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See detailMalignant catarrhal fever induced by Alcelaphine herpesvirus 1 is characterized by an expansion of activated CD3+CD8+CD4- T cells expressing a cytotoxic phenotype in both lymphoid and non-lymphoid tissues.
Dewals, Benjamin G ULg; Vanderplasschen, Alain ULg

in Veterinary research (2011), 42(1), 95

ABSTRACT: Alcelaphine herpesvirus 1 (AlHV-1) is carried by wildebeest asymptomatically. It causes a fatal lymphoproliferative disease named wildebeest-derived malignant catarrhal fever (WD-MCF) when cross ... [more ▼]

ABSTRACT: Alcelaphine herpesvirus 1 (AlHV-1) is carried by wildebeest asymptomatically. It causes a fatal lymphoproliferative disease named wildebeest-derived malignant catarrhal fever (WD-MCF) when cross-species transmitted to a variety of susceptible species of the Artiodactyla order. WD-MCF can be reproduced experimentally in rabbits. In a previous report, we demonstrated that WD-MCF induced by AlHV-1 is associated with a severe proliferation of CD8+ T cells in the lymphoid tissues. Here, we further studied the mononuclear leukocytic populations in both the lymphoid (throughout the infection and at time of euthanasia) and non-lymphoid (at time of euthanasia) organs during WD-MCF induced experimentally in rabbits. To reach that goal, we performed multi-colour flow cytometry stainings. The results obtained demonstrate that the development of WD-MCF correlates in peripheral blood with a severe increase of CD8+ cell percentages; and that CD3+CD8+CD4- T cells were the predominant cell type in both lymphoid and non-lymphoid organs at time of euthanasia. Further characterization of the mononuclear leukocytes isolated from both lymphoid and non-lymphoid tissues revealed that the CD8+ T cells express high levels of the activation markers CD25 and CD44, produce high amount of gamma-interferon (IFN-gamma) and perforin, and showed a reduction of interleukin-2 (IL-2) gene expression. These data demonstrate that the development of WD-MCF is associated with the expansion and infiltration of activated and cytotoxic CD3+CD8+CD4- T cells secreting high amount of IFN-gamma but low IL-2. [less ▲]

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See detailBeyond matching on the mean in developmental disabilities research
Facon, Bruno; Magis, David ULg; Belmont, John M

in Research in Developmental Disabilities (2011), 32

The matching of groups is a traditional way to control for confounding variables in developmental disability research. The equivalency of means across groups is routinely checked for these variables, but ... [more ▼]

The matching of groups is a traditional way to control for confounding variables in developmental disability research. The equivalency of means across groups is routinely checked for these variables, but not the homogeneity of their variances or the shapes of their distributions. In the present paper, it is argued that group matching can go seriously wrong unless it directly confronts the distributional concerns by the use of well-known statistical indices and very simple graphical displays of the distributions. The question of the equivalency of item response profiles is also addressed since two participants or two groups of participants can obtain the same overall score on the matching variable by passing different items. In this case, the matching cannot be considered satisfactory because of poor concordance between the molar (overall score) and molecular (item scores) levels of matching. Angoff's Delta plot method, a statistical approach for detecting differential item functioning across small groups is described. It is promising as a simple way to prove whole test/individual item correspondence and, in addition, a useful tool for making post-hoc statistical analyses at the item level on the dependant variables. [less ▲]

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See detailGobernabilidad desde las agrupaciones usuarias del agua con fines agrícolas en 8 municipios del territorio de la Mancomunidad de Municipios de la cuenca del río Naranjo (MANCUERNA)
Estrada Orozco, Nick Kenner ULg; Mux, Victor

in Tikalia (2011), XXIX(1-2), 37-46

En Guatemala, para alcanzar los Objetivos de desarrollo del Milenio se implemen- tan Programas Conjuntos con el apoyo del Sistema de Naciones Unidas. Existen en la actualidad cinco Programas Conjuntos ... [more ▼]

En Guatemala, para alcanzar los Objetivos de desarrollo del Milenio se implemen- tan Programas Conjuntos con el apoyo del Sistema de Naciones Unidas. Existen en la actualidad cinco Programas Conjuntos apoyando temas de seguridad alimen- taria, construcción de la paz, cambio climático, género y gobernabilidad económi- ca del agua. En el marco del programa conjunto: “Gobernabilidad económica en agua y sanea- miento” se decidió realizar un estudio que permitiera conocer la gobernabilidad en el sector a partir de hacer un inventario de las agrupaciones usuarias de agua con fines agrícolas y conocer algunas de sus características, este estudio contó con la asesoría técnica de la Organización de las Naciones Unidas para la Agricultura y la Alimentación –FAO– y el apoyo en campo de las comunidades asociadas por el agua y el medio ambiente de la cuenca del río Naranjo –CADISNA– en coordina- ción con el Ministerio de Agricultura Ganadería y Alimentación –MAGA– y go- biernos locales. El estudio se realizó en 8 municipios, 3 del departamento de Quetzaltenango y 5 de San Marcos, se identificaron 126 grupos de riego, de ellos, 73 pudieron ser carac- terizados. Se conoció que el 92% de los 73 grupos tiene una junta directiva que vela por el funcionamiento del sistema y la producción se ve diversificada en al menos 14 diferentes hortalizas siendo la principal el cultivo de la Papa. Sin embar- go sólo el 45% paga una tarifa a su grupo y el 60% de los usuarios necesita crédito para poder producir, haciendo uso de al menos 271.99 Lts/seg de agua para fines agrícolas. [less ▲]

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See detailKurt Smith, Matter Matters. Metaphysics and Methodology in the Early Modern Period
Dubouclez, Olivier ULg

in Bulletin cartésien (2011)

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See detailQuantifying hyporheic exchange at high spatial resolution using natural temperature variations along a first order stream
Westhoff, Martijn ULg; Gooseff, M. N.; Bogaard, T. A. et al

in Water Resources Research (2011), 47

Hyporheic exchange is an important process that underpins stream ecosystem function, and there have been numerous ways to characterize and quantify exchange flow rates and hyporheic zone size. The most ... [more ▼]

Hyporheic exchange is an important process that underpins stream ecosystem function, and there have been numerous ways to characterize and quantify exchange flow rates and hyporheic zone size. The most common approach, using conservative stream tracer experiments and 1-D solute transport modeling, results in oversimplified representations of the system. Here we present a new approach to quantify hyporheic exchange and the size of the hyporheic zone (HZ) using high-resolution temperature measurements and a coupled 1-D transient storage and energy balance model to simulate in-stream water temperatures. Distributed temperature sensing was used to observe in-stream water temperatures with a spatial and temporal resolution of 2 and 3 min, respectively. The hyporheic exchange coefficient (which describes the rate of exchange) and the volume of the HZ were determined to range between 0 and 2.7 × 10−3 s−1 and 0 and 0.032 m3 m−1, respectively, at a spatial resolution of 1–10 m, by simulating a time series of in-stream water temperatures along a 565 m long stretch of a small first-order stream in central Luxembourg. As opposed to conventional stream tracer tests, two advantages of this approach are that exchange parameters can be determined for any stream segment over which data have been collected and that the depth of the HZ can be estimated as well. Although the presented method was tested on a small stream, it has potential for any stream where rapid (in regard to time) temperature change of a few degrees can be obtained. [less ▲]

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See detailMultiparametric observation and analysis of the Sea
Alvera Azcarate, Aïda ULg; Poulain, Pierre-Marie

in Ocean Dynamics (2011)

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See detailThe Dihadron fragmentation functions way to Transversity
Courtoy, Aurore ULg; Bacchetta, Alessandro; Radici, Marco

in AIP Conference Proceedings (2011)

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See detailDesigning optimal calcium phosphate scaffold-cell combinations using an integrative model-based approach.
Carlier, Aurélie ULg; Chai, Y.C.; Moesen, M. et al

in Acta Biomaterialia (2011), 7(10), 3573-85

Bone formation is a very complex physiological process, involving the participation of many different cell types and regulated by countless biochemical, physical and mechanical factors, including ... [more ▼]

Bone formation is a very complex physiological process, involving the participation of many different cell types and regulated by countless biochemical, physical and mechanical factors, including naturally occurring or synthetic biomaterials. For the latter, calcium phosphate (CaP)-based scaffolds have proven to stimulate bone formation, but at present still result in a wide range of in vivo outcomes, which is partly related to the suboptimal use and combination with osteogenic cells. To optimize CaP scaffold selection and make their use in combination with cells more clinically relevant, this study uses an integrative approach in which mathematical modeling is combined with experimental research. This paper describes the development and implementation of an experimentally informed bioregulatory model of the effect of calcium ions released from CaP-based biomaterials on the activity of osteogenic cells and mesenchymal stem cell driven ectopic bone formation. The amount of bone formation predicted by the mathematical model corresponds to the amount measured experimentally under similar conditions. Moreover, the model is also able to qualitatively predict the experimentally observed impaired bone formation under conditions such as insufficient cell seeding and scaffold decalcification. A strategy was designed in silico to overcome the negative influence of a low initial cell density on the bone formation process. Finally, the model was applied to design optimal combinations of calcium-based biomaterials and cell culture conditions with the aim of maximizing the amount of bone formation. This work illustrates the potential of mathematical models as research tools to design more efficient and cell-customized CaP scaffolds for bone tissue engineering applications. [less ▲]

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See detailAtlas linguistique de la Wallonie. Tome 17. Famille, vie et relations sociales
Baiwir, Esther ULg

Book published by PULg - Presses universitaires de Liège - Sciences Humaines (2011)

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See detailObservations of the rotational lines of OH in comets with the Herschel Space Observatory
Crovisier, J.; Bockelée-Morvan, D.; Biver, N. et al

in EPSC Abstracts 2011 (2011)

We present here a search for the OH rotational lines in these spectral scans. In comet 103P/Hartley 2, the 2 3/2(5/2)-2 3/2(3/2) lines at 119 μm and 2 1/2(5/2)-2 1/2(3/2) lines at 99 μm are detected ... [more ▼]

We present here a search for the OH rotational lines in these spectral scans. In comet 103P/Hartley 2, the 2 3/2(5/2)-2 3/2(3/2) lines at 119 μm and 2 1/2(5/2)-2 1/2(3/2) lines at 99 μm are detected. Other lines may be marginally present. Two mechanisms concur to the emission of the OH rotational lines: fluorescence due to solar excitation of the electronic states of OH [8] and prompt emission following the photodissociation of water, which produces the OH radical in electronic, vibrational and rotational excited states [9, 10]. We will compare the observed line intensities with those expected from these mechanisms, using the comet water productions determined from Herschel [6, 7], in order to better constrain the excitation of cometary OH. [less ▲]

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See detailSafety and Performance of Stochastic Targeted (STAR) Glycemic Control of Insulin and Nutrition – First Pilot Results
Shaw, Geoffrey M.; Le Compte, Aaron; Evans, Alicia et al

in Intensive Care Medicine (2011)

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See detailTomographic measurement of liquid hold up and effective interfacial area distributions in a column packed with high performance structured packings
Aferka, Saïd ULg; Viva, Aurora; Brunazzi, Elisabetta et al

in Chemical Engineering Science (2011), 66

In this paper, we report on the use of a high energy and high resolution X-ray tomograph to visualize and quantify the distribution of liquid hold up and of gas-liquid interfacial area in a 0.1m diameter ... [more ▼]

In this paper, we report on the use of a high energy and high resolution X-ray tomograph to visualize and quantify the distribution of liquid hold up and of gas-liquid interfacial area in a 0.1m diameter column filled with MellapakPlus 752.Y packing elements. A standard air-water system at room temperature and atmospheric pressure was used. Tomographic measurements have been carried out in a large number of packing cross sections situated at different heights between the top and the bottom of the packed column, giving access to the evolution of axial profiles of liquid hold up and of gas-liquid interfacial area as a function of the operating conditions. Gas-liquid interfacial area values were also measured by a chemical method (CO2 absorption from air into a caustic solution). For the first time, a whole set of gas-liquid interfacial area values evaluated from tomographic images are interestingly compared with values measured by a chemical method. A comparison is also presented with literature models. [less ▲]

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See detailA non-invasive approach to study lifetime exposure and bioaccumulation of PCBs in protected marine mammals: PBPK modeling in harbor porpoises
Weijs, Liesbeth; Covaci, Adrian; Yang, Raymond S. H. et al

in Toxicology and Applied Pharmacology (2011), 256

In the last decade, physiologically based pharmacokinetic (PBPK) models have increasingly been developed to explain the kinetics of environmental pollutants in wildlife. For marine mammals specifically ... [more ▼]

In the last decade, physiologically based pharmacokinetic (PBPK) models have increasingly been developed to explain the kinetics of environmental pollutants in wildlife. For marine mammals specifically, these models provide a new, non-destructive tool that enables the integration of biomonitoring activities and in vitro studies. The goals of the present study were firstly to develop PBPK models for several environmental relevant PCB congeners in harbor porpoises (Phocoena phocoena), a species that is sensitive to pollution because of its limited metabolic capacity for pollutant transformation. These models were tested using tissue data of porpoises from the Black Sea. Secondly, the predictive power of the models was investigated for time trends in the PCB concentrations in North Sea harbor porpoises between 1990 and 2008. Thirdly, attempts were made to assess metabolic capacities of harbor porpoises for the investigated PCBs. In general, results show that parameter values from other species (rodents, humans) are not always suitable in marine mammal models, most probably due to differences in physiology and exposure. The PCB 149 levels decrease the fastest in male harbor porpoises from the North Sea in a time period of 18†years, whereas the PCB 101 levels decrease the slowest. According to the models, metabolic breakdown of PCB 118 is probably of lesser importance compared to other elimination pathways. For PCB 101 and 149 however, the presence of their metabolites can be attributed to bioaccumulation of metabolites from the prey and to metabolic breakdown of the parent compounds in the harbor porpoises. [less ▲]

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See detailCross-reactivity of 25-hydroxy vitamin D2 from different commercial immunoassays for 25-hydroxy vitamin D: an evaluation without spiked samples.
CAVALIER, Etienne ULg; WALLACE, A. Michael; CARLISI, Ignazia ULg et al

in Clinical chemistry and laboratory medicine : CCLM / FESCC (2011), 49(3), 555-8

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See detail'Tu manges aujourd’hui, tu ne manges pas le lendemain, ça c’est la pauvreté'. L’incertitude alimentaire à Bamako
de Suremain, Charles-Edouard; Razy, Elodie ULg

in Arditi, P.; Janin, P.; Marie, A. (Eds.) "La lutte contre l'insécurité alimentaire au Mali. Réalités et faux semblants" (2011)

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See detailPancreas preservation for pancreas and islet transplantation: a minireview
SQUIFFLET, Jean-Paul ULg; LeDinh, Hieu; DE ROOVER, Arnaud ULg et al

in Transplantation Proceedings (2011), 43

Pancreas preservation by cold storage using University of Wisconsin solution was the <br />mainstay method used for pancreas transplantation during the past 2 decades. Other <br />solutions, such as HTK ... [more ▼]

Pancreas preservation by cold storage using University of Wisconsin solution was the <br />mainstay method used for pancreas transplantation during the past 2 decades. Other <br />solutions, such as HTK, Celsior, and SCOT 15, could not demonstrate any advantage for <br />short preservation periods. But the advent of clinical islet transplantation and the larger <br />use of controlled non–heart-beating donors have prompted the transplantation community <br />to develop methods for increasing pancreas graft quality while preventing ischemic <br />reperfusion damages. Oxygenation by 1- or 2-layer methods during pancreas preservation, <br />as well as the use of perfluorocarbons, might increase the islet yield. Based on the former <br />methods, there is a renewed interest in machine perfusion and oxygenation in pancreas <br />preservation for pancreas transplantation and islet preparation. [less ▲]

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See detailCouverture de pertes de substance du tibia distal par lambeau pedicule perforant en helice : deux cas cliniques.
Bous, Aurélie ULg; Ronsmans, C.; NIZET, Jean-Luc ULg et al

in Annales de Chirurgie Plastique Esthetique (2011)

Distal lower leg soft tissue defect is frequently a challenge to repair, particularly on the tibial crest. The coverage of this kind of lesion has some limitations because of regional minimal blood supply ... [more ▼]

Distal lower leg soft tissue defect is frequently a challenge to repair, particularly on the tibial crest. The coverage of this kind of lesion has some limitations because of regional minimal blood supply and paucity of local soft-tissue flaps. The perforator pedicled propeller (PPP) method tries to find a new place in lower leg reconstruction in bringing similar tissues at the recipient site and avoiding long and difficult free flap transfer or muscular sacrifice. The authors report on the use of PPP method for a tibial crest exposure after trauma and for a soft tissue defect with osteomyelitis on the tibial crest. [less ▲]

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See detailProfil des vendeurs de viande de chasse et évaluation de la biomasse commercialisée dans les marchés municipaux de Brazzaville, Congo.
Mbete, Roger Albert; Banga-Mboko, Henri; Ngokaka, Christophe et al

in Tropical Conservation Science (2011), 4(2), 203-217

The consumption of wildlife meat is an important source of animal protein for rural and urban population in Congo. A survey on bushmeat trade was undertaken in 21 municipal markets during four weeks, in ... [more ▼]

The consumption of wildlife meat is an important source of animal protein for rural and urban population in Congo. A survey on bushmeat trade was undertaken in 21 municipal markets during four weeks, in Brazzaville. The objective of this study was to define the traders’ profile and to evaluate the quantities of games and meat merchandised on the municipal markets. The study methodology combined two approaches: a quantitative one using a questionnaire as principal tool for collecting data, and a qualitative one associating informal survey methods via individual or group interviews. The results showed that women were the most involved in this trade (52%). Markets trader’s monthly income was estimated at 210,428 (US$420) ± 49,128 (US$98,256) FCFA. On average, the bushmeat traders’ were 39 ± 10 years old and 69% of them attended the two levels of secondary education. During four weeks, 3,711 animal carcasses were recorded on the 21 surveyed markets, representing almost 35,790 kg of biomass. Overall, 35 animal species were identified, including 9 the hunting of which was prohibited. The mammals constituted 93.8% of total number of hunted animals, with three dominant orders as the artiodactyls (49.2%), the rodents (22.6%) and the primates (17.7%), of which the Cephalophus, the Potamochoerus, the Atherurus and the Cercopithecus were the most represented. It was also noticed that trapping, an activity which leads to great losses, becomes very important, followed by be helpful alternatives to meet Congolese demand for bushmeat. For a sustainable management of the Congo’s faunic resources, this study suggests the introduction gun-hunting. The Congo-Ocean Railway and the National Road n°2 were used regularly in the transportation of game, to a 72% level. The district of Niari, Lekoumou, Sangha and Pool were the main sources of supply. At the present time, the meat quantities offered in Brazzaville markets don’t seem to be reduced because hunting areas extend always further, often to the detriment of protected areas. Despite the fact that such business squarely growths and shows evidence of overexploitation, activities promoting game farming and breeding of domestic species, in Brazzaville suburbs, are needed to mitigate the impact of bushmeat trade. [less ▲]

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See detailRés. CE 212.819, Smolcic - 212.989, Vanderlinden - 212.991, Fernandez-Grandjean
Delnoy, Michel ULg

in Aménagement - Environnement (2011), 4

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