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See detailLe Michelsberg de Pont-de-Bonne (province de Liège, Belgique)
Delye, Emmanuel ULg; Gilson, Simon-Pierre; Noiret, Pierre ULg

in Revue Archéologique de Picardie (2011)

Since the beginning of research on the éperon barré of Pont-de-Bonne (Modave, Belgium), we have recovered artefacts attributed to the Middle Neolithic. More recently, during excavation of the entrance ... [more ▼]

Since the beginning of research on the éperon barré of Pont-de-Bonne (Modave, Belgium), we have recovered artefacts attributed to the Middle Neolithic. More recently, during excavation of the entrance system of the fortification, a pot hole and a waste accumulation zone have been analysed. These structures contained abundant archaeological material (ceramic sherd, lithic and bone artefact and fauna). Three radiometric dates have been obtained. The ceramic assemblage is typical of the Belgian Michelsberg and a decorated vase shows Bischheim affinities. [less ▲]

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See detailUrinary NGAL measurement : Biological variation and ratio to creatinine
Delanaye, Pierre ULg; Rozet, Eric ULg; Krzesinski, Jean-Marie ULg et al

in Clinica Chimica Acta (2011), 412(3-4), 390

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See detailEthologie et psychiatrie : hommage au travail du Docteur Albert Demaret
Englebert, Jérôme ULg; Gauthier, Jean-Marie ULg

in Acta Psychiatrica Belgica (2011), 111(4), 8-12

Albert Demaret (1933-2011) is one of the pioneers of evolutionary psychiatry and of an ethological conception of psychopathology. In this paper, the authors propose a summary of the epistemological ... [more ▼]

Albert Demaret (1933-2011) is one of the pioneers of evolutionary psychiatry and of an ethological conception of psychopathology. In this paper, the authors propose a summary of the epistemological context of his work and detail its approach to anorexia nervosa and bipolar disorder. [less ▲]

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See detailIs there really an Azores diversity enigma? Insights from the phylogeography of the heather Erica scoparia s.l.
Desamore, Aurélie ULg

Poster (2011)

The Azorean flora, in contrast to that of other archipelagos, is characterized by a paucity of evolutionary radiations and the widespread distribution of most endemics. Several hypotheses, including ... [more ▼]

The Azorean flora, in contrast to that of other archipelagos, is characterized by a paucity of evolutionary radiations and the widespread distribution of most endemics. Several hypotheses, including isolation from the continent, recent age, ecological homogeneity, and limited paleoclimatic variations, have been proposed to account for this pattern. These hypotheses are tested here within the context of the molecular phylogeography of the heather Erica scoparia s.l., a Mediterraneo-Atlantic species complex distributed across Macaronesia, North Africa and southwestern Europe. The marked molecular radiation of this species in the Azores, including an array of single-island endemics, suggests that the apparent homogeneity of the Azorean flora might, in fact, conceal undetected patterns of endemism that are similar to those observed in the Canarian flora for morphological data. Haplotype richness was higher in the Azores than in the Canaries and extensive dispersal mediated allopatry is apparent at the molecular level. The Azores were colonized at least twice independently by E. scoparia, whereas the Canarian haplotypes are monophyletic, suggesting that the greater distance between the Azores and the continent does not necessarily hamper the chances of successful colonization. [less ▲]

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See detailThe Herschel view of nebulae around evolved massive stars
Vamvatira-Nakou, Chloi ULg; Royer, P.; Hutsemekers, Damien ULg et al

Conference (2011)

The detailed study of the nebulae ejected from Luminous Blue Variables and the circumstellar bubbles around Wolf-Rayet stars, which radiate strongly in the IR due to the heating of dust, is crucial for ... [more ▼]

The detailed study of the nebulae ejected from Luminous Blue Variables and the circumstellar bubbles around Wolf-Rayet stars, which radiate strongly in the IR due to the heating of dust, is crucial for understanding the massive stars evolution. With Herschel, the largest telescope ever flown in space, we are able to study the gas and the dust in these circumstellar environments in the full far-infrared waveband. In the context of 'Mass-loss of Evolved StarS' Herschel guaranteed time key programme, we have obtained imaging and spectroscopic observations of nebulae associated with Luminous Blue Variable and Wolf-Rayet stars using PACS, one of the three instruments onboard Herschel. A description of these observations and first results of the data analysis are presented. [less ▲]

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See detailBrain functional integration decreases during propofol-induced loss of consciousness.
Schrouff, Jessica ULg; Perlbarg, Vincent; Boly, Mélanie ULg et al

in NeuroImage (2011), 57(1), 198-205

Consciousness has been related to the amount of integrated information that the brain is able to generate. In this paper, we tested the hypothesis that the loss of consciousness caused by propofol ... [more ▼]

Consciousness has been related to the amount of integrated information that the brain is able to generate. In this paper, we tested the hypothesis that the loss of consciousness caused by propofol anesthesia is associated with a significant reduction in the capacity of the brain to integrate information. To assess the functional structure of the whole brain, functional integration and partial correlations were computed from fMRI data acquired from 18 healthy volunteers during resting wakefulness and propofol-induced deep sedation. Total integration was significantly reduced from wakefulness to deep sedation in the whole brain as well as within and between its constituent networks (or systems). Integration was systematically reduced within each system (i.e., brain or networks), as well as between networks. However, the ventral attentional network maintained interactions with most other networks during deep sedation. Partial correlations further suggested that functional connectivity was particularly affected between parietal areas and frontal or temporal regions during deep sedation. Our findings suggest that the breakdown in brain integration is the neural correlate of the loss of consciousness induced by propofol. They stress the important role played by parietal and frontal areas in the generation of consciousness. [less ▲]

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See detailCharacterization of the response of GFP microbial biosensors sensitive to substrate limitation in scale-down bioreactors
Delvigne, Frank ULg; Brognaux, Alison ULg; Gorret, Nathalie et al

in Biochemical Engineering Journal (2011), 55(2), 131-139

The dynamics of microbial stress response in intensive cultivation conditions remains not completely understood. In this work, two green fluorescent protein (GFP) transcriptional reporters have been used ... [more ▼]

The dynamics of microbial stress response in intensive cultivation conditions remains not completely understood. In this work, two green fluorescent protein (GFP) transcriptional reporters have been used as biosensors of the heterogeneities generated in a two-compartment scale-down reactor. The stress promoters have been chosen for their responsiveness to carbon limitation corresponding to the global substrate profiles encountered in intensive fed-batch cultures. From our results, it can be concluded that the exposure of microbial cells to substrates heterogeneities tends to decrease the GFP expression level in fed-batch mode. Fluorescence intensities have been monitored at the single cell level by using flow cytometry. During the course of the fed-batch culture, a drop at the level of the intracellular GFP content has been observed for the two scale-down operating conditions and for the two promoters sensitive to substrate limitation (rpoS and csiE). The fluorescence drop can be attributed to the repression of these promoters but also to the release of GFP to the extracellular medium according to the increase of the fluorescence level of the supernatant. This leakage has been observed for all the operating conditions, i.e. the scale-down reactors and the culture operating in the normal mode, i.e. in a well-mixed bioreactor. Interestingly, GFP leakage is more pronounced in the case of the cultures operated in the normal mode. Indeed, staining by propidium iodide tends to be more elevated for the microbial cells cultured under the normal mode by comparison with those cultured in scale-down conditions, indicating a higher permeability of the membrane. These results suggest that GFP microbial biosensors could be used to detect simultaneously mixing imperfections and their impact on the viability of microorganisms. [less ▲]

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See detailSource parameters of the 2008 Bukavu-Cyangugu earthquake estimated from InSAR and teleseismic data
d'Oreye, Nicolas; Gonzalez, P.; Shuler, A. et al

in Geophysical Journal International (2011)

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See detailBoolean Functions: Theory, Algorithms, and Applications
Crama, Yves ULg; Hammer, Peter L.

Book published by Cambridge University Press (2011)

This monograph provides the first comprehensive presentation of the theoretical, algorithmic and applied aspects of Boolean functions, i.e., {0,1}-valued functions of a finite number of {0,1}-valued ... [more ▼]

This monograph provides the first comprehensive presentation of the theoretical, algorithmic and applied aspects of Boolean functions, i.e., {0,1}-valued functions of a finite number of {0,1}-valued variables. The book focuses on algebraic representations of Boolean functions, especially normal form representations. It presents the fundamental elements of the theory (Boolean equations and satisfiability problems, prime implicants and associated representations, dualization, etc.), an in-depth study of special classes of Boolean functions (quadratic, Horn, shellable, regular, threshold, read-once, etc.), and two fruitful generalizations of the concept of Boolean functions (partially defined and pseudo-Boolean functions). It features a rich bibliography of about one thousand items. Prominent among the disciplines in which Boolean methods play a significant role are propositional logic, combinatorics, graph and hypergraph theory, complexity theory, integer programming, combinatorial optimization, game theory, reliability theory, electrical and computer engineering, artificial intelligence, etc. The book contains applications of Boolean functions in all these areas. [less ▲]

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See detailLe mécénat féminin en France et en Bourgogne (XVe-XVIe siècles). Nouvelles perspectives. Actes de la journée d'études internationale tenue à l'Université de Liège, le 10 mai 2010
Fagnart, Laure ULg; L'Estrange, Elizabeth

Book published by De Boeck (2011)

Le rôle joué par les femmes de pouvoir au Moyen Âge et au tout début de la Renaissance dans la commande d’œuvres artistiques et culturelles constitue un champ de recherche de plus en plus prolifique. La ... [more ▼]

Le rôle joué par les femmes de pouvoir au Moyen Âge et au tout début de la Renaissance dans la commande d’œuvres artistiques et culturelles constitue un champ de recherche de plus en plus prolifique. La présente collection d’articles, suscitée par une journée d’études intitulée "Le mécénat féminin en France et en Bourgogne (XVe-XVIe siècles). Nouvelles perspectives", qui a eu lieu à l’Université de Liège en 2010, illustre l’importance des femmes mécènes, en France et en Bourgogne, dans les domaines de l’architecture, de l’orfèvrerie, des manuscrits enluminés, de la peinture et de la sculpture, ainsi que dans la traduction et dans l’organisation des cérémonials. Dans leurs fonctions respectives, celles de reine, reine mère, duchesse, régente, dame d’honneur, les femmes font usage des œuvres d’art et des rites pour promouvoir leurs intérêts personnels et dynastiques, confrontées qu’elles sont aux difficultés liées à leur sexe et à leur statut de femme de pouvoir, ou à des difficultés telles que les rivalités, la guerre, ou la folie. Même s’il est clair que les cours française et bourguignonne constituent l’espace le plus favorable à l’efflorescence du mécénat féminin, cette collection démontre toutefois l’existence d’un même phénomène, important, en dehors des sphères royales. [less ▲]

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See detailSynchronization on the circle
Sarlette, Alain ULg; Sepulchre, Rodolphe ULg

in Dubbeldam; Green; Lenstra (Eds.) "The complexity of dynamical systems: a multi-disciplinary perspective" (2011)

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See detailOptimization of multibody systems and their structural components
Bruls, Olivier ULg; Lemaire, Etienne ULg; Duysinx, Pierre ULg et al

in Blajer, W.; Arczewski, K.; Fraczek, J. (Eds.) et al Multibody Dynamics: Computational Methods and Applications (2011)

This work addresses the optimization of flexible multibody systems based on the dynamic response of the full system with large amplitude motions and elastic deflections. The simulation model involves a ... [more ▼]

This work addresses the optimization of flexible multibody systems based on the dynamic response of the full system with large amplitude motions and elastic deflections. The simulation model involves a nonlinear finite element formulation, a time integration scheme and a sensitivity analysis and it can be efficiently exploited in an optimization loop. In particular, the paper focuses on the topology optimization of structural components embedded in multibody systems. Generally, topology optimization techniques consider that the structural component is isolated from the rest of the mechanism and use simplified quasi-static load cases to mimic the complex loadings in service. In contrast, we show that an optimization directly based on the dynamic response of the flexible multibody system leads to a more integrated approach. The method is applied to truss structural components. Each truss is represented by a separate structural universe of beams with a topology design variable attached to each one. A SIMP model (or a variant of the power law) is used to penalize intermediate densities. The optimization formulation is stated as the minimization of the mean compliance over a time period or as the minimization of the mean tip deflection during a given trajectory, subject to a volume constraint. In order to illustrate the benefits of the integrated design approach, the case of a two degrees-of-freedom robot arm is developed. [less ▲]

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See detailImpact of chronic graft-versus-host disease (GVHD) after reduced intensity conditioning (RIC) allogeneic stem cell transplantation (allo-SCT) as treatment for acute myeloid leukemia (AML) : a survey from the Acute Leukemia Working Party of the EBMT
Baron, Frédéric ULg; Labopin, Myriam; Niederwieser, Dietger et al

in Blood (2011), 118

The goal of RIC allo-SCT is to harness the graft-versus-leukemia (GVL) effect, while minimizing toxicities and the risk of GVHD. However, prior studies have shown a lower risk of relapse in AML patients ... [more ▼]

The goal of RIC allo-SCT is to harness the graft-versus-leukemia (GVL) effect, while minimizing toxicities and the risk of GVHD. However, prior studies have shown a lower risk of relapse in AML patients (pts) who experienced chronic GVHD after RIC allo-SCT versus in those who did not. Here, we investigated the impact of occurrence of GVHD on transplantation outcomes in a large cohort of AML pts given allogeneic PBSC after RIC conditioning. Data from 1859 AML pts in first (n=1439) or second (n=420) CR transplanted between 2000 and 2009 following a RIC regimen at EBMT affiliated centres were analyzed. Pts were given PBSC from HLA-identical sibling (MRD, n=1208), or from HLA-matched unrelated donors (MUD, n=651). Median pt age at transplantation was 56 y (range, 18–77). 338 male pts were given grafts from female donors. RIC was based on low-dose TBI in 520 (28%) pts, while the remaining pts received chemotherapy-based RIC. ATG was given in 269 (22%) MRD and in 267 (41%) MUD recipients, respectively, while 151 (13%) MRD and 165 (25%) MUD recipients received in-vivo T cell depletion with alemtuzumab. The impact of chronic GVHD on relapse risk, non-relapse mortality (NRM), leukemia-free survival (LFS), and overall survival (OS) was assessed using time-dependent multivariate Cox models and in a landmark analysis at 18 months after transplant. Three-year incidences of relapse, NRM, LFS and OS were 34±1%, 15±1%, 51±2% and 60±2% in MRD recipients, respectively, and 34±2% (p=NS), 24±2% (P<0.001), 42±2% (P=0.001) and 47±2% (P=0.001) in MUD recipients, respectively. Grade II, III and IV acute GVHD were observed in 133 (11%), 61 (5%) and 30 (2%) MRD recipients and in 119 (18%), 41 (6%) and 24 (4%) MUD recipients, respectively. The 3-y cumulative incidence of chronic GVHD was 47%. Fifty-three percent of patients with chronic GVHD had extensive chronic GVHD, while the remaining 47% had limited chronic GVHD. In multivariate analyses, occurrence of grade II-IV acute GVHD was associated with a lower risk of relapse (HR=0.8; P=0.04), a higher risk of chronic (HR=2.2; P<0.001) and extensive chronic GVHD (HR=2.8; P<0.001), a higher risk of NRM (HR=2.4 P<0.001), a worsened LFS (HR=1.3; P=0.01), and a worsened OS (HR=1.5; P<0.001). In multivariate time-dependent analyses, occurrence of limited chronic GVHD was associated with a lower risk of relapse (HR=0.7; P=0.05), comparable NRM (HR=1.4; P=0.16), comparable LFS (HR=0.9; P=0.29) and better OS (HR=0.5; P<0.001), while occurrence of extensive chronic GVHD was associated with a lower risk of relapse (HR=0.6; P=0.01), higher NRM (HR=3.2; P<0.001), a trend for worsened LFS (HR=1.3; P=0.06) and comparable OS (HR=0.9; P=0.34). The median interval from transplantation to occurrence of chronic GVHD was 163 (range, 100–1545) days. To further assess the graft-versus-leukemia effect of chronic GVHD, we performed a landmark analysis in patients who were leukemia-free at 18 months after transplantation (n=776). Median follow-up from this landmark time-point was 24 (range, 0.1–112) months. Two-year relapse, NRM, LFS and OS were 16±2%, 2.5±1%, 82±2%, and 89±2%, respectively, in patients without chronic GVHD before the landmark time-point, versus 9±1% (P=0.001), 8±1% (P<0.001), 83±2% (P=0.65), and 86±2% (P=0.38), respectively, in patients with chronic GVHD before the landmark time-point.In conclusion, in this cohort of AML patients transplanted in remission, occurrence of chronic GVHD was associated with a lower risk of relapse that translated to better OS in patients with limited chronic GVHD but not in those with extensive chronic GVHD who experienced higher long term NRM, highlighting the need for long term prospective assessment of long term effects and quality of life in patients receiving RIC allo-SCT. [less ▲]

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See detailTax Evasion, Welfare Fraud, and "The Broken Windows" Effect: An Experiment in Belgium, France and the Netherlands
Lefebvre, Mathieu ULg; Pestieau, Pierre ULg; Riedl, Arno et al

E-print/Working paper (2011)

In a series of experiments conducted in Belgium (Wallonia and Flanders), France and the Netherlands, we compare behavior regarding tax evasion and welfare dodging, with and without information about ... [more ▼]

In a series of experiments conducted in Belgium (Wallonia and Flanders), France and the Netherlands, we compare behavior regarding tax evasion and welfare dodging, with and without information about others’ behavior. Subjects have to decide between a ‘registered’ income, the realization of which will be known to the tax authority for sure, and an ‘unregistered’ income that will only be known with some probability. This unregistered income comes from self-employment in the Tax treatment and from black labor supplementing some unemployment compensation in the Welfare treatment. Subjects have then to decide on whether reporting their income or not, knowing the risk of detection. The results show that (i) individuals evade more in the Welfare treatment than in the Tax treatment; (ii) many subjects choose an option that allows for tax evasion or welfare fraud but report their income honestly anyway; (iii) examples of low compliance tend to increase tax evasion while examples of high compliance exert no influence; (iv) tax evasion is more frequent in France and the Netherlands; Walloons evade taxes less than the Flemish. There is no cross-country difference in welfare dodging. [less ▲]

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See detailEtude de l'activité antifongique des bactéries lactiques isolées de produits alimentaires fermentés et caractérisation de leurs métabolites inhibiteurs
Ndagano, Dora ULg

Doctoral thesis (2011)

Summary: The aim of this present research was to study the antifungal properties of lactic acid bacteria (LAB) isolated from fermented Mill flour and fermented cassava in order to use them for ... [more ▼]

Summary: The aim of this present research was to study the antifungal properties of lactic acid bacteria (LAB) isolated from fermented Mill flour and fermented cassava in order to use them for biopreservation. Antifungal activity of these LAB were assessed in MRS solid medium against food spoilage moulds as Aspergillus niger MUCL 28699, Aspergillus niger CWBIF194, Aspergillus tubingensis MP1 and Penicillium crustosum MY1. Three strains, Lactobacillus plantarum VE56, Weissella cibaria FMF4B16 and Weissella paramesenteroides LC11 were selected among 116 for their strongest inhibitory activity and their broad inhibitory spectrum against food moulds. The 4-fold concentrated supernatant of L. plantarum VE56 and W. paramesenteroides LC11 had the strongest inhibitory activity to compare to W. cibaria FMF4B16. The antifungal activity of the cell-free supernatant was pH dependent and insensitive to proteolytic enzymes action suggesting that the inhibitory activity was due to other compounds than proteins. The identification of antifungal compounds by chromatographic studies highlighted the production of phenyllactic acid by the three strains. In addition, 2-hydroxy-3-methylpentanoic acid and 2-hydroxy-4-methylpentanoic acid were produced by L. plantarum VE56 and W. paramesenteroides LC11. However, the concentration assessed in the supernatant was lower than the minimal inhibitory concentration showing a synergic action of all these produced compounds. The effect of the antifungal supernatant of L. plantarum VE56 and W. paramesenteroides LC11 on Aspergillus flavus NRRL 3357 resulted to an inhibition of conidial development and aflatoxin B1 production which was reflected in decreased gene expression of brlA (conidiophore specific transcription factor) and laeA (global regulator of secondary metabolism). These two bacteria also delayed Penicillium expansum MUCL 14498 conidial development in bread. [less ▲]

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