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See detailImpact of chronic graft-versus-host disease (GVHD) after reduced intensity conditioning (RIC) allogeneic stem cell transplantation (allo-SCT) as treatment for acute myeloid leukemia (AML) : a survey from the Acute Leukemia Working Party of the EBMT
Baron, Frédéric ULg; Labopin, Myriam; Niederwieser, Dietger et al

in Blood (2011), 118

The goal of RIC allo-SCT is to harness the graft-versus-leukemia (GVL) effect, while minimizing toxicities and the risk of GVHD. However, prior studies have shown a lower risk of relapse in AML patients ... [more ▼]

The goal of RIC allo-SCT is to harness the graft-versus-leukemia (GVL) effect, while minimizing toxicities and the risk of GVHD. However, prior studies have shown a lower risk of relapse in AML patients (pts) who experienced chronic GVHD after RIC allo-SCT versus in those who did not. Here, we investigated the impact of occurrence of GVHD on transplantation outcomes in a large cohort of AML pts given allogeneic PBSC after RIC conditioning. Data from 1859 AML pts in first (n=1439) or second (n=420) CR transplanted between 2000 and 2009 following a RIC regimen at EBMT affiliated centres were analyzed. Pts were given PBSC from HLA-identical sibling (MRD, n=1208), or from HLA-matched unrelated donors (MUD, n=651). Median pt age at transplantation was 56 y (range, 18–77). 338 male pts were given grafts from female donors. RIC was based on low-dose TBI in 520 (28%) pts, while the remaining pts received chemotherapy-based RIC. ATG was given in 269 (22%) MRD and in 267 (41%) MUD recipients, respectively, while 151 (13%) MRD and 165 (25%) MUD recipients received in-vivo T cell depletion with alemtuzumab. The impact of chronic GVHD on relapse risk, non-relapse mortality (NRM), leukemia-free survival (LFS), and overall survival (OS) was assessed using time-dependent multivariate Cox models and in a landmark analysis at 18 months after transplant. Three-year incidences of relapse, NRM, LFS and OS were 34±1%, 15±1%, 51±2% and 60±2% in MRD recipients, respectively, and 34±2% (p=NS), 24±2% (P<0.001), 42±2% (P=0.001) and 47±2% (P=0.001) in MUD recipients, respectively. Grade II, III and IV acute GVHD were observed in 133 (11%), 61 (5%) and 30 (2%) MRD recipients and in 119 (18%), 41 (6%) and 24 (4%) MUD recipients, respectively. The 3-y cumulative incidence of chronic GVHD was 47%. Fifty-three percent of patients with chronic GVHD had extensive chronic GVHD, while the remaining 47% had limited chronic GVHD. In multivariate analyses, occurrence of grade II-IV acute GVHD was associated with a lower risk of relapse (HR=0.8; P=0.04), a higher risk of chronic (HR=2.2; P<0.001) and extensive chronic GVHD (HR=2.8; P<0.001), a higher risk of NRM (HR=2.4 P<0.001), a worsened LFS (HR=1.3; P=0.01), and a worsened OS (HR=1.5; P<0.001). In multivariate time-dependent analyses, occurrence of limited chronic GVHD was associated with a lower risk of relapse (HR=0.7; P=0.05), comparable NRM (HR=1.4; P=0.16), comparable LFS (HR=0.9; P=0.29) and better OS (HR=0.5; P<0.001), while occurrence of extensive chronic GVHD was associated with a lower risk of relapse (HR=0.6; P=0.01), higher NRM (HR=3.2; P<0.001), a trend for worsened LFS (HR=1.3; P=0.06) and comparable OS (HR=0.9; P=0.34). The median interval from transplantation to occurrence of chronic GVHD was 163 (range, 100–1545) days. To further assess the graft-versus-leukemia effect of chronic GVHD, we performed a landmark analysis in patients who were leukemia-free at 18 months after transplantation (n=776). Median follow-up from this landmark time-point was 24 (range, 0.1–112) months. Two-year relapse, NRM, LFS and OS were 16±2%, 2.5±1%, 82±2%, and 89±2%, respectively, in patients without chronic GVHD before the landmark time-point, versus 9±1% (P=0.001), 8±1% (P<0.001), 83±2% (P=0.65), and 86±2% (P=0.38), respectively, in patients with chronic GVHD before the landmark time-point.In conclusion, in this cohort of AML patients transplanted in remission, occurrence of chronic GVHD was associated with a lower risk of relapse that translated to better OS in patients with limited chronic GVHD but not in those with extensive chronic GVHD who experienced higher long term NRM, highlighting the need for long term prospective assessment of long term effects and quality of life in patients receiving RIC allo-SCT. [less ▲]

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See detailProspective Person Memory and Retrospective Person Memory for Age Progressed Images
Lampinen, James Michael; Dehon, Hedwige ULg; Miller, Justin T.

Poster (2011)

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See detailActors' benefit analysis on value chain of fresh dairy milk in Vietnam
Tran Huu; Bui, Thi Nga ULg

in Journal of Economics & Development (2011), (169(II)), 32-38

Vietnam locates in the Asia-the most active region, where gains the highest economic growth rate and highest milk consumption in the world. Vietnam also ranks the second among the highest milk ... [more ▼]

Vietnam locates in the Asia-the most active region, where gains the highest economic growth rate and highest milk consumption in the world. Vietnam also ranks the second among the highest milk productivity in the Asia and milk consumption is increasing rapidly. However, the dairy industry in Vietnam is currently able to meet only 22% of domestic demand; the remaining amount has been imported (VOV/VNA, 2008). In addition, raw milk price is very low while retail price is too high. It leads to low effective in the production of the whole chain. This paper is based on the value chain approach within both quantitative and qualitative methods to evaluate a typical fresh value chain in the North of Vietnam in (Moc Chau platation) in 2008 - 2010. The findings show that the dairy plant is the most powerful actor in the chain and it drives the whole chain while power of dairymen is very weak. The value added of the chain is distributed unequally among its actors in whom more benefitable for non-dairy cow producers. In particular, the value added in dairy cow stage would be much lower. [less ▲]

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See detailThe Herschel view of nebulae around evolved massive stars
Vamvatira-Nakou, Chloi ULg; Royer, P.; Hutsemekers, Damien ULg et al

Conference (2011)

The detailed study of the nebulae ejected from Luminous Blue Variables and the circumstellar bubbles around Wolf-Rayet stars, which radiate strongly in the IR due to the heating of dust, is crucial for ... [more ▼]

The detailed study of the nebulae ejected from Luminous Blue Variables and the circumstellar bubbles around Wolf-Rayet stars, which radiate strongly in the IR due to the heating of dust, is crucial for understanding the massive stars evolution. With Herschel, the largest telescope ever flown in space, we are able to study the gas and the dust in these circumstellar environments in the full far-infrared waveband. In the context of 'Mass-loss of Evolved StarS' Herschel guaranteed time key programme, we have obtained imaging and spectroscopic observations of nebulae associated with Luminous Blue Variable and Wolf-Rayet stars using PACS, one of the three instruments onboard Herschel. A description of these observations and first results of the data analysis are presented. [less ▲]

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See detailEtude de l'activité antifongique des bactéries lactiques isolées de produits alimentaires fermentés et caractérisation de leurs métabolites inhibiteurs
Ndagano, Dora ULg

Doctoral thesis (2011)

Summary: The aim of this present research was to study the antifungal properties of lactic acid bacteria (LAB) isolated from fermented Mill flour and fermented cassava in order to use them for ... [more ▼]

Summary: The aim of this present research was to study the antifungal properties of lactic acid bacteria (LAB) isolated from fermented Mill flour and fermented cassava in order to use them for biopreservation. Antifungal activity of these LAB were assessed in MRS solid medium against food spoilage moulds as Aspergillus niger MUCL 28699, Aspergillus niger CWBIF194, Aspergillus tubingensis MP1 and Penicillium crustosum MY1. Three strains, Lactobacillus plantarum VE56, Weissella cibaria FMF4B16 and Weissella paramesenteroides LC11 were selected among 116 for their strongest inhibitory activity and their broad inhibitory spectrum against food moulds. The 4-fold concentrated supernatant of L. plantarum VE56 and W. paramesenteroides LC11 had the strongest inhibitory activity to compare to W. cibaria FMF4B16. The antifungal activity of the cell-free supernatant was pH dependent and insensitive to proteolytic enzymes action suggesting that the inhibitory activity was due to other compounds than proteins. The identification of antifungal compounds by chromatographic studies highlighted the production of phenyllactic acid by the three strains. In addition, 2-hydroxy-3-methylpentanoic acid and 2-hydroxy-4-methylpentanoic acid were produced by L. plantarum VE56 and W. paramesenteroides LC11. However, the concentration assessed in the supernatant was lower than the minimal inhibitory concentration showing a synergic action of all these produced compounds. The effect of the antifungal supernatant of L. plantarum VE56 and W. paramesenteroides LC11 on Aspergillus flavus NRRL 3357 resulted to an inhibition of conidial development and aflatoxin B1 production which was reflected in decreased gene expression of brlA (conidiophore specific transcription factor) and laeA (global regulator of secondary metabolism). These two bacteria also delayed Penicillium expansum MUCL 14498 conidial development in bread. [less ▲]

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See detailDigressions politiques autour de la technique du passe-muraille
Brausch, Géraldine ULg

in Libert, Cédric (Ed.) Espèces d’architecte. Wallonie-Bruxelles (2011)

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See detailNonlinear Normal Modes of a Full-Scale Aircraft
Peeters, Maxime ULg; Kerschen, Gaëtan ULg; Golinval, Jean-Claude ULg et al

in 29th International Modal Analysis Conference, Jacksonville, 2011 (2011)

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See detailBespreking HvJ 18 maart 2010
Peeters, Bart ULg

in Rechtskundig Weekblad (2011)

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See detailTraumatologie du golf
Kaux, Jean-François ULg; Crielaard, Jean-Michel ULg

Learning material (2011)

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See detailLa main de Gilliatt-Sumner ou le syndrome de défilé cervicothoracique neurogène vrai. A propos de sept cas opérés.
DUBUISSON, Annie ULg; NGUYEN KHAC, Minh-Tuan ULg; SCHOLTES, Félix ULg et al

in Neuro-Chirurgie (2011), 57(1), 9-14

BACKGROUND AND PURPOSE: The clinical picture of hand atrophy related to a cervical rib or elongated C7 transverse process was well described in the modern literature by Gilliatt and Sumner; in 1970, they ... [more ▼]

BACKGROUND AND PURPOSE: The clinical picture of hand atrophy related to a cervical rib or elongated C7 transverse process was well described in the modern literature by Gilliatt and Sumner; in 1970, they reported a series of nine patients whose motor status was stabilized following brachial plexus decompression. We report here seven patients suffering from thoracic outlet syndrome (TOS), who developed hand atrophy, sometimes because of diagnostic delay. METHODS: The patient's charts were analysed retrospectively. RESULTS: The seven patients were all female; the mean age was 43 years. The first complaints were arm pain and paresthesias lasting six months to 5 years. Three patients were treated with C56/C67 discectomy plus disc prosthesis (one patient), ulnar neurolysis at the elbow (the same patient), carpal tunnel release (one patient), and intravenous immunoglobulins (one patient) before TOS diagnosis. Hand atrophy, severe in five patients, was present at presentation. All patients underwent brachial plexus decompression by the anterior (four), posterior (two), or transaxillary (one) approach. This last approach was completed 18 months later by brachial plexus neurolysis via the anterior approach. Postoperatively, motor deficit was improved in two patients and stabilized in five patients. CONCLUSIONS: Physicians' unfamiliarity with TOS diagnosis or their reluctance to accept the diagnosis without electrical confirmation can lead to hand atrophy. Brachial plexus decompression at this stage usually stabilizes the deficit. [less ▲]

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See detailElectrophysiologic recurrent laryngeal nerve monitoring during thyroid and parathyroid surgery:international standards guideline statement
Randolph, Gregory; Dralle, Henning; Abdullah, hisham et al

in Laryngoscope (2011), 121

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See detailLes animaux ont-ils des droits subjectifs ? - Les droits des animaux
Delnoy, Michel ULg

in Revue de la Faculté de Droit de l'Université de Liège (2011), 2

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See detailSource parameters of the 2008 Bukavu-Cyangugu earthquake estimated from InSAR and teleseismic data
d'Oreye, Nicolas; Gonzalez, P.; Shuler, A. et al

in Geophysical Journal International (2011)

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See detailReseña de Ficciones barrocas, de Carlos Gamerro
Willson, Patricia ULg

in Iberoamericana (2011), 11(44), 211-214

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See detailExplaining Returns on Venture Capital-Backed Companies: Evidence from Belgium
Alperovych, Yan ULg; Hübner, Georges ULg

in Research in International Business and Finance (2011), 25(3), 277-295

Using a unique database of 990 VC-backed Belgian firms, we study whether compatibility between corporate and environmental characteristics matters. We address two questions: (i) Does the interplay of ... [more ▼]

Using a unique database of 990 VC-backed Belgian firms, we study whether compatibility between corporate and environmental characteristics matters. We address two questions: (i) Does the interplay of company, industry, and product factors affect the expected returns of the VC-backed firms? (ii) Does the joint compatibility between these factors results in a non-linear increase in performance? Panel data analysis shows a significant influence of factor compatibility on returns. Quantile regression analysis indicates a non-linear relationship between the return and its determinants. Conjoint analysis identifies certain combinations of factors, which collapse into classifiable patterns described in the strategic management literature. [less ▲]

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See detailDeforestation in Central and West Africa: landscape dynamics, anthropogenic effects and ecological consequences.
Barima, Y S S; Djibu, J P; Alongo, S et al

in Daniels, J A (Ed.) Advances in Environmental Research - Volume 7 (2011)

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See detailBRYOPHYTES DU PARC NATIONAL DU MERCANTOUR : METHODES ET RESULTATS DE LA CAMPAGNE D'INVENTAIRES 2010 ATBI+M
Saatkamp, Arne; Aleffi, Michele; de Biaggi, Marta et al

in Biocosme Mesogeen (2011), 28(2), 23-50

During the All Taxa Biodiversity Inventory + Monitoring programme (ATBI+M) in the Mercantour and Alpi Marittime National Parks, our inventories of bryophytes identified 234 taxa (mosses and liverworts ... [more ▼]

During the All Taxa Biodiversity Inventory + Monitoring programme (ATBI+M) in the Mercantour and Alpi Marittime National Parks, our inventories of bryophytes identified 234 taxa (mosses and liverworts). This work completes the previous field campaigns, notably those of Jean-Pierre Hebrard (I MEP, Marseille) since 1965, and the ATBI bryophyte inventories in 2007. This number is based on four days of inventories in the central and peripheric territory of both National Parks, in four days in July and August 2010, together with previous data the 565 taxa known from the area still underestimate the number of species actually present. Our observations in 2010 added several new species for this area, including several rare and remarkable species such as Haplomitrium hookeri or species listed under the Habitats Directive as Buxbaumia viridis and Orthotrichum rogeri. Given the rarity of their habitats species from snow beds, large block boulders and high altitude wetlands are most remarkable. [less ▲]

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See detailTropical forest carbon stocks estimates. Is tree aboveground biomass variability at the landscape scale really non-significant in a REDD+ context?
Bastin, Jean-François ULg; Bogaert, Jan ULg; De Cannière, C

in Research Priorities in Tropical Silviculture: Towards New Paradigms? (2011)

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See detailOnderneming en recht. Bedrijfsfiscaliteit
Peeters, Bart ULg

Book published by Knops Publishing (2011)

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