References of "2011"
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See detailCompte rendu de C. Calame, Prométhée généticien, Paris, 2010
Delli Pizzi, Aurian ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (2011), 24

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See detailInventaire des archives de la Société anonyme d'Ougrée-Marihaye (1835-1955)
Delvaux, Anne-Catherine ULg

Book published by Archives générales du Royaume (2011)

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See detailMalignant catarrhal fever induced by Alcelaphine herpesvirus 1 is characterized by an expansion of activated CD3+CD8+CD4- T cells expressing a cytotoxic phenotype in both lymphoid and non-lymphoid tissues.
Dewals, Benjamin G ULg; Vanderplasschen, Alain ULg

in Veterinary research (2011), 42(1), 95

ABSTRACT: Alcelaphine herpesvirus 1 (AlHV-1) is carried by wildebeest asymptomatically. It causes a fatal lymphoproliferative disease named wildebeest-derived malignant catarrhal fever (WD-MCF) when cross ... [more ▼]

ABSTRACT: Alcelaphine herpesvirus 1 (AlHV-1) is carried by wildebeest asymptomatically. It causes a fatal lymphoproliferative disease named wildebeest-derived malignant catarrhal fever (WD-MCF) when cross-species transmitted to a variety of susceptible species of the Artiodactyla order. WD-MCF can be reproduced experimentally in rabbits. In a previous report, we demonstrated that WD-MCF induced by AlHV-1 is associated with a severe proliferation of CD8+ T cells in the lymphoid tissues. Here, we further studied the mononuclear leukocytic populations in both the lymphoid (throughout the infection and at time of euthanasia) and non-lymphoid (at time of euthanasia) organs during WD-MCF induced experimentally in rabbits. To reach that goal, we performed multi-colour flow cytometry stainings. The results obtained demonstrate that the development of WD-MCF correlates in peripheral blood with a severe increase of CD8+ cell percentages; and that CD3+CD8+CD4- T cells were the predominant cell type in both lymphoid and non-lymphoid organs at time of euthanasia. Further characterization of the mononuclear leukocytes isolated from both lymphoid and non-lymphoid tissues revealed that the CD8+ T cells express high levels of the activation markers CD25 and CD44, produce high amount of gamma-interferon (IFN-gamma) and perforin, and showed a reduction of interleukin-2 (IL-2) gene expression. These data demonstrate that the development of WD-MCF is associated with the expansion and infiltration of activated and cytotoxic CD3+CD8+CD4- T cells secreting high amount of IFN-gamma but low IL-2. [less ▲]

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See detailWeed detection in 3D images
Piron, Alexis ULg; Van Der Heijden, F.; Destain, Marie-France ULg

in Precision Agriculture (2011), 12(5), 607-622

Machine vision has been successfully used for mechanical destruction of weeds between rows of crops. Knowledge of the position of the rows where crops should be growing and the assumption that plants ... [more ▼]

Machine vision has been successfully used for mechanical destruction of weeds between rows of crops. Knowledge of the position of the rows where crops should be growing and the assumption that plants growing outside such positions are weeds may be used in such systems. However for many horticultural crops, the automatic removal of weeds from inside a row or bands of crops in which the weeds are mixed with plants in a random manner is not solved. The aim of this study was to verify that plant height is a discriminating parameter between crop and weed at early growth stages, as weeds and crops grow at different speeds. Plant height was determined by using an active stereoscopy technique, based on a time multiplexing coded structured light developed to take into account the specificities of the small scale scene, namely occlusion and thin objects, internal reflections and high dynamic range. The study was conducted on two carrot varieties sown at commercial density. Different weed species were present at the time of data acquisition. To accurately represent plant height taking into account the ground irregularities, a new parameter called ‘corrected plant height’ was computed. This parameter was the distance between plant pixels and the actual ground level under them obtained by fitting a surface and seen from a reconstructed point of view corresponding to a camera’s optical axis perpendicular to the ridge plane. The overall classification accuracy without correction was 66% whereas it reached 83% by using the corrected plant height. [less ▲]

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See detailSequencing of DISC1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern Swedish population.
Moens, Lotte N.; De Rijk, Peter; Reumers, Joke et al

in PloS one (2011), 6(8), 23450

In recent years, DISC1 has emerged as one of the most credible and best supported candidate genes for schizophrenia and related neuropsychiatric disorders. Furthermore, increasing evidence--both genetic ... [more ▼]

In recent years, DISC1 has emerged as one of the most credible and best supported candidate genes for schizophrenia and related neuropsychiatric disorders. Furthermore, increasing evidence--both genetic and functional--indicates that many of its protein interaction partners are also involved in the development of these diseases. In this study, we applied a pooled sample 454 sequencing strategy, to explore the contribution of genetic variation in DISC1 and 10 of its interaction partners (ATF5, Grb2, FEZ1, LIS-1, PDE4B, NDE1, NDEL1, TRAF3IP1, YWHAE, and ZNF365) to schizophrenia susceptibility in an isolated northern Swedish population. Mutation burden analysis of the identified variants in a population of 486 SZ patients and 514 control individuals, revealed that non-synonymous rare variants with a MAF<0.01 were significantly more present in patients compared to controls (8.64% versus 4.7%, P = 0.018), providing further evidence for the involvement of DISC1 and some of its interaction partners in psychiatric disorders. This increased burden of rare missense variants was even more striking in a subgroup of early onset patients (12.9% versus 4.7%, P = 0.0004), highlighting the importance of studying subgroups of patients and identifying endophenotypes. Upon investigation of the potential functional effects associated with the identified missense variants, we found that approximately 90% of these variants reside in intrinsically disordered protein regions. The observed increase in mutation burden in patients provides further support for the role of the DISC1 pathway in schizophrenia. Furthermore, this study presents the first evidence supporting the involvement of mutations within intrinsically disordered protein regions in the pathogenesis of psychiatric disorders. As many important biological functions depend directly on the disordered state, alteration of this disorder in key pathways may represent an intriguing new disease mechanism for schizophrenia and related neuropsychiatric diseases. Further research into this unexplored domain will be required to elucidate the role of the identified variants in schizophrenia etiology. [less ▲]

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See detailBeyond matching on the mean in developmental disabilities research
Facon, Bruno; Magis, David ULg; Belmont, John M

in Research in Developmental Disabilities (2011), 32

The matching of groups is a traditional way to control for confounding variables in developmental disability research. The equivalency of means across groups is routinely checked for these variables, but ... [more ▼]

The matching of groups is a traditional way to control for confounding variables in developmental disability research. The equivalency of means across groups is routinely checked for these variables, but not the homogeneity of their variances or the shapes of their distributions. In the present paper, it is argued that group matching can go seriously wrong unless it directly confronts the distributional concerns by the use of well-known statistical indices and very simple graphical displays of the distributions. The question of the equivalency of item response profiles is also addressed since two participants or two groups of participants can obtain the same overall score on the matching variable by passing different items. In this case, the matching cannot be considered satisfactory because of poor concordance between the molar (overall score) and molecular (item scores) levels of matching. Angoff's Delta plot method, a statistical approach for detecting differential item functioning across small groups is described. It is promising as a simple way to prove whole test/individual item correspondence and, in addition, a useful tool for making post-hoc statistical analyses at the item level on the dependant variables. [less ▲]

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See detailModélisation numérique de l'expérience SDZ pour l'Andra
Pardoen, Benoît ULg; Charlier, Robert ULg; Radu, Jean-Pol ULg

Report (2011)

An in situ ventilation test (SDZ) is performed by the French national radioactive waste management agency (ANDRA) in the Meuse/Haute-Marne underground research laboratory. The aim is to characterise the ... [more ▼]

An in situ ventilation test (SDZ) is performed by the French national radioactive waste management agency (ANDRA) in the Meuse/Haute-Marne underground research laboratory. The aim is to characterise the effect of the desaturation and possible resaturation of the damaged zone located around an experimental gallery due to controlled ventilation imposed in this gallery. Hydro and hydro-mechanical numerical modellings are realised in order to acquire a better understanding of clayey rock behaviour and transfers occurring during the test. [less ▲]

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See detailArsenic-doped Ge-spiked monoemitter SiGe:C HBTs by means of low-temperature trisilane based epitaxy
You, Shuzhen; Decoutere, Stefaan; Nguyen, Ngoc Duy ULg et al

Conference (2011)

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See detailRate of Malignancies and Infections in a Large Single Center Cohort of IBD Patients Treated With Thiopurines and Anti-TNF-Antibodies.
Ochsenkühn, T; Steinborn, A; Beigel, F et al

in Journal of Crohn’s and Colitis (2011)

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See detailIntroduction sur la croissance
Kaux, Jean-François ULg

Learning material (2011)

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See detailEffective Production of the Biodiesel Additive STBE by a Continuous Flow Process
Monbaliu, Jean-Christophe ULg; Winter, Marc; Chevalier, Bérengère et al

in Bioresource Technology (2011), 102

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See detailInventaire des archives de la Compagnie générale des Conduites d'Eau (1865-1965)
Delvaux, Anne-Catherine ULg

Book published by Archives générales du Royaume (2011)

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See detailModeling post-combustion CO2 capture with amine solvents
Léonard, Grégoire ULg; Heyen, Georges ULg

in Computer Aided Chemical Engineering (2011), 29

Carbon capture and storage is a technology that can contribute to face the challenge of rising energy demand combined with a growing environmental awareness. In the present work, the CO2 capture process ... [more ▼]

Carbon capture and storage is a technology that can contribute to face the challenge of rising energy demand combined with a growing environmental awareness. In the present work, the CO2 capture process with monoethanolamine (MEA) is modeled using the simulation tool Aspen Plus. Two different modeling approaches are studied and compared: the equilibrium and the rate-based approaches. An optimization of key process parameters is performed and process modifications are studied with the objective of improving the global process energy efficiency. [less ▲]

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See detailPredictive modelling of the combined effect of temperature and water activity (aw) on the in vitro growth of Erwinia spp infecting potato tubers in Belgium
Moh, Augustin; Massart, Sébastien ULg; Lahlali, Rachid et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2011), 15(3), 378-386

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See detailRapid regulation by glutamate of aromatase activity
Charlier, Thierry ULg; Ball, Gregory; Balthazart, Jacques ULg

Poster (2011)

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See detailA non-invasive approach to study lifetime exposure and bioaccumulation of PCBs in protected marine mammals: PBPK modeling in harbor porpoises
Weijs, Liesbeth; Covaci, Adrian; Yang, Raymond S. H. et al

in Toxicology and Applied Pharmacology (2011), 256

In the last decade, physiologically based pharmacokinetic (PBPK) models have increasingly been developed to explain the kinetics of environmental pollutants in wildlife. For marine mammals specifically ... [more ▼]

In the last decade, physiologically based pharmacokinetic (PBPK) models have increasingly been developed to explain the kinetics of environmental pollutants in wildlife. For marine mammals specifically, these models provide a new, non-destructive tool that enables the integration of biomonitoring activities and in vitro studies. The goals of the present study were firstly to develop PBPK models for several environmental relevant PCB congeners in harbor porpoises (Phocoena phocoena), a species that is sensitive to pollution because of its limited metabolic capacity for pollutant transformation. These models were tested using tissue data of porpoises from the Black Sea. Secondly, the predictive power of the models was investigated for time trends in the PCB concentrations in North Sea harbor porpoises between 1990 and 2008. Thirdly, attempts were made to assess metabolic capacities of harbor porpoises for the investigated PCBs. In general, results show that parameter values from other species (rodents, humans) are not always suitable in marine mammal models, most probably due to differences in physiology and exposure. The PCB 149 levels decrease the fastest in male harbor porpoises from the North Sea in a time period of 18†years, whereas the PCB 101 levels decrease the slowest. According to the models, metabolic breakdown of PCB 118 is probably of lesser importance compared to other elimination pathways. For PCB 101 and 149 however, the presence of their metabolites can be attributed to bioaccumulation of metabolites from the prey and to metabolic breakdown of the parent compounds in the harbor porpoises. [less ▲]

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See detailEuler
Dupont, Pascal ULg

in Courtois, Luc; Pirotte, Jean (Eds.) Mémoires de Wallonie : Les rues de Louvain-la-Neuve racontent... (2011)

Biographical notice of Leonhard Euler.

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See detailGenou douloureux de l'enfant sportif
Kaux, Jean-François ULg

Learning material (2011)

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