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See detailEFFECTS OF SUBLIMINAL PRIMING ON NONCONSCIOUS GOAL PURSUIT AND EFFORT-RELATED CARDIOVASCULAR RESPONSE
Capa, Rémi ULg; Cleeremans, Axel; Bustin, Gaëlle ULg et al

in Social Cognition (2011), 29(4), 430-444

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See detailStudy of six models of the instantaneous pressure-volume relationship
Lucas, Alexandra ULg; Dauby, Pierre ULg; Desaive, Thomas ULg et al

in Proceedings of the XXIIIth Congress of the ISB (2011)

Models and simulations are very useful to study interactions between anatomic structures and physical cardiac phenomena. In this work, we are interested in models of the instantaneous pressure-volume ... [more ▼]

Models and simulations are very useful to study interactions between anatomic structures and physical cardiac phenomena. In this work, we are interested in models of the instantaneous pressure-volume relationship, i.e. isochrone models. More precisely, we concentrate on the 6 models considered by Lankhaar et al. [1]. We propose a critical analysis of the work of these authors and suggest some improvement of their procedure. [1] Lankhaar J.-W. et al. Modeling the Instantaneous Pressure–Volume Relation of the Left Ventricle: A Comparison of Six Models. Annals of Biomedical Engineering, Volume 37, Number 9, 1710-1726, 2009. [less ▲]

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See detailIntroduction au droit privé
Gerkens, Jean-François ULg

Learning material (2011)

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See detailOn the Origin of Model Relations among Transverse-Momentum Dependent Parton Distributions
Lorce, Cédric ULg; Pasquini, B.

in Physical Review. D, Particles, Fields, Gravitation, and Cosmology (2011), D84

Transverse-momentum dependent parton distributions (TMDs) are studied in the framework of quark models. In particular, quark-model relations among TMDs are reviewed, elucidating their physical origin in ... [more ▼]

Transverse-momentum dependent parton distributions (TMDs) are studied in the framework of quark models. In particular, quark-model relations among TMDs are reviewed, elucidating their physical origin in terms of the quark-spin structure in the nucleon. The formal aspects of the derivation of these relations are complemented with explicit examples, emphasizing how and to which extent the conditions which lead to relations among TMDs are implemented in different classes of quark models. [less ▲]

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See detailNew insights on the role of root radial conductivity on the overall uptake dynamics
Lobet, Guillaume ULg; Javaux, M.; Couvreur, V. et al

Conference (2011)

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See detailLa mobilité étudiante au prisme du discours spontané: les représentations de la langue française
Meunier, Deborah ULg

in Esteve, I (Ed.) Autour des langues et du langage - perspective pluridisciplinaire (2011)

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See detailInventaire des archives du Comité de Secours et d'Alimentation de la Province de Liège (1914-1922)
Delvaux, Anne-Catherine ULg

Book published by Archives générales du Royaume (2011)

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See detailAtouts, faiblesses et défis futurs de la filière lait et produits laitiers en Belgique
Burny, Philippe ULg

in Centre wallon de Recherches agronomiques (Ed.) Seizième Carrefour des Productions Animales "La Filière laitière bovine européenne est-elle durable ?" (2011)

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See detailAnalysis of positional candidate genes in the AAA1 susceptibility locus for abdominal aortic aneurysms on chromosome 19.
Lillvis, J. H.; Kyo, Y.; Tromp, G. et al

in BMC Medical Genetics (2011), 12(1), 14

ABSTRACT: BACKGROUND: Abdominal aortic aneurysm (AAA) is a complex disorder with multiple genetic risk factors. Using affected relative pair linkage analysis, we previously identified an AAA ... [more ▼]

ABSTRACT: BACKGROUND: Abdominal aortic aneurysm (AAA) is a complex disorder with multiple genetic risk factors. Using affected relative pair linkage analysis, we previously identified an AAA susceptibility locus on chromosome 19q13. This locus has been designated as the AAA1 susceptibility locus in the Online Mendelian Inheritance in Man (OMIM) database. METHODS: Nine candidate genes were selected from the AAA1 locus based on their function, as well as mRNA expression levels in the aorta. A sample of 394 cases and 419 controls was genotyped for 41 SNPs located in or around the selected nine candidate genes using the Illumina GoldenGate platform. Single marker and haplotype analyses were performed. Three genes (CEBPG, PEPD and CD22) were selected for DNA sequencing based on the association study results, and exonic regions were analyzed. Immunohistochemical staining of aortic tissue sections from AAA and control individuals was carried out for the CD22 and PEPD proteins with specific antibodies. RESULTS: Several SNPs were nominally associated with AAA (p < 0.05). The SNPs with most significant p-values were located near the CCAAT enhancer binding protein (CEBPG), peptidase D (PEPD), and CD22. Haplotype analysis found a nominally associated 5-SNP haplotype in the CEBPG/PEPD locus, as well as a nominally associated 2-SNP haplotype in the CD22 locus. DNA sequencing of the coding regions revealed no variation in CEBPG. Seven sequence variants were identified in PEPD, including three not present in the NCBI SNP (dbSNP) database. Sequencing of all 14 exons of CD22 identified 20 sequence variants, five of which were in the coding region and six were in the 3'-untranslated region. Five variants were not present in dbSNP. Immunohistochemical staining for CD22 revealed protein expression in lymphocytes present in the aneurysmal aortic wall only and no detectable expression in control aorta. PEPD protein was expressed in fibroblasts and myofibroblasts in the media-adventitia border in both aneurysmal and non-aneurysmal tissue samples. CONCLUSIONS: Association testing of the functional positional candidate genes on the AAA1 locus on chromosome 19q13 demonstrated nominal association in three genes. PEPD and CD22 were considered the most promising candidate genes for altering AAA risk, based on gene function, association evidence, gene expression, and protein expression. [less ▲]

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See detailThe prosody of non-native speech
Rasier, Laurent ULg

Scientific conference (2011)

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See detailLes droits constitutionnels du contribuable
Bourgeois, Marc ULg; Traversa, Edoardo

in Les droits constitutionnels en Belgique - Les enseignements jurisprudentiels de la Cour constitutionnelle, du Conseil d'Etat et de la Cour de cassation (2011)

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See detailEntre parc et muséum: unité et diversité des musées de science et technique
Gob, André ULg

in Chaumier, Serge (Ed.) Expoland : Ce que le parc fait au musée : ambivalence des formes de l'exposition (2011)

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See detailCompte rendu : La chaussée romaine de Bavay à Tongres (coord.: Gérard Bavay et Bruno Merckx)
Baiwir, Esther ULg

in Wallonnes : Chronique de la Société de Langue et de Littérature Wallonnes (2011), 2

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See detailMaxwell rigidity and topological constraints in amorphous phase-change networks
Micoulaut, M.; Otjacques, C.; Raty, Jean-Yves ULg et al

in AIP Conference Proceedings (2011), 1393

By analyzing first-principles molecular-dynamics simulations of different telluride amorphous networks, we develop a method for the enumeration of radial and angular topological constraints, and show that ... [more ▼]

By analyzing first-principles molecular-dynamics simulations of different telluride amorphous networks, we develop a method for the enumeration of radial and angular topological constraints, and show that the phase diagram of the most popular system Ge-Sb-Te can be split into two compositional elastic phases: a tellurium rich flexible phase and a stressed rigid phase that contains most of the materials used in phase-change applications. This sound atomic scale insight should open new avenues for the understanding of phase-change materials and other complex amorphous materials from the viewpoint of rigidity. [less ▲]

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See detailTRANSMISSION ROUTES OF NOROVIRUSES, EMERGING HUMAN PATHOGENS IN FOOD “NORISK”
Mathijs, E; Stals, A; Denayer, S et al

Book published by Belgian Science Policy (2011)

A. Context Noroviruses are pathogens causing gastroenteritis and infections result in typical symptoms such as abdominal cramps, fever, watery diarrhea and other symptoms such as headaches, chills and ... [more ▼]

A. Context Noroviruses are pathogens causing gastroenteritis and infections result in typical symptoms such as abdominal cramps, fever, watery diarrhea and other symptoms such as headaches, chills and general myalgias, which usually last for 2 to 3 days. The illness is self-limiting in most cases. The NV genus contains 5 genogroups whereby genogroup I and II (GI and GII) comprise most of the human infective NV genotypes. Bovine and murine NV are classified respectively in genogroup III (GIII) and V (GV), while porcine NV are also classified in GII. Human infective (mainly GI and GII) noroviruses (NV) have increasingly been recognized as a global major cause of acute non-bacterial gastroenteritis, but sensitive detection is only possible by molecular methods, due to the unavailability of a cultivation system. Development of these molecular methods showed that NV could be responsible for 60 % and 77 % of all gastroenteritis cases with known etiology in the USA and in Europe, respectively. The fraction of NV outbreaks caused by consumption of contaminated foods is estimated to be 10 to 20 %. Food products can be contaminated through 2 main transmission routes: either pre-harvest contamination, whereby mostly fresh produce and bivalve shellfish are involved. Shellfish are contaminated by cultivation in contaminated water, while fresh produce can by contaminated by use of contaminated irrigation water or (post-) harvest contamination often involving an infected food handler or food picker. A broad range of food products are related to the latter transmission route. Detection of NV in foods is more difficult because detection of NV present at very low levels on the foods should be possible due to the low infectious dose. Therefore, (genomic material of) NV has to be extracted from the foods and has to be detected subsequently by a molecular detection method. Furthermore, NVs are present in several animal species, raising important questions about zoonotic transmission and potential animal reservoir. B. Objectives 1. The NV RNA detection methodology: elaboration, optimization and evaluation of a real-time PCR format and determination of specificity, sensitivity and robustness. Two protocols will be developed. A real-time RT-PCR protocol directed to detection of the acknowledged GGI and GGII strains involved in outbreaks to be used in the frame of control and surveillance by food authorities and food business operators to verify their products and production process. Another real-time RT PCR protocol directed towards a wide diversity of NV genogroups (including newly reported animal associated NV) to be used for research purposes to establish transmission routes and document circulating strains in the environment. 2. The sample preparation method: to evaluate the effectiveness of several virus concentration / viral RNA extraction and purification protocols from a variety of food matrices in particular seafoods and with emphasis on elaboration of an appropriate extraction producedure in fresh produce/ready-to-eat foods. 3. The routine detection of NVs in food stuffs (seafoods and fresh products): to develop and implement a standard protocol with establishment of appropriate controls for rapid screening of foods for the presence of NVs in accordance with the guidelines for officially approved analysis and harmonization and to generate information on the prevalence of NV strains in foods at retail, products and production processes under the control of food business operators and the primary production. 4. Elucidation of transmission routes (zoonosis hypothesis) through molecular tracing, with a global view on NV strains circulating among human, animal and also in food. 5. The tracing of outbreaks: scenario for coupling clinical data from NV outbreaks to their foodborne cause and risk evaluation. 6. The development of a risk profile on NV present in the food chain and animal species (strain types circulating, potential animal reservoir, zoonose, definition and incidence in at risk foods, link to epidemiological information). 7. Tracing of the genetic evolution of NVs: genetic profiles and emerging of recombinants C. Conclusions Objective 1: A multiplex real-time RT-PCR assay for simultaneous detection of human GI and GII NV in clinical samples was designed, with the successful inclusion of MNV-1 as real-time PCR IAC. Evaluation of this multiplex assay showed a high concordance between the multiplex assay and the corresponding singleplex PCR assays. Specificity analysis of the multiplex assay by testing a NV RNA reference panel and clinical GI and GII NV samples showed that specific amplification of NV GI and GII was possible. In addition, no cross-amplification was observed when subjecting a collection of bovine NV and other (non-NV) enteric viruses to the multiplex assay. Finally, MNV-1 was successfully integrated as IAC, although a sufficiently low concentration was needed to avoid interference with the possibility of the developed multiplex assay to quantitatively and simultaneously detect the presence of GI and GII NV within one sample. Persistent contamination problems leading to false-positive results were encountered, but an investigation was performed towards the source of the contamination. The problem could be controlled and only occasional contamination has been observed. Objective 2: Two protocols for extraction of NV from soft red fruits (selected as fresh produce product) and ready-to-eat (RTE) foods were evaluated towards robustness and sensitivity. For the RTE foods, the protocol for RTE foods made use of a guanidine isothiocyanate containing reagent to extract viral RNA from the food sample (basic protocol called TriShort) with an eventual concentration/purification step (extended protocol called TriConc). The protocol for extraction of NV from soft red fruits consisted of alkaline elution of NV particles from the food, followed by polyethylene glycol precipitation and organic solvent purification. After purification, the RNA was detected by the multiplex real-time RT-PCR assay optimized in objective 1. The influence of (1) the NV inoculum level and (2) different food types on the recovery of NV from these foods was investigated for both protocols. Overall, the elution –precipitation protocol was able to recover NV from soft red fruits with efficiencies of 10 % to 20 % in most cases while the protocol for RTE foods yielded recovery efficiencies of >1% (TriShort protocol) and 0.1 to 10 % (TriConc protocol). For both NV extraction methods, taking into account all dilution factors resulted in a detection limit of approximately 104 genomic copies/10g. Simultaneous recovery of GI and GII NV in similar or 100-fold different concentrations was possible in both food categories. A significant influence of the NV inoculum level on its recovery was noticeable in both protocols as high inoculum levels were recovered more successfully and with a higher efficiency compared to low level inocula in both protocols. This phenomenon, together with the influence of the food type on the recovery was more explicit on the protocol for RTE foods compared to the protocol for soft red fruits. Objective 3: The multiplex real-time RT-PCR assay described in objective 1 and the virus extraction protocols described in objective 2 were combined to two NV detection methods. The murine norovirus 1 (MNV-1), a cultivable genogroups V NV, was in these detection methods used and evaluated as control reagent. MNV-1 was used to control the entire virus detection protocol (process control; PC), the reverse transcription reaction (reverse transcription control; RTC) and the real-time PCR reaction (internal amplification control; IAC) when detecting NV in foods. Evaluation showed that MNV-1 PC and RTC could be used for detection of inefficient extraction and inhibition of the RT-PCR, respectively. On the other hand, the MNV-1 IAC provided only little added value and it was suggested to leave this control out. Objective 4: Screening of 75 fruit samples for NV presence was performed using the protocol for soft red fruits (objective 2) and the multiplex real-time RT-PCR assay (objective 1). MNV-1 was used as PC, RTC and IAC. A total of 18 samples tested positive for GI and/or GII NV despite good bacteriological quality. Results obtained showed the difficulty of expressing positive (real-time) PCR results towards terms of public health threat if no associated diseases or outbreaks are reported. Although these low NV levels might indicate virus contamination at some point during the fresh produce chain, care should be taken to translate these results as a significant risk to the public health. Nevertheless, a possible risk for food borne transmission of NV from these food products cannot be excluded either. Genotyping results from 115 clinical samples originating from gastro-enteritis epidemics reported to the Scientific Institute of Public Health allowed us to characterise the NV strains implicated in these outbreaks between 2007 and 2010. Similarly, the creation of a stool bank with domestic animal clinical samples and NV screening in these samples in the first part of the NORISK project have allowed the characterisation of animal NVs especially in the bovine and porcine species. These results confirm that bovine and porcine NVs may be endemic in our counties but besides these animal NVs, no other animal NV was detected in the other animal species selected for the stool bank. Objective 5: After the introduction of Norovirus specific analysis method in the surveillance of foodborne outbreaks, it became clear, that Norovirus is an important agent causing foodborne outbreaks in Belgium. During the last three years it was even the leading reported agent. It became also clear that it is not so easy to define the transmission routes of Norovirus. By the introduction of a scenario for gastro-enteritis a classification based on the possible transmission route was possible. In all the reported outbreaks no primary contaminated food like bivalve shellfish or red fruits was involved. Secondary contaminated food plays an imported role in the transmission of Norovirus with an infected food handler as a crucial vector. Besides the food related outbreaks it became clear that person-to person transmission and a high environmental contamination are risk factors in the further transmission of Norovirus in the population The fact that many people are living close together in for example youth camps or elderly homes, the common use of sanitary facilities and the common preparation of meals, combined with the high infectivity of Norovirus and the existence of asymptomatic carriers, results in highly vulnerable populations in these conditions. Although Norovirus infections often end up in a positive way, they may have a high impact on the health (eg elderly homes) and may cause a lot of costs (less personnel at work) and sorrow (eg closure of a youth camp). Although both the prevention and decrease of the risk of a Norovirus infection are not evident, some measures have to be taken. A good hand-, toilet- and kitchen hygiene, a good infrastructure and the rapid signaling of gastro-enteritis outbreaks can decrease the risk of Norovirus infection and might restrict further spread of the virus. The knowledge rising from the Norovirus outbreaks reported at the NRL FBO allowed use to formulate and publish specific measures and recommendations for Norovirus outbreaks, which help the inspectors and physicians in the rapid diagnosis and prevention of the further transmission of Norovirus outbreaks. Objective 6: Throughout the NORISK project, NVs were detected in different food matrices available for human consumption, in humans and in animals like cattle and pigs. For a better comprehension of NV transmission routes, sequences of the detected NVs were determined and submitted for further analysis. Genotyping of NVs in food matrices came out to be a real challenge and consisted into a bottleneck as the amount of genetic material on food was insufficient for PCR amplification and sequencing. This obstacle was not overcome during our project and NV sequences were only obtained from clinical samples in humans and animals. Interesting was that no animal NVs were detected in samples originating from humans and no human sequences were amplified from animal clinical samples. Thus, there is no evidence of a potential interspecies NV transmission and zoonotic transmissions seem unlikely to occur. However NV, being an RNA virus, exhibit great genomic plasticity and changes in its genome could lead to the emergence of new NV variant with different biological proprieties that should not be left out (objective 7). Objective 7: Sequences obtained in the human and bovine clinical samples show different NV strains that exhibit incoherent clustering for the partial sequences of the polymerase and the capsid region indicating that they might be recombinant. For the human NV strains, although the majority of the gastroenteritis outbreaks were involved with GII.4 NVs in 2007 and 2008, other GII NVs were detected from the end of 2008 to 2010 along GII.4 NVs. Among these NVs, a variety of new recombinants were detected in different samples from different outbreaks between 2008 and 2010. New « super » polymerase sequences (GII.e and GII.g) related to the previously described GII.b polymerase were detected in the same period. The exact significance of the emergence of these polymerases or their origin has yet to be elucidated but their involvement with different outbreaks might indicate that they have a selective advantage upon the capsid parental strains. Based on sequencing data, norovirus (NV) recombinants have been described, but no experimental evidence of recombination in NVs has been documented. Using the murine norovirus (MNV) model, we investigated the occurrence of genetic recombination between two co-infecting wild-type MNV isolates in RAW cells. The design of a PCR-based genotyping tool allowed accurate discrimination between the parental genomes and the detection of a viable recombinant MNV (Rec MNV) in the progeny viruses. Genetic analysis of Rec MNV identified a homologous-recombination event located at the ORF1–ORF2 overlap. Rec MNV exhibited distinct growth curves and produced smaller plaques than the wild-type MNV in RAW cells. Here, we demonstrate experimentally that MNV undergoes homologous recombination at the previously described recombination hot spot for NVs, suggesting that the MNV model might be suitable for in vitro studies of NV recombination. Moreover, the results show that exchange of genetic material between NVs can generate viruses with distinct biological properties from the parental viruses. [less ▲]

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See detailFormer des établissements de la petite enfance à l'approche interactive
Stambak, Mira; Pirard, Florence ULg; Amilhaud, Geneviève et al

in Hardy, Marianne; Belmont, Brigitte; Noël-Hureau, Elisabeth (Eds.) Des recherches-actions pour changer l'école. (2011)

The interactive pedagogy elaborated by the Cresas (in Paris) has influenced the educational practice and the professional accompaniment in the early childhood sector. It can be interpreted as a ... [more ▼]

The interactive pedagogy elaborated by the Cresas (in Paris) has influenced the educational practice and the professional accompaniment in the early childhood sector. It can be interpreted as a professionalization process where actions, actors, and environment undergo change simultaneously. [less ▲]

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See detailDihadron fragmentation functions and their relevance for transverse spin studies
Courtoy, Aurore ULg; Bacchetta, A.; Radici, M.

in Journal of Physics: Conference Series (2011), 295(1),

Dihadron fragmentation functions describe the probability that a quark fragments into two hadrons plus other undetected hadrons. In particular, the so-called interference fragmentation functions describe ... [more ▼]

Dihadron fragmentation functions describe the probability that a quark fragments into two hadrons plus other undetected hadrons. In particular, the so-called interference fragmentation functions describe the azimuthal asymmetry of the dihadron distribution when the quark is transversely polarized. They can be used as tools to probe the quark transversity distribution in the nucleon. Recent studies on unpolarized and polarized dihadron fragmentation functions are presented, and we discuss their role in giving insights into transverse spin distributions. [less ▲]

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See detailLes oligosaccharides pectiques: production et applications possibles
Combo, Agnan Marie Michel ULg; Mario, Aguedo ULg; Paquot, Michel ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2011), 15(1), 153-164

Les oligosaccharides pectiques ou POS sont des fragments de composition complexe issus de la dégradation chimique, physique ou enzymatique de la pectine. Du fait de l’intérêt de leurs propriétés ... [more ▼]

Les oligosaccharides pectiques ou POS sont des fragments de composition complexe issus de la dégradation chimique, physique ou enzymatique de la pectine. Du fait de l’intérêt de leurs propriétés biologiques, les oligosaccharides pectiques font l’objet de nombreuses études et trouvent aujourd’hui des applications dans des domaines aussi différents que la médecine, l’agriculture et l’industrie agro-alimentaire. Cet écrit présente la structure des pectines ainsi que les différents modes de production des POS en insistant particulièrement sur les différentes enzymes microbiennes permettant de les obtenir et sur les applications possibles de ces POS. [less ▲]

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