References of "2011"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailEffects of monopropanediamino-beta-cyclodextrin on the denaturation process of the hybrid protein BlaPChBD.
Vandevenne, Marylène ULg; GASPARD, Genevieve ULg; Belgsir, E. M. et al

in Biochimica et biophysica acta (2011)

Irreversible accumulation of protein aggregates represents an important problem both in vivo and in vitro. The aggregation of proteins is of critical importance in a wide variety of biomedical situations ... [more ▼]

Irreversible accumulation of protein aggregates represents an important problem both in vivo and in vitro. The aggregation of proteins is of critical importance in a wide variety of biomedical situations, ranging from diseases (such as Alzheimer's and Parkinson's diseases) to the production (e.g. inclusion bodies), stability, storage and delivery of protein drugs. beta-Cyclodextrin (beta-CD) is a circular heptasaccharide characterized by a hydrophilic exterior and a hydrophobic interior ring structure. In this research, we studied the effects of a chemically modified beta-CD (BCD07056), on the aggregating and refolding properties of BlaPChBD, a hybrid protein obtained by inserting the chitin binding domain of the human macrophage chitotriosidase into the class A beta-lactamase BlaP from Bacillus licheniformis 749/I during its thermal denaturation. The results show that BCD07056 strongly increases the refolding yield of BlaPChBD after thermal denaturation and constitutes an excellent additive to stabilize the protein over time at room temperature. Our data suggest that BCD07056 acts early in the denaturation process by preventing the formation of an intermediate which leads to an aggregated state. Finally, the role of beta-CD derivatives on the stability of proteins is discussed. [less ▲]

Detailed reference viewed: 65 (9 ULg)
Full Text
Peer Reviewed
See detailEpidemiology of pestivirus infection in wild ungulates of the French South Alps
Martin, C.; Letellier, C.; Caij, B. et al

in Veterinary Microbiology (2011), 147(3-4), 320-328

Detailed reference viewed: 35 (18 ULg)
Full Text
Peer Reviewed
See detailImpact of chronic graft-versus-host disease (GVHD) after reduced intensity conditioning (RIC) allogeneic stem cell transplantation (allo-SCT) as treatment for acute myeloid leukemia (AML) : a survey from the Acute Leukemia Working Party of the EBMT
Baron, Frédéric ULg; Labopin, Myriam; Niederwieser, Dietger et al

in Blood (2011), 118

The goal of RIC allo-SCT is to harness the graft-versus-leukemia (GVL) effect, while minimizing toxicities and the risk of GVHD. However, prior studies have shown a lower risk of relapse in AML patients ... [more ▼]

The goal of RIC allo-SCT is to harness the graft-versus-leukemia (GVL) effect, while minimizing toxicities and the risk of GVHD. However, prior studies have shown a lower risk of relapse in AML patients (pts) who experienced chronic GVHD after RIC allo-SCT versus in those who did not. Here, we investigated the impact of occurrence of GVHD on transplantation outcomes in a large cohort of AML pts given allogeneic PBSC after RIC conditioning. Data from 1859 AML pts in first (n=1439) or second (n=420) CR transplanted between 2000 and 2009 following a RIC regimen at EBMT affiliated centres were analyzed. Pts were given PBSC from HLA-identical sibling (MRD, n=1208), or from HLA-matched unrelated donors (MUD, n=651). Median pt age at transplantation was 56 y (range, 18–77). 338 male pts were given grafts from female donors. RIC was based on low-dose TBI in 520 (28%) pts, while the remaining pts received chemotherapy-based RIC. ATG was given in 269 (22%) MRD and in 267 (41%) MUD recipients, respectively, while 151 (13%) MRD and 165 (25%) MUD recipients received in-vivo T cell depletion with alemtuzumab. The impact of chronic GVHD on relapse risk, non-relapse mortality (NRM), leukemia-free survival (LFS), and overall survival (OS) was assessed using time-dependent multivariate Cox models and in a landmark analysis at 18 months after transplant. Three-year incidences of relapse, NRM, LFS and OS were 34±1%, 15±1%, 51±2% and 60±2% in MRD recipients, respectively, and 34±2% (p=NS), 24±2% (P<0.001), 42±2% (P=0.001) and 47±2% (P=0.001) in MUD recipients, respectively. Grade II, III and IV acute GVHD were observed in 133 (11%), 61 (5%) and 30 (2%) MRD recipients and in 119 (18%), 41 (6%) and 24 (4%) MUD recipients, respectively. The 3-y cumulative incidence of chronic GVHD was 47%. Fifty-three percent of patients with chronic GVHD had extensive chronic GVHD, while the remaining 47% had limited chronic GVHD. In multivariate analyses, occurrence of grade II-IV acute GVHD was associated with a lower risk of relapse (HR=0.8; P=0.04), a higher risk of chronic (HR=2.2; P<0.001) and extensive chronic GVHD (HR=2.8; P<0.001), a higher risk of NRM (HR=2.4 P<0.001), a worsened LFS (HR=1.3; P=0.01), and a worsened OS (HR=1.5; P<0.001). In multivariate time-dependent analyses, occurrence of limited chronic GVHD was associated with a lower risk of relapse (HR=0.7; P=0.05), comparable NRM (HR=1.4; P=0.16), comparable LFS (HR=0.9; P=0.29) and better OS (HR=0.5; P<0.001), while occurrence of extensive chronic GVHD was associated with a lower risk of relapse (HR=0.6; P=0.01), higher NRM (HR=3.2; P<0.001), a trend for worsened LFS (HR=1.3; P=0.06) and comparable OS (HR=0.9; P=0.34). The median interval from transplantation to occurrence of chronic GVHD was 163 (range, 100–1545) days. To further assess the graft-versus-leukemia effect of chronic GVHD, we performed a landmark analysis in patients who were leukemia-free at 18 months after transplantation (n=776). Median follow-up from this landmark time-point was 24 (range, 0.1–112) months. Two-year relapse, NRM, LFS and OS were 16±2%, 2.5±1%, 82±2%, and 89±2%, respectively, in patients without chronic GVHD before the landmark time-point, versus 9±1% (P=0.001), 8±1% (P<0.001), 83±2% (P=0.65), and 86±2% (P=0.38), respectively, in patients with chronic GVHD before the landmark time-point.In conclusion, in this cohort of AML patients transplanted in remission, occurrence of chronic GVHD was associated with a lower risk of relapse that translated to better OS in patients with limited chronic GVHD but not in those with extensive chronic GVHD who experienced higher long term NRM, highlighting the need for long term prospective assessment of long term effects and quality of life in patients receiving RIC allo-SCT. [less ▲]

Detailed reference viewed: 66 (2 ULg)
Full Text
Peer Reviewed
See detailSource parameters of the 2008 Bukavu-Cyangugu earthquake estimated from InSAR and teleseismic data
d'Oreye, Nicolas; Gonzalez, P.; Shuler, A. et al

in Geophysical Journal International (2011)

Detailed reference viewed: 27 (8 ULg)
Full Text
Peer Reviewed
See detailDie Narrenburg im Waldwinkel. Theodor Storms Auseinandersetzung mit Adalbert Stifter
Leyh, Valérie ULg

in Sprachkunst. Beiträge zur Literaturwissenschaft (2011), 42(1), 1-28

Comme l'ont déjà évoqué plusieurs chercheurs, la nouvelle "Waldwinkel" (1874) de Theodor Storm montre de nombreuses correspondances avec le récit "Die Narrenburg" (1842) d'Adalbert Stifter. Or jusqu'à ... [more ▼]

Comme l'ont déjà évoqué plusieurs chercheurs, la nouvelle "Waldwinkel" (1874) de Theodor Storm montre de nombreuses correspondances avec le récit "Die Narrenburg" (1842) d'Adalbert Stifter. Or jusqu'à présent, ce rapport étroit entre ces deux textes narratifs n'a pas encore été étudié en profondeur. Cet article vise dès lors à analyser les continuités et discontinuités entre ces deux récits. Une étude minutieuse des stratégies narratives ainsi qu'une analyse comparative des personnages principaux permettent de constater que la nouvelle de Storm fait, certes, renaître le monde de Stifter, mais pour le faire apparaître comme un non-lieu, une utopie. La noblesse, qui chez Stifter parvient encore à se renouveler en s'alliant à la bourgeoisie, est ainsi, chez Storm, vouée au déclin. Le monde représenté dans "Waldwinkel" est, quant à lui, marqué par la réalité du capitalisme et du combat de tous contre tous. [less ▲]

Detailed reference viewed: 81 (10 ULg)
Full Text
See detailEtude de l'activité antifongique des bactéries lactiques isolées de produits alimentaires fermentés et caractérisation de leurs métabolites inhibiteurs
Ndagano, Dora ULg

Doctoral thesis (2011)

Summary: The aim of this present research was to study the antifungal properties of lactic acid bacteria (LAB) isolated from fermented Mill flour and fermented cassava in order to use them for ... [more ▼]

Summary: The aim of this present research was to study the antifungal properties of lactic acid bacteria (LAB) isolated from fermented Mill flour and fermented cassava in order to use them for biopreservation. Antifungal activity of these LAB were assessed in MRS solid medium against food spoilage moulds as Aspergillus niger MUCL 28699, Aspergillus niger CWBIF194, Aspergillus tubingensis MP1 and Penicillium crustosum MY1. Three strains, Lactobacillus plantarum VE56, Weissella cibaria FMF4B16 and Weissella paramesenteroides LC11 were selected among 116 for their strongest inhibitory activity and their broad inhibitory spectrum against food moulds. The 4-fold concentrated supernatant of L. plantarum VE56 and W. paramesenteroides LC11 had the strongest inhibitory activity to compare to W. cibaria FMF4B16. The antifungal activity of the cell-free supernatant was pH dependent and insensitive to proteolytic enzymes action suggesting that the inhibitory activity was due to other compounds than proteins. The identification of antifungal compounds by chromatographic studies highlighted the production of phenyllactic acid by the three strains. In addition, 2-hydroxy-3-methylpentanoic acid and 2-hydroxy-4-methylpentanoic acid were produced by L. plantarum VE56 and W. paramesenteroides LC11. However, the concentration assessed in the supernatant was lower than the minimal inhibitory concentration showing a synergic action of all these produced compounds. The effect of the antifungal supernatant of L. plantarum VE56 and W. paramesenteroides LC11 on Aspergillus flavus NRRL 3357 resulted to an inhibition of conidial development and aflatoxin B1 production which was reflected in decreased gene expression of brlA (conidiophore specific transcription factor) and laeA (global regulator of secondary metabolism). These two bacteria also delayed Penicillium expansum MUCL 14498 conidial development in bread. [less ▲]

Detailed reference viewed: 424 (20 ULg)
Full Text
Peer Reviewed
See detailActors' benefit analysis on value chain of fresh dairy milk in Vietnam
Tran Huu; Bui, Thi Nga ULg

in Journal of Economics & Development (2011), (169(II)), 32-38

Vietnam locates in the Asia-the most active region, where gains the highest economic growth rate and highest milk consumption in the world. Vietnam also ranks the second among the highest milk ... [more ▼]

Vietnam locates in the Asia-the most active region, where gains the highest economic growth rate and highest milk consumption in the world. Vietnam also ranks the second among the highest milk productivity in the Asia and milk consumption is increasing rapidly. However, the dairy industry in Vietnam is currently able to meet only 22% of domestic demand; the remaining amount has been imported (VOV/VNA, 2008). In addition, raw milk price is very low while retail price is too high. It leads to low effective in the production of the whole chain. This paper is based on the value chain approach within both quantitative and qualitative methods to evaluate a typical fresh value chain in the North of Vietnam in (Moc Chau platation) in 2008 - 2010. The findings show that the dairy plant is the most powerful actor in the chain and it drives the whole chain while power of dairymen is very weak. The value added of the chain is distributed unequally among its actors in whom more benefitable for non-dairy cow producers. In particular, the value added in dairy cow stage would be much lower. [less ▲]

Detailed reference viewed: 214 (10 ULg)
Full Text
Peer Reviewed
See detailA naming convention for the Piano Key Weirs geometrical parameters
Pralong, Julien; Vermeulen, Julien; Blancher, Benoit et al

in Erpicum, Sébastien; Laugier, Frédérique; Boillat, Jean-Louis (Eds.) et al Labyrinth and Piano Key Weirs - PKW 2011 (2011)

Flood management is more than ever an issue for dam designers and engineering consulting firms in charge of rehabilitation works. Piano Key Weirs are a new cost-effective type of spillway designed to ... [more ▼]

Flood management is more than ever an issue for dam designers and engineering consulting firms in charge of rehabilitation works. Piano Key Weirs are a new cost-effective type of spillway designed to improve dams discharge capacity. These structures are particularly attractive: they can easily be built on existing structures and enable very high discharge capacities. Therefore, Piano Key Weirs are nowadays studied worldwide. Piano Key Weir description involves a lot of geometrical parameters (more than 30), which designations are not already universally defined. A naming convention is required to enhance exchanges and cooperation between the numerous developers. A naming convention has been developed at EDF – Hydro Engineering Center in cooperation with the Laboratory of Hydraulic Constructions (LCH), Ecole Polytechnique Fédérale de Lausanne and the Laboratory of Hydrology, Applied Hydrodynamics and Hydraulic Constructions (HACH), University of Liege. This paper describes the proposed naming convention and gives definitions and notations of the various geometrical parameters. This work represents a first attempt which should be updated with the contribution of stakeholders involved in this topic. [less ▲]

Detailed reference viewed: 243 (7 ULg)
See detailOnderneming en recht. Bedrijfsfiscaliteit
Peeters, Bart ULg

Book published by Knops Publishing (2011)

Detailed reference viewed: 26 (0 ULg)
Full Text
Peer Reviewed
See detailBespreking HvJ 18 maart 2010
Peeters, Bart ULg

in Rechtskundig Weekblad (2011)

Detailed reference viewed: 9 (1 ULg)
Full Text
See detailTraumatologie du golf
Kaux, Jean-François ULg; Crielaard, Jean-Michel ULg

Learning material (2011)

Detailed reference viewed: 169 (20 ULg)
Full Text
Peer Reviewed
See detailLa main de Gilliatt-Sumner ou le syndrome de défilé cervicothoracique neurogène vrai. A propos de sept cas opérés.
DUBUISSON, Annie ULg; NGUYEN KHAC, Minh-Tuan ULg; SCHOLTES, Félix ULg et al

in Neuro-Chirurgie (2011), 57(1), 9-14

BACKGROUND AND PURPOSE: The clinical picture of hand atrophy related to a cervical rib or elongated C7 transverse process was well described in the modern literature by Gilliatt and Sumner; in 1970, they ... [more ▼]

BACKGROUND AND PURPOSE: The clinical picture of hand atrophy related to a cervical rib or elongated C7 transverse process was well described in the modern literature by Gilliatt and Sumner; in 1970, they reported a series of nine patients whose motor status was stabilized following brachial plexus decompression. We report here seven patients suffering from thoracic outlet syndrome (TOS), who developed hand atrophy, sometimes because of diagnostic delay. METHODS: The patient's charts were analysed retrospectively. RESULTS: The seven patients were all female; the mean age was 43 years. The first complaints were arm pain and paresthesias lasting six months to 5 years. Three patients were treated with C56/C67 discectomy plus disc prosthesis (one patient), ulnar neurolysis at the elbow (the same patient), carpal tunnel release (one patient), and intravenous immunoglobulins (one patient) before TOS diagnosis. Hand atrophy, severe in five patients, was present at presentation. All patients underwent brachial plexus decompression by the anterior (four), posterior (two), or transaxillary (one) approach. This last approach was completed 18 months later by brachial plexus neurolysis via the anterior approach. Postoperatively, motor deficit was improved in two patients and stabilized in five patients. CONCLUSIONS: Physicians' unfamiliarity with TOS diagnosis or their reluctance to accept the diagnosis without electrical confirmation can lead to hand atrophy. Brachial plexus decompression at this stage usually stabilizes the deficit. [less ▲]

Detailed reference viewed: 46 (7 ULg)
See detailMaîtrise de la situation d’enseignement-apprentissage et savoirs professionnels des futurs enseignants
Beckers, Jacqueline ULg

in Maubant, Philippe; Martineau, Stéphane (Eds.) Fondements des pratiques professionnelles des enseignants (2011)

Detailed reference viewed: 40 (7 ULg)
Full Text
See detailMarket integration: trade vs. economic geography
Tharakan, Joseph ULg; Thisse, Jacques

in Jovanovic, Miroslav (Ed.) International Handbook on the Economics of Integration (2011)

Detailed reference viewed: 78 (15 ULg)
Full Text
Peer Reviewed
See detailThree-dimensional void space structure of activated carbon packed beds
Almazan Almazan, Maria Del Carmen; Léonard, Angélique ULg; Job, Nathalie ULg et al

in Journal of Porous Materials (2011), 18

Detailed reference viewed: 52 (10 ULg)