References of "2011"
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See detailReview of Dear Charles, Dear Janet: Frame and Brasch in Correspondence
Delrez, Marc ULg

in Commonwealth : Essays and Studies (2011), 33.2(Spring 2011), 151-153

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See detailLe cas clinique du mois : intoxication accidentelle à dose potentiellement létale d'acide borique
LOMBARD, Xavier ULg; benoit, A.; Ghuysen, Alexandre ULg et al

in Revue Médicale de Liège (2011), 66(12), 608-10

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See detailBrain functional integration decreases during propofol-induced loss of consciousness.
Schrouff, Jessica ULg; Perlbarg, Vincent; Boly, Mélanie ULg et al

in NeuroImage (2011), 57(1), 198-205

Consciousness has been related to the amount of integrated information that the brain is able to generate. In this paper, we tested the hypothesis that the loss of consciousness caused by propofol ... [more ▼]

Consciousness has been related to the amount of integrated information that the brain is able to generate. In this paper, we tested the hypothesis that the loss of consciousness caused by propofol anesthesia is associated with a significant reduction in the capacity of the brain to integrate information. To assess the functional structure of the whole brain, functional integration and partial correlations were computed from fMRI data acquired from 18 healthy volunteers during resting wakefulness and propofol-induced deep sedation. Total integration was significantly reduced from wakefulness to deep sedation in the whole brain as well as within and between its constituent networks (or systems). Integration was systematically reduced within each system (i.e., brain or networks), as well as between networks. However, the ventral attentional network maintained interactions with most other networks during deep sedation. Partial correlations further suggested that functional connectivity was particularly affected between parietal areas and frontal or temporal regions during deep sedation. Our findings suggest that the breakdown in brain integration is the neural correlate of the loss of consciousness induced by propofol. They stress the important role played by parietal and frontal areas in the generation of consciousness. [less ▲]

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See detailMiradas que se cruzan desde España. El entusiasmo de Manuel Vázquez Montalbán y la crítica de Ignacio Vidal-Folch
Vanden Berghe, Kristine ULg

in Vanden Berghe, Kristine; Huffshmid, Anne; Lefere, Robin (Eds.) EL EZLN y sus intérpretes. Resonancias del zapatismo en la academia y en la literatura. (2011)

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See detailCharacterization of the response of GFP microbial biosensors sensitive to substrate limitation in scale-down bioreactors
Delvigne, Frank ULg; Brognaux, Alison ULg; Gorret, Nathalie et al

in Biochemical Engineering Journal (2011), 55(2), 131-139

The dynamics of microbial stress response in intensive cultivation conditions remains not completely understood. In this work, two green fluorescent protein (GFP) transcriptional reporters have been used ... [more ▼]

The dynamics of microbial stress response in intensive cultivation conditions remains not completely understood. In this work, two green fluorescent protein (GFP) transcriptional reporters have been used as biosensors of the heterogeneities generated in a two-compartment scale-down reactor. The stress promoters have been chosen for their responsiveness to carbon limitation corresponding to the global substrate profiles encountered in intensive fed-batch cultures. From our results, it can be concluded that the exposure of microbial cells to substrates heterogeneities tends to decrease the GFP expression level in fed-batch mode. Fluorescence intensities have been monitored at the single cell level by using flow cytometry. During the course of the fed-batch culture, a drop at the level of the intracellular GFP content has been observed for the two scale-down operating conditions and for the two promoters sensitive to substrate limitation (rpoS and csiE). The fluorescence drop can be attributed to the repression of these promoters but also to the release of GFP to the extracellular medium according to the increase of the fluorescence level of the supernatant. This leakage has been observed for all the operating conditions, i.e. the scale-down reactors and the culture operating in the normal mode, i.e. in a well-mixed bioreactor. Interestingly, GFP leakage is more pronounced in the case of the cultures operated in the normal mode. Indeed, staining by propidium iodide tends to be more elevated for the microbial cells cultured under the normal mode by comparison with those cultured in scale-down conditions, indicating a higher permeability of the membrane. These results suggest that GFP microbial biosensors could be used to detect simultaneously mixing imperfections and their impact on the viability of microorganisms. [less ▲]

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See detailEnd of life care in the operating room for non-heart-beating donors: organization at the University Hospital of Liege.
JORIS, Jean ULg; KABA, Abdourahmane ULg; LAUWICK, Séverine ULg et al

in Transplantation Proceedings (2011), 43(9), 3441-4

Non-heart-beating (NHB) organ donation has become an alternative source to increase organ supply for transplantation. A NHB donation program was implemented in our institution in 2002. As in many ... [more ▼]

Non-heart-beating (NHB) organ donation has become an alternative source to increase organ supply for transplantation. A NHB donation program was implemented in our institution in 2002. As in many institutions the end of life care of the NHB donor (NHBD) is terminated in the operating room (OR) to reduce warm ischemia time. Herein we have described the organization of end of life care for these patients in our institution, including the problems addressed, the solution proposed, and the remaining issues. Emphasis is given to our protocol elaborated with the different contributors of the chain of the NHB donation program. This protocol specifies the information mandatory in the medical records, the end of life care procedure, the determination of death, and the issue of organ preservation measures before NHBD death. The persisting malaise associated with NHB donation reported by OR nurses is finally documented using an anonymous questionnaire. [less ▲]

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See detailLe trésor des rois de France de François Ier à Henri IV
Fagnart, Laure ULg

in Jullian, Martine (Ed.) Catalogue de l'exposition D'ombre et de lumière. Trésors sacrés, trésors profanes (Musée de Saint-Antoine-l'Abbaye, 10 juillet-9 octobre 2011) (2011)

À la Renaissance, le trésor ne disparaît pas au profit de la collection, telle qu’elle se (re)déploie à partir de la seconde moitié du XIVe siècle. En témoigne le trésor que les rois de France ont détenu ... [more ▼]

À la Renaissance, le trésor ne disparaît pas au profit de la collection, telle qu’elle se (re)déploie à partir de la seconde moitié du XIVe siècle. En témoigne le trésor que les rois de France ont détenu au XVIe siècle. Sous le règne de François Ier, les pièces précieuses et coûteuses sont conservées dans le château de Blois, puis dans la chambre du trésor des bagues de Fontainebleau. Sous Charles IX, quand sévissent les guerres de religion, le trésor est mis à l’abri dans la forteresse de la Bastille. Il n’en n’est pas pour autant progressivement démembré : donnés ou envoyés à la fonte, de nombreux objets quittent alors le domaine royal. Quand Henri IV monte sur le trône de France, le trésor des rois Valois a pratiquement disparu. Pour le reconstituer, le premier Bourbon puise dans le trésor des rois de Navarre, qui devient ainsi le trésor des rois de France. Comme auparavant, tout en donnant à voir le faste de la cour et sa puissance, le trésor constitue donc une réserve de matières précieuses que l’on peut, au besoin, monnayer, offrir, fondre ou mettre en gage. Progressivement toutefois, il convient de démontrer aussi son savoir culturel. Dès lors, d’autres objets forcent l’admiration. Il s’agit de petites antiquités, de naturalia, d’objets exotiques, mais aussi de tableaux et de sculptures, c’est-à-dire des pièces dont la valeur est désormais plutôt déterminée par l’esthétique ou par l’origine lointaine et mystérieuse que par la préciosité du matériau utilisé pour sa confection. [less ▲]

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See detailProspects for harmonized biodiversity assessments using national forest inventory data
McRoberts, Ronald E.; Chirici, Gherardo; Winter, Susanne et al

in Chirici, Gherardo; Winter, Susanne; McRoberts, Ronald E. (Eds.) National Forest Inventories - contributions to Forest Biodiversity Assessments (2011)

After selection of the 13 biodiversity variables (Sect. 2.3) based on their importance and feasibility for assessment by NFIs, responses were solicited from participating countries regarding the degree to ... [more ▼]

After selection of the 13 biodiversity variables (Sect. 2.3) based on their importance and feasibility for assessment by NFIs, responses were solicited from participating countries regarding the degree to which the variables are now assessed. Two conclusions were evident: (1) most countries currently assess most of the variables, but (2) consensus is lacking on assessment methods and necessary field crew expertise, suggesting that harmonization would require emphasis on field operations. For each of the seven essential features into which the 13 variables were grouped, more detailed assessments were conducted. For forest categories, the conclusion was that the only major difference in classification systems used by European NFIs was whether potential or actual vegetation was used to define classes. Thus, the prospects for harmonization of forest categories are considered excellent. For forest structure, the prospects depend on the variable. For tree species, the prospects are excellent because the variable is assessed in the same manner by all NFIs. For dbh and height, considerable variability in measurementthresholds were found, but otherwise the harmonization prospects are good. For social position, definitions of classes varied, but harmonized estimates of proportions for dominant, intermediate, and suppressed classes are considered possible. Prospects for harmonized estimates of layers are consideraly poorer because of different definitions, thresholds and the uncertainty associated with visual assessment methods. Harmonized estimation of forest age is impeded by the increasing proportion of uneven-aged stands for which age is often not assessed, different definitions, and different assessment methods. However, agreement on dominant age as a reference definition would greatly increase the prospects. Deadwood is becoming an increasingly popular indicator of sustainable forest management. Unfortunately, considerable variability was found in deadwood definitions, components (e.g., stumps, limbs), sampling methods, and measurement thresholds. Thus, harmonized deadwood estimation will require development of bridges. Harmonization of regeneration estimates faces challenges due to differences in assessment approaches such as presence/absence versus coverage and all species versus dominant species. Harmonized estimation may be restricte to change in regeneration success. Harmonized estimation for ground vegetation also faces serious challenges due to differences in the components assessed (e.g., small trees, shrubs, herbs, bryophytes, lichens), difference in height thresholds, and differences in categories for which ground vegetation is reported. Forest naturalness integrates many of the other essential feature. However, many countries do not assess naturalness, and among those that do, assessment variables, methods, and reporting classes vary considerably. For harmonized assessment using NFI variables, the hemeroby approach, which emphasizes indications of human influence, is extremely sensitive to plot size. Harmonization using the ecosystem processes approach requires a common dbh threshold and similar plot sizes. The overall conclusion is that harmonization will be considerably easier for some essential features than for others. The factors leading to difficulties often are related to different definitions, different reporting classes, different measurement thresholds, and different features of sampling protocols such as plot sizes and configurations. Nevertheless, construction of reference definitions and bridges greatly facilitate harmonization for all essential features as is illustrated in Chap. 5. [less ▲]

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See detailNew method to combine molecular and pedigree relationships
Bömcke, Elisabeth ULg; Soyeurt, Hélène ULg; Szydlowski, Maciej et al

in Journal of Animal Science (2011), 89

Relationship coefficients are traditionally based on pedigree data. Today, with the development of molecular techniques, they are often completely replaced by coefficients calculated from molecular data ... [more ▼]

Relationship coefficients are traditionally based on pedigree data. Today, with the development of molecular techniques, they are often completely replaced by coefficients calculated from molecular data. Examples are relationships from microsatellites for biodiversity studies but also genomic relationships from SNP as currently used in genomic prediction of breeding values. There are, however, many situations in which optimal combination of both sources would be the best solutions. Obviously, this is the case for incompletely genotyped populations, but also when pedigree information is sparse. Also, markers, even dense ones, do not reflect the whole genome and therefore give only an incomplete picture of relationships. The main objective of this study was therefore to develop a method to calculate a relationship matrix by the combination of molecular and pedigree data. It will be useful for all situations where pedigree and molecular data are available. In this study, based on simulations of pedigree and marker data, we used partial least squares regression and linear regression to combine total allelic relationship coefficients calculated for each marker with additive relationship coefficients calculated from incomplete pedigree. The results showed that the greatest advantage of this method, compared with the one that replaces a part of the pedigree-based relationship matrix by a genomic relationship matrix, is that adding the partial pedigree data allows for the correction of the molecular coefficient for the ungenotyped part of the genome. [less ▲]

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See detailLe secteur privé à la rescousse de la faune sauvage en Afrique de l’Ouest. Evaluation écologique et économique de la Zone de Chasse de Konkombouri au Burkina Faso
Bouché, Philippe ULg; Lungren, Clark; Moumouni, Dermé

in Parcs & Réserves (2011), 66(4), 12-22

Le Burkina Faso, s’est engagé depuis plusieurs années dans le domaine de la conservation de la Nature, mais souffre du manque de moyens nécessaires pour entretenir et développer son potentiel faunique. En ... [more ▼]

Le Burkina Faso, s’est engagé depuis plusieurs années dans le domaine de la conservation de la Nature, mais souffre du manque de moyens nécessaires pour entretenir et développer son potentiel faunique. En 1996, le Burkina Faso s’est engagé dans une réforme inédite dans ce pays visant à ouvrir la gestion de la faune au secteur privé. Cet article présente à travers l’exemple de la Zone de Chasse de Konkombouri comment le concessionnaire a pu, en mettant en œuvre un certain nombre d’aménagements et certaines activités de gestion de terrain, redynamiser la faune qui s’est multipliée par 3 en 12 ans et comment l’activité de grande chasse a pu créer une dynamique économique favorable à l’Etat, aux communautés locales et aux prestataires de services locaux et étrangers. L’analyse économique compare également les résultats économiques de la ZCK à d’autres zones de chasse d’Afrique Centrale et de l’Ouest. [less ▲]

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See detailImpact of chronic graft-versus-host disease (GVHD) after reduced intensity conditioning (RIC) allogeneic stem cell transplantation (allo-SCT) as treatment for acute myeloid leukemia (AML) : a survey from the Acute Leukemia Working Party of the EBMT
Baron, Frédéric ULg; Labopin, Myriam; Niederwieser, Dietger et al

in Blood (2011), 118

The goal of RIC allo-SCT is to harness the graft-versus-leukemia (GVL) effect, while minimizing toxicities and the risk of GVHD. However, prior studies have shown a lower risk of relapse in AML patients ... [more ▼]

The goal of RIC allo-SCT is to harness the graft-versus-leukemia (GVL) effect, while minimizing toxicities and the risk of GVHD. However, prior studies have shown a lower risk of relapse in AML patients (pts) who experienced chronic GVHD after RIC allo-SCT versus in those who did not. Here, we investigated the impact of occurrence of GVHD on transplantation outcomes in a large cohort of AML pts given allogeneic PBSC after RIC conditioning. Data from 1859 AML pts in first (n=1439) or second (n=420) CR transplanted between 2000 and 2009 following a RIC regimen at EBMT affiliated centres were analyzed. Pts were given PBSC from HLA-identical sibling (MRD, n=1208), or from HLA-matched unrelated donors (MUD, n=651). Median pt age at transplantation was 56 y (range, 18–77). 338 male pts were given grafts from female donors. RIC was based on low-dose TBI in 520 (28%) pts, while the remaining pts received chemotherapy-based RIC. ATG was given in 269 (22%) MRD and in 267 (41%) MUD recipients, respectively, while 151 (13%) MRD and 165 (25%) MUD recipients received in-vivo T cell depletion with alemtuzumab. The impact of chronic GVHD on relapse risk, non-relapse mortality (NRM), leukemia-free survival (LFS), and overall survival (OS) was assessed using time-dependent multivariate Cox models and in a landmark analysis at 18 months after transplant. Three-year incidences of relapse, NRM, LFS and OS were 34±1%, 15±1%, 51±2% and 60±2% in MRD recipients, respectively, and 34±2% (p=NS), 24±2% (P<0.001), 42±2% (P=0.001) and 47±2% (P=0.001) in MUD recipients, respectively. Grade II, III and IV acute GVHD were observed in 133 (11%), 61 (5%) and 30 (2%) MRD recipients and in 119 (18%), 41 (6%) and 24 (4%) MUD recipients, respectively. The 3-y cumulative incidence of chronic GVHD was 47%. Fifty-three percent of patients with chronic GVHD had extensive chronic GVHD, while the remaining 47% had limited chronic GVHD. In multivariate analyses, occurrence of grade II-IV acute GVHD was associated with a lower risk of relapse (HR=0.8; P=0.04), a higher risk of chronic (HR=2.2; P<0.001) and extensive chronic GVHD (HR=2.8; P<0.001), a higher risk of NRM (HR=2.4 P<0.001), a worsened LFS (HR=1.3; P=0.01), and a worsened OS (HR=1.5; P<0.001). In multivariate time-dependent analyses, occurrence of limited chronic GVHD was associated with a lower risk of relapse (HR=0.7; P=0.05), comparable NRM (HR=1.4; P=0.16), comparable LFS (HR=0.9; P=0.29) and better OS (HR=0.5; P<0.001), while occurrence of extensive chronic GVHD was associated with a lower risk of relapse (HR=0.6; P=0.01), higher NRM (HR=3.2; P<0.001), a trend for worsened LFS (HR=1.3; P=0.06) and comparable OS (HR=0.9; P=0.34). The median interval from transplantation to occurrence of chronic GVHD was 163 (range, 100–1545) days. To further assess the graft-versus-leukemia effect of chronic GVHD, we performed a landmark analysis in patients who were leukemia-free at 18 months after transplantation (n=776). Median follow-up from this landmark time-point was 24 (range, 0.1–112) months. Two-year relapse, NRM, LFS and OS were 16±2%, 2.5±1%, 82±2%, and 89±2%, respectively, in patients without chronic GVHD before the landmark time-point, versus 9±1% (P=0.001), 8±1% (P<0.001), 83±2% (P=0.65), and 86±2% (P=0.38), respectively, in patients with chronic GVHD before the landmark time-point.In conclusion, in this cohort of AML patients transplanted in remission, occurrence of chronic GVHD was associated with a lower risk of relapse that translated to better OS in patients with limited chronic GVHD but not in those with extensive chronic GVHD who experienced higher long term NRM, highlighting the need for long term prospective assessment of long term effects and quality of life in patients receiving RIC allo-SCT. [less ▲]

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See detailSex and PRNP genotype determination in preimplantation caprine embryos
Guignot, F.; Perreau, C.; Cavarroc, C. et al

in Reproduction in Domestic Animals (2011), 46(4), 656-663

The objective of this study was to test the accuracy of genotype diagnosis after whole amplification of DNA extracted from biopsies obtained by trimming goat embryos and to evaluate the viability of ... [more ▼]

The objective of this study was to test the accuracy of genotype diagnosis after whole amplification of DNA extracted from biopsies obtained by trimming goat embryos and to evaluate the viability of biopsied embryos after vitrification/warming and transfer. Whole genome amplification (WGA) was performed using Multiple Displacement Amplification (MDA). Sex and prion protein (PRNP) genotypes were determined. Sex diagnosis was carried out by PCR amplification of ZFX/ZFY and Y chromosome-specific sequences. Prion protein genotype determination was performed on codons 142, 154, 211, 222 and 240. Embryos were collected at day 7 after oestrus and biopsied either immediately after collection (blastocysts and expanded blastocysts) or after 24 h of in vitro culture (compacted morulae). Biopsied embryos were frozen by vitrification. Vitrified whole embryos were kept as control. DNA of biopsies was extracted and amplified using MDA. Sex diagnosis was efficient for 97.4% of biopsies and PRNP genotyping was determined in 78.7% of biopsies. After embryo transfer, no significant difference was observed in kidding rate between biopsied and vitrified control embryos, whereas embryo survival rate was different between biopsied and whole vitrified embryos (p = 0.032). At birth, 100% of diagnosed sex and 98.2% of predetermined codons were correct. Offspring PRNP profiles were in agreement with parental genotype. Whole genome amplification with MDA kit coupled with sex diagnosis and PRNP genotype predetermination are very accurate techniques to genotype goat embryos before transfer. These novel results allow us to plan selection of scrapie-resistant genotypes and kid sex before transfer of cryopreserved embryo. [less ▲]

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See detailTheories of mind and personal epistemology: their interrelation and connection with the concept of metacognition.
Fagnant, Annick ULg; Crahay, Marcel ULg

in European Journal of Psychology of Education [=EJPE] (2011), 26(2), 257-271

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See detailEtude de l'activité antifongique des bactéries lactiques isolées de produits alimentaires fermentés et caractérisation de leurs métabolites inhibiteurs
Ndagano, Dora ULg

Doctoral thesis (2011)

Summary: The aim of this present research was to study the antifungal properties of lactic acid bacteria (LAB) isolated from fermented Mill flour and fermented cassava in order to use them for ... [more ▼]

Summary: The aim of this present research was to study the antifungal properties of lactic acid bacteria (LAB) isolated from fermented Mill flour and fermented cassava in order to use them for biopreservation. Antifungal activity of these LAB were assessed in MRS solid medium against food spoilage moulds as Aspergillus niger MUCL 28699, Aspergillus niger CWBIF194, Aspergillus tubingensis MP1 and Penicillium crustosum MY1. Three strains, Lactobacillus plantarum VE56, Weissella cibaria FMF4B16 and Weissella paramesenteroides LC11 were selected among 116 for their strongest inhibitory activity and their broad inhibitory spectrum against food moulds. The 4-fold concentrated supernatant of L. plantarum VE56 and W. paramesenteroides LC11 had the strongest inhibitory activity to compare to W. cibaria FMF4B16. The antifungal activity of the cell-free supernatant was pH dependent and insensitive to proteolytic enzymes action suggesting that the inhibitory activity was due to other compounds than proteins. The identification of antifungal compounds by chromatographic studies highlighted the production of phenyllactic acid by the three strains. In addition, 2-hydroxy-3-methylpentanoic acid and 2-hydroxy-4-methylpentanoic acid were produced by L. plantarum VE56 and W. paramesenteroides LC11. However, the concentration assessed in the supernatant was lower than the minimal inhibitory concentration showing a synergic action of all these produced compounds. The effect of the antifungal supernatant of L. plantarum VE56 and W. paramesenteroides LC11 on Aspergillus flavus NRRL 3357 resulted to an inhibition of conidial development and aflatoxin B1 production which was reflected in decreased gene expression of brlA (conidiophore specific transcription factor) and laeA (global regulator of secondary metabolism). These two bacteria also delayed Penicillium expansum MUCL 14498 conidial development in bread. [less ▲]

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See detailActors' benefit analysis on value chain of fresh dairy milk in Vietnam
Tran Huu; Bui, Thi Nga ULg

in Journal of Economics & Development (2011), (169(II)), 32-38

Vietnam locates in the Asia-the most active region, where gains the highest economic growth rate and highest milk consumption in the world. Vietnam also ranks the second among the highest milk ... [more ▼]

Vietnam locates in the Asia-the most active region, where gains the highest economic growth rate and highest milk consumption in the world. Vietnam also ranks the second among the highest milk productivity in the Asia and milk consumption is increasing rapidly. However, the dairy industry in Vietnam is currently able to meet only 22% of domestic demand; the remaining amount has been imported (VOV/VNA, 2008). In addition, raw milk price is very low while retail price is too high. It leads to low effective in the production of the whole chain. This paper is based on the value chain approach within both quantitative and qualitative methods to evaluate a typical fresh value chain in the North of Vietnam in (Moc Chau platation) in 2008 - 2010. The findings show that the dairy plant is the most powerful actor in the chain and it drives the whole chain while power of dairymen is very weak. The value added of the chain is distributed unequally among its actors in whom more benefitable for non-dairy cow producers. In particular, the value added in dairy cow stage would be much lower. [less ▲]

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See detailComparison of the Full Outline of UnResponsiveness and Glasgow Liege Scale/Glasgow Coma Scale in an Intensive Care Unit Population.
Bruno, Marie-Aurélie ULg; LEDOUX, Didier ULg; LAMBERMONT, Bernard ULg et al

in Neurocritical Care (2011), 15(3), 447-53

BACKGROUND: The Full Outline of UnResponsiveness (FOUR) has been proposed as an alternative for the Glasgow Coma Scale (GCS)/Glasgow Liege Scale (GLS) in the evaluation of consciousness in severely brain ... [more ▼]

BACKGROUND: The Full Outline of UnResponsiveness (FOUR) has been proposed as an alternative for the Glasgow Coma Scale (GCS)/Glasgow Liege Scale (GLS) in the evaluation of consciousness in severely brain-damaged patients. We compared the FOUR and GLS/GCS in intensive care unit patients who were admitted in a comatose state. METHODS: FOUR and GLS evaluations were performed in randomized order in 176 acutely (<1 month) brain-damaged patients. GLS scores were transformed in GCS scores by removing the GLS brainstem component. Inter-rater agreement was assessed in 20% of the studied population (N = 35). A logistic regression analysis adjusted for age, and etiology was performed to assess the link between the studied scores and the outcome 3 months after injury (N = 136). RESULTS: GLS/GCS verbal component was scored 1 in 146 patients, among these 131 were intubated. We found that the inter-rater reliability was good for the FOUR score, the GLS/GCS. FOUR, GLS/GCS total scores predicted functional outcome with and without adjustment for age and etiology. 71 patients were considered as being in a vegetative/unresponsive state based on the GLS/GCS. The FOUR score identified 8 of these 71 patients as being minimally conscious given that these patients showed visual pursuit. CONCLUSIONS: The FOUR score is a valid tool with good inter-rater reliability that is comparable to the GLS/GCS in predicting outcome. It offers the advantage to be performable in intubated patients and to identify non-verbal signs of consciousness by assessing visual pursuit, and hence minimal signs of consciousness (11% in this study), not assessed by GLS/GCS scales. [less ▲]

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