References of "2011"
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See detailFormer des établissements de la petite enfance à l'approche interactive
Stambak, Mira; Pirard, Florence ULg; Amilhaud, Geneviève et al

in Hardy, Marianne; Belmont, Brigitte; Noël-Hureau, Elisabeth (Eds.) Des recherches-actions pour changer l'école. (2011)

The interactive pedagogy elaborated by the Cresas (in Paris) has influenced the educational practice and the professional accompaniment in the early childhood sector. It can be interpreted as a ... [more ▼]

The interactive pedagogy elaborated by the Cresas (in Paris) has influenced the educational practice and the professional accompaniment in the early childhood sector. It can be interpreted as a professionalization process where actions, actors, and environment undergo change simultaneously. [less ▲]

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See detailExternal Evaluation Report Über Die Common Security and Defence Policy Modules
Paile, Sylvain ULg

Book published by Ministry of Defence and Sports of the Federal Republic of Austria (2011)

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See detailSeeing the self disappear from the brain.
Guldenmund, Justus Pieter ULg

Speech (2011)

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See detailMucosal gene expression of cell adhesion molecules, chemokines, and chemokine receptors in patients with inflammatory bowel disease before and after infliximab treatment.
Arijs, Ingrid; De Hertogh, Gert; Machiels, Kathleen et al

in Acta Gastro-Enterologica Belgica (2011), 106(4), 748-61

OBJECTIVES: Inflammatory bowel disease (IBD) is characterized by a continuous influx of leukocytes into the gut wall. This migration is regulated by cell adhesion molecules (CAMs), and selective ... [more ▼]

OBJECTIVES: Inflammatory bowel disease (IBD) is characterized by a continuous influx of leukocytes into the gut wall. This migration is regulated by cell adhesion molecules (CAMs), and selective antimigration therapies have been developed. This study investigated the effect of infliximab therapy on the mucosal gene expression of CAMs in IBD. METHODS: Mucosal gene expression of 69 leukocyte/endothelial CAMs and E-cadherin was investigated in 61 IBD patients before and after first infliximab infusion and in 12 normal controls, using Affymetrix gene expression microarrays. Quantitative reverse transcriptase-PCR (qRT-PCR), immunohistochemistry, and western blotting were used to confirm the microarray data. RESULTS: When compared with control colons, the colonic mucosal gene expression of most leukocyte/endothelial adhesion molecules was upregulated and E-cadherin gene expression was downregulated in active colonic IBD (IBDc) before therapy, with no significant colonic gene expression differences between ulcerative colitis and colonic Crohn's disease. Infliximab therapy restored the upregulations of leukocyte CAMs in IBDc responders to infliximab that paralleled the disappearance of the inflammatory cells from the colonic lamina propria. Also, the colonic gene expression of endothelial CAMs and of most chemokines/chemokine receptors returned to normal after therapy in IBDc responders, and only CCL20 and CXCL1-2 expression remained increased after therapy in IBDc responders vs. control colons. When compared with control ileums, the ileal gene expression of MADCAM1, THY1, PECAM1, CCL28, CXCL1, -2, -5, -6, and -11, and IL8 was increased and CD58 expression was decreased in active ileal Crohn's disease (CDi) before therapy, and none of the genes remained dysregulated after therapy in CDi responders vs. control ileums. This microarray study identified a number of interesting targets for antiadhesion therapy including PECAM1, IL8, and CCL20, besides the currently studied alpha4beta7 integrin-MADCAM1 axis. CONCLUSIONS: Our data demonstrate that many leukocyte/endothelial CAMs and chemokines/chemokine receptors are upregulated in inflamed IBD mucosa. Controlling the inflammation with infliximab restores most of these dysregulations in IBD. These results show that at least part of the mechanism of anti-tumor necrosis factor-alpha therapy goes through downregulation of certain adhesion molecules. [less ▲]

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See detailNanobodies as structural probes to investigate the mechanism of fibril formation by the amyloidogenic variants of human lysozyme
Dumont, Janice ULg; Pardon, Els; Aumont-Nicaise, Magalie et al

Poster (2011)

Six variants of human lysozyme (single-point mutations I56T, F57I, W64R, D67H and double mutations F57I/T70N, W112R/T70N) are associated with a hereditary non-neuropathic systemic amyloidose. These ... [more ▼]

Six variants of human lysozyme (single-point mutations I56T, F57I, W64R, D67H and double mutations F57I/T70N, W112R/T70N) are associated with a hereditary non-neuropathic systemic amyloidose. These proteins form extracellular amyloid fibrils that deposit in a wide range of tissues and organs such as liver, spleen and kidneys where they cause damages [1]. It was shown that the D67H and I56T mutations cause a loss in stability and more particularly a loss of global cooperativity of protein [1]. Consequently, under physiologically relevant conditions, these variants can transiently populate a partially unfolded state in which the beta-domain and the C-helix are cooperatively unfolded while the rest of the protein remains native like [1]. The formation of intermolecular interactions between the regions that are unfolded in this intermediate state is likely to be a fundamental trigger of the aggregation process that ultimately leads to the formation and deposition of fibrils in tissues. We have also shown that the binding of three variable domain of camelid antibodies or (VHHs) - raised against the wild type human lysozyme inhibit in vitro the formation of amyloid fibrils by the lysozyme variants. These three VHHs bind on different regions of lysozyme and act as amyloid fibrils inhibitor through different mechanisms [2, 3, and unpublished results]. In the present work, sixteen new VHHs specific of human lysozyme have been generated. Competition experiments have shown that they bind to five non overlapping epitopes. We have demonstrated that five of these new VHHs are able to bind lysozyme in conditions used for amyloid fibril formation, and interestingly two of them recognize two epitopes that are different from those of the three VHHs previously characterized [2, 3, and unpublished results]. The effects of these new VHHs on the properties of lysozyme variants such as activity, stability, cooperativity and aggregation will be discussed. [less ▲]

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See detailA multicentric evaluation of IDMS-traceable creatinine enzymatic assays
Pieroni, Laurence; DELANAYE, Pierre ULg; Boutten, Anne et al

in Clinica Chimica Acta (2011), 412

Chronic kidney disease definition is based on glomerular filtration rate (GFR) estimations which are derived from creatinine-based equations. The accuracy of GFR estimation is thus largely dependent of ... [more ▼]

Chronic kidney disease definition is based on glomerular filtration rate (GFR) estimations which are derived from creatinine-based equations. The accuracy of GFR estimation is thus largely dependent of those of serum creatinine assays. International recommendations highlight the need for traceable creatinine assays. The French Society of Clinical Biochemistry conducted a study for measuring accuracy of creatinine enzymatic methods. This evaluation involved 25 clinical laboratories. Creatinine was measured in serum pools ranging from 35.9±0.9 μmol/L to 174.5±3.1 μmol/L (IDMS determination) using 12 creatinine enzymatic methods. For all creatinine values greater than 74.4±1.4 μmol/L, the bias and imprecision did not exceed 5% and 5.9%, respectively. For the lowest value (35.9±0.9 μmol/L), the bias ranged from −1.8 to 9.9% (with one exception). At this level, the imprecision ranged from 1.9 to 7.8%. The true performances of the assays (couples of bias and relative standard deviation), were evaluated using Monte-Carlo simulations. Most of the assays fall within the maximum Total Error of 12% at all concentrations. This study demonstrates substantial improvements in the calibration, traceability and precision of the enzymatic methods, reaching the NKDEP recommendations. Moreover, most of these assays allowed accurate creatinine measurements for creatinine levels lower than 40 μmol/L. [less ▲]

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See detailState of the Art of Existing Early Design Simulation Tools for Net Zero Energy Buildings: A Comparison of Ten Tools
Attia, Shady ULg

Report (2011)

Given the challenges to design Net Zero Energy Buildings (NZEBs) the use of Building Performance Simulation (BPS) tools during early design phases has been indispensable. In this context, BPS techniques ... [more ▼]

Given the challenges to design Net Zero Energy Buildings (NZEBs) the use of Building Performance Simulation (BPS) tools during early design phases has been indispensable. In this context, BPS techniques can be supportive when integrated early in the design process. However, architects suffer from BPS tools limitations during this decisive phase that addresses more the building geometry and envelope. To identify those limitations and as part of the International Energy Agency (IEA) Task 40: Towards Net Zero Energy Buildings, this report compares ten early design BPS tools. The aim is to define the potential of using and integrating the tools by architect during the design of NZEBs. The examined tools include HEED, e-Quest, ENERGY-10, Vasari, Solar Shoebox, Open Studio Plug-in, IES-VE- Ware, DesignBuilder, ECOTECT and BEopt. The comparison is based on five criteria including usability, optimization, interoperability, accuracy and design process integration of the tools. The results describe tools limitations and major requirements to meet the NZEBs objective implications. [less ▲]

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See detailIncome taxation of couples and the tax unit choice
Pestieau, Pierre ULg; Cremer, H., Lozachmeur, J-M.

in Journal of Population Economics (2011)

We study the optimal income taxation of couples. We determine the resulting intra-family labor supply allocation and its implication for the choice of the tax unit (individual versus joint taxation). We ... [more ▼]

We study the optimal income taxation of couples. We determine the resulting intra-family labor supply allocation and its implication for the choice of the tax unit (individual versus joint taxation). We provide a general condition for full joint taxation to arise. We also study how the spouses’ respective labor supply decisions are distorted when the condition does not hold. In particular, we show that, depending on the pattern of mating, the celebrated result according to which the spouse with the more elastic labor supply faces the lower marginal tax rates may or may not hold in our setting. [less ▲]

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See detailCompte rendu : Joseph BEAUJEAN, «Auteurs de dictionnaires et autres documents où l'on trouve les noms en wallon "liégeois" de plantes sauvages, utilitaires ou ornementales»
Baiwir, Esther ULg

in Wallonnes : Chronique de la Société de Langue et de Littérature Wallonnes (2011), 2

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See detailTowards min max generalization in reinforcement learning
Fonteneau, Raphaël ULg; Murphy, Susan; Wehenkel, Louis ULg et al

in Filipe, Joaquim; Fred, Ana; Sharp, Bernadette (Eds.) Agents and Artificial Intelligence: International Conference, ICAART 2010, Valencia, Spain, January 2010, Revised Selected Papers (2011)

In this paper, we introduce a min max approach for addressing the generalization problem in Reinforcement Learning. The min max approach works by determining a sequence of actions that maximizes the worst ... [more ▼]

In this paper, we introduce a min max approach for addressing the generalization problem in Reinforcement Learning. The min max approach works by determining a sequence of actions that maximizes the worst return that could possibly be obtained considering any dynamics and reward function compatible with the sample of trajectories and some prior knowledge on the environment. We consider the particular case of deterministic Lipschitz continuous environments over continuous state spaces, nite action spaces, and a nite optimization horizon. We discuss the non-triviality of computing an exact solution of the min max problem even after reformulating it so as to avoid search in function spaces. For addressing this problem, we propose to replace, inside this min max problem, the search for the worst environment given a sequence of actions by an expression that lower bounds the worst return that can be obtained for a given sequence of actions. This lower bound has a tightness that depends on the sample sparsity. From there, we propose an algorithm of polynomial complexity that returns a sequence of actions leading to the maximization of this lower bound. We give a condition on the sample sparsity ensuring that, for a given initial state, the proposed algorithm produces an optimal sequence of actions in open-loop. Our experiments show that this algorithm can lead to more cautious policies than algorithms combining dynamic programming with function approximators. [less ▲]

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See detailFinal results of a phase IIa, randomised, open-label trial to evaluate the percutaneous intramyocardial transplantation of autologous skeletal myoblasts in congestive heart failure patients: the SEISMIC trial.
Duckers, Henricus J.; Houtgraaf, Jaco; Hehrlein, Christoph et al

in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology (2011), 6(7), 805-12

AIMS: The SEISMIC study was an open-label, prospective, randomised study to assess the safety and feasibility of percutaneous myoblast implantation in heart failure patients with implanted cardioverter ... [more ▼]

AIMS: The SEISMIC study was an open-label, prospective, randomised study to assess the safety and feasibility of percutaneous myoblast implantation in heart failure patients with implanted cardioverter-defibrillators (ICD). METHODS AND RESULTS: Patients were randomised 2:1 to autologous skeletal myoblast therapy vs. optimal medical treatment. The primary safety end-point was defined as the incidence of procedural and device related serious adverse events, whereas the efficacy endpoints were defined as the change in global LVEF by MUGA scan, change in NYHA classification of heart failure and in the distance achieved during a six-minute walk test (6MW) at 6-month follow-up. Forty subjects were randomised to the treatment arm (n=26), or to the control arm (n=14). There were 12 sustained arrhythmic events and one death after episodes of ventricular tachycardia (VT) in the treatment group and 14 events in the control group (P=ns). At 6-month follow-up, 6MW distance improved by 60.3+/-54.1?meters in the treated group as compared to no improvement in the control group (0.4+/-185.7?meters; P=ns). In the control group, 28.6% experienced worsening of heart failure status (4/14), while 14.3% experienced an improvement in NYHA classification (2/14). In the myoblast-treatment arm, one patient experienced a deterioration in NYHA classification (8.0%), whereas five patients improved one or two classes (20.0%; P=0.06). However, therapy did not improve global LVEF measured by MUGA at 6-month follow-up. CONCLUSIONS: These data indicate that implantation of myoblasts in patients with HF is feasible, appears to be safe and may provide symptomatic relief, though no significant effect was detected on global LVEF. [less ▲]

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See detailTransient yielding during compression tests on ECAP’ed AA1050 Aluminium
Verlinden, Bert; Chen, Enze; Duchene, Laurent ULg et al

in Materials Science Forum (2011), 667-669

In most papers dealing with tension and/or compression tests, the conventional yield stress is determined either by an offset method (usually 0.2% strain) or by back extrapolation from the stress-strain ... [more ▼]

In most papers dealing with tension and/or compression tests, the conventional yield stress is determined either by an offset method (usually 0.2% strain) or by back extrapolation from the stress-strain curve. In our experiments on ECAP‟ed Aluminium a transient hardening saturation (THS) is always observed during the compression tests, but not during the tensile tests. This THS occurs at a significantly lower stress than the conventional yield stress. The aim of the present paper is to determine which the “real” start of yielding is. Two different experimental approaches have been adopted, confirming that the THS stage is exactly the yielding stage. This is not unimportant because it increases the tension-compression asymmetry and hence the back-stress and kinematic hardening. The reason for this different behaviour between tension and compression can be ascribed to a different change in strain path with respect to the ECAP deformation. [less ▲]

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See detailAcetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase.
Guarani, Virginia; Deflorian, Gianluca; Franco, Claudio A et al

in Nature (2011), 473(7346), 234-8

Notch signalling is a key intercellular communication mechanism that is essential for cell specification and tissue patterning, and which coordinates critical steps of blood vessel growth. Although subtle ... [more ▼]

Notch signalling is a key intercellular communication mechanism that is essential for cell specification and tissue patterning, and which coordinates critical steps of blood vessel growth. Although subtle alterations in Notch activity suffice to elicit profound differences in endothelial behaviour and blood vessel formation, little is known about the regulation and adaptation of endothelial Notch responses. Here we report that the NAD(+)-dependent deacetylase SIRT1 acts as an intrinsic negative modulator of Notch signalling in endothelial cells. We show that acetylation of the Notch1 intracellular domain (NICD) on conserved lysines controls the amplitude and duration of Notch responses by altering NICD protein turnover. SIRT1 associates with NICD and functions as a NICD deacetylase, which opposes the acetylation-induced NICD stabilization. Consequently, endothelial cells lacking SIRT1 activity are sensitized to Notch signalling, resulting in impaired growth, sprout elongation and enhanced Notch target gene expression in response to DLL4 stimulation, thereby promoting a non-sprouting, stalk-cell-like phenotype. In vivo, inactivation of Sirt1 in zebrafish and mice causes reduced vascular branching and density as a consequence of enhanced Notch signalling. Our findings identify reversible acetylation of the NICD as a molecular mechanism to adapt the dynamics of Notch signalling, and indicate that SIRT1 acts as rheostat to fine-tune endothelial Notch responses. [less ▲]

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See detailLe personnage au carrefour du médiatique et du social: Une analyse des débuts de « l’affaire Calice » à la RTBF
Devresse, Jenifer ULg

in Quaderni : la Revue de la Communication (2011), 74

Que font les médias au social ? Comment le récit de l’information peut-il faire sens ? Comment l’information télévisuelle dispose-t-elle de son public ? Autant de questions qui interrogent les mécanismes ... [more ▼]

Que font les médias au social ? Comment le récit de l’information peut-il faire sens ? Comment l’information télévisuelle dispose-t-elle de son public ? Autant de questions qui interrogent les mécanismes de construction sociale du sens, au carrefour du récit médiatique et de sa "réception". Espérant contribuer de la sorte à l’appréhension de ces mécanismes, cet article souligne, à travers une étude de cas, l’intérêt pour l’analyse des médias de la notion de personnage narratif. Il invite à voir dans ce personnage média-informé l’une des clés fondamentales qui préside à la détermination des possibles de la réception télévisuelle – et a fortiori de l’engagement. Analysant le système des personnages de « l’affaire Calice » tels que mis en scène dans les JT de la RTBF, l’étude examine ainsi la manière dont les positions spectatorielles induites par le récit des débuts de l’affaire tendent à déterminer certaines dispositions du public-acteur social. [less ▲]

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See detailContrats de mariage: entre conventions et controverses
Leleu, Yves-Henri ULg

in Le défi du notaire (2011)

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See detailSuper-heated Steam Drying: an Innovation of Clean Coal Technology for Lignite
Li, Sheng; Jiang, Bing; Shi, Yongchun et al

Conference (2011)

A comprehensive overview of the status of lignite pre-drying technology is given in this study. The practical problems of high energy consumption, high investment and poor safety exist in the lignite ... [more ▼]

A comprehensive overview of the status of lignite pre-drying technology is given in this study. The practical problems of high energy consumption, high investment and poor safety exist in the lignite drying using the traditional thermal drying, for the reason that the super-heated steam drying technology for lignite is put forward. The mechanism experiment research and pilot-scale test research of the super-heated steam drying technology for lignite were carried out, and the results show that the drying efficiency of the super-heated steam is better than the hot air at given conditions, the lignite drying can be accomplished stably and continuously and the drying product can meet the requirement of the industrial application of the lignite fired power plant. A more innovative approach as a new lignite Super-heated steam low-rank Coal Upgrading (SCU) is proposed by Energy Conservation Research Center of Shandong Academy of Sciences. The technical advancement in terms of energy-saving and safety among the applied technologies are compared and analyzed, and the results show this technology has the advantages of low energy consumption, high safety and energy saving. To sum up, the exploitation of the super-heated steam drying technology for lignite fired power plant can promote the development of the energy and power industry, and the technology has wide application prospect. [less ▲]

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See detailAction des cultures protectrices : cas des germes lactiques sur la flore alimentaire indésirable.
Privat, Kouakou; Thonart, Philippe ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2011), 15(2), 339-348

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