References of "2011"
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See detailL'esthétique phénoménologique de Husserl : une approche contrastée
Steinmetz, Rudy ULg

Book published by Kimé (2011)

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See detailDrospirenone and interference with renin-antiotensin system
VROONEN, Laurent ULg; Cavalier, Etienne ULg; Vranken, Laura ULg et al

in Annales d'Endocrinologie - 28ème congrès de la société Française d'Endocrinologie (2011)

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See detailImpact of chronic graft-versus-host disease (GVHD) after reduced intensity conditioning (RIC) allogeneic stem cell transplantation (allo-SCT) as treatment for acute myeloid leukemia (AML) : a survey from the Acute Leukemia Working Party of the EBMT
Baron, Frédéric ULg; Labopin, Myriam; Niederwieser, Dietger et al

in Blood (2011), 118

The goal of RIC allo-SCT is to harness the graft-versus-leukemia (GVL) effect, while minimizing toxicities and the risk of GVHD. However, prior studies have shown a lower risk of relapse in AML patients ... [more ▼]

The goal of RIC allo-SCT is to harness the graft-versus-leukemia (GVL) effect, while minimizing toxicities and the risk of GVHD. However, prior studies have shown a lower risk of relapse in AML patients (pts) who experienced chronic GVHD after RIC allo-SCT versus in those who did not. Here, we investigated the impact of occurrence of GVHD on transplantation outcomes in a large cohort of AML pts given allogeneic PBSC after RIC conditioning. Data from 1859 AML pts in first (n=1439) or second (n=420) CR transplanted between 2000 and 2009 following a RIC regimen at EBMT affiliated centres were analyzed. Pts were given PBSC from HLA-identical sibling (MRD, n=1208), or from HLA-matched unrelated donors (MUD, n=651). Median pt age at transplantation was 56 y (range, 18–77). 338 male pts were given grafts from female donors. RIC was based on low-dose TBI in 520 (28%) pts, while the remaining pts received chemotherapy-based RIC. ATG was given in 269 (22%) MRD and in 267 (41%) MUD recipients, respectively, while 151 (13%) MRD and 165 (25%) MUD recipients received in-vivo T cell depletion with alemtuzumab. The impact of chronic GVHD on relapse risk, non-relapse mortality (NRM), leukemia-free survival (LFS), and overall survival (OS) was assessed using time-dependent multivariate Cox models and in a landmark analysis at 18 months after transplant. Three-year incidences of relapse, NRM, LFS and OS were 34±1%, 15±1%, 51±2% and 60±2% in MRD recipients, respectively, and 34±2% (p=NS), 24±2% (P<0.001), 42±2% (P=0.001) and 47±2% (P=0.001) in MUD recipients, respectively. Grade II, III and IV acute GVHD were observed in 133 (11%), 61 (5%) and 30 (2%) MRD recipients and in 119 (18%), 41 (6%) and 24 (4%) MUD recipients, respectively. The 3-y cumulative incidence of chronic GVHD was 47%. Fifty-three percent of patients with chronic GVHD had extensive chronic GVHD, while the remaining 47% had limited chronic GVHD. In multivariate analyses, occurrence of grade II-IV acute GVHD was associated with a lower risk of relapse (HR=0.8; P=0.04), a higher risk of chronic (HR=2.2; P<0.001) and extensive chronic GVHD (HR=2.8; P<0.001), a higher risk of NRM (HR=2.4 P<0.001), a worsened LFS (HR=1.3; P=0.01), and a worsened OS (HR=1.5; P<0.001). In multivariate time-dependent analyses, occurrence of limited chronic GVHD was associated with a lower risk of relapse (HR=0.7; P=0.05), comparable NRM (HR=1.4; P=0.16), comparable LFS (HR=0.9; P=0.29) and better OS (HR=0.5; P<0.001), while occurrence of extensive chronic GVHD was associated with a lower risk of relapse (HR=0.6; P=0.01), higher NRM (HR=3.2; P<0.001), a trend for worsened LFS (HR=1.3; P=0.06) and comparable OS (HR=0.9; P=0.34). The median interval from transplantation to occurrence of chronic GVHD was 163 (range, 100–1545) days. To further assess the graft-versus-leukemia effect of chronic GVHD, we performed a landmark analysis in patients who were leukemia-free at 18 months after transplantation (n=776). Median follow-up from this landmark time-point was 24 (range, 0.1–112) months. Two-year relapse, NRM, LFS and OS were 16±2%, 2.5±1%, 82±2%, and 89±2%, respectively, in patients without chronic GVHD before the landmark time-point, versus 9±1% (P=0.001), 8±1% (P<0.001), 83±2% (P=0.65), and 86±2% (P=0.38), respectively, in patients with chronic GVHD before the landmark time-point.In conclusion, in this cohort of AML patients transplanted in remission, occurrence of chronic GVHD was associated with a lower risk of relapse that translated to better OS in patients with limited chronic GVHD but not in those with extensive chronic GVHD who experienced higher long term NRM, highlighting the need for long term prospective assessment of long term effects and quality of life in patients receiving RIC allo-SCT. [less ▲]

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See detailActors' benefit analysis on value chain of fresh dairy milk in Vietnam
Tran Huu; Bui, Thi Nga ULg

in Journal of Economics & Development (2011), (169(II)), 32-38

Vietnam locates in the Asia-the most active region, where gains the highest economic growth rate and highest milk consumption in the world. Vietnam also ranks the second among the highest milk ... [more ▼]

Vietnam locates in the Asia-the most active region, where gains the highest economic growth rate and highest milk consumption in the world. Vietnam also ranks the second among the highest milk productivity in the Asia and milk consumption is increasing rapidly. However, the dairy industry in Vietnam is currently able to meet only 22% of domestic demand; the remaining amount has been imported (VOV/VNA, 2008). In addition, raw milk price is very low while retail price is too high. It leads to low effective in the production of the whole chain. This paper is based on the value chain approach within both quantitative and qualitative methods to evaluate a typical fresh value chain in the North of Vietnam in (Moc Chau platation) in 2008 - 2010. The findings show that the dairy plant is the most powerful actor in the chain and it drives the whole chain while power of dairymen is very weak. The value added of the chain is distributed unequally among its actors in whom more benefitable for non-dairy cow producers. In particular, the value added in dairy cow stage would be much lower. [less ▲]

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See detailPre-study and in-study validation of a SPE-LC-MS-MS method for the determination of 5-S-cysteinyldopa, a melanoma biomarker, in human plasma.
Martin, Gaelle; Mansion, François ULg; Houbart, Virginie ULg et al

in Talanta (2011), 84(2), 280-6

The incidence of malignant melanoma has increased over the past decades, particularly in Caucasian population. This disease presents defavourable prognosis in terms of survey, especially when detection ... [more ▼]

The incidence of malignant melanoma has increased over the past decades, particularly in Caucasian population. This disease presents defavourable prognosis in terms of survey, especially when detection occurs at the metastatic phase. Reliable analytical methods for biomarker determination are thus an interesting tool in pathology detection and follow-up. In this context, a method using SPE-LC-ESI-MS-MS for the determination of 5-S-cysteinyldopa (5-SCD) in human plasma was optimized. The presence of matrix effect was investigated in details while 5-SCD stability was studied according to FDA requirements for the validation of bioanalytical methods. Pre-study and in-study validations of the entire method were then successfully performed by applying the approach based on total measurement error and accuracy profiles over a concentration ranges from 1.6 to 200 ng/ml. Good results with respect to accuracy, trueness and precision were obtained. The maximum risk of observing future measurements falling outside the acceptance limits during routine analysis was also estimated. [less ▲]

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See detailEtude de l'activité antifongique des bactéries lactiques isolées de produits alimentaires fermentés et caractérisation de leurs métabolites inhibiteurs
Ndagano, Dora ULg

Doctoral thesis (2011)

Summary: The aim of this present research was to study the antifungal properties of lactic acid bacteria (LAB) isolated from fermented Mill flour and fermented cassava in order to use them for ... [more ▼]

Summary: The aim of this present research was to study the antifungal properties of lactic acid bacteria (LAB) isolated from fermented Mill flour and fermented cassava in order to use them for biopreservation. Antifungal activity of these LAB were assessed in MRS solid medium against food spoilage moulds as Aspergillus niger MUCL 28699, Aspergillus niger CWBIF194, Aspergillus tubingensis MP1 and Penicillium crustosum MY1. Three strains, Lactobacillus plantarum VE56, Weissella cibaria FMF4B16 and Weissella paramesenteroides LC11 were selected among 116 for their strongest inhibitory activity and their broad inhibitory spectrum against food moulds. The 4-fold concentrated supernatant of L. plantarum VE56 and W. paramesenteroides LC11 had the strongest inhibitory activity to compare to W. cibaria FMF4B16. The antifungal activity of the cell-free supernatant was pH dependent and insensitive to proteolytic enzymes action suggesting that the inhibitory activity was due to other compounds than proteins. The identification of antifungal compounds by chromatographic studies highlighted the production of phenyllactic acid by the three strains. In addition, 2-hydroxy-3-methylpentanoic acid and 2-hydroxy-4-methylpentanoic acid were produced by L. plantarum VE56 and W. paramesenteroides LC11. However, the concentration assessed in the supernatant was lower than the minimal inhibitory concentration showing a synergic action of all these produced compounds. The effect of the antifungal supernatant of L. plantarum VE56 and W. paramesenteroides LC11 on Aspergillus flavus NRRL 3357 resulted to an inhibition of conidial development and aflatoxin B1 production which was reflected in decreased gene expression of brlA (conidiophore specific transcription factor) and laeA (global regulator of secondary metabolism). These two bacteria also delayed Penicillium expansum MUCL 14498 conidial development in bread. [less ▲]

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See detailRecollection and familiarity processes in probable Alzheimer's disease: an fMRI study
Genon, Sarah ULg; Collette, Fabienne ULg; Salmon, Eric ULg et al

in Proceedings of the 5th International Conference on Memory (2011)

Cerebral activity associated with recollection and familiarity in 28 patients with Alzheimer’s disease (AD) and 17 healthy controls was directly measured in an event-related fMRI experiment during ... [more ▼]

Cerebral activity associated with recollection and familiarity in 28 patients with Alzheimer’s disease (AD) and 17 healthy controls was directly measured in an event-related fMRI experiment during performance of a recognition memory task with the process dissociation procedure. Brain regions associated to recollection were evidenced by contrasting activations for inclusion and exclusion conditions whereas brain regions related to familiarity were explored with the mean effect of the two conditions (at P < .05 corrected). Twelve patients had null recollection estimates (AD-), whereas 16 patients did experience some recollection although significantly less than controls (AD+). In AD+ and controls, recollection activated the posterior cingulate cortex (PCC). In contrast, familiarity estimates were equivalent in the 3 groups and were associated with brain activations around the intraparietal sulcus (IPS). Thus, in AD, impaired recollection is related to damage of the PCC whereas preserved familiarity is supported by the IPS. [less ▲]

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See detailOnderneming en recht. Bedrijfsfiscaliteit
Peeters, Bart ULg

Book published by Knops Publishing (2011)

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See detailTraumatologie du golf
Kaux, Jean-François ULg; Crielaard, Jean-Michel ULg

Learning material (2011)

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See detailLa main de Gilliatt-Sumner ou le syndrome de défilé cervicothoracique neurogène vrai. A propos de sept cas opérés.
DUBUISSON, Annie ULg; NGUYEN KHAC, Minh-Tuan ULg; SCHOLTES, Félix ULg et al

in Neuro-Chirurgie (2011), 57(1), 9-14

BACKGROUND AND PURPOSE: The clinical picture of hand atrophy related to a cervical rib or elongated C7 transverse process was well described in the modern literature by Gilliatt and Sumner; in 1970, they ... [more ▼]

BACKGROUND AND PURPOSE: The clinical picture of hand atrophy related to a cervical rib or elongated C7 transverse process was well described in the modern literature by Gilliatt and Sumner; in 1970, they reported a series of nine patients whose motor status was stabilized following brachial plexus decompression. We report here seven patients suffering from thoracic outlet syndrome (TOS), who developed hand atrophy, sometimes because of diagnostic delay. METHODS: The patient's charts were analysed retrospectively. RESULTS: The seven patients were all female; the mean age was 43 years. The first complaints were arm pain and paresthesias lasting six months to 5 years. Three patients were treated with C56/C67 discectomy plus disc prosthesis (one patient), ulnar neurolysis at the elbow (the same patient), carpal tunnel release (one patient), and intravenous immunoglobulins (one patient) before TOS diagnosis. Hand atrophy, severe in five patients, was present at presentation. All patients underwent brachial plexus decompression by the anterior (four), posterior (two), or transaxillary (one) approach. This last approach was completed 18 months later by brachial plexus neurolysis via the anterior approach. Postoperatively, motor deficit was improved in two patients and stabilized in five patients. CONCLUSIONS: Physicians' unfamiliarity with TOS diagnosis or their reluctance to accept the diagnosis without electrical confirmation can lead to hand atrophy. Brachial plexus decompression at this stage usually stabilizes the deficit. [less ▲]

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See detailMalignant catarrhal fever induced by Alcelaphine herpesvirus 1 is characterized by an expansion of activated CD3+CD8+CD4- T cells expressing a cytotoxic phenotype in both lymphoid and non-lymphoid tissues.
Dewals, Benjamin G ULg; Vanderplasschen, Alain ULg

in Veterinary research (2011), 42(1), 95

ABSTRACT: Alcelaphine herpesvirus 1 (AlHV-1) is carried by wildebeest asymptomatically. It causes a fatal lymphoproliferative disease named wildebeest-derived malignant catarrhal fever (WD-MCF) when cross ... [more ▼]

ABSTRACT: Alcelaphine herpesvirus 1 (AlHV-1) is carried by wildebeest asymptomatically. It causes a fatal lymphoproliferative disease named wildebeest-derived malignant catarrhal fever (WD-MCF) when cross-species transmitted to a variety of susceptible species of the Artiodactyla order. WD-MCF can be reproduced experimentally in rabbits. In a previous report, we demonstrated that WD-MCF induced by AlHV-1 is associated with a severe proliferation of CD8+ T cells in the lymphoid tissues. Here, we further studied the mononuclear leukocytic populations in both the lymphoid (throughout the infection and at time of euthanasia) and non-lymphoid (at time of euthanasia) organs during WD-MCF induced experimentally in rabbits. To reach that goal, we performed multi-colour flow cytometry stainings. The results obtained demonstrate that the development of WD-MCF correlates in peripheral blood with a severe increase of CD8+ cell percentages; and that CD3+CD8+CD4- T cells were the predominant cell type in both lymphoid and non-lymphoid organs at time of euthanasia. Further characterization of the mononuclear leukocytes isolated from both lymphoid and non-lymphoid tissues revealed that the CD8+ T cells express high levels of the activation markers CD25 and CD44, produce high amount of gamma-interferon (IFN-gamma) and perforin, and showed a reduction of interleukin-2 (IL-2) gene expression. These data demonstrate that the development of WD-MCF is associated with the expansion and infiltration of activated and cytotoxic CD3+CD8+CD4- T cells secreting high amount of IFN-gamma but low IL-2. [less ▲]

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See detailProgramme interrégional de prévention et de promotion de la santé mentale : fondements d'une méthode d'évaluation
Absil, Gaëtan ULg; Govers, Patrick ULg; Fond-Harmant, Laurence et al

Diverse speeche and writing (2011)

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See detailDeforestation in Central and West Africa: landscape dynamics, anthropogenic effects and ecological consequences.
Barima, Y S S; Djibu, J P; Alongo, S et al

in Daniels, J A (Ed.) Advances in Environmental Research - Volume 7 (2011)

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See detailBRYOPHYTES DU PARC NATIONAL DU MERCANTOUR : METHODES ET RESULTATS DE LA CAMPAGNE D'INVENTAIRES 2010 ATBI+M
Saatkamp, Arne; Aleffi, Michele; de Biaggi, Marta et al

in Biocosme Mesogeen (2011), 28(2), 23-50

During the All Taxa Biodiversity Inventory + Monitoring programme (ATBI+M) in the Mercantour and Alpi Marittime National Parks, our inventories of bryophytes identified 234 taxa (mosses and liverworts ... [more ▼]

During the All Taxa Biodiversity Inventory + Monitoring programme (ATBI+M) in the Mercantour and Alpi Marittime National Parks, our inventories of bryophytes identified 234 taxa (mosses and liverworts). This work completes the previous field campaigns, notably those of Jean-Pierre Hebrard (I MEP, Marseille) since 1965, and the ATBI bryophyte inventories in 2007. This number is based on four days of inventories in the central and peripheric territory of both National Parks, in four days in July and August 2010, together with previous data the 565 taxa known from the area still underestimate the number of species actually present. Our observations in 2010 added several new species for this area, including several rare and remarkable species such as Haplomitrium hookeri or species listed under the Habitats Directive as Buxbaumia viridis and Orthotrichum rogeri. Given the rarity of their habitats species from snow beds, large block boulders and high altitude wetlands are most remarkable. [less ▲]

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See detailTropical forest carbon stocks estimates. Is tree aboveground biomass variability at the landscape scale really non-significant in a REDD+ context?
Bastin, Jean-François ULg; Bogaert, Jan ULg; De Cannière, C

in Research Priorities in Tropical Silviculture: Towards New Paradigms? (2011)

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