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See detailState of the Art of Existing Early Design Simulation Tools for Net Zero Energy Buildings: A Comparison of Ten Tools
Attia, Shady ULg

Report (2011)

Given the challenges to design Net Zero Energy Buildings (NZEBs) the use of Building Performance Simulation (BPS) tools during early design phases has been indispensable. In this context, BPS techniques ... [more ▼]

Given the challenges to design Net Zero Energy Buildings (NZEBs) the use of Building Performance Simulation (BPS) tools during early design phases has been indispensable. In this context, BPS techniques can be supportive when integrated early in the design process. However, architects suffer from BPS tools limitations during this decisive phase that addresses more the building geometry and envelope. To identify those limitations and as part of the International Energy Agency (IEA) Task 40: Towards Net Zero Energy Buildings, this report compares ten early design BPS tools. The aim is to define the potential of using and integrating the tools by architect during the design of NZEBs. The examined tools include HEED, e-Quest, ENERGY-10, Vasari, Solar Shoebox, Open Studio Plug-in, IES-VE- Ware, DesignBuilder, ECOTECT and BEopt. The comparison is based on five criteria including usability, optimization, interoperability, accuracy and design process integration of the tools. The results describe tools limitations and major requirements to meet the NZEBs objective implications. [less ▲]

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See detailTranssinusoidal portal vein embolization with ethylene vinyl alcool polymer ( onyx): a feasibility study in pigs
Smits Maarten; Vanlangenhove Peter; Sturm Emiel et al

in Cardiovascular & Interventional Radiology (2011)

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See detailAcetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase.
Guarani, Virginia; Deflorian, Gianluca; Franco, Claudio A et al

in Nature (2011), 473(7346), 234-8

Notch signalling is a key intercellular communication mechanism that is essential for cell specification and tissue patterning, and which coordinates critical steps of blood vessel growth. Although subtle ... [more ▼]

Notch signalling is a key intercellular communication mechanism that is essential for cell specification and tissue patterning, and which coordinates critical steps of blood vessel growth. Although subtle alterations in Notch activity suffice to elicit profound differences in endothelial behaviour and blood vessel formation, little is known about the regulation and adaptation of endothelial Notch responses. Here we report that the NAD(+)-dependent deacetylase SIRT1 acts as an intrinsic negative modulator of Notch signalling in endothelial cells. We show that acetylation of the Notch1 intracellular domain (NICD) on conserved lysines controls the amplitude and duration of Notch responses by altering NICD protein turnover. SIRT1 associates with NICD and functions as a NICD deacetylase, which opposes the acetylation-induced NICD stabilization. Consequently, endothelial cells lacking SIRT1 activity are sensitized to Notch signalling, resulting in impaired growth, sprout elongation and enhanced Notch target gene expression in response to DLL4 stimulation, thereby promoting a non-sprouting, stalk-cell-like phenotype. In vivo, inactivation of Sirt1 in zebrafish and mice causes reduced vascular branching and density as a consequence of enhanced Notch signalling. Our findings identify reversible acetylation of the NICD as a molecular mechanism to adapt the dynamics of Notch signalling, and indicate that SIRT1 acts as rheostat to fine-tune endothelial Notch responses. [less ▲]

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See detailPropédeutique dans l’espèce équine.
Amory, Hélène ULg

Learning material (2011)

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See detailTraining on the alert phone CPR protocol in belgium : evaluation of the dispatchers
El Fassi, Mehdi; Skivee, V.; STIPULANTE, Samuel ULg et al

in Acta Clinica Belgica (2011), 66(2), 9

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See detailfMRI Artefact Rejection and Sleep Scoring Toolbox
Leclercq, Yves ULg; Schrouff, Jessica ULg; Noirhomme, Quentin ULg et al

in Computational Intelligence & Neuroscience (2011)

This paper proposes a toolbox for handling large EEG/ MEG data sets, rejecting the artefact linked to joint fMRI-EEG acquisitions and scoring data sets.

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See detailENCYCLOPEDIA OF ASTROBIOLOGY
Gargaud, M.; Amils, R.; Cernichicaro et al

Book published by Springer (2011)

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See detailAction des cultures protectrices : cas des germes lactiques sur la flore alimentaire indésirable.
Privat, Kouakou; Thonart, Philippe ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2011), 15(2), 339-348

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See detailBelgian Report
Kohl, Benoît ULg; Imbrechts, L.; Mattei, P. et al

in Dutch Construction contracts: views from abroad (2011)

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See detailTranscranial magnetic stimulation-evoked EEG/cortical potentials in physiological and pathological aging.
Casarotto, Silvia; Maatta, Sara; Herukka, Sanna-Kaisa et al

in Neuroreport (2011), 22(12), 592-7

The frontal cortex undergoes macrostructural and microstructural changes across the lifespan. These changes can be entirely physiological, such as the ones occurring in elderly individuals who are ... [more ▼]

The frontal cortex undergoes macrostructural and microstructural changes across the lifespan. These changes can be entirely physiological, such as the ones occurring in elderly individuals who are cognitively intact, or pathological, such as the ones occurring in patients with Alzheimer's disease. Here, we use simultaneous electroencephalography (EEG) and transcranial magnetic stimulation (TMS) to study how the excitability of the frontal cortex changes during healthy and pathological aging. Hence, we compared the TMS-evoked EEG potentials collected in healthy elderly individuals with the ones collected in healthy young individuals, and in patients with Alzheimer's disease. We have shown that the EEG response to TMS of the left superior frontal cortex is not affected by physiological aging but is markedly altered by cognitive impairment. [less ▲]

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See detailRhoGDI alpha-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesis
Ho, Thi Thanh Giang ULg; Stultiens, Audrey; Dubail, Johanne ULg et al

in Molecular Biology of the Cell (2011), 22(17), 3263-75

RhoGTPases are key signaling molecules regulating main cellular functions such as migration, proliferation, survival, and gene expression through interactions with various effectors. Within the RhoA ... [more ▼]

RhoGTPases are key signaling molecules regulating main cellular functions such as migration, proliferation, survival, and gene expression through interactions with various effectors. Within the RhoA-related subclass, RhoA and RhoC contribute to several steps of tumor growth, and the regulation of their expression affects cancer progression. Our aim is to investigate their respective contributions to the acquisition of an invasive phenotype by using models of reduced or forced expression. The silencing of RhoC, but not of RhoA, increased the expression of genes encoding tumor suppressors, such as nonsteroidal anti-inflammatory drug-activated gene 1 (NAG-1), and decreased migration and the anchorage-independent growth in vitro. In vivo, RhoC small interfering RNA (siRhoC) impaired tumor growth. Of interest, the simultaneous knockdown of RhoC and NAG-1 repressed most of the siRhoC-related effects, demonstrating the central role of NAG-1. In addition of being induced by RhoC silencing, NAG-1 was also largely up-regulated in cells overexpressing RhoA. The silencing of RhoGDP dissociation inhibitor alpha (RhoGDIalpha) and the overexpression of a RhoA mutant unable to bind RhoGDIalpha suggested that the effect of RhoC silencing is indirect and results from the up-regulation of the RhoA level through competition for RhoGDIalpha. This study demonstrates the dynamic balance inside the RhoGTPase network and illustrates its biological relevance in cancer progression. [less ▲]

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See detailKarsts in silicated and non carbonated rocks
Willems, Luc ULg

Conference (2011)

Karsts in silicated and non carbonated rocks refer to morphologies similar to those found in limestones (caves, lapies, polje…) as being equally generated by predominantly dissolution processes. Their ... [more ▼]

Karsts in silicated and non carbonated rocks refer to morphologies similar to those found in limestones (caves, lapies, polje…) as being equally generated by predominantly dissolution processes. Their discovery in allegedly not very soluble rocks raises the question of existing water resources in lithologies which are rarely considered from this point of view. A rough inventory of this kind of karsts shows that they essentially develop in sandstones and quartzites. Other silicated lithologies such as granites or gneisses seem to contain only a few examples. Karsts in silicated and non carbonated rocks are found at all latitudes, though mainly in the warm and temperate climate zones of the world. Nevertheless, these conclusions may result from the lack of systematic prospecting in numerous regions of the world. Typically, most studied cavities are located in Paleozoic to Proterozoic rocks. Underground networks can stretch for several kilometers. Two types of cavities can be identified. The first one is characterized by cave entrances located in a cliff or in a raised hillside. These subhorizontal cavities end blind within the rock massif. No trace of fracturing authorizing mechanical erosion by flows, which would explain their genesis, was ever recorded. The second type of cavities is characterized by the presence of an underground stream which disappears in a siphon or in some impenetrable passages. In some cases, an important granular disintegration of the surrounding rock produces quantities of sand which seal large pre-existent voids. The latter were formed in different physico-chemical conditions than those present in the open air environment. An initial deep karstification is possible despite the surface environment. Secondary morphologies on the cave walls (alveoli, pillars of dissolution, passages with “key hole” section, ceiling bells …) enable us to partially reconstitute the genesis of these caves. It would start in a phreatic environment with the development of spots of dissolution along deep water circulations. Initially, independent cavities grow and interconnect to form embryonal karst networks. The incision of valleys and the weathering processes progressing from the surface can intersect these. Physical erosion then becomes more prominent than chemical erosion. The pre-existent forms, depending on their organization, can either be dismantled or contribute to the evolution of a complex karst network. A comprehensive study of karsts in silicated and non carbonated rocks is an opportunity to a better understanding of generally inaccessible deep karstification, including in the carbonated rocks. Moreover, the presence of these karsts and sometimes of underground rivers in regions hit by chronic droughts represents a potential of water resources disregarded today. [less ▲]

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See detailNZEB Definitions: current market status and certification in Belgium
Mlecnik; Attia, Shady ULg

Report (2011)

The recast of the European Performance of Buildings Directive (EPBD) requires the uptake of a definition of so called ‘nearly zero energy’ buildings (nZEB). Belgium was first to set a definition for a ... [more ▼]

The recast of the European Performance of Buildings Directive (EPBD) requires the uptake of a definition of so called ‘nearly zero energy’ buildings (nZEB). Belgium was first to set a definition for a ‘net zero energy house’ (NZEB) in 2009. Every year the definition is revised for consistency with shortcomings and emerging issues. The Belgian definition raised many questions regarding (1) the net balance, (2) the application and calculation method (3) the indoor air quality and comfort, (4) energy use included in the balance, (5) the type of buildings, (6) the accepted renewable energy supply options, (7) the quality assurance and monitoring and (8) energy storage and the connection to the energy infrastructure. Therefore, the paper presents a review on the current Belgian definition and its market status in comparison with the international context. The aim of the paper is to review current definition discussions and pave the way to a more consistent definition. [less ▲]

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See detailNuclear delivery of a therapeutic peptide by long circulating pH-sensitive liposomes: Benefits over classical vesicles.
Ducat, Emilie ULg; Deprez, Julie ULg; Gillet, Aline ULg et al

in International Journal of Pharmaceutics (2011)

The purpose of this study is to propose a suitable vector combining increased circulation lifetime and intracellular delivery capacities for a therapeutic peptide. Long circulating classical liposomes ... [more ▼]

The purpose of this study is to propose a suitable vector combining increased circulation lifetime and intracellular delivery capacities for a therapeutic peptide. Long circulating classical liposomes [SPC:CHOL:PEG-750-DSPE (47:47:6 molar% ratio)] or pH-sensitive stealth liposomes [DOPE:CHEMS:CHOL:PEG(750)-DSPE (43:21:30:6 molar% ratio)] were used to deliver a therapeutic peptide to its nuclear site of action. The benefit of using stealth pH-sensitive liposomes was investigated and formulations were compared to classical liposomes in terms of size, shape, charge, encapsulation efficiency, stability and, most importantly, in terms of cellular uptake. Confocal microscopy and flow cytometry were used to evaluate the intracellular fate of liposomes themselves and of their hydrophilic encapsulated material. Cellular uptake of peptide-loaded liposomes was also investigated in three cell lines: Hs578t human epithelial cells from breast carcinoma, MDA-MB-231 human breast carcinoma cells and WI-26 human diploid lung fibroblast cells. The difference between formulations in terms of peptide delivery from the endosome to the cytoplasm and even to the nucleus was investigated as a function of time. Characterization studies showed that both formulations possess acceptable size, shape and encapsulation efficiency but cellular uptake studies showed the important benefit of the pH-sensitive formulation over the classical one, in spite of liposome PEGylation. Indeed, stealth pH-sensitive liposomes were able to deliver hydrophilic materials strongly to the cytoplasm. Most importantly, when encapsulated in pH-sensitive stealth liposomes, the peptide was able to reach the nucleus of tumorigenic and non tumorigenic breast cancer cells. [less ▲]

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See detailEnjeux autour de la survie de l'Assemblée de l'Union de l'Europe occidentale : tensions, rivalités et contournements
Dumoulin, André ULg

in Wintgens, Sophie; Grégory, Piet (Eds.) La puissance : débat autour des jeux et des enjeux du pouvoir (2011)

Examen des rivalités et des résistances de l'Assemblée de l'UEO face à la décision de dénoncer le traité de Bruxelles modifié

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See detailTrend evolution and seasonal variation of tropospheric and stratospheric carbonyl sulfide (OCS) above Jungfraujoch
Lejeune, Bernard ULg; Mahieu, Emmanuel ULg; Duchatelet, Pierre ULg et al

in Geophysical Research Abstracts (2011), 13

Carbonyl sulfide (OCS) is the most abundant sulfur-containing trace gas in the atmosphere and accounts for a substantial portion of the sulfur in the stratospheric aerosol layer which influences the ... [more ▼]

Carbonyl sulfide (OCS) is the most abundant sulfur-containing trace gas in the atmosphere and accounts for a substantial portion of the sulfur in the stratospheric aerosol layer which influences the Earth’s radiation budget and stratospheric ozone chemistry. The major identified OCS sources are oceans and anthropogenic emissions, while atmospheric loss and uptake by vegetation and soils constitute the main OCS sinks. The uptake by vegetation strongly influences the distribution and seasonality of OCS throughout most of the Northern Hemisphere, just like for CO2. Montzka et al. (2007) pointed that atmospheric OCS measurements have the potential to constrain the biomass Gross Primary Production (GPP). Unfortunately, there remain large uncertainties on some components strengths of the atmospheric OCS budget. A recent work by Suntharalingam et al. (2008) showed that uptake by plants has been strongly underestimated in actual balanced budgets, suggesting that additional significant OCS sources have still to be identified. In order to improve our understanding of the different processes governing seasonal and inter-annual OCS variability, a new approach has been developed and optimized, using the SFIT-2 algorithm, to retrieve atmospheric abundance of OCS from high-resolution ground-based infrared solar spectra. Our observations are recorded on a regular basis with Fourier Transform Infrared spectrometers (FTIRs), under clear-sky conditions, at the NDACC site (Network for the Detection of Atmospheric Composition Change, http://www.ndacc.org) of the International Scientific Station of the Jungfraujoch (Swiss Alps, 46.5°N, 8.0°E, 3580m asl). Information content analysis of the retrieved OCS products shows us that we are able to distinguish between tropospheric and stratospheric partial column contributions for this species. Thanks to our unique observational database, we have produced an updated OCS long-term trend from 1995 to 2010, representative for both the troposphere and stratosphere at northern mid-latitudes. In this contribution, we will present and critically discuss the recent OCS trend evolution, in particular the end of the slow decline of its abundance observed in 2002 and the maximum reached in 2008. In addition to the OCS inter-annual variations, we will analyze the OCS seasonal cycle during the 15 last years. We will also compare our results with simulations of seasonal OCS variations issued from a 3D global atmospheric chemical transport model (CTM), in order to try to quantify the individual contribution of the various processes playing a role in the Jungfraujoch OCS variability and influencing its atmospheric abundance. [less ▲]

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See detailCharacterization of a knock-down mutant deficient for isocitrate lyase in Chlamydomonas reinhardtii
Remacle, Claire ULg

in Microorganisms for bio-fuel production from sunlight, ESF conference (2011)

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