References of "2011"
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See detailTelomere deregulations possess cytogenetic, phenotype, and prognostic specificities in acute leukemias.
CAPRARO, Valérie ULg; Zane, Linda; Poncet, Delphine et al

in Experimental Hematology (2011), 39(2), 195-2022

OBJECTIVE: Telomeres are protected by tightly regulated factors and elongated by telomerase. Short and/or deprotected chromosomes are recombinogenic and thereby cancer prone. MATERIALS AND METHODS ... [more ▼]

OBJECTIVE: Telomeres are protected by tightly regulated factors and elongated by telomerase. Short and/or deprotected chromosomes are recombinogenic and thereby cancer prone. MATERIALS AND METHODS: Together with the quantification of telomerase activity (TA), measuring telomere length (TL) and expression of the genes that govern telomere protection and elongation are useful for assessing telomere homeostasis. RESULTS: By these means we demonstrate that TL, hTERT, and TA are in the order acute myelogenous leukemia (AML) > T-cell acute lymphoblastic leukemia (T-ALL) > B-cell acute lymphoblastic leukemia (B-ALL) > T-ALL > AML, and B-ALL > AML > T-ALL. AML0 and AML3 display the lowest amounts of hTERT transcripts, and ALL and AML cells with cytogenetic abnormalities possess the shortest telomeres. hTERT expression includes phenotype-specific RNA maturation and correlates with TA but not with TL. A wide ratio of TA to hTERT expression between leukemia subtypes suggests phenotype-specific hTERT post-transcriptional deregulations. B- and T-ALL overexpress Ku70 and Pinx1, T-ALL PTOP and RAP1, and B-ALL TRF2, the expression of which is significantly higher in cases with abnormal karyotype. hTERT transcription and TL correlate with response to intensive chemotherapy, and hTERT and RAD50 are independent prognostic factors for survival. CONCLUSIONS: Each leukemia subtype possesses specific telomere dysregulations that rely on phenotype, karyotype, response to treatment, and survival. [less ▲]

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See detailLe melanome du sujet age.
Franchimont, Claudine ULg; PIERARD, Gérald ULg

in Revue Médicale de Liège (2011), 66(1), 34-40

Malignant melanoma developed after 60 years of age is not a rare neoplasm. It is mainly but not exclusively represented by the lentigo maligna (LM) and the invasive melanoma developed on LM (LMM). Men are ... [more ▼]

Malignant melanoma developed after 60 years of age is not a rare neoplasm. It is mainly but not exclusively represented by the lentigo maligna (LM) and the invasive melanoma developed on LM (LMM). Men are more often affected, and chronic sun exposure is the main cause. The diagnosis relies on the clinical, dermoscopic and dermatopathologic examinations. Surgical excision is recommended but alternative treatments are possible in case of contra-indication. [less ▲]

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See detailGonadal pathology and tumor risk in relation to clinical characteristics in patients with 45,X/46,XY mosaicism
Cools, M.; Pleskacova, J.; Stoop, H. et al

in Journal of Clinical Endocrinology and Metabolism (2011), 96(7), 1171-1180

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See detailDiastematomyelia: pre- and postnatal multimodal diagnostic approach.
Passoglou, V.; Tebache, M.; Collignon, L. et al

in Journal Belge de Radiologie (1924) (2011), 94(6), 333-5

Diastematomyelia is a relatively rare congenital abnormality presenting as a sagittal separation of the spinal cord. Although cases of diastematomyelia have been previously reported, fully documented ... [more ▼]

Diastematomyelia is a relatively rare congenital abnormality presenting as a sagittal separation of the spinal cord. Although cases of diastematomyelia have been previously reported, fully documented approaches by both prenatal and postnatal diagnostic workup are rare in the literature. We present a fully studied case of diastematomyelia type I investigated by prenatal US and MRI and postnatal US, MRI and radiography. [less ▲]

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See detailAssessment of Crohn’s disease activity by FDG-PET/CT through a novel quantitative approach.
SABOURY, B.; HUSTINX, Roland ULg; BROTHERS, B. et al

in Journal of Nuclear Medicine (The) (2011), 52(SUPPL), 284

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See detailCobalt-mediated radical copolymerization of conjugated and non-conjugated monomers
Hurtgen, Marie ULg; Debuigne, Antoine ULg; Fustin, Charles-André et al

in Polymer Preprints (2011), 52(2), 626-627

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See detailDensity of states of chaotic Andreev billiards
Kuipers, Jack; Engl, Thomas; Berkolaiko, Gregory et al

in PHYSICAL REVIEW B (2011), 83(19), 195316-21

Quantum cavities or dots have markedly different properties depending on whether their classical counterparts are chaotic or not. Connecting a superconductor to such a cavity leads to notable proximity ... [more ▼]

Quantum cavities or dots have markedly different properties depending on whether their classical counterparts are chaotic or not. Connecting a superconductor to such a cavity leads to notable proximity effects, particularly the appearance, predicted by random matrix theory, of a hard gap in the excitation spectrum of quantum chaotic systems. Andreev billiards are interesting examples of such structures built with superconductors connected to a ballistic normal metal billiard since each time an electron hits the superconducting part it is retroreflected as a hole (and vice versa). Using a semiclassical framework for systems with chaotic dynamics, we show how this reflection, along with the interference due to subtle correlations between the classical paths of electrons and holes inside the system, is ultimately responsible for the gap formation. The treatment can be extended to include the effects of a symmetry-breaking magnetic field in the normal part of the billiard or an Andreev billiard connected to two phase-shifted superconductors. Therefore, we are able to see how these effects can remold and eventually suppress the gap. Furthermore, the semiclassical framework is able to cover the effect of a finite Ehrenfest time, which also causes the gap to shrink. However, for intermediate values this leads to the appearance of a second hard gap-a clear signature of the Ehrenfest time. [less ▲]

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See detailDevelopment and validation of a LC method for the enantiomeric purity determination of S-ropivacaine in a pharmaceutical formulation using a recently commercialized cellulose-based chiral stationary phase and polar non-aqueous mobile phase.
Dossou, Katina Sourou Sylvestre ULg; CHIAP, Patrice ULg; Servais, Anne-Catherine ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (2011), 54(4), 687-93

Ropivacaine is the first enantiomerically pure long-acting local anaesthetic used for surgical anaesthesia and post-operative pain relief. A liquid chromatographic (LC) method using acetonitrile as the ... [more ▼]

Ropivacaine is the first enantiomerically pure long-acting local anaesthetic used for surgical anaesthesia and post-operative pain relief. A liquid chromatographic (LC) method using acetonitrile as the main solvent and cellulose tris(4-chloro-3-methylphenylcarbamate) coated on silica as chiral stationary phase was successfully developed and applied for the enantiomeric purity determination of S-ropivacaine in a pharmaceutical formulation (Naropin((R))). The key role played by the acidic additive (trifluoroacetic acid or formic acid) in the enantioseparation of basic drugs in these LC systems was demonstrated by the reversal of ropivacaine enantiomers elution order observed when both acids were compared. In order to elute the enantiomeric impurity (R-ropivacaine) before S-ropivacaine, formic acid (FA) was selected. The temperature and the percentages of acidic additive and hexane in the mobile phase were found to significantly influence the retention and resolution of these enantiomers. The optimized mobile phase consisted of ACN/0.1% DEA/0.2% FA/5% hexane (v/v/v/v). The temperature was set at 35 degrees C to avoid the interference from a peak system related to the presence of water in the sample on ropivacaine enantiomers. The LC method was then fully validated applying the strategy based on total measurement error and accuracy profiles. The accuracy profile obtained by linear regression after square root transformation was selected, the acceptance limits being settled at +/-10% for the intended use of this analytical method. The relative bias was lower than 1.5%, while the RSD values for repeatability and intermediate precision were both below 1.0%. The limit of detection (LOD) and the limit of quantification (LOQ) were found to be about 0.2 and 1.0 mug/mL, respectively, corresponding to 0.02 and 0.1% of the enantiomeric impurity in S-ropivacaine. [less ▲]

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See detailInventaire des archives de la Société Cockerill Sambre (Groupe Arcelor). Siège de Seraing (1806-2005)
Delvaux, Anne-Catherine ULg

Book published by Archives générales du Royaume (2011)

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See detailRapid regulation by glutamate of aromatase activity
Charlier, Thierry ULg; Ball, Gregory; Balthazart, Jacques ULg

Poster (2011)

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See detailThe use of micro-CT to correlate in-vitro cell behaviour with the surface roughness of Ti6Al4V scaffolds for tissue engineering
Pyka, Grzegorz; Kerckhofs, Greet ULg; Chai, Yoke Chin et al

in Abstract book SkyScan User Meeting 2011 (2011)

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See detailA computational solid and fluid mechanical analysis of CAD-versus micro-CT-based models of regular Ti6Al4V scaffolds for bone tissue engineering
Truscello, Silvia; Kerckhofs, Greet ULg; Moesen, Maarten et al

in Histology and Histopathology (2011)

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See detailSonia Hajjar Domaine : Human resource management Titre : Status of Female Auditors in Lebanon: Careers and Family Concerns
Hajjar, Sonia ULg

Doctoral thesis (2011)

This research discusses the status of female auditors in Lebanon with a special emphasis on individual career and family concerns. It attempts at investigating the status of female auditors, and at ... [more ▼]

This research discusses the status of female auditors in Lebanon with a special emphasis on individual career and family concerns. It attempts at investigating the status of female auditors, and at pointing out the major hindrances that they face when trying to achieve a balance between career and family life; thus, issues such as organizational, individual, and social factors are discussed. The focus is to discuss the status of female Lebanese auditors through analysis and conclusions drawn from practical experience and to present a model of the issues in relation to certain variables and factors. Questionnaires and interviews were used to collect the data. Results show that the above-mentioned factors, cross-referenced with the glass ceiling, work life balance, and turnover, are combined. Research revealed that many factors mold the status of female auditors in Lebanon. The limitations of the study stem from the fact that no such studies have been conducted in Lebanon and, thus, the literature review was mainly constructed on published research done in the West. Results reveal that the individual Lebanese female auditor is faced with a glass ceiling only because she chose her family over her career, and when she chose to leave the profession (turnover) it was because of her family duties, the long working hours, stress, and work life balance that forced her to make a choice between herself as a career women, or as a mother and wife. The study is aimed at establishing possible relationship between academia, audit profession, and the business market. [less ▲]

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See detailLe droit de la construction
Kohl, Benoît ULg

Book published by Anthemis (2011)

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See detailPreliminary experience of a modified Maquet technique for repair of cranial cruciate ligament rupture in dogs
Etchepareborde, Sébastien; Brunel, Laurencie ULg; Bolen, Géraldine ULg et al

in Veterinary and Comparative Orthopaedics and Traumatology (2011)

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See detailFluorescent microparticle incorporation in chondrogenic cell aggregates to monitor local oxygen tension
Lambrechts, Dennis; Kerckhofs, Greet ULg; Roberts, Scott et al

in Histology and Histopathology (2011)

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See detailTransient Fokker-Planck Equation solved with SPH
Canor, Thomas ULg; Denoël, Vincent ULg

in Proceedings of the 5th International Conference on Advanced Computational Methods in Engineering (2011)

In many engineering matters, systems are submitted to random excitations. Probabilistic theories aim at describing the properties of a system by means of statistical properties such as probability density ... [more ▼]

In many engineering matters, systems are submitted to random excitations. Probabilistic theories aim at describing the properties of a system by means of statistical properties such as probability density function (pdf). For a deterministic system randomly excited, the evolution of its pdf is commonly described with Fokker-Planck-Kolmogorov equation (FPK). The FPK equation is a conservation equation of a hypothetical fluid, which represents physically the transport of probability. To solve this equation, Smoothed Particle Hydrodynamics (SPH) are used: the system is modelled with a conservation equation for the system and a transport equation for each particle. Numerical implementation shows the superiority of this method over many other mesh-based methods: (i) the conservation of total probability in the state space is explicitly written, (ii) no specific boundary conditions must be imposed if an adaptive smoothing length is chosen and if particles are initially regularly spread out, (iii) the positivity of the pdf is ensured. Furthermore, thanks to the moving particles, this method is adapted for a large kind of initial conditions (quasi-deterministic or even discontinuous). The FPK equation can be solved without any a priori knowledge of the stationary distribution; just a precise representation of the initial distribution is required. [less ▲]

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