References of "2011"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailION MOBILITY – MASS SPECTROMETRY AS A NEW APPROACH FOR THE SCREENING OF PESTICIDE RESIDUES IN FOOD
Goscinny, Séverine ULg; Touilloux, Romain; Joly, Laure et al

in Organohalogen Compounds (2011)

Pesticide residue analysis requires methods that can determine hundreds of compounds at low levels in complex food matrices. This challenge has given rise to multi residue methods, the only efficient ... [more ▼]

Pesticide residue analysis requires methods that can determine hundreds of compounds at low levels in complex food matrices. This challenge has given rise to multi residue methods, the only efficient analytical approach. This type of analytical method entails a “generic” extraction followed by a soft or no purification step to avoid any analytes looses. With over a 1000 active compounds with different physical chemical properties, gas and liquid chromatography are used as complementary separative techniques. In the past decade, the determination has been performed on tandem mass analyzers, a powerful tool to overcome co-eluting compounds with excellent sensitivity. Nevertheless, these instruments can guarantee these results per acquisition cycles for more or less 150 compounds. This represents a serious limitation when the number of pesticides to be sought for monitoring and MRL enforcement is growing each year. As multiple injections from the same sample are not viable for laboratories, alternative options have to be explored. We propose the investigation of ion mobility (IM) coupled with mass spectrometry as a new approach for pesticide residue analysis in food. [less ▲]

Detailed reference viewed: 141 (3 ULg)
Full Text
Peer Reviewed
See detailEffects of haptoglobin polymorphisms and deficiency on susceptibility to inflammatory bowel disease and on severity of murine colitis.
Marquez, L.; Shen, C.; Cleynen, I. et al

in Gut (2011), 61(4), 528-534

BackgroundHaptoglobin (Hp) is a haemoglobin-binding protein with immunomodulatory properties. Its gene (16q22) harbours a common polymorphism with two different alleles: Hp1 and Hp2. Genotype Hp22 has ... [more ▼]

BackgroundHaptoglobin (Hp) is a haemoglobin-binding protein with immunomodulatory properties. Its gene (16q22) harbours a common polymorphism with two different alleles: Hp1 and Hp2. Genotype Hp22 has been shown to be over-represented in different immune diseases. Results in Crohn's disease (CD) are contradictory.AimsTo determine whether Hp plays a role in inflammatory bowel disease, both genetically and functionally.Methods1061 patients with CD, 755 with ulcerative colitis (UC) and 152 with primary sclerosing cholangitis, as well as 452 healthy controls, were genotyped using touch-down PCR. To confirm association results, 464 CD trios and 151 UC trios were genotyped. Serum Hp concentrations were determined in 62 individuals of different genotype. Colitis was induced in mice with dextran sulphate sodium (DSS) and oxazolone (Oxa). Cytokine production was evaluated by mRNA quantification in colonic tissue and ELISA on supernatants of mesenteric lymph node cells.ResultsPrevalence of Hp2 was higher in CD and UC than in controls. In the confirmatory cohorts, Hp2 was over-transmitted to the affected offspring. Serum Hp concentrations were higher in individuals with genotypes Hp11 and Hp21 than in those with Hp22 (1.38 vs 0.89 g/l). DSS- and Oxa-induced colitis were more severe in Hp-deficient mice than in control mice and accompanied by higher concentrations (although not statistically significantly different) of tissue mRNA for cytokines. Interleukin-17 production was significantly higher in the presence of Hp-deficient serum compared with wild-type serum.ConclusionsThe Hp gene may play a role in susceptibility to inflammatory bowel disease. Its implication in other immune diseases underscores the common pathways between these diseases. Experimental models of colitis showed that Hp has a protective role in inflammatory colitis, most likely by inhibiting the production of Th1 and Th17 cytokines. [less ▲]

Detailed reference viewed: 48 (6 ULg)
Full Text
Peer Reviewed
See detailCytochrome P450-mediated cardiovascular drug interactions.
SCHEEN, André ULg

in Expert opinion on drug metabolism & toxicology (2011), 7(9), 1065-82

Introduction: There are numerous drug-drug interactions (DDIs) related to cardiovascular medications and many of these are mediated via the cytochrome P450 (CYP) system. Some of these may lead to serious ... [more ▼]

Introduction: There are numerous drug-drug interactions (DDIs) related to cardiovascular medications and many of these are mediated via the cytochrome P450 (CYP) system. Some of these may lead to serious adverse events and it is, therefore, essential that clinicians are aware of the important interactions that occur. Areas covered: An extensive literature search was performed to analyze the CYP-mediated cardiovascular DDIs that lead to a loss of efficacy or potential toxicity. Cardiovascular drugs may be victims or act as perpetrators of DDIs. The paper analyzes CYP-mediated drug interactions concerning anticoagulants, antiplatelet agents, antiarrhythmics, beta-blockers, calcium antagonists, antihypertensive medications, lipid-lowering drugs and oral antidiabetic agents. Expert opinion: Cardiovascular DDIs involving the CYP system are numerous. Additionally, the spectrum of drugs prescribed is constantly changing, particularly with cardiovascular diseases and it is not necessarily the case that drugs that had shown safety earlier will always show safety. Clinicians are encouraged to develop their knowledge of CYP-mediated DDIs so that they can choose safe drug combination regimens, adjust drug dosages appropriately and conduct therapeutic drug monitoring for drugs with narrow therapeutic indices. [less ▲]

Detailed reference viewed: 108 (6 ULg)
Full Text
Peer Reviewed
See detailSibutramine on cardiovascular outcome.
SCHEEN, André ULg

in Diabetes Care (2011), 34 Suppl 2

Detailed reference viewed: 13 (3 ULg)
Full Text
Peer Reviewed
See detailA graphical method for practical and informative identifiability analyses of physiological models: A case study of insulin kinetics and sensitivity
Docherty, Paul D.; Chase, J Geoffrey; Lotz, Thomas F. et al

in Biomedical Engineering Online (2011), 10

Background: Derivative based a-priori structural identifiability analyses of mathematical models can offer valuable insight into the identifiability of model parameters. However, these analyses are only ... [more ▼]

Background: Derivative based a-priori structural identifiability analyses of mathematical models can offer valuable insight into the identifiability of model parameters. However, these analyses are only capable of a binary confirmation of the mathematical distinction of parameters and a positive outcome can begin to lose relevance when measurement error is introduced. This article presents an integral based method that allows the observation of the identifiability of models with two-parameters in the presence of assay error. Methods: The method measures the distinction of the integral formulations of the parameter coefficients at the proposed sampling times. It can thus predict the susceptibility of the parameters to the effects of measurement error. The method is tested in-silico with Monte Carlo analyses of a number of insulin sensitivity test applications. Results: The method successfully captured the analogous nature of identifiability observed in Monte Carlo analyses of a number of cases including protocol alterations, parameter changes and differences in participant behaviour. However, due to the numerical nature of the analyses, prediction was not perfect in all cases. Conclusions: Thus although the current method has valuable and significant capabilities in terms of study or test protocol design, additional developments would further strengthen the predictive capability of the method. Finally, the method captures the experimental reality that sampling error and timing can negate assumed parameter identifiability and that identifiability is a continuous rather than discrete phenomenon. [less ▲]

Detailed reference viewed: 59 (7 ULg)
Full Text
Peer Reviewed
See detailModel-based optimal PEEP in mechanically ventilated ARDS patients in the Intensive Care Unit
Sundaresan, Ashwath; Chase, J Geoffrey; Shaw, Geoffrey M et al

in Biomedical Engineering Online (2011), 10

Background: The optimal level of positive end-expiratory pressure (PEEP) is still widely debated in treating acute respiratory distress syndrome (ARDS) patients. Current methods of selecting PEEP only ... [more ▼]

Background: The optimal level of positive end-expiratory pressure (PEEP) is still widely debated in treating acute respiratory distress syndrome (ARDS) patients. Current methods of selecting PEEP only provide a range of values and do not provide unique patient-specific solutions. Model-based methods offer a novel way of using non-invasive pressure-volume (PV) measurements to estimate patient recruitability. This paper examines the clinical viability of such models in pilot clinical trials to assist therapy, optimise patient-specific PEEP, assess the disease state and response over time. Methods: Ten patients with acute lung injury or ARDS underwent incremental PEEP recruitment manoeuvres. PV data was measured at increments of 5 cmH(2)O and fitted to the recruitment model. Inspiratory and expiratory breath holds were performed to measure airway resistance and auto-PEEP. Three model-based metrics are used to optimise PEEP based on opening pressures, closing pressures and net recruitment. ARDS status was assessed by model parameters capturing recruitment and compliance. Results: Median model fitting error across all patients for inflation and deflation was 2.8% and 1.02% respectively with all patients experiencing auto-PEEP. In all three metrics' cases, model-based optimal PEEP was higher than clinically selected PEEP. Two patients underwent multiple recruitment manoeuvres over time and model metrics reflected and tracked the state or their ARDS. Conclusions: For ARDS patients, the model-based method presented in this paper provides a unique, non-invasive method to select optimal patient-specific PEEP. In addition, the model has the capability to assess disease state over time using these same models and methods. [less ▲]

Detailed reference viewed: 37 (9 ULg)
Full Text
Peer Reviewed
See detailGas Sensing with Au-Decorated Carbon Nanotubes
Zanolli, Zeila ULg; Leghrib, Radouane; Felten, Alexandre et al

in ACS Nano (2011), 5(6), 4592-4599

The sensing properties of carbon nanotubes (CNTs) decorated with gold nanopar- ticles have been investigated by means of combined theoretical and experimental approaches. On one hand, first-principles and ... [more ▼]

The sensing properties of carbon nanotubes (CNTs) decorated with gold nanopar- ticles have been investigated by means of combined theoretical and experimental approaches. On one hand, first-principles and nonequilibrium Green's functions techniques give access to the microscopic features of the sensing mechanisms in individual nanotubes, such as electronic charge transfers and quantum conductances. On the other hand, drop coating deposition of carbon nanotubes decorated with gold nanoparticles onto sensor substrates and their characterization in the detection of pollutants such as NO2, CO, and C6H6 provide insight into the sensing ability of nanotube mats. Using the present combined approaches, the improvement in the detection of some specific gases (NO2 and CO) using Au-functionalized nanotubes is explained. However, for other gases such as C6H6, the Au nanoparticles do not seem to play a crucial role in the sensing process when compared with pristine CNTs functionalized with oxygen plasma. Indeed, these different situations can be explained by identifying the relationship between the change of resistance (macroscopic feature) and the shift of the Fermi level (microscopic feature) after gas adsorption. The understanding of the sensing ability at the atomic level opens the way to design new gas sensors and to tune their selectivity by predicting the nature of the metal that is the most appropriate to detect specific molecular species. [less ▲]

Detailed reference viewed: 47 (6 ULg)
Full Text
Peer Reviewed
See detailIntensity dependence of auditory evoked potentials during light interference in migraine.
Ambrosini, Anna; Coppola, Gianluca; Gerardy, Pierre-Yves et al

in Neuroscience letters (2011), 492(2), 80-3

Migraine patients show interictally a strong intensity dependence of auditory evoked cortical potentials (IDAP) and a lack of habituation of evoked potentials. Photic drive on high-frequency flash ... [more ▼]

Migraine patients show interictally a strong intensity dependence of auditory evoked cortical potentials (IDAP) and a lack of habituation of evoked potentials. Photic drive on high-frequency flash stimulation is another well-known interictal feature in migraineurs, associated with alpha-rhythm hyper-synchronisation. We compared therefore the influence of light stimulation on IDAP in healthy volunteers (HV) and migraine patients. A continuous flash stimulation was delivered during the recording of auditory evoked potentials at suprathreshold increasing stimulation intensities. IDAP was measured as the amplitude/stimulus intensity function (ASF) slope. In HV, the ASF slope decreased during flash stimulation, whereas, on average, there was no significant change in migraineurs. A closer analysis of migraineurs disclosed two subgroups of patients with no detectable clinical differences: one, the largest, in which the ASF slope was normal at baseline, but increased during light stimulation, the other with an increased ASF slope at rest and a decrease during light interference. Visual sensory overload is able to increase IDAP in the majority of migraineurs, which contrasts with HV. We hypothesise that this could be due to hyper-synchronisation of the alpha rhythm because of photic drive and possibly thalamo-cortical dysfunction. A minority of migraineurs have, like HV, an IDAP reduction during light interference. They are, however, characterised, unlike most HV, by a high IDAP at baseline. Besides underscoring the pathophysiological heterogeneity of migraine, these results suggest that light interference might improve the phenotyping of migraine patients who have a normal IDAP in the resting condition. [less ▲]

Detailed reference viewed: 24 (4 ULg)
Full Text
Peer Reviewed
See detailIs chronic migraine a never-ending migraine attack?
Schoenen, Jean ULg

in Pain (2011), 152(2), 239-40

Detailed reference viewed: 71 (4 ULg)
Full Text
See detailHet buikgevoel van Congolese schilders
Geenen, Kristien ULg

in Kin moto na Anvers (2011)

Detailed reference viewed: 17 (0 ULg)
Full Text
See detailImpact of germline AIP mutations on tumor characteristics and Management in young acromegalic patients : results of an age-and tumor diameter matched cohort study
Tichomirowa, Maria A.; Theodoropoulou, Marily; Daly, Adrian ULg et al

in Abstract book - Endo 2011 (2011)

Detailed reference viewed: 19 (5 ULg)
Full Text
Peer Reviewed
See detailLa parentalité dans un couple lesbien: enjeux et questionnements
Naziri, Despina ULg; Dargentas, Magda

in Cahiers de Psychologie Clinique (2011), 37(2), 203-229

In the framework of a clinical study on the psychic processes affecting partners in lesbian couples, who seek access to parenthood, this article analyzes the testimony of female couples preparing for ... [more ▼]

In the framework of a clinical study on the psychic processes affecting partners in lesbian couples, who seek access to parenthood, this article analyzes the testimony of female couples preparing for Artificial Insemination with Donor (AID) and takes account of their personal and family history, as well as the dynamics of the couple itself. The methodology used and the data found are presented. The approach combines a longitudinal and psychodynamic study (illustrated with selected case studies) and a textual analysis (with the ALCESTE software) of clinical interviews of both partners of 32 lesbian couples, who sought to become parents through the use of AID. The combination of results from both analyses leads to a discussion of three factors affecting access to homoparenthood and the construction of a parental project for lesbian couples: i.e., the place given to the anonymous donor, the impact of the medical act of AID and the process of assigning the status of social mother and biological mother within the lesbian couple. [less ▲]

Detailed reference viewed: 109 (17 ULg)
Full Text
Peer Reviewed
See detailAmphibia-Reptilia - Editorial report 2010
Denoël, Mathieu ULg; Ursenbacher, sylvain; Harris, D. James

in Amphibia-Reptilia (2011), 32(4), 575-576

Detailed reference viewed: 52 (4 ULg)
Full Text
Peer Reviewed
See detailAntiplasmodial, anti-inflammatory and cytotoxic activities of various plant extracts from the Mascarene Archipelago.
Jonville, Marie ULg; Kodja, H.; Strasberg, D. et al

in Journal of Ethnopharmacology (2011), 136

AIM OF THE STUDY: Antiplasmodial activity, inhibition of nitric oxide (NO) overproduction, and anti-proliferative activity were investigated in vitro to evaluate the bioactive potential of the traditional ... [more ▼]

AIM OF THE STUDY: Antiplasmodial activity, inhibition of nitric oxide (NO) overproduction, and anti-proliferative activity were investigated in vitro to evaluate the bioactive potential of the traditional pharmacopoeia of the Mascarene Archipelago, which is known for its biodiversity and for the richness of its endemic flora. MATERIALS AND METHODS: A total of 45 methanol (MeOH) and dichloromethane (DCM) extracts were prepared from 19 plant species collected on Reunion and Mauritius Islands. Ninety-six-well microplate assays were performed on chloroquine sensitive Plasmodium falciparum 3D7 strain, on LPS-stimulated Raw 264.7 murine macrophages and on A-549, DLD-1 and WS1 human cells. Activity was evaluated through spectrophotometric methods. RESULTS: Activity was attributed to plant extracts expressing IC(50)<50mug/ml for antiplasmodial response, IC(50)<100mug/ml for cytotoxicity, and IC(50)<130mug/ml for anti-inflammatory reaction. The majority of the extracts tested (69%) exhibited potency in at least one of these three types of activity. This is the first report describing promising antiplasmodial activity (IC(50)<15mug/ml) for Psiadia dentata DCM extract and Terminalia bentzoe MeOH bark extract. NO inhibition assay revealed seven interesting plants, described for the first time as anti-inflammatory: Aphloia theiformis, Buddleja salviifolia, Eupatorium riparium, Hiptage benghalensis, Psiadia arguta, Psiadia dentata, and Scutia commersonii. Finally, anti-proliferative activity was observed for two endemic species, Geniostoma borbonicum and Nuxia verticillata. CONCLUSION: Using the criterion of endemism as part of the criteria for traditional medicinal use raises the chances of finding original active principles. In our case, 86% of the endemic plants tested displayed pharmacological interest. [less ▲]

Detailed reference viewed: 190 (31 ULg)
See detailConférences: les rencontres du CEA en 2010
Van Ruymbeke, Muriel ULg

Report (2011)

Detailed reference viewed: 23 (5 ULg)
Full Text
See detailL’adaptation au changement climatique en région wallonne : Fiche thématique : Biodiversité
Frisson, Gwenn ULg; Monty, Arnaud ULg; Mahy, Grégory ULg et al

Report (2011)

• Les changements attendus sont importants mais difficiles à quantifier. Seules des tendances peuvent être dégagées. • La fragmentation des habitats naturels est particulièrement poussée en Wallonie. Elle ... [more ▼]

• Les changements attendus sont importants mais difficiles à quantifier. Seules des tendances peuvent être dégagées. • La fragmentation des habitats naturels est particulièrement poussée en Wallonie. Elle constitue une lourde menace sur la biodiversité et une entrave aux changements d’aires de distribution attendus. • Développer le réseau écologique et diminuer les menaces qui pèsent actuellement sur la biodiversité est primordial pour donner une chance à la biodiversité de s’adapter au changement climatique. • Les impacts de la perte de biodiversité ne doivent pas seulement se mesurer en termes de valeur intrinsèque mais également en termes de services écosystémiques. [less ▲]

Detailed reference viewed: 50 (14 ULg)
Full Text
Peer Reviewed
See detailFinite Element Computational Homogenization of Nonlinear Multiscale Materials in Magnetostatics
Niyonzima, Innocent ULg; V Sabariego, Ruth ULg; Dular, Patrick ULg et al

in 18th Conference on the Computation of Electromagnetic Fields (COMPUMAG2011) (2011)

This paper deals with the modelling of nonlinear multiscale materials in magnetostatics by means of a finite element computational homogenization method. The method couples a macroscale problem with many ... [more ▼]

This paper deals with the modelling of nonlinear multiscale materials in magnetostatics by means of a finite element computational homogenization method. The method couples a macroscale problem with many microscale problems. During the upscaling step, the homogenized magnetic permeability and its derivative with respect to the magnetic field are calculated from the microscale solution and transferred to the macroscale. The downscaling step consists in imposing proper boundary conditions for the microscale problems from the macroscale solution. Results are validated by comparison with those obtained with classical finite element brute force approach. [less ▲]

Detailed reference viewed: 94 (18 ULg)
Full Text
Peer Reviewed
See detailAnalyse des potentialités d'accueil du lynx boréal (Lynx lynx) dans l'est de la province de Liège (Belgique)
Thiry, Violaine; Schockert, Vincianne ULg; Libois, Roland ULg et al

in Rosoux, René; de Bellefroid, Marie des Neiges; Baillon, Jacques (Eds.) et al Lynx... le grand retour ? (2011)

The fist lynx were seen in eastern Belgium at the end of the 1990s. Since then, both sightings and tracks have been recorded there and in the Ardenne (south east Belgium). Whether this presence indicates ... [more ▼]

The fist lynx were seen in eastern Belgium at the end of the 1990s. Since then, both sightings and tracks have been recorded there and in the Ardenne (south east Belgium). Whether this presence indicates a spontaneous return of individuals deriving from the population reintroduced in Germany or results from illicit releases, it raises the question of the suitability and the carrying capacity of habitats in an area of dense human occupation. Using two software programs, a mapping model to assess habitat characterization, drawn from relevant criteria for this species, was tested to estimate the potential host of the study area, via the determination of areas of suitable habitats, and the dispersion potential of the species, through the identification of the most viable dispersal corridors. The findings of the study (multi criteria analysis of potential host of habitats, identification of corridors of lowest cost, estimation of the potential population...), compiled on the basis mapping model and simulations, suggest that a return of the lynx in Wallonia may be sustainable if supported and managed wisly by the regional administrative services. [less ▲]

Detailed reference viewed: 213 (20 ULg)
Full Text
Peer Reviewed
See detailCan light make us bright? Effects of light on cognition and sleep.
Chellappa, Sarah Laxhmi ULg; Gordijn, Marijke C. M.; Cajochen, Christian

in Progress in Brain Research (2011), 190

Light elicits robust nonvisual effects on numerous physiological and behavioral variables, such as the human sleep-wake cycle and cognitive performance. Light effects crucially rely on properties such as ... [more ▼]

Light elicits robust nonvisual effects on numerous physiological and behavioral variables, such as the human sleep-wake cycle and cognitive performance. Light effects crucially rely on properties such as dose, duration, timing, and wavelength. Recently, the use of methods such as fMRI to assess light effects on nonvisual brain responses has revealed how light can optimize brain function during specific cognitive tasks, especially in tasks of sustained attention. In this chapter, we address two main issues: how light impinges on cognition via consolidation of human sleep-wake cycles; and how light directly impacts on sleep and cognition, in particular in tasks of sustained attention. A thorough understanding of how light affects sleep and cognitive performance may help to improve light settings at home and at the workplace in order to improve well-being. [less ▲]

Detailed reference viewed: 334 (1 ULg)