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See detailDu droit à l'enfant au travail psychique de la parentalité: approche psychanalytique de la maternité lesbienne
Naziri, Despina ULg

in Cliniques Méditerranéennes (2011), (83 (1)), 109-124

This article presents the first hypotheses and questions developped from a clinical study in the representation of the parental function by lesbian couples asking for Artificial Insemination by Donor (AID ... [more ▼]

This article presents the first hypotheses and questions developped from a clinical study in the representation of the parental function by lesbian couples asking for Artificial Insemination by Donor (AID). The early French speaking and English speaking reference on the debate on same sex parenthood within the psychoanalytical communities led us to structure our qualitative data analysis (case analysis of thirty two couples around two main issues. First, AID can be seen as an experience which introduces a third person to the lesbian couple and carries an important paradox for the psyche ol all those involved; secondly, it is useful to analyse the psychic developments linkec to access to same sex parenthood, and in particular how subjects construe themselves as biological or social mothers. This two-pronged analysis based on clinical cases actually serves a metapsychological reflection on the concept of psychic bisexuality. as a key element of psychic development for lesbian couples. [less ▲]

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See detailDioxin2011 Highlights
Focant, Jean-François ULg

Report (2011)

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See detailTravailler moins pour travailler plus longtemps
Cremer, Helmuth; Dedonder, Philippe; Maldonado, Dario et al

in Annales d’Economie et de Statistique = Annals of Economics and Statistics (2011), 2(101/102), 257-270

Nous développons un modèle dans lequel les travailleurs peuvent avoir tendance à trop travailler quand ils sont jeunes, parce qu’ils ne peuvent ou ne veulent pas voir les conséquences que cela peut avoir ... [more ▼]

Nous développons un modèle dans lequel les travailleurs peuvent avoir tendance à trop travailler quand ils sont jeunes, parce qu’ils ne peuvent ou ne veulent pas voir les conséquences que cela peut avoir sur leur santé et sur leur capacité à travailler longtemps. Pour les obliger à mieux répartir leurs efforts sur leur cycle de vie, une taxe sur les revenus du travail en début de vie et une subvention de l’épargne sont souhaitables. Si la subvention de l’épargne n’est pas disponible, la taxe optimale arbitre entre quatre considérations différentes. Nous étudions également la taxe optimale quand les individus diffèrent en productivité. [less ▲]

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See detailObservations
Lecocq, Pascale ULg

in Journal des Juges de Paix = Tijdschrift van de Vrederecters (2011)

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See detailPrincipaux modèles utilisés en régression logistique
Gillet, Adeline; Brostaux, Yves ULg; Palm, Rodolphe ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2011), 15(3), 425-433

Regression is a commonly used technique for describing the relationship between a response variable and one or more explanatory variables. When the response variable is a categorical variable, usual ... [more ▼]

Regression is a commonly used technique for describing the relationship between a response variable and one or more explanatory variables. When the response variable is a categorical variable, usual regression based on ordinary least squares should be replaced by logistic regression. Binary logistic regression should be used to perform a regression on a dichotomous response. Nominal polytomous logistic regression applies to a categorical response variable that has more than two levels with a natural ordering. And ordinal polytomous logistic regression is used when the response is a categorical variable that has more than two levels with a natural ordering. This note gives an overview of these logistic regression methods and describes three models commonly used when performing ordinal logistic regression. These models are illustrated by an example related to oak decline in the Walloon Region (Belgium). [less ▲]

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See detailA hybrid bioregulatory model of angiogenesis during bone fracture healing
Peiffer, Veronique; Gerisch, Alf; Vandepitte, Dirk et al

in Biomechanics & Modeling in Mechanobiology (2011), 10(3), 383-395

Bone fracture healing is a complex process in which angiogenesis or the development of a blood vessel net work plays a crucial role. In this paper, a mathematicalmodel is presented that simulates the ... [more ▼]

Bone fracture healing is a complex process in which angiogenesis or the development of a blood vessel net work plays a crucial role. In this paper, a mathematicalmodel is presented that simulates the biological aspects of fracture healing including the formation of individual blood vessels. The model consists of partial differential equations, several of which describe the evolution in density of the most important cell types, growth factors, tissues and nutrients. The other equations determine the growth of blood vessels as a result of themovement of leading endothelial (tip) cells. Branching and anastomoses are accounted for in the model. The model is applied to a normal fracture healing case and subjected to a sensitivity analysis. The spatiotemporal evolution of soft tissues and bone, as well as the development of a blood vessel network are corroborated by comparison with experimental data. Moreover, this study shows that the proposed mathematical framework can be a useful tool in the research of impaired healing and the design of treatment strategies. [less ▲]

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See detailJean-Marie Klinkenberg : Un homme d'(inter)action
Sindaco, Sarah ULg

in Français & Société (2011), (hors-série), 52

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See detailDevelopment and validation of a ultra-high-performance liquid chromatography-UV method for the detection and quantification of erectile dysfunction drugs and some of their analogues found in counterfeit medicines
Sacré, Pierre-Yves ULg; Deconinck, Eric; Chiap, Patrice ULg et al

in Journal of Chromatography. A (2011), 1218

Pharmaceutical counterfeiting is a permanently growing problem. Control laboratories are constantly analysing counterfeit medicines. In industrialised countries, one of the main counterfeited class of ... [more ▼]

Pharmaceutical counterfeiting is a permanently growing problem. Control laboratories are constantly analysing counterfeit medicines. In industrialised countries, one of the main counterfeited class of medicines are erectile dysfunction drugs. This paper describes the development and validation of a fast method to detect and quantify the three authorised phosphodiesterase type 5 inhibitors and five analogues. The method is based on the use of a sub-2 microns polar-embedded column with a gradient using acetonitrile as organic modifier and 10 mM ammonium formate buffer (pH 3.5) as aqueous component of the mobile phase. The separation was achieved in less than 4.5 min. The method has also been compared to the registered HPLC method for the assay of Viagra® which was considered as the reference method. The method is also compatible with on-line coupling mass spectrometry and will significantly reduce analysis times and solvent consumption. [less ▲]

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See detailElectron-deficient 1- and 2-aza-1,3-dienes: a comprehensive survey of their synthesis and reactivity
Monbaliu, Jean-Christophe ULg; Masschelein, Kurt; Stevens, Christian

in Chemical Society Reviews (2011), 40

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See detailDirect nano-in-micropatterning of TiO2 thin layers and TiO2/Pt nanoelectrode arrays by deep X-ray lithography
Faustini, M.; Marmiroli, B.; Malfatti, L. et al

in Journal of Materials Chemistry (2011), 21

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See detailFamiliarité spatiale dans deux communes périurbaines belges
Dubois, Charline ULg; Schmitz, Serge ULg

in Cahiers de Géographie du Quebec (2011), 55(154), 51-65

Analysing spatial familiarity aims to measure how places included in the life-world and in the cognitive map are familiar. Based on the study of Gale, Golledge, Halperin & Couclelis (1990), this paper ... [more ▼]

Analysing spatial familiarity aims to measure how places included in the life-world and in the cognitive map are familiar. Based on the study of Gale, Golledge, Halperin & Couclelis (1990), this paper explores the spatial familiarity of the inhabitants of two municipalities at the fringe of Liege (Belgium): it questions the links between the cognitive dimensions (visual, nominal, localisation) and themselves and the behavioural dimension (passing). It seeks new relevant places for the population of these urban fringe as well as the favourable factors to a good familiarity of a place. Finally, it scrutinizes the influence of people's mobility – period of residence, commuting to work, modes of transport – on spatial familiarity. [less ▲]

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See detailMathematical modeling of cell-cell and cell-matrix adhesion in tissue engineering using continuum models
Geris, Liesbet ULg; Gerisch, A.

in Geffen, A. (Ed.) Cellular and Biomolecular Mechanics and Mechanobiology (2011)

Key factors in the formation of cell aggregates in tissue engineering and other fields are the cell-cell and cell-matrix interactions. Other important factors are culture conditions such as nutrient and ... [more ▼]

Key factors in the formation of cell aggregates in tissue engineering and other fields are the cell-cell and cell-matrix interactions. Other important factors are culture conditions such as nutrient and oxygen supply and the characteristics of the environment (medium versus hydrogel). As mathematical models are increasingly used to investigate biological phenomena, it is important that processes such as cell adhesion are adequately described in the models. Recently a technique was developed to incorporate cell-cell and cell-matrix adhesion in continuum models through the use of non-local terms. In this study we apply this technique to model adhesion in a cell-in-gel culture set-up often found in tissue engineering applications. We briefly describe the biological issues underlying this study and the various modeling techniques used to capture adhesive behaviour. We furthermore elaborate on the numerical techniques that were developed in the course of this study. Finally, we consider a tissue engineering model that describes the spatiotemporal evolution of the concentration of cells, matrix, hydrogel, matrix degrading enzymes and oxygen/nutrients in a cell-in-gel culture system. Sensitivity analyses indicate a clear influence of the different adhesive processes on the final cell and collagen density and distribution, demonstrating the significance of cell adhesion in tissue engineering and the potential of the proposed mathematical technique. [less ▲]

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See detailModelling the hydrological response of an urban watershed Diachronic analysis of the effects of land use changes on storm runoff generation in the Upper Bukit Timah basin, Singapore
Cesar, Emilie ULg

Master's dissertation (2011)

This work consisted in the modelling of the rainfall-runoff relationships in the Upper Bukit Timah catchment in Singapore, in order to highlight the impacts of urbanisation on hydrology. The SWMM model, a ... [more ▼]

This work consisted in the modelling of the rainfall-runoff relationships in the Upper Bukit Timah catchment in Singapore, in order to highlight the impacts of urbanisation on hydrology. The SWMM model, a one-dimensional physically based model especially developed for urban areas, was mainly used. The parameters encoded into the model were determined by different means and several methods were used for their determination in order to assess their influence on the modelling.Using the final adjustment of the SWMM model, a diachronic analysis was performed in order to present the effects of urbanisation on runoff. [less ▲]

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See detailEnhanced Activity of Meprin-a, a Pro-Migratory and Pro-Angiogenic Protease, in Colorectal Cancer
Lottaz, Daniel; Maurer, Christoph A; Noël, Agnès ULg et al

in PLoS ONE (2011), 6(11), 26450

Meprin-α is a metalloprotease overexpressed in cancer cells, leading to the accumulation of this protease in a subset of colorectal tumors. The impact of increased meprin-α levels on tumor progression is ... [more ▼]

Meprin-α is a metalloprotease overexpressed in cancer cells, leading to the accumulation of this protease in a subset of colorectal tumors. The impact of increased meprin-α levels on tumor progression is not known. We investigated the effect of this protease on cell migration and angiogenesis in vitro and studied the expression of meprin-α mRNA, protein and proteolytic activity in primary tumors at progressive stages and in liver metastases of patients with colorectal cancer, as well as inhibitory activity towards meprin-α in sera of cancer patient as compared to healthy controls. We found that the hepatocyte growth factor (HGF)- induced migratory response of meprin-transfected epithelial cells was increased compared to wild-type cells in the presence of plasminogen, and that the angiogenic response in organ-cultured rat aortic explants was enhanced in the presence of exogenous human meprin-α. In patients, meprin-α mRNA was expressed in colonic adenomas, primary tumors UICC (International Union Against Cancer) stage I, II, III and IV, as well as in liver metastases. In contrast, the corresponding protein accumulated only in primary tumors and liver metastases, but not in adenomas. However, liver metastases lacked meprin-α activity despite increased expression of the corresponding protein, which correlated with inefficient zymogen activation. Sera from cancer patients exhibited reduced meprin-α inhibition compared to healthy controls. In conclusion, meprin-α activity is regulated differently in primary tumors and metastases, leading to high proteolytic activity in primary tumors and low activity in liver metastases. By virtue of its pro-migratory and pro-angiogenic activity, meprin-α may promote tumor progression in colorectal cancer. [less ▲]

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See detailInterpretations of Polar Bear (Ursus maritimus) Tracks by Inuit Hunters: Inter-rater Reliability and Inferences Concerning Accuracy
Wong, Pamela; Van Coeverden de Groot, Peter; Fekken, Cynthia et al

in Canadian Field-Naturalist (2011), 125(2), 140-153

due to their tracking experience in pursuing Polar Bears (Ursus maritimus), Inuit hunters could provide non-invasive estimates of Polar Bear characteristics from tracks, and Polar Bear monitoring programs ... [more ▼]

due to their tracking experience in pursuing Polar Bears (Ursus maritimus), Inuit hunters could provide non-invasive estimates of Polar Bear characteristics from tracks, and Polar Bear monitoring programs could benefit from Inuit input. We determined i) inter-rater reliability of estimates of the sex, age, and size of Polar Bears, and estimates of the age of tracks made by a group of nine Inuit hunters who interpreted 78 tracks; ii) we made preliminary comparisons of sex and size estimates with conventional (scientific) estimates; iii) we catalogued the Polar Bear hunting experience and track interpretation techniques of nine Inuit hunters; and iv) we explored relationships between hunting experience and the ability to interpret tracks. The group of Inuit hunters made reliable and consistent estimates of Polar Bear sex, age, and size, as well as estimates of age of track (after data from one participant was excluded). Although our comparisons are based on small samples, our findings suggest that Inuit hunters may be accurate in estimating the sex of Polar Bears (74.42% agreement with genetic determinations) and the size of Polar Bears from their tracks. our data indicate shared tracking techniques used by hunters may explain high agreement in making specific estimates, while individual hunting experience and particular methods used to interpret tracks may lead to inter-rater reliability and accuracy in interpreting tracks. [less ▲]

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See detailFunctional analysis of hydrogen photoproduction in respiratory-deficient mutants of Chlamydomonas reinhardtii
Lecler, Renaud ULg; Godaux, Damien ULg; Vigeolas, Hélène ULg et al

in International Journal of Hydrogen Energy (2011), 36

In this paper, mitochondrial mutants of Chlamydomonas reinhardtii defective for respiratory complex I (NADH:ubiquinone oxidoreductase), complex III (ubiquinol cytochrome c oxidoreductase) and both ... [more ▼]

In this paper, mitochondrial mutants of Chlamydomonas reinhardtii defective for respiratory complex I (NADH:ubiquinone oxidoreductase), complex III (ubiquinol cytochrome c oxidoreductase) and both complexes I and III were analyzed for H2 photoproduction. Several parameters were followed during the S-deficiency stage and the anaerobic stage leading to H2 photoproduction. At the early aerobic S-deficiency stage, starch and neutral lipids accumulated in all strains but their amount was significantly decreased in mutants compared to wild type. During the H2 photoproduction process, whereas starch content strongly decreased in all strains, neutral lipid amount remained nearly unchanged, suggesting that starch degraded by glycolysis is the preferential substrate for energy production during anaerobiosis. The mutants displayed a decrease in H2 photoproduction correlating to the number of active mitochondrial proton-pumping sites lost in the strains. Our results thus highlight the critical role of oxidative phosphorylation during the first (aerobic) stage of S-starvation when carbon resources are accumulated. [less ▲]

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See detailInvestigating the performance of model order reduction techniques for nonlinear radiative heat transfer problems
Hickey, D.; Masset, Luc ULg; Kerschen, Gaëtan ULg et al

in Proceedings of the International Conference on Advanced Computational Methods in Engineering (2011)

The problem of nonlinear radiative heat transfer is one of great importance to the aerospace industry. However, analysing large-scale, nonlinear, multiphysical, dynamical structures, by using mathematical ... [more ▼]

The problem of nonlinear radiative heat transfer is one of great importance to the aerospace industry. However, analysing large-scale, nonlinear, multiphysical, dynamical structures, by using mathematical modelling and simulation, e.g. Finite Element Modelling (FEM), can be computationally expensive. This provides motivation for the development of Model-Order Reduction (MOR) techniques capable of reducing simulation times without the loss of important information. The objective is to demonstrate the method of Proper Orthogonal Decompostition (POD) as a technique for nonlinear MOR. The nonlinear radiative exchanges between a linear benchmark beam within an external box (Figure 1) are analysed and a reduction procedure for this fully coupled, nonlinear, multiphysical, thermomechanical system is established. The solution to the strongly coupled, thermomechanical equations of motion is found by making use of an extended version of the implicit generalized-alpha scheme. In the reduced model, the residual of the unreduced system of equations need to be evaluated at each Newton iteration of each time step. In order to optimise the efficiency of the reduction method it is shown that the internal forces can be split into their linear and nonlinear counterparts. Only the nonlinear terms change at each time step, thus only these terms need to remain in the iterative loop significantly reducing the number of parameters that are to be computed at each step. These efficiency improvements to the method are discussed and the results are given. [less ▲]

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