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See detailIs there really an Azores diversity enigma? Insights from the phylogeography of the heather Erica scoparia s.l.
Desamore, Aurélie ULg

Poster (2011)

The Azorean flora, in contrast to that of other archipelagos, is characterized by a paucity of evolutionary radiations and the widespread distribution of most endemics. Several hypotheses, including ... [more ▼]

The Azorean flora, in contrast to that of other archipelagos, is characterized by a paucity of evolutionary radiations and the widespread distribution of most endemics. Several hypotheses, including isolation from the continent, recent age, ecological homogeneity, and limited paleoclimatic variations, have been proposed to account for this pattern. These hypotheses are tested here within the context of the molecular phylogeography of the heather Erica scoparia s.l., a Mediterraneo-Atlantic species complex distributed across Macaronesia, North Africa and southwestern Europe. The marked molecular radiation of this species in the Azores, including an array of single-island endemics, suggests that the apparent homogeneity of the Azorean flora might, in fact, conceal undetected patterns of endemism that are similar to those observed in the Canarian flora for morphological data. Haplotype richness was higher in the Azores than in the Canaries and extensive dispersal mediated allopatry is apparent at the molecular level. The Azores were colonized at least twice independently by E. scoparia, whereas the Canarian haplotypes are monophyletic, suggesting that the greater distance between the Azores and the continent does not necessarily hamper the chances of successful colonization. [less ▲]

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See detailAtlas linguistique de la Wallonie. Tome 17. Famille, vie et relations sociales
Baiwir, Esther ULg

Book published by PULg - Presses universitaires de Liège - Sciences Humaines (2011)

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See detailA hybrid bioregulatory model of angiogenesis during bone fracture healing
Peiffer, Veronique; Gerisch, Alf; Vandepitte, Dirk et al

in Biomechanics & Modeling in Mechanobiology (2011), 10(3), 383-395

Bone fracture healing is a complex process in which angiogenesis or the development of a blood vessel net work plays a crucial role. In this paper, a mathematicalmodel is presented that simulates the ... [more ▼]

Bone fracture healing is a complex process in which angiogenesis or the development of a blood vessel net work plays a crucial role. In this paper, a mathematicalmodel is presented that simulates the biological aspects of fracture healing including the formation of individual blood vessels. The model consists of partial differential equations, several of which describe the evolution in density of the most important cell types, growth factors, tissues and nutrients. The other equations determine the growth of blood vessels as a result of themovement of leading endothelial (tip) cells. Branching and anastomoses are accounted for in the model. The model is applied to a normal fracture healing case and subjected to a sensitivity analysis. The spatiotemporal evolution of soft tissues and bone, as well as the development of a blood vessel network are corroborated by comparison with experimental data. Moreover, this study shows that the proposed mathematical framework can be a useful tool in the research of impaired healing and the design of treatment strategies. [less ▲]

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See detailSubtrochanteric fractures after long-term treatment with bisphosphonates: a European Society on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, and International Osteoporosis Foundation Working Group Report.
Rizzoli, R.; Akesson, K.; Bouxsein, M. et al

in Osteoporosis International (2011), 22

This paper reviews the evidence for an association between atypical subtrochanteric fractures and long-term bisphosphonate use. Clinical case reports/reviews and case-control studies report this ... [more ▼]

This paper reviews the evidence for an association between atypical subtrochanteric fractures and long-term bisphosphonate use. Clinical case reports/reviews and case-control studies report this association, but retrospective phase III trial analyses show no increased risk. Bisphosphonate use may be associated with atypical subtrochanteric fractures, but the case is yet unproven. INTRODUCTION: A Working Group of the European Society on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis and the International Osteoporosis Foundation has reviewed the evidence for a causal association between subtrochanteric fractures and long-term treatment with bisphosphonates, with the aim of identifying areas for further research and providing recommendations for physicians. METHODS: A PubMed search of literature from 1994 to May 2010 was performed using key search terms, and articles pertinent to subtrochanteric fractures following bisphosphonate use were analysed. RESULTS: Several clinical case reports and case reviews report a possible association between atypical fractures at the subtrochanteric region of the femur in bisphosphonate-treated patients. Common features of these 'atypical' fractures include prodromal pain, occurrence with minimal/no trauma, a thickened diaphyseal cortex and transverse fracture pattern. Some small case-control studies report the same association, but a large register-based study and retrospective analyses of phase III trials of bisphosphonates do not show an increased risk of subtrochanteric fractures with bisphosphonate use. The number of atypical subtrochanteric fractures in association with bisphosphonates is an estimated one per 1,000 per year. It is recommended that physicians remain vigilant in assessing their patients treated with bisphosphonates for the treatment or prevention of osteoporosis and advise patients of the potential risks. CONCLUSIONS: Bisphosphonate use may be associated with atypical subtrochanteric fractures, but the case is unproven and requires further research. Were the case to be proven, the risk-benefit ratio still remains favourable for use of bisphosphonates to prevent fractures. [less ▲]

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See detailMultiparametric observation and analysis of the Sea
Alvera Azcarate, Aïda ULg; Poulain, Pierre-Marie

in Ocean Dynamics (2011)

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See detailTolerability of shortened infliximab infusion times in patients with inflammatory bowel disease: a single center cohort study
Breynaert, C; Ferrante, F; Fidder, H et al

in Acta Gastro-Enterologica Belgica (2011)

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See detailBenthic remineralization in the northwest European continental margin (northern Bay of Biscay)
Suykens, Kim; Schmidt, Sabine; Delille, Bruno ULg et al

in Continental Shelf Research (2011), 31

We report a dataset of sediment characteristics and biogeochemical fluxes at the watersediment interface at the northwest European continental margin (northern Bay of Biscay). Cores were obtained in June ... [more ▼]

We report a dataset of sediment characteristics and biogeochemical fluxes at the watersediment interface at the northwest European continental margin (northern Bay of Biscay). Cores were obtained in June 2006, May 2007 and 2008, at 18 stations on the shelf break (120 to 180 m), and at 2 stations on the continental slope (520 m and 680 m). Water-sediment fluxes of dissolved oxygen (O2), total alkalinity (TA), nitrate (NO3-), and dissolved silicate (DSi) were measured at a total of 20 stations. Sediment characteristics include: grain size, chlorophyll-a (Chl-a) and phaeopigment (Phaeo) content, particulate organic (POC) and inorganic (PIC) carbon content, and lead-210 (210Pb) and thorium-234 (234Th) activities. Sediments were sandy (fine to coarse) with organic matter (OM) (1.0 - 4.0 %) and Chl-a (0.01 - 0.95 μg g-1) contents comparable to previous investigations in the same region, and a relatively high PIC fraction (0.8 - 10.2 %). Water-sediment O2 fluxes (-2.4 to -8.4 mmol O2 m-2 d-1) were low compared to other coastal environments and correlated well with OM and Chl-a content. 234Th activity profiles indicated that Chl-a sediment content was mainly controlled by physical mixing processes related to local hydrodynamics. The correlation between water-sediment fluxes of O2 and NO3- indicated a close coupling of nitrification/denitrification and total benthic organic carbon degradation. Dissolution of biogenic silica (0.05 to 0.95 mmol m-2 d-1) seemed uncoupled from organic carbon degradation, as characterized by water-sediment O2 fluxes. The link between water-sediment fluxes of TA and O2 indicated the occurrence of metabolic driven dissolution of calcium carbonates (CaCO3) in the sediments (~ 0.33 ± 0.47 mmol m-2 d-1) which represented ~ 1 % of the pelagic calcification rates due to coccolithophores measured during the cruises. These CaCO3 dissolution rates were below those reported in sediments of continental slopes and of the deep ocean, probably due to the high over-saturation with respect to CaCO3 of the water column overlying the continental shelf sediments of the northern Bay of Biscay. Rates of total benthic organic carbon degradation were low compared to water column rates of primary production and aphotic community respiration obtained during the cruises. [less ▲]

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See detailMathematical modeling of cell-cell and cell-matrix adhesion in tissue engineering using continuum models
Geris, Liesbet ULg; Gerisch, A.

in Geffen, A. (Ed.) Cellular and Biomolecular Mechanics and Mechanobiology (2011)

Key factors in the formation of cell aggregates in tissue engineering and other fields are the cell-cell and cell-matrix interactions. Other important factors are culture conditions such as nutrient and ... [more ▼]

Key factors in the formation of cell aggregates in tissue engineering and other fields are the cell-cell and cell-matrix interactions. Other important factors are culture conditions such as nutrient and oxygen supply and the characteristics of the environment (medium versus hydrogel). As mathematical models are increasingly used to investigate biological phenomena, it is important that processes such as cell adhesion are adequately described in the models. Recently a technique was developed to incorporate cell-cell and cell-matrix adhesion in continuum models through the use of non-local terms. In this study we apply this technique to model adhesion in a cell-in-gel culture set-up often found in tissue engineering applications. We briefly describe the biological issues underlying this study and the various modeling techniques used to capture adhesive behaviour. We furthermore elaborate on the numerical techniques that were developed in the course of this study. Finally, we consider a tissue engineering model that describes the spatiotemporal evolution of the concentration of cells, matrix, hydrogel, matrix degrading enzymes and oxygen/nutrients in a cell-in-gel culture system. Sensitivity analyses indicate a clear influence of the different adhesive processes on the final cell and collagen density and distribution, demonstrating the significance of cell adhesion in tissue engineering and the potential of the proposed mathematical technique. [less ▲]

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See detailCe que m'ont appris, dans une joyeuse valse à trois temps, mes maitres en didactique du français
Van Beveren, Julien ULg

in Lettre de l'AiRDF (2011), 50

Nous avons tenté de cerner, dans cet article, les principaux apports des enseignements de nos trois maitres en didactique du français : Micheline Dispy, Jean-Louis Dumortier et Georges Legros. Ce texte ... [more ▼]

Nous avons tenté de cerner, dans cet article, les principaux apports des enseignements de nos trois maitres en didactique du français : Micheline Dispy, Jean-Louis Dumortier et Georges Legros. Ce texte trouve sa place dans un numéro "anniversaire" de la "Lettre de l'Association internationale pour la Didactique du Français". [less ▲]

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See detailPancreas preservation for pancreas and islet transplantation: a minireview
SQUIFFLET, Jean-Paul ULg; LeDinh, Hieu; DE ROOVER, Arnaud ULg et al

in Transplantation Proceedings (2011), 43

Pancreas preservation by cold storage using University of Wisconsin solution was the <br />mainstay method used for pancreas transplantation during the past 2 decades. Other <br />solutions, such as HTK ... [more ▼]

Pancreas preservation by cold storage using University of Wisconsin solution was the <br />mainstay method used for pancreas transplantation during the past 2 decades. Other <br />solutions, such as HTK, Celsior, and SCOT 15, could not demonstrate any advantage for <br />short preservation periods. But the advent of clinical islet transplantation and the larger <br />use of controlled non–heart-beating donors have prompted the transplantation community <br />to develop methods for increasing pancreas graft quality while preventing ischemic <br />reperfusion damages. Oxygenation by 1- or 2-layer methods during pancreas preservation, <br />as well as the use of perfluorocarbons, might increase the islet yield. Based on the former <br />methods, there is a renewed interest in machine perfusion and oxygenation in pancreas <br />preservation for pancreas transplantation and islet preparation. [less ▲]

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See detailCouverture de pertes de substance du tibia distal par lambeau pedicule perforant en helice : deux cas cliniques.
Bous, Aurélie ULg; Ronsmans, C.; NIZET, Jean-Luc ULg et al

in Annales de Chirurgie Plastique Esthetique (2011)

Distal lower leg soft tissue defect is frequently a challenge to repair, particularly on the tibial crest. The coverage of this kind of lesion has some limitations because of regional minimal blood supply ... [more ▼]

Distal lower leg soft tissue defect is frequently a challenge to repair, particularly on the tibial crest. The coverage of this kind of lesion has some limitations because of regional minimal blood supply and paucity of local soft-tissue flaps. The perforator pedicled propeller (PPP) method tries to find a new place in lower leg reconstruction in bringing similar tissues at the recipient site and avoiding long and difficult free flap transfer or muscular sacrifice. The authors report on the use of PPP method for a tibial crest exposure after trauma and for a soft tissue defect with osteomyelitis on the tibial crest. [less ▲]

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See detailProfil des vendeurs de viande de chasse et évaluation de la biomasse commercialisée dans les marchés municipaux de Brazzaville, Congo.
Mbete, Roger Albert; Banga-Mboko, Henri; Ngokaka, Christophe et al

in Tropical Conservation Science (2011), 4(2), 203-217

The consumption of wildlife meat is an important source of animal protein for rural and urban population in Congo. A survey on bushmeat trade was undertaken in 21 municipal markets during four weeks, in ... [more ▼]

The consumption of wildlife meat is an important source of animal protein for rural and urban population in Congo. A survey on bushmeat trade was undertaken in 21 municipal markets during four weeks, in Brazzaville. The objective of this study was to define the traders’ profile and to evaluate the quantities of games and meat merchandised on the municipal markets. The study methodology combined two approaches: a quantitative one using a questionnaire as principal tool for collecting data, and a qualitative one associating informal survey methods via individual or group interviews. The results showed that women were the most involved in this trade (52%). Markets trader’s monthly income was estimated at 210,428 (US$420) ± 49,128 (US$98,256) FCFA. On average, the bushmeat traders’ were 39 ± 10 years old and 69% of them attended the two levels of secondary education. During four weeks, 3,711 animal carcasses were recorded on the 21 surveyed markets, representing almost 35,790 kg of biomass. Overall, 35 animal species were identified, including 9 the hunting of which was prohibited. The mammals constituted 93.8% of total number of hunted animals, with three dominant orders as the artiodactyls (49.2%), the rodents (22.6%) and the primates (17.7%), of which the Cephalophus, the Potamochoerus, the Atherurus and the Cercopithecus were the most represented. It was also noticed that trapping, an activity which leads to great losses, becomes very important, followed by be helpful alternatives to meet Congolese demand for bushmeat. For a sustainable management of the Congo’s faunic resources, this study suggests the introduction gun-hunting. The Congo-Ocean Railway and the National Road n°2 were used regularly in the transportation of game, to a 72% level. The district of Niari, Lekoumou, Sangha and Pool were the main sources of supply. At the present time, the meat quantities offered in Brazzaville markets don’t seem to be reduced because hunting areas extend always further, often to the detriment of protected areas. Despite the fact that such business squarely growths and shows evidence of overexploitation, activities promoting game farming and breeding of domestic species, in Brazzaville suburbs, are needed to mitigate the impact of bushmeat trade. [less ▲]

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See detailRés. CE 212.819, Smolcic - 212.989, Vanderlinden - 212.991, Fernandez-Grandjean
Delnoy, Michel ULg

in Aménagement - Environnement (2011), 4

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See detailRelationship between bone mineral density changes and risk of fractures among patients receiving calcium with or without vitamin D supplementation: a meta-regression
Rabenda, Véronique ULg; Bruyère, Olivier ULg; Reginster, Jean-Yves ULg

in Osteoporosis International (2011), 22

Surrogate measures of fracture risk, such as effects on bone mineral density, may be of great interest to assess the efficacy of available osteoporosis treatments. Our results suggest that bone mineral ... [more ▼]

Surrogate measures of fracture risk, such as effects on bone mineral density, may be of great interest to assess the efficacy of available osteoporosis treatments. Our results suggest that bone mineral density (BMD) changes cannot be used as a surrogate of anti-fracture efficacy, among patients receiving calcium, with or without vitamin D. Introduction: The purpose of this study is to examine the association between changes in bone mineral density with reduction in the risk of fractures in patients receiving calcium with or without vitamin D. Methods: We selected all randomized placebo-controlled clinical trials of calcium with or without vitamin D supplementation. To be included in this analysis, the studies were required to report both BMD (hip/proximal femur and/or lumbar spine) and the incidence of fractures. Metaregression analyses were used to examine the associations of changes in BMD with reduction in risk of fracture over the duration of each study. The change in BMD was the difference between changes (from baseline) observed in the active treatment group and placebo group. Results: A total of 15 randomized trials (n=47,365) were identified, most of whom (77%) came from the Women’s Health Initiative trial. Results show that larger increases in BMD at the lumbar spine were not associated with greater reduction in fracture risk. Concerning hip BMD changes, we found a statistically significant relationship between hip BMD changes and reduction in risk. However, results were not quite significant after excluding the both largest studies, in which BMD changes were measured in very small subset of patients. These points may have largely biased our results. Conclusions: In conclusion, there was no evidence of a relationship between BMD changes and reduction in risk of fractures among patients receiving calcium with or without vitamin D supplementation. Calcium and/or Vitamin D may reduce fracture rates through a mechanism independent of bone density. [less ▲]

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See detailLeibniz et la question du possible
Bouquiaux, Laurence ULg

in À l'émergence de la modernité : Histoire des idées au XVIIe siècle (2011)

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See detailDe la nature et des mains jaillit l'étonnement...
Eloy, Céline ULg

in Flux News (2011), 54

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See detailPlasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change.
Jakobsen, Marianne U.; Dethlefsen, Claus; Due, Karen M. et al

in Obesity facts (2011), 4(4), 312-8

OBJECTIVE: We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change ... [more ▼]

OBJECTIVE: We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers. METHOD: A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression. RESULTS: The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight change was -0.7 g per 1% point higher long-chain n-3 PUFA level (95% confidence interval: -20.7 to 19.3). The results when stratified by sex, age, or BMI groups were not systematically different. CONCLUSION: The results of this study suggest that the proportion of long-chain n-3 PUFA in plasma phospholipids is not associated with subsequent change in body weight within the range of exposure in the general population. [less ▲]

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See detailRelation entre défaillances vitales précédant l'infection acquise aux soins intensifs et gravité de celle-ci
MARECHAL, Hugues; LEDOUX, Didier ULg; NYS, Monique ULg et al

in Réanimation (2011), 20(Suppl 1), 108102

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