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See detailOptimal design of multi-subject blocked fMRI experiments.
Maus, Bärbel ULg; van Breukelen, Gerard J P; Goebel, Rainer et al

in NeuroImage (2011), 56(3), 1338-1352

The design of a multi-subject fMRI experiment needs specification of the number of subjects and scanning time per subject. For example, for a blocked design with conditions A or B, fixed block length and ... [more ▼]

The design of a multi-subject fMRI experiment needs specification of the number of subjects and scanning time per subject. For example, for a blocked design with conditions A or B, fixed block length and block order ABN, where N denotes a null block, the optimal number of cycles of ABN and the optimal number of subjects have to be determined. This paper presents a method to determine the optimal number of subjects and optimal number of cycles for a blocked design based on the A-optimality criterion and a linear cost function by which the number of cycles and the number of subjects are restricted. Estimation of individual stimulus effects and estimation of contrasts between stimulus effects are both considered. The mixed-effects model is applied and analytical results for the A-optimal number of subjects and A-optimal number of cycles are obtained under the assumption of uncorrelated errors. For correlated errors with a first-order autoregressive (AR1) error structure, numerical results are presented. Our results show how the optimal number of cycles and subjects depend on the within- to between-subject variance ratio. Our method is a new approach to determine the optimal scanning time and optimal number of subjects for a multi-subject fMRI experiment. In contrast to previous results based on power analyses, the optimal number of cycles and subjects can be described analytically and costs are considered. [less ▲]

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See detailNegations at Medinet Habu
Gillen, Todd Jonathan ULg

Conference (2011)

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See detailBrain natriuretic peptide in asymptomatic degenerative mitral regurgitation: determinants and impact on outcome.
Van de Heyning, C; Magne, Julien ULg; Mahjoub, H et al

Conference (2011)

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See detailIntroduction : "Nourrir les dieux ?"
Pirenne-Delforge, Vinciane ULg; Prescendi, Francesca

in Pirenne-Delforge, Vinciane; Prescendi, Francesca (Eds.) "Nourrir les dieux ?" Sacrifice et représentation du divin (2011)

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See detailA discrete competitive facility location model with variable attractiveness
Kucukaydin, Hande ULg; Aras, Necati; Altinel, I. Kuban

in Journal of the Operational Research Society (2011), 62(9), 1726-1741

We consider the discrete version of the competitive facility location problem in which new facilities have to be located by a new market entrant firm to compete against already existing facilities that ... [more ▼]

We consider the discrete version of the competitive facility location problem in which new facilities have to be located by a new market entrant firm to compete against already existing facilities that may belong to one or more competitors. The demand is assumed to be aggregated at certain points in the plane and the new facilities can be located at predetermined candidate sites. We employ Huff’s gravity-based rule in modelling the behaviour of the customers where the probability that customers at a demand point patronize a certain facility is proportional to the facility attractiveness and inversely proportional to the distance between the facility site and demand point. The objective of the firm is to determine the locations of the new facilities and their attractiveness levels so as to maximize the profit, which is calculated as the revenue from the customers less the fixed cost of opening the facilities and variable cost of setting their attractiveness levels. We formulate a mixed-integer nonlinear programming model for this problem and propose three methods for its solution: a Lagrangean heuristic, a branch-and-bound method with Lagrangean relaxation, and another branch-and-bound method with nonlinear programming relaxation. Computational results obtained on a set of randomly generated instances show that the last method outperforms the others in terms of accuracy and efficiency and can provide an optimal solution in a reasonable amount of time. [less ▲]

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See detailLack of efficacy of low-dose spironolactone as adjunct treatment to conventional congestive heart failure treatment in dogs
Schuller, S.; Van Israël, N.; Vanbelle, S. et al

in Journal of Veterinary Pharmacology & Therapeutics (2011)

Aldosterone plays an important role in the pathophysiology of heart failure. Aldosterone receptor blockade has been shown to reduce morbidity and mortality in human patients with advanced congestive left ... [more ▼]

Aldosterone plays an important role in the pathophysiology of heart failure. Aldosterone receptor blockade has been shown to reduce morbidity and mortality in human patients with advanced congestive left ventricular heart failure. This study was designed to assess the efficacy and tolerance of long-term low-dose spironolactone when added to conventional heart failure treatment in dogs with advanced heart failure. Eighteen client-owned dogs with advanced congestive heart failure due to either degenerative valve disease (n=11) or dilated cardiomyopathy (n=7) were included in this prospective, placebo-controlled, double-blinded, randomized clinical study. After initial stabilization including furosemide, angiotensin-converting enzyme inhibitors, pimobendan and digoxin, spironolactone at a median dose of 0.52 mg/kg (range 0.49-0.8 mg/kg) once daily (n=9) or placebo (n=9) was added to the treatment, and the dogs were reassessed 3 and 6 months later. Clinical scoring, echocardiography, electrocardiogram, systolic blood pressure measurement, thoracic radiography, sodium, potassium, urea, creatinine, alanine aminotransferase, aldosterone and aminoterminal atrial natriuretic propeptide were assessed at baseline, 3 and 6 months. Survival times were not significantly different between the two treatment groups. Spironolactone was well tolerated when combined with conventional heart failure treatment. [less ▲]

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See detailProspects for harmonized biodiversity assessments using national forest inventory data
McRoberts, Ronald E.; Chirici, Gherardo; Winter, Susanne et al

in Chirici, Gherardo; Winter, Susanne; McRoberts, Ronald E. (Eds.) National Forest Inventories - contributions to Forest Biodiversity Assessments (2011)

After selection of the 13 biodiversity variables (Sect. 2.3) based on their importance and feasibility for assessment by NFIs, responses were solicited from participating countries regarding the degree to ... [more ▼]

After selection of the 13 biodiversity variables (Sect. 2.3) based on their importance and feasibility for assessment by NFIs, responses were solicited from participating countries regarding the degree to which the variables are now assessed. Two conclusions were evident: (1) most countries currently assess most of the variables, but (2) consensus is lacking on assessment methods and necessary field crew expertise, suggesting that harmonization would require emphasis on field operations. For each of the seven essential features into which the 13 variables were grouped, more detailed assessments were conducted. For forest categories, the conclusion was that the only major difference in classification systems used by European NFIs was whether potential or actual vegetation was used to define classes. Thus, the prospects for harmonization of forest categories are considered excellent. For forest structure, the prospects depend on the variable. For tree species, the prospects are excellent because the variable is assessed in the same manner by all NFIs. For dbh and height, considerable variability in measurementthresholds were found, but otherwise the harmonization prospects are good. For social position, definitions of classes varied, but harmonized estimates of proportions for dominant, intermediate, and suppressed classes are considered possible. Prospects for harmonized estimates of layers are consideraly poorer because of different definitions, thresholds and the uncertainty associated with visual assessment methods. Harmonized estimation of forest age is impeded by the increasing proportion of uneven-aged stands for which age is often not assessed, different definitions, and different assessment methods. However, agreement on dominant age as a reference definition would greatly increase the prospects. Deadwood is becoming an increasingly popular indicator of sustainable forest management. Unfortunately, considerable variability was found in deadwood definitions, components (e.g., stumps, limbs), sampling methods, and measurement thresholds. Thus, harmonized deadwood estimation will require development of bridges. Harmonization of regeneration estimates faces challenges due to differences in assessment approaches such as presence/absence versus coverage and all species versus dominant species. Harmonized estimation may be restricte to change in regeneration success. Harmonized estimation for ground vegetation also faces serious challenges due to differences in the components assessed (e.g., small trees, shrubs, herbs, bryophytes, lichens), difference in height thresholds, and differences in categories for which ground vegetation is reported. Forest naturalness integrates many of the other essential feature. However, many countries do not assess naturalness, and among those that do, assessment variables, methods, and reporting classes vary considerably. For harmonized assessment using NFI variables, the hemeroby approach, which emphasizes indications of human influence, is extremely sensitive to plot size. Harmonization using the ecosystem processes approach requires a common dbh threshold and similar plot sizes. The overall conclusion is that harmonization will be considerably easier for some essential features than for others. The factors leading to difficulties often are related to different definitions, different reporting classes, different measurement thresholds, and different features of sampling protocols such as plot sizes and configurations. Nevertheless, construction of reference definitions and bridges greatly facilitate harmonization for all essential features as is illustrated in Chap. 5. [less ▲]

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See detailInferring internal anatomy from the trilobite exoskeleton: the relationship between frontal auxiliary impressions and the digestive system
Lerosey-Aubril, Rudy; Hegna, Thomas; Olive, Sébastien ULg

in Lethaia (2011), 44(2),

The digestive system of trilobites is rarely preserved. As a result, many aspects of its organization remain unknown. Fortunately, the exoskeleton sometimes preserves evidence of soft-tissue attachment ... [more ▼]

The digestive system of trilobites is rarely preserved. As a result, many aspects of its organization remain unknown. Fortunately, the exoskeleton sometimes preserves evidence of soft-tissue attachment sites that can be used to infer internal anatomy. Among them are the frontal auxiliary impressions (FAIs), probable soft-tissue insertion sites located on the fronto-median glabellar lobe of some trilobites. FAIs are herein described in the Carboniferous trilobite Phillipsia belgica Osmo´ lska 1970 – representing the only known example of such structures in the Proetida and their youngest occurrence. A taphonomic scenario is proposed to explain their variable preservation. Although particularly common in the Phacopina, FAIs or FAI-like structures are also found in several orders that differ greatly. Comparisons with modern analogues suggest that FAIs might represent attachment sites for extrinsic muscles associated with a differentiated crop within the foregut. A review of purported remains of the trilobite digestive system indicates that it usually consisted of a tube-like tract flanked by a variable number of metamerically paired diverticulae. Its anterior portion is not particularly individualized, except in a few specimens that might hint at the presence of a crop. This differentiation of a crop might have constituted a secondarily evolution of the foregut in trilobites, occurring independently in different clades. Accompanied by a strengthening of associated extrinsic muscles, this modification of the foregut might explain the presence of more conspicuous muscle insertion sites on the glabella. Study of FAIs might therefore provide new data on the anatomy of the foregut in trilobites and evidence of diverse feeding habits. [less ▲]

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See detailConvergence of Logic of Cellular Regulation in Different Premalignant Cells by an Information Theoretic Approach
Kravchenko-Balasha, N.; Remacle, Françoise ULg; Gross, A. et al

in BMC Systems Biology (2011), 5

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See detailConstraining statistical-model parameters using fusion and spallation reactions
Mancusi, D.; Charity, R. J.; Cugnon, Joseph ULg

in European Physics Journal: Web of conferences (2011)

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See detailNote de lecture de: Frédéric Lordon, Capitalisme, désir et servitude
Cavazzini, Andrea ULg

in Les Carnets des Cahiers Philosophiques (2011)

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See detailInfluence of veneer thickness on residual stress profile in veneering ceramic: Measurement by hole-drilling.
MAINJOT, Amélie ULg; Schajer, G. S.; Vanheusden, Alain ULg et al

in Dental Materials (2011)

OBJECTIVES: The veneering process of frameworks induces residual stresses and can initiate cracks when combined with functional stresses. The stress distribution within the veneering ceramic as a function ... [more ▼]

OBJECTIVES: The veneering process of frameworks induces residual stresses and can initiate cracks when combined with functional stresses. The stress distribution within the veneering ceramic as a function of depth is a key factor influencing failure by chipping. This is a well-known problem with Yttria-tetragonal-zirconia-polycrystal based fixed partial dentures. The objective of this study is to investigate the influence of veneer thickness on the stress profile in zirconia- and metal-based structures. METHODS: The hole-drilling method, often used for engineering measurements, was adapted for use with veneering ceramic. The stress profile was measured in bilayered disc samples of 20mm diameter, with a 1mm thick zirconia or metal framework. Different veneering ceramic thicknesses were performed: 1mm, 1.5mm, 2mm, 2.5mm and 3mm. RESULTS: All samples exhibited the same type of stress vs. depth profile, starting with compressive at the ceramic surface, decreasing with depth up to 0.5-1.0mm from the surface, and then becoming compressive again near the framework, except for the 1.5mm-veneered zirconia samples which exhibited interior tensile stresses. Stresses in the surface of metal samples were not influenced by veneer thickness. Variation of interior stresses at 1.2mm from the surface in function of veneer thickness was inverted for metal and zirconia samples. SIGNIFICANCE: Veneer thickness influences in an opposite way the residual stress profile in metal- and in zirconia-based structures. A three-step approach and the hypothesis of the crystalline transformation are discussed to explain the less favorable residual stress development in zirconia samples. [less ▲]

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See detailUnderstanding Crystallization of Anatase into Binary SiO2/TiO2 Sol-Gel Optical Thin Films: An in Situ Thermal Ellipsometry Analysis
Louis, B.; Krins, Natacha ULg; Faustini, M. et al

in Journal of Physical Chemistry C: Nanomaterials, Interfaces, and Hard Matter (2011), 115

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See detailHydrogeological study of Somes-Szamos transboundary alluvial aquifer
Drobot, Radu; Szucs, Peter; Brouyère, Serge ULg et al

in Ganoulis, Jacques; Aureli, Alice; Fried, Jean (Eds.) Transboundary Water Resources Management: A Multidisciplinary Approach (2011)

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See detailTrabectedine (ET-743/Yondelis) dans le traitement des sarcomes des tissus mous et du cancer de l'ovaire.
GENNIGENS, Christine ULg; Jerusalem, Guy ULg

in Revue Médicale de Liège (2011), 66(7-8), 452-5

Soft tissue sarcomas account for 1% of all malignant tumours. Until a few years ago, doxorubicine and ifosfamide were the only active chemotherapy drugs in the metastatic setting. Recently, a new drug has ... [more ▼]

Soft tissue sarcomas account for 1% of all malignant tumours. Until a few years ago, doxorubicine and ifosfamide were the only active chemotherapy drugs in the metastatic setting. Recently, a new drug has proven its efficacy after failure of standard treatments: the trabectedin; its activity is based on interference with ADN repair mechanisms. Trabectedin has just been also validated and reimbursed in patients with ovarian cancer, in partially sensitive recurrence. In this paper, we will review the mechanism of action and the clinical results of trabectedin. [less ▲]

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See detailRobust maximum weighted independent-set problems on interval graphs
Talla Nobibon, Fabrice ULg; Leus, Roel

Report (2011)

We study the maximum weighted independent-set problem on interval graphs with uncertainty on the vertex weights. We use the absolute robustness criterion and the min-max regret criterion to evaluate ... [more ▼]

We study the maximum weighted independent-set problem on interval graphs with uncertainty on the vertex weights. We use the absolute robustness criterion and the min-max regret criterion to evaluate solutions. For a discrete scenario set, we nd that the problem is NP-hard for each of the robustness criteria; we also provide pseudo-polynomial time algorithms when there is a constant number of scenarios and show that the problem is strongly NP-hard when the set of scenarios is unbounded. When the scenario set is a Cartesian product, we prove that the problem is equivalent to a maximum weighted independent-set problem on the same interval graph but without uncertainty for the rst objective function and that the scenario set can be reduced for the second objective function. [less ▲]

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