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See detailEnhanced Activity of Meprin-a, a Pro-Migratory and Pro-Angiogenic Protease, in Colorectal Cancer
Lottaz, Daniel; Maurer, Christoph A; Noël, Agnès ULg et al

in PLoS ONE (2011), 6(11), 26450

Meprin-α is a metalloprotease overexpressed in cancer cells, leading to the accumulation of this protease in a subset of colorectal tumors. The impact of increased meprin-α levels on tumor progression is ... [more ▼]

Meprin-α is a metalloprotease overexpressed in cancer cells, leading to the accumulation of this protease in a subset of colorectal tumors. The impact of increased meprin-α levels on tumor progression is not known. We investigated the effect of this protease on cell migration and angiogenesis in vitro and studied the expression of meprin-α mRNA, protein and proteolytic activity in primary tumors at progressive stages and in liver metastases of patients with colorectal cancer, as well as inhibitory activity towards meprin-α in sera of cancer patient as compared to healthy controls. We found that the hepatocyte growth factor (HGF)- induced migratory response of meprin-transfected epithelial cells was increased compared to wild-type cells in the presence of plasminogen, and that the angiogenic response in organ-cultured rat aortic explants was enhanced in the presence of exogenous human meprin-α. In patients, meprin-α mRNA was expressed in colonic adenomas, primary tumors UICC (International Union Against Cancer) stage I, II, III and IV, as well as in liver metastases. In contrast, the corresponding protein accumulated only in primary tumors and liver metastases, but not in adenomas. However, liver metastases lacked meprin-α activity despite increased expression of the corresponding protein, which correlated with inefficient zymogen activation. Sera from cancer patients exhibited reduced meprin-α inhibition compared to healthy controls. In conclusion, meprin-α activity is regulated differently in primary tumors and metastases, leading to high proteolytic activity in primary tumors and low activity in liver metastases. By virtue of its pro-migratory and pro-angiogenic activity, meprin-α may promote tumor progression in colorectal cancer. [less ▲]

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See detailInterpretations of Polar Bear (Ursus maritimus) Tracks by Inuit Hunters: Inter-rater Reliability and Inferences Concerning Accuracy
Wong, Pamela; Van Coeverden de Groot, Peter; Fekken, Cynthia et al

in Canadian Field-Naturalist (2011), 125(2), 140-153

due to their tracking experience in pursuing Polar Bears (Ursus maritimus), Inuit hunters could provide non-invasive estimates of Polar Bear characteristics from tracks, and Polar Bear monitoring programs ... [more ▼]

due to their tracking experience in pursuing Polar Bears (Ursus maritimus), Inuit hunters could provide non-invasive estimates of Polar Bear characteristics from tracks, and Polar Bear monitoring programs could benefit from Inuit input. We determined i) inter-rater reliability of estimates of the sex, age, and size of Polar Bears, and estimates of the age of tracks made by a group of nine Inuit hunters who interpreted 78 tracks; ii) we made preliminary comparisons of sex and size estimates with conventional (scientific) estimates; iii) we catalogued the Polar Bear hunting experience and track interpretation techniques of nine Inuit hunters; and iv) we explored relationships between hunting experience and the ability to interpret tracks. The group of Inuit hunters made reliable and consistent estimates of Polar Bear sex, age, and size, as well as estimates of age of track (after data from one participant was excluded). Although our comparisons are based on small samples, our findings suggest that Inuit hunters may be accurate in estimating the sex of Polar Bears (74.42% agreement with genetic determinations) and the size of Polar Bears from their tracks. our data indicate shared tracking techniques used by hunters may explain high agreement in making specific estimates, while individual hunting experience and particular methods used to interpret tracks may lead to inter-rater reliability and accuracy in interpreting tracks. [less ▲]

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See detail10 façons d’interpréter une neuropathie asymétrique
WANG, François-Charles ULg

Conference (2011)

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See detailFunctional analysis of hydrogen photoproduction in respiratory-deficient mutants of Chlamydomonas reinhardtii
Lecler, Renaud ULg; Godaux, Damien ULg; Vigeolas, Hélène ULg et al

in International Journal of Hydrogen Energy (2011), 36

In this paper, mitochondrial mutants of Chlamydomonas reinhardtii defective for respiratory complex I (NADH:ubiquinone oxidoreductase), complex III (ubiquinol cytochrome c oxidoreductase) and both ... [more ▼]

In this paper, mitochondrial mutants of Chlamydomonas reinhardtii defective for respiratory complex I (NADH:ubiquinone oxidoreductase), complex III (ubiquinol cytochrome c oxidoreductase) and both complexes I and III were analyzed for H2 photoproduction. Several parameters were followed during the S-deficiency stage and the anaerobic stage leading to H2 photoproduction. At the early aerobic S-deficiency stage, starch and neutral lipids accumulated in all strains but their amount was significantly decreased in mutants compared to wild type. During the H2 photoproduction process, whereas starch content strongly decreased in all strains, neutral lipid amount remained nearly unchanged, suggesting that starch degraded by glycolysis is the preferential substrate for energy production during anaerobiosis. The mutants displayed a decrease in H2 photoproduction correlating to the number of active mitochondrial proton-pumping sites lost in the strains. Our results thus highlight the critical role of oxidative phosphorylation during the first (aerobic) stage of S-starvation when carbon resources are accumulated. [less ▲]

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See detailRapid effects of aggressive interactions on aromatase activity and oestradiol in discrete brain regions of wild male white-crowned sparrows
Charlier, Thierry ULg; Newman, Amy EM; Heimovics, Sarah A et al

in Journal of Neuroendocrinology (2011), 23

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See detailInfections à herpèsvirus chez les ruminants et les éléphants
Thiry, Etienne ULg; Thiry, J.

in Bulletin de l'Académie Vétérinaire de France (2011), 164

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See detailFossil bees and their plant associates
Michez, D.; Vanderplanck, Maryse ULg; Engel, M. S.

in Evolution of plant–pollinator relationships (2011)

The bees comprise a derived monophyletic group (Anthophila) of pollen-consuming (secondarily phytophagous) wasps of the superfamily Apoidea, and that diverged from a grade of predatory apoid wasps ... [more ▼]

The bees comprise a derived monophyletic group (Anthophila) of pollen-consuming (secondarily phytophagous) wasps of the superfamily Apoidea, and that diverged from a grade of predatory apoid wasps (formerly “Sphecidae”) sometime in the mid Cretaceous (∼120–125 megaannum) (Michener 1944, 1979, 2007; Brothers 1975, 1998; Alexander 1992; Ronquist 1999; Engel 2001a, 2011; Danforth et al. 2006). Seven contemporary families are usually acknowledged: Andrenidae, Apidae, Colletidae, Halictidae, Melittidae, Megachilidae and Stenotritidae, including ∼1200 genera and ∼20 000 species (Michener 2007; Engel 2005, 2011). Two fossil families are also described: Paleomelittidae from middle Eocene Baltic amber, and a stem-group, Melittosphecidae from Cretaceous Burmese amber which, as discussed below, may or may not be a bee (Engel 2001a; Poinar and Danforth 2006; Ohl and Engel 2007). Bees likely arose concomitantly with the diversification of flowering plants (angiosperms) (Michener 1979; Grimaldi 1999; Engel 1996, 2001a; Crepet et al. 2004; Grimaldi and Engel 2005). Represented by more than 250 000 described species, angiosperms are the most diversified group of vascular plants, covering nearly all terrestrial and many aquatic habitats (Soltis and Soltis 2004). The congruent rise of flowering plants and numerous phytophagous insect lineages, such as bees, ditrysian Lepidoptera, and various flowering-visiting beetles and flies, has fuelled the notion of coradiation between these lineages. Such a conclusion is supported by the observation of flowers with specific combinations of traits that are correlated with particular pollinators (Bronstein et al. 2006). Selection for insect-pollinated clades is also supported by the fact that deliverance by pollinators of unconsumed pollen to the host plant's female reproductive organs is clearly less stochastic and more efficient than alternative ancestral wind, water or gravity dispersive methods (Labandeira 1998). Lastly, association with pollinators increases opportunities for the evolution of specialization and subsequent diversification (Vamosi and Vamosi 2010). © The Systematics Association 2012. [less ▲]

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See detailInvolvement of z-MMP-2 in Zebrafish lymphangiogenesis
Paupert, Jenny ULg; Pendeville, Hélène; Detry, Benoît ULg et al

Conference (2011)

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See detailpi N transition distribution amplitudes: Their symmetries and constraints from chiral dynamics
Pire, Bernard; Semenov-Tyan-Shanskiy, Kirill ULg; Szymanowski, Lech

in Physical Review. D : Particles and Fields (2011), 84

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See detailWriting Gender, Re-writing Nation: Wide Sargasso Sea, Annie John, Jane and Louisa Will Soon Come Home, and Myal
Romdhani, Rebecca ULg

in Bucknor, Michael; Donnell, Alison (Eds.) The Routledge Companion to Anglophone Caribbean Literature (2011)

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See detailcompte rendu de : S. Douglas OLSON (Ed.), Athenaeus. The Learned Banqueters. Books 12-13.594b
Rochette, Bruno ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (2011), 80

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See detailKurt Smith, Matter Matters. Metaphysics and Methodology in the Early Modern Period
Dubouclez, Olivier ULg

in Bulletin cartésien (2011)

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See detailGobernabilidad desde las agrupaciones usuarias del agua con fines agrícolas en 8 municipios del territorio de la Mancomunidad de Municipios de la cuenca del río Naranjo (MANCUERNA)
Estrada Orozco, Nick Kenner ULg; Mux, Victor

in Tikalia (2011), XXIX(1-2), 37-46

En Guatemala, para alcanzar los Objetivos de desarrollo del Milenio se implemen- tan Programas Conjuntos con el apoyo del Sistema de Naciones Unidas. Existen en la actualidad cinco Programas Conjuntos ... [more ▼]

En Guatemala, para alcanzar los Objetivos de desarrollo del Milenio se implemen- tan Programas Conjuntos con el apoyo del Sistema de Naciones Unidas. Existen en la actualidad cinco Programas Conjuntos apoyando temas de seguridad alimen- taria, construcción de la paz, cambio climático, género y gobernabilidad económi- ca del agua. En el marco del programa conjunto: “Gobernabilidad económica en agua y sanea- miento” se decidió realizar un estudio que permitiera conocer la gobernabilidad en el sector a partir de hacer un inventario de las agrupaciones usuarias de agua con fines agrícolas y conocer algunas de sus características, este estudio contó con la asesoría técnica de la Organización de las Naciones Unidas para la Agricultura y la Alimentación –FAO– y el apoyo en campo de las comunidades asociadas por el agua y el medio ambiente de la cuenca del río Naranjo –CADISNA– en coordina- ción con el Ministerio de Agricultura Ganadería y Alimentación –MAGA– y go- biernos locales. El estudio se realizó en 8 municipios, 3 del departamento de Quetzaltenango y 5 de San Marcos, se identificaron 126 grupos de riego, de ellos, 73 pudieron ser carac- terizados. Se conoció que el 92% de los 73 grupos tiene una junta directiva que vela por el funcionamiento del sistema y la producción se ve diversificada en al menos 14 diferentes hortalizas siendo la principal el cultivo de la Papa. Sin embar- go sólo el 45% paga una tarifa a su grupo y el 60% de los usuarios necesita crédito para poder producir, haciendo uso de al menos 271.99 Lts/seg de agua para fines agrícolas. [less ▲]

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See detailA study of institutional environment and household food security at local level in Rwanda
Mathai, Jose A.; Musabanganji, Edouard ULg; Niwemahoro, Celine et al

in Rwanda Journal (2011), 22(Série B : Social Sciences), 96-128

The study looked into the current scenario of food security in Rwanda. After analysing the national level institutional and food security scenarios by using available secondary data, the researchers used ... [more ▼]

The study looked into the current scenario of food security in Rwanda. After analysing the national level institutional and food security scenarios by using available secondary data, the researchers used primary data that have been collected from a random sample of 200 households spreading over six sectors of the Huye district by using structured interview schedule, as well using a case study of a rice cooperative in Huye district. Focus group discussions with all stake holders concerned with food security at local level enriched the data that we collected by other means. The general conclusion that emerges from the study is that in order to attain the food security at local level in Rwanda lot more to be done. Among other things, strengthening existing local institutions like farmer cooperatives, improving agricultural production technology, diversifying household income sources for better access, and genuine integration of food security concerns in the district development plans. The researchers come out with certain policy recommendations that may make the local level food security more sustainable which includes, among others, the orientation of the households well into the new modes of agricultural production and planning of household income. The need for much more local level institutional support in many areas is highlighted. On the whole, the study addressed the concerns of food access among rural households in Rwanda, and also the much wanted institutional support being exposed. [less ▲]

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See detailQuantifying hyporheic exchange at high spatial resolution using natural temperature variations along a first order stream
Westhoff, Martijn ULg; Gooseff, M. N.; Bogaard, T. A. et al

in Water Resources Research (2011), 47

Hyporheic exchange is an important process that underpins stream ecosystem function, and there have been numerous ways to characterize and quantify exchange flow rates and hyporheic zone size. The most ... [more ▼]

Hyporheic exchange is an important process that underpins stream ecosystem function, and there have been numerous ways to characterize and quantify exchange flow rates and hyporheic zone size. The most common approach, using conservative stream tracer experiments and 1-D solute transport modeling, results in oversimplified representations of the system. Here we present a new approach to quantify hyporheic exchange and the size of the hyporheic zone (HZ) using high-resolution temperature measurements and a coupled 1-D transient storage and energy balance model to simulate in-stream water temperatures. Distributed temperature sensing was used to observe in-stream water temperatures with a spatial and temporal resolution of 2 and 3 min, respectively. The hyporheic exchange coefficient (which describes the rate of exchange) and the volume of the HZ were determined to range between 0 and 2.7 × 10−3 s−1 and 0 and 0.032 m3 m−1, respectively, at a spatial resolution of 1–10 m, by simulating a time series of in-stream water temperatures along a 565 m long stretch of a small first-order stream in central Luxembourg. As opposed to conventional stream tracer tests, two advantages of this approach are that exchange parameters can be determined for any stream segment over which data have been collected and that the depth of the HZ can be estimated as well. Although the presented method was tested on a small stream, it has potential for any stream where rapid (in regard to time) temperature change of a few degrees can be obtained. [less ▲]

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See detailMultiparametric observation and analysis of the Sea
Alvera Azcarate, Aïda ULg; Poulain, Pierre-Marie

in Ocean Dynamics (2011)

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See detailLarge carrion beetles (Coleoptera, Silphidae) in Western Europe: a review
Dekeirsschieter, Jessica ULg; Verheggen, François ULg; Lognay, Georges ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2011), 15(3), 425-437

This review focuses on carrion beetles (Coleoptera, Silphidae) of the Western Palearctic and their potential use in forensic entomology as bioindicators. Few studies have looked at Silphidae in forensic ... [more ▼]

This review focuses on carrion beetles (Coleoptera, Silphidae) of the Western Palearctic and their potential use in forensic entomology as bioindicators. Few studies have looked at Silphidae in forensic context and investigations. However, some Silphidae present the desirable characteristics of some Diptera used in postmortem estimates and thus may extend the minimum postmortem interval (PMImin). We review here the taxonomy and distribution of Western Palearctic Silphidae. The anatomical and morphological characteristics of both subfamilies are described for adults and larvae. The biology and ecology of silphids are also summarized for Silphinae and Nicrophorinae. A specific chapter gives an overview of the current uses of Silphidae in forensic entomology as postmortem indicator. [less ▲]

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