References of "2011"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailContinuum-level modelling of cellular adhesion and matrix production in aggregates.
Geris, Liesbet ULg; Ashbourn, Joanna M A; Clarke, Tim

in Computer Methods in Biomechanics & Biomedical Engineering (2011), 14(5), 403-10

Key regulators in tissue-engineering processes such as cell culture and cellular organisation are the cell-cell and cell-matrix interactions. As mathematical models are increasingly applied to investigate ... [more ▼]

Key regulators in tissue-engineering processes such as cell culture and cellular organisation are the cell-cell and cell-matrix interactions. As mathematical models are increasingly applied to investigate biological phenomena in the biomedical field, it is important, for some applications, that these models incorporate an adequate description of cell adhesion. This study describes the development of a continuum model that represents a cell-in-gel culture system used in bone-tissue engineering, namely that of a cell aggregate embedded in a hydrogel. Cell adhesion is modelled through the use of non-local (integral) terms in the partial differential equations. The simulation results demonstrate that the effects of cell-cell and cell-matrix adhesion are particularly important for the survival and growth of the cell population and the production of extracellular matrix by the cells, concurring with experimental observations in the literature. [less ▲]

Detailed reference viewed: 13 (2 ULg)
Full Text
Peer Reviewed
See detailLa famille transnationale dans tous ses états
Razy, Elodie ULg; Baby-Collin, Virginie

in Autrepart : Revue de Sciences Sociales au Sud (2011), 57-58

Detailed reference viewed: 25 (13 ULg)
Full Text
Peer Reviewed
See detailA new benzotriazole-mediated stereoflexible gateway to hetero-2,5-diketopiperazines
Monbaliu, Jean-Christophe ULg; Hansen, Finn; Beagle, Lucas et al

in Chemistry : A European Journal (2011), 18

Detailed reference viewed: 12 (3 ULg)
Full Text
Peer Reviewed
See detailA coupled two-scale computational scheme for the failure of periodic quasi-brittle thin planar shells and its application to masonry
Mercatoris, Benoît ULg; Massart, T. J.

in International Journal for Numerical Methods in Engineering (2011), 85(9), 1177-1206

This paper presents a multi-scale framework for the failure of periodic quasi-brittle thin planar shells. The failure behavior of textured or periodic heterogeneous materials is strongly influenced by ... [more ▼]

This paper presents a multi-scale framework for the failure of periodic quasi-brittle thin planar shells. The failure behavior of textured or periodic heterogeneous materials is strongly influenced by their mesostructure. Their periodicity and the quasi-brittle nature of their constituents result in complex behaviors such as damage-induced anisotropy properties with localization of damage, which are difficult to model by means of macroscopic closed-form constitutive laws. A computational homogenization procedure is used for the in-plane and out-of-plane behavior of such planar shells, and is combined with an acoustic tensor-based failure detection adapted to shell kinematics to detect the structural-scale failure. Based on an assumption of single period failure, the localization of damage at the structural scale is represented by means of mesostructurally informed embedded strong discontinuities incorporated in the macroscopic shell description. A new enhanced scale transition is outlined for shell failure, based on an approximate energy consistency argument to objectively upscale the energy dissipation. The corresponding multi-scale framework results are compared with direct fine-scale modeling results used as a reference for the case of masonry, showing good agreement in terms of the load-bearing capacity, of failure mechanisms and of associated energy dissipation. © 2010 John Wiley & Sons, Ltd. [less ▲]

Detailed reference viewed: 10 (2 ULg)
See detailInventaire des archives de la Société anonyme métallurgique d'Espérance-Longdoz (1806-1971)
Delvaux, Anne-Catherine ULg

Book published by Archives générales du Royaume (2011)

Detailed reference viewed: 8 (0 ULg)
Full Text
Peer Reviewed
See detailFuran formation in baby food model system via lipid oxidation and sugar degradation
Owczarek-Fendor, Agnieszka; De Meulenaer, Bruno; Scholl, Georges ULg et al

in Communications in Agricultural and Applied Biological Sciences (2011), 76(1), 107-110

Detailed reference viewed: 30 (8 ULg)
Full Text
Peer Reviewed
See detailTelomere deregulations possess cytogenetic, phenotype, and prognostic specificities in acute leukemias.
CAPRARO, Valérie ULg; Zane, Linda; Poncet, Delphine et al

in Experimental Hematology (2011), 39(2), 195-2022

OBJECTIVE: Telomeres are protected by tightly regulated factors and elongated by telomerase. Short and/or deprotected chromosomes are recombinogenic and thereby cancer prone. MATERIALS AND METHODS ... [more ▼]

OBJECTIVE: Telomeres are protected by tightly regulated factors and elongated by telomerase. Short and/or deprotected chromosomes are recombinogenic and thereby cancer prone. MATERIALS AND METHODS: Together with the quantification of telomerase activity (TA), measuring telomere length (TL) and expression of the genes that govern telomere protection and elongation are useful for assessing telomere homeostasis. RESULTS: By these means we demonstrate that TL, hTERT, and TA are in the order acute myelogenous leukemia (AML) > T-cell acute lymphoblastic leukemia (T-ALL) > B-cell acute lymphoblastic leukemia (B-ALL) > T-ALL > AML, and B-ALL > AML > T-ALL. AML0 and AML3 display the lowest amounts of hTERT transcripts, and ALL and AML cells with cytogenetic abnormalities possess the shortest telomeres. hTERT expression includes phenotype-specific RNA maturation and correlates with TA but not with TL. A wide ratio of TA to hTERT expression between leukemia subtypes suggests phenotype-specific hTERT post-transcriptional deregulations. B- and T-ALL overexpress Ku70 and Pinx1, T-ALL PTOP and RAP1, and B-ALL TRF2, the expression of which is significantly higher in cases with abnormal karyotype. hTERT transcription and TL correlate with response to intensive chemotherapy, and hTERT and RAD50 are independent prognostic factors for survival. CONCLUSIONS: Each leukemia subtype possesses specific telomere dysregulations that rely on phenotype, karyotype, response to treatment, and survival. [less ▲]

Detailed reference viewed: 40 (9 ULg)
Full Text
Peer Reviewed
See detailPotential Therapeutic Target Discovery by 2D-DIGE Proteomic Analysis in Mouse Models of Asthma
QUESADA CALVO, Florence ULg; Fillet, Marianne ULg; Renaut, Jenny et al

in Journal of Proteome Research (2011), 10(9), 4291-4301

As asthma physiopathology is complex and not fully understood to date; it is expected that new key mediators are still to be unveiled in this disease. The main objective of this study was to discover ... [more ▼]

As asthma physiopathology is complex and not fully understood to date; it is expected that new key mediators are still to be unveiled in this disease. The main objective of this study was to discover potential new target proteins with a molecular weight >20 kDa by using two-dimensional differential in-gel electrophoresis (2D-DIGE) on lung parenchyma extracts from control or allergen-exposed mice (ovalbumin). Two different mouse models leading to the development of acute airway inflammation (5 days allergen exposure) and airway remodeling (10 weeks allergen exposure) were used. This experimental setting allowed the discrimination of 33 protein spots in the acute inflammation model and 31 spots in the remodeling model displaying a differential expression. Several proteins were then identified by MALDI-TOF/TOF MS. Among those differentially expressed proteins, PDIA6, GRP78, Annexin A6, hnRPA3, and Enolase display an increased expression in lung parenchyma from mice exposed to allergen for 5 days. Conversely, Apolipoprotein A1 was shown to be decreased after allergen exposure in the same model. Analysis on lung parenchyma of mice exposed to allergens for 10 weeks showed decreased calreticulin levels. Changes in the levels of those different mediators were confirmed by Western blot and immunohistochemical analysis. Interestingly, alveolar macrophages isolated from lungs in the acute inflammation model displayed enhanced levels of GRP78. Moreover, intratracheal instillation of anti-GRP78 siRNA in allergen-exposed animals led to a decrease in eosinophilic inflammation and bronchial hyperresponsiveness. This study unveils new mediators of potential importance that are up- and down-regulated in asthma. Among up-regulated mediators, GRP-78 appears as a potential new therapeutic target worthy of further investigations. [less ▲]

Detailed reference viewed: 58 (18 ULg)
Full Text
Peer Reviewed
See detailLong-term denosuamab treatment in postmenopausal women with osteoporosis : results from the first two years of the FREEDOM trial extension
Bone, H.; Chapurlat, R.; Brandi, M. et al

in Osteoporosis International (2011), 22(S4), 527-528

Detailed reference viewed: 16 (1 ULg)
Full Text
Peer Reviewed
See detailRole of the Focal Adhesion Protein Kindlin-1 in Breast Cancer Growth and Lung Metastasis.
Sin, S.; Bonin, F.; Petit, V. et al

in Journal of the National Cancer Institute (2011), 103

Background Fermitin family member 1 (FERMT1, Kindlin-1) is an epithelial-specific regulator of integrin functions and is associated with Kindler syndrome, a genetic disorder characterized by skin ... [more ▼]

Background Fermitin family member 1 (FERMT1, Kindlin-1) is an epithelial-specific regulator of integrin functions and is associated with Kindler syndrome, a genetic disorder characterized by skin blistering, atrophy, and photosensitivity. However, the possible role of kindlin-1 in cancer remains unknown. Methods Kindlin-1 expression was quantified in several human cancers using quantitative real-time polymerase chain reaction and published microarray datasets. The association between kindlin-1 expression and patient metastasis-free survival (N = 516) was assessed with Kaplan-Meier analyses. Effects of ectopic expression or silencing of kindlin-1 on cell signaling, migration, and invasion were assessed in human breast cancer cell lines using western blotting, immunofluorescence, wound healing assays, and invasion on Matrigel or type I collagen substrates. Breast tumor growth and lung metastasis were evaluated in 12-week-old female BALB/c mice (10 controls and six Kindlin-1-knockdown mice). All statistical tests were two-sided. Results Kindlin-1 expression was consistently higher in tumors than in normal tissues in various cancer types metastasizing to the lungs, including colon and bladder cancer. Kindlin-1 expression was associated with metastasis-free survival in both breast and lung adenocarcinoma (breast cancer: hazard ratio of lung metastasis = 2.55, 95% confidence intervals [CI] = 1.39 to 4.69, P = .001; lung cancer: hazard ratio of metastasis = 1.96, 95% CI = 1.25 to 3.07, P = .001). Overexpression of kindlin-1 induced changes indicating epithelial-mesenchymal transition and transforming growth factor beta (TGFbeta) signaling, constitutive activation of cell motility, and invasion (number of migrating cells, Kindlin-1 cells vs control, mean = 164.66 vs 19.00, difference = 145.6, 95% CI = 79.1 to 212.2, P = .004; invasion rate, Kindlin-1-cells vs control = 9.65% vs 1.92%, difference = 7.73%, 95% CI = 4.75 to 10.70, P < .001). Finally, Kindlin-1 depletion in an orthotopic mouse model statistically significantly inhibited breast tumor growth (P < .001) and lung metastasis (P = .003). Conclusion These results suggest a role for kindlin-1 in breast cancer lung metastasis and lung tumorigenesis and advance our understanding of kindlin-1 as a regulator of TGFbeta signaling, offering new avenues for therapeutic intervention against cancer progression. [less ▲]

Detailed reference viewed: 22 (8 ULg)
Full Text
Peer Reviewed
See detailAssessment of Crohn’s disease activity by FDG-PET/CT through a novel quantitative approach.
SABOURY, B.; HUSTINX, Roland ULg; BROTHERS, B. et al

in Journal of Nuclear Medicine (The) (2011), 52(SUPPL), 284

Detailed reference viewed: 3 (0 ULg)
Full Text
Peer Reviewed
See detailAn extended thermodynamic model of transient heat conduction at sub-continuum scales
Lebon, Georgy ULg; Machrafi, Hatim ULg; Grmela, M. et al

in Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences (2011), 467

A thermodynamic description of transient heat conduction at small length and timescales is proposed. It is based on extended irreversible thermodynamics and the main feature of this formalism is to ... [more ▼]

A thermodynamic description of transient heat conduction at small length and timescales is proposed. It is based on extended irreversible thermodynamics and the main feature of this formalism is to elevate the heat flux vector to the status of independent variable at the same level as the classical variable, the temperature. The present model assumes the coexistence of two kinds of heat carriers: diffusive and ballistic phonons. The behaviour of the diffusive phonons is governed by a Cattaneo-type equation to take into account the high-frequency phenomena generally present at nanoscales. To include non-local effects that are dominant in nanostructures, it is assumed that the ballistic carriers are obeying a Guyer–Krumhansl relation. The model is applied to the problem of transient heat conduction through a thin nanofilm. The numerical results are compared with those provided by Fourier, Cattaneo and other recent models. [less ▲]

Detailed reference viewed: 20 (5 ULg)
Full Text
Peer Reviewed
See detailDensity of states of chaotic Andreev billiards
Kuipers, Jack; Engl, Thomas; Berkolaiko, Gregory et al

in PHYSICAL REVIEW B (2011), 83(19), 195316-21

Quantum cavities or dots have markedly different properties depending on whether their classical counterparts are chaotic or not. Connecting a superconductor to such a cavity leads to notable proximity ... [more ▼]

Quantum cavities or dots have markedly different properties depending on whether their classical counterparts are chaotic or not. Connecting a superconductor to such a cavity leads to notable proximity effects, particularly the appearance, predicted by random matrix theory, of a hard gap in the excitation spectrum of quantum chaotic systems. Andreev billiards are interesting examples of such structures built with superconductors connected to a ballistic normal metal billiard since each time an electron hits the superconducting part it is retroreflected as a hole (and vice versa). Using a semiclassical framework for systems with chaotic dynamics, we show how this reflection, along with the interference due to subtle correlations between the classical paths of electrons and holes inside the system, is ultimately responsible for the gap formation. The treatment can be extended to include the effects of a symmetry-breaking magnetic field in the normal part of the billiard or an Andreev billiard connected to two phase-shifted superconductors. Therefore, we are able to see how these effects can remold and eventually suppress the gap. Furthermore, the semiclassical framework is able to cover the effect of a finite Ehrenfest time, which also causes the gap to shrink. However, for intermediate values this leads to the appearance of a second hard gap-a clear signature of the Ehrenfest time. [less ▲]

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailAnalyse des pigments des dessins pariétaux de la grotte Chauvet à Vallon-Pont-d'Arc
Laval, Eric; Salomon, Hélène ULg; Vignaud, Colette et al

Conference (2011)

Detailed reference viewed: 47 (3 ULg)
Full Text
See detailL’aide juridique de S. Boonen
Berthe, Aude ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2011)

Detailed reference viewed: 13 (1 ULg)
Full Text
Peer Reviewed
See detailRetrieving semantic information from persons’ names.
Barsics, Catherine ULg

Poster (2011)

Detailed reference viewed: 18 (6 ULg)
Full Text
Peer Reviewed
See detailAtomic oxygen distributions in the Venus thermosphere: Comparisons between Venus Express observations and global model simulations
Brecht, A.; Bougher, S. W.; Gérard, Jean-Claude ULg et al

in Icarus: International Journal of Solar System Studies (2011)

Detailed reference viewed: 12 (1 ULg)