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See detailUnderstanding Crystallization of Anatase into Binary SiO2/TiO2 Sol-Gel Optical Thin Films: An in Situ Thermal Ellipsometry Analysis
Louis, B.; Krins, Natacha ULg; Faustini, M. et al

in Journal of Physical Chemistry C: Nanomaterials, Interfaces, and Hard Matter (2011), 115

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See detailHydrogeological study of Somes-Szamos transboundary alluvial aquifer
Drobot, Radu; Szucs, Peter; Brouyère, Serge ULg et al

in Ganoulis, Jacques; Aureli, Alice; Fried, Jean (Eds.) Transboundary Water Resources Management: A Multidisciplinary Approach (2011)

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See detailTrabectedine (ET-743/Yondelis) dans le traitement des sarcomes des tissus mous et du cancer de l'ovaire.
GENNIGENS, Christine ULg; Jerusalem, Guy ULg

in Revue Médicale de Liège (2011), 66(7-8), 452-5

Soft tissue sarcomas account for 1% of all malignant tumours. Until a few years ago, doxorubicine and ifosfamide were the only active chemotherapy drugs in the metastatic setting. Recently, a new drug has ... [more ▼]

Soft tissue sarcomas account for 1% of all malignant tumours. Until a few years ago, doxorubicine and ifosfamide were the only active chemotherapy drugs in the metastatic setting. Recently, a new drug has proven its efficacy after failure of standard treatments: the trabectedin; its activity is based on interference with ADN repair mechanisms. Trabectedin has just been also validated and reimbursed in patients with ovarian cancer, in partially sensitive recurrence. In this paper, we will review the mechanism of action and the clinical results of trabectedin. [less ▲]

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See detailPour une épistémologie des Lettres
Badir, Sémir ULg

in Fabula LHT (2011), 8

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See detailMicro-CT-based improvement of geometrical and mechanical controllability of selective laser melted Ti6Al4V porous structures
Van Bael, S.; Kerckhofs, Greet ULg; Moesen, M. et al

in MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING (2011), 528(24), 7423-7431

Despite the fact that additive manufacturing (AM) techniques allow to manufacture complex porous parts with a controlled architecture, differences can occur between designed and as-produced morphological ... [more ▼]

Despite the fact that additive manufacturing (AM) techniques allow to manufacture complex porous parts with a controlled architecture, differences can occur between designed and as-produced morphological properties. Therefore this study aimed at optimizing the robustness and controllability of the production of porous Ti6Al4V structures using selective laser melting (SLM) by reducing the mismatch between designed and as-produced morphological and mechanical properties in two runs. In the first run, porous Ti6Al4V structures with different pore sizes were designed, manufactured by SLM, analyzed by microfocus X-ray computed tomography (micro-CT) image analysis and compared to the original design. The comparison was based on the following morphological parameters: pore size, strut thickness, porosity, surface area and structure volume. Integration of the mismatch between designed and measured properties into a second run enabled a decrease of the mismatch. For example, for the average pore size the mismatch decreased from 45% to 5%. The demonstrated protocol is furthermore applicable to other 3D structures, properties and production techniques, powder metallurgy, titanium alloys, porous materials, mechanical characterization, tomography. (C) 2011 Elsevier B.V. All rights reserved. [less ▲]

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See detailLa famille transnationale dans tous ses états
Razy, Elodie ULg; Baby-Collin, Virginie

in Autrepart : Revue de Sciences Sociales au Sud (2011), 57-58

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See detailLa contradiction des motifs : réflexions à partir du droit belge
Henry, Frédéric ULg; Caprasse, Olivier ULg

in Revue de l'Arbitrage (2011)

La contradiction des motifs d'une sentence arbitrale ne devrait pas être assimilée à l'absence de ses motifs et ne pas conduire à l'annulation de la sentence

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See detailLes terres cuites architecturales des églises du haut Moyen Age du NW de la France et du SE de l’Angleterre. Application de la datation par luminescence à l’archéologie du bâti
Blain, Sophie ULg

Book published by Archaeopress (2011)

Until the 1960s, early medieval religious architecture suffered from a general lack of interest by the field of archaeology resulting in a real need for the improvement in knowledge of this often ... [more ▼]

Until the 1960s, early medieval religious architecture suffered from a general lack of interest by the field of archaeology resulting in a real need for the improvement in knowledge of this often-misinterpreted art. Initially considered as outmoded or backward, early medieval architecture is actually dynamic, particularly the transition period between the 9th and the 11th centuries marked by its themes of transference and novelty. One of the features of this architecture is the use of ceramic building materials in the masonry, a technique from the Antiquity that can be observed continuing into the 11th and 12th centuries. This architectural characteristic is visible in areas touched by Roman traditions and particularly in north-western France and south-eastern England, which also benefit from a substantial concentration of early medieval buildings. One of the aims of this work is, therefore, to identify similar architectural tendencies and examine the technological choices made in the construction of the buildings under analysis. In order to achieve this, it is necessary to accurately position key-buildings in the architectural chronology. Amongst methods for this, luminescence dating applied to ceramic building materials is particularly attractive. Not only does it contribute to building archaeology through more precise dating, but its use in this specific aim also presents an opportunity to thoroughly test the method and essentially improve its potential. The first part of the study examines aspects of the political and religious contexts of the period between the 9th and the 11th century, as well as the associated architecture and its components. The second part is devoted to the presentation and the definition of the luminescence dating method. Bringing together these elements enables the twelve case studies from French and English sites selected for this chronology research work to be addressed in detail. Finally, a detailed study of the mode of use of ceramic building materials is presented and an interpretation of this architectural choice will be attempted. [less ▲]

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See detailControl of hydrogen photoproduction by the proton gradient generated by cyclic electron flow in Chlamydomonas reinhardtii.
Tolleter, Dimitri; Ghysels, Bart ULg; Alric, Jean et al

in Plant Cell (2011), 23(7), 2619-30

Hydrogen photoproduction by eukaryotic microalgae results from a connection between the photosynthetic electron transport chain and a plastidial hydrogenase. Algal H(2) production is a transitory ... [more ▼]

Hydrogen photoproduction by eukaryotic microalgae results from a connection between the photosynthetic electron transport chain and a plastidial hydrogenase. Algal H(2) production is a transitory phenomenon under most natural conditions, often viewed as a safety valve protecting the photosynthetic electron transport chain from overreduction. From the colony screening of an insertion mutant library of the unicellular green alga Chlamydomonas reinhardtii based on the analysis of dark-light chlorophyll fluorescence transients, we isolated a mutant impaired in cyclic electron flow around photosystem I (CEF) due to a defect in the Proton Gradient Regulation Like1 (PGRL1) protein. Under aerobiosis, nonphotochemical quenching of fluorescence (NPQ) is strongly decreased in pgrl1. Under anaerobiosis, H(2) photoproduction is strongly enhanced in the pgrl1 mutant, both during short-term and long-term measurements (in conditions of sulfur deprivation). Based on the light dependence of NPQ and hydrogen production, as well as on the enhanced hydrogen production observed in the wild-type strain in the presence of the uncoupling agent carbonyl cyanide p-trifluoromethoxyphenylhydrazone, we conclude that the proton gradient generated by CEF provokes a strong inhibition of electron supply to the hydrogenase in the wild-type strain, which is released in the pgrl1 mutant. Regulation of the trans-thylakoidal proton gradient by monitoring pgrl1 expression opens new perspectives toward reprogramming the cellular metabolism of microalgae for enhanced H(2) production. [less ▲]

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See detailValdeblore (06) Le Clouté
Pagès, Gaspard ULg

in D.R.A.C., S.R.A. (Ed.) Bilan scientifique de la région Provence-Alpes-Côte d’Azur 2010 (2011)

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See detailOrganisation du territoire de la cité antique de Narbonne : contraintes environnementales et exploitations des ressources
Cavero, Caroline; Sanchez, Corinne; Jézégou, Marie-Pierre et al

in Cavero, Caroline; Sanchez, Corinne; Jézégou, Maries-Pierre (Eds.) et al Fréjus romaine, la ville et son territoire : agglomérations de Narbonnaise, des Alpes-Maritimes et de Cisalpine à travers la recherche archéologique : actes du 8e Colloque historique de Fréjus, 8-10 octobre 2010 (2011)

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See detailSupraorbital transcutaneous neurostimulation has sedative effects in healthy subjects.
Piquet, Maxime; Balestra, Costantino; SAVA, Simona Liliana ULg et al

in BMC Neurology (2011), 11

BACKGROUND: Transcutaneous neurostimulation (TNS) at extracephalic sites is a well known treatment of pain. Thanks to recent technical progress, the Cefaly(R) device now also allows supraorbital TNS ... [more ▼]

BACKGROUND: Transcutaneous neurostimulation (TNS) at extracephalic sites is a well known treatment of pain. Thanks to recent technical progress, the Cefaly(R) device now also allows supraorbital TNS. During observational clinical studies, several patients reported decreased vigilance or even sleepiness during a session of supraorbital TNS. We decided therefore to explore in more detail the potential sedative effect of supraorbital TNS, using standardized psychophysical tests in healthy volunteers. METHODS: We performed a double-blind cross-over sham-controlled study on 30 healthy subjects. They underwent a series of 4 vigilance tests (Psychomotor Vigilance Task, Critical Flicker Fusion Frequency, Fatigue Visual Numeric Scale, d2 test). Each subject was tested under 4 different experimental conditions: without the neurostimulation device, with sham supraorbital TNS, with low frequency supraorbital TNS and with high frequency supraorbital TNS. RESULTS: As judged by the results of three tests (Psychomotor Vigilance Task, Critical Flicker Fusion Frequency, Fatigue Visual Numeric Scale) there was a statistically significant (p < 0.001) decrease in vigilance and attention during high frequency TNS, while there were no changes during the other experimental conditions. Similarly, performance on the d2 test was impaired during high frequency TNS, but this change was not statistically significant. CONCLUSION: Supraorbital high frequency TNS applied with the Cefaly(R) device decreases vigilance in healthy volunteers. Additional studies are needed to determine the duration of this effect, the underlying mechanisms and the possible relation with the stimulation parameters. Meanwhile, this effect opens interesting perspectives for the treatment of hyperarousal states and, possibly, insomnia. [less ▲]

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See detailOn Reflections and Reflexivity: Unpacking Research Dispositifs
Thoreau, François ULg

in Zülsdorf, Torben; Coenen, Christopher; Ferrari, Arianna (Eds.) et al Quantum Engagements: Social Reflections of Nanoscience and Emerging Technologies (2011)

Abstract. Science and Technology Studies (STS) scholars increasingly engage with science and technology (S&T) practitioners, scientists, engineers, and the like. The actual dynamics of these engagements ... [more ▼]

Abstract. Science and Technology Studies (STS) scholars increasingly engage with science and technology (S&T) practitioners, scientists, engineers, and the like. The actual dynamics of these engagements differ from one project, framework or school to the next. However, to be reflexive, such engagements need at some point to deal with the ambiguous relationship between ‘engager’ and ‘engaged’. In an attempt to disambiguate these interactive ties, this chapter takes inspiration from Vinciane Despret, a philosopher of science who has provided ethnographic studies of ethologists. It specifically draws on two of Despret’s arguments about experiments on animals, more precisely rats, and the paradoxical relationships to which they give rise. By means of analogy, it then illustrates the similar ways in which we, as STS scholars, might happen to frame our interactions with S&T practitioners. It argues that any experimental research dispositif necessarily implies a specific relationship dynamic with whoever is engaged. This should not be considered as an obstacle, but instead an opportunity for learning—yet only if the dispositif is open to protest. The analysis here took shape during an engagement study conducted at a large-scale R&D center in Flanders, Belgium. It is informed by ongoing involvement in a broader research project (STIR) that aims at fostering reflexivity among S&T practitioners. [less ▲]

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See detailField trip 3: Uppermost Devonian and Lower Carboniferous of Southern Belgium
Poty, Edouard ULg; Aretz, Markus; Denayer, Julien ULg

in Kölner Forum für Geologie und Paläontologie (2011), 20

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See detailExpression, purification of novel alkaline Staphylococcus xylosus lipase acting at high temperature
Bouaziz, Ahlem ULg; Habib, Horchani; Ben Salem, Nadia et al

in Biochemical Engineering Journal (2011), 54

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See detailESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS).
Reiner, Zeljko; Catapano, Alberico L; De Backer, Guy et al

in European Heart Journal (2011), 32(14), 1769-818

Cardiovascular disease (CVD) due to atherosclerosis of the arterial vessel wall and to thrombosis is the foremost cause of premature mortality and of disability-adjusted life years (DALYs) in Europe, and ... [more ▼]

Cardiovascular disease (CVD) due to atherosclerosis of the arterial vessel wall and to thrombosis is the foremost cause of premature mortality and of disability-adjusted life years (DALYs) in Europe, and is also increasingly common in developing countries.1 In the European Union, the economic cost of CVD represents annually E192 billion1 in direct and indirect healthcare costs. The main clinical entities are coronary artery disease (CAD), ischaemic stroke, and peripheral arterial disease (PAD). The causes of these CVDs are multifactorial. Some of these factors relate to lifestyles, such as tobacco smoking, lack of physical activity, and dietary habits, and are thus modifiable. Other risk factors are also modifiable, such as elevated blood pressure, type 2 diabetes, and dyslipidaemias, or non-modifiable, such as age and male gender. These guidelines deal with the management of dyslipidaemias as an essential and integral part of CVD prevention. Prevention and treatment of dyslipidaemias should always be considered within the broader framework of CVD prevention, which is addressed in guidelines of the Joint European Societies' Task forces on CVD prevention in clinical practice.2 - 5 The latest version of these guidelines was published in 20075; an update will become available in 2012. These Joint ESC/European Atherosclerosis Society (EAS) guidelines on the management of dyslipidaemias are complementary to the guidelines on CVD prevention in clinical practice and address not only physicians [e.g. general practitioners (GPs) and cardiologists] interested in CVD prevention, but also specialists from lipid clinics or metabolic units who are dealing with dyslipidaemias that are more difficult to classify and treat. [less ▲]

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See detailContinuous-flow production of alkyl nitrites
Monbaliu, Jean-Christophe ULg; Jorda, Jeremy; Chevalier, Bérengère et al

in Chimica Oggi = Chemistry Today (2011), 29

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See detailAnalytical validation of the Liaison Calcitonin_II-Gen (DiaSorin)
Cavalier, Etienne ULg; Carlisi, Ignazia ULg; Bekaert, Anne-Catherine ULg et al

in Clinical Chemistry & Laboratory Medicine (2011), 49(2), 271-275

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