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See detailLa main de Gilliatt-Sumner ou le syndrome de défilé cervicothoracique neurogène vrai. A propos de sept cas opérés.
DUBUISSON, Annie ULg; NGUYEN KHAC, Minh-Tuan ULg; SCHOLTES, Félix ULg et al

in Neuro-Chirurgie (2011), 57(1), 9-14

BACKGROUND AND PURPOSE: The clinical picture of hand atrophy related to a cervical rib or elongated C7 transverse process was well described in the modern literature by Gilliatt and Sumner; in 1970, they ... [more ▼]

BACKGROUND AND PURPOSE: The clinical picture of hand atrophy related to a cervical rib or elongated C7 transverse process was well described in the modern literature by Gilliatt and Sumner; in 1970, they reported a series of nine patients whose motor status was stabilized following brachial plexus decompression. We report here seven patients suffering from thoracic outlet syndrome (TOS), who developed hand atrophy, sometimes because of diagnostic delay. METHODS: The patient's charts were analysed retrospectively. RESULTS: The seven patients were all female; the mean age was 43 years. The first complaints were arm pain and paresthesias lasting six months to 5 years. Three patients were treated with C56/C67 discectomy plus disc prosthesis (one patient), ulnar neurolysis at the elbow (the same patient), carpal tunnel release (one patient), and intravenous immunoglobulins (one patient) before TOS diagnosis. Hand atrophy, severe in five patients, was present at presentation. All patients underwent brachial plexus decompression by the anterior (four), posterior (two), or transaxillary (one) approach. This last approach was completed 18 months later by brachial plexus neurolysis via the anterior approach. Postoperatively, motor deficit was improved in two patients and stabilized in five patients. CONCLUSIONS: Physicians' unfamiliarity with TOS diagnosis or their reluctance to accept the diagnosis without electrical confirmation can lead to hand atrophy. Brachial plexus decompression at this stage usually stabilizes the deficit. [less ▲]

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See detailApport au patrimoine commun et avance sur part de communauté: deux modalités originales. Note sous Liège, 7 septembre 2010
Rousseau, Laura ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2011)

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See detailCubeSat Activities at the University of Liège
Denis, Amandine ULg; Pisane, Jonathan ULg; Verly, Jacques ULg et al

Conference (2011)

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See detailSpecific interactions of mycosubtilin with cholesterol-containing artifical membranes
Nasir, Mehmet Nail ULg; Besson, Françoise

in Langmuir (2011), 27

Mycosubtilin is a natural antimicrobial lipopeptide produced by Bacillus subtilis strains. It is characterized by its hemolytic and strong antifungal activities. Mycosubtilin interacts with the plasma ... [more ▼]

Mycosubtilin is a natural antimicrobial lipopeptide produced by Bacillus subtilis strains. It is characterized by its hemolytic and strong antifungal activities. Mycosubtilin interacts with the plasma membranes of sensitive cells. However, the molecular mechanisms of its biological activities have not been completely elucidated. Our purpose was therefore to analyze the interactions of mycosubtilin with biological membranes by using biomimetic membranes such as Langmuir monolayers and multilayers. Structural changes of mycosubtilin, involving its peptide backbone and the side chain of its tyrosyl residue, were observed when the lipopeptide was interacting with cholesterol-containing multilayers. The interactions of mycosubtilin with monolayers constituted by pure lipids and by phosholipid/cholesterol or phospholipid/sphingomyelin/cholesterol were also examined. An original behavior of mycosubtilin toward cholesterol-containing monolayers was found. However, this original behavior was lost when mycosubtilin was interacting with pure cholesterylacetate monolayers. This suggests the involvement of the alcohol group of cholesterol in mycosubtilin-cholesterol interactions within membranes. Moreover, mycosubtilin induced changes in the organization and morphology of cholesterol-containing monolayers, and large condensed domains with different levels of condensation appeared only in the case of DPPC/sphingomyelin/cholesterol monolayer. [less ▲]

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See detailOutcome of pregnancy in women with inflammatory bowel disease treated with antitumor necrosis factor therapy.
Schnitzler, François ULg; Fidder, Herma; Boukerroucha, Meriem ULg et al

in Inflammatory Bowel Diseases (2011), 17(9), 1846-1854

BACKGROUND:: Infliximab (IFX) and adalimumab (ADA) are attractive treatment options in patients with inflammatory bowel disease (IBD) also during pregnancy but there is still limited data on the benefit ... [more ▼]

BACKGROUND:: Infliximab (IFX) and adalimumab (ADA) are attractive treatment options in patients with inflammatory bowel disease (IBD) also during pregnancy but there is still limited data on the benefit/risk profile of IFX and ADA during pregnancy. METHODS:: This observational study assessed pregnancy outcomes in 212 women with IBD under antitumor necrosis factor alpha (TNF) treatment at our IBD unit. Pregnancy outcomes in 42 pregnancies with direct exposure to anti-TNF treatment (35 IFX, 7 ADA) were compared with that in 23 pregnancies prior to IBD diagnosis, 78 pregnancies before start of IFX, 53 pregnancies with indirect exposure to IFX, and 56 matched pregnancies in healthy women. RESULTS:: Thirty-two of the 42 pregnancies ended in live births with a median gestational age of 38 weeks (interquartile range [IQR] 37-39). There were seven premature deliveries, six children had low birth weight, and there was one stillbirth. One boy weighed 1640 g delivered at week 33, died at age of 13 days because of necrotizing enterocolitis. A total of eight abortions (one patient wish) occurred in seven women. Trisomy 18 was diagnosed in one fetus of a mother with CD at age 37 under ADA treatment (40 mg weekly) and pregnancy was terminated. Pregnancy outcomes after direct exposure to anti-TNF treatment were not different from those in pregnancies before anti-TNF treatment or with indirect exposure to anti-TNF treatment but outcomes were worse than in pregnancies before IBD diagnosis. CONCLUSIONS:: Direct exposure to anti-TNF treatment during pregnancy was not related to a higher incidence of adverse pregnancy outcomes than IBD overall. (Inflamm Bowel Dis 2011;). [less ▲]

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See detailVariable Neighborhood Search applied to the Vehicle Routing Problem
François, Véronique ULg

Learning material (2011)

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See detailDeforestation in Central and West Africa: landscape dynamics, anthropogenic effects and ecological consequences.
Barima, Y S S; Djibu, J P; Alongo, S et al

in Daniels, J A (Ed.) Advances in Environmental Research - Volume 7 (2011)

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See detailBRYOPHYTES DU PARC NATIONAL DU MERCANTOUR : METHODES ET RESULTATS DE LA CAMPAGNE D'INVENTAIRES 2010 ATBI+M
Saatkamp, Arne; Aleffi, Michele; de Biaggi, Marta et al

in Biocosme Mesogeen (2011), 28(2), 23-50

During the All Taxa Biodiversity Inventory + Monitoring programme (ATBI+M) in the Mercantour and Alpi Marittime National Parks, our inventories of bryophytes identified 234 taxa (mosses and liverworts ... [more ▼]

During the All Taxa Biodiversity Inventory + Monitoring programme (ATBI+M) in the Mercantour and Alpi Marittime National Parks, our inventories of bryophytes identified 234 taxa (mosses and liverworts). This work completes the previous field campaigns, notably those of Jean-Pierre Hebrard (I MEP, Marseille) since 1965, and the ATBI bryophyte inventories in 2007. This number is based on four days of inventories in the central and peripheric territory of both National Parks, in four days in July and August 2010, together with previous data the 565 taxa known from the area still underestimate the number of species actually present. Our observations in 2010 added several new species for this area, including several rare and remarkable species such as Haplomitrium hookeri or species listed under the Habitats Directive as Buxbaumia viridis and Orthotrichum rogeri. Given the rarity of their habitats species from snow beds, large block boulders and high altitude wetlands are most remarkable. [less ▲]

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See detailTropical forest carbon stocks estimates. Is tree aboveground biomass variability at the landscape scale really non-significant in a REDD+ context?
Bastin, Jean-François ULg; Bogaert, Jan ULg; De Cannière, C

in Research Priorities in Tropical Silviculture: Towards New Paradigms? (2011)

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See detailOnderneming en recht. Bedrijfsfiscaliteit
Peeters, Bart ULg

Book published by Knops Publishing (2011)

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See detailNanobodies as structural probes to investigate the mechanism of fibril formation by the amyloidogenic variants of human lysozyme
Dumont, Janice ULg; Pardon, Els; Aumont-Nicaise, Magalie et al

Poster (2011)

Six variants of human lysozyme (single-point mutations I56T, F57I, W64R, D67H and double mutations F57I/T70N, W112R/T70N) are associated with a hereditary non-neuropathic systemic amyloidose. These ... [more ▼]

Six variants of human lysozyme (single-point mutations I56T, F57I, W64R, D67H and double mutations F57I/T70N, W112R/T70N) are associated with a hereditary non-neuropathic systemic amyloidose. These proteins form extracellular amyloid fibrils that deposit in a wide range of tissues and organs such as liver, spleen and kidneys where they cause damages [1]. It was shown that the D67H and I56T mutations cause a loss in stability and more particularly a loss of global cooperativity of protein [1]. Consequently, under physiologically relevant conditions, these variants can transiently populate a partially unfolded state in which the beta-domain and the C-helix are cooperatively unfolded while the rest of the protein remains native like [1]. The formation of intermolecular interactions between the regions that are unfolded in this intermediate state is likely to be a fundamental trigger of the aggregation process that ultimately leads to the formation and deposition of fibrils in tissues. We have also shown that the binding of three variable domain of camelid antibodies or (VHHs) - raised against the wild type human lysozyme inhibit in vitro the formation of amyloid fibrils by the lysozyme variants. These three VHHs bind on different regions of lysozyme and act as amyloid fibrils inhibitor through different mechanisms [2, 3, and unpublished results]. In the present work, sixteen new VHHs specific of human lysozyme have been generated. Competition experiments have shown that they bind to five non overlapping epitopes. We have demonstrated that five of these new VHHs are able to bind lysozyme in conditions used for amyloid fibril formation, and interestingly two of them recognize two epitopes that are different from those of the three VHHs previously characterized [2, 3, and unpublished results]. The effects of these new VHHs on the properties of lysozyme variants such as activity, stability, cooperativity and aggregation will be discussed. [less ▲]

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See detailJatropha curcas in sub-saharian Africa: The big illusion ?
Mergeai, Guy ULg; Terren, Marieke ULg; Jacquet de Haveskercke, P. et al

Conference (2011)

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See detailDioxin2011 Highlights
Focant, Jean-François ULg

Report (2011)

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See detailTravailler moins pour travailler plus longtemps
Cremer, Helmuth; Dedonder, Philippe; Maldonado, Dario et al

in Annales d’Economie et de Statistique = Annals of Economics and Statistics (2011), 2(101/102), 257-270

Nous développons un modèle dans lequel les travailleurs peuvent avoir tendance à trop travailler quand ils sont jeunes, parce qu’ils ne peuvent ou ne veulent pas voir les conséquences que cela peut avoir ... [more ▼]

Nous développons un modèle dans lequel les travailleurs peuvent avoir tendance à trop travailler quand ils sont jeunes, parce qu’ils ne peuvent ou ne veulent pas voir les conséquences que cela peut avoir sur leur santé et sur leur capacité à travailler longtemps. Pour les obliger à mieux répartir leurs efforts sur leur cycle de vie, une taxe sur les revenus du travail en début de vie et une subvention de l’épargne sont souhaitables. Si la subvention de l’épargne n’est pas disponible, la taxe optimale arbitre entre quatre considérations différentes. Nous étudions également la taxe optimale quand les individus diffèrent en productivité. [less ▲]

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See detailComparison of the Full Outline of UnResponsiveness and Glasgow Liege Scale/Glasgow Coma Scale in an Intensive Care Unit Population.
Bruno, Marie-Aurélie ULg; LEDOUX, Didier ULg; LAMBERMONT, Bernard ULg et al

in Neurocritical Care (2011), 15(3), 447-53

BACKGROUND: The Full Outline of UnResponsiveness (FOUR) has been proposed as an alternative for the Glasgow Coma Scale (GCS)/Glasgow Liege Scale (GLS) in the evaluation of consciousness in severely brain ... [more ▼]

BACKGROUND: The Full Outline of UnResponsiveness (FOUR) has been proposed as an alternative for the Glasgow Coma Scale (GCS)/Glasgow Liege Scale (GLS) in the evaluation of consciousness in severely brain-damaged patients. We compared the FOUR and GLS/GCS in intensive care unit patients who were admitted in a comatose state. METHODS: FOUR and GLS evaluations were performed in randomized order in 176 acutely (<1 month) brain-damaged patients. GLS scores were transformed in GCS scores by removing the GLS brainstem component. Inter-rater agreement was assessed in 20% of the studied population (N = 35). A logistic regression analysis adjusted for age, and etiology was performed to assess the link between the studied scores and the outcome 3 months after injury (N = 136). RESULTS: GLS/GCS verbal component was scored 1 in 146 patients, among these 131 were intubated. We found that the inter-rater reliability was good for the FOUR score, the GLS/GCS. FOUR, GLS/GCS total scores predicted functional outcome with and without adjustment for age and etiology. 71 patients were considered as being in a vegetative/unresponsive state based on the GLS/GCS. The FOUR score identified 8 of these 71 patients as being minimally conscious given that these patients showed visual pursuit. CONCLUSIONS: The FOUR score is a valid tool with good inter-rater reliability that is comparable to the GLS/GCS in predicting outcome. It offers the advantage to be performable in intubated patients and to identify non-verbal signs of consciousness by assessing visual pursuit, and hence minimal signs of consciousness (11% in this study), not assessed by GLS/GCS scales. [less ▲]

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See detailPrincipaux modèles utilisés en régression logistique
Gillet, Adeline; Brostaux, Yves ULg; Palm, Rodolphe ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2011), 15(3), 425-433

Regression is a commonly used technique for describing the relationship between a response variable and one or more explanatory variables. When the response variable is a categorical variable, usual ... [more ▼]

Regression is a commonly used technique for describing the relationship between a response variable and one or more explanatory variables. When the response variable is a categorical variable, usual regression based on ordinary least squares should be replaced by logistic regression. Binary logistic regression should be used to perform a regression on a dichotomous response. Nominal polytomous logistic regression applies to a categorical response variable that has more than two levels with a natural ordering. And ordinal polytomous logistic regression is used when the response is a categorical variable that has more than two levels with a natural ordering. This note gives an overview of these logistic regression methods and describes three models commonly used when performing ordinal logistic regression. These models are illustrated by an example related to oak decline in the Walloon Region (Belgium). [less ▲]

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See detailDoes Tribolium brevicornis cuticular chemistry deter cannibalism and predation of pupae?
Alabi, Taoffic; Dean, Jennifer; Michaud, Jean-Pierre et al

in Journal of Insect Science [=JIS] (2011), 11

The cuticular hydrocarbons of insects are species-specific and often function as semiochemicals. The activity of Tribolium brevicornis cuticular hydrocarbons as feeding deterrents that ostensibly function ... [more ▼]

The cuticular hydrocarbons of insects are species-specific and often function as semiochemicals. The activity of Tribolium brevicornis cuticular hydrocarbons as feeding deterrents that ostensibly function to prevent pupal cannibalism and predation was evaluated. The cuticular hydrocarbons of T. brevicornis pupae were characterized and flour disk bioassays conducted with individual and combined extract components incorporated into artificial diets on which Tribolium adults fed for six days. Feeding by T. brevicornis and T. castaneum on flour disks containing cuticular extracts of T. brevicornis pupae resulted in reduced consumption and weight loss relative to feeding on control flour disks. In both cases, feeding deterrence indices exceeded 80% suggesting that T. brevicornis cuticular hydrocarbons could function to deter cannibalism and predation of pupae by larvae and adult beetles. Sixteen different cuticular hydrocarbons were identified in T. brevicornis pupal extracts. Eight of the commercially available linear alkanes were tested individually in feeding trials with eight Tribolium species. One compound (C28) significantly reduced the amount of food consumed by three species compared to control disks, whereas the compounds C25, C26, and C27elicited increased feeding in some species. Four other compounds had no effect on consumption for any species. When four hydrocarbon mixtures were tested for synergistic deterrence on T. brevicornis and T. castaneum, none significantly influenced consumption. Our results indicate that the cuticular chemistry of T. brevicornis pupae could serve to deter predation by conspecific and congeneric beetles. [less ▲]

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See detailTGFbeta-receptor-dependent angiostimulation through the hyperglycosylated isoform of human chorionic gonadotropin.
Berndt, Sarah; Detilleux, Julien; Blacher, Silvia et al

in Placenta (2011), 32(9), 44

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See detailIdentification expérimentale et recalage d'une structure au comportement élastodynamique non-linéaire
Hot, A.; Kerschen, Gaëtan ULg; Cogan, S. et al

in Actes du 20ème Congrès Francais de Mécanique (2011)

This paper studies of the COST-F3 beam experimental benchmark that exhibits a geometric non-linear behavior. The whole identification process, i.e. the non-linear behaviour detection, characterisation and ... [more ▼]

This paper studies of the COST-F3 beam experimental benchmark that exhibits a geometric non-linear behavior. The whole identification process, i.e. the non-linear behaviour detection, characterisation and the parameter estimation, is carried out using measured time and frequency responses. A finite element model is also built in order to update the non-linear parameter using the hybrid multi-harmonic balance extended constitutive relation error method. [less ▲]

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