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See detailNanobodies as structural probes to investigate the mechanism of fibril formation by the amyloidogenic variants of human lysozyme
Dumont, Janice ULg; Pardon, Els; Aumont-Nicaise, Magalie et al

Poster (2011)

Six variants of human lysozyme (single-point mutations I56T, F57I, W64R, D67H and double mutations F57I/T70N, W112R/T70N) are associated with a hereditary non-neuropathic systemic amyloidose. These ... [more ▼]

Six variants of human lysozyme (single-point mutations I56T, F57I, W64R, D67H and double mutations F57I/T70N, W112R/T70N) are associated with a hereditary non-neuropathic systemic amyloidose. These proteins form extracellular amyloid fibrils that deposit in a wide range of tissues and organs such as liver, spleen and kidneys where they cause damages [1]. It was shown that the D67H and I56T mutations cause a loss in stability and more particularly a loss of global cooperativity of protein [1]. Consequently, under physiologically relevant conditions, these variants can transiently populate a partially unfolded state in which the beta-domain and the C-helix are cooperatively unfolded while the rest of the protein remains native like [1]. The formation of intermolecular interactions between the regions that are unfolded in this intermediate state is likely to be a fundamental trigger of the aggregation process that ultimately leads to the formation and deposition of fibrils in tissues. We have also shown that the binding of three variable domain of camelid antibodies or (VHHs) - raised against the wild type human lysozyme inhibit in vitro the formation of amyloid fibrils by the lysozyme variants. These three VHHs bind on different regions of lysozyme and act as amyloid fibrils inhibitor through different mechanisms [2, 3, and unpublished results]. In the present work, sixteen new VHHs specific of human lysozyme have been generated. Competition experiments have shown that they bind to five non overlapping epitopes. We have demonstrated that five of these new VHHs are able to bind lysozyme in conditions used for amyloid fibril formation, and interestingly two of them recognize two epitopes that are different from those of the three VHHs previously characterized [2, 3, and unpublished results]. The effects of these new VHHs on the properties of lysozyme variants such as activity, stability, cooperativity and aggregation will be discussed. [less ▲]

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See detailTax Evasion, Welfare Fraud, and "The Broken Windows" Effect: An Experiment in Belgium, France and the Netherlands
Lefebvre, Mathieu ULg; Pestieau, Pierre ULg; Riedl, Arno et al

E-print/Working paper (2011)

In a series of experiments conducted in Belgium (Wallonia and Flanders), France and the Netherlands, we compare behavior regarding tax evasion and welfare dodging, with and without information about ... [more ▼]

In a series of experiments conducted in Belgium (Wallonia and Flanders), France and the Netherlands, we compare behavior regarding tax evasion and welfare dodging, with and without information about others’ behavior. Subjects have to decide between a ‘registered’ income, the realization of which will be known to the tax authority for sure, and an ‘unregistered’ income that will only be known with some probability. This unregistered income comes from self-employment in the Tax treatment and from black labor supplementing some unemployment compensation in the Welfare treatment. Subjects have then to decide on whether reporting their income or not, knowing the risk of detection. The results show that (i) individuals evade more in the Welfare treatment than in the Tax treatment; (ii) many subjects choose an option that allows for tax evasion or welfare fraud but report their income honestly anyway; (iii) examples of low compliance tend to increase tax evasion while examples of high compliance exert no influence; (iv) tax evasion is more frequent in France and the Netherlands; Walloons evade taxes less than the Flemish. There is no cross-country difference in welfare dodging. [less ▲]

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See detailTraumatologie du basketball
Kaux, Jean-François ULg; Crielaard, Jean-Michel ULg

Learning material (2011)

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See detailSequencing of DISC1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern Swedish population.
Moens, Lotte N.; De Rijk, Peter; Reumers, Joke et al

in PloS one (2011), 6(8), 23450

In recent years, DISC1 has emerged as one of the most credible and best supported candidate genes for schizophrenia and related neuropsychiatric disorders. Furthermore, increasing evidence--both genetic ... [more ▼]

In recent years, DISC1 has emerged as one of the most credible and best supported candidate genes for schizophrenia and related neuropsychiatric disorders. Furthermore, increasing evidence--both genetic and functional--indicates that many of its protein interaction partners are also involved in the development of these diseases. In this study, we applied a pooled sample 454 sequencing strategy, to explore the contribution of genetic variation in DISC1 and 10 of its interaction partners (ATF5, Grb2, FEZ1, LIS-1, PDE4B, NDE1, NDEL1, TRAF3IP1, YWHAE, and ZNF365) to schizophrenia susceptibility in an isolated northern Swedish population. Mutation burden analysis of the identified variants in a population of 486 SZ patients and 514 control individuals, revealed that non-synonymous rare variants with a MAF<0.01 were significantly more present in patients compared to controls (8.64% versus 4.7%, P = 0.018), providing further evidence for the involvement of DISC1 and some of its interaction partners in psychiatric disorders. This increased burden of rare missense variants was even more striking in a subgroup of early onset patients (12.9% versus 4.7%, P = 0.0004), highlighting the importance of studying subgroups of patients and identifying endophenotypes. Upon investigation of the potential functional effects associated with the identified missense variants, we found that approximately 90% of these variants reside in intrinsically disordered protein regions. The observed increase in mutation burden in patients provides further support for the role of the DISC1 pathway in schizophrenia. Furthermore, this study presents the first evidence supporting the involvement of mutations within intrinsically disordered protein regions in the pathogenesis of psychiatric disorders. As many important biological functions depend directly on the disordered state, alteration of this disorder in key pathways may represent an intriguing new disease mechanism for schizophrenia and related neuropsychiatric diseases. Further research into this unexplored domain will be required to elucidate the role of the identified variants in schizophrenia etiology. [less ▲]

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See detailContinuous-flow production of alkyl nitrites
Monbaliu, Jean-Christophe ULg; Jorda, Jeremy; Chevalier, Bérengère et al

in Chimica Oggi = Chemistry Today (2011), 29

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See detailLattice dynamics in the FeSb3 skutterudite
Moechel, A.; Sergueev, I.; Long, Gary J. et al

in Physical Review (2011), 84(6),

Thin films of FeSb3 were characterized by electronic transport magnetometry, x-ray diffraction, Fe-57 and Sb-121 nuclear inelastic scattering, and Fe-57 Mossbauer spectroscopy. Resistivity and ... [more ▼]

Thin films of FeSb3 were characterized by electronic transport magnetometry, x-ray diffraction, Fe-57 and Sb-121 nuclear inelastic scattering, and Fe-57 Mossbauer spectroscopy. Resistivity and magnetometry measurements reveal semiconducting behavior with a 16.3(4) meV band gap and an effective paramagnetic moment of 0.57(6) mu(B) respectively. A systematic comparison of the lattice dynamics with CoSb3 and EuFe4Sb12 reveals that the Fe4Sb12 framework is softer than the Co4Sb12 framework, and that the observed softening and the associated lowering of the lattice thermal conductivity in the RFe4Sb12 filled skutterudites are not only related to the filler but also to the Fe4Sb12 framework. [less ▲]

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See detailImpact of Greenland and Antarctic ice sheet interactions on climate sensitivity
Goelzer, H.; Huybrechts, P.; Loutre, M.-F. et al

in Climate Dynamics (2011), 37(5-6), 1005-1018

We use the Earth system model of intermediate complexity LOVECLIM to show the effect of coupling interactive ice sheets on the climate sensitivity of the model on a millennial time scale. We compare the ... [more ▼]

We use the Earth system model of intermediate complexity LOVECLIM to show the effect of coupling interactive ice sheets on the climate sensitivity of the model on a millennial time scale. We compare the response to a 2xCO2 warming scenario between fully coupled model versions including interactive Greenland and Antarctic ice sheet models and model versions with fixed ice sheets. For this purpose an ensemble of different parameter sets have been defined for LOVECLIM, covering a wide range of the model's sensitivity to greenhouse warming, while still simulating the present-day climate and the climate evolution over the last millennium within observational uncertainties. Additional freshwater fluxes from the melting ice sheets have a mitigating effect on the model's temperature response, leading to generally lower climate sensitivities of the fully coupled model versions. The mitigation is effectuated by changes in heat exchange within the ocean and at the sea-air interface, driven by freshening of the surface ocean and amplified by sea-ice-related feedbacks. The strength of the effect depends on the response of the ice sheets to the warming and on the model's climate sensitivity itself. With the ensemble approach in this study we cover a wide range of possible model responses. [less ▲]

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See detailPerception and understanding of invasive alien species issues by nature conservation and horticulture professionals in Belgium
Vanderhoeven, Sonia; Piqueray, Julien ULg; Halford, Mathieu ULg et al

in Environmental Management (2011), 47

We conducted a survey to determine how two professional sectors in Belgium, horticulture professionals and nature reserve managers (those directly involved in conservation), view the issues associated ... [more ▼]

We conducted a survey to determine how two professional sectors in Belgium, horticulture professionals and nature reserve managers (those directly involved in conservation), view the issues associated with invasive plant species. We developed and utilized a questionnaire that addressed the themes of awareness, concept and use of language, availability of information, impacts and, finally, control and available solutions. Using co-inertia analyses, we tested to what extent the perception of invasive alien species (IAS) was dependent upon the perception of Nature in general. Only forty-two percent of respondent horticulture professionals and eighty-two percent of nature reserve managers had a general knowledge of IAS. Many individuals in both target groups nonetheless had an accurate understanding of the scientific issues. Our results therefore suggest that the manner in which individuals within the two groups view, or perceive, the IAS issue was more the result of lack of information than simply biased perceptions of target groups. Though IAS perceptions by the two groups diverged, they were on par with how they viewed Nature in general. The descriptions of IAS by participants converged with the ideas and concepts frequently found in the scientific literature. Both managers and horticulture professionals expressed a strong willingness to participate in programs designed to prevent the spread of, and damage caused by, IAS. Despite this, the continued commercial availability of many invasive species highlighted the necessity to use both mandatory and voluntary approaches to reduce their re-introduction and spread. The results of this study provide stakeholders and conservation managers with practical information on which communication and management strategies can be based. [less ▲]

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See detailEffect of the activating agent on physico-chemical and electrical properties of activated carbon cloths developed from a novel cellulosic precursor
Ramos, ME; Bonelli, PR; Blacher, Silvia ULg et al

in Colloids and Surfaces A : Physicochemical and Engineering Aspects (2011), 378(1-3), 87-93

Different chemical reagents (phosphoric acid, boric acid, ammonium citrate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, disodium hydrogen phosphate and trisodium phosphate) were employed ... [more ▼]

Different chemical reagents (phosphoric acid, boric acid, ammonium citrate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, disodium hydrogen phosphate and trisodium phosphate) were employed to develop activated carbon cloths (ACC) by chemical activation of a lyocell precursor, in an attempt to explore their effect on main physico-chemical characteristics and electrical behaviour of the resulting ACC. The activating agent markedly influenced yield, elemental composition, and textural properties of the ACC. The ACC obtained with phosphoric and boric acids were essentially microporous, whereas those developed with the other reagents presented mesoporosity development. Phosphoric acid-derived samples showed the highest specific surface area (976 m2/g). The results also highlight the relevance of correcting the external surface adsorption in order to obtain reliable estimates of micropore volume. All the ACC were electrically conductive, their resistivity being also strongly dependent on the nature of the activating agent. The electrical resistivity of the ACC obtained with all the phosphorous compounds was successfully correlated with their C/H ratio and micropore volume [less ▲]

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See detailProduction et commerce mondial en céréales en 2010/2011
Burny, Philippe ULg

in De Proft, M.; Bodson, B. (Eds.) Livre blanc "Céréales-Gembloux", édition février 2011 (2011)

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See detailL’allo-immunisation fœto-maternelle ABO peut être sévère
SENTERRE, Thibault ULg; Mignon, J.-M.; Rigo, Jacques ULg

in Archives de Pédiatrie (2011), 18

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See detailL'articulation des différentes échelles d'observation : le cas d'une recherche sur la coopération roumaine au développement
Teclu, Codrat Alin ULg

Conference (2011)

L'objectif de cette communication est de présenter un aperçu des essais et erreurs que nous avons fait lors de nos deux premières années de thèse afin de concilier le niveau micro-sociologique ... [more ▼]

L'objectif de cette communication est de présenter un aperçu des essais et erreurs que nous avons fait lors de nos deux premières années de thèse afin de concilier le niveau micro-sociologique (interactionniste) avec une échelle plus méso et macro. Après être successivement tombés dans le piège de la démesure empirique puis de la fuite en avant théorique, nous avons finalement réussi à mieux articuler les différents niveaux en choisissant le processus de légitimation comme "centre de gravité" de notre recherche. [less ▲]

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See detailARM XIX-la séquence SI.LA2 2 = si-la2-min (NP) et quelques relectures de noms propres
Colonna d'Istria, Laurent ULg

in Nouvelles Assyriologiques Brèves et Utilitaires (2011)

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See detailAnalyses biophysiques des interactions peptide-monocouches à l’interface air-eau
Nasir, Mehmet Nail ULg; Benichou, Emmanuel; Brevet, Pierre-François et al

Poster (2011)

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See detailÉnergie nécessaire au broyage de la biomasse et des produits densifiés
Temmerman, Michaël ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2011)

La littérature concernant la consommation énergétique du broyage dans les industries minières montre que cette problématique a été, et est encore, étudiée par de nombreux auteurs. Différents modèles de ... [more ▼]

La littérature concernant la consommation énergétique du broyage dans les industries minières montre que cette problématique a été, et est encore, étudiée par de nombreux auteurs. Différents modèles de broyage sont donc disponibles pour ces industries, en particulier pour le broyage des minerais. Les principaux modèles et certaines de leurs évolutions sont repris dans la présente revue. Le broyage de la biomasse quant à lui a été bien moins étudié. Quelques études ont néanmoins porté sur la mesure des consommations énergétiques engendrées par le broyage de biomasses particulières, dans des systèmes particuliers. Rares sont celles qui prennent en compte suffisamment de paramètres relatifs à la matière entrante et sortante (granulométrie, humidité, origine, etc.) ou les caractéristiques du système de broyage. Pratiquement, aucun modèle de broyage de la biomasse n’a donc été proposé. Concernant le broyage des produits densifiés, aucune donnée ne semble disponible. À la lueur des théories de broyage de l’industrie minière, cette étude propose donc les paramètres à prendre en compte pour une éventuelle modélisation du broyage de la biomasse et des produits densifiés. Mots-clés. Broyage, biomasse, pellets, briquettes, théories [less ▲]

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See detailK-type geomagnetic index nowcast with data quality control
Stankov, Stanimir; Stegen, Koen; Warnant, René ULg

in Annals of Geophysics = Annali di Geofisica (2011), 54(3), 285-295

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See detailX-ray CT study of the influence of liquid viscosity on fluid phase distribution in modular catalytic packings
Aferka, Saïd ULg; Viva, Aurora; Brunazzi, Elisabetta et al

in Chemical Engineering Transactions (2011), 24

In the frame of the present study, the influence of liquid viscosity on liquid holdup distribution in a packed column equipped with the modular catalytic packing Katapak-SP 11 is measured. Water and an ... [more ▼]

In the frame of the present study, the influence of liquid viscosity on liquid holdup distribution in a packed column equipped with the modular catalytic packing Katapak-SP 11 is measured. Water and an aqueous solution of glycerine, the viscosity of which equals 10 cP, are used as feed liquids. The estimation of liquid holdup is of great interest due to its strong influence on pressure drop, on solid wetting and on heat and mass transfer coefficients. The experimental technique used is high energy X-ray tomography, which is a unique technique to visualize the local liquid distribution inside the complex structure of packings and to quantify the liquid holdup at different scales. [less ▲]

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See detailLa clause dite de la "mortuaire" plus vivante que jamais
Leleu, Yves-Henri ULg; Geelhand de Merxem, Nicolas

in Journal des Tribunaux (2011), (6423), 93-95

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