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See detailA new benzotriazole-mediated stereoflexible gateway to hetero-2,5-diketopiperazines
Monbaliu, Jean-Christophe ULg; Hansen, Finn; Beagle, Lucas et al

in Chemistry : A European Journal (2011), 18

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See detailA coupled two-scale computational scheme for the failure of periodic quasi-brittle thin planar shells and its application to masonry
Mercatoris, Benoît ULg; Massart, T. J.

in International Journal for Numerical Methods in Engineering (2011), 85(9), 1177-1206

This paper presents a multi-scale framework for the failure of periodic quasi-brittle thin planar shells. The failure behavior of textured or periodic heterogeneous materials is strongly influenced by ... [more ▼]

This paper presents a multi-scale framework for the failure of periodic quasi-brittle thin planar shells. The failure behavior of textured or periodic heterogeneous materials is strongly influenced by their mesostructure. Their periodicity and the quasi-brittle nature of their constituents result in complex behaviors such as damage-induced anisotropy properties with localization of damage, which are difficult to model by means of macroscopic closed-form constitutive laws. A computational homogenization procedure is used for the in-plane and out-of-plane behavior of such planar shells, and is combined with an acoustic tensor-based failure detection adapted to shell kinematics to detect the structural-scale failure. Based on an assumption of single period failure, the localization of damage at the structural scale is represented by means of mesostructurally informed embedded strong discontinuities incorporated in the macroscopic shell description. A new enhanced scale transition is outlined for shell failure, based on an approximate energy consistency argument to objectively upscale the energy dissipation. The corresponding multi-scale framework results are compared with direct fine-scale modeling results used as a reference for the case of masonry, showing good agreement in terms of the load-bearing capacity, of failure mechanisms and of associated energy dissipation. © 2010 John Wiley & Sons, Ltd. [less ▲]

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See detailInventaire des archives de la Société anonyme métallurgique d'Espérance-Longdoz (1806-1971)
Delvaux, Anne-Catherine ULg

Book published by Archives générales du Royaume (2011)

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See detailBilinguisme grec-latin et trinlinguisme grec-latin-copte en Égypte : Bibliographie générale
Carlig, Nathan ULg; Rochette, Bruno ULg

Textual, factual or bibliographical database (2011)

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See detailTelomere deregulations possess cytogenetic, phenotype, and prognostic specificities in acute leukemias.
CAPRARO, Valérie ULg; Zane, Linda; Poncet, Delphine et al

in Experimental Hematology (2011), 39(2), 195-2022

OBJECTIVE: Telomeres are protected by tightly regulated factors and elongated by telomerase. Short and/or deprotected chromosomes are recombinogenic and thereby cancer prone. MATERIALS AND METHODS ... [more ▼]

OBJECTIVE: Telomeres are protected by tightly regulated factors and elongated by telomerase. Short and/or deprotected chromosomes are recombinogenic and thereby cancer prone. MATERIALS AND METHODS: Together with the quantification of telomerase activity (TA), measuring telomere length (TL) and expression of the genes that govern telomere protection and elongation are useful for assessing telomere homeostasis. RESULTS: By these means we demonstrate that TL, hTERT, and TA are in the order acute myelogenous leukemia (AML) > T-cell acute lymphoblastic leukemia (T-ALL) > B-cell acute lymphoblastic leukemia (B-ALL) > T-ALL > AML, and B-ALL > AML > T-ALL. AML0 and AML3 display the lowest amounts of hTERT transcripts, and ALL and AML cells with cytogenetic abnormalities possess the shortest telomeres. hTERT expression includes phenotype-specific RNA maturation and correlates with TA but not with TL. A wide ratio of TA to hTERT expression between leukemia subtypes suggests phenotype-specific hTERT post-transcriptional deregulations. B- and T-ALL overexpress Ku70 and Pinx1, T-ALL PTOP and RAP1, and B-ALL TRF2, the expression of which is significantly higher in cases with abnormal karyotype. hTERT transcription and TL correlate with response to intensive chemotherapy, and hTERT and RAD50 are independent prognostic factors for survival. CONCLUSIONS: Each leukemia subtype possesses specific telomere dysregulations that rely on phenotype, karyotype, response to treatment, and survival. [less ▲]

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See detailThe mechanosensitivity of cells in joint tissues: Role in the pathogenesis of joint diseases
Sanchez, Christelle ULg; Mathy, Marianne ULg; Henrotin, Yves ULg

in Kamkin, André; Kiseleva, Irina (Eds.) Mechanosensitivity and Mechanotransduction (2011)

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See detailObliged permanent pastures : main future of ruminant production in Belgium
Stilmant, Didier; Stassart, Pierre M ULg; Peeters, Pierre et al

in Grassland Science in Europe (2011), 16

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See detailExiste-t-il des communautés sur Internet ? La réponse de trois études du mouvement du logiciel libre
Lejeune, Christophe ULg

in Actes des travaux du comité de recherche « Sociologie de la communication » (2011)

L'Open Directory Project, Debian et Wikipedia sont trois collectifs issus du mouvement du logiciel libre. Leur comparaison permet de dégager les traits communs et les différences d'organisation sociale de ... [more ▼]

L'Open Directory Project, Debian et Wikipedia sont trois collectifs issus du mouvement du logiciel libre. Leur comparaison permet de dégager les traits communs et les différences d'organisation sociale de ces trois collectifs médiatisés par la technologie.Nous examinons dans quelle mesure ces éléments empiriques s'accordent avec les définitions classiques de communauté (fut-elle virtuelle). Nous interrogeons dès lors l'opportunité de caractériser ces phénomènes au moyen d'une telle notion et identifiant deux alternatives : soit modifier les définitions classiques, soit proposer de nouvelles notions. Finalement, nous proposons la notion plus adéquate de collectifs médiatisés orientés vers un projet. [less ▲]

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See detailAssessment of Crohn’s disease activity by FDG-PET/CT through a novel quantitative approach.
SABOURY, B.; HUSTINX, Roland ULg; BROTHERS, B. et al

in Journal of Nuclear Medicine (The) (2011), 52(SUPPL), 284

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See detailHTLV-1 propels thymic human T cell development in "human immune system" Rag2(-)/(-) gamma c(-)/(-) mice.
Villaudy, Julien; Wencker, Melanie; Gadot, Nicolas et al

in PLoS Pathogens (2011), 7(9), 1002231

Alteration of early haematopoietic development is thought to be responsible for the onset of immature leukemias and lymphomas. We have previously demonstrated that Tax(HTLV-1) interferes with ss-selection ... [more ▼]

Alteration of early haematopoietic development is thought to be responsible for the onset of immature leukemias and lymphomas. We have previously demonstrated that Tax(HTLV-1) interferes with ss-selection, an important checkpoint of early thymopoiesis, indicating that human T-cell leukemia virus type 1 (HTLV-1) infection has the potential to perturb thymic human alphabeta T-cell development. To verify that inference and to clarify the impact of HTLV-1 infection on human T-cell development, we investigated the in vivo effects of HTLV-1 infection in a "Human Immune System" (HIS) Rag2(-)/(-)gamma(c)(-)/(-) mouse model. These mice were infected with HTLV-1, at a time when the three main subpopulations of human thymocytes have been detected. In all but two inoculated mice, the HTLV-1 provirus was found integrated in thymocytes; the proviral load increased with the length of the infection period. In the HTLV-1-infected mice we observed alterations in human T-cell development, the extent of which correlated with the proviral load. Thus, in the thymus of HTLV-1-infected HIS Rag2(-)/(-)gammac(-)/(-) mice, mature single-positive (SP) CD4(+) and CD8(+) cells were most numerous, at the expense of immature and double-positive (DP) thymocytes. These SP cells also accumulated in the spleen. Human lymphocytes from thymus and spleen were activated, as shown by the expression of CD25: this activation was correlated with the presence of tax mRNA and with increased expression of NF-kB dependent genes such as bfl-1, an anti-apoptotic gene, in thymocytes. Finally, hepato-splenomegaly, lymphadenopathy and lymphoma/thymoma, in which Tax was detected, were observed in HTLV-1-infected mice, several months after HTLV-1 infection. These results demonstrate the potential of the HIS Rag2(-)/(-)gamma(c)(-)/(-) animal model to elucidate the initial steps of the leukemogenic process induced by HTLV-1. [less ▲]

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See detailDensity of states of chaotic Andreev billiards
Kuipers, Jack; Engl, Thomas; Berkolaiko, Gregory et al

in PHYSICAL REVIEW B (2011), 83(19), 195316-21

Quantum cavities or dots have markedly different properties depending on whether their classical counterparts are chaotic or not. Connecting a superconductor to such a cavity leads to notable proximity ... [more ▼]

Quantum cavities or dots have markedly different properties depending on whether their classical counterparts are chaotic or not. Connecting a superconductor to such a cavity leads to notable proximity effects, particularly the appearance, predicted by random matrix theory, of a hard gap in the excitation spectrum of quantum chaotic systems. Andreev billiards are interesting examples of such structures built with superconductors connected to a ballistic normal metal billiard since each time an electron hits the superconducting part it is retroreflected as a hole (and vice versa). Using a semiclassical framework for systems with chaotic dynamics, we show how this reflection, along with the interference due to subtle correlations between the classical paths of electrons and holes inside the system, is ultimately responsible for the gap formation. The treatment can be extended to include the effects of a symmetry-breaking magnetic field in the normal part of the billiard or an Andreev billiard connected to two phase-shifted superconductors. Therefore, we are able to see how these effects can remold and eventually suppress the gap. Furthermore, the semiclassical framework is able to cover the effect of a finite Ehrenfest time, which also causes the gap to shrink. However, for intermediate values this leads to the appearance of a second hard gap-a clear signature of the Ehrenfest time. [less ▲]

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See detailZu den Grenzen des EuroCom-Konzeptes für EuroComGerm - Zwischenfazit
Berthele, Raphael; Colliander, Peter; Duke, Janet et al

in Pöckl, Wolfgang; Ohnheiser, Ingeborg; Sandrini, Peter (Eds.) Translation – Sprachvariation – Mehrsprachigkeit: : Festschrift für Lew Zybatow zum 60. Geburtstag (2011)

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See detailAn insight into normal and pathological pregnancies using large-scale microarrays: lessons from microarrays
Chaouat, G. R.; Rodde, N.; Petitbarat, M. et al

in Journal of Reproductive Immunology (2011), 89(2), 163-72

In the introduction, we briefly recall old but classic evidence that there is no tolerance to paternal alloantigens in a first pregnancy. Therefore, we performed small- and large-scale microarrays in CBA ... [more ▼]

In the introduction, we briefly recall old but classic evidence that there is no tolerance to paternal alloantigens in a first pregnancy. Therefore, we performed small- and large-scale microarrays in CBA × DBA/2 and CBA × BALB/c combinations, recently described as a murine model for preeclampsia. Our results are in line with other data suggesting a very early deregulation of local immune vascular events rather than a break of immune tolerance. Other data presented at the Tioman 2010 Preeclampsia Workshop supporting this hypothesis are briefly summarised, as well as indications and caveats from a recent human microarray on implantation failure and recurrent pregnancy loss. [less ▲]

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See detailA computational solid and fluid mechanical analysis of CAD-versus micro-CT-based models of regular Ti6Al4V scaffolds for bone tissue engineering
Truscello, Silvia; Kerckhofs, Greet ULg; Moesen, Maarten et al

in Histology and Histopathology (2011)

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