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See detailImpact of chronic graft-versus-host disease (GVHD) after reduced intensity conditioning (RIC) allogeneic stem cell transplantation (allo-SCT) as treatment for acute myeloid leukemia (AML) : a survey from the Acute Leukemia Working Party of the EBMT
Baron, Frédéric ULg; Labopin, Myriam; Niederwieser, Dietger et al

in Blood (2011), 118

The goal of RIC allo-SCT is to harness the graft-versus-leukemia (GVL) effect, while minimizing toxicities and the risk of GVHD. However, prior studies have shown a lower risk of relapse in AML patients ... [more ▼]

The goal of RIC allo-SCT is to harness the graft-versus-leukemia (GVL) effect, while minimizing toxicities and the risk of GVHD. However, prior studies have shown a lower risk of relapse in AML patients (pts) who experienced chronic GVHD after RIC allo-SCT versus in those who did not. Here, we investigated the impact of occurrence of GVHD on transplantation outcomes in a large cohort of AML pts given allogeneic PBSC after RIC conditioning. Data from 1859 AML pts in first (n=1439) or second (n=420) CR transplanted between 2000 and 2009 following a RIC regimen at EBMT affiliated centres were analyzed. Pts were given PBSC from HLA-identical sibling (MRD, n=1208), or from HLA-matched unrelated donors (MUD, n=651). Median pt age at transplantation was 56 y (range, 18–77). 338 male pts were given grafts from female donors. RIC was based on low-dose TBI in 520 (28%) pts, while the remaining pts received chemotherapy-based RIC. ATG was given in 269 (22%) MRD and in 267 (41%) MUD recipients, respectively, while 151 (13%) MRD and 165 (25%) MUD recipients received in-vivo T cell depletion with alemtuzumab. The impact of chronic GVHD on relapse risk, non-relapse mortality (NRM), leukemia-free survival (LFS), and overall survival (OS) was assessed using time-dependent multivariate Cox models and in a landmark analysis at 18 months after transplant. Three-year incidences of relapse, NRM, LFS and OS were 34±1%, 15±1%, 51±2% and 60±2% in MRD recipients, respectively, and 34±2% (p=NS), 24±2% (P<0.001), 42±2% (P=0.001) and 47±2% (P=0.001) in MUD recipients, respectively. Grade II, III and IV acute GVHD were observed in 133 (11%), 61 (5%) and 30 (2%) MRD recipients and in 119 (18%), 41 (6%) and 24 (4%) MUD recipients, respectively. The 3-y cumulative incidence of chronic GVHD was 47%. Fifty-three percent of patients with chronic GVHD had extensive chronic GVHD, while the remaining 47% had limited chronic GVHD. In multivariate analyses, occurrence of grade II-IV acute GVHD was associated with a lower risk of relapse (HR=0.8; P=0.04), a higher risk of chronic (HR=2.2; P<0.001) and extensive chronic GVHD (HR=2.8; P<0.001), a higher risk of NRM (HR=2.4 P<0.001), a worsened LFS (HR=1.3; P=0.01), and a worsened OS (HR=1.5; P<0.001). In multivariate time-dependent analyses, occurrence of limited chronic GVHD was associated with a lower risk of relapse (HR=0.7; P=0.05), comparable NRM (HR=1.4; P=0.16), comparable LFS (HR=0.9; P=0.29) and better OS (HR=0.5; P<0.001), while occurrence of extensive chronic GVHD was associated with a lower risk of relapse (HR=0.6; P=0.01), higher NRM (HR=3.2; P<0.001), a trend for worsened LFS (HR=1.3; P=0.06) and comparable OS (HR=0.9; P=0.34). The median interval from transplantation to occurrence of chronic GVHD was 163 (range, 100–1545) days. To further assess the graft-versus-leukemia effect of chronic GVHD, we performed a landmark analysis in patients who were leukemia-free at 18 months after transplantation (n=776). Median follow-up from this landmark time-point was 24 (range, 0.1–112) months. Two-year relapse, NRM, LFS and OS were 16±2%, 2.5±1%, 82±2%, and 89±2%, respectively, in patients without chronic GVHD before the landmark time-point, versus 9±1% (P=0.001), 8±1% (P<0.001), 83±2% (P=0.65), and 86±2% (P=0.38), respectively, in patients with chronic GVHD before the landmark time-point.In conclusion, in this cohort of AML patients transplanted in remission, occurrence of chronic GVHD was associated with a lower risk of relapse that translated to better OS in patients with limited chronic GVHD but not in those with extensive chronic GVHD who experienced higher long term NRM, highlighting the need for long term prospective assessment of long term effects and quality of life in patients receiving RIC allo-SCT. [less ▲]

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See detailOutcome of pregnancy in women with inflammatory bowel disease treated with antitumor necrosis factor therapy.
Schnitzler, François ULg; Fidder, Herma; Boukerroucha, Meriem ULg et al

in Inflammatory Bowel Diseases (2011), 17(9), 1846-1854

BACKGROUND:: Infliximab (IFX) and adalimumab (ADA) are attractive treatment options in patients with inflammatory bowel disease (IBD) also during pregnancy but there is still limited data on the benefit ... [more ▼]

BACKGROUND:: Infliximab (IFX) and adalimumab (ADA) are attractive treatment options in patients with inflammatory bowel disease (IBD) also during pregnancy but there is still limited data on the benefit/risk profile of IFX and ADA during pregnancy. METHODS:: This observational study assessed pregnancy outcomes in 212 women with IBD under antitumor necrosis factor alpha (TNF) treatment at our IBD unit. Pregnancy outcomes in 42 pregnancies with direct exposure to anti-TNF treatment (35 IFX, 7 ADA) were compared with that in 23 pregnancies prior to IBD diagnosis, 78 pregnancies before start of IFX, 53 pregnancies with indirect exposure to IFX, and 56 matched pregnancies in healthy women. RESULTS:: Thirty-two of the 42 pregnancies ended in live births with a median gestational age of 38 weeks (interquartile range [IQR] 37-39). There were seven premature deliveries, six children had low birth weight, and there was one stillbirth. One boy weighed 1640 g delivered at week 33, died at age of 13 days because of necrotizing enterocolitis. A total of eight abortions (one patient wish) occurred in seven women. Trisomy 18 was diagnosed in one fetus of a mother with CD at age 37 under ADA treatment (40 mg weekly) and pregnancy was terminated. Pregnancy outcomes after direct exposure to anti-TNF treatment were not different from those in pregnancies before anti-TNF treatment or with indirect exposure to anti-TNF treatment but outcomes were worse than in pregnancies before IBD diagnosis. CONCLUSIONS:: Direct exposure to anti-TNF treatment during pregnancy was not related to a higher incidence of adverse pregnancy outcomes than IBD overall. (Inflamm Bowel Dis 2011;). [less ▲]

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See detailHet geïntegreerde contrastieve onderzoeksdesign onder de loep
Hiligsmann, Philippe; Rasier, Laurent ULg

in Rasier, Laurent; Van Heuven, Vincent; Defrancq, Bart (Eds.) et al Nederlands in het perspectief van uitspraakverwerving en contrastieve taalkunde (2011)

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See detailEtude de l'activité antifongique des bactéries lactiques isolées de produits alimentaires fermentés et caractérisation de leurs métabolites inhibiteurs
Ndagano, Dora ULg

Doctoral thesis (2011)

Summary: The aim of this present research was to study the antifungal properties of lactic acid bacteria (LAB) isolated from fermented Mill flour and fermented cassava in order to use them for ... [more ▼]

Summary: The aim of this present research was to study the antifungal properties of lactic acid bacteria (LAB) isolated from fermented Mill flour and fermented cassava in order to use them for biopreservation. Antifungal activity of these LAB were assessed in MRS solid medium against food spoilage moulds as Aspergillus niger MUCL 28699, Aspergillus niger CWBIF194, Aspergillus tubingensis MP1 and Penicillium crustosum MY1. Three strains, Lactobacillus plantarum VE56, Weissella cibaria FMF4B16 and Weissella paramesenteroides LC11 were selected among 116 for their strongest inhibitory activity and their broad inhibitory spectrum against food moulds. The 4-fold concentrated supernatant of L. plantarum VE56 and W. paramesenteroides LC11 had the strongest inhibitory activity to compare to W. cibaria FMF4B16. The antifungal activity of the cell-free supernatant was pH dependent and insensitive to proteolytic enzymes action suggesting that the inhibitory activity was due to other compounds than proteins. The identification of antifungal compounds by chromatographic studies highlighted the production of phenyllactic acid by the three strains. In addition, 2-hydroxy-3-methylpentanoic acid and 2-hydroxy-4-methylpentanoic acid were produced by L. plantarum VE56 and W. paramesenteroides LC11. However, the concentration assessed in the supernatant was lower than the minimal inhibitory concentration showing a synergic action of all these produced compounds. The effect of the antifungal supernatant of L. plantarum VE56 and W. paramesenteroides LC11 on Aspergillus flavus NRRL 3357 resulted to an inhibition of conidial development and aflatoxin B1 production which was reflected in decreased gene expression of brlA (conidiophore specific transcription factor) and laeA (global regulator of secondary metabolism). These two bacteria also delayed Penicillium expansum MUCL 14498 conidial development in bread. [less ▲]

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See detailActors' benefit analysis on value chain of fresh dairy milk in Vietnam
Tran Huu; Bui, Thi Nga ULg

in Journal of Economics & Development (2011), (169(II)), 32-38

Vietnam locates in the Asia-the most active region, where gains the highest economic growth rate and highest milk consumption in the world. Vietnam also ranks the second among the highest milk ... [more ▼]

Vietnam locates in the Asia-the most active region, where gains the highest economic growth rate and highest milk consumption in the world. Vietnam also ranks the second among the highest milk productivity in the Asia and milk consumption is increasing rapidly. However, the dairy industry in Vietnam is currently able to meet only 22% of domestic demand; the remaining amount has been imported (VOV/VNA, 2008). In addition, raw milk price is very low while retail price is too high. It leads to low effective in the production of the whole chain. This paper is based on the value chain approach within both quantitative and qualitative methods to evaluate a typical fresh value chain in the North of Vietnam in (Moc Chau platation) in 2008 - 2010. The findings show that the dairy plant is the most powerful actor in the chain and it drives the whole chain while power of dairymen is very weak. The value added of the chain is distributed unequally among its actors in whom more benefitable for non-dairy cow producers. In particular, the value added in dairy cow stage would be much lower. [less ▲]

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See detailNucleolar structure across evolution: the transition between bi- and tri-compartmentalized nucleoli lies within the class Reptilia.
Lamaye, Francoise; Galliot, Sonia; Alibardi, Lorenzo et al

in Journal of Structural Biology (2011), 174(2), 352-9

Two types of nucleolus can be distinguished among eukaryotic cells: a tri-compartmentalized nucleolus in amniotes and a bi-compartmentalized nucleolus in all the others. However, though the nucleolus ... [more ▼]

Two types of nucleolus can be distinguished among eukaryotic cells: a tri-compartmentalized nucleolus in amniotes and a bi-compartmentalized nucleolus in all the others. However, though the nucleolus' ultrastructure is well characterized in mammals and birds, it has been so far much less studied in reptiles. In this work, we examined the ultrastructural organization of the nucleolus in various tissues from different reptilian species (three turtles, three lizards, two crocodiles, and three snakes). Using cytochemical and immunocytological methods, we showed that in reptiles both types of nucleolus are present: a bi-compartmentalized nucleolus in turtles and a tri-compartmentalized nucleolus in the other species examined in this study. Furthermore, in a given species, the same type of nucleolus is present in all the tissues, however, the importance and the repartition of those nucleolar components could vary from one tissue to another. We also reveal that, contrary to the mammalian nucleolus, the reptilian fibrillar centers contain small clumps of condensed chromatin and that their surrounding dense fibrillar component is thicker. Finally, we also report that Cajal bodies are detected in reptiles. Altogether, we believe that these results have profound evolutionarily implications since they indicate that the point of transition between bipartite and tripartite nucleoli lies at the emergence of the amniotes within the class Reptilia. [less ▲]

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See detailOnderneming en recht. Bedrijfsfiscaliteit
Peeters, Bart ULg

Book published by Knops Publishing (2011)

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See detailBespreking HvJ 18 maart 2010
Peeters, Bart ULg

in Rechtskundig Weekblad (2011)

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See detailTraumatologie du golf
Kaux, Jean-François ULg; Crielaard, Jean-Michel ULg

Learning material (2011)

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See detailLa main de Gilliatt-Sumner ou le syndrome de défilé cervicothoracique neurogène vrai. A propos de sept cas opérés.
DUBUISSON, Annie ULg; NGUYEN KHAC, Minh-Tuan ULg; SCHOLTES, Félix ULg et al

in Neuro-Chirurgie (2011), 57(1), 9-14

BACKGROUND AND PURPOSE: The clinical picture of hand atrophy related to a cervical rib or elongated C7 transverse process was well described in the modern literature by Gilliatt and Sumner; in 1970, they ... [more ▼]

BACKGROUND AND PURPOSE: The clinical picture of hand atrophy related to a cervical rib or elongated C7 transverse process was well described in the modern literature by Gilliatt and Sumner; in 1970, they reported a series of nine patients whose motor status was stabilized following brachial plexus decompression. We report here seven patients suffering from thoracic outlet syndrome (TOS), who developed hand atrophy, sometimes because of diagnostic delay. METHODS: The patient's charts were analysed retrospectively. RESULTS: The seven patients were all female; the mean age was 43 years. The first complaints were arm pain and paresthesias lasting six months to 5 years. Three patients were treated with C56/C67 discectomy plus disc prosthesis (one patient), ulnar neurolysis at the elbow (the same patient), carpal tunnel release (one patient), and intravenous immunoglobulins (one patient) before TOS diagnosis. Hand atrophy, severe in five patients, was present at presentation. All patients underwent brachial plexus decompression by the anterior (four), posterior (two), or transaxillary (one) approach. This last approach was completed 18 months later by brachial plexus neurolysis via the anterior approach. Postoperatively, motor deficit was improved in two patients and stabilized in five patients. CONCLUSIONS: Physicians' unfamiliarity with TOS diagnosis or their reluctance to accept the diagnosis without electrical confirmation can lead to hand atrophy. Brachial plexus decompression at this stage usually stabilizes the deficit. [less ▲]

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See detailLe Moyen Âge. Revue d'histoire et de philologie
Marchandisse, Alain ULg; Dumont, Jonathan ULg

Book published by De Boeck (2011)

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See detailLattice dynamics in the FeSb3 skutterudite
Moechel, A.; Sergueev, I.; Long, Gary J. et al

in Physical Review (2011), 84(6),

Thin films of FeSb3 were characterized by electronic transport magnetometry, x-ray diffraction, Fe-57 and Sb-121 nuclear inelastic scattering, and Fe-57 Mossbauer spectroscopy. Resistivity and ... [more ▼]

Thin films of FeSb3 were characterized by electronic transport magnetometry, x-ray diffraction, Fe-57 and Sb-121 nuclear inelastic scattering, and Fe-57 Mossbauer spectroscopy. Resistivity and magnetometry measurements reveal semiconducting behavior with a 16.3(4) meV band gap and an effective paramagnetic moment of 0.57(6) mu(B) respectively. A systematic comparison of the lattice dynamics with CoSb3 and EuFe4Sb12 reveals that the Fe4Sb12 framework is softer than the Co4Sb12 framework, and that the observed softening and the associated lowering of the lattice thermal conductivity in the RFe4Sb12 filled skutterudites are not only related to the filler but also to the Fe4Sb12 framework. [less ▲]

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See detailResequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease.
Momozawa, Yukihide ULg; Mni, Myriam ULg; Nakamura, Kayo ULg et al

in Nature Genetics (2011), 43(1), 43-7

Genome-wide association studies (GWAS) have identified dozens of risk loci for many complex disorders, including Crohn's disease. However, common disease-associated SNPs explain at most approximately 20 ... [more ▼]

Genome-wide association studies (GWAS) have identified dozens of risk loci for many complex disorders, including Crohn's disease. However, common disease-associated SNPs explain at most approximately 20% of the genetic variance for Crohn's disease. Several factors may account for this unexplained heritability, including rare risk variants not adequately tagged thus far in GWAS. That rare susceptibility variants indeed contribute to variation in multifactorial phenotypes has been demonstrated for colorectal cancer, plasma high-density lipoprotein cholesterol levels, blood pressure, type 1 diabetes, hypertriglyceridemia and, in the case of Crohn's disease, for NOD2 (refs. 14,15). Here we describe the use of high-throughput resequencing of DNA pools to search for rare coding variants influencing susceptibility to Crohn's disease in 63 GWAS-identified positional candidate genes. We identify low frequency coding variants conferring protection against inflammatory bowel disease in IL23R, but we conclude that rare coding variants in positional candidates do not make a large contribution to inherited predisposition to Crohn's disease. [less ▲]

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See detailImpact of Greenland and Antarctic ice sheet interactions on climate sensitivity
Goelzer, H.; Huybrechts, P.; Loutre, M.-F. et al

in Climate Dynamics (2011), 37(5-6), 1005-1018

We use the Earth system model of intermediate complexity LOVECLIM to show the effect of coupling interactive ice sheets on the climate sensitivity of the model on a millennial time scale. We compare the ... [more ▼]

We use the Earth system model of intermediate complexity LOVECLIM to show the effect of coupling interactive ice sheets on the climate sensitivity of the model on a millennial time scale. We compare the response to a 2xCO2 warming scenario between fully coupled model versions including interactive Greenland and Antarctic ice sheet models and model versions with fixed ice sheets. For this purpose an ensemble of different parameter sets have been defined for LOVECLIM, covering a wide range of the model's sensitivity to greenhouse warming, while still simulating the present-day climate and the climate evolution over the last millennium within observational uncertainties. Additional freshwater fluxes from the melting ice sheets have a mitigating effect on the model's temperature response, leading to generally lower climate sensitivities of the fully coupled model versions. The mitigation is effectuated by changes in heat exchange within the ocean and at the sea-air interface, driven by freshening of the surface ocean and amplified by sea-ice-related feedbacks. The strength of the effect depends on the response of the ice sheets to the warming and on the model's climate sensitivity itself. With the ensemble approach in this study we cover a wide range of possible model responses. [less ▲]

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See detailBiophysical studies of trigger factors adapted to extreme biological temperatures
Struvay, Caroline; Piette, Florence; Feller, Georges ULg

Poster (2011)

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See detailDeforestation in Central and West Africa: landscape dynamics, anthropogenic effects and ecological consequences.
Barima, Y S S; Djibu, J P; Alongo, S et al

in Daniels, J A (Ed.) Advances in Environmental Research - Volume 7 (2011)

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See detailBRYOPHYTES DU PARC NATIONAL DU MERCANTOUR : METHODES ET RESULTATS DE LA CAMPAGNE D'INVENTAIRES 2010 ATBI+M
Saatkamp, Arne; Aleffi, Michele; de Biaggi, Marta et al

in Biocosme Mesogeen (2011), 28(2), 23-50

During the All Taxa Biodiversity Inventory + Monitoring programme (ATBI+M) in the Mercantour and Alpi Marittime National Parks, our inventories of bryophytes identified 234 taxa (mosses and liverworts ... [more ▼]

During the All Taxa Biodiversity Inventory + Monitoring programme (ATBI+M) in the Mercantour and Alpi Marittime National Parks, our inventories of bryophytes identified 234 taxa (mosses and liverworts). This work completes the previous field campaigns, notably those of Jean-Pierre Hebrard (I MEP, Marseille) since 1965, and the ATBI bryophyte inventories in 2007. This number is based on four days of inventories in the central and peripheric territory of both National Parks, in four days in July and August 2010, together with previous data the 565 taxa known from the area still underestimate the number of species actually present. Our observations in 2010 added several new species for this area, including several rare and remarkable species such as Haplomitrium hookeri or species listed under the Habitats Directive as Buxbaumia viridis and Orthotrichum rogeri. Given the rarity of their habitats species from snow beds, large block boulders and high altitude wetlands are most remarkable. [less ▲]

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See detailTropical forest carbon stocks estimates. Is tree aboveground biomass variability at the landscape scale really non-significant in a REDD+ context?
Bastin, Jean-François ULg; Bogaert, Jan ULg; De Cannière, C

in Research Priorities in Tropical Silviculture: Towards New Paradigms? (2011)

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