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See detailL'articulation des différentes échelles d'observation : le cas d'une recherche sur la coopération roumaine au développement
Teclu, Codrat Alin ULg

Conference (2011)

L'objectif de cette communication est de présenter un aperçu des essais et erreurs que nous avons fait lors de nos deux premières années de thèse afin de concilier le niveau micro-sociologique ... [more ▼]

L'objectif de cette communication est de présenter un aperçu des essais et erreurs que nous avons fait lors de nos deux premières années de thèse afin de concilier le niveau micro-sociologique (interactionniste) avec une échelle plus méso et macro. Après être successivement tombés dans le piège de la démesure empirique puis de la fuite en avant théorique, nous avons finalement réussi à mieux articuler les différents niveaux en choisissant le processus de légitimation comme "centre de gravité" de notre recherche. [less ▲]

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See detailImpact of Greenland and Antarctic ice sheet interactions on climate sensitivity
Goelzer, H.; Huybrechts, P.; Loutre, M.-F. et al

in Climate Dynamics (2011), 37(5-6), 1005-1018

We use the Earth system model of intermediate complexity LOVECLIM to show the effect of coupling interactive ice sheets on the climate sensitivity of the model on a millennial time scale. We compare the ... [more ▼]

We use the Earth system model of intermediate complexity LOVECLIM to show the effect of coupling interactive ice sheets on the climate sensitivity of the model on a millennial time scale. We compare the response to a 2xCO2 warming scenario between fully coupled model versions including interactive Greenland and Antarctic ice sheet models and model versions with fixed ice sheets. For this purpose an ensemble of different parameter sets have been defined for LOVECLIM, covering a wide range of the model's sensitivity to greenhouse warming, while still simulating the present-day climate and the climate evolution over the last millennium within observational uncertainties. Additional freshwater fluxes from the melting ice sheets have a mitigating effect on the model's temperature response, leading to generally lower climate sensitivities of the fully coupled model versions. The mitigation is effectuated by changes in heat exchange within the ocean and at the sea-air interface, driven by freshening of the surface ocean and amplified by sea-ice-related feedbacks. The strength of the effect depends on the response of the ice sheets to the warming and on the model's climate sensitivity itself. With the ensemble approach in this study we cover a wide range of possible model responses. [less ▲]

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See detailLevels of C-reactive protein are associated with response to infliximab therapy in patients with Crohn's disease.
Jurgens, Matthias; Mahachie John, Jestinah ULg; Cleynen, Isabelle et al

in Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of The American Gastroenterological Association (2011), 9(5), 421-71

BACKGROUND & AIMS: Infliximab is an antibody against tumor necrosis factor-alpha that is used to treat patients with moderate to severe Crohn's disease (CD). C-reactive protein (CRP) is a marker used to ... [more ▼]

BACKGROUND & AIMS: Infliximab is an antibody against tumor necrosis factor-alpha that is used to treat patients with moderate to severe Crohn's disease (CD). C-reactive protein (CRP) is a marker used to identify and follow individuals with CD. We analyzed changes in levels of CRP in a large cohort of patients with CD undergoing treatment with infliximab. METHODS: Serial levels of CRP were analyzed in 718 CD patients. Blood was collected before each infusion; a total of 8845 CRP levels were available for analysis. The correlations between CRP levels and need for dose adjustment, outcomes, and mucosal healing (based on endoscopic analysis of 253 patients) were evaluated. Therapy adjustment was considered successful if therapy continued without need for change. Subgroup analysis was performed by using data from 268 patients who received 8 weeks of maintenance therapy. RESULTS: More patients with high baseline levels of CRP responded to infliximab than patients with normal levels (90.8% vs 82.6%; P = .014). Early normalization of CRP levels correlated with sustained long-term response (P < .001). CRP levels remained significantly higher among patients who lost their response to infliximab, compared with those with a sustained response (P = .001). At time of loss of response, CRP levels were significantly increased (median, 11.2 mg/L) and did not return to baseline levels (median, 18.2 mg/L; P = .039). CRP correlated with mucosal healing (P = .033). CONCLUSIONS: CRP is a good marker of disease activity in patients treated with infliximab. Increased levels of CRP indicate mucosal inflammation and a likelihood of clinical relapse. [less ▲]

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See detailMixing in two magnetic OB stars discovered by the MiMeS collaboration
Morel, Thierry ULg

in IAU Symposium 272: Active OB Stars: Structure, Evolution, Mass Loss and Critical Limits (2011)

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See detailLa clause dite de la "mortuaire" plus vivante que jamais
Leleu, Yves-Henri ULg; Geelhand de Merxem, Nicolas

in Journal des Tribunaux (2011), (6423), 93-95

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See detailK-type geomagnetic index nowcast with data quality control
Stankov, Stanimir; Stegen, Koen; Warnant, René ULg

in Annals of Geophysics = Annali di Geofisica (2011), 54(3), 285-295

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See detailOptimal and robust event-related designs for fMRI
Maus, Bärbel ULg; van Breukelen, Gerard J P; Goebel, R et al

Conference (2011)

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See detailClosure to "Energy Dissipation and Turbulent Production in Weak Hydraulic Jumps" by E. Mignot and R. Cienfuegos
Mignot, E.; Peltier, Yann ULg; Cienfuegos, R.

in Journal of Hydraulic Engineering (2011), 137(8), 862-863

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See detailCHOLTIC Epidémies de choléra au lac Tanganyika induites par les changements climatiques ?
Plisnier, Pierre-Denis; Bompangue, Didier; Piarroux, Renaud et al

in Sciences Connection (2011), 35(Juillet-Août), 38-42

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See detailA partial hybrid stress solid-shell element for the analysis of laminated composites
Rah, Kamran; Van Paepegem, Wim; Habraken, Anne ULg et al

in Computer Methods in Applied Mechanics and Engineerinrg (2011), 200(49-52), 35263539

In this paper a low order partial hybrid stress solid-shell element based on the composite energy functional for the analysis of laminated composite structures is presented. This solid-shell element has ... [more ▼]

In this paper a low order partial hybrid stress solid-shell element based on the composite energy functional for the analysis of laminated composite structures is presented. This solid-shell element has eight nodes with only displacement degrees of freedoms, and three-dimensional constitutive models can be directly employed in the present formulation without any additional treatment. The assumed interlaminar stress field provides very accurate interlaminar stress calculation through the element thickness. These elements can be stacked on top of each other to model multilayer structures, fulfilling the interlaminar stress continuity at the interlayer surfaces and zero traction conditions on the top and bottom surfaces of the laminate. The present solid-shell does not show the transverse shear, trapezoidal and thickness locking phenomenon. [less ▲]

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See detailA new Barremian (Early Cretaceous) ichthyosaur from western Russia
Fischer, Valentin ULg; Masure, Edwige; Arkhangelsky, Maxim et al

in Journal of Vertebrate Paleontology (2011), 31(5), 1010-1025

A new ophthalmosaurid ichthyosaur, Sveltonectes insolitus gen. et sp. nov., is described from a sub-complete and three-dimensionally preserved specimen from the late Barremian of western Russia. This new ... [more ▼]

A new ophthalmosaurid ichthyosaur, Sveltonectes insolitus gen. et sp. nov., is described from a sub-complete and three-dimensionally preserved specimen from the late Barremian of western Russia. This new taxon is supported by 11 cranial, dental, and postcranial autapomorphies, and is also characterized by features previously considered as autapomorphic for some other Ophthalmosauridae, such as a processus narialis on the prefrontal and relatively long hindfins with pre- and postaxial accessory digits. We conducted a new phylogenetic analysis of Thunnosauria, which supports a ‘Stenopterygius-origin’ for Ophthalmosauridae. Sveltonectes is regarded as the sister taxon of Aegirosaurus, which shares a similar skull roof construction. Contrary to most other Cretaceous ichthyosaurs, Sveltonectes is characterized by delicate and sharply pointed teeth, confirming that the Ophthalmosauridae were ecologically highly diversified during the Early Cretaceous [less ▲]

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See detailCoping with Minority Status: Responses to Exclusion and Inclusion
Martiniello, Marco ULg

in Contemporary Sociology: a Journal of Reviews (2011), 40(2), 158-159

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See detailNotched Specimens Fracture Prediction with an Advanced GTN Model
Fansi Tchonko, Joseph ULg; Ben Bettaieb, Mohamed ULg; Balan, Tudor et al

in Key Engineering Materials [=KEM] (2011), 488-489

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See detailLa tradizione fiorentina della Supplicatione d’Italia al re di Francia. Con una nuova edizione critica
Moreno, Paola ULg

in Filologia e Critica (2011), XXXV(2), 1-33

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See detailLe Michelsberg de Pont-de-Bonne (province de Liège, Belgique)
Delye, Emmanuel ULg; Gilson, Simon-Pierre; Noiret, Pierre ULg

in Revue Archéologique de Picardie (2011)

Since the beginning of research on the éperon barré of Pont-de-Bonne (Modave, Belgium), we have recovered artefacts attributed to the Middle Neolithic. More recently, during excavation of the entrance ... [more ▼]

Since the beginning of research on the éperon barré of Pont-de-Bonne (Modave, Belgium), we have recovered artefacts attributed to the Middle Neolithic. More recently, during excavation of the entrance system of the fortification, a pot hole and a waste accumulation zone have been analysed. These structures contained abundant archaeological material (ceramic sherd, lithic and bone artefact and fauna). Three radiometric dates have been obtained. The ceramic assemblage is typical of the Belgian Michelsberg and a decorated vase shows Bischheim affinities. [less ▲]

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See detailProceedings of the 1st Scientific Meeting of the Faculty of Veterinary Medicine (Liège – Belgium)
Cabaraux, Jean-François ULg; Delguste, Catherine ULg; Frippiat, Thibault ULg et al

Book published by Presses de la Faculté de Médecine vétérinaire de l’Université de Liège (2011)

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See detailMagnetic susceptibility evolution on Paleozoic sedimentary settings, a clue for past paleoenvironments
Da Silva, Anne-Christine ULg; Pas, Damien ULg; Mabille, Cédric et al

in Suttner; Kido; Piller (Eds.) et al Mid Paleozoic climate and biodiversity. IGCP-596 opening meeting. Abstract Volume (2011)

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See detailProduction et commerce mondial en céréales en 2010/2011
Burny, Philippe ULg

in De Proft, M.; Bodson, B. (Eds.) Livre blanc "Céréales-Gembloux", édition février 2011 (2011)

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See detailNanobodies as structural probes to investigate the mechanism of fibril formation by the amyloidogenic variants of human lysozyme
Dumont, Janice ULg; Pardon, Els; Aumont-Nicaise, Magalie et al

Poster (2011)

Six variants of human lysozyme (single-point mutations I56T, F57I, W64R, D67H and double mutations F57I/T70N, W112R/T70N) are associated with a hereditary non-neuropathic systemic amyloidose. These ... [more ▼]

Six variants of human lysozyme (single-point mutations I56T, F57I, W64R, D67H and double mutations F57I/T70N, W112R/T70N) are associated with a hereditary non-neuropathic systemic amyloidose. These proteins form extracellular amyloid fibrils that deposit in a wide range of tissues and organs such as liver, spleen and kidneys where they cause damages [1]. It was shown that the D67H and I56T mutations cause a loss in stability and more particularly a loss of global cooperativity of protein [1]. Consequently, under physiologically relevant conditions, these variants can transiently populate a partially unfolded state in which the beta-domain and the C-helix are cooperatively unfolded while the rest of the protein remains native like [1]. The formation of intermolecular interactions between the regions that are unfolded in this intermediate state is likely to be a fundamental trigger of the aggregation process that ultimately leads to the formation and deposition of fibrils in tissues. We have also shown that the binding of three variable domain of camelid antibodies or (VHHs) - raised against the wild type human lysozyme inhibit in vitro the formation of amyloid fibrils by the lysozyme variants. These three VHHs bind on different regions of lysozyme and act as amyloid fibrils inhibitor through different mechanisms [2, 3, and unpublished results]. In the present work, sixteen new VHHs specific of human lysozyme have been generated. Competition experiments have shown that they bind to five non overlapping epitopes. We have demonstrated that five of these new VHHs are able to bind lysozyme in conditions used for amyloid fibril formation, and interestingly two of them recognize two epitopes that are different from those of the three VHHs previously characterized [2, 3, and unpublished results]. The effects of these new VHHs on the properties of lysozyme variants such as activity, stability, cooperativity and aggregation will be discussed. [less ▲]

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