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See detailDiallyl disulfides: comparison between classical and microwave-assisted synthesis
DETHIER, Bérénice ULg; Richel, Aurore ULg; Laurent, Pascal ULg et al

in Ioannou, Efstathia; Roussis, Vassilios (Eds.) Trends in Natural Products Research: Abstracts of the Phytochemical Society of Europe (2011)

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See detailQuelques adverbes négatifs en grec ancien sous l'angle du cycle de Jespersen
Denizot, Camille ULg

in Lalies (2011), 31

This article deals with the negative adverbs in Ancient Greek which can take two forms (οὔποτε / οὐδέποτε, οὔπω / οὐδέπω, οὐπώποτε / οὐδεπώποτε). For this purpose, it adopts a diachronic point of view ... [more ▼]

This article deals with the negative adverbs in Ancient Greek which can take two forms (οὔποτε / οὐδέποτε, οὔπω / οὐδέπω, οὐπώποτε / οὐδεπώποτε). For this purpose, it adopts a diachronic point of view (from Homeric poems to IInd A.D.). The adverbs with –δε‐ first appeared as coordinators, and were then employed as reinforced and emphatic forms, and hardly ever as focal forms. These emphatic adverbs finally overtook the corresponding forms without –δε‐, and lost their emphatic characteristics, according to the evolution put forward by Jespersen. When authors from the IInd century A.D. follow the classical pattern, their imitation is shaped by this evolution. [less ▲]

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See detailHPV triggers NK cell cytotoxic activity and cytokine secretion
Jacobs, Nathalie ULg; Renoux, Virginie ULg; Bisig, Bettina ULg et al

Conference (2011)

Background The immune system controls, at least partially, human papillomavirus (HPV) infection and subsequent tumor development as demonstrated by a higher tumor prevalence in immunodeficient patients ... [more ▼]

Background The immune system controls, at least partially, human papillomavirus (HPV) infection and subsequent tumor development as demonstrated by a higher tumor prevalence in immunodeficient patients. Around 90% of HPV-infected women will clear the virus within two years. However, it remains unclear which immune cells are implicated in this process and no study has been performed evaluating the direct interaction between HPV and Natural Killer (NK) cells although these cells play a key role in host resistance to virus and tumor. Methods/Results By immunochemistry, we demonstrated an NK cell infiltration in HPV+ squamous pre-neoplasic lesions. Since HPV cannot grow in vitro, virus-like particles (VLP) were used as a model for studying the NK cell response against the virus. Interestingly, NK cells displayed a higher cytotoxic activity (CD107 and chromium release assays) and cytokine production (TNF-α and IFN-γ) in the presence of HPV-VLP. Uptake of HPV-VLP by dendritic cells (DC) has been shown to induce their activation, therefore, we investigated by flow cytometry and microscopy whether the stimulation of NK cell activity is linked to VLP internalization. We observed a faster entry into these cells compared to DC. Furthermore, virus uptake by NK cells is mediated by macropinocytosis, whereas this entry is dependent on clathrin or caveolin endocytosis pathways in DC. Using NK cell lines expressing or not CD16 and blocking antibody, we demonstrated that CD16 is necessary for HPV-VLP internalization, but also for degranulation and cytokine production. Conclusion Thus, we show for the first time that NK cells interact with HPV and could participate in the immune response against HPV-induced tumors. [less ▲]

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See detailThe Mons campaign on OB stars
Morel, Thierry ULg; Rauw, Grégor ULg; Eversberg, T. et al

in Bulletin de la Société Royale des Sciences de Liège (2011), 80

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See detailThe ratio bias phenomenon: fact or artifact?
Lefebvre, Mathieu ULg; Vieder, Ferdinand; Villeval, MArie-Claire

in Theory and Decision (2011), 71(4), 615-641

The ratio bias—according to which individuals prefer to bet on probabilities expressed as a ratio of large numbers to normatively equivalent or superior probabilities expressed as a ratio of small ... [more ▼]

The ratio bias—according to which individuals prefer to bet on probabilities expressed as a ratio of large numbers to normatively equivalent or superior probabilities expressed as a ratio of small numbers—has recently gained momentum, with researchers especially in health economics emphasizing the policy importance of the phenomenon. Although the bias has been replicated several times, some doubts remain about its economic significance. Our two experiments show that the bias disappears once order effects are excluded, and once salient and dominant incentives are provided. This holds true for both choice and valuation tasks. Also, adding context to the decision problem does not alter this finding. No ratio bias could be found in between-subject tests either, which leads us to the conclusion that the policy relevance of the phenomenon is doubtful at best. [less ▲]

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See detailLinearly polarized second harmonic generation microscopy reveals chirality (vol 18, pg 8286, 2010)
Valev, V. K.; Silhanek, Alejandro ULg; Smisdom, N. et al

in Optics Express (2011), 19(10), 9242-9244

An erratum is presented to clarify both the direction of light polarization in our experiments and the unit cell geometry of the samples. Additionally, the spectral dependence of the second harmonic ... [more ▼]

An erratum is presented to clarify both the direction of light polarization in our experiments and the unit cell geometry of the samples. Additionally, the spectral dependence of the second harmonic generation response in the G-shaped nanostructures made of gold is corrected. These changes do not affect our previous conclusions. (C) 2011 Optical Society of America [less ▲]

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See detailEvaluating the reliability of analytical results using a probability criterion: a Bayesian perspective
Rozet, Eric ULg; Govaerts, B.; Lebrun, Pierre ULg et al

in Analytica Chimica Acta (2011), 705

Methods validation is mandatory in order to assess the fitness of purpose of the developed analytical method. Of core importance at the end of the validation is the evaluation of the reliability of the ... [more ▼]

Methods validation is mandatory in order to assess the fitness of purpose of the developed analytical method. Of core importance at the end of the validation is the evaluation of the reliability of the individual results that will be generated during the routine application of the method. Regulatory guidelines provide a general framework to assess the validity of a method, but none address the issue of results reliability. In this study, a Bayesian approach is proposed to address this concern. Results reliability is defined here as “the probability of an analytical method to provide analytical results within predefined acceptance limits around their reference or conventional true concentration values over a defined concentration range and under given environmental and operating conditions.” By providing the minimum reliability probability needed for the subsequent routine application of the method, as well as specifications or acceptance limits , the proposed Bayesian approach provides the effective probability of obtaining reliable future analytical results over the whole concentration range investigated. This is summarized in a single graph: the reliability profile. This Bayesian reliability profile is also compared to two frequentist approaches, the first one derived from the work of Dewé et al. [Dewé W., Govaerts B., Boulanger B., Rozet E., Chiap P., Hubert Ph., Chemometr. Intell. Lab. Syst. 85 (2007) 262-268] and the second proposed by Govaerts et al. [B. Govaerts, W. Dewé, M. Maumy, B. Boulanger, Qual. Reliab. Engng. Int. 24 (2008) 667-680]. Furthermore, to illustrate the applicability of the Bayesian reliability profile, this approach is also applied here to a bioanalytical method dedicated to the determination of ketoglutaric acid (KG) and hydroxymethylfurfural (HMF) in human plasma by SPE-HPLC-UV. [less ▲]

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See detailInfluence of response prepotency strength, general working memory resources, and specific working memory load on the ability to inhibit predominant responses: A comparison of young and elderly participants
Grandjean, Julien ULg; Collette, Fabienne ULg

in Brain & Cognition (2011), 77

One conception of inhibitory functioning suggests that the ability to successfully inhibit a predominant response depends mainly on the strength of that response, the general functioning of working memory ... [more ▼]

One conception of inhibitory functioning suggests that the ability to successfully inhibit a predominant response depends mainly on the strength of that response, the general functioning of working memory processes, and the working memory demand of the task (Roberts, Hager, and Heron, 1994). The proposal that inhibition and functional working memory capacity interact was assessed in the present study using two motor inhibition tasks (Go/No-Go and response incompatibility) in young and older participants. The strength of prepotency was assessed with a short or long training phase for the response to be inhibited. The influence of working memory resources was evaluated by administering the tasks in full versus divided attention conditions. The effect of working memory load was manipulated by increasing the number of target and distracter items in each task. Results showed no effect of prepotency strength, whereas dividing attentional resources and increasing working memory load were associated with greater inhibitory effects in both groups and for both tasks. This deleterious effect was higher for older participants, except in the working memory load condition of the Go/No-Go task. These results suggest an interactive link between working memory and response inhibition by showing that taxing working memory resources increases the difficulty of inhibiting prepotent responses in younger and older subjects. The additional detrimental effect of these factors on healthy elderly subjects was related to their decreased cognitive resources and to their shorter span size. [less ▲]

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See detailMicrostructure, crystalline phases and pore morphology of Onggi
Pontikes, Yiannis; Kerckhofs, Greet ULg; Kim, Ungsoo et al

in Proceedings ECerS XII (2011)

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See detailExperience-dependent induction of hypnagogic images during daytime naps: a combined behavioural and EEG study.
Kussé, Caroline ULg; Shaffii, Anahita ULg; Schrouff, Jessica ULg et al

in Journal of Sleep Research (2011)

This study characterizes hypnagogic hallucinations reported during a polygraphically recorded 90-min daytime nap following or preceding practice of the computer game Tetris. In the experimental group (N ... [more ▼]

This study characterizes hypnagogic hallucinations reported during a polygraphically recorded 90-min daytime nap following or preceding practice of the computer game Tetris. In the experimental group (N = 16), participants played Tetris in the morning for 2 h during three consecutive days, while in a first control group (N = 13, controlling the effect of experience) participants did not play any game, and in a second control group (N = 14, controlling the effect of anticipation) participants played Tetris after the nap. During afternoon naps, participants were repetitively awakened 15, 45, 75, 120 or 180 s after the onset of S1, and were asked to report their mental content. Reports content was scored by three judges (inter-rater reliability 85%). In the experimental group, 48 out of 485 (10%) sleep-onset reports were Tetris-related. They mostly consisted of images and sounds with very little emotional content. They exactly reproduced Tetris elements or mixed them with other mnemonic components. By contrast, in the first control group, only one report out of 107 was scored as Tetris-related (1%), and in the second control group only three reports out of 112 were scored as Tetris-related (3%; between-groups comparison; P = 0.006). Hypnagogic hallucinations were more consistently induced by experience than by anticipation (P = 0.039), and they were predominantly observed during the transition of wakefulness to sleep. The observed attributes of experience-related hypnagogic hallucinations are consistent with the particular organization of regional brain activity at sleep onset, characterized by high activity in sensory cortices and in the default-mode network. [less ▲]

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See detailMyopia, redistribution and pensions
Pestieau, Pierre ULg; Cremer, H.

in European Economic Review (2011), 55

This paper reviews a number of recent contributions that study pension design with myopic individuals. Its objective is to explore how the presence of more or less myopic individuals affects pension ... [more ▼]

This paper reviews a number of recent contributions that study pension design with myopic individuals. Its objective is to explore how the presence of more or less myopic individuals affects pension design when individuals differ also in productivity. This double heterogeneity gives rise to an interesting interplay between paternalistic and redistributive considerations, which is at the heart of most of the results that are presented. The main part of the paper is devoted to the issue of pension design when myopic individual do not save ‘‘enough’’ for their retirement because their ‘‘myopicself’’ (with a high discount rate) emerges when labor supply and savings decisions are made. Some extensions and variations are considered in the second part. In particular we deal with situations where labor disutility or preferences for consumption are subject to ‘‘habit formation’’and where sin goods have a detrimental effect on second period health. Myopic individuals tend to underestimate the effects of both habit formation and sinful consumption, which complicates public policy. [less ▲]

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See detailorigines de la vie: où, quand, comment?
Javaux, Emmanuelle ULg

Speech (2011)

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See detailEvaluation of saliva as an alternative matrix for monitoring plasma Zidovudine, Lamivudine and nevirapine concentrations in Rwanda
Gras, A; Schneider, S; Karasi, Jean Claude ULg et al

in Current HIV Research (2011), 9(4), 223-8

Saliva may provide interesting advantages as matrix for compliance measurements, pharmacokinetic studies and therapeutic drug monitoring in resource limited countries. We investigated the feasibility of ... [more ▼]

Saliva may provide interesting advantages as matrix for compliance measurements, pharmacokinetic studies and therapeutic drug monitoring in resource limited countries. We investigated the feasibility of using saliva for compliance monitoring of zidovudine (ZDV), lamivudine (3TC) and nevirapine (NVP) in 29 HIV-1 infected patients from Rwanda. ZDV, 3TC and NVP drug levels were quantified by an LC/MS-MS method in plasma and stimulated saliva samples and compared using Bland-Altman analysis. Seven patients demonstrated undetectable saliva ZDV levels while five out of these seven also showed no 3TC salivary concentrations. For the other samples, we observed a good agreement between salivary and plasma concentrations of each antiretroviral drug. A significant relation between the difference in saliva and plasma ZDV concentrations and the average ZDV concentration in the two matrices was deduced as follow: y = -380.15 + 1.79 x. The log saliva and plasma concentration difference of both 3TC and NVP was consistent across the range of average log concentration. Overall, we showed large agreement limits suggesting a wide inter patient variability that may result to non-reliable plasma level predictions from saliva drug measurements. Therefore, our results indicate that saliva may serve as a valuable tool only for NVP compliance testing because of its high salivary concentration. [less ▲]

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See detailEffects of light on cognitive brain responses depend on circadian phase and sleep homeostasis.
Vandewalle, Gilles ULg; Archer, Simon N; Wuillaume, Catherine et al

in Journal of biological rhythms (2011), 26(3), 249-59

Light is a powerful modulator of cognition through its long-term effects on circadian rhythmicity and direct effects on brain function as identified by neuroimaging. How the direct impact of light on ... [more ▼]

Light is a powerful modulator of cognition through its long-term effects on circadian rhythmicity and direct effects on brain function as identified by neuroimaging. How the direct impact of light on brain function varies with wavelength of light, circadian phase, and sleep homeostasis, and how this differs between individuals, is a largely unexplored area. Using functional MRI, we compared the effects of 1 minute of low-intensity blue (473 nm) and green light (527 nm) exposures on brain responses to an auditory working memory task while varying circadian phase and status of the sleep homeostat. Data were collected in 27 subjects genotyped for the PER3 VNTR (12 PER3(5/5) and 15 PER3(4/4) ) in whom it was previously shown that the brain responses to this task, when conducted in darkness, depend on circadian phase, sleep homeostasis, and genotype. In the morning after sleep, blue light, relative to green light, increased brain responses primarily in the ventrolateral and dorsolateral prefrontal cortex and in the intraparietal sulcus, but only in PER3(4/4) individuals. By contrast, in the morning after sleep loss, blue light increased brain responses in a left thalamofrontoparietal circuit to a larger extent than green light, and only so in PER3(5/5) individuals. In the evening wake maintenance zone following a normal waking day, no differential effect of 1 minute of blue versus green light was observed in either genotype. Comparison of the current results with the findings observed in darkness indicates that light acts as an activating agent particularly under those circumstances in which and in those individuals in whom brain function is jeopardized by an adverse circadian phase and high homeostatic sleep pressure. [less ▲]

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See detailESSENTIAL OIL COMPOSITION AND ANTIMICROBIAL ACTIVITY OF ARTEMISIA HERBA-ALBA ASSO GROWN IN MOROCCO
Imelouane, B.; El Bachiri, A.; Ankit, M. et al

in Banat's Journal of Biotechnology (2011), I(2),

Volatile components of Artemisia herba-alba Asso essential oil obtained by hydrodistillation growing in eastern Morocco (Taforalt) were investigated by GC/FID and GC-MS. The major components were found to ... [more ▼]

Volatile components of Artemisia herba-alba Asso essential oil obtained by hydrodistillation growing in eastern Morocco (Taforalt) were investigated by GC/FID and GC-MS. The major components were found to be camphor (43.07%), camphene (7.2%), 1,8-cineole (7.08%), filifolone (7.04%), borneol (4.88%), and bornyl acetate (3,79%).The essential oil has been tested for antimicrobial activity against Gram-negative and Gram-positive bacteria. Inhibition of growth was tested by the agar diffusion method. The minimal Inhibitory Concentration (MIC) was determined by the method of microtitration assay. [less ▲]

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See detailDe la nature et des mains jaillit l'étonnement...
Eloy, Céline ULg

in Flux News (2011), 54

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See detailCompte rendu de Nestor Chr. KAVVADAS, "Die Natur des Schlechten bei Proklos. Eine Platoninterpretation und ihre Rezeption durch Dionysios Areopagites"
Gavray, Marc-Antoine ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (2011), 80

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