References of "2011"
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See detailDeterminants of high, median and low rates of caesarean deliveries in Belgium
Absil, Gaëtan ULg; Van Parys, A. S.; Bednarek, Stéphanie et al

Report (2011)

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See detailLaurent (Brice), Les politiques des nanotechnologies. Pour un traitement démocratique d’une science émergente
Thoreau, François ULg

in Politix : Revue des Sciences Sociales du Politique (2011), 2011/4(96), 187-190

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See detailMastectomie bilaterale prophylactique chez les patientes a tres haut risque de cancer mammaire: au-dela de la technique...
BLERET, Valerie ULg; Cusumano, P.; DEZFOULIAN, Bahram ULg et al

in Revue Médicale de Liège (2011), 66(5-6), 250-3

Bilateral prophylactic mastectomy is the most efficient risk management strategy for women at very high risk for breast cancer. Different methods can be used. The implementation of such a strategy must ... [more ▼]

Bilateral prophylactic mastectomy is the most efficient risk management strategy for women at very high risk for breast cancer. Different methods can be used. The implementation of such a strategy must respond to the request of a well informed patient. [less ▲]

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See detailRelationship between bone mineral density changes and risk of fractures among patients receiving calcium with or without vitamin D supplementation: a meta-regression
Rabenda, Véronique ULg; Bruyère, Olivier ULg; Reginster, Jean-Yves ULg

in Osteoporosis International (2011), 22

Surrogate measures of fracture risk, such as effects on bone mineral density, may be of great interest to assess the efficacy of available osteoporosis treatments. Our results suggest that bone mineral ... [more ▼]

Surrogate measures of fracture risk, such as effects on bone mineral density, may be of great interest to assess the efficacy of available osteoporosis treatments. Our results suggest that bone mineral density (BMD) changes cannot be used as a surrogate of anti-fracture efficacy, among patients receiving calcium, with or without vitamin D. Introduction: The purpose of this study is to examine the association between changes in bone mineral density with reduction in the risk of fractures in patients receiving calcium with or without vitamin D. Methods: We selected all randomized placebo-controlled clinical trials of calcium with or without vitamin D supplementation. To be included in this analysis, the studies were required to report both BMD (hip/proximal femur and/or lumbar spine) and the incidence of fractures. Metaregression analyses were used to examine the associations of changes in BMD with reduction in risk of fracture over the duration of each study. The change in BMD was the difference between changes (from baseline) observed in the active treatment group and placebo group. Results: A total of 15 randomized trials (n=47,365) were identified, most of whom (77%) came from the Women’s Health Initiative trial. Results show that larger increases in BMD at the lumbar spine were not associated with greater reduction in fracture risk. Concerning hip BMD changes, we found a statistically significant relationship between hip BMD changes and reduction in risk. However, results were not quite significant after excluding the both largest studies, in which BMD changes were measured in very small subset of patients. These points may have largely biased our results. Conclusions: In conclusion, there was no evidence of a relationship between BMD changes and reduction in risk of fractures among patients receiving calcium with or without vitamin D supplementation. Calcium and/or Vitamin D may reduce fracture rates through a mechanism independent of bone density. [less ▲]

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See detailOptimal management of migraine taking into account comorbidities and “positive side effects”
Sándor, C; Dodick, DW; Schoenen, Jean ULg

in Schoenen, Jean; Dodick, DW; Sándor, C (Eds.) Comorbidity in Migraine (2011)

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See detailL'imperatrice. Le Molte Vite di Indira Gandhi
Maiorano, Diego ULg

in Storia della Storiografia (2011), 58

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See detailOptimal design of multi-subject blocked fMRI experiments.
Maus, Bärbel ULg; van Breukelen, Gerard J P; Goebel, Rainer et al

in NeuroImage (2011), 56(3), 1338-1352

The design of a multi-subject fMRI experiment needs specification of the number of subjects and scanning time per subject. For example, for a blocked design with conditions A or B, fixed block length and ... [more ▼]

The design of a multi-subject fMRI experiment needs specification of the number of subjects and scanning time per subject. For example, for a blocked design with conditions A or B, fixed block length and block order ABN, where N denotes a null block, the optimal number of cycles of ABN and the optimal number of subjects have to be determined. This paper presents a method to determine the optimal number of subjects and optimal number of cycles for a blocked design based on the A-optimality criterion and a linear cost function by which the number of cycles and the number of subjects are restricted. Estimation of individual stimulus effects and estimation of contrasts between stimulus effects are both considered. The mixed-effects model is applied and analytical results for the A-optimal number of subjects and A-optimal number of cycles are obtained under the assumption of uncorrelated errors. For correlated errors with a first-order autoregressive (AR1) error structure, numerical results are presented. Our results show how the optimal number of cycles and subjects depend on the within- to between-subject variance ratio. Our method is a new approach to determine the optimal scanning time and optimal number of subjects for a multi-subject fMRI experiment. In contrast to previous results based on power analyses, the optimal number of cycles and subjects can be described analytically and costs are considered. [less ▲]

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See detailNegations at Medinet Habu
Gillen, Todd Jonathan ULg

Conference (2011)

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See detailBrain natriuretic peptide in asymptomatic degenerative mitral regurgitation: determinants and impact on outcome.
Van de Heyning, C; Magne, Julien ULg; Mahjoub, H et al

Conference (2011)

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See detailPotential of near infrared spectroscopy for on-line analysis at the milking parlour using a fiber-optic probe presentation
Nguyen, Hoang Nam; Dehareng, Frédéric; Hammida, Mohamed et al

in NIR news (2011), 22

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See detailA discrete competitive facility location model with variable attractiveness
Kucukaydin, Hande ULg; Aras, Necati; Altinel, I. Kuban

in Journal of the Operational Research Society (2011), 62(9), 1726-1741

We consider the discrete version of the competitive facility location problem in which new facilities have to be located by a new market entrant firm to compete against already existing facilities that ... [more ▼]

We consider the discrete version of the competitive facility location problem in which new facilities have to be located by a new market entrant firm to compete against already existing facilities that may belong to one or more competitors. The demand is assumed to be aggregated at certain points in the plane and the new facilities can be located at predetermined candidate sites. We employ Huff’s gravity-based rule in modelling the behaviour of the customers where the probability that customers at a demand point patronize a certain facility is proportional to the facility attractiveness and inversely proportional to the distance between the facility site and demand point. The objective of the firm is to determine the locations of the new facilities and their attractiveness levels so as to maximize the profit, which is calculated as the revenue from the customers less the fixed cost of opening the facilities and variable cost of setting their attractiveness levels. We formulate a mixed-integer nonlinear programming model for this problem and propose three methods for its solution: a Lagrangean heuristic, a branch-and-bound method with Lagrangean relaxation, and another branch-and-bound method with nonlinear programming relaxation. Computational results obtained on a set of randomly generated instances show that the last method outperforms the others in terms of accuracy and efficiency and can provide an optimal solution in a reasonable amount of time. [less ▲]

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See detailUrinary NGAL measurement : Biological variation and ratio to creatinine
Delanaye, Pierre ULg; Rozet, Eric ULg; Krzesinski, Jean-Marie ULg et al

in Clinica Chimica Acta (2011), 412(3-4), 390

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See detailIntérêt d'une augmentation de dose des analogues de la somatostatine dans l'acromégalie
Vasilev, Vladimir; Beckers, Albert ULg

in Andrologic (2011), 7(4),

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See detailCurrent options for the management of postmenopausal osteoporosis.
LECART, Marie-Paule ULg; Reginster, Jean-Yves ULg

in Expert Opinion on Pharmacotherapy (2011), 12(16), 2533-52

INTRODUCTION: Osteoporosis is a well-recognized disease with severe consequences if left untreated. The prevention of osteoporosis-associated fractures should include fall prevention, calcium ... [more ▼]

INTRODUCTION: Osteoporosis is a well-recognized disease with severe consequences if left untreated. The prevention of osteoporosis-associated fractures should include fall prevention, calcium supplementation and life-style advice, as well as pharmacological therapy using agents with proven antifracture efficacy. AREAS COVERED: This manuscript offers an evidence-based critical assessment of the currently available efficacy data on all new chemical entities that have been granted a marketing authorization for the management of primary osteoporosis in women. EXPERT OPINION: The availability of new therapeutic agents makes clinical decision making in osteoporosis more complex. Therapeutic decisions should be based on a balance between the benefits and risks of treatment, which must be carefully considered in each particular case, both by the physician and the patient. Indeed, no single agent is appropriate for all patients. Therefore, treatment decisions should be made on a tailor-made basis, taking into account all measures of treatment effect and risk, before making informed judgments about the best individual treatment option. [less ▲]

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See detailThe extension of the INCL model for simulation of shielding in space
Pedoux, Sophie ULg; Cugnon, Joseph ULg; Mancusi, Davide ULg et al

in Advances in Space Research (2011), 48(2), 383-389

Radiation hazard for space missions is mainly due to cosmic ray protons, helium nuclei and light ions, whose energy spectrum is maximum around 1 GeV per nucleon but remains non-negligible for energies up ... [more ▼]

Radiation hazard for space missions is mainly due to cosmic ray protons, helium nuclei and light ions, whose energy spectrum is maximum around 1 GeV per nucleon but remains non-negligible for energies up to 15 GeV per nucleon. Nuclear reactions induced by high energy protons are often described by intranuclear cascade plus evaporation models. The attention is focused here on the Liège Intranuclear Cascade model (INCL), which has been shown to reproduce fairly well a great deal of experimental data for nucleon-induced reactions in the 200 MeV to 2 GeV range, when coupled with the ABLA evaporation-fission code. In order to extend the model to other conditions relevant for space radiation, three improvements of INCL are under development. They are reported on here. First, the reaction model has been extended to nucleon-nucleus reactions at incident energies up to 15 GeV, mainly by the inclusion of additional pion production channels in nucleon-nucleon collisions during the cascade. Second, a coalescence mechanism for the emission of light charged particles has been implemented recently. Finally, the model has been modified in order to accommodate light ions as projectiles. First results are shown and compared with illustrative experimental data. Implications for issues concerning radiation protection in space are discussed. [less ▲]

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