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See detailPotential Therapeutic Target Discovery by 2D-DIGE Proteomic Analysis in Mouse Models of Asthma
QUESADA CALVO, Florence ULiege; Fillet, Marianne ULiege; Renaut, Jenny et al

in Journal of Proteome Research (2011), 10(9), 4291-4301

As asthma physiopathology is complex and not fully understood to date; it is expected that new key mediators are still to be unveiled in this disease. The main objective of this study was to discover ... [more ▼]

As asthma physiopathology is complex and not fully understood to date; it is expected that new key mediators are still to be unveiled in this disease. The main objective of this study was to discover potential new target proteins with a molecular weight >20 kDa by using two-dimensional differential in-gel electrophoresis (2D-DIGE) on lung parenchyma extracts from control or allergen-exposed mice (ovalbumin). Two different mouse models leading to the development of acute airway inflammation (5 days allergen exposure) and airway remodeling (10 weeks allergen exposure) were used. This experimental setting allowed the discrimination of 33 protein spots in the acute inflammation model and 31 spots in the remodeling model displaying a differential expression. Several proteins were then identified by MALDI-TOF/TOF MS. Among those differentially expressed proteins, PDIA6, GRP78, Annexin A6, hnRPA3, and Enolase display an increased expression in lung parenchyma from mice exposed to allergen for 5 days. Conversely, Apolipoprotein A1 was shown to be decreased after allergen exposure in the same model. Analysis on lung parenchyma of mice exposed to allergens for 10 weeks showed decreased calreticulin levels. Changes in the levels of those different mediators were confirmed by Western blot and immunohistochemical analysis. Interestingly, alveolar macrophages isolated from lungs in the acute inflammation model displayed enhanced levels of GRP78. Moreover, intratracheal instillation of anti-GRP78 siRNA in allergen-exposed animals led to a decrease in eosinophilic inflammation and bronchial hyperresponsiveness. This study unveils new mediators of potential importance that are up- and down-regulated in asthma. Among up-regulated mediators, GRP-78 appears as a potential new therapeutic target worthy of further investigations. [less ▲]

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See detailRadionécrose historique
CAUCANAS, Marie ULiege; PIERARD-FRANCHIMONT, Claudine ULiege; QUATRESOOZ, Pascale ULiege et al

in Revue Médicale de Liège (2011), 66

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See detailConsidering Laminated Cores and Eddy Currents in 2D and 3D Finite Element Simulation of Electrical Machines
Gyselinck, Johan; Geuzaine, Christophe ULiege; V Sabariego, Ruth ULiege

(2011)

This paper deals with a time-domain homogeniza- tion method for laminated cores and its application to the 2D finite element simulation of rotating electrical machines. The number of additional degrees of ... [more ▼]

This paper deals with a time-domain homogeniza- tion method for laminated cores and its application to the 2D finite element simulation of rotating electrical machines. The number of additional degrees of freedom of the model, for considering the variation of the flux density along the lamination thickness, can be tuned so as to reach a good compromise between accuracy and computation time. The results obtained for a switched reluctance motor agree very well with those produced by a precise full 3D model in which eddy currents are explicitly modeled. [less ▲]

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See detailSedimentology of a continuous Givetian-Frasnian carbonate succession in Sauerland (Germany) and MS comparison with the time-equivalent ones of Ardennes (Belgium) and Moravia (Czech Republic).
Pas, Damien ULiege; Da Silva, Anne-Christine ULiege; Boulvain, Frédéric ULiege et al

in Suttner, Thomas; Kido, Erika; Piller, W. E. (Eds.) et al IGCP-596 Mid-Paleozoic climate and biodiversity, 19-24 septembre, Graz, Austria, Abstract book (2011)

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See detailA finite element analysis of the bending and the bendability of metallic sheets
Ben Bettaieb, Mohamed ULiege; Lemoine, Xavier; Bouaziz, O. et al

in International Journal of Material Forming (2011), 4(3), 283-297

The main objective of this paper is to study the bendability of metallic sheets by using the finite element method. In this aim, two variants of an advanced Gurson-Tvergaard-Needleman model [1, 2] are ... [more ▼]

The main objective of this paper is to study the bendability of metallic sheets by using the finite element method. In this aim, two variants of an advanced Gurson-Tvergaard-Needleman model [1, 2] are implemented in the home made FE code LAGAMINE [3, 4] and coupled with the Thomason model to predict the coalescence of voids. This advanced model is an extension of the original one to take into account of the plastic anisotropy and the mixed (isotropic + kinematic) hardening of the matrix. The difference between the two variants is related to the modeling of the damage evolution. As the advanced model is used to study the bending process, its yield function is slightly modified in order to take into account the loadings with negative triaxiality ratios. These present implementations are used to simulate the pure bending process and to predict the bendability of dual phase (DP) steel. The combined effect of an initial geometrical imperfection and damage evolution on the bendability is also studied. [less ▲]

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See detailEn guise de conclusion : chronologie, technologies et faciès culturels du Gravettien français
Noiret, Pierre ULiege

in Pesesse, Damien; Goutas, Nejma; Klaric, Laurent (Eds.) et al À la recherche des identités gravettiennes : actualités, questionnements et perspectives (2011)

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See detailFaut-il réformer l’orthographe ? Craintes et attentes des francophones
Lafontaine, Dominique ULiege

in Groupe RO (Ed.) Faut-il réformer l’orthographe ? Craintes et attentes des francophones (2011)

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See detailFlaxseed proteins: food uses and health benefits flaxseed proteins
Rabetafika, Holy-Nadia ULiege; Van Remoortel, Vinciane ULiege; Danthine, Sabine ULiege et al

in International Journal of Food Science & Technology (2011), 46(2), 221-228

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See detailPresbyastasie et application de la réhabilitation vestibulaire en gériatrie
Costa de Araujo, Pedro ULiege; DEMANEZ, Laurent CH P ULiege; Lechien, Jerôme et al

in Revue Médicale de Liège (2011), 66(3), 130-4

Balance disorders can have a major functional impact among the elderly. The main risk is falling. Three elements are implicated in the loss of balance: vision, proprioception and the vestibular system ... [more ▼]

Balance disorders can have a major functional impact among the elderly. The main risk is falling. Three elements are implicated in the loss of balance: vision, proprioception and the vestibular system. This article will discuss mainly vestibular damage and its implications. The assessment of balance disorders, particularly in geriatric patients, is based on validated scales composed of several items. These provide scores and are based on the results of chronometric measurements. They can be useful for the application of Vestibular Rehabilitation (VR ), a technique improving the adaptation and autonomy of these patients. Vestibular rehabilitation is therefore part of an overall support, the goal of therapy being to improve daily life and to reduce the risk of falls. [less ▲]

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See detailTémoignage 2: les mathématiques dans le programme du cursus en sciences biologiques
Thiry, Marc ULiege

Diverse speeche and writing (2011)

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See detailManipulation of Droplets onto a Planar Interface
Gilet, Tristan ULiege; Terwagne, Denis ULiege; Vandewalle, Nicolas ULiege et al

in miller, reinhard; liggieri, libero (Eds.) Progress in Colloid and Interface Science, 2 (2011)

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See detailPopulation of nonnative States of lysozyme variants drives amyloid fibril formation.
Buell, Alexander K.; Dhulesia, Anne; Mossuto, Maria F. et al

in Journal of the American Chemical Society (2011), 133(20), 7737-43

The propensity of protein molecules to self-assemble into highly ordered, fibrillar aggregates lies at the heart of understanding many disorders ranging from Alzheimer's disease to systemic lysozyme ... [more ▼]

The propensity of protein molecules to self-assemble into highly ordered, fibrillar aggregates lies at the heart of understanding many disorders ranging from Alzheimer's disease to systemic lysozyme amyloidosis. In this paper we use highly accurate kinetic measurements of amyloid fibril growth in combination with spectroscopic tools to quantify the effect of modifications in solution conditions and in the amino acid sequence of human lysozyme on its propensity to form amyloid fibrils under acidic conditions. We elucidate and quantify the correlation between the rate of amyloid growth and the population of nonnative states, and we show that changes in amyloidogenicity are almost entirely due to alterations in the stability of the native state, while other regions of the global free-energy surface remain largely unmodified. These results provide insight into the complex dynamics of a macromolecule on a multidimensional energy landscape and point the way for a better understanding of amyloid diseases. [less ▲]

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See detailLearning a motor skill: Effects of blocked versus random practice. A review
Merbah, Sarah ULiege; Meulemans, Thierry ULiege

in Psychologica Belgica (2011), 51

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See detailComputation of induced fields into the human body by using dual formulations
Scorretti, Riccardo; V Sabariego, Ruth ULiege; Morel, L. et al

(2011)

In this work we present the use of two dual formulations to compute Extremely Low frequency (ELF) induced fields into the human body. This allows to estimate the numerical error, as well as rigorously ... [more ▼]

In this work we present the use of two dual formulations to compute Extremely Low frequency (ELF) induced fields into the human body. This allows to estimate the numerical error, as well as rigorously bound the (global) co-energy. This method is here applied to the classical case of the exposure to a homogeneous magnetic field. [less ▲]

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