure, the localization of damage at the structural scale is represented by means of mesostructurally informed embedded strong discontinuities incorporated in the macroscopic shell description. A new enhanced scale transition is outlined for shell failure, based on an approximate energy consistency argument to objectively upscale the energy dissipation. The corresponding multi-scale framework results are compared with direct fine-scale modeling results used as a reference for the case of masonry, showing good agreement in terms of the load-bearing capacity, of failure mechanisms and of associated energy dissipation. © 2010 John Wiley & Sons, Ltd. [less ▲]

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See detailInventaire des archives de la Société anonyme métallurgique d'Espérance-Longdoz (1806-1971)
Delvaux, Anne-Catherine ULg

Book published by Archives générales du Royaume (2011)

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See detailContinuum-level modelling of cellular adhesion and matrix production in aggregates.
Geris, Liesbet ULg; Ashbourn, Joanna M A; Clarke, Tim

in Computer Methods in Biomechanics & Biomedical Engineering (2011), 14(5), 403-10

Key regulators in tissue-engineering processes such as cell culture and cellular organisation are the cell-cell and cell-matrix interactions. As mathematical models are increasingly applied to investigate ... [more ▼]

Key regulators in tissue-engineering processes such as cell culture and cellular organisation are the cell-cell and cell-matrix interactions. As mathematical models are increasingly applied to investigate biological phenomena in the biomedical field, it is important, for some applications, that these models incorporate an adequate description of cell adhesion. This study describes the development of a continuum model that represents a cell-in-gel culture system used in bone-tissue engineering, namely that of a cell aggregate embedded in a hydrogel. Cell adhesion is modelled through the use of non-local (integral) terms in the partial differential equations. The simulation results demonstrate that the effects of cell-cell and cell-matrix adhesion are particularly important for the survival and growth of the cell population and the production of extracellular matrix by the cells, concurring with experimental observations in the literature. [less ▲]

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See detailTelomere deregulations possess cytogenetic, phenotype, and prognostic specificities in acute leukemias.
CAPRARO, Valérie ULg; Zane, Linda; Poncet, Delphine et al

in Experimental Hematology (2011), 39(2), 195-2022

OBJECTIVE: Telomeres are protected by tightly regulated factors and elongated by telomerase. Short and/or deprotected chromosomes are recombinogenic and thereby cancer prone. MATERIALS AND METHODS ... [more ▼]

OBJECTIVE: Telomeres are protected by tightly regulated factors and elongated by telomerase. Short and/or deprotected chromosomes are recombinogenic and thereby cancer prone. MATERIALS AND METHODS: Together with the quantification of telomerase activity (TA), measuring telomere length (TL) and expression of the genes that govern telomere protection and elongation are useful for assessing telomere homeostasis. RESULTS: By these means we demonstrate that TL, hTERT, and TA are in the order acute myelogenous leukemia (AML) > T-cell acute lymphoblastic leukemia (T-ALL) > B-cell acute lymphoblastic leukemia (B-ALL) > T-ALL > AML, and B-ALL > AML > T-ALL. AML0 and AML3 display the lowest amounts of hTERT transcripts, and ALL and AML cells with cytogenetic abnormalities possess the shortest telomeres. hTERT expression includes phenotype-specific RNA maturation and correlates with TA but not with TL. A wide ratio of TA to hTERT expression between leukemia subtypes suggests phenotype-specific hTERT post-transcriptional deregulations. B- and T-ALL overexpress Ku70 and Pinx1, T-ALL PTOP and RAP1, and B-ALL TRF2, the expression of which is significantly higher in cases with abnormal karyotype. hTERT transcription and TL correlate with response to intensive chemotherapy, and hTERT and RAD50 are independent prognostic factors for survival. CONCLUSIONS: Each leukemia subtype possesses specific telomere dysregulations that rely on phenotype, karyotype, response to treatment, and survival. [less ▲]

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See detailNeuropathie ulnaire au coude : étude combinée des muscles abductor digiti minimi et interosseus I
WANG, François-Charles ULg

in Lettre du Neurologue (La) : le Courrier du Spécialiste (2011)

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See detailLes allégations de santé dans le domaine de la santé osseuse
Bruyère, Olivier ULg; Reginster, Jean-Yves ULg

in Ortho-Rhumato (2011), 9(6), 215

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See detailLa structure géométrique de l’ADN
Thiry, Marc ULg; Cloes, Marie

in Tangente (2011), 42

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See detailCompte rendu de C. Calame, Prométhée généticien, Paris, 2010
Delli Pizzi, Aurian ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (2011), 24

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See detailPlantons autrement: Code de conduite sur les plantes invasives (dépliant de vulgarisation)
Halford, Mathieu ULg; Heemers, Leen; Mathys, Catherine et al

Learning material (2011)

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See detailAssessment of Crohn’s disease activity by FDG-PET/CT through a novel quantitative approach.
SABOURY, B.; HUSTINX, Roland ULg; BROTHERS, B. et al

in Journal of Nuclear Medicine (The) (2011), 52(SUPPL), 284

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See detailInvestigating Hardy-Weinberg equilibrium in case-control or cohort studies or meta-analysis.
Ziegler, Andreas; Van Steen, Kristel ULg; Wellek, Stefan

in Breast Cancer Research and Treatment (2011), 128(1), 197-201

Yu et al. (Breast Cancer Res Treat 117:675-677, 2009) recently stated that testing for deviation from Hardy-Weinberg equilibrium (HWE) is necessary to identify systematic genotyping errors in case-control ... [more ▼]

Yu et al. (Breast Cancer Res Treat 117:675-677, 2009) recently stated that testing for deviation from Hardy-Weinberg equilibrium (HWE) is necessary to identify systematic genotyping errors in case-control studies. They criticized a meta-analytic study for the deviation from HWE in the case group of one study. The aim of this article is twofold. First, we derive recommendations on how to test for deviations from HWE in different study designs. Second, we develop a meta-analytic framework for assessing compatibility with HWE or measuring deviation from HWE. The authors sketch the possible reasons behind deviation from HWE and provide guidelines for proper investigation of HWE deviations in different study designs. The authors argue that the standard HWE chi(2) lack of fit test is logically flawed and provide a logically unflawed approach for measuring deviation from HWE using confidence intervals. The proposed method is applicable to meta-analyses of both case-control or cohort association studies. The proposed approach is illustrated using the meta-analysis criticized by Yu et al. Heterogeneity between studies can be assessed. The critique of Yu et al. to the article of Frank et al. (Breast Cancer Res Treat 111:139-144, 2008) can be refuted. Even more, validity of HWE can be proven for the pooled control sample. The authors advocate the use of a confidence interval-based approach to assess HWE. The latter should only be investigated in control populations. In multicenter studies or meta-analysis, deviation from HWE should be analyzed using a meta-analytic approach. [less ▲]

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See detailDensity of states of chaotic Andreev billiards
Kuipers, Jack; Engl, Thomas; Berkolaiko, Gregory et al

in PHYSICAL REVIEW B (2011), 83(19), 195316-21

Quantum cavities or dots have markedly different properties depending on whether their classical counterparts are chaotic or not. Connecting a superconductor to such a cavity leads to notable proximity ... [more ▼]

Quantum cavities or dots have markedly different properties depending on whether their classical counterparts are chaotic or not. Connecting a superconductor to such a cavity leads to notable proximity effects, particularly the appearance, predicted by random matrix theory, of a hard gap in the excitation spectrum of quantum chaotic systems. Andreev billiards are interesting examples of such structures built with superconductors connected to a ballistic normal metal billiard since each time an electron hits the superconducting part it is retroreflected as a hole (and vice versa). Using a semiclassical framework for systems with chaotic dynamics, we show how this reflection, along with the interference due to subtle correlations between the classical paths of electrons and holes inside the system, is ultimately responsible for the gap formation. The treatment can be extended to include the effects of a symmetry-breaking magnetic field in the normal part of the billiard or an Andreev billiard connected to two phase-shifted superconductors. Therefore, we are able to see how these effects can remold and eventually suppress the gap. Furthermore, the semiclassical framework is able to cover the effect of a finite Ehrenfest time, which also causes the gap to shrink. However, for intermediate values this leads to the appearance of a second hard gap-a clear signature of the Ehrenfest time. [less ▲]

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See detailLes Lais bretons moyen-anglais
Dor, Juliette ULg

Report (2011)

Review article of Colette Stévanovitch/ Anne Mathieu's volume of collected French translations (Turnhout : Brepols, 2010, 503 p., TVMA9). With contributions by Claire Vial, Hélène Dauby, Guy Bourquin ... [more ▼]

Review article of Colette Stévanovitch/ Anne Mathieu's volume of collected French translations (Turnhout : Brepols, 2010, 503 p., TVMA9). With contributions by Claire Vial, Hélène Dauby, Guy Bourquin, Philippe Mahoux-Pauzin, Jean-Jacques Blanchot, Marthe Mensah, Martine Yvernault, and the two editors. [less ▲]

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See detailLeukemic cell xenograft in zebrafish embryo for investigating drug efficacy.
Pruvot, Benoist ULg; Jacquel, Arnaud; Droin, Nathalie et al

in Haematologica (2011), 96(4), 612-6

Zebrafish were proposed as an alternative to mammalian models to assess the efficacy and toxicity of antileukemic drugs. Due to the limited number of transgenic zebrafish leukemia models, we explored ... [more ▼]

Zebrafish were proposed as an alternative to mammalian models to assess the efficacy and toxicity of antileukemic drugs. Due to the limited number of transgenic zebrafish leukemia models, we explored human leukemic cell xenograft in zebrafish embryos. Human leukemic cell lines and blast cells sorted from patients with acute myelogenous leukemia were injected 48 hours post-fertilization and remained in the circulation of zebrafish embryos for several days without affecting their development. Imatinib and oxaphorines did not demonstrate any toxicity on normal zebrafish embryos and decreased the leukemic burden in animals xenografted with sensitive leukemic cell lines. Two other molecules, all-trans retinoic acid and the translation inhibitor 4EGI-1, demonstrated teratogenic effects at concentrations shown to be efficient in vitro, which precluded investigation of their antileukemic activity in such models. Altogether, xenografted leukemic cells in zebrafish embryos are a pharmacologically relevant model for screening non-teratogenic drugs. [less ▲]

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