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See detailMathematical modeling of cell-cell and cell-matrix adhesion in tissue engineering using continuum models
Geris, Liesbet ULg; Gerisch, A.

in Geffen, A. (Ed.) Cellular and Biomolecular Mechanics and Mechanobiology (2011)

Key factors in the formation of cell aggregates in tissue engineering and other fields are the cell-cell and cell-matrix interactions. Other important factors are culture conditions such as nutrient and ... [more ▼]

Key factors in the formation of cell aggregates in tissue engineering and other fields are the cell-cell and cell-matrix interactions. Other important factors are culture conditions such as nutrient and oxygen supply and the characteristics of the environment (medium versus hydrogel). As mathematical models are increasingly used to investigate biological phenomena, it is important that processes such as cell adhesion are adequately described in the models. Recently a technique was developed to incorporate cell-cell and cell-matrix adhesion in continuum models through the use of non-local terms. In this study we apply this technique to model adhesion in a cell-in-gel culture set-up often found in tissue engineering applications. We briefly describe the biological issues underlying this study and the various modeling techniques used to capture adhesive behaviour. We furthermore elaborate on the numerical techniques that were developed in the course of this study. Finally, we consider a tissue engineering model that describes the spatiotemporal evolution of the concentration of cells, matrix, hydrogel, matrix degrading enzymes and oxygen/nutrients in a cell-in-gel culture system. Sensitivity analyses indicate a clear influence of the different adhesive processes on the final cell and collagen density and distribution, demonstrating the significance of cell adhesion in tissue engineering and the potential of the proposed mathematical technique. [less ▲]

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See detailInvolvement of z-MMP-2 in Zebrafish lymphangiogenesis
Paupert, Jenny ULg; Pendeville, Hélène; Detry, Benoît ULg et al

Conference (2011)

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See detailpi N transition distribution amplitudes: Their symmetries and constraints from chiral dynamics
Pire, Bernard; Semenov-Tyan-Shanskiy, Kirill ULg; Szymanowski, Lech

in Physical Review. D : Particles and Fields (2011), 84

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See detailSubject-specific cardiovascular system model-based identification and diagnosis of septic shock with a minimally invasive data set: animal experiments and proof of concept.
Chase, J Geoffrey; Lambermont, Bernard ULg; Starfinger, Christina et al

in Physiological Measurement (2011), 32(1), 65-82

A cardiovascular system (CVS) model and parameter identification method have previously been validated for identifying different cardiac and circulatory dysfunctions in simulation and using porcine models ... [more ▼]

A cardiovascular system (CVS) model and parameter identification method have previously been validated for identifying different cardiac and circulatory dysfunctions in simulation and using porcine models of pulmonary embolism, hypovolemia with PEEP titrations and induced endotoxic shock. However, these studies required both left and right heart catheters to collect the data required for subject-specific monitoring and diagnosis-a maximally invasive data set in a critical care setting although it does occur in practice. Hence, use of this model-based diagnostic would require significant additional invasive sensors for some subjects, which is unacceptable in some, if not all, cases. The main goal of this study is to prove the concept of using only measurements from one side of the heart (right) in a 'minimal' data set to identify an effective patient-specific model that can capture key clinical trends in endotoxic shock. This research extends existing methods to a reduced and minimal data set requiring only a single catheter and reducing the risk of infection and other complications-a very common, typical situation in critical care patients, particularly after cardiac surgery. The extended methods and assumptions that found it are developed and presented in a case study for the patient-specific parameter identification of pig-specific parameters in an animal model of induced endotoxic shock. This case study is used to define the impact of this minimal data set on the quality and accuracy of the model application for monitoring, detecting and diagnosing septic shock. Six anesthetized healthy pigs weighing 20-30 kg received a 0.5 mg kg(-1) endotoxin infusion over a period of 30 min from T0 to T30. For this research, only right heart measurements were obtained. Errors for the identified model are within 8% when the model is identified from data, re-simulated and then compared to the experimentally measured data, including measurements not used in the identification process for validation. Importantly, all identified parameter trends match physiologically and clinically and experimentally expected changes, indicating that no diagnostic power is lost. This work represents a further with human subjects validation for this model-based approach to cardiovascular diagnosis and therapy guidance in monitoring endotoxic disease states. The results and methods obtained can be readily extended from this case study to the other animal model results presented previously. Overall, these results provide further support for prospective, proof of concept clinical testing with humans. [less ▲]

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See detailLes festivals et la transformation du champ théâtral en Belgique
Delhalle, Nancy ULg

Conference (2011)

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See detailKurt Smith, Matter Matters. Metaphysics and Methodology in the Early Modern Period
Dubouclez, Olivier ULg

in Bulletin cartésien (2011)

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See detailGobernabilidad desde las agrupaciones usuarias del agua con fines agrícolas en 8 municipios del territorio de la Mancomunidad de Municipios de la cuenca del río Naranjo (MANCUERNA)
Estrada Orozco, Nick Kenner ULg; Mux, Victor

in Tikalia (2011), XXIX(1-2), 37-46

En Guatemala, para alcanzar los Objetivos de desarrollo del Milenio se implemen- tan Programas Conjuntos con el apoyo del Sistema de Naciones Unidas. Existen en la actualidad cinco Programas Conjuntos ... [more ▼]

En Guatemala, para alcanzar los Objetivos de desarrollo del Milenio se implemen- tan Programas Conjuntos con el apoyo del Sistema de Naciones Unidas. Existen en la actualidad cinco Programas Conjuntos apoyando temas de seguridad alimen- taria, construcción de la paz, cambio climático, género y gobernabilidad económi- ca del agua. En el marco del programa conjunto: “Gobernabilidad económica en agua y sanea- miento” se decidió realizar un estudio que permitiera conocer la gobernabilidad en el sector a partir de hacer un inventario de las agrupaciones usuarias de agua con fines agrícolas y conocer algunas de sus características, este estudio contó con la asesoría técnica de la Organización de las Naciones Unidas para la Agricultura y la Alimentación –FAO– y el apoyo en campo de las comunidades asociadas por el agua y el medio ambiente de la cuenca del río Naranjo –CADISNA– en coordina- ción con el Ministerio de Agricultura Ganadería y Alimentación –MAGA– y go- biernos locales. El estudio se realizó en 8 municipios, 3 del departamento de Quetzaltenango y 5 de San Marcos, se identificaron 126 grupos de riego, de ellos, 73 pudieron ser carac- terizados. Se conoció que el 92% de los 73 grupos tiene una junta directiva que vela por el funcionamiento del sistema y la producción se ve diversificada en al menos 14 diferentes hortalizas siendo la principal el cultivo de la Papa. Sin embar- go sólo el 45% paga una tarifa a su grupo y el 60% de los usuarios necesita crédito para poder producir, haciendo uso de al menos 271.99 Lts/seg de agua para fines agrícolas. [less ▲]

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See detailIntérêts et limites du bilan neuropsychologique dans le cadre de l’expertise médicolégale
Meulemans, Thierry ULg

in Douleur et Analgésie (2011), 24(1), 41-55

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See detailMultiparametric observation and analysis of the Sea
Alvera Azcarate, Aïda ULg; Poulain, Pierre-Marie

in Ocean Dynamics (2011)

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See detailRaconter le paysage de la recherche
Mougenot, Catherine ULg

Book published by QUAE (2011)

C’est à un voyage à l’intérieur de la recherche que nous convie Catherine Mougenot, hors des sentiers battus des évaluations, des acquis et des résultats chiffrés. L’aventure commence à l’occasion du ... [more ▼]

C’est à un voyage à l’intérieur de la recherche que nous convie Catherine Mougenot, hors des sentiers battus des évaluations, des acquis et des résultats chiffrés. L’aventure commence à l’occasion du programme de recherche «Action publique, agriculture et biodiversité» rassemblant une communauté très large de chercheurs de terrain : écologues, agronomes, sociologues, géographes, économistes, politiciens, anthropologues, juristes, vétérinaires, toxicologues, qui ont tous accepté la confrontation des disciplines et ce qu’elle implique d’atermoiements, de négociations, de renoncements. Le programme n’est que prétexte à une démarche réflexive dans laquelle l’auteur entraîne les acteurs de la recherche. L’ouvrage prend l’allure de récits où la dimension sensible devient essentielle, ce qui ne veut pas dire que leur travail n’est pas scientifique, mais témoigne de la présence déterminante de cette dimension, au même titre que la passion qui vibre à travers leurs paroles. L’ouvrage devient alors l’histoire des liens de cette communauté, une vision du vécu des chercheurs en regard de quelques grandes questions : la biodiversité, le terrain, l’interdisciplinarité, l’action. Tout au long de cette collecte de récits, Catherine Mougenot s’est efforcée en intervenant le moins possible de ne pas trahir les acteurs. Son écriture à chaud colle à l’expérience, jusqu’au moment où, du travail de montage de ces « histoires », l’auteur tire une analyse très pointue des propriétés du récit. Destiné à la communauté scientifique, cet ouvrage s’adresse également à tous ceux qui vivent la passion de la recherche comme une mise en intrigue. [less ▲]

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See detailAtlas linguistique de la Wallonie. Tome 17. Famille, vie et relations sociales
Baiwir, Esther ULg

Book published by PULg - Presses universitaires de Liège - Sciences Humaines (2011)

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See detailToothed whales in the northwestern Mediterranean: Insight into their feeding ecology using chemical tracers
Praca, Emilie; Laran, Sophie; Lepoint, Gilles ULg et al

in Marine Pollution Bulletin (2011), 62(5), 1058-1065

Risso’s dolphins, pilot whales and sperm whales rarely strand in the northwestern Mediterranean. Thus, their feeding ecology, through the analysis of stomach contents, is poorly known. The aim of this ... [more ▼]

Risso’s dolphins, pilot whales and sperm whales rarely strand in the northwestern Mediterranean. Thus, their feeding ecology, through the analysis of stomach contents, is poorly known. The aim of this study was to gain further insight into the segregation/superposition of the diet and habitat of Risso’s dolphins, pilot whales and sperm whales using chemical tracers, namely, stable isotopes (d13C, d15N) and orga- nochlorines. Significantly different d15N values were obtained in Risso’s dolphins (11.7 ± 0.7‰), sperm whales (10.8 ± 0.3‰) and pilot whales (9.8 ± 0.3‰), revealing different trophic levels. These differences are presumably due to various proportions of Histioteuthidae cephalopods in each toothed whale’s diet. Similar d13C contents between species indicated long-term habitat superposition or corroborated impor- tant seasonal migrations. Lower congener 180 concentrations (8.20 vs. 21.73 lg.g􏰀1 lw) and higher tDDT/ tPCB ratios (0.93 vs. 0.42) were observed in sperm whales compared with Risso’s dolphins and may indi- cate wider migrations for the former. Therefore, competition between these species seems to depend on different trophic levels and migration patterns. [less ▲]

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See detailLes Enjeux de la Mobilisation des Parties Prenantes dans un Processus de Certification Sociale. Le Cas d’un Call Center
El Abboubi, Manal ULg; Cornet, Annie ULg

in Revue Internationale P.M.E. (2011)

La présente recherche vise à comprendre le processus de mobilisation des parties prenantes dans une PME qui a initié un projet de certification sociale. La revue de littérature de la théorie des parties ... [more ▼]

La présente recherche vise à comprendre le processus de mobilisation des parties prenantes dans une PME qui a initié un projet de certification sociale. La revue de littérature de la théorie des parties prenantes explore et analyse les relations entre l’organisation et ses parties prenantes en mettant l’organisation dans une posture de réactivité face aux différentes pressions qu’elle reçoit de ses parties prenantes. Nous nous plaçons à l’opposé de cette posture en mettant l’organisation dans un rôle proactif dans lequel elle tente de mobiliser ses parties prenantes autour d’un projet de responsabilité sociale initié par elle-même. Très peu d’études académiques se sont intéressées à ce scénario, notre article souhaite ainsi combler le vide existant dans la littérature. En combinant différentes théories mobilisées pour analyser le positionnement des parties prenantes et la sociologie de la traduction, nous élaborons une grille d’analyse de ce processus d’implication qui débouche sur des propositions managériales. [less ▲]

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See detailPolarization measurement with space-variant retarders in liquid crystal polymers
Piron, Pierre ULg; Blain, Pascal ULg; Habraken, Serge ULg

in SPIE proceedings 8160, SPIE Optics +Photonics 2011 San Diego (2011)

We present a real-time polarization measurement method with a space-variant phase retarder in liquid crystal polymers. This retarder presents a continuous and periodical variation of its optical axis ... [more ▼]

We present a real-time polarization measurement method with a space-variant phase retarder in liquid crystal polymers. This retarder presents a continuous and periodical variation of its optical axis orientation. The method computes the Stokes parameters of an incident beam by studying the intensity distribution after the retarder and a linear polarizer. This paper contains the mathematical modelization, the numerical simulation, the description of the experimental setup, the results for several completely polarized beams and the future developments of this method. [less ▲]

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See detailInvestigation of human JC and BK polyomaviruses in breast carcinomas
Hachana, Mohamed Ridha ULg; Amara, Khaled; Ziadi, Sonia et al

in Breast Cancer Research and Treatment (2011)

We have previously showed the presence of the simian virus 40 (SV40) and the mouse mammary tumor virus (MMTV)-like in a significant proportions of Tunisian breast carcinomas. However, to date there are no ... [more ▼]

We have previously showed the presence of the simian virus 40 (SV40) and the mouse mammary tumor virus (MMTV)-like in a significant proportions of Tunisian breast carcinomas. However, to date there are no published studies concerning evaluation of the possible implication of the human polyomaviruses JC (JCV) and BK (BKV) in breast carcinomas. The presence of JCV and BKV DNA was investigated by PCR in a 123 primary breast carcinomas and matched adjacent non-tumor breast tissues. The results were correlated to clinicopathological and virological parameters. JCV T-antigen DNA was detected in 23% of breast carcinoma cases; however, all cases were negative for BKV. JCV T antigen PCR products were further confirmed as authentic JCV genome by direct sequencing. JCV was found in invasive ductal carcinomas (28/112 cases) but not in invasive lobular carcinomas (0/5) or medullary carcinomas (0/6). JCV DNA presence correlates inversely with the expression of estrogen (P = 0.022) and progesterone (P = 0.008) receptors. JCV DNA presence correlates also with "triple negative" phenotype (P = 0.021). With regard to virological data, a trend toward an inverse correlation was noted between the presence of JCV and SV40 (P = 0.06). Moreover, significant correlation was found between multiple viral infection (JCV, and/or SV40, and/or MMTV-like in the same tumor) and "triple negative" phenotype (P = 0.001) and also with p53 accumulation (P = 0.028). To the best of our knowledge, this is the first study demonstrating the presence of JCV in a subset of breast carcinomas. Also our results suggest that "triple negative" breast carcinomas are viral-related tumors. [less ▲]

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See detailDe la structure au lecteur et du code à la fiction : une brève histoire du "récit d'information"
Servais, Christine ULg

in Quaderni : la Revue de la Communication (2011), 74

Depuis la parution en 1966 de L’analyse structurale du récit, l’usage que fait le discours d’information du récit a donné lieu à un très grand nombre de travaux. Emportée par ce succès, la notion de récit ... [more ▼]

Depuis la parution en 1966 de L’analyse structurale du récit, l’usage que fait le discours d’information du récit a donné lieu à un très grand nombre de travaux. Emportée par ce succès, la notion de récit y subit par ailleurs un fléchissement conceptuel qui peut aller jusqu’à désigner la « super forme » implicite à laquelle les médias de masse renverraient nécessairement lorsqu’ils relaient événements ou informations. Un important ensemble de recherches ( inspirées des théories littéraires, notamment la narratologie, des recherches sur le récit « postmoderne » ou, plus récemment, du travail de Paul Ricoeur ou Michel de Certeau sur les liens entre récit et vie quotidienne), ont fait évoluer la manière dont la catégorie « récit » est susceptible de questionner le discours d’information. Cet article propose une lecture épistémologique de cette évolution, et rend compte des conditions d’émergence des enjeux actuellement questionnés dans l’étude des récits d’information. Il montre comment se sont imposées les questions liant récit, mythe et histoire collective puis, plus récemment, récit et fiction, et expose les raisons pour lesquelles, aujourd’hui, ces questions sont déportées vers une approche plus pragmatique, centrée sur la narration en tant qu’elle est un processus de médiation. L’ensemble de ces réflexions impose de clarifier une situation notionnelle parfois confuse ; l’article propose ainsi de réarticuler ensemble récit et narration en leur adjoignant la notion de récitation. [less ▲]

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See detailCross-reactivity of 25-hydroxy vitamin D2 from different commercial immunoassays for 25-hydroxy vitamin D: an evaluation without spiked samples.
CAVALIER, Etienne ULg; WALLACE, A. Michael; CARLISI, Ignazia ULg et al

in Clinical chemistry and laboratory medicine : CCLM / FESCC (2011), 49(3), 555-8

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See detailYoung pigeon disease syndrome
Duchatel, Jean-Pierre ULg; Szeleszczuk, P.

in Medycyna Weterynaryjna (2011), 67(5), 291-294

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