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See detailNucleolar structure across evolution: the transition between bi- and tri-compartmentalized nucleoli lies within the class Reptilia.
Lamaye, Francoise; Galliot, Sonia; Alibardi, Lorenzo et al

in Journal of Structural Biology (2011), 174(2), 352-9

Two types of nucleolus can be distinguished among eukaryotic cells: a tri-compartmentalized nucleolus in amniotes and a bi-compartmentalized nucleolus in all the others. However, though the nucleolus ... [more ▼]

Two types of nucleolus can be distinguished among eukaryotic cells: a tri-compartmentalized nucleolus in amniotes and a bi-compartmentalized nucleolus in all the others. However, though the nucleolus' ultrastructure is well characterized in mammals and birds, it has been so far much less studied in reptiles. In this work, we examined the ultrastructural organization of the nucleolus in various tissues from different reptilian species (three turtles, three lizards, two crocodiles, and three snakes). Using cytochemical and immunocytological methods, we showed that in reptiles both types of nucleolus are present: a bi-compartmentalized nucleolus in turtles and a tri-compartmentalized nucleolus in the other species examined in this study. Furthermore, in a given species, the same type of nucleolus is present in all the tissues, however, the importance and the repartition of those nucleolar components could vary from one tissue to another. We also reveal that, contrary to the mammalian nucleolus, the reptilian fibrillar centers contain small clumps of condensed chromatin and that their surrounding dense fibrillar component is thicker. Finally, we also report that Cajal bodies are detected in reptiles. Altogether, we believe that these results have profound evolutionarily implications since they indicate that the point of transition between bipartite and tripartite nucleoli lies at the emergence of the amniotes within the class Reptilia. [less ▲]

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See detailTravailler moins pour travailler plus longtemps
Cremer, Helmuth; Dedonder, Philippe; Maldonado, Dario et al

in Annales d’Economie et de Statistique = Annals of Economics and Statistics (2011), 2(101/102), 257-270

Nous développons un modèle dans lequel les travailleurs peuvent avoir tendance à trop travailler quand ils sont jeunes, parce qu’ils ne peuvent ou ne veulent pas voir les conséquences que cela peut avoir ... [more ▼]

Nous développons un modèle dans lequel les travailleurs peuvent avoir tendance à trop travailler quand ils sont jeunes, parce qu’ils ne peuvent ou ne veulent pas voir les conséquences que cela peut avoir sur leur santé et sur leur capacité à travailler longtemps. Pour les obliger à mieux répartir leurs efforts sur leur cycle de vie, une taxe sur les revenus du travail en début de vie et une subvention de l’épargne sont souhaitables. Si la subvention de l’épargne n’est pas disponible, la taxe optimale arbitre entre quatre considérations différentes. Nous étudions également la taxe optimale quand les individus diffèrent en productivité. [less ▲]

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See detailDioxin2011 Highlights
Focant, Jean-François ULg

Report (2011)

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See detailPrincipaux modèles utilisés en régression logistique
Gillet, Adeline; Brostaux, Yves ULg; Palm, Rodolphe ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2011), 15(3), 425-433

Regression is a commonly used technique for describing the relationship between a response variable and one or more explanatory variables. When the response variable is a categorical variable, usual ... [more ▼]

Regression is a commonly used technique for describing the relationship between a response variable and one or more explanatory variables. When the response variable is a categorical variable, usual regression based on ordinary least squares should be replaced by logistic regression. Binary logistic regression should be used to perform a regression on a dichotomous response. Nominal polytomous logistic regression applies to a categorical response variable that has more than two levels with a natural ordering. And ordinal polytomous logistic regression is used when the response is a categorical variable that has more than two levels with a natural ordering. This note gives an overview of these logistic regression methods and describes three models commonly used when performing ordinal logistic regression. These models are illustrated by an example related to oak decline in the Walloon Region (Belgium). [less ▲]

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See detailCO2 reforming of methane: valorizing CO2 by means of Dielectric Barrier Discharge
Machrafi, Hatim ULg; Cavadias, Simeon; Amouroux, Jacques

in IOP Conference Series: Materials Science and Engineering (2011), 19(1), 012006

The impact of pollution on the environment is causing several problems that are to be reduced as much as possible. One important example is the production of CO2 that is emitted by many transport and ... [more ▼]

The impact of pollution on the environment is causing several problems that are to be reduced as much as possible. One important example is the production of CO2 that is emitted by many transport and industrial applications. An interesting solution is to view CO2 as a source instead of a product that can be stocked. The case considered in this work is the CO2 reformation of methane producing hydrogen and CO. It is an endothermic reaction, for which the activition barrier needs to be overcome. The method of Dielectric Barrier Discharge can do this efficiently. The process relies on the collision of electrons, which are accelerated under an electrical field that is created in the discharge area. This leads to the formation of reactive species, which facilitate the abovementioned reaction. The determination of the electron density is performed by PLASIMO. The study is subsequently continued using the Reaction Engineering module in COMSOL (with an incorporated kinetic mechanism) in order to model the discharge phase. Then COMSOL (continuity and Navier-Stokes equations) is used to model the flow in the post-discharge phase. The results showed that both a 2D and 3D model can be used to model the chemical-plasma process. These methods need strongly reduced kinetic mechanism, which in some cases can cause loss of precision. It is also observed that the present experimental set-up that is modeled needs to be improved. A suggestion is made. [less ▲]

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See detailInfluence du territoire sur le bâti existant en Wallonie
Teller, Jacques ULg

Conference given outside the academic context (2011)

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See detailMolecular recognition force spectroscopy
Willet, Nicolas ULg; Lamprecht, Constanze; Rankl, Christian et al

in Duwez, Anne-Sophie; Willet, Nicolas (Eds.) Molecular manipulation with atomic force microscopy (2011)

This chapter describes the state of the art in molecular recognition force spectroscopy performed by AFM. The different aspects of the topic are discussed, as the appropriate techniques for the ... [more ▼]

This chapter describes the state of the art in molecular recognition force spectroscopy performed by AFM. The different aspects of the topic are discussed, as the appropriate techniques for the functionalization of cantilever tips and for the preparation of (biological) samples. The principles of single-molecule force spectroscopy are then explained, together with exciting and recent examples on synthetic and biological samples. Finally, the main techniques to map molecular recognition interactions are reviewed and discussed in terms of performances. Novel and interesting applications illustrate the use of these imaging methods. [less ▲]

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See detailL’évaluation de la réflexivité dans des portfolios électroniques dans le cadre d’un cours de Soins Palliatifs en formation médicale de base
Giet, Didier ULg; MASSART, Valérie ULg; Deum, Mélanie ULg et al

Conference (2011)

Le cours de Médecine Palliative est organisé en avant-dernière année des études médicales de 2e cycle par deux enseignants, Médecin Généraliste et Médecin Hospitalier. Ce cours a été dispensé pendant 10 ... [more ▼]

Le cours de Médecine Palliative est organisé en avant-dernière année des études médicales de 2e cycle par deux enseignants, Médecin Généraliste et Médecin Hospitalier. Ce cours a été dispensé pendant 10 ans selon un format traditionnel ex cathedra. Il était dispensé par de nombreux intervenants pluridisciplinaires. Une évaluation des enseignements a montré que les étudiants jugeaient les interventions trop théoriques, sans lien avec leurs questions et préoccupations. En conséquence, c’est la discipline « Médecine Palliative et de Soins de Vie » qui ne suscitaient pas d’intérêt. De nouveaux objectifs et de nouvelles modalités pédagogiques ont été introduits en 2010-2011 à l’attention de 100 étudiants. L’objectif principal est le développement chez les étudiants d’une attitude réflexive face à la discipline « Médecine Palliative ». Les outils pédagogiques introduits dans le dispositif sont le portfolio électronique, une vignette clinique évolutive, l’accompagnement à distance de chaque étudiant par un tuteur, des cours en présentiel. La pratique réflexive de chaque étudiant est évaluée au terme du dispositif, conjointement par les 2 enseignants sur base de critères et d’indicateurs. Voici une illustration des critères utilisés : - Intensité des interactions dans le carnet d’apprentissage électronique (et aux cours) - Pertinence des interventions - Engagement dans la tâche - Capacité réflexive (pertinence de l’analyse et de la régulation de la situation décrite dans la vignette) - Qualité de l’auto-évaluation et identification des éléments déclencheurs de progrès - Degré d’apprentissage (Bilan d’atteinte des objectifs fixés par le cours et décrits) La communication orale présentera le dispositif d’évaluation, les critères et les indicateurs utilisés, les premiers résultats de l’évaluation des étudiants, les perspectives de régulation du dispositif d’évaluation. [less ▲]

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See detailA study of institutional environment and household food security at local level in Rwanda
Mathai, Jose A.; Musabanganji, Edouard ULg; Niwemahoro, Celine et al

in Rwanda Journal (2011), 22(Série B : Social Sciences), 96-128

The study looked into the current scenario of food security in Rwanda. After analysing the national level institutional and food security scenarios by using available secondary data, the researchers used ... [more ▼]

The study looked into the current scenario of food security in Rwanda. After analysing the national level institutional and food security scenarios by using available secondary data, the researchers used primary data that have been collected from a random sample of 200 households spreading over six sectors of the Huye district by using structured interview schedule, as well using a case study of a rice cooperative in Huye district. Focus group discussions with all stake holders concerned with food security at local level enriched the data that we collected by other means. The general conclusion that emerges from the study is that in order to attain the food security at local level in Rwanda lot more to be done. Among other things, strengthening existing local institutions like farmer cooperatives, improving agricultural production technology, diversifying household income sources for better access, and genuine integration of food security concerns in the district development plans. The researchers come out with certain policy recommendations that may make the local level food security more sustainable which includes, among others, the orientation of the households well into the new modes of agricultural production and planning of household income. The need for much more local level institutional support in many areas is highlighted. On the whole, the study addressed the concerns of food access among rural households in Rwanda, and also the much wanted institutional support being exposed. [less ▲]

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See detailElectron-deficient 1- and 2-aza-1,3-dienes: a comprehensive survey of their synthesis and reactivity
Monbaliu, Jean-Christophe ULg; Masschelein, Kurt; Stevens, Christian

in Chemical Society Reviews (2011), 40

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See detailInterface cerveau-ordinateur : une aide à la communication ?
Chatelle, Camille ULg; Lugo, Zulay; Noirhomme, Quentin ULg et al

in Schnakers, Caroline; Laureys, Steven (Eds.) Coma et états de conscience altérée (2011)

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See detailDirect nano-in-micropatterning of TiO2 thin layers and TiO2/Pt nanoelectrode arrays by deep X-ray lithography
Faustini, M.; Marmiroli, B.; Malfatti, L. et al

in Journal of Materials Chemistry (2011), 21

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See detailFamiliarité spatiale dans deux communes périurbaines belges
Dubois, Charline ULg; Schmitz, Serge ULg

in Cahiers de Géographie du Quebec (2011), 55(154), 51-65

Analysing spatial familiarity aims to measure how places included in the life-world and in the cognitive map are familiar. Based on the study of Gale, Golledge, Halperin & Couclelis (1990), this paper ... [more ▼]

Analysing spatial familiarity aims to measure how places included in the life-world and in the cognitive map are familiar. Based on the study of Gale, Golledge, Halperin & Couclelis (1990), this paper explores the spatial familiarity of the inhabitants of two municipalities at the fringe of Liege (Belgium): it questions the links between the cognitive dimensions (visual, nominal, localisation) and themselves and the behavioural dimension (passing). It seeks new relevant places for the population of these urban fringe as well as the favourable factors to a good familiarity of a place. Finally, it scrutinizes the influence of people's mobility – period of residence, commuting to work, modes of transport – on spatial familiarity. [less ▲]

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See detailMaintaining the communication and information tool of the Belgian anesthesiology community
BONHOMME, Vincent ULg

in Acta Anaesthesiologica Belgica (2011), 62(4), 173-174

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See detailGonadal pathology and tumor risk in relation to clinical characteristics in patients with 45,X/46,XY mosaicism
Cools, M.; Pleskacova, J.; Stoop, H. et al

in Journal of Clinical Endocrinology and Metabolism (2011), 96(7), 1171-1180

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See detailEnhanced Activity of Meprin-a, a Pro-Migratory and Pro-Angiogenic Protease, in Colorectal Cancer
Lottaz, Daniel; Maurer, Christoph A; Noël, Agnès ULg et al

in PLoS ONE (2011), 6(11), 26450

Meprin-α is a metalloprotease overexpressed in cancer cells, leading to the accumulation of this protease in a subset of colorectal tumors. The impact of increased meprin-α levels on tumor progression is ... [more ▼]

Meprin-α is a metalloprotease overexpressed in cancer cells, leading to the accumulation of this protease in a subset of colorectal tumors. The impact of increased meprin-α levels on tumor progression is not known. We investigated the effect of this protease on cell migration and angiogenesis in vitro and studied the expression of meprin-α mRNA, protein and proteolytic activity in primary tumors at progressive stages and in liver metastases of patients with colorectal cancer, as well as inhibitory activity towards meprin-α in sera of cancer patient as compared to healthy controls. We found that the hepatocyte growth factor (HGF)- induced migratory response of meprin-transfected epithelial cells was increased compared to wild-type cells in the presence of plasminogen, and that the angiogenic response in organ-cultured rat aortic explants was enhanced in the presence of exogenous human meprin-α. In patients, meprin-α mRNA was expressed in colonic adenomas, primary tumors UICC (International Union Against Cancer) stage I, II, III and IV, as well as in liver metastases. In contrast, the corresponding protein accumulated only in primary tumors and liver metastases, but not in adenomas. However, liver metastases lacked meprin-α activity despite increased expression of the corresponding protein, which correlated with inefficient zymogen activation. Sera from cancer patients exhibited reduced meprin-α inhibition compared to healthy controls. In conclusion, meprin-α activity is regulated differently in primary tumors and metastases, leading to high proteolytic activity in primary tumors and low activity in liver metastases. By virtue of its pro-migratory and pro-angiogenic activity, meprin-α may promote tumor progression in colorectal cancer. [less ▲]

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See detailInfections à herpèsvirus chez les ruminants et les éléphants
Thiry, Etienne ULg; Thiry, J.

in Bulletin de l'Académie Vétérinaire de France (2011), 164

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See detailInterpretations of Polar Bear (Ursus maritimus) Tracks by Inuit Hunters: Inter-rater Reliability and Inferences Concerning Accuracy
Wong, Pamela; Van Coeverden de Groot, Peter; Fekken, Cynthia et al

in Canadian Field-Naturalist (2011), 125(2), 140-153

due to their tracking experience in pursuing Polar Bears (Ursus maritimus), Inuit hunters could provide non-invasive estimates of Polar Bear characteristics from tracks, and Polar Bear monitoring programs ... [more ▼]

due to their tracking experience in pursuing Polar Bears (Ursus maritimus), Inuit hunters could provide non-invasive estimates of Polar Bear characteristics from tracks, and Polar Bear monitoring programs could benefit from Inuit input. We determined i) inter-rater reliability of estimates of the sex, age, and size of Polar Bears, and estimates of the age of tracks made by a group of nine Inuit hunters who interpreted 78 tracks; ii) we made preliminary comparisons of sex and size estimates with conventional (scientific) estimates; iii) we catalogued the Polar Bear hunting experience and track interpretation techniques of nine Inuit hunters; and iv) we explored relationships between hunting experience and the ability to interpret tracks. The group of Inuit hunters made reliable and consistent estimates of Polar Bear sex, age, and size, as well as estimates of age of track (after data from one participant was excluded). Although our comparisons are based on small samples, our findings suggest that Inuit hunters may be accurate in estimating the sex of Polar Bears (74.42% agreement with genetic determinations) and the size of Polar Bears from their tracks. our data indicate shared tracking techniques used by hunters may explain high agreement in making specific estimates, while individual hunting experience and particular methods used to interpret tracks may lead to inter-rater reliability and accuracy in interpreting tracks. [less ▲]

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