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See detailInvestigating Hardy-Weinberg equilibrium in case-control or cohort studies or meta-analysis.
Ziegler, Andreas; Van Steen, Kristel ULg; Wellek, Stefan

in Breast Cancer Research and Treatment (2011), 128(1), 197-201

Yu et al. (Breast Cancer Res Treat 117:675-677, 2009) recently stated that testing for deviation from Hardy-Weinberg equilibrium (HWE) is necessary to identify systematic genotyping errors in case-control ... [more ▼]

Yu et al. (Breast Cancer Res Treat 117:675-677, 2009) recently stated that testing for deviation from Hardy-Weinberg equilibrium (HWE) is necessary to identify systematic genotyping errors in case-control studies. They criticized a meta-analytic study for the deviation from HWE in the case group of one study. The aim of this article is twofold. First, we derive recommendations on how to test for deviations from HWE in different study designs. Second, we develop a meta-analytic framework for assessing compatibility with HWE or measuring deviation from HWE. The authors sketch the possible reasons behind deviation from HWE and provide guidelines for proper investigation of HWE deviations in different study designs. The authors argue that the standard HWE chi(2) lack of fit test is logically flawed and provide a logically unflawed approach for measuring deviation from HWE using confidence intervals. The proposed method is applicable to meta-analyses of both case-control or cohort association studies. The proposed approach is illustrated using the meta-analysis criticized by Yu et al. Heterogeneity between studies can be assessed. The critique of Yu et al. to the article of Frank et al. (Breast Cancer Res Treat 111:139-144, 2008) can be refuted. Even more, validity of HWE can be proven for the pooled control sample. The authors advocate the use of a confidence interval-based approach to assess HWE. The latter should only be investigated in control populations. In multicenter studies or meta-analysis, deviation from HWE should be analyzed using a meta-analytic approach. [less ▲]

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See detailConservation of endangered plant communities: a study case of ecosystem reconstruction in Katanga (DRC)
Lebrun, Julie ULg; Handjila, Guylain; Bizoux, Jean-Philippe ULg et al

Conference (2011)

The Katangan copper-cobalt deposits (Democratic Republic of Congo) are part of the Central African Copperbelt, one of the world’s greatest metallogenic province. The ore comes to the surface in a series ... [more ▼]

The Katangan copper-cobalt deposits (Democratic Republic of Congo) are part of the Central African Copperbelt, one of the world’s greatest metallogenic province. The ore comes to the surface in a series of hills isolated in the miombo woodland. These unique ecosystems present high metals concentration levels where a specific vegetation develops. Flora comprises more than 600 species from which 30 are endemics. Due to the recent revival of mining activities in the region, copper plant communities of Katanga and their associated flora are now critically threatened. Tenke Fungurume Mining sarl (TFM), an important mining company operating in Katanga, has developed a Biological Diversity Action Plan (BDAP) to conserve copper-cobalt flora and mitigate potential species extinction risk. One of the most original BDAP tasks is an ecosystem reconstruction experiment that should preserve plant communities representative of the diversity found on the exploited hill and to provide the plant material for further post-exploitation restoration. From December 2007 to April 2009, full vegetation blocks were translocated with their soil mat on an adequate mineral substrate of 1500m². Since 2008, the artificial ecosystem is monitored every year. Three communities were successfully recreated. A total of 144 species were found in the ecosystem which represents more than 80% of the original species richness. The reconstructed ecosystem seems to favour the most tolerant species to copper. This first experience shows that ecosystem reconstruction is successful and may be used as a strategy to conserve copper-cobalt plant communities in their habitat. [less ▲]

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See detailCaractérisation des pigments préhistoriques par analyse PIXE
Lebon, Matthieu; Beck, Lucile; Lahlil, Sophia et al

Poster (2011)

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See detail1997–2007 CO trend at the high Alpine site Jungfraujoch: a comparison between NDIR surface in situ and FTIR remote sensing observations
Dils, B.; Cui, J.; Henne, S. et al

in Atmospheric Chemistry and Physics (2011), 11(13), 6735--6748

Within the atmospheric research community, there is a strong interest in integrated datasets, combining data from several instrumentations. This integration is complicated by the different characteristics ... [more ▼]

Within the atmospheric research community, there is a strong interest in integrated datasets, combining data from several instrumentations. This integration is complicated by the different characteristics of the datasets, inherent to the measurement techniques. Here we have compared two carbon monoxide time series (1997 till 2007) acquired at the high-Alpine research station Jungfraujoch (3580 m above sea level), with two well-established measurement techniques, namely in situ surface concentration measurements using Non-Dispersive Infrared Absorption technology (NDIR), and ground-based remote sensing measurements using solar absorption Fourier Transform Infrared spectrometry (FTIR). The profile information available in the FTIR signal allowed us to extract an independent layer with a top height of 7.18 km above sea level, appropriate for comparison with our in situ measurements. We show that, even if both techniques are able to measure free troposphere CO concentrations, the datasets exhibit marked differences in their overall trends (−3.21 ± 0.03 ppb/year for NDIR vs. −0.8 ± 0.4 ppb/year for FTIR). Removing measurements that are polluted by uprising boundary layer air has a strong impact on the NDIR trend (now −2.62 ± 0.03 ppb/year), but its difference with FTIR remains significant. Using the LAGRANTO trajectory model, we show that both measurement techniques are influenced by different source regions and therefore are likely subject to exhibit significant differences in their overall trend behaviour. However the observation that the NDIR-FTIR trend difference is as significant before as after 2001 is at odds with available emission databases which claim a significant Asian CO increase after 2001 only. [less ▲]

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See detailToxicologie clinique et médico-légale
Renaux, André; Renaux - Muylkens, Isabelle; Charlier, Corinne ULg et al

in Beauthier, Jean-Pol (Ed.) Traité de Médecine légale (2011)

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See detailA finite element analysis of the bending and the bendability of metallic sheets
Ben Bettaieb, Mohamed ULg; Lemoine, Xavier; Bouaziz, O. et al

in International Journal of Material Forming (2011), 4(3), 283-297

The main objective of this paper is to study the bendability of metallic sheets by using the finite element method. In this aim, two variants of an advanced Gurson-Tvergaard-Needleman model [1, 2] are ... [more ▼]

The main objective of this paper is to study the bendability of metallic sheets by using the finite element method. In this aim, two variants of an advanced Gurson-Tvergaard-Needleman model [1, 2] are implemented in the home made FE code LAGAMINE [3, 4] and coupled with the Thomason model to predict the coalescence of voids. This advanced model is an extension of the original one to take into account of the plastic anisotropy and the mixed (isotropic + kinematic) hardening of the matrix. The difference between the two variants is related to the modeling of the damage evolution. As the advanced model is used to study the bending process, its yield function is slightly modified in order to take into account the loadings with negative triaxiality ratios. These present implementations are used to simulate the pure bending process and to predict the bendability of dual phase (DP) steel. The combined effect of an initial geometrical imperfection and damage evolution on the bendability is also studied. [less ▲]

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See detailGreek Cults of Aphrodite
Pirenne-Delforge, Vinciane ULg; Pironti, Gabriella

in Kondoleon, Christine; Segal, Phoebe (Eds.) Aphrodite and the Gods of Love (2011)

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See detailBouncing bubble on a liquid/gas interface resting or vibrating
Zawala, jan; Dorbolo, Stéphane ULg; Terwagne, Denis ULg et al

in Soft Matter (2011)

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See detailSystèmes de positionnement par satellites
Warnant, René ULg

Learning material (2011)

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See detailA Chandra search for low-mass companions of late B-stars in Tr16
Evans, N. R.; DeGioia-Eastwood, K.; Gagné, M. et al

Poster (2011)

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See detailCompte rendu de l'ouvrage d'Alexia PETSALIS-DIOMIDIS, А. Truly Beyond Wonders: Aelius Aristides and the Cult of Asklepios
Rochette, Bruno ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (2011), 24

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See detailPathophysiology and prevention of postoperative peritoneal adhesions.
Arung, Willy; Meurisse, Michel ULg; DETRY, Olivier ULg

in World Journal of Gastroenterology (2011), 17(41), 4545-53

Peritoneal adhesions represent an important clinical challenge in gastrointestinal surgery. Peritoneal adhesions are a consequence of peritoneal irritation by infection or surgical trauma, and may be ... [more ▼]

Peritoneal adhesions represent an important clinical challenge in gastrointestinal surgery. Peritoneal adhesions are a consequence of peritoneal irritation by infection or surgical trauma, and may be considered as the pathological part of healing following any peritoneal injury, particularly due to abdominal surgery. The balance between fibrin deposition and degradation is critical in determining normal peritoneal healing or adhesion formation. Postoperative peritoneal adhesions are a major cause of morbidity resulting in multiple complications, many of which may manifest several years after the initial surgical procedure. In addition to acute small bowel obstruction, peritoneal adhesions may cause pelvic or abdominal pain, and infertility. In this paper, the authors reviewed the epidemiology, pathogenesis and various prevention strategies of adhesion formation, using Medline and PubMed search. Several preventive agents against postoperative peritoneal adhesions have been investigated. Their role aims in activating fibrinolysis, hampering coagulation, diminishing the inflammatory response, inhibiting collagen synthesis or creating a barrier between adjacent wound surfaces. Their results are encouraging but most of them are contradictory and achieved mostly in animal model. Until additional findings from future clinical researches, only a meticulous surgery can be recommended to reduce unnecessary morbidity and mortality rates from these untoward effects of surgery. In the current state of knowledge, pre-clinical or clinical studies are still necessary to evaluate the effectiveness of the several proposed prevention strategies of postoperative peritoneal adhesions. [less ▲]

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See detailEvolution of livelihood strategy and income of the households in the coastal sandy area of the Central region, Vietnam : the case of Thua Thien Hue Province during period 2003-2008
Nguyen Dang, Hao; Lebailly, Philippe ULg

Conference (2011)

Based on livelihood approach and using both livelihood strategy participatory assessment and household survey data this study mainly focus on assessment of evolution of livelihood strategy and income of ... [more ▼]

Based on livelihood approach and using both livelihood strategy participatory assessment and household survey data this study mainly focus on assessment of evolution of livelihood strategy and income of households in the Coastal Sandy Zone of Thua Thien Hue Province. Findings indicated that livelihood strategies are very dynamic and considerable difference between the wealth categories of households and among the study sites. Although agriculture –based strategy is one of the most popular among the livelihood strategies there are considerable changes. Thanks to more specialization on livestock - non-farm business – aquaculture the better-off category has increased rapidly their income during 2003-2008 period. By contrast, due to more dependence on food crop, wage work and migration, income of the poor slowly improved at the same period. These findings implicate that in the context of rural development, support policies introduced by government have positively influenced on household income, but these general policies cannot meet the development needs from various locations as well as different household categories because there is marked difference in livelihood assets, human source, landholding, financial and social capitals in particular. [less ▲]

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See detailIdentification d'une dermatose provoquée par la lumière
PIERARD-FRANCHIMONT, Claudine ULg; CAUCANAS, Marie ULg; QUATRESOOZ, Pascale ULg et al

in Revue Médicale de Liège (2011), 66

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See detailThe influence of encoding style on the production of false memories in the DRM paradigm: New insights on individual differences in false memory susceptibility?
Dehon, Hedwige ULg; Laroi, Frank ULg; Van der Linden, Martial ULg

in Personality & Individual Differences (2011), 50(5), 583-587

Recent research has shown that there are individual differences in how preexisting (internal) schemata (versus cues from the outside world) affect encoding processes, which can be reliably assessed with ... [more ▼]

Recent research has shown that there are individual differences in how preexisting (internal) schemata (versus cues from the outside world) affect encoding processes, which can be reliably assessed with the internal and external Encoding Style Questionnaire (ESQ, Lewicki, 2005). Since reliance on preexisting schemata at encoding has been found to increase the production of false memories in the DRM paradigm (Roediger & McDermott, 1995), while item-specific encoding has been shown to reduce it (see Gallo, 2006), it was examined whether individual differences in encoding style affects the production of such false memories. To this purpose, normal participants were asked to complete a French version of the ESQ questionnaire (Billieux et al., 2009) and were presented with a modified DRM procedure (Brédart, 2000) assessing false recall. The results showed a positive correlation between ESQ scores and false recall showing that internal encoders were more susceptible to false memories than external encoders. [less ▲]

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See detailSmall molecule inhibitors of peptidoglycan synthesis targeting the lipid II precursor.
Derouaux, Adeline ULg; Turk, Samo; Olrichs, Nick K et al

in Biochemical Pharmacology (2011), 81(9), 1098-105

Bacterial peptidoglycan glycosyltransferases (GTs) of family 51 catalyze the polymerization of the lipid II precursor into linear peptidoglycan strands. This activity is essential to bacteria and ... [more ▼]

Bacterial peptidoglycan glycosyltransferases (GTs) of family 51 catalyze the polymerization of the lipid II precursor into linear peptidoglycan strands. This activity is essential to bacteria and represents a validated target for the development of new antibacterials. Application of structure-based virtual screening to the National Cancer Institute library using eHits program and the structure of the glycosyltransferase domain of the Staphylococcus aureus penicillin-binding protein 2 resulted in the identification of two small molecules analogues 5, a 2-[1-[(2-chlorophenyl)methyl]-2-methyl-5-methylsulfanylindol-3-yl]ethanamine and 5b, a 2-[1-[(3,4-dichlorophenyl)methyl]-2-methyl-5-methylsulfanylindol-3-yl]ethanamine that exhibit antibacterial activity against several Gram-positive bacteria but were less active on Gram-negative bacteria. The two compounds inhibit the activity of five GTs in the micromolar range. Investigation of the mechanism of action shows that the compounds specifically target peptidoglycan synthesis. Unexpectedly, despite the fact that the compounds were predicted to bind to the GT active site, compound 5b was found to interact with the lipid II substrate via the pyrophosphate motif. In addition, this compound showed a negatively charged phospholipid-dependent membrane depolarization and disruption activity. These small molecules are promising leads for the development of more active and specific compounds to target the essential GT step in cell wall synthesis. [less ▲]

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See detailIl ruolo del “magico numero sette” nella canzone d’autore italiana
Valenti, Gianluca ULg

in Cognitive Philology (2011), 4

Con il presente articolo si vogliono indagare le possibili correlazioni fra la regola milleriana del “Magical Number Seven” e le modalità di produzione e fruizione della canzone d’autore italiana. I dati ... [more ▼]

Con il presente articolo si vogliono indagare le possibili correlazioni fra la regola milleriana del “Magical Number Seven” e le modalità di produzione e fruizione della canzone d’autore italiana. I dati qui presentati (in accordo con la legge di Miller) permettono di verificare che, in assenza di vincoli metrici autoimposti, le canzoni d’autore mostrano una generalizzata (e dunque cognitiva?) tendenza ad organizzare le sillabe, i versi e le strofe in gruppi delimitati, composti approssimativamente da sette più o meno due elementi. [less ▲]

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See detailNom d’auteur et énonciateur dans divers écrits de Voltaire sur les affaires Calas, Sirven et la Barre
Tilkin, Françoise ULg

in Renwick, John (Ed.) Voltaire, la tolérance et la justice (2011)

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See detailInfluence of anesthesia on cerebral blood flow, cerebral metabolic rate, and brain functional connectivity.
BONHOMME, Vincent ULg; BOVEROUX, Pierre ULg; HANS, Pol ULg et al

in Current Opinion in Anaesthesiology (2011), 24(5), 474-9

PURPOSE OF REVIEW: To describe recent studies exploring brain function under the influence of hypnotic anesthetic agents, and their implications on the understanding of consciousness physiology and ... [more ▼]

PURPOSE OF REVIEW: To describe recent studies exploring brain function under the influence of hypnotic anesthetic agents, and their implications on the understanding of consciousness physiology and anesthesia-induced alteration of consciousness. RECENT FINDINGS: Cerebral cortex is the primary target of the hypnotic effect of anesthetic agents, and higher-order association areas are more sensitive to this effect than lower-order processing regions. Increasing concentration of anesthetic agents progressively attenuates connectivity in the consciousness networks, while connectivity in lower-order sensory and motor networks is preserved. Alteration of thalamic sub-cortical regulation could compromise the cortical integration of information despite preserved thalamic activation by external stimuli. At concentrations producing unresponsiveness, the activity of consciousness networks becomes anticorrelated with thalamic activity, while connectivity in lower-order sensory networks persists, although with cross-modal interaction alterations. SUMMARY: Accumulating evidence suggests that hypnotic anesthetic agents disrupt large-scale cerebral connectivity. This would result in an inability of the brain to generate and integrate information, while external sensory information is still processed at a lower order of complexity. [less ▲]

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