Recent trends in specular light reflectance beyond clinical fluorescence diagnosis.
; Pierard, Sébastien ; PIERARD-FRANCHIMONT, Claudine et al
in European Journal of Dermatology (2011), 21(2), 157-61
Under specific light illumination, particularly ultraviolet (UV) and near-UV light stimulation, the skin produces both specular light reflectance and, possibly, specific fluorescent emission. These ... [more ▼]
Under specific light illumination, particularly ultraviolet (UV) and near-UV light stimulation, the skin produces both specular light reflectance and, possibly, specific fluorescent emission. These properties offer diagnostic clues and disclose some peculiar functions of the skin. A series of superficial infections (erythrasma, some tinea capitis types, tinea/pityriasis versicolor, dermatophytoses, etc.) and pilosebaceous follicles enriched in Propionibacterium spp show fluorescence. This latter characteristic is downgraded or lost while on some anti-acne treatments. A quenching effect of fluorescence is observed following the application of sunscreens. The (pre)neoplastic areas prepared for methylaminolevulinate photodynamic therapy (MAL-PDT) show reddish fluorescence following drug metabolisation producing porphyrins by the abnormal activated cells. Of note, when using a recording sensitive CCD camera instead of casual visual observation, skin fluorescence may be superimposed on the specular reflectance of the incident light. With the current technology, these situations are not distinguished with confidence. Any harsh and scaly lesion appears brighter following yellowish specular light reflectance. Stratum corneum samplings collected on clear self-adhesive discs or cyanoacrylate skin surface strippings are conveniently examined ex vivo, taking advantage of the same optical properties. [less ▲]Detailed reference viewed: 16 (0 ULg)
L'espace de jugement des compétences en arts de la scène. Analyse d'un dispositif d'insertion sur le marché du travail des comédiens
Brahy, Rachel ; Orianne, Jean-François
in Revue Française de Socio-économie [=RFSE] (2011), 7
This article analyses a public instrument designed for the professional integration of young theatre performers in Belgium’s French Community: the “casting-training internship” (stage audition-formation ... [more ▼]
This article analyses a public instrument designed for the professional integration of young theatre performers in Belgium’s French Community: the “casting-training internship” (stage audition-formation). Drawing on the theoretical framework of the economy of conventions and on some empirical data from inquiries conducted in France, the authors study the innovative dimension of this instrument which allows for a variety of competences evaluation conventions. They also identify two major constraints affecting the conditions of a balanced skills assessment. [less ▲]Detailed reference viewed: 43 (19 ULg)
Rapid increase in aggressive behavior precedes the decrease in brain aromatase activity during socially mediated sex change in Lythrypnus dalli.
; Balthazart, Jacques ; et al
in General and Comparative Endocrinology (2011), 170(1), 119-24
In the bluebanded goby, Lythrypnus dalli, removal of the male from a social group results in a rapid behavioral response where one female becomes dominant and changes sex to male. In a previous study ... [more ▼]
In the bluebanded goby, Lythrypnus dalli, removal of the male from a social group results in a rapid behavioral response where one female becomes dominant and changes sex to male. In a previous study, within hours of male removal, aromatase activity in the brain (bAA) of dominant females was almost 50% lower than that of control females from a group in which the male had not been removed. For those females that displayed increased aggressive behavior after the male was removed, the larger the increase in aggressive behavior, the greater the reduction in bAA. To investigate whether decreased bAA leads to increased aggression, the present study used a more rapid time course of behavioral profiling and bAA assay, looking within minutes of male removal from the group. There were no significant differences in bAA between control females (large females from groups with the male still present), females that doubled their aggressive behavior by 10 or 20 min after male removal, or females that did not double their aggressive behavior within 30 min after male removal. Further, individual variation in bAA and aggressive behavior were not correlated in these fish. Whole brain decreases in aromatase activity thus appear to follow, rather than precede, rapid increases in aggressive behavior, which provides one potential mechanism underlying the rapid increase in androgens that follows aggressive interactions in many vertebrate species. For fish species that change sex from female to male, this increase in androgens could subsequently facilitate sex change. [less ▲]Detailed reference viewed: 14 (3 ULg)
In vivo assessment of the virulence of five Salmonella enterica serotypes isolated from helmeted guinea fowl (Numida meleagris) in Benin
; ; et al
in International Research Journal of Microbiology [=IRJM] (2011), 2Detailed reference viewed: 8 (1 ULg)
Radiative parameters of Nb I excited states
; ; et al
in Monthly Notices of the Royal Astronomical Society (2011), 412
Hyperplasia-adenoma sequence in pituitary tumorigenesis related to aryl hydrocarbon receptor interacting protein gene mutation.
; ; et al
in Endocrine-Related Cancer (2011)
Mutations of the aryl hydrocarbon receptor interacting protein (AIP) gene are associated with pituitary adenomas that usually occur as familial isolated pituitary adenomas (FIPA). Detailed pathological ... [more ▼]
Mutations of the aryl hydrocarbon receptor interacting protein (AIP) gene are associated with pituitary adenomas that usually occur as familial isolated pituitary adenomas (FIPA). Detailed pathological and tumor genetic data on AIP mutation-related pituitary adenomas are scarce. Non-identical twin females presented as adolescents to the emergency department with severe progressive headaches caused by large pituitary macroadenomas requiring emergency neurosurgery; one patient had incipient pituitary apoplexy. Post-surgically the patients were found to have silent somatotrope adenomas on pathological examination. Furthermore, the light microscopic, immunohistochemical and electron microscopic studies demonstrated tumors of virtually identical characteristics. The adenomas were accompanied by multiple areas of pituitary hyperplasia, which stained positively for growth hormone, indicating somatotrope hyperplasia. Genetic analyses of the FIPA kindred revealed a novel E216X mutation of the AIP gene, which was present in both affected patients and the unaffected father. Molecular analysis of surgical specimens revealed loss of heterozygosity (LOH) in the adenoma, but showed that LOH was not present in the hyperplasic pituitary tissue from either patient. AIP immunostaining confirmed normal staining in the hyperplastic tissue and decreased staining in the adenoma in the tumors from both patients. These results demonstrate that patients with AIP germline mutation can present with clinically silent somatotroph pituitary adenomas. The finding of somatotrope hyperplasia unaccompanied by AIP LOH, suggests that LOH at the AIP locus may be a late event in the progression from hyperplastic to adenomatous tissue. [less ▲]Detailed reference viewed: 23 (5 ULg)
Spontaneous Revolution’ in Tunisia: Yearnings for Freedom, Justice, and Dignity
in The Institute Letter. Institute for Advanced Study (2011), (Spring), 1-9Detailed reference viewed: 8 (0 ULg)
Finite Element Computation of Nonlinear Normal Modes
Renson, Ludovic ; Deliège, Geoffrey ; Noels, Ludovic et al
in Fifth International Conference on Advanced COmputational Methods in ENgineering (2011)Detailed reference viewed: 33 (5 ULg)
Influence of one-line vegetation on the edge of the floodplain on velocity and boundary shear stress distributions in compound channel
; Peltier, Yann ; et al
in 34th IAHR Congr.: Balance and Uncertainty; Water in a Changing World (2011)Detailed reference viewed: 3 (0 ULg)
Sedimentology and magnetic susceptibility on a continuous Lower Givetian to Lower Famennian fore-reef succession (Sauerland, Germany) : A new example which reinforce the use of MS for long-distance correlations (Germany, Belgium and Moravia).
Pas, Damien ; Da Silva, Anne-Christine ; Boulvain, Frédéric et al
This study focuses on the continuous Givetian-Frasnian section of the abandoned Burgberg quarry (Messinghausen Anticline, northern margin of the Rhenish Mountains). The exposed section (102 m thick ... [more ▼]
This study focuses on the continuous Givetian-Frasnian section of the abandoned Burgberg quarry (Messinghausen Anticline, northern margin of the Rhenish Mountains). The exposed section (102 m thick) covers a well constraint stratigraphic interval starting at the base of the Givetian (Stritzke 1991;Aboussalam et al., 2003) and according to Stritzke (1991) and our new datations ending within the Lower Famennian. The Middle-Upper Devonian shelf-edge within the Rheinisches Schiefergebirge can be traced from the supposed position along the southern rim of the Dinant Syncline and the Eifel Synclines, northwards along a line connecting the southern margin of the Devonian reefal outcrops of Attendorn and Brilon (Krebs 1967, 1974). The depositional setting of the investigated section corresponds to complex slope and basinal environments where reworked material from the proximal Brilon platform (located to the north) and basin deposits coexist. Thus, this section allows to follow the evolution of the Givetian-Frasnian Brilon platform (e.g., Machel 1990; Stritze 1990, 1991) in a deeper setting. Petrographic analysis of more than 330 thin-sections leads to the identification of 7 microfacies which are integrated into a palaeoenvironmental model. Microfacies curve evolution shows two main trends. A shallowing upward trend ending within a typical proximal slope setting (dismantling of the platform) followed by a deepening upward trend which is characterized by several meter of pelagic mudstone within the upper part of the studied section. Magnetic susceptibility variations in sedimentary rocks, have commonly been interpreted as related to variations of detritic inputs through climatic or sea level changes (Crick et al., 1994). The magnetic susceptibility (MS) study of more than 330 samples from this long-time fore-reef carbonated succession is an opportunity to better constraint our sedimentological interpretations. To do so, we propose a comparison between general MS trends and some parameters such as microfacies and relative sea level fluctuations interpreted on the basis of the sedimentological study. The relatively long stratigraphic interval covered by the Burgberg section offers a good opportunity to compare our data with the time equivalent Devonian sections of the Ardennes (Belgium) and Moravian karst area (Czech Republic) (Boulvain et al., 2010). And thus to test the magnetic susceptibility tool for long-distance correlation between stratigraphically well constraint sections. [less ▲]Detailed reference viewed: 15 (5 ULg)
Microwave-assisted conversion of carbohydrates. State of the art and outlook.
Richel, Aurore ; Laurent, Pascal ; Wathelet, Bernard et al
in Comptes Rendus Chimie (2011), 14
The valorisation of carbohydrates arising from the hydrolysis of renewable feedstocks (i.e. lignocellulosic biomass) is nowadays an area of outmost interest. In this context, the implementation of fast ... [more ▼]
The valorisation of carbohydrates arising from the hydrolysis of renewable feedstocks (i.e. lignocellulosic biomass) is nowadays an area of outmost interest. In this context, the implementation of fast, expeditious and cost-effective methodologies for the modification of these naturally occurring compounds is becoming a prerequisite. In this sense, the application of microwaves has gained progressive attention in laboratories for making a range of high-added value sugars derivatives scaffolds. Advantages of microwaves are numerous and include enhancement of reaction rates and yields, combined to improved regio-, chemo- and anomeric selectivities. Summary: 1. Introduction 2. Chemical transformations of monosaccharides Regioselective hydroxyls protections/deprotections Derivatisation at the anomeric position Other derivatisations Microwave-assisted click chemistry Synergy between microwaves and heterogeneous catalysis Enzymatic modifications of monosaccharides 3. Effect of microwave heating on polysaccharides Hydrolysis and pretreatment of cellulose Derivatisation of cellulose 4. Scale-up of microwave-promoted reactions 5. Conclusions [less ▲]Detailed reference viewed: 78 (36 ULg)
Esophageal cancer surgery in patients older than 75: long term results.
HONORE, Charles ; Al-Azzeh, Ali ; GILSON, Nathalie et al
in Acta Chirurgica Belgica (2011), 111(1), 12-7
PURPOSE: The purpose of this study was to evaluate short and long term results after esophageal cancer resection in patients older than 75. METHODS: We retrospectively analyzed the database of esophageal ... [more ▼]
PURPOSE: The purpose of this study was to evaluate short and long term results after esophageal cancer resection in patients older than 75. METHODS: We retrospectively analyzed the database of esophageal cancer surgically treated in our department between January 2003 and December 2009 to identify patients older than 75. The preoperative, operative, postoperative and long term characteristics were analyzed. RESULTS: Among 137 patient, 23 were older than 75. The histological subtype was adenocarcinoma in 100%. The surgical techniques were a "Lewis-Santy" procedure in 43%, a trans-hiatal resection in 22%, a "Sweet" procedure in 13%, a stripping in 13% and a McKeown procedure in 9%. The in-hospital postoperative mortality was 13%. The in-hospital postoperative morbidity (Dindo-Clavien Grade >2, deceased patients included) was 26%. In univariate analysis, no statistically significant risk factor of morbidity was found. A Charlson Comorbidity Index >2 was, in univariate analysis, the sole risk factor of postoperative mortality (p = 0.0362). The mean hospital stay was 22 +/- 12 days. The median survival was 24.2 months. The 5-year overall survival was 39% and the 5-year disease free survival was 26%.57% of long-term deaths were not cancer related. CONCLUSION: Esophageal surgery performed in selected patients older than 75 has an acceptable morbidity and mortality but when a severe complication occurs, it leads to death in half of the cases. Surgery enables a long term survival benefit. This study confirmed our attitude of not considering age as a contra-indication for esophageal surgery but rather considering general status, self-reliance and associated comorbidities for patients' selection. [less ▲]Detailed reference viewed: 20 (0 ULg)
Avis des entraîneurs belges francophones sur leur formation. Approche quantitative
Theunissen, Catherine ; Cloes, Marc
in Spallanzani, Carlo; Goyette, Robert; Roy, Martin (Eds.) et al Mieux former pour agir dans une société en mouvement (2011)
L'origine de cette recherche est liée à une étude précédente (Theunissen, 2007) consacrée à la formation des entraîneurs en Communauté française de Belgique. Dans la première, une étude qualitative ... [more ▼]
L'origine de cette recherche est liée à une étude précédente (Theunissen, 2007) consacrée à la formation des entraîneurs en Communauté française de Belgique. Dans la première, une étude qualitative analysait l'avis d'entraîneurs débutants à propos de la formation dispensée au sein de leur fédération sportive. La présente étude consiste à travailler à une plus grande échelle fin d'obtenir une vision beucoup plus globale de la situation en interrogeant des entraîneurs de toutes disciplines et de tous niveaux confondus. [less ▲]Detailed reference viewed: 53 (12 ULg)
Detection of counterfeit Viagra® by Raman Microspectroscopy imaging and multivariate analysis.
Sacré, Pierre-Yves ; ; et al
in Journal of Pharmaceutical & Biomedical Analysis (2011), 56Detailed reference viewed: 31 (11 ULg)
Mutations in FKBP10 cause recessive osteogenesis imperfecta and bruck syndrome.
; ; et al
in Journal of Bone and Mineral Research (2011)
Osteogenesis imperfecta (OI) is a genetic disorder of connective tissue characterized by bone fragility and alteration in synthesis and post-translational modification of type I collagen. Autosomal ... [more ▼]
Osteogenesis imperfecta (OI) is a genetic disorder of connective tissue characterized by bone fragility and alteration in synthesis and post-translational modification of type I collagen. Autosomal dominant OI is caused by mutations in the genes (COL1A1 or COL1A2) encoding the chains of type I collagen. Bruck syndrome is a recessive disorder featuring congenital contractures in addition to bone fragility; Bruck syndrome type 2 is caused by mutations in PLOD2 encoding collagen lysyl hydroxylase, while Bruck Syndrome type 1 has been mapped to 17q12 but the gene has remained elusive so far. Recently, the molecular spectrum of OI has been expanded with the description of the basis of a unique post-translational modification of type I procollagen, i.e. 3-prolyl-hydroxylation. Three proteins, cartilage-associated protein (CRTAP), prolyl-3-hydroxylase-1 (P3H1, encoded by the LEPRE1 gene), and the prolyl cis-trans isomerase cyclophilin-B (PPIB) form a complex that is required for fibrillar collagen 3-prolyl-hydroxylation and mutations in each gene have been shown to cause recessive forms of OI. Since then, an additional putative collagen chaperone complex, composed of FKBP10 (also known as FKBP65) and SERPINH1 (also known as HSP47), has also been shown to be mutated in recessive OI. Here, we describe five families with OI-like bone fragility in association with congenital contractures who all had FKBP10 mutations. Given the previous mapping of Bruck syndrome type 1 to the chromosomal region containing FKBP10, we conclude that FKBP10 mutations are the cause of Bruck syndrome type 1. (c) 2010 American Society for Bone and Mineral Research. [less ▲]Detailed reference viewed: 23 (5 ULg)
Lower Devonian rhynchonellid brachiopods from the Ougarta area (western Sahara, Algeria)
; ; et al
in Bulletin of Geosciences (2011), 86(1), 71-90
The description and study of rhynchonellid brachiopods recently collected from the Lower Devonian of the Ougarta area in western Algerian Sahara permitted the revision of previously described and/or ... [more ▼]
The description and study of rhynchonellid brachiopods recently collected from the Lower Devonian of the Ougarta area in western Algerian Sahara permitted the revision of previously described and/or listed taxa, mainly from Morocco. Palaeobiogeographically, the nine identified taxa share many similarities with the rhynchonellid fauna of the Ibarmaghian Domain. Five of the nine identified taxa belong to three genera of the Family Nucinulidae Sartenaer, 2004. Three of these are new taxa, namely Nucinulus orbignyanus crassicostus subsp. nov., Cuninulus ougartaensis sp. nov. and Palinulus saharaensis sp. nov. The our remaining taxa are assigned (one of them questionably) to the genera Lanceomyonia, Stenorhynchia and Glossinulus of the families Hebetoechiidae, Trigonirhynchiidae, and Glossinotoechiidae, respectively. [less ▲]Detailed reference viewed: 49 (5 ULg)