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See detailA new benzotriazole-mediated stereoflexible gateway to hetero-2,5-diketopiperazines
Monbaliu, Jean-Christophe ULg; Hansen, Finn; Beagle, Lucas et al

in Chemistry : A European Journal (2011), 18

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See detailA coupled two-scale computational scheme for the failure of periodic quasi-brittle thin planar shells and its application to masonry
Mercatoris, Benoît ULg; Massart, T. J.

in International Journal for Numerical Methods in Engineering (2011), 85(9), 1177-1206

This paper presents a multi-scale framework for the failure of periodic quasi-brittle thin planar shells. The failure behavior of textured or periodic heterogeneous materials is strongly influenced by ... [more ▼]

This paper presents a multi-scale framework for the failure of periodic quasi-brittle thin planar shells. The failure behavior of textured or periodic heterogeneous materials is strongly influenced by their mesostructure. Their periodicity and the quasi-brittle nature of their constituents result in complex behaviors such as damage-induced anisotropy properties with localization of damage, which are difficult to model by means of macroscopic closed-form constitutive laws. A computational homogenization procedure is used for the in-plane and out-of-plane behavior of such planar shells, and is combined with an acoustic tensor-based failure detection adapted to shell kinematics to detect the structural-scale failure. Based on an assumption of single period failure, the localization of damage at the structural scale is represented by means of mesostructurally informed embedded strong discontinuities incorporated in the macroscopic shell description. A new enhanced scale transition is outlined for shell failure, based on an approximate energy consistency argument to objectively upscale the energy dissipation. The corresponding multi-scale framework results are compared with direct fine-scale modeling results used as a reference for the case of masonry, showing good agreement in terms of the load-bearing capacity, of failure mechanisms and of associated energy dissipation. © 2010 John Wiley & Sons, Ltd. [less ▲]

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See detailInventaire des archives de la Société anonyme métallurgique d'Espérance-Longdoz (1806-1971)
Delvaux, Anne-Catherine ULg

Book published by Archives générales du Royaume (2011)

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See detailLe droit de la construction
Kohl, Benoît ULg

Book published by Anthemis (2011)

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See detailTelomere deregulations possess cytogenetic, phenotype, and prognostic specificities in acute leukemias.
CAPRARO, Valérie ULg; Zane, Linda; Poncet, Delphine et al

in Experimental Hematology (2011), 39(2), 195-2022

OBJECTIVE: Telomeres are protected by tightly regulated factors and elongated by telomerase. Short and/or deprotected chromosomes are recombinogenic and thereby cancer prone. MATERIALS AND METHODS ... [more ▼]

OBJECTIVE: Telomeres are protected by tightly regulated factors and elongated by telomerase. Short and/or deprotected chromosomes are recombinogenic and thereby cancer prone. MATERIALS AND METHODS: Together with the quantification of telomerase activity (TA), measuring telomere length (TL) and expression of the genes that govern telomere protection and elongation are useful for assessing telomere homeostasis. RESULTS: By these means we demonstrate that TL, hTERT, and TA are in the order acute myelogenous leukemia (AML) > T-cell acute lymphoblastic leukemia (T-ALL) > B-cell acute lymphoblastic leukemia (B-ALL) > T-ALL > AML, and B-ALL > AML > T-ALL. AML0 and AML3 display the lowest amounts of hTERT transcripts, and ALL and AML cells with cytogenetic abnormalities possess the shortest telomeres. hTERT expression includes phenotype-specific RNA maturation and correlates with TA but not with TL. A wide ratio of TA to hTERT expression between leukemia subtypes suggests phenotype-specific hTERT post-transcriptional deregulations. B- and T-ALL overexpress Ku70 and Pinx1, T-ALL PTOP and RAP1, and B-ALL TRF2, the expression of which is significantly higher in cases with abnormal karyotype. hTERT transcription and TL correlate with response to intensive chemotherapy, and hTERT and RAD50 are independent prognostic factors for survival. CONCLUSIONS: Each leukemia subtype possesses specific telomere dysregulations that rely on phenotype, karyotype, response to treatment, and survival. [less ▲]

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See detailPreliminary experience of a modified Maquet technique for repair of cranial cruciate ligament rupture in dogs
Etchepareborde, Sébastien; Brunel, Laurencie ULg; Bolen, Géraldine ULg et al

in Veterinary and Comparative Orthopaedics and Traumatology (2011)

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See detailTransient Fokker-Planck Equation solved with SPH
Canor, Thomas ULg; Denoël, Vincent ULg

in Proceedings of the 5th International Conference on Advanced Computational Methods in Engineering (2011)

In many engineering matters, systems are submitted to random excitations. Probabilistic theories aim at describing the properties of a system by means of statistical properties such as probability density ... [more ▼]

In many engineering matters, systems are submitted to random excitations. Probabilistic theories aim at describing the properties of a system by means of statistical properties such as probability density function (pdf). For a deterministic system randomly excited, the evolution of its pdf is commonly described with Fokker-Planck-Kolmogorov equation (FPK). The FPK equation is a conservation equation of a hypothetical fluid, which represents physically the transport of probability. To solve this equation, Smoothed Particle Hydrodynamics (SPH) are used: the system is modelled with a conservation equation for the system and a transport equation for each particle. Numerical implementation shows the superiority of this method over many other mesh-based methods: (i) the conservation of total probability in the state space is explicitly written, (ii) no specific boundary conditions must be imposed if an adaptive smoothing length is chosen and if particles are initially regularly spread out, (iii) the positivity of the pdf is ensured. Furthermore, thanks to the moving particles, this method is adapted for a large kind of initial conditions (quasi-deterministic or even discontinuous). The FPK equation can be solved without any a priori knowledge of the stationary distribution; just a precise representation of the initial distribution is required. [less ▲]

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See detailAssessment of Crohn’s disease activity by FDG-PET/CT through a novel quantitative approach.
SABOURY, B.; HUSTINX, Roland ULg; BROTHERS, B. et al

in Journal of Nuclear Medicine (The) (2011), 52(SUPPL), 284

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See detailAlternatives medicamenteuses aux statines.
SCHEEN, André ULg

in Revue du Praticien (La) (2011), 61(8), 1121-2

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See detailDensity of states of chaotic Andreev billiards
Kuipers, Jack; Engl, Thomas; Berkolaiko, Gregory et al

in PHYSICAL REVIEW B (2011), 83(19), 195316-21

Quantum cavities or dots have markedly different properties depending on whether their classical counterparts are chaotic or not. Connecting a superconductor to such a cavity leads to notable proximity ... [more ▼]

Quantum cavities or dots have markedly different properties depending on whether their classical counterparts are chaotic or not. Connecting a superconductor to such a cavity leads to notable proximity effects, particularly the appearance, predicted by random matrix theory, of a hard gap in the excitation spectrum of quantum chaotic systems. Andreev billiards are interesting examples of such structures built with superconductors connected to a ballistic normal metal billiard since each time an electron hits the superconducting part it is retroreflected as a hole (and vice versa). Using a semiclassical framework for systems with chaotic dynamics, we show how this reflection, along with the interference due to subtle correlations between the classical paths of electrons and holes inside the system, is ultimately responsible for the gap formation. The treatment can be extended to include the effects of a symmetry-breaking magnetic field in the normal part of the billiard or an Andreev billiard connected to two phase-shifted superconductors. Therefore, we are able to see how these effects can remold and eventually suppress the gap. Furthermore, the semiclassical framework is able to cover the effect of a finite Ehrenfest time, which also causes the gap to shrink. However, for intermediate values this leads to the appearance of a second hard gap-a clear signature of the Ehrenfest time. [less ▲]

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See detailL’évaluation de la réflexivité dans des portfolios électroniques dans le cadre d’un cours de Soins Palliatifs en formation médicale de base
Giet, Didier ULg; MASSART, Valérie ULg; Deum, Mélanie ULg et al

Conference (2011)

Le cours de Médecine Palliative est organisé en avant-dernière année des études médicales de 2e cycle par deux enseignants, Médecin Généraliste et Médecin Hospitalier. Ce cours a été dispensé pendant 10 ... [more ▼]

Le cours de Médecine Palliative est organisé en avant-dernière année des études médicales de 2e cycle par deux enseignants, Médecin Généraliste et Médecin Hospitalier. Ce cours a été dispensé pendant 10 ans selon un format traditionnel ex cathedra. Il était dispensé par de nombreux intervenants pluridisciplinaires. Une évaluation des enseignements a montré que les étudiants jugeaient les interventions trop théoriques, sans lien avec leurs questions et préoccupations. En conséquence, c’est la discipline « Médecine Palliative et de Soins de Vie » qui ne suscitaient pas d’intérêt. De nouveaux objectifs et de nouvelles modalités pédagogiques ont été introduits en 2010-2011 à l’attention de 100 étudiants. L’objectif principal est le développement chez les étudiants d’une attitude réflexive face à la discipline « Médecine Palliative ». Les outils pédagogiques introduits dans le dispositif sont le portfolio électronique, une vignette clinique évolutive, l’accompagnement à distance de chaque étudiant par un tuteur, des cours en présentiel. La pratique réflexive de chaque étudiant est évaluée au terme du dispositif, conjointement par les 2 enseignants sur base de critères et d’indicateurs. Voici une illustration des critères utilisés : - Intensité des interactions dans le carnet d’apprentissage électronique (et aux cours) - Pertinence des interventions - Engagement dans la tâche - Capacité réflexive (pertinence de l’analyse et de la régulation de la situation décrite dans la vignette) - Qualité de l’auto-évaluation et identification des éléments déclencheurs de progrès - Degré d’apprentissage (Bilan d’atteinte des objectifs fixés par le cours et décrits) La communication orale présentera le dispositif d’évaluation, les critères et les indicateurs utilisés, les premiers résultats de l’évaluation des étudiants, les perspectives de régulation du dispositif d’évaluation. [less ▲]

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See detailAnalyse des pigments des dessins pariétaux de la grotte Chauvet à Vallon-Pont-d'Arc
Laval, Eric; Salomon, Hélène ULg; Vignaud, Colette et al

Conference (2011)

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See detailTaking "Pragmatic Dimensions" of ontologies into account: Frameworks
Giboin, Alain; Denis, Brigitte ULg; Snoeck, Céline ULg

in Proceedings of the 7th International Conference on Semantic Systems Proceedings (2011)

A major aim of the Pragmatic Web is “to support communities to put ontologies in context”. As a contribution to this aim, we present the framework we developed to analyze the way we attempted to ... [more ▼]

A major aim of the Pragmatic Web is “to support communities to put ontologies in context”. As a contribution to this aim, we present the framework we developed to analyze the way we attempted to contextualize the ontologies underlying a set of semantic knowledge services dedicated to communities of practice. The framework was derived from the “Ontology Framework” elaborated by members of the Ontology Engineering community during the Ontology Summit 2007. Both frameworks define a series of “pragmatic dimensions” of ontologies. Because our derived framework does not cover all possible dimensions, we propose to complement it, by relying on existing work from the Ontology Engineering community in general, and from the Pragmatic Web community in particular. In conclusion, we invite the Pragmatic Web community to pursue such a work by jointly elaborating a consensual “Pragmatic Ontology Framework”. [less ▲]

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See detailAtomic oxygen distributions in the Venus thermosphere: Comparisons between Venus Express observations and global model simulations
Brecht, A.; Bougher, S. W.; Gérard, Jean-Claude ULg et al

in Icarus: International Journal of Solar System Studies (2011)

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See detailThe use of micro-CT to correlate in-vitro cell behaviour with the surface roughness of Ti6Al4V scaffolds for tissue engineering
Pyka, Grzegorz; Kerckhofs, Greet ULg; Chai, Yoke Chin et al

in Abstract book SkyScan User Meeting 2011 (2011)

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See detailA computational solid and fluid mechanical analysis of CAD-versus micro-CT-based models of regular Ti6Al4V scaffolds for bone tissue engineering
Truscello, Silvia; Kerckhofs, Greet ULg; Moesen, Maarten et al

in Histology and Histopathology (2011)

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